oxacillin profile

Oxacillin: An antibiotic similar to FLUCLOXACILLIN used in resistant staphylococci infections. [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

oxacillin : A penicillin antibiotic carrying a 5-methyl-3-phenylisoxazole-4-carboxamide group at position 6beta. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

ID Source	ID
PubMed CID	6196
CHEMBL ID	819
CHEBI ID	7809
SCHEMBL ID	3817
MeSH ID	M0015618

Synonym
oxazocillin
4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 3,3-dimethyl-6-[[(5-methyl-3-phenyl-4-isoxazolyl)carbonyl]amino]-7-oxo-, (2s,5r,6r)-
penicillin, (5-methyl-3-phenyl-4-isoxazolyl)-
4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 3,3-dimethyl-6-(((5-methyl-3-phenyl-4-isoxazolyl)carbonyl)amino)-7-oxo-, (2s-(2.alpha.,5.alpha.,6.beta.))-
mpi-penicillin
(2s,5r,6r)-3,3-dimethyl-6-[(5-methyl-3-phenyl-isoxazole-4-carbonyl)amino]-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
CHEBI:7809 ,
(5-methyl-3-phenyl-4-isoxazolyl)penicillin
2,2-dimethyl-6beta-(5-methyl-3-phenyl-1,2-oxazole-4-carboxamido)penam-3alpha-carboxylic acid
6beta-(5-methyl-3-phenylisoxazol-4-yl)penicillanic acid
(2s,5r,6r)-3,3-dimethyl-6-{[(5-methyl-3-phenylisoxazol-4-yl)carbonyl]amino}-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
5-methyl-3-phenyl-4-isoxazolyl-penicillin
C07334
66-79-5
oxacillin
DB00713
4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 3,3-dimethyl-6-(5-methyl-3-phenyl-4-isoxazolecarboxamide)-7-oxo-
oxacillin [inn:ban]
einecs 200-635-5
oxacilline [inn-french]
prostaphlyn
ossacillina [dcit]
oxazocilline
mpi-pc
4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 3,3-dimethyl-6-(((5-methyl-3-phenyl-4-isoxazolyl)carbonyl)amino)-7-oxo-, (2s-(2alpha,5alpha,6beta))-
penicillin, methylphenylisoxazolyl
oxacillinum [inn-latin]
oxacilina [inn-spanish]
CHEMBL819
oxacillin (inn)
oxacilina (tn)
D08307
(2s,5r,6r)-3,3-dimethyl-6-[(5-methyl-3-phenyl-1,2-oxazole-4-carbonyl)amino]-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
methylphenylisoxazolyl penicillin
uh95vd7v76 ,
unii-uh95vd7v76
ossacillina
oxacillinum
oxacilline
oxacilina
bdbm50350483
(2s,5r,6r)-3,3-dimethyl-6-(5-methyl-3-phenyl-1,2-oxazole-4-amido)-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
oxacillin [inn]
4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 3,3-dimethyl-6-(((5-methyl-3-phenyl-4-isoxazolyl)carbonyl)amino)-7-oxo-,(2s,5r,6r)-
oxacillin [mi]
oxacillin [who-dd]
oxacillin [vandf]
oxacillin [mart.]
EPITOPE ID:181859
BRD-K96786677-236-01-6
SCHEMBL3817
5-methyl-3-phenyl-4-isooxazolylpenicillin
DTXSID8023397 ,
Q418725
oxacillin,(s)
oxo-4-thia-1-azabicyclo[3.2.0]heptane-
(2s,5r,6r)-3,3-dimethyl-6-(5-methyl-3-
phenylisoxazole-4-carboxamido)-7-
BRD-K96786677-236-02-4
gtpl10943
EN300-19766050
CS-0013715
HY-B0925A
oxacilline (inn-french)
oxacillin (mart.)
dtxcid403397
oxacillina
j01cf04
oxacillinum (inn-latin)
oxacilina (inn-spanish)

Excerpt	Reference	Relevance
"Oxacillin is an alternative for the treatment of Staphylococcus spp. "	( Antimicrobial resistance and persistence of Staphylococcus epidermidis clones in a Brazilian university hospital. Camargo, CH; de Almeida Sampaio, R; de Souza da Cunha, Mde L; Martins, A; Pereira, VC; Riboli, DF, 2013)	1.83
"Oxacillin is an alternative treatment of choice for CoNS infections; however, resistance to oxacillin can have a substantial impact on healthcare by adversely affecting morbidity and mortality."	( Coagulase-negative staphylococci strains resistant to oxacillin isolated from neonatal blood cultures. Cunha, Mde L; Pereira, VC, 2013)	1.36
"CI oxacillin is an effective alternative to II oxacillin for the treatment of IE caused by MSSA and may improve microbiological cure."	( Continuous versus intermittent infusion of oxacillin for treatment of infective endocarditis caused by methicillin-susceptible Staphylococcus aureus. Crawford, GE; Frei, CR; Green, K; Hughes, DW; Lewis, JS; Maxwell, PR; Patterson, JE, 2009)	1.13
"Oxacillin continues to be an important agent in the treatment of staphylococcal infections; many generic products are available and the only requirement for their approval is demonstration of pharmaceutical equivalence. "	( In vitro and in vivo comparison of the anti-staphylococcal efficacy of generic products and the innovator of oxacillin. Agudelo, M; Rodriguez, CA; Vesga, O; Zuluaga, AF, 2010)	2.02

Excerpt	Reference	Relevance
"Oxacillin has been one of the main drugs used for the treatment of staphylococcal infections; however, a large number of S."	( Methicillin resistance in Staphylococcus aureus and coagulase-negative staphylococci: epidemiological and molecular aspects. Cunha, Mde L; Martins, A, 2007)	1.06
"Oxacillin has high affinity for PBP3 of E."	( [Relation between PBPs (penicillin-binding proteins) and growth curves of Escherichia coli submitted to ampicillin and oxacillin]. Crokaert, F; Lismont, MJ; Van der Linden, E; Yourassowsky, E, 1984)	1.2
"Oxacillin, however, has never been directly implicated."	( Oxacillin nephritis. Guze, LB; Oill, PA; Tillman, DB, 1980)	2.43
"Oxacillin has not been shown to penetrate the blood-aqueous barrier, and should not be used systemically."	( Systemic antibiotics for use in ocular infections--penicillin-resistant Staphylococcus. Schechter, RJ, 1978)	0.98

Excerpt	Reference	Relevance
"Oxacillin may thus inhibit the elimination of methotrexate."	( Pharmacokinetic interaction between high-dose methotrexate and oxacillin. Lagrange, F; Molimard, M; Moore, N; Péhourcq, F; Titier, K, 2002)	1.28

Excerpt	Reference	Relevance
"Oxacillin treatment was successful in 19 patients (73%)."	( Continuous-infusion oxacillin for the treatment of burn wound cellulitis. Namias, N; Pizano, LR; Schulman, CI; Schuster, KM; Ward, CG; Wilson, D, 2009)	1.4
"The oxacillin treatment started at anaesthetic induction and was carried on for 72 hours."	( [Prophylactic antibiotic therapy using oxacillin (Bristopen) in pediatric orthopedic surgery]. Bernière, J; Boudet, L; Goldenberg, H; Granados, M; Lassaux, A; Scemama, MP; Schrayer, S, 1989)	1.03
"Cotreatment with oxacillin appears to reduce the availability of PBP2a to assist in this repair, thereby rendering the MRSA cells more susceptible to the β-lactam."	( Impact of FtsZ Inhibition on the Localization of the Penicillin Binding Proteins in Methicillin-Resistant Staphylococcus aureus. Al-Tameemi, HM; Boyd, JM; Ferrer-González, E; Huh, H; Lee, SH; Pilch, DS, 2021)	0.95
"Upon treatment with oxacillin, 81 proteins (65 up-regulated, 16 down-regulated) were shown differentially expressed in MRSA (p < 0.05)."	( Label-free quantitative proteomics analysis of antibiotic response in Staphylococcus aureus to oxacillin. Chen, D; Hu, Y; Lam, H; Liu, X; Pai, PJ, 2014)	0.94

Excerpt	Reference	Relevance
" Change of medication to an alternative penicillinase-resistant penicillin or to penicillin G is suggested as a safe procedure for completion of antistaphylococcal therapy in patient who develop oxacillin-related hepatotoxicity."	( Reversible oxacillin hepatotoxicity. Olans, RN; Weiner, LB, 1976)	0.83
"68 patients (from newborns to 18 years of age) were studied prospectively for adverse effects associated with methicillin, nafcillin and oxacillin."	( Adverse effects of methicillin, nafcillin and oxacillin in pediatric patients. DeBolt, SL; Nahata, MC; Powell, DA, 1982)	0.73
"This study compared adverse drug reactions (ADRs) to oxacillin with those to nafcillin and other antibiotics."	( Higher occurrence of hepatotoxicity and rash in patients treated with oxacillin, compared with those treated with nafcillin and other commonly used antimicrobials. Alvarez, AM; Gomez, MM; Maraqa, NF; Rathore, MH, 2002)	0.8
" All patients were included in the adverse drug reaction analysis; 1,252 were evaluable for purposes of evaluating treatment efficacy."	( Evaluation of the efficacy and safety of outpatient parenteral antimicrobial therapy for infections with methicillin-sensitive Staphylococcus aureus. Dalovisio, JR; Jiang, X; Tice, AD; Wynn, M, 2005)	0.33
"Vancomycin was associated with a significantly greater number of side effects than was ceftriaxone, cefazolin, or oxacillin, and nafcillin was associated with a significantly greater number of adverse events than ceftriaxone."	( Evaluation of the efficacy and safety of outpatient parenteral antimicrobial therapy for infections with methicillin-sensitive Staphylococcus aureus. Dalovisio, JR; Jiang, X; Tice, AD; Wynn, M, 2005)	0.54

Excerpt	Reference	Relevance
" application of broad spectrum penicillins (ampicillin, mezlocillin, carbenicillin) alone or combined with oxacillin (concomitantly) in different dosages to normal volunteers, the course of serum levels and recovery from urine were assessed and pharmacokinetic data were calculated for a 1-compartment model, in some cases also for a 2-compartment model."	( [Pharmacokinetic studies on broad spectrum antibiotic combinations of penicillin and oxacillin in normal volunteers (author's transl)]. Adam, D; Bauer, W; Seitz, B; Voigt, I, 1979)	0.7
" Up to five pharmacokinetic equations, which are voluntarily defined by the user, are simultaneously fitted to observed time courses."	( A pharmacokinetic analysis program (multi) for microcomputer. Nakagawa, T; Tanigawara, Y; Uno, T; Yamaoka, K, 1981)	0.26
"A pharmacokinetic analysis program based on a tank-in-series model, MULTI(TIS), was developed for the evaluation of dose-dependency in the local disposition of a drug."	( Pharmacokinetic analysis program based on tank-in-series model, MULTI(TIS), for evaluation of capacity-limited local disposition. Fukumura, K; Higashimori, M; Nakagawa, T; Yamaoka, K, 1998)	0.3
" pharmacokinetic data on 670 drugs representing, to our knowledge, the largest publicly available set of human clinical pharmacokinetic data."	( Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Lombardo, F; Obach, RS; Waters, NJ, 2008)	0.35
" High-dose oxacillin delivered by continuous infusion is a valuable strategy to achieve our pharmacokinetic target (4× MIC) at the site of action at H24."	( High-dose continuous oxacillin infusion results in achievement of pharmacokinetics targets in critically ill patients with deep sternal wound infections following cardiac surgery. Dermu, M; Flécher, E; Launey, Y; Malherbe, A; Mallédant, Y; Nesseler, N; Piau, C; Seguin, P; Tribut, O; Verdier, MC, 2014)	1.11

