Compounds > mansonone f
Page last updated: 2024-12-07

mansonone f

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

Mansonone F is a natural product isolated from the bark of *Mansonia altissima* tree, a plant native to Africa. It exhibits a range of biological activities, including anti-inflammatory, antioxidant, and cytotoxic properties. Its unique structure and potential therapeutic applications have made it a subject of ongoing research. Studies are exploring its synthesis, mechanism of action, and potential applications in various diseases. Mansonone F is a promising candidate for drug development due to its potential benefits in treating inflammatory diseases, oxidative stress, and cancer.'

mansonone F: a potent anti-bacterial sesquiterpenoid; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID94304
CHEMBL ID197655
SCHEMBL ID3397051
MeSH IDM0480382

Synonyms (24)

Synonym
nsc113136
5090-88-0
naphtho[1,8-dione, 3,6,9-trimethyl-
nsc-113136
mansonone f
NCI60_000295
inchi=1/c15h12o3/c1-7-4-5-10-8(2)6-18-15-9(3)13(16)14(17)11(7)12(10)15/h4-6h,1-3h3
wsrlwspfioayst-uhfffaoysa-
CHEMBL197655
SCHEMBL3397051
bzi06h42qb ,
unii-bzi06h42qb
naphtho(1,8-bc)pyran-7,8-dione, 3,6,9-trimethyl-
nsc 113136
3,6,9-trimethylnaphtho(1,8-bc)pyran-7,8-dione
3,6,9-trimethylbenzo[de]chromene-7,8-dione #
naphtho[1,8-bc]pyran-7,8-dione, 3,6,9-trimethyl-
WSRLWSPFIOAYST-UHFFFAOYSA-N
DTXSID20198933
naphtho(1,8-bc)pyran-7,8-dione, 3,6,9-trimethyl- (8ci)(9ci)
3,6,9-trimethylbenzo[de]chromene-7,8-dione
4,8,12-trimethyl-2-oxatricyclo[7.3.1.05,13]trideca-1(12),3,5(13),6,8-pentaene-10,11-dione
3,6,9-trimethylnaphtho[1,8-bc]pyran-7,8-dione
AKOS040747135
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (21)

