Proteins > muscarinic acetylcholine receptor M1
Page last updated: 2024-08-07 15:20:30

muscarinic acetylcholine receptor M1

[no definition available]

Synonyms

Research

Bioassay Publications (0)

TimeframeStudies on this Protein(%)All Drugs %
pre-19900 (0)18.7374
1990's0 (0)18.2507
2000's0 (0)29.6817
2010's0 (0)24.3611
2020's0 (0)2.80

Compounds (469)

Drugs with Potency Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
betaine aldehydeRattus norvegicus (Norway rat)Potency25.118910
DL-CanavanineRattus norvegicus (Norway rat)Potency7.943310
aminooxyacetic acidRattus norvegicus (Norway rat)Potency2.238710
cholineRattus norvegicus (Norway rat)Potency17.782810
1-aminocyclopropane-1-carboxylic acidRattus norvegicus (Norway rat)Potency28.183810
3,4-dihydroxyphenylacetic acidRattus norvegicus (Norway rat)Potency5.623410
diacetylRattus norvegicus (Norway rat)Potency0.025110
hydroquinoneRattus norvegicus (Norway rat)Potency19.952610
hydroxylamineRattus norvegicus (Norway rat)Potency0.028210
melatoninRattus norvegicus (Norway rat)Potency0.063110
spermidineRattus norvegicus (Norway rat)Potency8.912510
spermineRattus norvegicus (Norway rat)Potency0.891310
dimethylphenylpiperazinium iodideRattus norvegicus (Norway rat)Potency14.125420
1,10-diaminodecaneRattus norvegicus (Norway rat)Potency5.623410
1,3-diethyl-8-phenylxanthineRattus norvegicus (Norway rat)Potency0.446710
1,3-dipropyl-8-cyclopentylxanthineRattus norvegicus (Norway rat)Potency22.387210
1-(1-naphthyl)piperazineRattus norvegicus (Norway rat)Potency17.015720
1-(3-chlorophenyl)biguanideRattus norvegicus (Norway rat)Potency1.000010
1-(3-chlorophenyl)piperazineRattus norvegicus (Norway rat)Potency17.900820
1-(2-trifluoromethylphenyl)imidazoleRattus norvegicus (Norway rat)Potency0.031610
1-aminocyclohexanecarboxylic acidRattus norvegicus (Norway rat)Potency0.177810
1-aminobenzotriazoleRattus norvegicus (Norway rat)Potency0.031610
n-(3-(aminomethyl)benzyl)acetamidineRattus norvegicus (Norway rat)Potency2.511910
1h-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-oneRattus norvegicus (Norway rat)Potency0.035510
3-bromo-7-nitroindazoleRattus norvegicus (Norway rat)Potency18.854120
3-hydroxybenzylhydrazineRattus norvegicus (Norway rat)Potency17.772220
3-methoxytyramineRattus norvegicus (Norway rat)Potency0.031610
3-nitropropionic acidRattus norvegicus (Norway rat)Potency0.063110
cgp 52411Rattus norvegicus (Norway rat)Potency0.089110
4-(2-aminoethyl)benzenesulfonylfluorideRattus norvegicus (Norway rat)Potency22.387210
4-amino-1,8-naphthalimideRattus norvegicus (Norway rat)Potency15.848910
4-aminobenzamidineRattus norvegicus (Norway rat)Potency11.201520
4-diphenylacetoxy-1,1-dimethylpiperidiniumRattus norvegicus (Norway rat)Potency0.013520
homovanillic acidRattus norvegicus (Norway rat)Potency0.017810
4-hydroxybenzoic acid hydrazideRattus norvegicus (Norway rat)Potency31.622810
3-hydroxy-4-methoxyphenethylamineRattus norvegicus (Norway rat)Potency28.183810
4-phenyl-3-furoxancarbonitrileRattus norvegicus (Norway rat)Potency1.312020
5,5-dimethyl-1-pyrroline-1-oxideRattus norvegicus (Norway rat)Potency11.220210
phenytoinRattus norvegicus (Norway rat)Potency5.706220
5,7-dichlorokynurenic acidRattus norvegicus (Norway rat)Potency7.930020
5-dimethylamilorideRattus norvegicus (Norway rat)Potency5.623410
5-(n,n-hexamethylene)amilorideRattus norvegicus (Norway rat)Potency17.782810
ethylisopropylamilorideRattus norvegicus (Norway rat)Potency7.943310
5-carboxamidotryptamineRattus norvegicus (Norway rat)Potency19.952610
6-chloromelatoninRattus norvegicus (Norway rat)Potency4.457620
7-chlorokynurenic acidRattus norvegicus (Norway rat)Potency15.848910
7-nitroindazoleRattus norvegicus (Norway rat)Potency0.100010
8-(4-sulfophenyl)theophyllineRattus norvegicus (Norway rat)Potency0.089110
8-cyclopentyl-1,3-dimethylxanthineRattus norvegicus (Norway rat)Potency28.183810
