Proteins > Proton-coupled amino acid transporter 1
Page last updated: 2024-08-08 00:37:17
Proton-coupled amino acid transporter 1
A proton-coupled amino acid transporter 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q7Z2H8]
Synonyms
Proton/amino acid transporter 1;
hPAT1;
Solute carrier family 36 member 1
Research
Bioassay Publications (1)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Compounds (39)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| gamma-aminobutyric acid | Homo sapiens (human) | Ki | 4,000.0000 | 1 | 1 |
| beta-alanine | Homo sapiens (human) | Ki | 2,400.0000 | 1 | 1 |
| betaine | Homo sapiens (human) | Ki | 1,900.0000 | 1 | 1 |
| aminocaproic acid | Homo sapiens (human) | Ki | 35,000.0000 | 1 | 1 |
| creatine | Homo sapiens (human) | Ki | 3,200.0000 | 1 | 1 |
| glycine | Homo sapiens (human) | Ki | 5,100.0000 | 1 | 1 |
| glycocyamine | Homo sapiens (human) | Ki | 1,500.0000 | 1 | 1 |
| picolinic acid | Homo sapiens (human) | Ki | 18,000.0000 | 1 | 1 |
| sarcosine | Homo sapiens (human) | Ki | 1,900.0000 | 1 | 1 |
| taurine | Homo sapiens (human) | Ki | 7,800.0000 | 1 | 1 |
| tramiprosate | Homo sapiens (human) | Ki | 7,100.0000 | 1 | 1 |
| isoguvacine | Homo sapiens (human) | Ki | 5,800.0000 | 1 | 1 |
| 4-piperidinecarboxylic acid | Homo sapiens (human) | Ki | 2,300.0000 | 1 | 1 |
| hydroxyproline | Homo sapiens (human) | Ki | 9,000.0000 | 1 | 1 |
| cysteine | Homo sapiens (human) | Ki | 46,000.0000 | 1 | 1 |
| alanine | Homo sapiens (human) | Ki | 2,800.0000 | 1 | 1 |
| serine | Homo sapiens (human) | Ki | 35,000.0000 | 1 | 1 |
| leucine | Homo sapiens (human) | Ki | 100,000.0000 | 1 | 1 |
| 2-aminoisobutyric acid | Homo sapiens (human) | Ki | 23,000.0000 | 1 | 1 |
| cycloserine | Homo sapiens (human) | Ki | 4,400.0000 | 1 | 1 |
| isoleucine | Homo sapiens (human) | Ki | 37,000.0000 | 1 | 1 |
| 3-aminobenzoic acid | Homo sapiens (human) | Ki | 12,000.0000 | 1 | 1 |
| piperidine | Homo sapiens (human) | Ki | 54,000.0000 | 1 | 1 |
| D-proline | Homo sapiens (human) | Ki | 1,200.0000 | 1 | 1 |
| 4-hydroxybutyric acid | Homo sapiens (human) | Ki | 65,000.0000 | 1 | 1 |
| thiazolidines | Homo sapiens (human) | Ki | 44,000.0000 | 1 | 1 |
| azetidyl-2-carboxylic acid | Homo sapiens (human) | Ki | 1,800.0000 | 1 | 1 |
| pyrrolidine | Homo sapiens (human) | Ki | 38,000.0000 | 1 | 1 |
| norvaline | Homo sapiens (human) | Ki | 46,000.0000 | 1 | 1 |
| guanidinopropionic acid | Homo sapiens (human) | Ki | 1,300.0000 | 1 | 1 |
| D-serine | Homo sapiens (human) | Ki | 22,000.0000 | 1 | 1 |
| D-alanine | Homo sapiens (human) | Ki | 19,000.0000 | 1 | 1 |
| D-valine | Homo sapiens (human) | Ki | 100,000.0000 | 1 | 1 |
| 2-(methylamino)isobutyric acid | Homo sapiens (human) | Ki | 2,200.0000 | 1 | 1 |
| thiazolidine-4-carboxylic acid, (r)-isomer | Homo sapiens (human) | Ki | 7,900.0000 | 1 | 1 |
| proline | Homo sapiens (human) | Ki | 1,600.0000 | 1 | 1 |
| L-cycloserine | Homo sapiens (human) | Ki | 7,400.0000 | 1 | 1 |
| prolinol | Homo sapiens (human) | Ki | 50,000.0000 | 1 | 1 |
| n-methylalanine | Homo sapiens (human) | Ki | 2,200.0000 | 1 | 1 |
Drugs with Other Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| leucine | Homo sapiens (human) | pKi | 2,000.0000 | 1 | 1 |
Enables
This protein enables 9 target(s):
| Target | Category | Definition |
|---|
| amino acid:proton symporter activity | molecular function | Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: amino acid(out) + H+(out) = amino acid(in) + H+(in). [GOC:ai] |
| proline:proton symporter activity | molecular function | Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: proline(out) + H+(out) = proline(in) + H+(in). [GOC:ai] |
| taurine transmembrane transporter activity | molecular function | Enables the transfer of taurine from one side of a membrane to the other. Taurine (2-aminoethanesulfonic acid) is a sulphur-containing amino acid derivative which is important in the metabolism of fats. [GOC:ai] |