Excerpt	Reference	Relevance
"The in vitro activity of sisomicin and netilmicin alone and in combination with nafcillin, oxacillin and methicillin against 30 strains of enterococci was investigated."	( In vitro activity of sisomicin and netilmicin alone and in combination with nafcillin, oxacillin and methicillin against enterococci. Glotzbecker, C; Watanakunakorn, C, 1978)	0.7
"The in vitro activity of nafcillin, oxacillin, and methicillin alone and in combination with gentamicin and tobramycin against 30 strains of enterococci was investigated."	( Comparative in vitro activity of nafcillin, oxacillin, and methicillin in combination with gentamicin and tobramycin against enterococci. Glotzbecker, C; Watanakunakorn, C, 1977)	0.79
"The effectiveness of three semisynthetic, penicillinase-resistant penicillins alone and in combination with gentamicin was tested against 29 clinical isolates of enterococci."	( Comparative synergistic activity of nafcillin, oxacillin, and methicillin in combination with gentamicin against. Glew, RH; Millering, RS; Wennersten, C, 1975)	0.51
"The beta-lactamase inhibitor, clavulanic acid, was combined with amoxicillin and with ticarcillin for in vitro studies with 586 staphylococci: 97 stock cultures of oxacillin-resistant strains recovered before 1982, and 489 blood or wound isolates collected from 40 separate medical centers during 1987-1988 (300 were oxacillin resistant)."	( Antistaphylococcal activity of amoxicillin and ticarcillin when combined with clavulanic acid. Evaluation of oxacillin-resistant and oxacillin-susceptible isolates. Barry, AL, )	0.54
" Cl934 was also tested by the killing curve method, alone and in combination with coumermycin."	( Comparative in vitro activity of CI934, a new fluoroquinolone, alone and in combination with coumermycin, against gram-positive bacteria. Grenier, P; Klastersky, J; van der Auwera, P; Vandermies, A, 1987)	0.27
" This study demonstrated the efficacy of penicillin and clavulanic acid in the treatment of infections caused by Bacteroides fragilis alone or in combination with beta-lactamase-producing aerobic bacteria."	( Antibiotic and clavulanic acid treatment of subcutaneous abscesses caused by Bacteroides fragilis alone or in combination with aerobic bacteria. Brook, I; Coolbaugh, JC; Walker, RI, 1983)	0.27
"The in vitro activity of rifampin alone and in combination with oxacillin was determined for 75 Staphylococcus aureus strains (64 susceptible and 11 resistant to oxacillin)."	( In vitro activity of rifampin in combination with oxacillin against Staphylococcus aureus. Goldmann, DA; Maduri Traczewski, M; Murphy, P, 1983)	0.76
"The activity of fusidic acid alone and in combination with gentamicin, oxacillin, rifampicin, fosfomycin and ciprofloxacin was investigated against 36 strains of Staphylococcus aureus."	( In-vitro antibacterial activity of fusidic acid alone and in combination with other antibiotics against methicillin-sensitive and -resistant Staphylococcus aureus. Caillon, J; Drugeon, HB; Juvin, ME, 1994)	0.52
" For this reason the anti-staphylococcal potency of the new drug, alone or in combination with other drugs was further characterized."	( Antistaphylococcal activity of cefdinir, a new oral third-generation cephalosporin, alone and in combination with other antibiotics, at supra- and sub-MIC levels. Debbia, EA; Marchese, A; Pesce, A; Saverino, D; Schito, GC, 1995)	0.29
"16H(2)O (Ge(2)Ti(6)W(18)), in combination with a beta-lactam oxacillin against methicillin-resistant and vancomycin-resistant Staphylococcus aureus (characterized by possessing the penicillin-binding protein 2' (PBP2') as a cell-wall synthesis enzyme) with a high initial inoculum of 1 x 10(8) cfu/ml (for in vivo test) was investigated with a help of the growth curve and the reverse transcription polymerase chain reaction (RT-PCR) analyses."	( Synergistic effect of polyoxometalates in combination with oxacillin against methicillin-resistant and vancomycin-resistant Staphylococcus aureus: a high initial inoculum of 1 x 108 cfu/ml for in vivo test. Fujita, Y; Iijima, J; Inoue, M; Matsumoto, N; Oda, M; Suzuki, T; Yamase, T, 2006)	0.82
" Determination of MIC alone or in combination with cefazolin/oxacillin against Staphylococcus spp."	( Antibacterial activity of allicin alone and in combination with beta-lactams against Staphylococcus spp. and Pseudomonas aeruginosa. Cai, Y; Liang, BB; Pei, F; Wang, R, 2007)	0.58
" iwayomogi oil combined with oxacillin resulted in synergism, or additive effects."	( Antibacterial effects of vulgarone B from Artemisia iwayomogi alone and in combination with oxacillin. Byun, YH; Chung, EY; Chung, HS; Lee, YH; Shin, EJ; Shin, S, 2009)	0.86
" From those results we performed the checkerboard test to determine the synergism of EM in combination with ampicillin (AM) or oxacillin (OX) against all strains."	( Synergistic effect of emodin in combination with ampicillin or oxacillin against methicillin-resistant Staphylococcus aureus. Choi, JG; Jeong, GS; Kang, OH; Keum, JH; Kim, SB; Kim, YC; Kwon, DY; Lee, YS; Oh, YC; Shin, DW, 2010)	0.81
" In the present study, we firstly found that artesunate in combination with oxacillin was capable of protecting mice challenged with live MRSA WHO-2 (WHO-2) and the protection was related to the reduced TNF-α and IL-6 levels and decreased bacterial load."	( Artesunate in combination with oxacillin protect sepsis model mice challenged with lethal live methicillin-resistant Staphylococcus aureus (MRSA) via its inhibition on proinflammatory cytokines release and enhancement on antibacterial activity of oxacilli Cao, H; Cen, Y; Jiang, W; Li, B; Li, J; Liu, X; Pan, X; Zheng, J; Zheng, X; Zhou, H, 2011)	0.88
"The in vitro antimicrobial activities of usnic acid were evaluated in combination with five therapeutically available antibiotics, using checkerboard microdilution assay against methicillin-resistant clinical isolates strains of Staphylococcus aureus."	( In vitro interaction of usnic acid in combination with antimicrobial agents against methicillin-resistant Staphylococcus aureus clinical isolates determined by FICI and ΔE model methods. Amicosante, G; Bellio, P; Brisdelli, F; Celenza, G; Garbarino, JA; Nicoletti, M; Perilli, M; Piovano, M; Segatore, B; Setacci, D, 2012)	0.38
" Time-kill analysis was performed in three isolates to characterize the kill kinetics of SNH alone and in combination with the antibiotics that engendered synergy in checkerboard assays."	( In vitro activity of sodium new houttuyfonate alone and in combination with oxacillin or netilmicin against methicillin-resistant Staphylococcus aureus. Hu, X; Jiang, J; Li, X; Lu, X; Lu, Y; Ren, Z; Yang, X; You, X; Zhao, L, 2013)	0.62
" In time-kill analysis, SNH at 1/2 MIC in combination with oxacillin at 1/128 to 1/64 MIC or netilmicin at 1/8 to 1/2 MIC decreased the viable colonies by ≥ 2log(10) CFU/mL."	( In vitro activity of sodium new houttuyfonate alone and in combination with oxacillin or netilmicin against methicillin-resistant Staphylococcus aureus. Hu, X; Jiang, J; Li, X; Lu, X; Lu, Y; Ren, Z; Yang, X; You, X; Zhao, L, 2013)	0.86
" aureus (VISA) are limited, but β-lactams in combination with vancomycin have shown synergistic activity against MRSA and VISA."	( Evaluation of vancomycin in combination with piperacillin-tazobactam or oxacillin against clinical methicillin-resistant Staphylococcus aureus Isolates and vancomycin-intermediate S. aureus isolates in vitro. Dilworth, TJ; Dodd, M; Mercier, RC; Ryan, K; Sliwinski, J, 2014)	0.63
" In this work, the proteome responses in MRSA under the stress of a sub-inhibitory dose of a synergistic drug combination of a novel erythromycin derivative, SIPI-8294, and oxacillin, were studied by label-free quantitative proteomics."	( Proteomic response of methicillin-resistant S. aureus to a synergistic antibacterial drug combination: a novel erythromycin derivative and oxacillin. Chen, D; Dong, X; Hu, Y; Lam, H; Liu, X; Pai, PJ; Qian, PY; Zhang, W, 2016)	0.83

Excerpt	Reference	Relevance
"Flucloxacillin, a new isoxazole penicillin, is active against penicillinase-producing strains of Staphylococcus aureus and is well absorbed in man after oral and intramuscular administration."	( Flucloxacillin, a new isoxazolyl penicillin, compared with oxacillin, cloxacillin, and dicloxacillin. Croydon, EA; Rolinson, GN; Sutherland, R, 1970)	1.28
" The anaesthesia increased the absolute bioavailability (F), the mean absorption time (MAT) and the hepatic recovery ratio (F(H)), but caused little change in the local absorption ratio into the portal system (Fa) and the total clearance (CL)."	( Effect of pentobarbital anaesthesia on intestinal absorption and hepatic first-pass metabolism of oxacillin in rats, evaluated by portal-systemic concentration difference. Nakagawa, T; Ueda, S; Yamaoka, K, 1999)	0.52
"The quantitative structure-bioavailability relationship of 232 structurally diverse drugs was studied to evaluate the feasibility of constructing a predictive model for the human oral bioavailability of prospective new medicinal agents."	( QSAR model for drug human oral bioavailability. Topliss, JG; Yoshida, F, 2000)	0.31
"The utilization of the membrane transport protein PEPT1 as a drug delivery system is a promising strategy to enhance the oral bioavailability of drugs."	( Three-dimensional quantitative structure-activity relationship analyses of beta-lactam antibiotics and tripeptides as substrates of the mammalian H+/peptide cotransporter PEPT1. Biegel, A; Brandsch, M; Gebauer, S; Hartrodt, B; Neubert, K; Thondorf, I, 2005)	0.33
" This antibiotic is bactericidal and is orally bioavailable in mice."	( Structure-activity relationship for the oxadiazole class of antibiotics. Antunes, NT; Boudreau, MA; Chang, M; Ding, D; Lastochkin, E; Leemans, E; Lichtenwalter, K; Mobashery, S; O'Daniel, PI; Peng, Z; Pi, H; Schroeder, VA; Song, W; Spink, E; Suckow, MA; Testero, SA; Vakulenko, S; Wolter, WR, 2015)	0.42

