dimercaprol has been researched along with Necrosis in 5 studies
Dimercaprol: An anti-gas warfare agent that is effective against Lewisite (dichloro(2-chlorovinyl)arsine) and formerly known as British Anti-Lewisite or BAL. It acts as a chelating agent and is used in the treatment of arsenic, gold, and other heavy metal poisoning.
dimercaprol : A dithiol that is propane-1,2-dithiol in which one of the methyl hydrogens is replaced by a hydroxy group. a chelating agent originally developed during World War II as an experimental antidote against the arsenic-based poison gas Lewisite, it has been used clinically since 1949 for the treatment of poisoning by arsenic, mercury and gold. It can also be used for treatment of poisoning by antimony, bismuth and possibly thallium, and (with sodium calcium edetate) in cases of acute leaad poisoning. Administration is by (painful) intramuscular injection of a suspension of dimercaprol in peanut oil, typically every 4 hours for 2-10 days depending on the toxicity. In the past, dimercaprol was also used for the treatment of Wilson's disease, a severely debilitating genetic disorder in which the body tends to retain copper, with resultant liver and brain injury.
Necrosis: The death of cells in an organ or tissue due to disease, injury or failure of the blood supply.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Gold salts are still a first choice for treatment of rheumatoid arthritis." | 8.78 | [Fatal hepatic necrosis due to a treatment course of rheumatoid arthritis with gold salts]. ( Beyner, F; Buss, W; Ott, H; Van Linthoudt, D, 1991) |
| "The renal tubular necrosis and calcification as well as the mortality induced by mercuric chloride in the rat are readily prevented by prior treatment with well-tolerated amounts of spironolactone." | 7.65 | Mercury poisoning: prevention by spironolactone. ( Selye, H, 1970) |
| "Gold salts are still a first choice for treatment of rheumatoid arthritis." | 4.78 | [Fatal hepatic necrosis due to a treatment course of rheumatoid arthritis with gold salts]. ( Beyner, F; Buss, W; Ott, H; Van Linthoudt, D, 1991) |
| "The renal tubular necrosis and calcification as well as the mortality induced by mercuric chloride in the rat are readily prevented by prior treatment with well-tolerated amounts of spironolactone." | 3.65 | Mercury poisoning: prevention by spironolactone. ( Selye, H, 1970) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (60.00) | 18.7374 |
| 1990's | 1 (20.00) | 18.2507 |
| 2000's | 1 (20.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Soo, YO | 1 |
| Wong, CH | 1 |
| Griffith, JF | 1 |
| Chan, TY | 1 |
| BOHM, C | 1 |
| SINGER, L | 1 |
| HASSELMANN, CM | 1 |
| RICHTER, R | 1 |
| BERGMANN, A | 1 |
| EILLES, W | 1 |
| JOHNE, HO | 1 |
| Van Linthoudt, D | 1 |
| Buss, W | 1 |
| Beyner, F | 1 |
| Ott, H | 1 |
| Selye, H | 1 |
1 review available for dimercaprol and Necrosis
| Article | Year |
|---|---|
[Fatal hepatic necrosis due to a treatment course of rheumatoid arthritis with gold salts].
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Chemical and Drug Induced Liver Injury; Dimercaprol; Go | 1991 |
4 other studies available for dimercaprol and Necrosis
| Article | Year |
|---|---|
Subcutaneous injection of metallic mercury.
Topics: Adult; Arm; Chelating Agents; Dimercaprol; Female; Humans; Injections, Subcutaneous; Mercury; Mercur | 2003 |
[Complications and one fatality, in exsudative spirotrypan dermatitis treated with sulfactin].
Topics: Arsenicals; Arsphenamine; Bone Diseases; Dermatitis; Dimercaprol; Disease; Drug Eruptions; Muscles; | 1954 |
[Experimental and clinical observations on necrosis of muscle following injection of BAL and sulfactin (Homburg), and its relation to the Sanarelli-Shwartzman phenomenon].
Topics: Dimercaprol; Humans; Hypersensitivity; Immune System Diseases; Muscles; Necrosis; Shwartzman Phenome | 1951 |
Mercury poisoning: prevention by spironolactone.
Topics: Acute Kidney Injury; Animals; Chelating Agents; Dimercaprol; Female; Kidney Tubules; Mercury Poisoni | 1970 |