| protein binding | molecular function | Binding to a protein. [GOC:go_curators] |
| amino acid transmembrane transporter activity | molecular function | Enables the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group. [GOC:ai, GOC:mtg_transport, ISBN:0815340729] |
| alanine transmembrane transporter activity | molecular function | Enables the transfer of alanine from one side of a membrane to the other. Alanine is 2-aminopropanoic acid. [GOC:mtg_transport, ISBN:0815340729] |
| L-alanine transmembrane transporter activity | molecular function | Enables the transfer of L-alanine from one side of a membrane to the other. L-alanine is the L-enantiomer of 2-aminopropanoic acid. [GOC:go_curators, GOC:jsg, GOC:mah, GOC:mtg_transport, ISBN:0198506732, ISBN:0815340729] |
| L-proline transmembrane transporter activity | molecular function | Enables the transfer of L-proline from one side of a membrane to the other. L-proline is pyrrolidine-2-carboxylic acid. [GOC:ai, GOC:mtg_transport, ISBN:0815340729] |
| glycine transmembrane transporter activity | molecular function | Enables the transfer of glycine from one side of a membrane to the other. Glycine is aminoethanoic acid. [GOC:ai] |
Located In
This protein is located in 4 target(s):
| Target | Category | Definition |
|---|
| lysosomal membrane | cellular component | The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm. [GOC:ai] |
| endoplasmic reticulum | cellular component | The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). [ISBN:0198506732] |
| plasma membrane | cellular component | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363] |
| apical plasma membrane | cellular component | The region of the plasma membrane located at the apical end of the cell. [GOC:curators] |
Active In
This protein is active in 1 target(s):
| Target | Category | Definition |
|---|
| vacuolar membrane | cellular component | The lipid bilayer surrounding the vacuole and separating its contents from the cytoplasm of the cell. [GOC:ai] |
Involved In
This protein is involved in 10 target(s):
| Target | Category | Definition |
|---|
| monoatomic ion transport | biological process | The directed movement of a monoatomic ion into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Monatomic ions (also called simple ions) are ions consisting of exactly one atom. [GOC:ai] |
| amino acid transport | biological process | The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai] |
| taurine transmembrane transport | biological process | The directed movement of taurine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:krc] |
| proline transport | biological process | The directed movement of proline, pyrrolidine-2-carboxylic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai] |
| alanine transport | biological process | The directed movement of alanine, 2-aminopropanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:mah] |
| amino acid import across plasma membrane | biological process | The directed movement of an amino acid from outside of a cell, across the plasma membrane and into the cytosol. [GOC:krc, PMID:8195186] |
| glycine transport | biological process | The directed movement of glycine, aminoethanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai] |
| proline transmembrane transport | biological process | The directed movement of proline, pyrrolidine-2-carboxylic acid, across a membrane by means of some agent such as a transporter or pore. [GOC:vw] |
| proton transmembrane transport | biological process | The directed movement of a proton across a membrane. [GO_REF:0000069, GOC:pr, GOC:TermGenie] |
| L-alanine transport | biological process | The directed movement of L-alanine, the L-enantiomer of 2-aminopropanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai, GOC:jsg, GOC:mah] |