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Beta-carbonic anhydrase 1
A protein that is a translation product of the mtcA1 gene in Mycobacterium tuberculosis H37Rv. [PRO:DNx, UniProtKB:P9WPJ7]
Synonyms
Beta-CA 1;
EC 4.2.1.1;
Carbonate dehydratase 1;
mtCA 1
Research
Bioassay Publications (12)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (33.33) | 29.6817 |
| 2010's | 8 (66.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Compounds (46)
Drugs with Inhibition Measurements
Bortezomib inhibits bacterial and fungal β-carbonic anhydrases.Bioorganic & medicinal chemistry, , 09-15, Volume: 24, Issue:18, 2016
Inhibition studies of the β-carbonic anhydrases from the bacterial pathogen Salmonella enterica serovar Typhimurium with sulfonamides and sulfamates.Bioorganic & medicinal chemistry, , Aug-15, Volume: 19, Issue:16, 2011
Natural product-based phenols as novel probes for mycobacterial and fungal carbonic anhydrases.Journal of medicinal chemistry, , Mar-24, Volume: 54, Issue:6, 2011
Inhibition of β-carbonic anhydrases with ureido-substituted benzenesulfonamides.Bioorganic & medicinal chemistry letters, , Jan-01, Volume: 21, Issue:1, 2011
Inhibition studies with anions and small molecules of two novel β-carbonic anhydrases from the bacterial pathogen Salmonella enterica serovar Typhimurium.Bioorganic & medicinal chemistry letters, , Jun-15, Volume: 21, Issue:12, 2011
Molecular cloning, characterization, and inhibition studies of the Rv1284 beta-carbonic anhydrase from Mycobacterium tuberculosis with sulfonamides and a sulfamate.Journal of medicinal chemistry, , Apr-23, Volume: 52, Issue:8, 2009
Carbonic anhydrase inhibitors. Cloning, characterization, and inhibition studies of a new beta-carbonic anhydrase from Mycobacterium tuberculosis.Journal of medicinal chemistry, , May-14, Volume: 52, Issue:9, 2009
Carbonic anhydrase inhibitors. Inhibition of the Rv1284 and Rv3273 beta-carbonic anhydrases from Mycobacterium tuberculosis with diazenylbenzenesulfonamides.Bioorganic & medicinal chemistry letters, , Sep-01, Volume: 19, Issue:17, 2009
Discovery of low nanomolar and subnanomolar inhibitors of the mycobacterial beta-carbonic anhydrases Rv1284 and Rv3273.Journal of medicinal chemistry, , Jul-09, Volume: 52, Issue:13, 2009
Tricyclic sulfonamides incorporating benzothiopyrano[4,3-c]pyrazole and pyridothiopyrano[4,3-c]pyrazole effectively inhibit α- and β-carbonic anhydrase: X-ray crystallography and solution investigations on 15 isoforms.Journal of medicinal chemistry, , Nov-26, Volume: 55, Issue:22, 2012
Molecular cloning, characterization, and inhibition studies of the Rv1284 beta-carbonic anhydrase from Mycobacterium tuberculosis with sulfonamides and a sulfamate.Journal of medicinal chemistry, , Apr-23, Volume: 52, Issue:8, 2009
Carbonic anhydrase inhibitors. Cloning, characterization, and inhibition studies of a new beta-carbonic anhydrase from Mycobacterium tuberculosis.Journal of medicinal chemistry, , May-14, Volume: 52, Issue:9, 2009
Molecular cloning, characterization, and inhibition studies of the Rv1284 beta-carbonic anhydrase from Mycobacterium tuberculosis with sulfonamides and a sulfamate.Journal of medicinal chemistry, , Apr-23, Volume: 52, Issue:8, 2009
Carbonic anhydrase inhibitors. Cloning, characterization, and inhibition studies of a new beta-carbonic anhydrase from Mycobacterium tuberculosis.Journal of medicinal chemistry, , May-14, Volume: 52, Issue:9, 2009
Molecular cloning, characterization, and inhibition studies of the Rv1284 beta-carbonic anhydrase from Mycobacterium tuberculosis with sulfonamides and a sulfamate.Journal of medicinal chemistry, , Apr-23, Volume: 52, Issue:8, 2009
Carbonic anhydrase inhibitors. Cloning, characterization, and inhibition studies of a new beta-carbonic anhydrase from Mycobacterium tuberculosis.Journal of medicinal chemistry, , May-14, Volume: 52, Issue:9, 2009