8-phenyltheophyllineRattus norvegicus (Norway rat)Potency0.070810
tacrineRattus norvegicus (Norway rat)Potency13.891420
aa 861Rattus norvegicus (Norway rat)Potency17.782810
acetohexamideRattus norvegicus (Norway rat)Potency14.125410
beta-aminoethyl isothioureaRattus norvegicus (Norway rat)Potency0.028210
rtki cpdRattus norvegicus (Norway rat)Potency15.954120
tyrphostin 25Rattus norvegicus (Norway rat)Potency3.978020
altretamineRattus norvegicus (Norway rat)Potency2.818410
amifostine anhydrousRattus norvegicus (Norway rat)Potency0.011210
amiodaroneRattus norvegicus (Norway rat)Potency17.782810
amitriptylineRattus norvegicus (Norway rat)Potency0.174920
amoxapineRattus norvegicus (Norway rat)Potency5.962220
amsacrineRattus norvegicus (Norway rat)Potency8.154820
apraclonidineRattus norvegicus (Norway rat)Potency28.183810
arcaineRattus norvegicus (Norway rat)Potency13.891420
aspirinRattus norvegicus (Norway rat)Potency2.238710
azathioprineRattus norvegicus (Norway rat)Potency10.000010
azepexoleRattus norvegicus (Norway rat)Potency17.585520
bml 190Rattus norvegicus (Norway rat)Potency17.782810
bmy 7378Rattus norvegicus (Norway rat)Potency13.357420
3-(1-methyl-4-piperidinyl)-1H-indol-5-olRattus norvegicus (Norway rat)Potency16.815820
bu 224Rattus norvegicus (Norway rat)Potency24.702820
buspironeRattus norvegicus (Norway rat)Potency20.085020
caffeineRattus norvegicus (Norway rat)Potency0.035510
carisoprodolRattus norvegicus (Norway rat)Potency0.100010
carmustineRattus norvegicus (Norway rat)Potency28.183810
chelerythrineRattus norvegicus (Norway rat)Potency35.481310
chlorambucilRattus norvegicus (Norway rat)Potency35.481320
chlorothiazideRattus norvegicus (Norway rat)Potency24.068220
chlorpromazineRattus norvegicus (Norway rat)Potency1.073620
cilostamideRattus norvegicus (Norway rat)Potency17.782810
cimetidineRattus norvegicus (Norway rat)Potency0.089110
cirazolineRattus norvegicus (Norway rat)Potency12.924420
clemizoleRattus norvegicus (Norway rat)Potency6.309610
clofibrateRattus norvegicus (Norway rat)Potency0.006310
clomipramineRattus norvegicus (Norway rat)Potency0.756320
clonidineRattus norvegicus (Norway rat)Potency22.535820
clotrimazoleRattus norvegicus (Norway rat)Potency10.602520
cyclobenzaprineRattus norvegicus (Norway rat)Potency0.071920
cyproheptadineRattus norvegicus (Norway rat)Potency0.027020
cystamineRattus norvegicus (Norway rat)Potency0.035510
decamethoniumRattus norvegicus (Norway rat)Potency12.380720
dequaliniumRattus norvegicus (Norway rat)Potency2.008520
desipramineRattus norvegicus (Norway rat)Potency1.567320
nonivamideRattus norvegicus (Norway rat)Potency1.584910
dicyclomineRattus norvegicus (Norway rat)Potency0.073820
diphenhydramineRattus norvegicus (Norway rat)Potency1.355720
diphenyleneiodoniumRattus norvegicus (Norway rat)Potency17.782810
n,n-di-n-propyldopamineRattus norvegicus (Norway rat)Potency0.501210
dipyridamoleRattus norvegicus (Norway rat)Potency15.848910
disulfiramRattus norvegicus (Norway rat)Potency12.589310
2,3-dimethoxy-1,4-naphthoquinoneRattus norvegicus (Norway rat)Potency1.420420
domperidoneRattus norvegicus (Norway rat)Potency13.357420
dsp 4Rattus norvegicus (Norway rat)Potency1.619420
edrophoniumRattus norvegicus (Norway rat)Potency22.983320
ellipticineRattus norvegicus (Norway rat)Potency25.118910
etazolateRattus norvegicus (Norway rat)Potency7.943310
s-ethyl n-(4-(trifluoromethyl)phenyl)isothioureaRattus norvegicus (Norway rat)Potency21.450920
felbamateRattus norvegicus (Norway rat)Potency0.316210
fenofibrateRattus norvegicus (Norway rat)Potency0.063110
fenspirideRattus norvegicus (Norway rat)Potency14.005320
fluphenazineRattus norvegicus (Norway rat)Potency7.511420
flumazenilRattus norvegicus (Norway rat)Potency2.818410
fluspirileneRattus norvegicus (Norway rat)Potency13.534620
