Proteins > Trifunctional purine biosynthetic protein adenosine-3
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Trifunctional purine biosynthetic protein adenosine-3
A trifunctional purine biosynthetic protein adenosine-3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P22102]
Synonyms
Research
Bioassay Publications (18)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 1 (5.56) | 18.7374 |
| 1990's | 2 (11.11) | 18.2507 |
| 2000's | 5 (27.78) | 29.6817 |
| 2010's | 9 (50.00) | 24.3611 |
| 2020's | 1 (5.56) | 2.80 |
Compounds (4)
Drugs with Inhibition Measurements
Novel 6-substituted benzoyl and non-benzoyl straight chain pyrrolo[2,3-d]pyrimidines as potential antitumor agents with multitargeted inhibition of TS, GARFTase and AICARFTase.European journal of medicinal chemistry, , Oct-20, Volume: 139, 2017
Synthesis and biological evaluation of 8-deazahomofolic acid and its tetrahydro derivative.Journal of medicinal chemistry, , Volume: 31, Issue:1, 1988
FDA-approved pyrimidine-fused bicyclic heterocycles for cancer therapy: Synthesis and clinical application.European journal of medicinal chemistry, , Mar-15, Volume: 214, 2021
Fluorine-Substituted Pyrrolo[2,3- d]Pyrimidine Analogues with Tumor Targeting via Cellular Uptake by Folate Receptor α and the Proton-Coupled Folate Transporter and Inhibition of de Novo Purine Nucleotide Biosynthesis.Journal of medicinal chemistry, , 05-10, Volume: 61, Issue:9, 2018
Novel 6-substituted benzoyl and non-benzoyl straight chain pyrrolo[2,3-d]pyrimidines as potential antitumor agents with multitargeted inhibition of TS, GARFTase and AICARFTase.European journal of medicinal chemistry, , Oct-20, Volume: 139, 2017
Tumor Targeting with Novel 6-Substituted Pyrrolo [2,3-d] Pyrimidine Antifolates with Heteroatom Bridge Substitutions via Cellular Uptake by Folate Receptor α and the Proton-Coupled Folate Transporter and Inhibition of de Novo Purine Nucleotide BiosynthesiJournal of medicinal chemistry, , 09-08, Volume: 59, Issue:17, 2016
Novel 5-substituted pyrrolo[2,3-d]pyrimidines as dual inhibitors of glycinamide ribonucleotide formyltransferase and 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase and as potential antitumor agents.Journal of medicinal chemistry, , Feb-12, Volume: 58, Issue:3, 2015
6-Substituted Pyrrolo[2,3-d]pyrimidine Thienoyl Regioisomers as Targeted Antifolates for Folate Receptor α and the Proton-Coupled Folate Transporter in Human Tumors.Journal of medicinal chemistry, , Sep-10, Volume: 58, Issue:17, 2015
Novel approaches for targeting thymidylate synthase to overcome the resistance and toxicity of anticancer drugs.Journal of medicinal chemistry, , Sep-23, Volume: 53, Issue:18, 2010
Synthesis and antitumor activity of a novel series of 6-substituted pyrrolo[2,3-d]pyrimidine thienoyl antifolate inhibitors of purine biosynthesis with selectivity for high affinity folate receptors and the proton-coupled folate transporter over the reducJournal of medicinal chemistry, , Feb-11, Volume: 53, Issue:3, 2010
Synthesis and biological activity of a novel series of 6-substituted thieno[2,3-d]pyrimidine antifolate inhibitors of purine biosynthesis with selectivity for high affinity folate receptors over the reduced folate carrier and proton-coupled folate transpoJournal of medicinal chemistry, , May-14, Volume: 52, Issue:9, 2009
Synthesis and discovery of high affinity folate receptor-specific glycinamide ribonucleotide formyltransferase inhibitors with antitumor activity.Journal of medicinal chemistry, , Aug-28, Volume: 51, Issue:16, 2008
Design, synthesis and biological evaluation of 6-substituted pyrrolo[2,3-d]pyrimidines as dual inhibitors of TS and AICARFTase and as potential antitumor agents.European journal of medicinal chemistry, , Jun-10, Volume: 115, 2016
Synthesis and biological activity of 6-substituted pyrrolo[2,3-d]pyrimidine thienoyl regioisomers as inhibitors of de novo purine biosynthesis with selectivity for cellular uptake by high affinity folate receptors and the proton-coupled folate transporterJournal of medicinal chemistry, , Feb-23, Volume: 55, Issue:4, 2012
Synthesis and antitumor activity of a novel series of 6-substituted pyrrolo[2,3-d]pyrimidine thienoyl antifolate inhibitors of purine biosynthesis with selectivity for high affinity folate receptors and the proton-coupled folate transporter over the reducJournal of medicinal chemistry, , Feb-11, Volume: 53, Issue:3, 2010
Synthesis and biological activity of a novel series of 6-substituted thieno[2,3-d]pyrimidine antifolate inhibitors of purine biosynthesis with selectivity for high affinity folate receptors over the reduced folate carrier and proton-coupled folate transpoJournal of medicinal chemistry, , May-14, Volume: 52, Issue:9, 2009
Asymmetric synthesis of inhibitors of glycinamide ribonucleotide transformylase.Journal of medicinal chemistry, , Sep-11, Volume: 51, Issue:17, 2008
Synthesis and discovery of high affinity folate receptor-specific glycinamide ribonucleotide formyltransferase inhibitors with antitumor activity.Journal of medicinal chemistry, , Aug-28, Volume: 51, Issue:16, 2008
Structure-based design, synthesis, evaluation, and crystal structures of transition state analogue inhibitors of inosine monophosphate cyclohydrolase.The Journal of biological chemistry, , Apr-27, Volume: 282, Issue:17, 2007