Excerpt	Relevance	Reference
" The penicillin type shows almost no improvement in bactericidal activity despite increasing the dosage above a certain level."	( [Bactericidal dosie-activity relationships with E. coli, K. pneumoniae and Staph. aureus (author's transl)]. Shah, PM; Stille, W, 1976)	0.26
" Significant differences in absorption of the antibiotic from the above dosage forms were found."	( [Bioavailability of peroral drug forms of oxacillin]. Batuashvili, TA; Shchedrin, VI; Zak, AF, 1979)	0.52
" Based on the above results, it was concluded that clinical effect of broadcillin 'Banyu' by an intravenous administration is comparable to its intramuscular route and that safety of intravenous usage seems to be verified as long as the above described dosage is followed."	( [Clinical evaluation of intravenous administration of ampicillin-oxacillin (Broadcillin 'Banyu') in bacterial infections in children (author's transl)]. Fujiwara, T; Haruta, T; Honke, K; Kobayashi, Y; Konishi, I; Maruyama, S; Morikawa, Y; Nakamura, K; Nanba, I; Tomizawa, T; Yamamoto, I, 1978)	0.5
"A neonate treated initially with oxacillin intravenously for two weeks and who was receiving phenobarbital for a seizure disorder subsequently failed to achieve therapeutic levels of orally administered dicloxacillin, even when the dosage was as high as 175 mg/kg/day."	( Subtherapeutic dicloxacillin levels in a neonate: possible mechanisms. Hegyi, T; Schwartz, GJ; Spitzer, A, 1976)	0.87
" After a high dosage therapy with oxacillin for some weeks occurred a leucocytopenia which was reversible after discontinuation of this therapy."	( [Oxacillin-induced granulocytopenia]. Bormann, M; Handrick, W; Meister, EM, 1989)	1.47
" Therefore the optimal dosage of perioperative infusion should be high enough to establish steady state by means of sufficiently high serum levels."	( Comparison of serum and coagulum antibiotic levels with respect to protected blood coagulum. Málek, P; Morávek, J, 1986)	0.27
" The treatment group received oxacillin at a dosage of 200 mg/kg/day by six bolus intravenous injections, beginning with anesthetic induction and continuing for 24 hours after the operations."	( Oxacillin prophylaxis in cerebrospinal fluid shunt procedures: results of a randomized open study in 60 hydrocephalic patients. Djindjian, M; Fevrier, MJ; Otterbein, G; Soussy, JC, 1986)	2
" Individual dosage with control of serum levels is, therefore, recommended."	( [Serum level of antibiotics in burn patients]. Csiba, A; Firr, M; Gráber, H; Novák, J; Syposs, T, 1986)	0.27
" Peritoneal dialysis does not alter these dosage requirements."	( The effects of peritoneal dialysis on the physiological disposition of oxacillin, ampicillin and tetracycline in patients with renal disease. Ruedy, J, 1966)	0.48
" Clinical or animal studies are needed to establish whether the higher titers observed with patient serum containing highly protein-bound drugs diluted in low protein-content media would foster inadequate dosage regiments."	( Laboratory evaluation of the serum dilution test in serious staphylococcal infection. Bartlett, RC; Marcon, MJ, 1983)	0.27
" For dicloxacillin, however, the same dosage adjustment is required irrespective of whether administration is single or combined."	( Effects of mezlocillin on the pharmacokinetics of oxacillin and dicloxacillin. Kampf, D, 1983)	0.94
" Against the borderline oxacillin-susceptible strain BOSSA-1, increasing the sulbactam dosage from 500 to 2,000 mg/kg/day while maintaining a fixed dose of ampicillin (1,000 mg/kg/day) by continuous infusion resulted in lower bacterial counts (4."	( Activity of ampicillin-sulbactam and oxacillin in experimental endocarditis caused by beta-lactamase-hyperproducing Staphylococcus aureus. Eliopoulos, GM; Moellering, RC; Pefanis, A; Thauvin-Eliopoulos, C, 1993)	0.87
" Antibiotic dosing was adjusted for renal dysfunction."	( Oral antibiotic treatment of right-sided staphylococcal endocarditis in injection drug users: prospective randomized comparison with parenteral therapy. Daoud, EG; Flexner, C; Goodman, SN; Hartert, TV; Heldman, AW; Kowalski, TE; Lietman, PS; Petty, BG; Pompili, VJ; Ray, SC; Sisson, SD; Tidmore, WC; vom Eigen, KA, 1996)	0.29
" In this study, we have been able to demonstrate the usefulness of a reproducible long-time antimicrobial dosage regime from the internal phase of the implant as compared to surface coated polymers."	( Drug delivery concepts for the efficacious prevention of foreign-body infections. Pulverer, G; Rump, A; Schierholz, JM, 1996)	0.29
" The oxacillin-alone dosage represents a subtherapeutic regimen against the infecting strain in the endocarditis model (L."	( Comparative efficacies of liposomal amikacin (MiKasome) plus oxacillin versus conventional amikacin plus oxacillin in experimental endocarditis induced by Staphylococcus aureus: microbiological and echocardiographic analyses. Bayer, AS; Kupferwasser, LI; Xiong, YQ; Zack, PM, 1999)	1.06
" The dose-response curves were bell shaped, indicating toxic effects for the sensor strain at high concentrations of beta-lactams."	( A luminescent Escherichia coli biosensor for the high throughput detection of beta-lactams. Karp, MT; Kurittu, JS; Valtonen, SJ, 2002)	0.31
"4 and (ii) sigmoidal dose-response curves with cloxacillin (0."	( Restoration of susceptibility of intracellular methicillin-resistant Staphylococcus aureus to beta-lactams: comparison of strains, cells, and antibiotics. Appelbaum, PC; Glupczynski, Y; Lemaire, S; Olivier, A; Tulkens, PM; Van Bambeke, F, 2008)	0.6
" This convenient and pharmacodynamically optimized dosing regimen for oxacillin deserves consideration for patients with IE caused by MSSA."	( Continuous versus intermittent infusion of oxacillin for treatment of infective endocarditis caused by methicillin-susceptible Staphylococcus aureus. Crawford, GE; Frei, CR; Green, K; Hughes, DW; Lewis, JS; Maxwell, PR; Patterson, JE, 2009)	0.85
" However, in vitro dose-response curves for bone chips impregnated with different kinds of antibiotics are not available."	( Impregnation of bone chips with antibiotics and storage of antibiotics at different temperatures: an in vitro study. Bloem, RM; Buma, P; Mathijssen, NM; Petit, PL; Pilot, P; Schreurs, BW, 2010)	0.36
" In a separate experiment, in vitro dose-response curves were established for bone chips impregnated with cefazolin and vancomycin solutions at five different concentrations."	( Impregnation of bone chips with antibiotics and storage of antibiotics at different temperatures: an in vitro study. Bloem, RM; Buma, P; Mathijssen, NM; Petit, PL; Pilot, P; Schreurs, BW, 2010)	0.36
" The in vitro dose-response curves show that the free-zone diameter increases logarithmically with antibiotic concentration."	( Impregnation of bone chips with antibiotics and storage of antibiotics at different temperatures: an in vitro study. Bloem, RM; Buma, P; Mathijssen, NM; Petit, PL; Pilot, P; Schreurs, BW, 2010)	0.36
" The in vitro dose-response curve can be used to determine the optimal concentration(s) for local application."	( Impregnation of bone chips with antibiotics and storage of antibiotics at different temperatures: an in vitro study. Bloem, RM; Buma, P; Mathijssen, NM; Petit, PL; Pilot, P; Schreurs, BW, 2010)	0.36
" Sigmoidal dose-response curves were generated by nonlinear regression fitted to Hill equation to compute maximum effect (Emax), slope (N), and the effective dose reaching 50% of the Emax (ED50)."	( In vitro and in vivo comparison of the anti-staphylococcal efficacy of generic products and the innovator of oxacillin. Agudelo, M; Rodriguez, CA; Vesga, O; Zuluaga, AF, 2010)	0.57
" Further investigation into β-lactam dosing strategies against different BORSA strains is warranted in order to avoid possible therapy failure."	( Diminished in vitro antibacterial activity of oxacillin against clinical isolates of borderline oxacillin-resistant Staphylococcus aureus. Beisser, PS; Croes, S; Deurenberg, RH; Neef, C; Stobberingh, EE; Terporten, PH, 2010)	0.62
" Ceftriaxone can be dosed once daily and is less expensive for outpatient therapy than oxacillin."	( A retrospective comparison of ceftriaxone versus oxacillin for osteoarticular infections due to methicillin-susceptible Staphylococcus aureus. Bommarito, KM; Marcantoni, JR; Marschall, J; Warren, DK; Wieland, BW, 2012)	0.86
" aureus (MRSA) present global challenges to clinicians since therapeutic options are limited and suboptimal dosing contributes to heightened mortality and increased length of hospital stay particularly among the HIV infected patients."	( Oxacillin resistant Staphylococcus aureus among HIV infected and non-infected Kenyan patients. Amukoye, E; Bii, CC; Lucy, M; Ngeranwa, JN; Orinda, GO; Ouko, TT; Wamae, CN, 2010)	1.8
" pneumoniae strains tested were penicillin resistant, standard penicillin dosing for pneumonia may be insufficient given the observed range of pneumococcal penicillin MICs."	( Antimicrobial susceptibility of Streptococcus pneumoniae in adult patients with pneumococcal pneumonia in an urban hospital in Mozambique. Beishuizen, SJ; Bos, JC; Cossa, EO; Gomonda, Edos S; Macome, AC; Madeira, GC; Prins, JM; Schultsz, C; van Steenwijk, RP, 2014)	0.4
" These novel compounds can significantly reduce the dosage of β-lactam antibiotics against MRSA, while this synergistic effect is different from the combination of β-lactams and β-lactamase inhibitors."	( New erythromycin derivatives enhance β-lactam antibiotics against methicillin-resistant Staphylococcus aureus. Chen, D; Dong, X; Ge, H; He, M; Li, J; Li, Z; Lin, H; Shen, S; Ye, RD, 2015)	0.42
" This observation can be a breakthrough in finding alternatives where antibiotic dosage can be significantly reduced, thereby preventing emergence of new multidrug-resistant bacteria."	( Antibiotic hypersensitivity in MRSA induced by special protein aggregates. Aliakbari, F; Christiansen, G; Maleki, B; Morshedi, D; Shariati, P; Sharifirad, A; Tafvizizavareh, S, 2019)	0.51

