Uridine phosphorylase 1

A uridine phosphorylase 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q16831]

Synonyms

UPase 1;
UrdPase 1;
EC 2.4.2.3

Research

Bioassay Publications (2)

Timeframe	Studies on this Protein(%)	All Drugs %
pre-1990	1 (50.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	1 (50.00)	24.3611
2020's	0 (0.00)	2.80

Compounds (4)

Drugs with Activation Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
5-benzylacyclouridine	Homo sapiens (human)	Kd	2.6000	4	4
3-cyano-6-hydroxy-4-methyl-2-pyridone	Homo sapiens (human)	Kd	3.3650	4	4
2,6-dihydroxy-3-cyanopyridine	Homo sapiens (human)	Kd	1.0450	3	3

Drugs with Other Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
doxifluridine	Homo sapiens (human)	Km	6,000.0000	1	1
5-benzylacyclouridine	Homo sapiens (human)	Kii	0.2235	2	2
5-benzylacyclouridine	Homo sapiens (human)	Kis	0.5470	1	1
3-cyano-6-hydroxy-4-methyl-2-pyridone	Homo sapiens (human)	Kii	0.4835	2	2
3-cyano-6-hydroxy-4-methyl-2-pyridone	Homo sapiens (human)	Kis	0.3750	1	1
2,6-dihydroxy-3-cyanopyridine	Homo sapiens (human)	Kii	1.6060	2	2
2,6-dihydroxy-3-cyanopyridine	Homo sapiens (human)	Kis	1.5875	2	2

Enables

This protein enables 4 target(s):

Target	Category	Definition
uridine phosphorylase activity	molecular function	Catalysis of the reaction: uridine + phosphate = uracil + alpha-D-ribose 1-phosphate. [EC:2.4.2.3]
thymidine phosphorylase activity	molecular function	Catalysis of the reaction: thymidine + phosphate = thymine + 2-deoxy-D-ribose 1-phosphate. [RHEA:16037]
identical protein binding	molecular function	Binding to an identical protein or proteins. [GOC:jl]
deoxyuridine phosphorylase activity	molecular function	Catalysis of the reaction: 2'-deoxyuridine + phosphate = 2-deoxy-alpha-D-ribose 1-phosphate + uracil. [RHEA:22824]

Located In

This protein is located in 2 target(s):

Target	Category	Definition
nucleoplasm	cellular component	That part of the nuclear content other than the chromosomes or the nucleolus. [GOC:ma, ISBN:0124325653]
cytosol	cellular component	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]

Active In

This protein is active in 1 target(s):

Target	Category	Definition
cytosol	cellular component	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]

Involved In

This protein is involved in 9 target(s):

Target	Category	Definition
nucleobase-containing compound metabolic process	biological process	Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids. [GOC:ai]
uridine catabolic process	biological process	The chemical reactions and pathways resulting in the breakdown of uridine, uracil riboside, a ribonucleoside very widely distributed but occurring almost entirely as phosphoric esters in ribonucleotides and ribonucleic acids. [GOC:go_curators]
CMP catabolic process	biological process	The chemical reactions and pathways resulting in the breakdown of CMP, cytidine monophosphate. [ISBN:0198506732]
dCMP catabolic process	biological process	The chemical reactions and pathways resulting in the breakdown of dCMP, deoxycytidine monophosphate. [ISBN:0198506732]
cellular response to glucose starvation	biological process	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of glucose. [GOC:jl]
UMP salvage	biological process	Any process which produces UMP, uridine monophosphate, from derivatives of it (e.g. cytidine, uridine, cytosine) without de novo synthesis. [GOC:ecd, PMID:15096496]
UMP catabolic process	biological process	The chemical reactions and pathways resulting in the breakdown of UMP, uridine monophosphate. [GOC:go_curators]
dTMP catabolic process	biological process	The chemical reactions and pathways resulting in the breakdown of dTMP, deoxyribosylthymine monophosphate. [GOC:go_curators]
dUMP catabolic process	biological process	The chemical reactions and pathways resulting in the breakdown of dUMP, deoxyuridine (5'-)monophosphate. [GOC:go_curators]