Discovery of a potent, nonpolyglutamatable inhibitor of glycinamide ribonucleotide transformylase.Journal of medicinal chemistry, , May-18, Volume: 49, Issue:10, 2006
Thienyl and thiazolyl acyclic analogues of 5-deazatetrahydrofolic acid.Journal of medicinal chemistry, , Jun-24, Volume: 37, Issue:13, 1994
Enables
This protein enables 5 target(s):
| Target | Category | Definition |
|---|
| phosphoribosylamine-glycine ligase activity | molecular function | Catalysis of the reaction: 5-phospho-D-ribosylamine + ATP + glycine = N(1)-(5-phospho-D-ribosyl)glycinamide + ADP + 2 H+ + phosphate. [EC:6.3.4.13, RHEA:17453] |
| phosphoribosylformylglycinamidine cyclo-ligase activity | molecular function | Catalysis of the reaction: 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine + ATP = 5-amino-1-(5-phospho-D-ribosyl)imidazole + ADP + 2 H+ + phosphate. [EC:6.3.3.1, RHEA:23032] |
| phosphoribosylglycinamide formyltransferase activity | molecular function | Catalysis of the reaction: 10-formyltetrahydrofolate + N1-(5-phospho-D-ribosyl)glycinamide = tetrahydrofolate + N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide. [EC:2.1.2.2] |
| ATP binding | molecular function | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. [ISBN:0198506732] |
| metal ion binding | molecular function | Binding to a metal ion. [GOC:ai] |
Located In
This protein is located in 2 target(s):
| Target | Category | Definition |
|---|
| cytosol | cellular component | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl] |
| extracellular exosome | cellular component | A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894] |
Active In
This protein is active in 1 target(s):
| Target | Category | Definition |
|---|
| cytosol | cellular component | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl] |
Involved In
This protein is involved in 14 target(s):
| Target | Category | Definition |
|---|
| brainstem development | biological process | The progression of the brainstem from its formation to the mature structure. The brainstem is the part of the brain that connects the brain with the spinal cord. [GOC:dph] |
| GMP biosynthetic process | biological process | The chemical reactions and pathways resulting in the formation of GMP, guanosine monophosphate. [ISBN:0198506732] |
| 'de novo' IMP biosynthetic process | biological process | The chemical reactions and pathways resulting in the formation of IMP, inosine monophosphate, by the stepwise assembly of a purine ring on ribose 5-phosphate. [GOC:mah, ISBN:0716720094] |
| glycine metabolic process | biological process | The chemical reactions and pathways involving glycine, aminoethanoic acid. [GOC:go_curators] |
| purine ribonucleoside monophosphate biosynthetic process | biological process | The chemical reactions and pathways resulting in the formation of purine ribonucleoside monophosphate, a compound consisting of a purine base linked to a ribose sugar esterified with phosphate on the sugar. [GOC:go_curators, ISBN:0198506732] |
| response to organic substance | biological process | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic substance stimulus. [GOC:sm, PMID:23356676] |
| response to inorganic substance | biological process | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an inorganic substance stimulus. [GOC:sm] |
| cerebellum development | biological process | The process whose specific outcome is the progression of the cerebellum over time, from its formation to the mature structure. The cerebellum is the portion of the brain in the back of the head between the cerebrum and the pons. In mice, the cerebellum controls balance for walking and standing, modulates the force and range of movement and is involved in the learning of motor skills. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] |
| cerebral cortex development | biological process | The progression of the cerebral cortex over time from its initial formation until its mature state. The cerebral cortex is the outer layered region of the telencephalon. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] |
| 'de novo' AMP biosynthetic process | biological process | The chemical reactions and pathways resulting in the formation of adenosine monophosphate (AMP) from inosine 5'-monophosphate (IMP). [GOC:ecd, PMID:10888601] |
| tetrahydrofolate biosynthetic process | biological process | The chemical reactions and pathways resulting in the formation of tetrahydrofolate, 5,6,7,8-tetrahydrofolic acid, a folate derivative bearing additional hydrogens on the pterin group. [ISBN:0198506732] |
| 'de novo' XMP biosynthetic process | biological process | The chemical reactions and pathways resulting in the formation of XMP, xanthosine monophosphate, from simpler precursors. [GOC:yaf, MetaCyc:IMP-DEHYDROG-RXN, PMID:27590927] |
| purine nucleotide biosynthetic process | biological process | The chemical reactions and pathways resulting in the formation of a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar. [GOC:go_curators, ISBN:0198506732] |
| adenine biosynthetic process | biological process | The chemical reactions and pathways resulting in the formation of adenine, 6-aminopurine, one of the five main bases found in nucleic acids and a component of numerous important derivatives of its corresponding ribonucleoside, adenosine. [GOC:go_curators] |