Proteins > Voltage-dependent L-type calcium channel subunit alpha-1C
Page last updated: 2024-08-07 17:06:46

Voltage-dependent L-type calcium channel subunit alpha-1C

A voltage-dependent L-type calcium channel subunit alpha-1C that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q13936]

Synonyms

Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle;
Voltage-gated calcium channel subunit alpha Cav1.2

Research

Bioassay Publications (24)

TimeframeStudies on this Protein(%)All Drugs %
pre-19902 (8.33)18.7374
1990's2 (8.33)18.2507
2000's2 (8.33)29.6817
2010's16 (66.67)24.3611
2020's2 (8.33)2.80

Compounds (103)

Drugs with Inhibition Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
gallopamilHomo sapiens (human)IC500.014022
gallopamilHomo sapiens (human)Ki0.005411
phenytoinHomo sapiens (human)IC5073.450022
tacrineHomo sapiens (human)IC5017.000011
alfuzosinHomo sapiens (human)IC50199.526011
amiodaroneHomo sapiens (human)IC501.085022
amitriptylineHomo sapiens (human)IC5011.600011
amlodipineHomo sapiens (human)IC502.700022
astemizoleHomo sapiens (human)IC501.100011
bepridilHomo sapiens (human)IC501.200022
verapamilHomo sapiens (human)IC5024.141766
chlorpromazineHomo sapiens (human)IC503.400011
cifenlineHomo sapiens (human)IC5030.000011
cilostazolHomo sapiens (human)IC5091.200011
cisaprideHomo sapiens (human)IC5011.800011
clotrimazoleHomo sapiens (human)IC500.590011
diazepamHomo sapiens (human)IC5030.500011
disopyramideHomo sapiens (human)IC501,036.700011
donepezilHomo sapiens (human)IC5034.300011
droperidolHomo sapiens (human)IC507.600011
flecainideHomo sapiens (human)IC5027.100011
haloperidolHomo sapiens (human)IC501.500022
halothaneHomo sapiens (human)IC508,150.000022
imipramineHomo sapiens (human)IC508.300011
1-methyl-3-isobutylxanthineHomo sapiens (human)IC50466.000011
isradipineHomo sapiens (human)IC500.002211
lamotrigineHomo sapiens (human)IC501,421.910022
loratadineHomo sapiens (human)IC5011.400011
methadoneHomo sapiens (human)IC5037.400011
metronidazoleHomo sapiens (human)IC50177.900011
mexiletineHomo sapiens (human)IC50100.000011
mitoxantroneHomo sapiens (human)IC5022.500011
nicardipineHomo sapiens (human)IC5011.316733
nifedipineHomo sapiens (human)IC503.699566
nifedipineHomo sapiens (human)Ki0.010223
nimodipineHomo sapiens (human)IC504.713333
nisoldipineHomo sapiens (human)IC500.003011
nitrendipineHomo sapiens (human)IC500.015222
nitrendipineHomo sapiens (human)Ki0.000211
pentobarbitalHomo sapiens (human)IC50299.000011
procainamideHomo sapiens (human)IC50389.500011
propranololHomo sapiens (human)IC5021.000011
risperidoneHomo sapiens (human)IC5079.600022
sotalolHomo sapiens (human)IC50608.150022
terfenadineHomo sapiens (human)IC501.125022
thioridazineHomo sapiens (human)IC502.410022
trimethoprimHomo sapiens (human)IC5034.000011
pimozideHomo sapiens (human)IC500.201022
terodilineHomo sapiens (human)IC504.800011
halofantrineHomo sapiens (human)IC501.900011
ribavirinHomo sapiens (human)IC50622.500011
diltiazemHomo sapiens (human)IC5015.070033
pinaveriumHomo sapiens (human)IC501.750011
piperacillinHomo sapiens (human)IC501,226.000011
paroxetineHomo sapiens (human)IC503.900011
lidamidineHomo sapiens (human)IC5030.000011
sertindoleHomo sapiens (human)IC507.600022
sparfloxacinHomo sapiens (human)IC5088.800011
mibefradilHomo sapiens (human)IC5066.186366
ibutilideHomo sapiens (human)IC5062.500011
lamivudineHomo sapiens (human)IC5054.200011
duloxetineHomo sapiens (human)IC5042.639633
nebivololHomo sapiens (human)IC5015.848911
uk 68798Homo sapiens (human)IC50317.047244
voriconazoleHomo sapiens (human)IC50414.200011
doripenemHomo sapiens (human)IC501.995311
tadalafilHomo sapiens (human)IC50398.107011
paliperidoneHomo sapiens (human)IC50530.669033
moxifloxacinHomo sapiens (human)IC50246.669033
solifenacinHomo sapiens (human)IC505.304822
telbivudineHomo sapiens (human)IC50713.900011
cyc 202Homo sapiens (human)IC5023.400011
lapatinibHomo sapiens (human)IC508,922.080022
darunavirHomo sapiens (human)IC501,584.890011
deferasiroxHomo sapiens (human)IC501,000.000011
lacosamideHomo sapiens (human)IC5050.118711
quinidineHomo sapiens (human)IC5013.110022
saquinavirHomo sapiens (human)IC501.900011
linezolidHomo sapiens (human)IC50105.400011
mepirodipineHomo sapiens (human)IC502.150022
tolterodineHomo sapiens (human)IC5025.118911
darifenacinHomo sapiens (human)IC501,584.890011
s 1033Homo sapiens (human)IC501,122.168733
dasatinibHomo sapiens (human)IC50243.465333
sitagliptinHomo sapiens (human)IC5050,073.550022
np 118809Homo sapiens (human)IC5012.200011
cilnidipineHomo sapiens (human)IC509.000022
l 745870Homo sapiens (human)IC509.000011
silodosinHomo sapiens (human)IC50794.328011
su 11248Homo sapiens (human)IC50104.119633
ceftriaxoneHomo sapiens (human)IC50153.800011
alvimopan anhydrousHomo sapiens (human)IC505.011911
palonosetronHomo sapiens (human)IC50398.107011
lu 208075Homo sapiens (human)IC502,511.890011
ith 4012Homo sapiens (human)IC5020.000011
mk-3102Homo sapiens (human)IC5030.000022
raltegravirHomo sapiens (human)IC50246.700011
mk-8825Homo sapiens (human)IC5020.000011
trv130Homo sapiens (human)IC5036.000011
ajmalineHomo sapiens (human)IC5071.000011
clozapineHomo sapiens (human)IC503.600011
sildenafilHomo sapiens (human)IC50100.000011
vardenafilHomo sapiens (human)IC50133.519022
thiamet gHomo sapiens (human)IC5030.000011

