Proteins > Estrogen-related receptor gamma
Page last updated: 2024-08-07 13:25:14

Estrogen-related receptor gamma

An estrogen-related receptor gamma that is encoded in the genome of human. [PRO:DNx, UniProtKB:P62508]

Synonyms

ERR gamma-2;
Estrogen receptor-related protein 3;
Nuclear receptor subfamily 3 group B member 3

Research

Bioassay Publications (10)

TimeframeStudies on this Protein(%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's3 (30.00)29.6817
2010's6 (60.00)24.3611
2020's1 (10.00)2.80

Compounds (10)

Drugs with Inhibition Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
bisphenol aHomo sapiens (human)IC500.009022
4-cumylphenolHomo sapiens (human)IC500.013911
4-[1-[4-[2-(dimethylamino)ethoxy]phenyl]-2-phenylbut-1-enyl]phenolHomo sapiens (human)IC500.348544
afimoxifeneHomo sapiens (human)IC500.008423
tamoxifenHomo sapiens (human)IC500.062211
4-hydroxytoremifeneHomo sapiens (human)IC500.010023
gsk 4716Homo sapiens (human)IC502.000011
n'-((1e)-(4-(diethylamino)phenyl)methylene)-4-hydroxybenzohydrazideHomo sapiens (human)IC500.660011
gsk5182Homo sapiens (human)IC500.146467

Drugs with Activation Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
4-[1-[4-[2-(dimethylamino)ethoxy]phenyl]-2-phenylbut-1-enyl]phenolHomo sapiens (human)EC500.015011
diethylstilbestrolHomo sapiens (human)EC500.630022
afimoxifeneHomo sapiens (human)EC500.015011
gsk 4716Homo sapiens (human)EC501.274844
gsk 4716Homo sapiens (human)Kd5.000011
n'-((1e)-(4-(diethylamino)phenyl)methylene)-4-hydroxybenzohydrazideHomo sapiens (human)EC500.130022

Enables

This protein enables 10 target(s):

TargetCategoryDefinition
DNA-binding transcription factor activity, RNA polymerase II-specificmolecular functionA DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II. [GOC:txnOH-2018]
DNA-binding transcription activator activity, RNA polymerase II-specificmolecular functionA DNA-binding transcription factor activity that activates or increases transcription of specific gene sets transcribed by RNA polymerase II. [GOC:aruk, GOC:txnOH-2018, PMID:20737563, PMID:27145859]
nuclear steroid receptor activitymolecular functionCombining with a steroid hormone and transmitting the signal within the cell to initiate a change in cell activity or function. [GOC:signaling, PMID:14708019]
steroid bindingmolecular functionBinding to a steroid, any of a large group of substances that have in common a ring system based on 1,2-cyclopentanoperhydrophenanthrene. [GOC:jl, ISBN:0198506732]
protein bindingmolecular functionBinding to a protein. [GOC:go_curators]
zinc ion bindingmolecular functionBinding to a zinc ion (Zn). [GOC:ai]
AF-2 domain bindingmolecular functionBinding to an AF-2 protein domain, a highly conserved ligand-dependent transactivation domain which is essential for receptor-mediated transcriptional activation. [PMID:9682036]
sequence-specific double-stranded DNA bindingmolecular functionBinding to double-stranded DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA, e.g. promotor binding or rDNA binding. [GOC:dos, GOC:sl]
estrogen response element bindingmolecular functionBinding to an estrogen response element (ERE), a conserved sequence found in the promoters of genes whose expression is regulated in response to estrogen. [GOC:ecd, PMID:15036253, PMID:17975005]
nuclear receptor activitymolecular functionA DNA-binding transcription factor activity regulated by binding to a ligand that modulates the transcription of specific gene sets transcribed by RNA polymerase II. Nuclear receptor ligands are usually lipid-based (such as a steroid hormone) and the binding of the ligand to its receptor often occurs in the cytosol, which leads to its translocation to the nucleus. [GOC:txnOH-2018, PMID:23457262]

Located In

This protein is located in 1 target(s):

TargetCategoryDefinition
nucleoplasmcellular componentThat part of the nuclear content other than the chromosomes or the nucleolus. [GOC:ma, ISBN:0124325653]

Active In

This protein is active in 1 target(s):

TargetCategoryDefinition
nucleuscellular componentA membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators]

Part Of

This protein is part of 1 target(s):

TargetCategoryDefinition
chromatincellular componentThe ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome. [GOC:elh, PMID:20404130]

Involved In

This protein is involved in 6 target(s):

TargetCategoryDefinition
regulation of DNA-templated transcriptionbiological processAny process that modulates the frequency, rate or extent of cellular DNA-templated transcription. [GOC:go_curators, GOC:txnOH]
positive regulation of transcription by RNA polymerase IIbiological processAny process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter. [GOC:go_curators, GOC:txnOH]
retinoic acid receptor signaling pathwaybiological processThe series of molecular signals generated as a consequence of a retinoic acid receptor binding to one of its physiological ligands. [GOC:dgh]
positive regulation of cold-induced thermogenesisbiological processAny process that activates or increases the frequency, rate or extent of cold-induced thermogenesis. [PMID:27876809]
regulation of transcription by RNA polymerase IIbiological processAny process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II. [GOC:go_curators, GOC:txnOH]
intracellular steroid hormone receptor signaling pathwaybiological processThe series of molecular signals initiated by a steroid binding to an intracellular steroid hormone receptor. [GOC:mah, GOC:signaling]