flutamideRattus norvegicus (Norway rat)Potency6.694620
fpl 64176Rattus norvegicus (Norway rat)Potency0.010010
furafyllineRattus norvegicus (Norway rat)Potency0.007110
fusaric acidRattus norvegicus (Norway rat)Potency0.141310
gabapentinRattus norvegicus (Norway rat)Potency28.183810
gallamine triethiodideRattus norvegicus (Norway rat)Potency21.450920
vanoxerineRattus norvegicus (Norway rat)Potency4.764120
gbr 12935Rattus norvegicus (Norway rat)Potency4.901920
glyburideRattus norvegicus (Norway rat)Potency22.387210
guanfacineRattus norvegicus (Norway rat)Potency0.012610
gyki 52466Rattus norvegicus (Norway rat)Potency0.022410
haloperidolRattus norvegicus (Norway rat)Potency10.217520
hexamethoniumRattus norvegicus (Norway rat)Potency0.008910
hydralazineRattus norvegicus (Norway rat)Potency0.028210
lidocaineRattus norvegicus (Norway rat)Potency21.169920
imipramineRattus norvegicus (Norway rat)Potency0.677420
indirubin-3'-monoximeRattus norvegicus (Norway rat)Potency0.112210
iodoacetamideRattus norvegicus (Norway rat)Potency3.162310
4-piperidinecarboxylic acidRattus norvegicus (Norway rat)Potency0.028210
jl 18Rattus norvegicus (Norway rat)Potency0.057420
nsc 664704Rattus norvegicus (Norway rat)Potency7.079510
ketotifenRattus norvegicus (Norway rat)Potency0.588920
kynurenic acidRattus norvegicus (Norway rat)Potency0.017810
lamotrigineRattus norvegicus (Norway rat)Potency2.511910
lansoprazoleRattus norvegicus (Norway rat)Potency0.056210
beta-lapachoneRattus norvegicus (Norway rat)Potency11.519020
leflunomideRattus norvegicus (Norway rat)Potency17.015720
qx-314Rattus norvegicus (Norway rat)Potency14.219120
loperamideRattus norvegicus (Norway rat)Potency17.900820
loratadineRattus norvegicus (Norway rat)Potency10.605820
maprotilineRattus norvegicus (Norway rat)Potency3.352820
methapyrileneRattus norvegicus (Norway rat)Potency12.062720
methoctramineRattus norvegicus (Norway rat)Potency2.219720
metoclopramideRattus norvegicus (Norway rat)Potency0.035510
milrinoneRattus norvegicus (Norway rat)Potency15.848910
mitotaneRattus norvegicus (Norway rat)Potency14.125410
mitoxantroneRattus norvegicus (Norway rat)Potency11.397420
ml 9Rattus norvegicus (Norway rat)Potency0.017810
moxisylyteRattus norvegicus (Norway rat)Potency10.266320
muscimolRattus norvegicus (Norway rat)Potency28.183810
acecainideRattus norvegicus (Norway rat)Potency6.309610
n-bromoacetamideRattus norvegicus (Norway rat)Potency31.622810
clorgylineRattus norvegicus (Norway rat)Potency15.954120
nan 190Rattus norvegicus (Norway rat)Potency6.783420
neostigmineRattus norvegicus (Norway rat)Potency6.783420
niclosamideRattus norvegicus (Norway rat)Potency3.540620
nifedipineRattus norvegicus (Norway rat)Potency15.848910
nilutamideRattus norvegicus (Norway rat)Potency6.295420
no 711Rattus norvegicus (Norway rat)Potency25.118910
nortriptylineRattus norvegicus (Norway rat)Potency0.968420
oxatomideRattus norvegicus (Norway rat)Potency10.430420
oxolinic acidRattus norvegicus (Norway rat)Potency0.017810
oxotremorine mRattus norvegicus (Norway rat)Potency0.010010
oxymetazolineRattus norvegicus (Norway rat)Potency9.106320
4-iodoclonidineRattus norvegicus (Norway rat)Potency15.848910
palmidrolRattus norvegicus (Norway rat)Potency0.089110
papaverineRattus norvegicus (Norway rat)Potency3.999820
pd 169316Rattus norvegicus (Norway rat)Potency17.782810
pd 98059Rattus norvegicus (Norway rat)Potency3.162310
pentoxifyllineRattus norvegicus (Norway rat)Potency0.070810
perphenazineRattus norvegicus (Norway rat)Potency15.586420
moxonidineRattus norvegicus (Norway rat)Potency17.782810
pindololRattus norvegicus (Norway rat)Potency0.031610
piperidine-4-sulfonic acidRattus norvegicus (Norway rat)Potency0.100010
pirenperoneRattus norvegicus (Norway rat)Potency11.519020
pirenzepineRattus norvegicus (Norway rat)Potency0.113020
piribedilRattus norvegicus (Norway rat)Potency11.519020