Role	Description
antibacterial agent	A substance (or active part thereof) that kills or slows the growth of bacteria.
antibacterial drug	A drug used to treat or prevent bacterial infections.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Class	Description
penicillin	Any member of the group of substituted penams containing two methyl substituents at position 2, a carboxylate substituent at position 3 and a carboxamido group at position 6.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein	Taxonomy	Measurement	Average	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
Solute carrier family 22 member 8	Mus musculus (house mouse)	IC50 (µMol)	35.0000	3.0200	3.0200	3.0200	AID1209730
Solute carrier family 15 member 1	Homo sapiens (human)	Ki	12,000.0000	0.1800	3.3933	9.8000	AID238858; AID681115
Solute carrier family 15 member 2	Homo sapiens (human)	Ki	3,305.6550	0.7943	4.2210	8.0000	AID612540
Solute carrier family 15 member 2	Rattus norvegicus (Norway rat)	Ki	3,300.0000	3.0000	6.4778	8.5000	AID681114
MecA	Staphylococcus aureus	IC50 (µMol)	710.0000	1.9000	4.1667	7.4000	AID529294
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Protein	Taxonomy	Measurement	Average	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Process	via Protein(s)	Taxonomy
monoatomic ion transport	Solute carrier family 15 member 1	Homo sapiens (human)
protein transport	Solute carrier family 15 member 1	Homo sapiens (human)
peptide transport	Solute carrier family 15 member 1	Homo sapiens (human)
dipeptide import across plasma membrane	Solute carrier family 15 member 1	Homo sapiens (human)
tripeptide import across plasma membrane	Solute carrier family 15 member 1	Homo sapiens (human)
proton transmembrane transport	Solute carrier family 15 member 1	Homo sapiens (human)
monoatomic ion transport	Solute carrier family 15 member 2	Homo sapiens (human)
protein transport	Solute carrier family 15 member 2	Homo sapiens (human)
peptide transport	Solute carrier family 15 member 2	Homo sapiens (human)
peptidoglycan transport	Solute carrier family 15 member 2	Homo sapiens (human)
xenobiotic transport	Solute carrier family 15 member 2	Homo sapiens (human)
dipeptide transport	Solute carrier family 15 member 2	Homo sapiens (human)
renal absorption	Solute carrier family 15 member 2	Homo sapiens (human)
regulation of nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway	Solute carrier family 15 member 2	Homo sapiens (human)
dipeptide import across plasma membrane	Solute carrier family 15 member 2	Homo sapiens (human)
tripeptide import across plasma membrane	Solute carrier family 15 member 2	Homo sapiens (human)
antibacterial innate immune response	Solute carrier family 15 member 2	Homo sapiens (human)
transport across blood-brain barrier	Solute carrier family 15 member 2	Homo sapiens (human)
proton transmembrane transport	Solute carrier family 15 member 2	Homo sapiens (human)
xenobiotic detoxification by transmembrane export across the plasma membrane	Solute carrier family 15 member 2	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Process	via Protein(s)	Taxonomy
organic anion transmembrane transporter activity	Solute carrier family 22 member 8	Mus musculus (house mouse)
proton-dependent oligopeptide secondary active transmembrane transporter activity	Solute carrier family 15 member 1	Homo sapiens (human)
peptide:proton symporter activity	Solute carrier family 15 member 1	Homo sapiens (human)
tripeptide transmembrane transporter activity	Solute carrier family 15 member 1	Homo sapiens (human)
dipeptide transmembrane transporter activity	Solute carrier family 15 member 1	Homo sapiens (human)
protein binding	Solute carrier family 15 member 2	Homo sapiens (human)
peptide:proton symporter activity	Solute carrier family 15 member 2	Homo sapiens (human)
tripeptide transmembrane transporter activity	Solute carrier family 15 member 2	Homo sapiens (human)
dipeptide transmembrane transporter activity	Solute carrier family 15 member 2	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Process	via Protein(s)	Taxonomy
basolateral plasma membrane	Solute carrier family 22 member 8	Mus musculus (house mouse)
plasma membrane	Solute carrier family 15 member 1	Homo sapiens (human)
brush border	Solute carrier family 15 member 1	Homo sapiens (human)
membrane	Solute carrier family 15 member 1	Homo sapiens (human)
apical plasma membrane	Solute carrier family 15 member 1	Homo sapiens (human)
plasma membrane	Solute carrier family 15 member 1	Homo sapiens (human)
apical plasma membrane	Solute carrier family 15 member 1	Homo sapiens (human)
phagocytic vesicle membrane	Solute carrier family 15 member 2	Homo sapiens (human)
plasma membrane	Solute carrier family 15 member 2	Homo sapiens (human)
membrane	Solute carrier family 15 member 2	Homo sapiens (human)
apical plasma membrane	Solute carrier family 15 member 2	Homo sapiens (human)
extracellular exosome	Solute carrier family 15 member 2	Homo sapiens (human)
apical plasma membrane	Solute carrier family 15 member 2	Homo sapiens (human)
plasma membrane	Solute carrier family 15 member 2	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (1642)