Molecular cloning, characterization, and inhibition studies of the Rv1284 beta-carbonic anhydrase from Mycobacterium tuberculosis with sulfonamides and a sulfamate.Journal of medicinal chemistry, , Apr-23, Volume: 52, Issue:8, 2009
Carbonic anhydrase inhibitors. Cloning, characterization, and inhibition studies of a new beta-carbonic anhydrase from Mycobacterium tuberculosis.Journal of medicinal chemistry, , May-14, Volume: 52, Issue:9, 2009
Carbonic anhydrase inhibitors. Inhibition of the Rv1284 and Rv3273 beta-carbonic anhydrases from Mycobacterium tuberculosis with diazenylbenzenesulfonamides.Bioorganic & medicinal chemistry letters, , Sep-01, Volume: 19, Issue:17, 2009
Molecular cloning, characterization, and inhibition studies of the Rv1284 beta-carbonic anhydrase from Mycobacterium tuberculosis with sulfonamides and a sulfamate.Journal of medicinal chemistry, , Apr-23, Volume: 52, Issue:8, 2009
Carbonic anhydrase inhibitors. Cloning, characterization, and inhibition studies of a new beta-carbonic anhydrase from Mycobacterium tuberculosis.Journal of medicinal chemistry, , May-14, Volume: 52, Issue:9, 2009
Carbonic anhydrase inhibitors. Inhibition of the Rv1284 and Rv3273 beta-carbonic anhydrases from Mycobacterium tuberculosis with diazenylbenzenesulfonamides.Bioorganic & medicinal chemistry letters, , Sep-01, Volume: 19, Issue:17, 2009
Molecular cloning, characterization, and inhibition studies of the Rv1284 beta-carbonic anhydrase from Mycobacterium tuberculosis with sulfonamides and a sulfamate.Journal of medicinal chemistry, , Apr-23, Volume: 52, Issue:8, 2009
Carbonic anhydrase inhibitors. Cloning, characterization, and inhibition studies of a new beta-carbonic anhydrase from Mycobacterium tuberculosis.Journal of medicinal chemistry, , May-14, Volume: 52, Issue:9, 2009
Inhibition of the β-class carbonic anhydrases from Mycobacterium tuberculosis with carboxylic acids.Journal of enzyme inhibition and medicinal chemistry, , Volume: 28, Issue:2, 2013
Natural product-based phenols as novel probes for mycobacterial and fungal carbonic anhydrases.Journal of medicinal chemistry, , Mar-24, Volume: 54, Issue:6, 2011
Inhibition of β-carbonic anhydrases with ureido-substituted benzenesulfonamides.Bioorganic & medicinal chemistry letters, , Jan-01, Volume: 21, Issue:1, 2011
Molecular cloning, characterization, and inhibition studies of the Rv1284 beta-carbonic anhydrase from Mycobacterium tuberculosis with sulfonamides and a sulfamate.Journal of medicinal chemistry, , Apr-23, Volume: 52, Issue:8, 2009
Carbonic anhydrase inhibitors. Cloning, characterization, and inhibition studies of a new beta-carbonic anhydrase from Mycobacterium tuberculosis.Journal of medicinal chemistry, , May-14, Volume: 52, Issue:9, 2009
Molecular cloning, characterization, and inhibition studies of the Rv1284 beta-carbonic anhydrase from Mycobacterium tuberculosis with sulfonamides and a sulfamate.Journal of medicinal chemistry, , Apr-23, Volume: 52, Issue:8, 2009
Carbonic anhydrase inhibitors. Cloning, characterization, and inhibition studies of a new beta-carbonic anhydrase from Mycobacterium tuberculosis.Journal of medicinal chemistry, , May-14, Volume: 52, Issue:9, 2009
Natural product-based phenols as novel probes for mycobacterial and fungal carbonic anhydrases.Journal of medicinal chemistry, , Mar-24, Volume: 54, Issue:6, 2011
Molecular cloning, characterization, and inhibition studies of the Rv1284 beta-carbonic anhydrase from Mycobacterium tuberculosis with sulfonamides and a sulfamate.Journal of medicinal chemistry, , Apr-23, Volume: 52, Issue:8, 2009
Carbonic anhydrase inhibitors. Cloning, characterization, and inhibition studies of a new beta-carbonic anhydrase from Mycobacterium tuberculosis.Journal of medicinal chemistry, , May-14, Volume: 52, Issue:9, 2009