praziquantelRattus norvegicus (Norway rat)Potency28.370820
proadifenRattus norvegicus (Norway rat)Potency5.833420
procainamideRattus norvegicus (Norway rat)Potency6.309610
procaineRattus norvegicus (Norway rat)Potency15.954120
prochlorperazineRattus norvegicus (Norway rat)Potency5.623420
promazineRattus norvegicus (Norway rat)Potency1.680420
propanthelineRattus norvegicus (Norway rat)Potency0.006120
propofolRattus norvegicus (Norway rat)Potency17.782810
protriptylineRattus norvegicus (Norway rat)Potency0.278320
pyridostigmineRattus norvegicus (Norway rat)Potency0.063110
pyrilamineRattus norvegicus (Norway rat)Potency13.534620
quipazineRattus norvegicus (Norway rat)Potency15.371220
6-nitroquipazineRattus norvegicus (Norway rat)Potency7.943310
n-methylquipazineRattus norvegicus (Norway rat)Potency19.952620
qx-222Rattus norvegicus (Norway rat)Potency0.354810
raloxifeneRattus norvegicus (Norway rat)Potency15.848920
risperidoneRattus norvegicus (Norway rat)Potency15.186120
ritanserinRattus norvegicus (Norway rat)Potency9.505620
ro 41-1049Rattus norvegicus (Norway rat)Potency6.309610
ropiniroleRattus norvegicus (Norway rat)Potency15.954120
sanguinarineRattus norvegicus (Norway rat)Potency6.365320
sb 206553Rattus norvegicus (Norway rat)Potency12.589310
sdz 205-557Rattus norvegicus (Norway rat)Potency17.782810
carbamylhydrazineRattus norvegicus (Norway rat)Potency13.347720
linsidomineRattus norvegicus (Norway rat)Potency0.079410
sk&f 91488Rattus norvegicus (Norway rat)Potency0.005610
sk&f 97541Rattus norvegicus (Norway rat)Potency7.943310
sobuzoxaneRattus norvegicus (Norway rat)Potency0.079410
spiperoneRattus norvegicus (Norway rat)Potency6.774020
sulfaphenazoleRattus norvegicus (Norway rat)Potency0.022410
1,4-bis(2-(3,5-dichloropyridyloxy))benzeneRattus norvegicus (Norway rat)Potency0.281810
telenzepineRattus norvegicus (Norway rat)Potency0.029920
terfenadineRattus norvegicus (Norway rat)Potency9.581820
tetracaineRattus norvegicus (Norway rat)Potency21.154620
tetraethylammoniumRattus norvegicus (Norway rat)Potency3.162310
tetraisopropylpyrophosphamideRattus norvegicus (Norway rat)Potency0.251210
theobromineRattus norvegicus (Norway rat)Potency0.011210
tiaprideRattus norvegicus (Norway rat)Potency5.177420
8-(n,n-diethylamino)octyl-3,4,5-trimethoxybenzoateRattus norvegicus (Norway rat)Potency2.818420
tolazamideRattus norvegicus (Norway rat)Potency0.011210
tolbutamideRattus norvegicus (Norway rat)Potency0.028210
ici 136,753Rattus norvegicus (Norway rat)Potency22.387210
trazodoneRattus norvegicus (Norway rat)Potency22.387210
trequinsinRattus norvegicus (Norway rat)Potency23.735820
triamtereneRattus norvegicus (Norway rat)Potency0.002210
trifluoperazineRattus norvegicus (Norway rat)Potency10.000020
trifluperidolRattus norvegicus (Norway rat)Potency18.256320
triflupromazineRattus norvegicus (Norway rat)Potency0.579220
trimethoprimRattus norvegicus (Norway rat)Potency14.125410
tyramineRattus norvegicus (Norway rat)Potency0.050110
tyrphostin a9Rattus norvegicus (Norway rat)Potency0.716320
u 101958Rattus norvegicus (Norway rat)Potency15.848920
u 99194Rattus norvegicus (Norway rat)Potency1.885420
urapidilRattus norvegicus (Norway rat)Potency14.987220
5-methylurapidilRattus norvegicus (Norway rat)Potency24.702820
w 7Rattus norvegicus (Norway rat)Potency10.472620
n-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-n-(2-pyridinyl)cyclohexanecarboxamideRattus norvegicus (Norway rat)Potency19.952610
8-(4-((2-aminoethyl)aminocarbonylmethyloxy)phenyl)-1,3-dipropylxanthineRattus norvegicus (Norway rat)Potency19.091920
xylazineRattus norvegicus (Norway rat)Potency13.347720
xylometazolineRattus norvegicus (Norway rat)Potency7.811720
3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazoleRattus norvegicus (Norway rat)Potency28.183810