Assay ID	Title	Year	Journal	Article
AID508839	Induction of mecA gene expression in beta-lactamase positive SCCmec type 2 methicillin-resistant Staphylococcus aureus isolate 17256 at MIC after 1 hr by multiplex PCR method	2010	Antimicrobial agents and chemotherapy, Feb, Volume: 54, Issue:2	Effects of ceftobiprole and oxacillin on mecA expression in methicillin-resistant Staphylococcus aureus clinical isolates.
AID761551	Antibacterial activity against Proteus vulgaris 6059 by M07-A9 CLSI method	2013	Bioorganic & medicinal chemistry letters, Aug-01, Volume: 23, Issue:15	Synthesis and antimicrobial activity of imidazole and pyridine appended cholestane-based conjugates.
AID369438	Antimicrobial activity against methicillin-resistant coagulase-negative Staphylococcus after 20 to 24 hrs by broth microdilution method	2007	Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9	In vitro activity of telavancin against gram-positive clinical isolates recently obtained in Europe.
AID574292	Antimicrobial activity against community-acquired pbp3/4-deficient Staphylococcus aureus MW2 serotype USA400 by microdilution method	2008	Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11	Staphylococcus aureus PBP4 is essential for beta-lactam resistance in community-acquired methicillin-resistant strains.
AID475620	Antimicrobial activity against vancomycin-resistant Enterococcus faecalis isolate 12	2010	Bioorganic & medicinal chemistry letters, Apr-01, Volume: 20, Issue:7	7-Phenylplatensimycin and 11-methyl-7-phenylplatensimycin: more potent analogs of platensimycin.
AID528741	Antimicrobial activity against penicillin-resistant Streptococcus agalactiae ATCC BAA-611 harboring PBP-2X V405A mutant gene by agar dilution method	2008	Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8	First molecular characterization of group B streptococci with reduced penicillin susceptibility.
AID356964	Antibacterial activity against vancomycin-resistant Enterococcus faecium F935 expressing VanA after 24 hrs by broth microdilution method	2002	Journal of natural products, Dec, Volume: 65, Issue:12	Antimicrobial activities of naphthazarins from Arnebia euchroma.
AID531576	Antibacterial activity against Gemella morbillorum obtained from complicated skin and skin structure infections by RapID ANA system	2008	Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9	In vitro activity of ceftobiprole against pathogens from two phase 3 clinical trials of complicated skin and skin structure infections.
AID562599	Antimicrobial activity against Staphylococcus haemolyticus clinical isolates assessed as resistant isolates by broth microdilution method	2009	Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11	Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates.
AID285344	Antibacterial activity against community acquired methicillin-resistant Staphylococcus aureus HT20040332 in Mueller-Hinton medium	2007	Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4	Effect of antibiotics on Staphylococcus aureus producing Panton-Valentine leukocidin.
AID1055328	Antibacterial activity against extended spectrum beta-lactamase producing Escherichia coli 09-1 assessed as growth inhibition after 18 hrs by agar dilution method	2013	Journal of natural products, Nov-22, Volume: 76, Issue:11	Identification of elaiophylin derivatives from the marine-derived actinomycete Streptomyces sp. 7-145 using PCR-based screening.
AID531573	Antibacterial activity against Staphylococcus intermedius obtained from complicated skin and skin structure infections by agar dilution method	2008	Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9	In vitro activity of ceftobiprole against pathogens from two phase 3 clinical trials of complicated skin and skin structure infections.
AID324351	Antibacterial activity against methicillin-sensitive Staphylococcus aureus	2007	Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6	Lysostaphin in treatment of neonatal Staphylococcus aureus infection.
AID625282	Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for cirrhosis	2011	PLoS computational biology, Dec, Volume: 7, Issue:12	Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
AID681115	TP_TRANSPORTER: inhibition of Gly-Sar uptake (pH6.0) in Caco-2 cells	2005	European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, Jan, Volume: 59, Issue:1	Interaction of 31 beta-lactam antibiotics with the H+/peptide symporter PEPT2: analysis of affinity constants and comparison with PEPT1.
AID529112	Antimicrobial activity against methicillin-resistant Staphylococcus aureus HPV107 by Etest	2008	Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8	Comparative study of the susceptibilities of major epidemic clones of methicillin-resistant Staphylococcus aureus to oxacillin and to the new broad-spectrum cephalosporin ceftobiprole.
AID717271	Antimicrobial activity against vancomycin-resistant Enterococcus faecalis ATCC 51575 by CLSI protocol based broth microdilution method	2012	Bioorganic & medicinal chemistry letters, Dec-01, Volume: 22, Issue:23	Antibacterial activity of substituted 5-methylbenzo[c]phenanthridinium derivatives.
AID1651735	Antibacterial activity against Vancomycin resistant Enterococcus faecalis MB19 after 24 hrs by microdilution assay	2020	Journal of natural products, 04-24, Volume: 83, Issue:4	Antibacterial and ATP Synthesis Modulating Compounds from
AID508841	Induction of mecA gene expression in beta-lactamase positive SCCmec type 2 methicillin-resistant Staphylococcus aureus isolate 17357 at MIC after 1 hr by multiplex PCR method	2010	Antimicrobial agents and chemotherapy, Feb, Volume: 54, Issue:2	Effects of ceftobiprole and oxacillin on mecA expression in methicillin-resistant Staphylococcus aureus clinical isolates.
AID625291	Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for liver function tests abnormal	2011	PLoS computational biology, Dec, Volume: 7, Issue:12	Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
AID421756	Antibacterial activity against Mycobacterium fortuitum after 72 hrs	2009	Journal of natural products, Mar-27, Volume: 72, Issue:3	Bioactive pyridine-N-oxide disulfides from Allium stipitatum.
AID531574	Antibacterial activity against Aerococcus viridans obtained from complicated skin and skin structure infections by agar dilution method	2008	Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9	In vitro activity of ceftobiprole against pathogens from two phase 3 clinical trials of complicated skin and skin structure infections.
AID373188	Induction of VraSR-dependent tcaA gene expression in Staphylococcus aureus N315 at 16 ug/mL after 30 mins by Northern blot analysis	2007	Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11	Functional characterization of TcaA: minimal requirement for teicoplanin susceptibility and role in Caenorhabditis elegans virulence.
AID521074	Antibacterial activity against group 4-v1 PVL negative community-acquired methicillin-resistant Staphylococcus aureus ST 59 expressing SCCmec type X gene by agar dilution method	2008	Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3	Novel characteristics of community-acquired methicillin-resistant Staphylococcus aureus strains belonging to multilocus sequence type 59 in Taiwan.
AID584302	Antibacterial activity against methicillin-resistant mecA-positive Staphylococcus sciuri subsp. sciuri ATCC 29062T by agar dilution method	2010	Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10	Origin and molecular evolution of the determinant of methicillin resistance in staphylococci.
AID1759649	Antimicrobial activity against vancomycin-resistant Enterococcus faecium clinical isolate 1091282 by CLSI-based broth microdilution assay	2021	European journal of medicinal chemistry, Jul-05, Volume: 219	4-4-(Anilinomethyl)-3-[4-(trifluoromethyl)phenyl]-1H-pyrazol-1-ylbenzoic acid derivatives as potent anti-gram-positive bacterial agents.
AID660261	Ratio of MIC for wild type Escherichia coli JC7623 to MIC for acrAB-deficient Escherichia coli JZM120	2012	European journal of medicinal chemistry, Jun, Volume: 52	Computational analysis of structure-based interactions and ligand properties can predict efflux effects on antibiotics.
AID278911	Antibacterial activity against community-acquired methicillin-resistant Staphylococcus aureus	2007	Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1	In vitro antibacterial activity of the pyrrolopyrazolyl-substituted oxazolidinone RWJ-416457.
AID1691360	Antimicrobial activity against methicillin-resistant Staphylococcus aureus CCARM 3095 assessed as reduction in microbial growth incubated for 18 to 24 hrs by broth microdilution method	2020	European journal of medicinal chemistry, May-01, Volume: 193	Antibacterial AZT derivative regulates metastasis of breast cancer cells.
AID559052	Antibacterial activity against Staphylococcus saprophyticus by CLSI M100-S18 method	2009	Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8	Besifloxacin, a novel fluoroquinolone, has broad-spectrum in vitro activity against aerobic and anaerobic bacteria.
AID1517076	Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC 19498 assessed as reduction in bacterial growth incubated for 24 hrs by serial dilution method	2019	European journal of medicinal chemistry, Dec-01, Volume: 183	Two optimized antimicrobial peptides with therapeutic potential for clinical antibiotic-resistant Staphylococcus aureus.
AID545965	Antimicrobial activity against methicillin-resistant Staphylococcus aureus 16699 by broth dilution method	2010	Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8	Identification of a novel transposon (Tn6072) and a truncated staphylococcal cassette chromosome mec element in methicillin-resistant Staphylococcus aureus ST239.
AID542386	Antimicrobial activity against methicillin-susceptible Staphylococcus aureus ST9 expressing cfr, fexA and erm(C) genes	2009	Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2	Methicillin-resistant and -susceptible Staphylococcus aureus strains of clonal lineages ST398 and ST9 from swine carry the multidrug resistance gene cfr.
AID285924	Antimicrobial activity against methicillin-resistant Staphylococcus aureus ATCC 43300 in human monocyte-derived macrophages at 2.5 ug/ml assessed as bacterial viability after 2 hrs	2007	Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4	Antimicrobial activities of daptomycin, vancomycin, and oxacillin in human monocytes and of daptomycin in combination with gentamicin and/or rifampin in human monocytes and in broth against Staphylococcus aureus.
AID523270	Permeability across Escherichia coli HN1157/pHSG576oxa7 assessed as permeability coefficient in presence of proton uncoupler carbonyl cyanide meta-chlorophenylhydrazone	2010	Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5	Kinetic parameters of efflux of penicillins by the multidrug efflux transporter AcrAB-TolC of Escherichia coli.
AID542625	Antimicrobial activity against Streptococcus pneumoniae R6 harboring PBP2x2349 mutant gene, disruption in PBP1a and aad9 disruption in CiaR gene after 48 hrs by agar dilution method	2009	Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3	An important site in PBP2x of penicillin-resistant clinical isolates of Streptococcus pneumoniae: mutational analysis of Thr338.
AID405584	Induction of blaI mRNA expression in methicillin-resistant Staphylococcus aureus 2884 isolate by RT-PCR	2007	Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7	Identification and phenotypic characterization of a beta-lactam-dependent, methicillin-resistant Staphylococcus aureus strain.
AID68229	Compound was tested for its antibacterial activity against Enterococcus faecium (Vancomycin resistant, VRE) OC 3312.	1998	Bioorganic & medicinal chemistry letters, Jul-21, Volume: 8, Issue:14	Novel inhibitors of bacterial two-component systems with gram positive antibacterial activity: pharmacophore identification based on the screening hit closantel.
AID533929	Antimicrobial activity against linezolid-resistant methicillin-resistant Staphylococcus aureus NRS127 by broth microdilution method	2008	Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12	In vitro activity of TR-700, the antibacterial moiety of the prodrug TR-701, against linezolid-resistant strains.
AID584484	Antibacterial activity against mecA-negative Staphylococcus vitulinus SVMN14 by agar dilution method	2010	Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10	Origin and molecular evolution of the determinant of methicillin resistance in staphylococci.
AID759326	Antibacterial activity against Staphylococcus aureus KCTC 503 after 24 hrs by broth microdilution method	2013	Bioorganic & medicinal chemistry letters, Aug-01, Volume: 23, Issue:15	Synthesis and biological evaluation of rhodanine derivatives bearing a quinoline moiety as potent antimicrobial agents.
AID356965	Antibacterial activity against vancomycin-resistant Enterococcus faecium F935 expressing VanA after 48 hrs by broth microdilution method	2002	Journal of natural products, Dec, Volume: 65, Issue:12	Antimicrobial activities of naphthazarins from Arnebia euchroma.
AID625288	Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for jaundice	2011	PLoS computational biology, Dec, Volume: 7, Issue:12	Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
AID548471	Antibacterial activity against vancomycin-intermediate Staphylococcus aureus Mu50 after 48 hrs by Etest	2009	Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3	Contribution of vraSR and graSR point mutations to vancomycin resistance in vancomycin-intermediate Staphylococcus aureus.
AID595861	Antibacterial activity against methicillin-resistant Staphylococcus aureus clinical isolate after 24 hrs by microdilution method	2011	Journal of medicinal chemistry, May-12, Volume: 54, Issue:9	Exploration of the activity of 7-pyrrolidino-8-methoxyisothiazoloquinolones against methicillin-resistant Staphylococcus aureus (MRSA).
AID530542	Induction of PtcaA::lacZ gene expression in Staphylococcus aureus SH1000 at 1.2 ug/ml after 2 hrs by beta-galactosidase reporter gene assay relative to untreated control	2008	Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8	Staphylococcus aureus cell wall stress stimulon gene-lacZ fusion strains: potential for use in screening for cell wall-active antimicrobials.
AID509061	Antibacterial activity against beta-lactamase positive SCCmec type nontypeable methicillin-resistant Staphylococcus aureus isolate 17329 by broth microdilution method	2010	Antimicrobial agents and chemotherapy, Feb, Volume: 54, Issue:2	Effects of ceftobiprole and oxacillin on mecA expression in methicillin-resistant Staphylococcus aureus clinical isolates.
AID528527	Antimicrobial activity against penicillin-resistant Streptococcus agalactiae B8 by agar dilution method	2008	Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8	First molecular characterization of group B streptococci with reduced penicillin susceptibility.
