Page last updated: 2024-08-07 13:34:18
Uridine phosphorylase 1
A uridine phosphorylase 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q16831]
Synonyms
UPase 1;
UrdPase 1;
EC 2.4.2.3
Research
Bioassay Publications (2)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 1 (50.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Compounds (4)
Drugs with Activation Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| 5-benzylacyclouridine | Homo sapiens (human) | Kd | 2.6000 | 4 | 4 |
| 3-cyano-6-hydroxy-4-methyl-2-pyridone | Homo sapiens (human) | Kd | 3.3650 | 4 | 4 |
| 2,6-dihydroxy-3-cyanopyridine | Homo sapiens (human) | Kd | 1.0450 | 3 | 3 |
Drugs with Other Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| doxifluridine | Homo sapiens (human) | Km | 6,000.0000 | 1 | 1 |
| 5-benzylacyclouridine | Homo sapiens (human) | Kii | 0.2235 | 2 | 2 |
| 5-benzylacyclouridine | Homo sapiens (human) | Kis | 0.5470 | 1 | 1 |
| 3-cyano-6-hydroxy-4-methyl-2-pyridone | Homo sapiens (human) | Kii | 0.4835 | 2 | 2 |
| 3-cyano-6-hydroxy-4-methyl-2-pyridone | Homo sapiens (human) | Kis | 0.3750 | 1 | 1 |
| 2,6-dihydroxy-3-cyanopyridine | Homo sapiens (human) | Kii | 1.6060 | 2 | 2 |
| 2,6-dihydroxy-3-cyanopyridine | Homo sapiens (human) | Kis | 1.5875 | 2 | 2 |
Enables
This protein enables 4 target(s):
| Target | Category | Definition |
|---|---|---|
| uridine phosphorylase activity | molecular function | Catalysis of the reaction: uridine + phosphate = uracil + alpha-D-ribose 1-phosphate. [EC:2.4.2.3] |
| thymidine phosphorylase activity | molecular function | Catalysis of the reaction: thymidine + phosphate = thymine + 2-deoxy-D-ribose 1-phosphate. [RHEA:16037] |
| identical protein binding | molecular function | Binding to an identical protein or proteins. [GOC:jl] |
| deoxyuridine phosphorylase activity | molecular function | Catalysis of the reaction: 2'-deoxyuridine + phosphate = 2-deoxy-alpha-D-ribose 1-phosphate + uracil. [RHEA:22824] |
Located In
This protein is located in 2 target(s):
| Target | Category | Definition |
|---|---|---|
| nucleoplasm | cellular component | That part of the nuclear content other than the chromosomes or the nucleolus. [GOC:ma, ISBN:0124325653] |
| cytosol | cellular component | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl] |
Active In
This protein is active in 1 target(s):
| Target | Category | Definition |
|---|---|---|
| cytosol | cellular component | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl] |
Involved In
This protein is involved in 9 target(s):
| Target | Category | Definition |
|---|---|---|
| nucleobase-containing compound metabolic process | biological process | Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids. [GOC:ai] |
| uridine catabolic process | biological process | The chemical reactions and pathways resulting in the breakdown of uridine, uracil riboside, a ribonucleoside very widely distributed but occurring almost entirely as phosphoric esters in ribonucleotides and ribonucleic acids. [GOC:go_curators] |
| CMP catabolic process | biological process | The chemical reactions and pathways resulting in the breakdown of CMP, cytidine monophosphate. [ISBN:0198506732] |
| dCMP catabolic process | biological process | The chemical reactions and pathways resulting in the breakdown of dCMP, deoxycytidine monophosphate. [ISBN:0198506732] |
| cellular response to glucose starvation | biological process | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of glucose. [GOC:jl] |
| UMP salvage | biological process | Any process which produces UMP, uridine monophosphate, from derivatives of it (e.g. cytidine, uridine, cytosine) without de novo synthesis. [GOC:ecd, PMID:15096496] |
| UMP catabolic process | biological process | The chemical reactions and pathways resulting in the breakdown of UMP, uridine monophosphate. [GOC:go_curators] |
| dTMP catabolic process | biological process | The chemical reactions and pathways resulting in the breakdown of dTMP, deoxyribosylthymine monophosphate. [GOC:go_curators] |
| dUMP catabolic process | biological process | The chemical reactions and pathways resulting in the breakdown of dUMP, deoxyuridine (5'-)monophosphate. [GOC:go_curators] |