n,n-bis(3,4-dimethoxyphenethyl)-n-methylamineRattus norvegicus (Norway rat)Potency15.954120
zardaverineRattus norvegicus (Norway rat)Potency89.125110
cortisone acetateRattus norvegicus (Norway rat)Potency17.559420
reserpineRattus norvegicus (Norway rat)Potency7.268020
serineRattus norvegicus (Norway rat)Potency9.981920
bromodeoxyuridineRattus norvegicus (Norway rat)Potency14.125410
levodopaRattus norvegicus (Norway rat)Potency0.070810
bretylium tosylateRattus norvegicus (Norway rat)Potency11.294720
colchicineRattus norvegicus (Norway rat)Potency0.891310
cycloserineRattus norvegicus (Norway rat)Potency28.183810
arginineRattus norvegicus (Norway rat)Potency0.398110
synephrineRattus norvegicus (Norway rat)Potency1.412510
suramin sodiumRattus norvegicus (Norway rat)Potency1.584910
chelidamic acidRattus norvegicus (Norway rat)Potency0.031610
muscarineRattus norvegicus (Norway rat)Potency2.511910
azacitidineRattus norvegicus (Norway rat)Potency1.122010
acetylcysteineRattus norvegicus (Norway rat)Potency12.589310
pimozideRattus norvegicus (Norway rat)Potency12.380720
stavudineRattus norvegicus (Norway rat)Potency2.818410
tranylcypromineRattus norvegicus (Norway rat)Potency17.782810
dexpropranololRattus norvegicus (Norway rat)Potency0.364210
n-methylaspartateRattus norvegicus (Norway rat)Potency0.014110
d-glutamateRattus norvegicus (Norway rat)Potency4.466810
levodopa methyl esterRattus norvegicus (Norway rat)Potency4.466810
propionylpromazineRattus norvegicus (Norway rat)Potency0.905320
clemastineRattus norvegicus (Norway rat)Potency0.169020
metergolineRattus norvegicus (Norway rat)Potency17.900820
(3R)-6,7-dimethoxy-3-[(5R)-4-methoxy-6-methyl-7,8-dihydro-5H-[1,3]dioxolo[4,5-g]isoquinolin-5-yl]-3H-isobenzofuran-1-oneRattus norvegicus (Norway rat)Potency0.125910
timololRattus norvegicus (Norway rat)Potency5.011910
ribavirinRattus norvegicus (Norway rat)Potency0.050110
nimustineRattus norvegicus (Norway rat)Potency22.387210
quisqualic acidRattus norvegicus (Norway rat)Potency0.017810
enoximoneRattus norvegicus (Norway rat)Potency12.589310
quinpiroleRattus norvegicus (Norway rat)Potency2.238710
(S)-nomifensineRattus norvegicus (Norway rat)Potency0.070810
salmeterol xinafoateRattus norvegicus (Norway rat)Potency11.220210
quineloraneRattus norvegicus (Norway rat)Potency15.848910
mibefradilRattus norvegicus (Norway rat)Potency26.632020
eliprodilRattus norvegicus (Norway rat)Potency4.170720
aptiganelRattus norvegicus (Norway rat)Potency9.106320
paroxetine hydrochlorideRattus norvegicus (Norway rat)Potency2.620020
u 37883aRattus norvegicus (Norway rat)Potency15.954120
rutecarpineRattus norvegicus (Norway rat)Potency17.782810
dexamisoleRattus norvegicus (Norway rat)Potency11.057620
masoprocolRattus norvegicus (Norway rat)Potency0.028210
loxapine succinateRattus norvegicus (Norway rat)Potency1.722020
opipramol hydrochlorideRattus norvegicus (Norway rat)Potency3.681320
carbobenzoxyvalylphenylalanine aldehydeRattus norvegicus (Norway rat)Potency0.014110
tosyllysine chloromethyl ketoneRattus norvegicus (Norway rat)Potency17.782810
5-(n-methyl-n-isobutyl)amilorideRattus norvegicus (Norway rat)Potency0.039810
amperozideRattus norvegicus (Norway rat)Potency17.782820
carbetapentane citrateRattus norvegicus (Norway rat)Potency0.197020
phentolamine mesylateRattus norvegicus (Norway rat)Potency4.466810
sk&f 95282Rattus norvegicus (Norway rat)Potency11.519020
lekoptinRattus norvegicus (Norway rat)Potency14.219120
corynanthineRattus norvegicus (Norway rat)Potency19.541320
imidazoleacetic acidRattus norvegicus (Norway rat)Potency0.063110
3-aminopropylphosphonic acidRattus norvegicus (Norway rat)Potency10.000010
zpckRattus norvegicus (Norway rat)Potency4.466810
n-acetyldopamineRattus norvegicus (Norway rat)Potency17.782810
alphaxaloneRattus norvegicus (Norway rat)Potency22.016420
chlorethylclonidineRattus norvegicus (Norway rat)Potency12.672820