AID432809	Antimicrobial activity against SCCmec type 1 methicillin-resistant Staphylococcus aureus COL D19455 expressing symporter gene smr1 at 37 degC incubated for 24 hrs by E-test	2008	Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2	Role of a sodium-dependent symporter homologue in the thermosensitivity of beta-lactam antibiotic resistance and cell wall composition in Staphylococcus aureus.
AID1732053	Antibacterial activity against Staphylococcus aureus FDA 209 P	2021	European journal of medicinal chemistry, Apr-05, Volume: 215	Discovery of novel N
AID560521	Antimicrobial activity against SCCmec type III vancomycin-intermediate Staphylococcus aureus isolate xa07029 by agar dilution method	2009	Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9	Prevalence and characterization of heterogeneous vancomycin-intermediate Staphylococcus aureus isolates from 14 cities in China.
AID565760	Antimicrobial activity against oxacillin-susceptible Staphylococcus aureus clinical isolates by broth microdilution method	2009	Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11	Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates.
AID519631	Activity of Brachyspira pilosicoli beta-lactamase OXA-63 expressed in Escherichia coli BL21 (DE3) assessed as compound hydrolysis by spectrophotometry	2008	Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4	Genetic and biochemical characterization of OXA-63, a new class D beta-lactamase from Brachyspira pilosicoli BM4442.
AID564828	Bactericidal activity against methicillin-resistant coagulase-negative Staphylococcus simulans after 24 hrs by plate counting method	2009	Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10	In vitro activities of panduratin A against clinical Staphylococcus strains.
AID693711	Antibacterial activity against quinolone-resistant Staphylococcus aureus CCARM 3505 after 20 hrs by two fold serial dilution assay	2012	European journal of medicinal chemistry, Dec, Volume: 58	Synthesis and antibacterial activity of novel 1,3-diphenyl-1H-pyrazoles functionalized with phenylalanine-derived rhodanines.
AID1294661	Antimicrobial activity against methicillin-resistant Staphylococcus aureus isolate 7a after 24 hrs by agar plate dilution method	2016	European journal of medicinal chemistry, Jun-10, Volume: 115	Anti-methicillin resistant Staphylococcus aureus activity, synergism with oxacillin and molecular docking studies of metronidazole-triazole hybrids.
AID326272	Activity of Escherichia coli K12 beta-lactamase TEM1 relative to penicillin G	2007	Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6	SCO-1, a novel plasmid-mediated class A beta-lactamase with carbenicillinase characteristics from Escherichia coli.
AID369436	Antimicrobial activity against methicillin-resistant Staphylococcus aureus after 20 to 24 hrs by broth microdilution method	2007	Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9	In vitro activity of telavancin against gram-positive clinical isolates recently obtained in Europe.
AID1870142	Antibacterial activity against wild type Staphylococcus aureus 4904/C assessed as reduction in microbial growth incubated for 24 hrs by microdilution assay	2022	Journal of medicinal chemistry, 07-28, Volume: 65, Issue:14	LEGO-Lipophosphonoxins: A Novel Approach in Designing Membrane Targeting Antimicrobials.
AID519462	Antimicrobial activity against oxacillin sensitive and tetracycline resistant Staphylococcus aureus isolate 450MHomodeltamecA with mecA::tetM genotype by broth microdilution method	2008	Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4	Spontaneous deletion of the methicillin resistance determinant, mecA, partially compensates for the fitness cost associated with high-level vancomycin resistance in Staphylococcus aureus.
AID325445	Antibacterial activity against Escherichia coli C921-61 after 14 to 16 hrs by broth dilution method	2007	Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6	Polyamine effects on antibiotic susceptibility in bacteria.
AID1567127	Antimicrobial activity against Streptococcus pyogenes ATCC 19615 incubated for 20 hrs by microdilution method	2019	European journal of medicinal chemistry, Sep-15, Volume: 178	Design, synthesis and biological evaluation of antimicrobial diarylimine and -amine compounds targeting the interaction between the bacterial NusB and NusE proteins.
AID1567122	Antimicrobial activity against Pseudomonas aeruginosa ATCC 27853 incubated for 20 hrs by microdilution method	2019	European journal of medicinal chemistry, Sep-15, Volume: 178	Design, synthesis and biological evaluation of antimicrobial diarylimine and -amine compounds targeting the interaction between the bacterial NusB and NusE proteins.
AID565004	Antimicrobial activity against methicillin-susceptible coagulase-negative Staphylococcus epidermidis after 24 hrs by broth microdilution method	2009	Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10	In vitro activities of panduratin A against clinical Staphylococcus strains.
AID1853469	Antibacterial activity against methicillin-resistant Staphylococcus aureus ST239 (ARLG 1644) assessed as bacterial growth inhibition incubated for 18 to 20 hrs by CLSI based broth microdilution assay	2021	RSC medicinal chemistry, Nov-17, Volume: 12, Issue:11	SF
AID431116	Antibacterial activity against mutated graR gene knockout heterogeneous vancomycin-intermediate Staphylococcus aureus Mu3 after 24 hrs by agar dilution method	2008	Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1	Mutated response regulator graR is responsible for phenotypic conversion of Staphylococcus aureus from heterogeneous vancomycin-intermediate resistance to vancomycin-intermediate resistance.
AID1691359	Antimicrobial activity against methicillin-resistant Staphylococcus aureus CCARM 3090 assessed as reduction in microbial growth incubated for 18 to 24 hrs by broth microdilution method	2020	European journal of medicinal chemistry, May-01, Volume: 193	Antibacterial AZT derivative regulates metastasis of breast cancer cells.
AID765060	Antimicrobial activity against vancomycin-resistant Enterococcus faecalis ATCC 51575 by broth microdilution method	2013	Bioorganic & medicinal chemistry letters, Sep-01, Volume: 23, Issue:17	Antibacterial activity of quinoxalines, quinazolines, and 1,5-naphthyridines.
AID564812	Antimicrobial activity against methicillin-resistant coagulase-negative Staphylococcus haemolyticus after 24 hrs by broth microdilution method	2009	Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10	In vitro activities of panduratin A against clinical Staphylococcus strains.
AID562601	Antimicrobial activity against oxacillin-susceptible Staphylococcus epidermidis clinical isolates assessed as resistant isolates by broth microdilution method	2009	Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11	Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates.
AID340859	Antimicrobial activity against vancomycin-intermediate resistant Staphylococcus aureus Mu50 graR mutant microdilution assay	2007	Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8	Interaction of the GraRS two-component system with the VraFG ABC transporter to support vancomycin-intermediate resistance in Staphylococcus aureus.
AID405604	Decrease in blaI gene expression in oxacillin-dependent methicillin-resistant Staphylococcus aureus 2884D isolate at 0.5 ug/ml by microarray-based transcriptional profiling relative to control	2007	Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7	Identification and phenotypic characterization of a beta-lactam-dependent, methicillin-resistant Staphylococcus aureus strain.
AID574302	Antimicrobial activity against hospital-acquired pbp3-deficient Staphylococcus aureus COL serotype USA500 by microdilution method	2008	Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11	Staphylococcus aureus PBP4 is essential for beta-lactam resistance in community-acquired methicillin-resistant strains.
AID584477	Antibacterial activity against mecA-negative Staphylococcus vitulinus SVMN07 by agar dilution method	2010	Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10	Origin and molecular evolution of the determinant of methicillin resistance in staphylococci.
AID533942	Antimicrobial activity against linezolid-resistant Enterococcus faecalis 413 harboring G2576U mutation in peptidyl transferase centre by broth microdilution method	2008	Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12	In vitro activity of TR-700, the antibacterial moiety of the prodrug TR-701, against linezolid-resistant strains.
AID1517138	Ratio of MIC for resistant Staphylococcus aureus ATCC 25923 for 15 days to MIC for Staphylococcus aureus ATCC 25923 for 24 hrs	2019	European journal of medicinal chemistry, Dec-01, Volume: 183	Two optimized antimicrobial peptides with therapeutic potential for clinical antibiotic-resistant Staphylococcus aureus.
AID559502	Antibacterial activity against ciprofloxacin-susceptible and methicillin-resistant Staphylococcus epidermidis assessed as percent susceptible isolates by CLSI M100-S18 method	2009	Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8	Besifloxacin, a novel fluoroquinolone, has broad-spectrum in vitro activity against aerobic and anaerobic bacteria.
AID509050	Antibacterial activity against beta-lactamase positive SCCmec type 5 methicillin-resistant Staphylococcus aureus isolate 12868 by broth microdilution method	2010	Antimicrobial agents and chemotherapy, Feb, Volume: 54, Issue:2	Effects of ceftobiprole and oxacillin on mecA expression in methicillin-resistant Staphylococcus aureus clinical isolates.
AID520289	Antimicrobial activity against Staphylococcus aureus 2546	2008	Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5	Activities of daptomycin and comparative antimicrobials, singly and in combination, against extracellular and intracellular Staphylococcus aureus and its stable small-colony variant in human monocyte-derived macrophages and in broth.
AID501191	Antimicrobial activity against methicillin sensitive Staphylococcus aureus 375 at 1 unit after 18 hrs by agar diffusion method	2009	Journal of natural products, Oct, Volume: 72, Issue:10	Norselic acids A-E, highly oxidized anti-infective steroids that deter mesograzer predation, from the Antarctic sponge Crella sp.
AID567451	Antimicrobial activity against methicillin-resistant Staphylococcus aureus CGK3 by Etest method	2010	Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9	Development of daptomycin nonsusceptibility with heterogeneous vancomycin-intermediate resistance and oxacillin susceptibility in methicillin-resistant Staphylococcus aureus during high-dose daptomycin treatment.
AID1853607	Antibacterial activity against Enterococcus faecalis clinical isolate 1100440 assessed as inhibition of bacterial growth by CLSI protocol based broth microdilution method	2021	RSC medicinal chemistry, Oct-20, Volume: 12, Issue:10	Design, synthesis, and antibacterial activity of
AID562398	Antimicrobial activity against Staphylococcus aureus clinical isolates assessed as percent susceptible isolates by broth microdilution method	2009	Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11	Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates.
AID356962	Antibacterial activity against Enterococcus faecalis after 24 hrs by broth microdilution method	2002	Journal of natural products, Dec, Volume: 65, Issue:12	Antimicrobial activities of naphthazarins from Arnebia euchroma.
AID356959	Antibacterial activity against Staphylococcus aureus after 48 hrs by broth microdilution method	2002	Journal of natural products, Dec, Volume: 65, Issue:12	Antimicrobial activities of naphthazarins from Arnebia euchroma.
AID564809	Bactericidal activity against methicillin-resistant coagulase-negative Staphylococcus haemolyticus after 24 hrs by plate counting method	2009	Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10	In vitro activities of panduratin A against clinical Staphylococcus strains.
AID1517062	Antibacterial activity against Staphylococcus aureus ATCC 8325.4 assessed as reduction in bacterial growth incubated for 24 hrs by serial dilution method	2019	European journal of medicinal chemistry, Dec-01, Volume: 183	Two optimized antimicrobial peptides with therapeutic potential for clinical antibiotic-resistant Staphylococcus aureus.
AID545966	Antimicrobial activity against methicillin-resistant Staphylococcus aureus 16700 by broth dilution method	2010	Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8	Identification of a novel transposon (Tn6072) and a truncated staphylococcal cassette chromosome mec element in methicillin-resistant Staphylococcus aureus ST239.
AID1517139	Ratio of MIC for resistant Staphylococcus aureus ATCC 29213 for 15 days to MIC for Staphylococcus aureus ATCC 29213 for 24 hrs	2019	European journal of medicinal chemistry, Dec-01, Volume: 183	Two optimized antimicrobial peptides with therapeutic potential for clinical antibiotic-resistant Staphylococcus aureus.
AID565753	Antimicrobial activity against oxacillin-resistant Staphylococcus haemolyticus clinical isolates by broth microdilution method	2009	Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11	Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates.
AID432981	Antimicrobial activity against SCCmec type 1 methicillin-resistant Staphylococcus aureus COL 404 expressing symporter gene smr1 at 37 degC incubated for 24 hrs by E-test	2008	Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2	Role of a sodium-dependent symporter homologue in the thermosensitivity of beta-lactam antibiotic resistance and cell wall composition in Staphylococcus aureus.
AID571931	Antimicrobial activity against Escherichia coli K-12 3-AG300 harboring AcrB-615-628MexB-S623N mutant gene	2009	Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1	Site-directed mutagenesis reveals amino acid residues in the Escherichia coli RND efflux pump AcrB that confer macrolide resistance.
AID558757	Antibacterial activity against homo-Methicillin-resistant and tetracycline-resistant Staphylococcus aureus deltaIP::vraSH14 harboring vraSH14 S329L mutant gene by Etest method	2009	Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8	Selection of heterogeneous vancomycin-intermediate Staphylococcus aureus by imipenem.
AID542616	Antimicrobial activity against Streptococcus pneumoniae R6 harboring PBP2x2349 mutant gene after 48 hrs by agar dilution method	2009	Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3	An important site in PBP2x of penicillin-resistant clinical isolates of Streptococcus pneumoniae: mutational analysis of Thr338.
AID1209731	Drug uptake by mouse OAT3 expressed in CHO cells at 100 uM after 25 mins by HPLC/UV detection method	2013	Drug metabolism and disposition: the biological fate of chemicals, Apr, Volume: 41, Issue:4	Organic anion transporter 3 interacts selectively with lipophilic β-lactam antibiotics.