Drugs with Activation Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
sumatriptanHomo sapiens (human)EC500.012011
l 772405Homo sapiens (human)EC500.000811

Drugs with Other Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
nifedipineHomo sapiens (human)ID500.010012

Enables

This protein enables 8 target(s):

TargetCategoryDefinition
voltage-gated calcium channel activitymolecular functionEnables the transmembrane transfer of a calcium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. [GOC:mtg_transport, GOC:tb, ISBN:0815340729]
protein bindingmolecular functionBinding to a protein. [GOC:go_curators]
calmodulin bindingmolecular functionBinding to calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states. [GOC:krc]
high voltage-gated calcium channel activitymolecular functionEnables the transmembrane transfer of a calcium ion by a high voltage-gated channel. A high voltage-gated channel is a channel whose open state is dependent on high voltage across the membrane in which it is embedded. [GOC:mtg_transport, ISBN:0815340729, PMID:16382099]
metal ion bindingmolecular functionBinding to a metal ion. [GOC:ai]
alpha-actinin bindingmolecular functionBinding to alpha-actinin, one of a family of proteins that cross-link F-actin as antiparallel homodimers. Alpha-actinin has a molecular mass of 93-103 KDa; at the N-terminus there are two calponin homology domains, at the C-terminus there are two EF-hands. These two domains are connected by the rod domain. This domain is formed by triple-helical spectrin repeats. [PMID:10984498, PMID:11699871, PMID:15014165]
voltage-gated calcium channel activity involved in cardiac muscle cell action potentialmolecular functionEnables the transmembrane transfer of a calcium ion by a voltage-gated channel across the plasma membrane of a cardiac muscle cell that contributes to the depolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
voltage-gated calcium channel activity involved in AV node cell action potentialmolecular functionEnables the transmembrane transfer of a calcium ion by a voltage-gated channel across the plasma membrane of an AV node cardiac muscle cell that contributes to the depolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]

Located In

This protein is located in 8 target(s):

TargetCategoryDefinition
cytoplasmcellular componentThe contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684]
plasma membranecellular componentThe membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]
postsynaptic densitycellular componentAn electron dense network of proteins within and adjacent to the postsynaptic membrane of an asymmetric, neuron-neuron synapse. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize them such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components. [GOC:BHF, GOC:dos, GOC:ef, GOC:jid, GOC:pr, GOC:sjp, http://molneuro.kaist.ac.kr/psd, PMID:14532281, Wikipedia:Postsynaptic_density]
membranecellular componentA lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. [GOC:dos, GOC:mah, ISBN:0815316194]
Z disccellular componentPlatelike region of a muscle sarcomere to which the plus ends of actin filaments are attached. [GOC:mtg_muscle, ISBN:0815316194]
dendritecellular componentA neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body. [GOC:aruk, GOC:bc, GOC:dos, GOC:mah, GOC:nln, ISBN:0198506732]
perikaryoncellular componentThe portion of the cell soma (neuronal cell body) that excludes the nucleus. [GOC:jl]
postsynaptic density membranecellular componentThe membrane component of the postsynaptic density. This is the region of the postsynaptic membrane in which the population of neurotransmitter receptors involved in synaptic transmission are concentrated. [GOC:dos]

