Page last updated: 2024-08-07 20:55:25

Sialin

A sialin that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NRA2]

Synonyms

H(+)/nitrate cotransporter;
H(+)/sialic acid cotransporter;
AST;
Membrane glycoprotein HP59;
Solute carrier family 17 member 5;
Vesicular H(+)/Aspartate-glutamate cotransporter

Research

Bioassay Publications (1)

Timeframe	Studies on this Protein(%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	1 (100.00)	2.80

Compounds (2)

Drugs with Inhibition Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
fr 139317	Homo sapiens (human)	Ki	20.0000	1	1
n-(fluorenyl-9-methoxycarbonyl)leucine	Homo sapiens (human)	IC50	23.3000	1	1
n-(fluorenyl-9-methoxycarbonyl)leucine	Homo sapiens (human)	Ki	10.2000	1	1

Drugs with Other Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
n-(fluorenyl-9-methoxycarbonyl)leucine	Homo sapiens (human)	Km	1,300.0000	1	1

Enables

This protein enables 4 target(s):

Target	Category	Definition
carbohydrate:proton symporter activity	molecular function	Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: carbohydrate(out) + H+(out) = carbohydrate(in) + H+(in). [TC:2.A.1.1]
sialic acid transmembrane transporter activity	molecular function	Enables the transfer of sialic acid from one side of a membrane to the other. [GOC:jl, GOC:mtg_transport, ISBN:0815340729]
sialic acid:proton symporter activity	molecular function	Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sialate(out) + H+(out) = sialate(in) + H+(in). [TC:2.A.1.12.1]
D-glucuronate transmembrane transporter activity	molecular function	Enables the transfer of D-glucuronate, the D-enantiomer of glucuronate, from one side of a membrane to the other. [GOC:jl, GOC:jsg, GOC:mah, GOC:mtg_transport, ISBN:0198506732, ISBN:0815340729]

Located In

This protein is located in 6 target(s):

Target	Category	Definition
lysosomal membrane	cellular component	The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm. [GOC:ai]
cytosol	cellular component	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]
plasma membrane	cellular component	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]
membrane	cellular component	A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. [GOC:dos, GOC:mah, ISBN:0815316194]
basolateral plasma membrane	cellular component	The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis. [GOC:go_curators]
synaptic vesicle membrane	cellular component	The lipid bilayer surrounding a synaptic vesicle. [GOC:mah]

Active In

This protein is active in 2 target(s):

Target	Category	Definition
plasma membrane	cellular component	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]
lysosome	cellular component	A small lytic vacuole that has cell cycle-independent morphology found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions. [GOC:mah, ISBN:0198506732]

Involved In

This protein is involved in 8 target(s):

Target	Category	Definition
monoatomic ion transport	biological process	The directed movement of a monoatomic ion into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Monatomic ions (also called simple ions) are ions consisting of exactly one atom. [GOC:ai]
amino acid transport	biological process	The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai]
response to bacterium	biological process	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a bacterium. [GOC:hb]
carbohydrate transmembrane transport	biological process	The process in which a carbohydrate is transported across a membrane. [GOC:mah]
D-glucuronate transmembrane transport	biological process	The process in which D-glucuronate, the D-enantiomer of glucuronate, is transported across a lipid bilayer, from one side of a membrane to the other. [GOC:jl, GOC:jsg, GOC:mah]
proton transmembrane transport	biological process	The directed movement of a proton across a membrane. [GO_REF:0000069, GOC:pr, GOC:TermGenie]
sialic acid transport	biological process	The directed movement of sialic acid into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:krc]
monoatomic anion transport	biological process	The directed movement of a monoatomic anion, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Monatomic anions (also called simple anions) are negatively charged ions consisting of exactly one atom. [GOC:ai]