methyl 6,7-dimethoxy-4-ethyl-beta-carboline-3-carboxylateRattus norvegicus (Norway rat)Potency9.505620
vinpocetineRattus norvegicus (Norway rat)Potency17.782810
gr 127935Rattus norvegicus (Norway rat)Potency22.874120
benzamilRattus norvegicus (Norway rat)Potency14.987220
sch 28080Rattus norvegicus (Norway rat)Potency19.952610
3',4'-dichlorobenzamilRattus norvegicus (Norway rat)Potency17.782810
1-(carboxymethylthio)tetradecaneRattus norvegicus (Norway rat)Potency0.125910
olprinoneRattus norvegicus (Norway rat)Potency0.028210
gr 113808Rattus norvegicus (Norway rat)Potency25.118910
sb 204070aRattus norvegicus (Norway rat)Potency9.874420
1-(2-(4-aminophenyl)ethyl)-4-(3-trifluoromethylphenyl)piperazineRattus norvegicus (Norway rat)Potency12.672820
uh 301Rattus norvegicus (Norway rat)Potency11.782620
1-(1-(2-benzo(b)thienyl)cyclohexyl)piperidineRattus norvegicus (Norway rat)Potency7.943310
n(omega)-hydroxyarginineRattus norvegicus (Norway rat)Potency0.050110
sk&f 86466Rattus norvegicus (Norway rat)Potency20.085020
l 687384Rattus norvegicus (Norway rat)Potency11.294720
indatralineRattus norvegicus (Norway rat)Potency2.238710
pre 084Rattus norvegicus (Norway rat)Potency8.060420
n-(2-chloroethyl)-4-piperidinyl diphenylacetateRattus norvegicus (Norway rat)Potency0.337220
sr 57227aRattus norvegicus (Norway rat)Potency17.782820
n,n-di-n-hexyl-2-(4-fluorophenyl)indole-3-acetamideRattus norvegicus (Norway rat)Potency0.089110
4-(benzodioxan-5-yl)-1-(indan-2-yl)piperazineRattus norvegicus (Norway rat)Potency5.091020
8-cyclopentyl-3-(3-((4-(fluorosulfonyl)benzoyl)oxy)propyl)-1-propylxanthineRattus norvegicus (Norway rat)Potency16.597820
l 741626Rattus norvegicus (Norway rat)Potency11.904820
d-apvRattus norvegicus (Norway rat)Potency22.387210
3,4-dichloro-n-methyl-n-(2-(1-pyrrolidinyl)cyclohexyl)-benzeneacetamide, (trans)-(+-)-isomerRattus norvegicus (Norway rat)Potency13.891420
escitalopramRattus norvegicus (Norway rat)Potency8.154820
n,n-dipropylcarboxamidotryptamineRattus norvegicus (Norway rat)Potency17.900820
alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acidRattus norvegicus (Norway rat)Potency28.183810
n-phthaloylglutamic acidRattus norvegicus (Norway rat)Potency0.025110
1,3-dipropyl-7-methylxanthineRattus norvegicus (Norway rat)Potency19.952610
gabaculineRattus norvegicus (Norway rat)Potency5.011910
esatenololRattus norvegicus (Norway rat)Potency5.093620
sb 216763Rattus norvegicus (Norway rat)Potency14.125410
dizocilpineRattus norvegicus (Norway rat)Potency0.199510
succinylprolineRattus norvegicus (Norway rat)Potency0.022410
ent-diltiazemRattus norvegicus (Norway rat)Potency7.943310
preclamolRattus norvegicus (Norway rat)Potency18.010920
dexefaroxanRattus norvegicus (Norway rat)Potency15.848910
cortisoneRattus norvegicus (Norway rat)Potency16.271020
nsc 95397Rattus norvegicus (Norway rat)Potency10.000010
lithium chlorideRattus norvegicus (Norway rat)Potency0.020010
canavanineRattus norvegicus (Norway rat)Potency0.031610
5-hydroxytryptophanRattus norvegicus (Norway rat)Potency4.466810
cortodoxoneRattus norvegicus (Norway rat)Potency5.962220
hydrastine hydrochloride, (s-(r*,s*))-isomerRattus norvegicus (Norway rat)Potency25.118910
sb 228357Rattus norvegicus (Norway rat)Potency17.782810
5,11-diethyl-5,6,11,12-tetrahydrochrysene-2,8-diolRattus norvegicus (Norway rat)Potency11.294720
6-bromoindirubin-3'-oximeRattus norvegicus (Norway rat)Potency7.112720
ketoconazoleRattus norvegicus (Norway rat)Potency10.750920
chloroquine diphosphateRattus norvegicus (Norway rat)Potency6.477620
gw9662Rattus norvegicus (Norway rat)Potency0.079410
tropisetronRattus norvegicus (Norway rat)Potency6.205020
5H-quinolino[8,7-c][1,2]benzothiazine 6,6-dioxideRattus norvegicus (Norway rat)Potency1.000010
vesamicolRattus norvegicus (Norway rat)Potency14.125410
doxepin hydrochlorideRattus norvegicus (Norway rat)Potency0.516320
