Page last updated: 2024-08-07 13:25:14
Estrogen-related receptor gamma
An estrogen-related receptor gamma that is encoded in the genome of human. [PRO:DNx, UniProtKB:P62508]
Synonyms
ERR gamma-2;
Estrogen receptor-related protein 3;
Nuclear receptor subfamily 3 group B member 3
Research
Bioassay Publications (10)
Timeframe | Studies on this Protein(%) | All Drugs % |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 3 (30.00) | 29.6817 |
2010's | 6 (60.00) | 24.3611 |
2020's | 1 (10.00) | 2.80 |
Compounds (10)
Drugs with Inhibition Measurements
Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
---|---|---|---|---|---|
bisphenol a | Homo sapiens (human) | IC50 | 0.0090 | 2 | 2 |
4-cumylphenol | Homo sapiens (human) | IC50 | 0.0139 | 1 | 1 |
4-[1-[4-[2-(dimethylamino)ethoxy]phenyl]-2-phenylbut-1-enyl]phenol | Homo sapiens (human) | IC50 | 0.3485 | 4 | 4 |
afimoxifene | Homo sapiens (human) | IC50 | 0.0084 | 2 | 3 |
tamoxifen | Homo sapiens (human) | IC50 | 0.0622 | 1 | 1 |
4-hydroxytoremifene | Homo sapiens (human) | IC50 | 0.0100 | 2 | 3 |
gsk 4716 | Homo sapiens (human) | IC50 | 2.0000 | 1 | 1 |
n'-((1e)-(4-(diethylamino)phenyl)methylene)-4-hydroxybenzohydrazide | Homo sapiens (human) | IC50 | 0.6600 | 1 | 1 |
gsk5182 | Homo sapiens (human) | IC50 | 0.1464 | 6 | 7 |
Drugs with Activation Measurements
Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
---|---|---|---|---|---|
4-[1-[4-[2-(dimethylamino)ethoxy]phenyl]-2-phenylbut-1-enyl]phenol | Homo sapiens (human) | EC50 | 0.0150 | 1 | 1 |
diethylstilbestrol | Homo sapiens (human) | EC50 | 0.6300 | 2 | 2 |
afimoxifene | Homo sapiens (human) | EC50 | 0.0150 | 1 | 1 |
gsk 4716 | Homo sapiens (human) | EC50 | 1.2748 | 4 | 4 |
gsk 4716 | Homo sapiens (human) | Kd | 5.0000 | 1 | 1 |
n'-((1e)-(4-(diethylamino)phenyl)methylene)-4-hydroxybenzohydrazide | Homo sapiens (human) | EC50 | 0.1300 | 2 | 2 |
Enables
This protein enables 10 target(s):
Target | Category | Definition |
---|---|---|
DNA-binding transcription factor activity, RNA polymerase II-specific | molecular function | A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II. [GOC:txnOH-2018] |
DNA-binding transcription activator activity, RNA polymerase II-specific | molecular function | A DNA-binding transcription factor activity that activates or increases transcription of specific gene sets transcribed by RNA polymerase II. [GOC:aruk, GOC:txnOH-2018, PMID:20737563, PMID:27145859] |
nuclear steroid receptor activity | molecular function | Combining with a steroid hormone and transmitting the signal within the cell to initiate a change in cell activity or function. [GOC:signaling, PMID:14708019] |
steroid binding | molecular function | Binding to a steroid, any of a large group of substances that have in common a ring system based on 1,2-cyclopentanoperhydrophenanthrene. [GOC:jl, ISBN:0198506732] |
protein binding | molecular function | Binding to a protein. [GOC:go_curators] |
zinc ion binding | molecular function | Binding to a zinc ion (Zn). [GOC:ai] |
AF-2 domain binding | molecular function | Binding to an AF-2 protein domain, a highly conserved ligand-dependent transactivation domain which is essential for receptor-mediated transcriptional activation. [PMID:9682036] |
sequence-specific double-stranded DNA binding | molecular function | Binding to double-stranded DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA, e.g. promotor binding or rDNA binding. [GOC:dos, GOC:sl] |
estrogen response element binding | molecular function | Binding to an estrogen response element (ERE), a conserved sequence found in the promoters of genes whose expression is regulated in response to estrogen. [GOC:ecd, PMID:15036253, PMID:17975005] |
nuclear receptor activity | molecular function | A DNA-binding transcription factor activity regulated by binding to a ligand that modulates the transcription of specific gene sets transcribed by RNA polymerase II. Nuclear receptor ligands are usually lipid-based (such as a steroid hormone) and the binding of the ligand to its receptor often occurs in the cytosol, which leads to its translocation to the nucleus. [GOC:txnOH-2018, PMID:23457262] |
Located In
This protein is located in 1 target(s):
Target | Category | Definition |
---|---|---|
nucleoplasm | cellular component | That part of the nuclear content other than the chromosomes or the nucleolus. [GOC:ma, ISBN:0124325653] |
Active In
This protein is active in 1 target(s):
Target | Category | Definition |
---|---|---|
nucleus | cellular component | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators] |
Part Of
This protein is part of 1 target(s):
Target | Category | Definition |
---|---|---|
chromatin | cellular component | The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome. [GOC:elh, PMID:20404130] |
Involved In
This protein is involved in 6 target(s):
Target | Category | Definition |
---|---|---|
regulation of DNA-templated transcription | biological process | Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. [GOC:go_curators, GOC:txnOH] |
positive regulation of transcription by RNA polymerase II | biological process | Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter. [GOC:go_curators, GOC:txnOH] |
retinoic acid receptor signaling pathway | biological process | The series of molecular signals generated as a consequence of a retinoic acid receptor binding to one of its physiological ligands. [GOC:dgh] |
positive regulation of cold-induced thermogenesis | biological process | Any process that activates or increases the frequency, rate or extent of cold-induced thermogenesis. [PMID:27876809] |
regulation of transcription by RNA polymerase II | biological process | Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II. [GOC:go_curators, GOC:txnOH] |
intracellular steroid hormone receptor signaling pathway | biological process | The series of molecular signals initiated by a steroid binding to an intracellular steroid hormone receptor. [GOC:mah, GOC:signaling] |