Page last updated: 2024-08-07 16:31:25
Kappa-type opioid receptor
A kappa-type opioid receptor that is encoded in the genome of mouse. [OMA:P33534, PRO:DNx]
Synonyms
K-OR-1;
KOR-1;
MSL-1
Research
Bioassay Publications (33)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 8 (24.24) | 18.7374 |
| 1990's | 11 (33.33) | 18.2507 |
| 2000's | 3 (9.09) | 29.6817 |
| 2010's | 8 (24.24) | 24.3611 |
| 2020's | 3 (9.09) | 2.80 |
Compounds (40)
Drugs with Inhibition Measurements
Drugs with Activation Measurements
Drugs with Other Measurements
Isolation and Pharmacological Characterization of Six Opioidergic Journal of natural products, , 01-22, Volume: 84, Issue:1, 2021
Plant-Derived Cyclotides Modulate κ-Opioid Receptor Signaling.Journal of natural products, , 08-27, Volume: 84, Issue:8, 2021
Novel 6β-acylaminomorphinans with analgesic activity.European journal of medicinal chemistry, , Volume: 69, 2013
Design, synthesis, and structure-activity relationship of novel opioid kappa-agonists.Bioorganic & medicinal chemistry, , Oct-15, Volume: 16, Issue:20, 2008
Structure/activity studies related to 2-(3,4-dichlorophenyl)-N-methyl-N-[2-(1-pyrrolidinyl)-1-substituted- ethyl]acetamides: a novel series of potent and selective kappa-opioid agonists.Journal of medicinal chemistry, , Volume: 34, Issue:11, 1991
Naphtho and benzo analogues of the kappa opioid agonist trans-(+/-)-3,4-dichloro-N-methyl-N-[2-(1-pyrrolidinyl)cyclohexyl] benzeneacetamide.Journal of medicinal chemistry, , Volume: 34, Issue:6, 1991
Arylacetamide-derived fluorescent probes: synthesis, biological evaluation, and direct fluorescent labeling of kappa opioid receptors in mouse microglial cells.Journal of medicinal chemistry, , Apr-12, Volume: 39, Issue:8, 1996
Structure/activity studies related to 2-(3,4-dichlorophenyl)-N-methyl-N-[2-(1-pyrrolidinyl)-1-substituted- ethyl]acetamides: a novel series of potent and selective kappa-opioid agonists.Journal of medicinal chemistry, , Volume: 34, Issue:11, 1991
Synthesis and biological evaluation of 14-alkoxymorphinans. 11. 3-Hydroxycyprodime and analogues: opioid antagonist profile in comparison to cyprodime.Journal of medicinal chemistry, , Aug-04, Volume: 38, Issue:16, 1995
Synthesis and biological evaluation of [125I]- and [123I]-4-iododexetimide, a potent muscarinic cholinergic receptor antagonist.Journal of medicinal chemistry, , Volume: 32, Issue:5, 1989
Access to 7β-analogs of codeine with mixed μ/δ agonist activity via 6,7-α-epoxide opening.Bioorganic & medicinal chemistry letters, , Sep-01, Volume: 23, Issue:17, 2013
Design, synthesis, and structure-activity relationship of novel opioid kappa-agonists.Bioorganic & medicinal chemistry, , Oct-15, Volume: 16, Issue:20, 2008
Selective kappa-opioid agonists: synthesis and structure-activity relationships of piperidines incorporating on oxo-containing acyl group.Journal of medicinal chemistry, , Oct-14, Volume: 37, Issue:21, 1994
Structure/activity studies related to 2-(3,4-dichlorophenyl)-N-methyl-N-[2-(1-pyrrolidinyl)-1-substituted- ethyl]acetamides: a novel series of potent and selective kappa-opioid agonists.Journal of medicinal chemistry, , Volume: 34, Issue:11, 1991
Synthesis and structure-activity relationships of dynorphin A-(1-8) amide analogues.Journal of medicinal chemistry, , Volume: 33, Issue:1, 1990
Synthesis and pharmacology of metabolically stable tert-butyl ethers of morphine and levorphanol.Journal of medicinal chemistry, , Volume: 25, Issue:10, 1982
Synthesis and biological activity of fluoroalkylamine derivatives of narcotic analgesics.Journal of medicinal chemistry, , Volume: 23, Issue:9, 1980
Design, syntheses, and pharmacological characterization of 17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6α-(isoquinoline-3'-carboxamido)morphinan analogues as opioid receptor ligands.Bioorganic & medicinal chemistry, , Apr-15, Volume: 23, Issue:8, 2015
Structure activity relationship studies of 17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6α-(isoquinoline-3'-carboxamido)morphinan (NAQ) analogues as potent opioid receptor ligands: preliminary results on the role of electronic characteristics for affinBioorganic & medicinal chemistry letters, , Sep-15, Volume: 23, Issue:18, 2013
N-Substituted 9beta-methyl-5-(3-hydroxyphenyl)morphans are opioid receptor pure antagonists.Journal of medicinal chemistry, , Oct-08, Volume: 41, Issue:21, 1998
Probes for narcotic receptor mediated phenomena. 18. Epimeric 6 alpha- and 6 beta-iodo-3,14-dihydroxy-17-(cyclopropylmethyl)-4,5 alpha-epoxymorphinans as potential ligands for opioid receptor single photon emission computed tomography: synthesis, evaluatiJournal of medicinal chemistry, , Jul-24, Volume: 35, Issue:15, 1992