ag-213Rattus norvegicus (Norway rat)Potency14.125410
bemesetronRattus norvegicus (Norway rat)Potency3.571720
sch-202676Rattus norvegicus (Norway rat)Potency8.800620
4-bromotetramisole, (s)-isomerRattus norvegicus (Norway rat)Potency14.219120
dexchlorpheniramineRattus norvegicus (Norway rat)Potency6.484920
(2'-(4-aminophenyl)-(2,5'-bi-1h-benzimidazol)-5-amine)Rattus norvegicus (Norway rat)Potency4.466810
thiothixeneRattus norvegicus (Norway rat)Potency14.125410
6-chloro-4-phenyl-3-(1-phenyl-5-tetrazolyl)quinolineRattus norvegicus (Norway rat)Potency25.118910
cinnarizineRattus norvegicus (Norway rat)Potency3.395120
fluoxetineRattus norvegicus (Norway rat)Potency11.281520
d-ap7Rattus norvegicus (Norway rat)Potency0.017810
5,6,7,8-tetrafluoro-2-(2,3,4,5,6-pentafluorophenyl)-4h-1-benzopyran-4-oneRattus norvegicus (Norway rat)Potency5.011910
3-(n,n-dimethylsulfonamido)-4-methyl-nitrobenzeneRattus norvegicus (Norway rat)Potency0.011210
ranitidineRattus norvegicus (Norway rat)Potency15.848910
6-methyl-2-(phenylethynyl)pyridineRattus norvegicus (Norway rat)Potency13.948020
thioperamideRattus norvegicus (Norway rat)Potency17.039020
sk&f 10047Rattus norvegicus (Norway rat)Potency16.385020
u-50488Rattus norvegicus (Norway rat)Potency15.848920
bp 897Rattus norvegicus (Norway rat)Potency17.039020
benzatropine methanesulfonateRattus norvegicus (Norway rat)Potency0.005820
sb 203186Rattus norvegicus (Norway rat)Potency16.815820
n-(1-methyl-5-indolyl)-n'-(3-methyl-5-isothiazolyl)ureaRattus norvegicus (Norway rat)Potency15.848910
sb-224289Rattus norvegicus (Norway rat)Potency14.987220
cgp 13501Rattus norvegicus (Norway rat)Potency35.481310
n-(2-(4-(4-chlorophenyl)piperazin-1-yl)ethyl)-3-methoxybenzamideRattus norvegicus (Norway rat)Potency11.220220
pd 168,077Rattus norvegicus (Norway rat)Potency0.007910
mrs 1523Rattus norvegicus (Norway rat)Potency0.017810
sb 415286Rattus norvegicus (Norway rat)Potency17.782810
dm 235Rattus norvegicus (Norway rat)Potency25.118910
LY-310762Rattus norvegicus (Norway rat)Potency17.631620
sc 560Rattus norvegicus (Norway rat)Potency11.703120
sc-19220Rattus norvegicus (Norway rat)Potency5.050020
le 300Rattus norvegicus (Norway rat)Potency16.815820
thiorphanRattus norvegicus (Norway rat)Potency11.220210
ly 367265Rattus norvegicus (Norway rat)Potency14.987220
1,3,5-tris(4-hydroxyphenyl)-4-propyl-1h-pyrazoleRattus norvegicus (Norway rat)Potency17.782810
sib 1757Rattus norvegicus (Norway rat)Potency4.466810
ac 915Rattus norvegicus (Norway rat)Potency17.039020
quercetinRattus norvegicus (Norway rat)Potency11.557420
daphnetinRattus norvegicus (Norway rat)Potency22.387210
bisoprolol fumarateRattus norvegicus (Norway rat)Potency0.015810
harmanRattus norvegicus (Norway rat)Potency25.118910
morinRattus norvegicus (Norway rat)Potency0.020010
tranilastRattus norvegicus (Norway rat)Potency0.125910
ic 261Rattus norvegicus (Norway rat)Potency4.901920
su 9516Rattus norvegicus (Norway rat)Potency3.162310
4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acidRattus norvegicus (Norway rat)Potency0.089110
(alpha-carboxycyclopropyl)glycine, (1r-(1alpha(s*),2alpha))-isomerRattus norvegicus (Norway rat)Potency0.039810
denopamineRattus norvegicus (Norway rat)Potency7.996020
k 185Rattus norvegicus (Norway rat)Potency7.943310
l 745870Rattus norvegicus (Norway rat)Potency17.782810
ml 10302Rattus norvegicus (Norway rat)Potency16.531120
pd 128907Rattus norvegicus (Norway rat)Potency2.379020
su 6656Rattus norvegicus (Norway rat)Potency7.126420
ro 4-6790Rattus norvegicus (Norway rat)Potency25.118910
ag 538Rattus norvegicus (Norway rat)Potency5.011910
tyrphostin ag 555Rattus norvegicus (Norway rat)Potency11.220210
tyrphostin ag-494Rattus norvegicus (Norway rat)Potency19.952610
ag-490Rattus norvegicus (Norway rat)Potency15.848910
molsidomineRattus norvegicus (Norway rat)Potency7.943310