AID533941	Antimicrobial activity against linezolid-resistant Enterococcus faecalis 412 harboring G2576U mutation in peptidyl transferase centre by broth microdilution method	2008	Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12	In vitro activity of TR-700, the antibacterial moiety of the prodrug TR-701, against linezolid-resistant strains.
AID576136	Antibacterial activity against 10'4 to 10'5 CFU Enterococcus faecalis after 18 hrs by CLSI 2-fold agar dilution method	2010	Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12	In vitro and in vivo activities of LCB01-0371, a new oxazolidinone.
AID1737458	Antibacterial activity against methicillin resistant Staphylococcus aureus S-33 after 16 to 18 hrs by CLSI-based microbroth dilution method	2020	European journal of medicinal chemistry, Jun-01, Volume: 195	Synthesis of novel monocarbonyl curcuminoids, evaluation of their efficacy against MRSA, including ex vivo infection model and their mechanistic studies.
AID543950	Antibacterial activity against oxacillin, chloramphenicol-susceptible and erythromycin, tetracycline-resistant Staphylococcus aureus COL	2009	Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2	Reconstruction of the phenotypes of methicillin-resistant Staphylococcus aureus by replacement of the staphylococcal cassette chromosome mec with a plasmid-borne copy of Staphylococcus sciuri pbpD gene.
AID509632	Antimicrobial activity against Staphylococcus aureus 25 transformant carrying plasmid pKKS25 and expressing erm(T), dfrKtet(L), tet(K), tet(M), mecA and blaZ genes by broth microdilution method	2010	Antimicrobial agents and chemotherapy, Feb, Volume: 54, Issue:2	Identification of a plasmid-borne resistance gene cluster comprising the resistance genes erm(T), dfrK, and tet(L) in a porcine methicillin-resistant Staphylococcus aureus ST398 strain.
AID717273	Antimicrobial activity against methicillin-sensitive Staphylococcus aureus 8325-4 by CLSI protocol based broth microdilution method	2012	Bioorganic & medicinal chemistry letters, Dec-01, Volume: 22, Issue:23	Antibacterial activity of substituted 5-methylbenzo[c]phenanthridinium derivatives.
AID285359	Increase in Panton-Valentine leukocidin level in Staphylococcus aureus LUG855 in CCY medium	2007	Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4	Effect of antibiotics on Staphylococcus aureus producing Panton-Valentine leukocidin.
AID1055337	Antibacterial activity against methicillin-resistant Staphylococcus epidermidis 09-3 assessed as growth inhibition after 18 hrs by agar dilution method	2013	Journal of natural products, Nov-22, Volume: 76, Issue:11	Identification of elaiophylin derivatives from the marine-derived actinomycete Streptomyces sp. 7-145 using PCR-based screening.
AID509059	Antibacterial activity against beta-lactamase positive SCCmec type 3 methicillin-resistant Staphylococcus aureus isolate 14567 by broth microdilution method	2010	Antimicrobial agents and chemotherapy, Feb, Volume: 54, Issue:2	Effects of ceftobiprole and oxacillin on mecA expression in methicillin-resistant Staphylococcus aureus clinical isolates.
AID278910	Antibacterial activity against linezolid-resistant methicillin-resistant Staphylococcus aureus	2007	Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1	In vitro antibacterial activity of the pyrrolopyrazolyl-substituted oxazolidinone RWJ-416457.
AID759323	Antibacterial activity against methicillin-resistant Staphylococcus aureus CCARM 3506 after 24 hrs by broth microdilution method	2013	Bioorganic & medicinal chemistry letters, Aug-01, Volume: 23, Issue:15	Synthesis and biological evaluation of rhodanine derivatives bearing a quinoline moiety as potent antimicrobial agents.
AID511302	Antibacterial activity against methicillin susceptible Staphylococcus aureus by broth dilution method	2010	Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3	Comparative in vitro activities of nemonoxacin (TG-873870), a novel nonfluorinated quinolone, and other quinolones against clinical isolates.
AID560506	Antimicrobial activity against SCCmec type III vancomycin-intermediate Staphylococcus aureus isolate b3k2345 by agar dilution method	2009	Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9	Prevalence and characterization of heterogeneous vancomycin-intermediate Staphylococcus aureus isolates from 14 cities in China.
AID660265	Antimicrobial activity against wild type Escherichia coli expressing AcrAB-TolC efflux pump	2012	European journal of medicinal chemistry, Jun, Volume: 52	Computational analysis of structure-based interactions and ligand properties can predict efflux effects on antibiotics.
AID1651726	Antibacterial activity against Methicillin-resistant Staphylococcus epidermidis MB169 after 24 hrs by microdilution assay	2020	Journal of natural products, 04-24, Volume: 83, Issue:4	Antibacterial and ATP Synthesis Modulating Compounds from
AID1551297	Antibacterial activity against Methicillin-resistant Staphylococcus aureus CCARM 3167 assessed as reduction in bacterial cell growth incubated for 24 hrs by ELISA	2019	European journal of medicinal chemistry, Jun-15, Volume: 172	Synthesis and biological evaluation of tryptophan-derived rhodanine derivatives as PTP1B inhibitors and anti-bacterial agents.
AID1254078	Antibacterial activity against methicillin-resistant Staphylococcus aureus CCARM 3506 after 24 hrs by two-fold serial dilution method	2015	Bioorganic & medicinal chemistry letters, Nov-15, Volume: 25, Issue:22	Synthesis and biological evaluation of 1,3-diaryl pyrazole derivatives as potential antibacterial and anti-inflammatory agents.
AID356961	Antibacterial activity against methicillin-resistant Staphylococcus aureus 8-8S after 48 hrs by broth microdilution method	2002	Journal of natural products, Dec, Volume: 65, Issue:12	Antimicrobial activities of naphthazarins from Arnebia euchroma.
AID565015	Bactericidal activity against methicillin-susceptible coagulase-negative Staphylococcus simulans after 24 hrs by plate counting method	2009	Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10	In vitro activities of panduratin A against clinical Staphylococcus strains.
AID1067069	Antimicrobial activity against quinolone-resistant Staphylococcus aureus clinical isolate 3519 after 20 hrs by two-fold serial dilution technique	2014	European journal of medicinal chemistry, Mar-03, Volume: 74	Synthesis and evaluation of the antimicrobial activities of 3-((5-phenyl-1,3,4-oxadiazol-2-yl)methyl)-2-thioxothiazolidin-4-one derivatives.
AID575336	Antimicrobial activity against Listeria monocytogenes EGD-e at 1 ug after 16 hrs by disk diffusion assay	2010	Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10	The ABC transporter AnrAB contributes to the innate resistance of Listeria monocytogenes to nisin, bacitracin, and various beta-lactam antibiotics.
AID1438622	Antibacterial activity against methicillin-resistant Staphylococcus aureus isolate HT 2002-0417 after 18 hrs by broth microdilution assay	2017	European journal of medicinal chemistry, Mar-10, Volume: 128	Synthesis, surfactant properties and antimicrobial activities of methyl glycopyranoside ethers.
AID27167	Delta logD (logD6.5 - logD7.4)	2000	Journal of medicinal chemistry, Jun-29, Volume: 43, Issue:13	QSAR model for drug human oral bioavailability.
AID545951	Antimicrobial activity against methicillin-resistant Staphylococcus aureus 16651 by broth dilution method	2010	Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8	Identification of a novel transposon (Tn6072) and a truncated staphylococcal cassette chromosome mec element in methicillin-resistant Staphylococcus aureus ST239.
AID1853604	Antibacterial activity against Enterococcus faecalis clinical isolate 1091563 assessed as inhibition of bacterial growth by CLSI protocol based broth microdilution method	2021	RSC medicinal chemistry, Oct-20, Volume: 12, Issue:10	Design, synthesis, and antibacterial activity of
AID1896246	Antibacterial activity against methicillin resistant Staphylococcus aureus FPR3757 assessed as inhibition of bacterial growth incubated for 24 hrs by CLSI based method
AID584483	Antibacterial activity against mecA-negative Staphylococcus vitulinus SVMN13 by agar dilution method	2010	Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10	Origin and molecular evolution of the determinant of methicillin resistance in staphylococci.
AID573122	Antibacterial activity against coagulase-negative and oxacillin-resistant Staphylococcus aureus by CLSI M7-A7 broth microdilution method	2008	Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9	In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States.
AID424422	Antibacterial activity against vancomycin-resistant Staphylococcus aureus HIP15178 isolated from patients surgical wound by broth microdilution method	2008	Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2	Vancomycin-resistant Staphylococcus aureus isolates associated with Inc18-like vanA plasmids in Michigan.
AID405608	Decrease in cell division and morphogenesis-related protein SA2273 N315 gene expression in oxacillin-dependent methicillin-resistant Staphylococcus aureus 2884D isolate at 0.5 ug/ml by microarray-based transcriptional profiling relative to control	2007	Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7	Identification and phenotypic characterization of a beta-lactam-dependent, methicillin-resistant Staphylococcus aureus strain.
AID1759651	Antimicrobial activity against against methicillin-sensitive Staphylococcus aureus clinical isolate 1088060 by CLSI-based broth microdilution assay	2021	European journal of medicinal chemistry, Jul-05, Volume: 219	4-4-(Anilinomethyl)-3-[4-(trifluoromethyl)phenyl]-1H-pyrazol-1-ylbenzoic acid derivatives as potent anti-gram-positive bacterial agents.
AID1759652	Antimicrobial activity against against methicillin-sensitive Staphylococcus aureus clinical isolate 1088105 by CLSI-based broth microdilution assay	2021	European journal of medicinal chemistry, Jul-05, Volume: 219	4-4-(Anilinomethyl)-3-[4-(trifluoromethyl)phenyl]-1H-pyrazol-1-ylbenzoic acid derivatives as potent anti-gram-positive bacterial agents.
AID509058	Antibacterial activity against beta-lactamase positive SCCmec type 3 methicillin-resistant Staphylococcus aureus isolate 12617 by broth microdilution method	2010	Antimicrobial agents and chemotherapy, Feb, Volume: 54, Issue:2	Effects of ceftobiprole and oxacillin on mecA expression in methicillin-resistant Staphylococcus aureus clinical isolates.
AID1242589	Antibacterial activity against methicillin-resistant Staphylococcus aureus R308 clinical isolate after 20 to 24 hrs by CLSI method	2015	ACS medicinal chemistry letters, Jul-09, Volume: 6, Issue:7	Triazole-Linked Glycolipids Enhance the Susceptibility of MRSA to β-Lactam Antibiotics.
AID356960	Antibacterial activity against methicillin-resistant Staphylococcus aureus 8-8S after 24 hrs by broth microdilution method	2002	Journal of natural products, Dec, Volume: 65, Issue:12	Antimicrobial activities of naphthazarins from Arnebia euchroma.
AID431108	Antibacterial activity against heterogeneous vancomycin-intermediate Staphylococcus aureus Mu3 harboring shuttle vector pYT3 after 24 hrs by agar dilution method	2008	Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1	Mutated response regulator graR is responsible for phenotypic conversion of Staphylococcus aureus from heterogeneous vancomycin-intermediate resistance to vancomycin-intermediate resistance.
AID750344	Antibacterial activity against Staphylococcus aureus ATCC 6538 assessed as growth inhibition after 18 hrs by broth microdilution method	2013	European journal of medicinal chemistry, Jun, Volume: 64	Synthesis and evaluation of antimicrobial activity of hydrazones derived from 3-oxido-1H-imidazole-4-carbohydrazides.
AID325151	Antimicrobial activity against Haemophilus parasuis BB 1018	2007	Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6	Beta-lactam resistance in Haemophilus parasuis Is mediated by plasmid pB1000 bearing blaROB-1.
AID1651740	Antibacterial activity against Enterococcus faecium MB152 after 24 hrs by microdilution assay	2020	Journal of natural products, 04-24, Volume: 83, Issue:4	Antibacterial and ATP Synthesis Modulating Compounds from
AID750336	Bactericidal activity against Escherichia coli NCTC 8192 after 18 hrs by broth microdilution method	2013	European journal of medicinal chemistry, Jun, Volume: 64	Synthesis and evaluation of antimicrobial activity of hydrazones derived from 3-oxido-1H-imidazole-4-carbohydrazides.
AID750309	Antibacterial activity against Staphylococcus aureus isolate D17 derived from bone assessed as growth inhibition after 18 hrs by broth microdilution method	2013	European journal of medicinal chemistry, Jun, Volume: 64	Synthesis and evaluation of antimicrobial activity of hydrazones derived from 3-oxido-1H-imidazole-4-carbohydrazides.
AID285347	Antibacterial activity against community acquired methicillin-resistant Staphylococcus aureus HT20010734 in CCY medium	2007	Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4	Effect of antibiotics on Staphylococcus aureus producing Panton-Valentine leukocidin.
AID584304	Antibacterial activity against methicillin-resistant mecA-positive Staphylococcus vitulinus SVMP01 by agar dilution method	2010	Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10	Origin and molecular evolution of the determinant of methicillin resistance in staphylococci.
AID584993	Antibacterial activity against Staphylococcus aureus XU21 by broth microdilution method	2010	Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12	Identification and characterization of the multidrug resistance gene cfr in a Panton-Valentine leukocidin-positive sequence type 8 methicillin-resistant Staphylococcus aureus IVa (USA300) isolate.
AID276296	Antibacterial activity against methicillin-resistant Staphylococcus aureus 20635 at 256 ug/ml	2006	Bioorganic & medicinal chemistry letters, Nov-15, Volume: 16, Issue:22	Solid-phase synthesis and antibacterial activity of hydroxycinnamic acid amides and analogues against methicillin-resistant Staphylococcus aureus and vancomycin-resistant S. aureus.
AID574289	Antimicrobial activity against wild type community-acquired methicillin-resistant Staphylococcus aureus MW2 serotype USA400 by microdilution method	2008	Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11	Staphylococcus aureus PBP4 is essential for beta-lactam resistance in community-acquired methicillin-resistant strains.
AID528523	Antimicrobial activity against penicillin-resistant Streptococcus agalactiae ATCC 12403 by agar dilution method	2008	Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8	First molecular characterization of group B streptococci with reduced penicillin susceptibility.