Assay IDTitleYearJournalArticle
AID258614Antibacterial activity against Micrococcus luteus ATCC 102402006Bioorganic & medicinal chemistry letters, Jan-01, Volume: 16, Issue:1
The structure-activity relationships of mansonone F, a potent anti-MRSA sesquiterpenoid quinone: SAR studies on the C6 and C9 analogs.
AID611122Antitumor against human GLC82 cells assessed as cell survival after 48 hrs by MTT assay2011European journal of medicinal chemistry, Aug, Volume: 46, Issue:8
Synthesis and evaluation of mansonone F derivatives as topoisomerase inhibitors.
AID258613Antibacterial activity against Staphylococcus aureus ATCC 292132006Bioorganic & medicinal chemistry letters, Jan-01, Volume: 16, Issue:1
The structure-activity relationships of mansonone F, a potent anti-MRSA sesquiterpenoid quinone: SAR studies on the C6 and C9 analogs.
AID258604Antibacterial activity against methicillin-resistant Staphylococcus aureus2006Bioorganic & medicinal chemistry letters, Jan-01, Volume: 16, Issue:1
The structure-activity relationships of mansonone F, a potent anti-MRSA sesquiterpenoid quinone: SAR studies on the C6 and C9 analogs.
AID258609Antibacterial activity against Staphylococcus epidermidis ATCC 122282006Bioorganic & medicinal chemistry letters, Jan-01, Volume: 16, Issue:1
The structure-activity relationships of mansonone F, a potent anti-MRSA sesquiterpenoid quinone: SAR studies on the C6 and C9 analogs.
AID258615Antibacterial activity against Staphylococcus aureus2006Bioorganic & medicinal chemistry letters, Jan-01, Volume: 16, Issue:1
The structure-activity relationships of mansonone F, a potent anti-MRSA sesquiterpenoid quinone: SAR studies on the C6 and C9 analogs.
AID258612Antibacterial activity against Micrococcus luteus ATCC 93412006Bioorganic & medicinal chemistry letters, Jan-01, Volume: 16, Issue:1
The structure-activity relationships of mansonone F, a potent anti-MRSA sesquiterpenoid quinone: SAR studies on the C6 and C9 analogs.
AID386973Oxidation of dihydrolipoamide assessed as oxygen consumption at 50 uM2008European journal of medicinal chemistry, Oct, Volume: 43, Issue:10
Studies of trypanocidal (inhibitory) power of naphthoquinones: evaluation of quantum chemical molecular descriptors for structure-activity relationships.
AID258610Antibacterial activity against Klebsiella pneumoniae ATCC 100312006Bioorganic & medicinal chemistry letters, Jan-01, Volume: 16, Issue:1
The structure-activity relationships of mansonone F, a potent anti-MRSA sesquiterpenoid quinone: SAR studies on the C6 and C9 analogs.
AID386975Antitrypanosomal activity against Crithidia fasciculata2008European journal of medicinal chemistry, Oct, Volume: 43, Issue:10
Studies of trypanocidal (inhibitory) power of naphthoquinones: evaluation of quantum chemical molecular descriptors for structure-activity relationships.
AID258611Antibacterial activity against Staphylococcus aureus2006Bioorganic & medicinal chemistry letters, Jan-01, Volume: 16, Issue:1
The structure-activity relationships of mansonone F, a potent anti-MRSA sesquiterpenoid quinone: SAR studies on the C6 and C9 analogs.
AID611121Antitumor against human CNE2 cells assessed as cell survival after 48 hrs by MTT assay2011European journal of medicinal chemistry, Aug, Volume: 46, Issue:8
Synthesis and evaluation of mansonone F derivatives as topoisomerase inhibitors.
AID258617Antibacterial activity against Staphylococcus aureus2006Bioorganic & medicinal chemistry letters, Jan-01, Volume: 16, Issue:1
The structure-activity relationships of mansonone F, a potent anti-MRSA sesquiterpenoid quinone: SAR studies on the C6 and C9 analogs.
AID386974Antitrypanosomal activity against Leptomonas seymouri2008European journal of medicinal chemistry, Oct, Volume: 43, Issue:10
Studies of trypanocidal (inhibitory) power of naphthoquinones: evaluation of quantum chemical molecular descriptors for structure-activity relationships.
AID258607Antibacterial activity against Staphylococcus aureus ATCC 259232006Bioorganic & medicinal chemistry letters, Jan-01, Volume: 16, Issue:1
The structure-activity relationships of mansonone F, a potent anti-MRSA sesquiterpenoid quinone: SAR studies on the C6 and C9 analogs.
AID386972Oxidation of dithiothreitol assessed as oxygen consumption at 50 uM2008European journal of medicinal chemistry, Oct, Volume: 43, Issue:10
Studies of trypanocidal (inhibitory) power of naphthoquinones: evaluation of quantum chemical molecular descriptors for structure-activity relationships.
AID258616Antibacterial activity against Staphylococcus aureus2006Bioorganic & medicinal chemistry letters, Jan-01, Volume: 16, Issue:1
The structure-activity relationships of mansonone F, a potent anti-MRSA sesquiterpenoid quinone: SAR studies on the C6 and C9 analogs.
AID611200Inhibition of human topoisomerase 1-mediated relaxation of supercoiled pBR322 DNA at 250 uM after 30 mins by agarose gel electrophoresis2011European journal of medicinal chemistry, Aug, Volume: 46, Issue:8
Synthesis and evaluation of mansonone F derivatives as topoisomerase inhibitors.
AID258606Antibacterial activity against Bacillus cereus ATCC 273482006Bioorganic & medicinal chemistry letters, Jan-01, Volume: 16, Issue:1
The structure-activity relationships of mansonone F, a potent anti-MRSA sesquiterpenoid quinone: SAR studies on the C6 and C9 analogs.
AID258608Antibacterial activity against Staphylococcus aureus ATCC 6538P2006Bioorganic & medicinal chemistry letters, Jan-01, Volume: 16, Issue:1
The structure-activity relationships of mansonone F, a potent anti-MRSA sesquiterpenoid quinone: SAR studies on the C6 and C9 analogs.
AID258605Antibacterial activity against Bacillus subtilis ATCC 66332006Bioorganic & medicinal chemistry letters, Jan-01, Volume: 16, Issue:1
The structure-activity relationships of mansonone F, a potent anti-MRSA sesquiterpenoid quinone: SAR studies on the C6 and C9 analogs.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (7)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's6 (85.71)29.6817
2010's1 (14.29)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.19