Part Of

This protein is part of 2 target(s):

TargetCategoryDefinition
L-type voltage-gated calcium channel complexcellular componentA type of voltage-dependent calcium channel responsible for excitation-contraction coupling of skeletal, smooth, and cardiac muscle. 'L' stands for 'long-lasting' referring to the length of activation. [GOC:ame, PMID:12946355]
voltage-gated calcium channel complexcellular componentA protein complex that forms a transmembrane channel through which calcium ions may pass in response to changes in membrane potential. [GOC:mah]

Involved In

This protein is involved in 20 target(s):

TargetCategoryDefinition
immune system developmentbiological processThe process whose specific outcome is the progression of an organismal system whose objective is to provide calibrated responses by an organism to a potential internal or invasive threat, over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process. [GOC:add, GOC:dph]
positive regulation of cytosolic calcium ion concentrationbiological processAny process that increases the concentration of calcium ions in the cytosol. [GOC:ai]
heart developmentbiological processThe process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood. [GOC:jid, UBERON:0000948]
regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ionbiological processAny process that modulates the frequency, rate or extent of cardiac muscle contraction via the regulation of the release of sequestered calcium ion by sarcoplasmic reticulum into cytosol. The sarcoplasmic reticulum is the endoplasmic reticulum of striated muscle, specialised for the sequestration of calcium ions that are released upon receipt of a signal relayed by the T tubules from the neuromuscular junction. [GOC:BHF, GOC:dph, GOC:tb]
embryonic forelimb morphogenesisbiological processThe process, occurring in the embryo, by which the anatomical structures of the forelimb are generated and organized. The forelimbs are the front limbs of an animal, e.g. the arms of a human. [ISBN:0198612001]
camera-type eye developmentbiological processThe process whose specific outcome is the progression of the camera-type eye over time, from its formation to the mature structure. The camera-type eye is an organ of sight that receives light through an aperture and focuses it through a lens, projecting it on a photoreceptor field. [GOC:go_curators, GOC:mtg_sensu]
positive regulation of adenylate cyclase activitybiological processAny process that activates or increases the frequency, rate or extent of adenylate cyclase activity. [GOC:go_curators]
positive regulation of muscle contractionbiological processAny process that activates or increases the frequency, rate or extent of muscle contraction. [GOC:go_curators]
calcium ion transport into cytosolbiological processThe directed movement of calcium ions (Ca2+) into the cytosol. [GOC:dph, GOC:tb]
cardiac conductionbiological processTransfer of an organized electrical impulse across the heart to coordinate the contraction of cardiac muscles. The process begins with generation of an action potential (in the sinoatrial node (SA) in humans) and ends with a change in the rate, frequency, or extent of the contraction of the heart muscles. [GOC:dph]
calcium ion transmembrane transport via high voltage-gated calcium channelbiological processA process in which a calcium ion is transported from one side of a membrane to the other by means of a high voltage-gated calcium channel. [GOC:dph]
calcium ion transmembrane transportbiological processA process in which a calcium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore. [GOC:mah]
cardiac muscle cell action potential involved in contractionbiological processAn action potential that occurs in a cardiac muscle cell and is involved in its contraction. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
membrane depolarization during cardiac muscle cell action potentialbiological processThe process in which cardiac muscle cell membrane potential changes in the depolarizing direction from the negative resting potential towards the positive membrane potential that will be the peak of the action potential. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
membrane depolarization during AV node cell action potentialbiological processThe process in which AV node cardiac muscle cell membrane potential changes in the depolarizing direction from the negative resting potential towards the positive membrane potential that will be the peak of the action potential. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
cell communication by electrical coupling involved in cardiac conductionbiological processThe process that mediates signaling interactions between one cell and another cell by transfer of current between their adjacent cytoplasms via intercellular protein channels and contributes to the process of cardiac conduction. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
regulation of heart rate by cardiac conductionbiological processA cardiac conduction process that modulates the frequency or rate of heart contraction. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
regulation of ventricular cardiac muscle cell action potentialbiological processAny process that modulates the frequency, rate or extent of action potential creation, propagation or termination in a ventricular cardiac muscle cell contributing to the regulation of its contraction. This typically occurs via modulation of the activity or expression of voltage-gated ion channels. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
membrane depolarization during atrial cardiac muscle cell action potentialbiological processThe process in which atrial cardiac muscle cell membrane potential changes in the depolarizing direction from the negative resting potential towards the positive membrane potential that will be the peak of the action potential. [GOC:dph, GOC:mtg_cardiac_conduct_nov11, GOC:tb]
calcium ion import across plasma membranebiological processThe directed movement of calcium ions from outside of a cell, across the plasma membrane and into the cytosol. [GOC:dos]