chlorzoxazone has been researched along with Necrosis in 2 studies
Chlorzoxazone: A centrally acting central muscle relaxant with sedative properties. It is claimed to inhibit muscle spasm by exerting an effect primarily at the level of the spinal cord and subcortical areas of the brain. (From Martindale, The Extra Pharmacopoea, 30th ed, p1202)
chlorzoxazone : A member of the class of 1,3-benzoxazoles that is 1,3-benzoxazol-2-ol in which the hydrogen atom at position 5 is substituted by chlorine. A centrally acting muscle relaxant with sedative properties, it is used for the symptomatic treatment of painful muscle spasm.
Necrosis: The death of cells in an organ or tissue due to disease, injury or failure of the blood supply.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The necrosis was predominantly localised in the intermediate zone of the hepatic lobules with vacuolisation of the centrilobular zones." | 1.31 | Potentiation of 2,2-dichloro-1,1,1-trifluoroethane (HCFC-123)-induced liver toxicity by ethanol in guinea-pigs. ( Buchet, JP; Haufroid, V; Hoet, P; Lison, D; Rahier, J; Sempoux, C, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (50.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (50.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hoet, P | 1 |
| Buchet, JP | 1 |
| Sempoux, C | 1 |
| Haufroid, V | 1 |
| Rahier, J | 1 |
| Lison, D | 1 |
| Powers, BJ | 1 |
| Cattau, EL | 1 |
| Zimmerman, HJ | 1 |
1 review available for chlorzoxazone and Necrosis
| Article | Year |
|---|---|
Chlorzoxazone hepatotoxic reactions. An analysis of 21 identified or presumed cases.
Topics: Acetaminophen; Adult; Aged; Benzoxazoles; Biopsy; Chlorzoxazone; Drug Combinations; Drug Evaluation; | 1986 |
1 other study available for chlorzoxazone and Necrosis
| Article | Year |
|---|---|
Potentiation of 2,2-dichloro-1,1,1-trifluoroethane (HCFC-123)-induced liver toxicity by ethanol in guinea-pigs.
Topics: Administration, Inhalation; Administration, Oral; Alanine Transaminase; Animals; Animals, Outbred St | 2002 |