Molecular cloning, characterization, and inhibition studies of the Rv1284 beta-carbonic anhydrase from Mycobacterium tuberculosis with sulfonamides and a sulfamate.Journal of medicinal chemistry, , Apr-23, Volume: 52, Issue:8, 2009
Carbonic anhydrase inhibitors. Cloning, characterization, and inhibition studies of a new beta-carbonic anhydrase from Mycobacterium tuberculosis.Journal of medicinal chemistry, , May-14, Volume: 52, Issue:9, 2009
Molecular cloning, characterization, and inhibition studies of the Rv1284 beta-carbonic anhydrase from Mycobacterium tuberculosis with sulfonamides and a sulfamate.Journal of medicinal chemistry, , Apr-23, Volume: 52, Issue:8, 2009
Carbonic anhydrase inhibitors. Cloning, characterization, and inhibition studies of a new beta-carbonic anhydrase from Mycobacterium tuberculosis.Journal of medicinal chemistry, , May-14, Volume: 52, Issue:9, 2009
Dihalogenated sulfanilamides and benzolamides are effective inhibitors of the three β-class carbonic anhydrases from Mycobacterium tuberculosis.Journal of enzyme inhibition and medicinal chemistry, , Volume: 28, Issue:2, 2013
Molecular cloning, characterization, and inhibition studies of the Rv1284 beta-carbonic anhydrase from Mycobacterium tuberculosis with sulfonamides and a sulfamate.Journal of medicinal chemistry, , Apr-23, Volume: 52, Issue:8, 2009
Carbonic anhydrase inhibitors. Cloning, characterization, and inhibition studies of a new beta-carbonic anhydrase from Mycobacterium tuberculosis.Journal of medicinal chemistry, , May-14, Volume: 52, Issue:9, 2009
Molecular cloning, characterization, and inhibition studies of the Rv1284 beta-carbonic anhydrase from Mycobacterium tuberculosis with sulfonamides and a sulfamate.Journal of medicinal chemistry, , Apr-23, Volume: 52, Issue:8, 2009
Carbonic anhydrase inhibitors. Cloning, characterization, and inhibition studies of a new beta-carbonic anhydrase from Mycobacterium tuberculosis.Journal of medicinal chemistry, , May-14, Volume: 52, Issue:9, 2009
Molecular cloning, characterization, and inhibition studies of the Rv1284 beta-carbonic anhydrase from Mycobacterium tuberculosis with sulfonamides and a sulfamate.Journal of medicinal chemistry, , Apr-23, Volume: 52, Issue:8, 2009
Carbonic anhydrase inhibitors. Cloning, characterization, and inhibition studies of a new beta-carbonic anhydrase from Mycobacterium tuberculosis.Journal of medicinal chemistry, , May-14, Volume: 52, Issue:9, 2009
Carbonic anhydrase inhibitors. Inhibition of the Rv1284 and Rv3273 beta-carbonic anhydrases from Mycobacterium tuberculosis with diazenylbenzenesulfonamides.Bioorganic & medicinal chemistry letters, , Sep-01, Volume: 19, Issue:17, 2009
Molecular cloning, characterization, and inhibition studies of the Rv1284 beta-carbonic anhydrase from Mycobacterium tuberculosis with sulfonamides and a sulfamate.Journal of medicinal chemistry, , Apr-23, Volume: 52, Issue:8, 2009
Carbonic anhydrase inhibitors. Cloning, characterization, and inhibition studies of a new beta-carbonic anhydrase from Mycobacterium tuberculosis.Journal of medicinal chemistry, , May-14, Volume: 52, Issue:9, 2009
Molecular cloning, characterization, and inhibition studies of the Rv1284 beta-carbonic anhydrase from Mycobacterium tuberculosis with sulfonamides and a sulfamate.Journal of medicinal chemistry, , Apr-23, Volume: 52, Issue:8, 2009
Carbonic anhydrase inhibitors. Cloning, characterization, and inhibition studies of a new beta-carbonic anhydrase from Mycobacterium tuberculosis.Journal of medicinal chemistry, , May-14, Volume: 52, Issue:9, 2009
Molecular cloning, characterization, and inhibition studies of the Rv1284 beta-carbonic anhydrase from Mycobacterium tuberculosis with sulfonamides and a sulfamate.Journal of medicinal chemistry, , Apr-23, Volume: 52, Issue:8, 2009
Carbonic anhydrase inhibitors. Cloning, characterization, and inhibition studies of a new beta-carbonic anhydrase from Mycobacterium tuberculosis.Journal of medicinal chemistry, , May-14, Volume: 52, Issue:9, 2009