dextromethorphanRattus norvegicus (Norway rat)Potency10.882020
zimeldineRattus norvegicus (Norway rat)Potency17.039020
cisplatinRattus norvegicus (Norway rat)Potency0.141310
s-trans,trans-farnesylthiosalicylic acidRattus norvegicus (Norway rat)Potency0.044710
sulindac sulfoneRattus norvegicus (Norway rat)Potency0.089110
gw-5074Rattus norvegicus (Norway rat)Potency14.550020
nf023Rattus norvegicus (Norway rat)Potency3.981110
nf 449Rattus norvegicus (Norway rat)Potency0.020010
gw 1929Rattus norvegicus (Norway rat)Potency4.466810
n(4)-chloroacetylcytosine arabinosideRattus norvegicus (Norway rat)Potency28.183810
n-(3-(cyclohexylidene-(1h-imidazol-4-ylmethyl))phenyl)ethanesulfonamideRattus norvegicus (Norway rat)Potency5.623410
n-(4-amino-2-chlorophenyl)phthalimideRattus norvegicus (Norway rat)Potency0.008910
cgp 12177aRattus norvegicus (Norway rat)Potency3.548110
b 43Rattus norvegicus (Norway rat)Potency7.079510
(8R)-7-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-2,13,14-triolRattus norvegicus (Norway rat)Potency3.991620
(8R)-7-propyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-2,13,14-triolRattus norvegicus (Norway rat)Potency7.065820
dilazep(2+)Rattus norvegicus (Norway rat)Potency2.391520
erythro-dihydrosphingosineRattus norvegicus (Norway rat)Potency8.912510
3-(6-chloro-3-pyridazinyl)-3,8-diazabicyclo(3.2.1)octaneRattus norvegicus (Norway rat)Potency15.954120
2-(3,3-diphenylpropylamino)acetamideRattus norvegicus (Norway rat)Potency7.079510
4-(2-(phenylsulfonylamino)ethylthio)-2,6-difluorophenoxyacetamideRattus norvegicus (Norway rat)Potency6.383520
gr 103545Rattus norvegicus (Norway rat)Potency17.782810
gw2974Rattus norvegicus (Norway rat)Potency21.421520
8-hydroxy-2-(di-n-propylamino)tetralin, (r)-isomerRattus norvegicus (Norway rat)Potency5.530320
7-hydroxy-2-n,n-dipropylaminotetralin, (r)-isomerRattus norvegicus (Norway rat)Potency3.571720
l 750667Rattus norvegicus (Norway rat)Potency14.987220
l 162313Rattus norvegicus (Norway rat)Potency0.007110
l-165041Rattus norvegicus (Norway rat)Potency0.125910
4-(2' methoxyphenyl)-1-(2'-(n-(2''-pyridinyl)-4-fluorobenzamido)ethyl)piperazineRattus norvegicus (Norway rat)Potency25.118910
mrs 1754Rattus norvegicus (Norway rat)Potency0.028210
pd 404182Rattus norvegicus (Norway rat)Potency0.035510
5-(4-phenylbutoxy)psoralenRattus norvegicus (Norway rat)Potency9.053220
sb 222200Rattus norvegicus (Norway rat)Potency5.011910
sb 218795Rattus norvegicus (Norway rat)Potency0.079410
molindone hydrochlorideRattus norvegicus (Norway rat)Potency28.183810
valproate sodiumRattus norvegicus (Norway rat)Potency7.943310
u 63557aRattus norvegicus (Norway rat)Potency0.141310
phenytoin sodiumRattus norvegicus (Norway rat)Potency17.900820
piroxicamRattus norvegicus (Norway rat)Potency3.162310
lfm a13Rattus norvegicus (Norway rat)Potency0.039810
sepiapterinRattus norvegicus (Norway rat)Potency8.912510
clozapineRattus norvegicus (Norway rat)Potency0.065820
ag-879Rattus norvegicus (Norway rat)Potency2.006420

Drugs with Activation Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
3-amino-n-(4-methoxybenzyl)-4,6-dimethylthieno(2,3-b)pyridine-2-carboxamideRattus norvegicus (Norway rat)EC500.003310
2-[[1-[(3-fluorophenyl)methyl]-3-indolyl]sulfonyl]-N-(5-methyl-3-isoxazolyl)acetamideRattus norvegicus (Norway rat)EC505.272020
vu0357017Rattus norvegicus (Norway rat)EC500.197510
2-[[1-[(3-chlorophenyl)methyl]-3-indolyl]sulfonyl]-N-(5-methyl-3-isoxazolyl)acetamideRattus norvegicus (Norway rat)EC505.838520
N-(5-methyl-3-isoxazolyl)-2-[[1-[[3-(trifluoromethyl)phenyl]methyl]-3-indolyl]sulfonyl]acetamideRattus norvegicus (Norway rat)EC5030.000010
2-[[1-[(3-bromophenyl)methyl]-3-indolyl]sulfonyl]-N-(5-methyl-3-isoxazolyl)acetamideRattus norvegicus (Norway rat)EC503.790010
ml 137Rattus norvegicus (Norway rat)EC500.845010