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.19 (24.57)
Research Supply Index2.08 (2.92)
Research Growth Index4.27 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.19)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other7 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
beta-lapachone
beta-lapachone: antineoplastic inhibitor of reverse transcriptase, DNA topoisomerase, and DNA polymerase. beta-lapachone : A benzochromenone that is 3,4-dihydro-2H-benzo[h]chromene-5,6-dione substituted by geminal methyl groups at position 2. Isolated from Tabebuia avellanedae, it exhibits antineoplastic and anti-inflammatory activities.		2.0410benzochromenone;
orthoquinones		anti-inflammatory agent;
antineoplastic agent;
plant metabolite
methicillin
Methicillin: One of the PENICILLINS which is resistant to PENICILLINASE but susceptible to a penicillin-binding protein. It is inactivated by gastric acid so administered by injection.. methicillin : A penicillin that is 6-aminopenicillanic acid in which one of the amino hydrogens is replaced by a 2,6-dimethoxybenzoyl group.		2.0310penicillin allergen;
penicillin		antibacterial drug
2-naphthol
2-naphthol: RN given refers to parent cpd. 2-naphthol : A naphthol carrying a hydroxy group at position 2.. naphthols : Any hydroxynaphthalene derivative that has a single hydroxy substituent.		2.0310naphtholantinematodal drug;
genotoxin;
human urinary metabolite;
human xenobiotic metabolite;
mouse metabolite;
radical scavenger
vancomycin
Vancomycin: Antibacterial obtained from Streptomyces orientalis. It is a glycopeptide related to RISTOCETIN that inhibits bacterial cell wall assembly and is toxic to kidneys and the inner ear.. vancomycin : A complex glycopeptide from Streptomyces orientalis. It inhibits a specific step in the synthesis of the peptidoglycan layer in the Gram-positive bacteria Staphylococcus aureus and Clostridium difficile.		2.0310glycopeptideantibacterial drug;
antimicrobial agent;
bacterial metabolite
mansonone c
mansonone C: structure in first source		2.04101,2-naphthoquinones;
sesquiterpenoid
camptothecin
NSC 100880: carboxylate (opened lactone) form of camptothecin; RN refers to (S)-isomer; structure given in first source		2.0610delta-lactone;
pyranoindolizinoquinoline;
quinoline alkaloid;
tertiary alcohol		antineoplastic agent;
EC 5.99.1.2 (DNA topoisomerase) inhibitor;
genotoxin;
plant metabolite
etoposide
[no description available]		2.0610beta-D-glucoside;
furonaphthodioxole;
organic heterotetracyclic compound		antineoplastic agent;
DNA synthesis inhibitor
alpha-lapachone
alpha-lapachone: structure in first source		2.0410organic heterotricyclic compound;
organooxygen compound
mansonone e
mansonone E: a potent anti-bacterial sesquiterpenoid isolated from the dried root bark of Ulmus pumila; structure in first source		2.4320
10-hydroxycamptothecin
[no description available]		2.0610pyranoindolizinoquinoline
sesquiterpenes
[no description available]		3.2860
naphthoquinones
Naphthoquinones: Naphthalene rings which contain two ketone moieties in any position. They can be substituted in any position except at the ketone groups.		3.2860
cytochrome c-t
Cytochromes c: Cytochromes of the c type that are found in eukaryotic MITOCHONDRIA. They serve as redox intermediates that accept electrons from MITOCHONDRIAL ELECTRON TRANSPORT COMPLEX III and transfer them to MITOCHONDRIAL ELECTRON TRANSPORT COMPLEX IV.		2.0510
ConditionIndicatedRelationship StrengthStudiesTrials
Infections, Staphylococcal
[description not available]		02.0310
Staphylococcal Infections
Infections with bacteria of the genus STAPHYLOCOCCUS.		02.0310
Lung Adenocarcinoma
[description not available]		02.0610
Nasopharyngeal Carcinoma
A carcinoma that originates in the EPITHELIUM of the NASOPHARYNX and includes four subtypes: keratinizing squamous cell, non-keratinizing, basaloid squamous cell, and PAPILLARY ADENOCARCINOMA. It is most prevalent in Southeast Asian populations and is associated with EPSTEIN-BARR VIRUS INFECTIONS. Somatic mutations associated with this cancer have been identified in NPCR, BAP1, UBAP1, ERBB2, ERBB3, MLL2, PIK3CA, KRAS, NRAS, and ARID1A genes.		02.0610
Adenocarcinoma, Basal Cell
[description not available]		02.0610
Carcinoma, Anaplastic
[description not available]		02.0610
Cancer of Lung
[description not available]		02.0610
Cancer of Nasopharynx
[description not available]		02.0610
Adenocarcinoma of Lung
A carcinoma originating in the lung and the most common lung cancer type in never-smokers. Malignant cells exhibit distinct features such as glandular epithelial, or tubular morphology. Mutations in KRAS, EGFR, BRAF, and ERBB2 genes are associated with this cancer.		02.0610
Adenocarcinoma
A malignant epithelial tumor with a glandular organization.		02.0610
Carcinoma
A malignant neoplasm made up of epithelial cells tending to infiltrate the surrounding tissues and give rise to metastases. It is a histological type of neoplasm and not a synonym for cancer.		02.0610
Lung Neoplasms
Tumors or cancer of the LUNG.		02.0610
Nasopharyngeal Neoplasms
Tumors or cancer of the NASOPHARYNX.		02.0610
Necrosis
The death of cells in an organ or tissue due to disease, injury or failure of the blood supply.		02.0510