Tricyclic sulfonamides incorporating benzothiopyrano[4,3-c]pyrazole and pyridothiopyrano[4,3-c]pyrazole effectively inhibit α- and β-carbonic anhydrase: X-ray crystallography and solution investigations on 15 isoforms.Journal of medicinal chemistry, , Nov-26, Volume: 55, Issue:22, 2012
Molecular cloning, characterization, and inhibition studies of the Rv1284 beta-carbonic anhydrase from Mycobacterium tuberculosis with sulfonamides and a sulfamate.Journal of medicinal chemistry, , Apr-23, Volume: 52, Issue:8, 2009
Carbonic anhydrase inhibitors. Cloning, characterization, and inhibition studies of a new beta-carbonic anhydrase from Mycobacterium tuberculosis.Journal of medicinal chemistry, , May-14, Volume: 52, Issue:9, 2009
Molecular cloning, characterization, and inhibition studies of the Rv1284 beta-carbonic anhydrase from Mycobacterium tuberculosis with sulfonamides and a sulfamate.Journal of medicinal chemistry, , Apr-23, Volume: 52, Issue:8, 2009
Carbonic anhydrase inhibitors. Cloning, characterization, and inhibition studies of a new beta-carbonic anhydrase from Mycobacterium tuberculosis.Journal of medicinal chemistry, , May-14, Volume: 52, Issue:9, 2009
Molecular cloning, characterization, and inhibition studies of the Rv1284 beta-carbonic anhydrase from Mycobacterium tuberculosis with sulfonamides and a sulfamate.Journal of medicinal chemistry, , Apr-23, Volume: 52, Issue:8, 2009
Carbonic anhydrase inhibitors. Cloning, characterization, and inhibition studies of a new beta-carbonic anhydrase from Mycobacterium tuberculosis.Journal of medicinal chemistry, , May-14, Volume: 52, Issue:9, 2009
Carbonic anhydrase inhibitors. Inhibition of the Rv1284 and Rv3273 beta-carbonic anhydrases from Mycobacterium tuberculosis with diazenylbenzenesulfonamides.Bioorganic & medicinal chemistry letters, , Sep-01, Volume: 19, Issue:17, 2009
Molecular cloning, characterization, and inhibition studies of the Rv1284 beta-carbonic anhydrase from Mycobacterium tuberculosis with sulfonamides and a sulfamate.Journal of medicinal chemistry, , Apr-23, Volume: 52, Issue:8, 2009
Carbonic anhydrase inhibitors. Cloning, characterization, and inhibition studies of a new beta-carbonic anhydrase from Mycobacterium tuberculosis.Journal of medicinal chemistry, , May-14, Volume: 52, Issue:9, 2009
Discovery of low nanomolar and subnanomolar inhibitors of the mycobacterial beta-carbonic anhydrases Rv1284 and Rv3273.Journal of medicinal chemistry, , Jul-09, Volume: 52, Issue:13, 2009
Molecular cloning, characterization, and inhibition studies of the Rv1284 beta-carbonic anhydrase from Mycobacterium tuberculosis with sulfonamides and a sulfamate.Journal of medicinal chemistry, , Apr-23, Volume: 52, Issue:8, 2009
Carbonic anhydrase inhibitors. Cloning, characterization, and inhibition studies of a new beta-carbonic anhydrase from Mycobacterium tuberculosis.Journal of medicinal chemistry, , May-14, Volume: 52, Issue:9, 2009
Carbonic anhydrase inhibitors. Inhibition of the Rv1284 and Rv3273 beta-carbonic anhydrases from Mycobacterium tuberculosis with diazenylbenzenesulfonamides.Bioorganic & medicinal chemistry letters, , Sep-01, Volume: 19, Issue:17, 2009
Natural product-based phenols as novel probes for mycobacterial and fungal carbonic anhydrases.Journal of medicinal chemistry, , Mar-24, Volume: 54, Issue:6, 2011
Molecular cloning, characterization, and inhibition studies of the Rv1284 beta-carbonic anhydrase from Mycobacterium tuberculosis with sulfonamides and a sulfamate.Journal of medicinal chemistry, , Apr-23, Volume: 52, Issue:8, 2009
Carbonic anhydrase inhibitors. Cloning, characterization, and inhibition studies of a new beta-carbonic anhydrase from Mycobacterium tuberculosis.Journal of medicinal chemistry, , May-14, Volume: 52, Issue:9, 2009