Trifunctional purine biosynthetic protein adenosine-3

A trifunctional purine biosynthetic protein adenosine-3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P22102]

Synonyms

Research

Bioassay Publications (18)

Timeframe	Studies on this Protein(%)	All Drugs %
pre-1990	1 (5.56)	18.7374
1990's	2 (11.11)	18.2507
2000's	5 (27.78)	29.6817
2010's	9 (50.00)	24.3611
2020's	1 (5.56)	2.80

Compounds (4)

Drugs with Inhibition Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
methotrexate	Homo sapiens (human)	IC50	10.0050	2	2
5,11-methenyltetrahydrohomofolate	Homo sapiens (human)	IC50	3.0000	1	1
pemetrexed	Homo sapiens (human)	IC50	5.0285	6	6
pemetrexed	Homo sapiens (human)	Ki	0.6112	4	4
lometrexol	Homo sapiens (human)	IC50	2.8508	5	5
lometrexol	Homo sapiens (human)	Ki	0.0580	6	7

Enables

This protein enables 5 target(s):

Target	Category	Definition
phosphoribosylamine-glycine ligase activity	molecular function	Catalysis of the reaction: 5-phospho-D-ribosylamine + ATP + glycine = N(1)-(5-phospho-D-ribosyl)glycinamide + ADP + 2 H+ + phosphate. [EC:6.3.4.13, RHEA:17453]
phosphoribosylformylglycinamidine cyclo-ligase activity	molecular function	Catalysis of the reaction: 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine + ATP = 5-amino-1-(5-phospho-D-ribosyl)imidazole + ADP + 2 H+ + phosphate. [EC:6.3.3.1, RHEA:23032]
phosphoribosylglycinamide formyltransferase activity	molecular function	Catalysis of the reaction: 10-formyltetrahydrofolate + N1-(5-phospho-D-ribosyl)glycinamide = tetrahydrofolate + N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide. [EC:2.1.2.2]
ATP binding	molecular function	Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. [ISBN:0198506732]
metal ion binding	molecular function	Binding to a metal ion. [GOC:ai]

Located In

This protein is located in 2 target(s):

Target	Category	Definition
cytosol	cellular component	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]
extracellular exosome	cellular component	A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894]

Active In

This protein is active in 1 target(s):

Target	Category	Definition
cytosol	cellular component	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]

Involved In

This protein is involved in 14 target(s):

Target	Category	Definition
brainstem development	biological process	The progression of the brainstem from its formation to the mature structure. The brainstem is the part of the brain that connects the brain with the spinal cord. [GOC:dph]
GMP biosynthetic process	biological process	The chemical reactions and pathways resulting in the formation of GMP, guanosine monophosphate. [ISBN:0198506732]
'de novo' IMP biosynthetic process	biological process	The chemical reactions and pathways resulting in the formation of IMP, inosine monophosphate, by the stepwise assembly of a purine ring on ribose 5-phosphate. [GOC:mah, ISBN:0716720094]
glycine metabolic process	biological process	The chemical reactions and pathways involving glycine, aminoethanoic acid. [GOC:go_curators]
purine ribonucleoside monophosphate biosynthetic process	biological process	The chemical reactions and pathways resulting in the formation of purine ribonucleoside monophosphate, a compound consisting of a purine base linked to a ribose sugar esterified with phosphate on the sugar. [GOC:go_curators, ISBN:0198506732]
response to organic substance	biological process	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic substance stimulus. [GOC:sm, PMID:23356676]
response to inorganic substance	biological process	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an inorganic substance stimulus. [GOC:sm]
cerebellum development	biological process	The process whose specific outcome is the progression of the cerebellum over time, from its formation to the mature structure. The cerebellum is the portion of the brain in the back of the head between the cerebrum and the pons. In mice, the cerebellum controls balance for walking and standing, modulates the force and range of movement and is involved in the learning of motor skills. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
cerebral cortex development	biological process	The progression of the cerebral cortex over time from its initial formation until its mature state. The cerebral cortex is the outer layered region of the telencephalon. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]
'de novo' AMP biosynthetic process	biological process	The chemical reactions and pathways resulting in the formation of adenosine monophosphate (AMP) from inosine 5'-monophosphate (IMP). [GOC:ecd, PMID:10888601]
tetrahydrofolate biosynthetic process	biological process	The chemical reactions and pathways resulting in the formation of tetrahydrofolate, 5,6,7,8-tetrahydrofolic acid, a folate derivative bearing additional hydrogens on the pterin group. [ISBN:0198506732]
'de novo' XMP biosynthetic process	biological process	The chemical reactions and pathways resulting in the formation of XMP, xanthosine monophosphate, from simpler precursors. [GOC:yaf, MetaCyc:IMP-DEHYDROG-RXN, PMID:27590927]
purine nucleotide biosynthetic process	biological process	The chemical reactions and pathways resulting in the formation of a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar. [GOC:go_curators, ISBN:0198506732]
adenine biosynthetic process	biological process	The chemical reactions and pathways resulting in the formation of adenine, 6-aminopurine, one of the five main bases found in nucleic acids and a component of numerous important derivatives of its corresponding ribonucleoside, adenosine. [GOC:go_curators]

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