AID562605	Antimicrobial activity against Staphylococcus aureus clinical isolates assessed as resistant isolates by broth microdilution method	2009	Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11	Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates.
AID529135	Antimicrobial activity against methicillin-resistant Staphylococcus aureus BK2529 assessed as concentration required for minimum inhibition of oxacillin-resistant subpopulation growth by Etest	2008	Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8	Comparative study of the susceptibilities of major epidemic clones of methicillin-resistant Staphylococcus aureus to oxacillin and to the new broad-spectrum cephalosporin ceftobiprole.
AID285358	Increase in Panton-Valentine leukocidin level in community acquired methicillin-resistant Staphylococcus aureus HT20010734 in CYY medium	2007	Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4	Effect of antibiotics on Staphylococcus aureus producing Panton-Valentine leukocidin.
AID431101	Antibacterial activity against graSR gene knockout vancomycin-susceptible Staphylococcus aureus N315 after 48 hrs by agar dilution method	2008	Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1	Mutated response regulator graR is responsible for phenotypic conversion of Staphylococcus aureus from heterogeneous vancomycin-intermediate resistance to vancomycin-intermediate resistance.
AID533939	Antimicrobial activity against linezolid-resistant Staphylococcus aureus 480 harboring G2447U in peptidyl transferase centre by broth microdilution method	2008	Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12	In vitro activity of TR-700, the antibacterial moiety of the prodrug TR-701, against linezolid-resistant strains.
AID534154	Antimicrobial activity against linezolid-resistant Enterococcus faecalis 3124 harboring G2576U mutation in peptidyl transferase centre by broth microdilution method	2008	Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12	In vitro activity of TR-700, the antibacterial moiety of the prodrug TR-701, against linezolid-resistant strains.
AID531558	Antibacterial activity against coagulase-negative Staphylococcus capitis obtained from complicated skin and skin structure infections by agar dilution method	2008	Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9	In vitro activity of ceftobiprole against pathogens from two phase 3 clinical trials of complicated skin and skin structure infections.
AID362544	Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC 25923 after 18 hrs	2008	Journal of natural products, Aug, Volume: 71, Issue:8	Antibacterial cannabinoids from Cannabis sativa: a structure-activity study.
AID1330195	Antibacterial activity against methicillin-resistant Staphylococcus aureus 3506 measured after 24 hrs by two-fold serial dilution method	2016	Bioorganic & medicinal chemistry letters, 12-15, Volume: 26, Issue:24	Synthesis and biological evaluation of chalcone derivatives containing aminoguanidine or acylhydrazone moieties.
AID575145	Antimicrobial activity against methicillin-resistant Staphylococcus aureus isolate NRS71 by broth microdilution method	2010	Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9	Inhibition of antibiotic-resistant Staphylococcus aureus by the broad-spectrum dihydrofolate reductase inhibitor RAB1.
AID432970	Antimicrobial activity against SCCmec type 4 methicillin-resistant Staphylococcus aureus COL MW2 expressing symporter gene smr1 at 42 degC incubated for 24 hrs by E-test	2008	Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2	Role of a sodium-dependent symporter homologue in the thermosensitivity of beta-lactam antibiotic resistance and cell wall composition in Staphylococcus aureus.
AID750301	Bactericidal activity against Staphylococcus aureus isolate F7 derived from ulcer and furuncle after 18 hrs by broth microdilution method	2013	European journal of medicinal chemistry, Jun, Volume: 64	Synthesis and evaluation of antimicrobial activity of hydrazones derived from 3-oxido-1H-imidazole-4-carbohydrazides.
AID285922	Antimicrobial activity against methicillin-resistant Staphylococcus aureus ATCC 43300 in human monocyte-derived macrophages at 0.5 ug/ml assessed as bacterial viability after 4 hrs	2007	Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4	Antimicrobial activities of daptomycin, vancomycin, and oxacillin in human monocytes and of daptomycin in combination with gentamicin and/or rifampin in human monocytes and in broth against Staphylococcus aureus.
AID531557	Antibacterial activity against coagulase-negative Staphylococcus hominis obtained from complicated skin and skin structure infections by agar dilution method	2008	Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9	In vitro activity of ceftobiprole against pathogens from two phase 3 clinical trials of complicated skin and skin structure infections.
AID559507	Antibacterial activity against Staphylococcus saprophyticus assessed as percent susceptible isolates by CLSI M100-S18 method	2009	Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8	Besifloxacin, a novel fluoroquinolone, has broad-spectrum in vitro activity against aerobic and anaerobic bacteria.
AID528499	Antimicrobial activity against low level levofloxacin and methicillin-resistant Staphylococcus aureus JCSC 6768 expressing gyrA Glu84Lys and grlA Ser80Phe mutants by broth microdilution method	2008	Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8	Postantibiotic effects and bactericidal activities of levofloxacin and gatifloxacin at concentrations simulating those of topical ophthalmic administration against fluoroquinolone-resistant and fluoroquinolone-sensitive methicillin-resistant Staphylococcu
AID369435	Antimicrobial activity against methicillin-susceptible Staphylococcus aureus after 20 to 24 hrs by broth microdilution method	2007	Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9	In vitro activity of telavancin against gram-positive clinical isolates recently obtained in Europe.
AID519460	Antimicrobial activity against homotypic oxacillin resistant Staphylococcus aureus isolate 450MHomo by broth microdilution method	2008	Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4	Spontaneous deletion of the methicillin resistance determinant, mecA, partially compensates for the fitness cost associated with high-level vancomycin resistance in Staphylococcus aureus.
AID583694	Antimicrobial activity against methicillin-resistant Staphylococcus aureus 10*3d1 harboring hypothetical protein SA1826 14A(-) and rpoB 621E mutant gene after 24 hrs by Etest method	2010	Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12	An RpoB mutation confers dual heteroresistance to daptomycin and vancomycin in Staphylococcus aureus.
AID278670	Antibacterial activity against methicillin-resistant Staphylococcus aureus isolate 5735	2007	Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1	High-level vancomycin-resistant Staphylococcus aureus isolates associated with a polymicrobial biofilm.
AID581666	Antibacterial activity against Staphylococcus aureus SCV isolated from cystic fibrosis patient in cation-adjusted MH 2 broth assessed as log reduction of extracellular CFU level after 24 hrs	2009	Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4	Intracellular activity of antibiotics in a model of human THP-1 macrophages infected by a Staphylococcus aureus small-colony variant strain isolated from a cystic fibrosis patient: pharmacodynamic evaluation and comparison with isogenic normal-phenotype a
AID519628	Antimicrobial activity against beta-lactamase OXA-63 producing Brachyspira pilosicoli isolate BM4442 isolated from feces of patient with diarrhea by disc diffusion method	2008	Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4	Genetic and biochemical characterization of OXA-63, a new class D beta-lactamase from Brachyspira pilosicoli BM4442.
AID577511	Antibacterial activity against 10'7 CFU/ml wild-type Listeria monocytogenes EGD-e Serovar 1/2a at 1 ug after 16 hrs by disk diffusion assay	2010	Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11	TelA contributes to the innate resistance of Listeria monocytogenes to nisin and other cell wall-acting antibiotics.
AID1559379	Antibacterial activity against Enterobacter aerogenes 188548 expressing AmpC after 16 to 20 hrs by CLSI-based microbroth dilution method	2020	Journal of medicinal chemistry, 03-26, Volume: 63, Issue:6	Discovery of Taniborbactam (VNRX-5133): A Broad-Spectrum Serine- and Metallo-β-lactamase Inhibitor for Carbapenem-Resistant Bacterial Infections.
AID1294674	Antimicrobial activity against methicillin-resistant Staphylococcus aureus isolate 20a after 24 hrs by agar plate dilution method	2016	European journal of medicinal chemistry, Jun-10, Volume: 115	Anti-methicillin resistant Staphylococcus aureus activity, synergism with oxacillin and molecular docking studies of metronidazole-triazole hybrids.
AID431102	Antibacterial activity against mutated graR gene knockout vancomycin-susceptible Staphylococcus aureus N315 after 24 hrs by agar dilution method	2008	Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1	Mutated response regulator graR is responsible for phenotypic conversion of Staphylococcus aureus from heterogeneous vancomycin-intermediate resistance to vancomycin-intermediate resistance.
AID531553	Antibacterial activity against methicillin susceptible Staphylococcus aureus obtained from complicated skin and skin structure infections by agar dilution method	2008	Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9	In vitro activity of ceftobiprole against pathogens from two phase 3 clinical trials of complicated skin and skin structure infections.
AID1242584	Antibacterial activity against methicillin-resistant Staphylococcus aureus R50 clinical isolate after 20 to 24 hrs by CLSI method	2015	ACS medicinal chemistry letters, Jul-09, Volume: 6, Issue:7	Triazole-Linked Glycolipids Enhance the Susceptibility of MRSA to β-Lactam Antibiotics.
AID564811	Antimicrobial activity against methicillin-resistant coagulase-negative Staphylococcus haemolyticus assessed as susceptible isolates after 24 hrs by broth microdilution method	2009	Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10	In vitro activities of panduratin A against clinical Staphylococcus strains.
AID564829	Antimicrobial activity against methicillin-resistant coagulase-negative Staphylococcus sciuri after 24 hrs by broth microdilution method	2009	Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10	In vitro activities of panduratin A against clinical Staphylococcus strains.
AID1079949	Proposed mechanism(s) of liver damage. [column 'MEC' in source]
AID524389	Antibacterial activity against Escherichia coli NKE1367 harboring deletion mutation in acrB, mdtABC protein and plasmid expressing nlpE gene	2010	Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5	Effect of NlpE overproduction on multidrug resistance in Escherichia coli.
AID574553	Decrease in PSMbeta1 levels in Staphylococcus aureus Sanger 252 at subinhibitory concentrations after 24 hrs by RP-HPLC/ESI- MS	2010	Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11	Subinhibitory concentrations of protein synthesis-inhibiting antibiotics promote increased expression of the agr virulence regulator and production of phenol-soluble modulin cytolysins in community-associated methicillin-resistant Staphylococcus aureus.
AID571768	Antimicrobial activity against Escherichia coli K-12 3-AG300 harboring AcrB-I626M mutant gene	2009	Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1	Site-directed mutagenesis reveals amino acid residues in the Escherichia coli RND efflux pump AcrB that confer macrolide resistance.
AID431099	Antibacterial activity against vancomycin-susceptible Staphylococcus aureus N315 harboring intact graR gene after 48 hrs by agar dilution method	2008	Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1	Mutated response regulator graR is responsible for phenotypic conversion of Staphylococcus aureus from heterogeneous vancomycin-intermediate resistance to vancomycin-intermediate resistance.
AID1870140	Antibacterial activity against wild type Staphylococcus aureus 4557/A assessed as reduction in microbial growth incubated for 24 hrs by microdilution assay	2022	Journal of medicinal chemistry, 07-28, Volume: 65, Issue:14	LEGO-Lipophosphonoxins: A Novel Approach in Designing Membrane Targeting Antimicrobials.
AID1175558	Antimicrobial activity against Staphylococcus aureus ATCC 29213 after 24 hrs	2015	Journal of natural products, Jan-23, Volume: 78, Issue:1	Antibacterial ilicicolinic acids C and D and ilicicolinal from Neonectria discophora SNB-CN63 isolated from a termite nest.
AID531559	Antibacterial activity against coagulase-negative Staphylococcus saprophyticus obtained from complicated skin and skin structure infections by agar dilution method	2008	Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9	In vitro activity of ceftobiprole against pathogens from two phase 3 clinical trials of complicated skin and skin structure infections.
AID558755	Antibacterial activity against methicillin-susceptible, tetracycline-resistant and chloramphenicol-resistant Staphylococcus aureus H14-KVR by Etest method	2009	Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8	Selection of heterogeneous vancomycin-intermediate Staphylococcus aureus by imipenem.
AID1698677	Antibacterial activity against Methicillin-resistant Staphylococcus aureus by CLSI method	2020	Bioorganic & medicinal chemistry, 11-15, Volume: 28, Issue:22	Lead optimization of 8-(methylamino)-2-oxo-1,2-dihydroquinolines as bacterial type II topoisomerase inhibitors.
AID543953	Antibacterial activity against tetracycline-resistant Staphylococcus aureus COL-S carrying SSpbpD plasmid	2009	Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2	Reconstruction of the phenotypes of methicillin-resistant Staphylococcus aureus by replacement of the staphylococcal cassette chromosome mec with a plasmid-borne copy of Staphylococcus sciuri pbpD gene.
AID558782	Antibacterial activity against acrB-deficient Salmonella enterica NKS416 harboring acrEF, hns gene by CLSI method	2009	Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8	H-NS modulates multidrug resistance of Salmonella enterica serovar Typhimurium by repressing multidrug efflux genes acrEF.
AID383178	Antimicrobial activity against methicillin-resistant Staphylococcus aureus ATCC 43300	2008	Journal of natural products, Apr, Volume: 71, Issue:4	Sesterterpenoids from the sponge Sarcotragus sp.
AID432985	Antimicrobial activity against SCCmec type 1 methicillin-resistant Staphylococcus aureus COL RUSA11 expressing symporter gene smr1 at 37 degC incubated for 24 hrs by E-test	2008	Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2	Role of a sodium-dependent symporter homologue in the thermosensitivity of beta-lactam antibiotic resistance and cell wall composition in Staphylococcus aureus.
AID525144	Antimicrobial activity against Staphylococcus epidermidis isolate 426-3147L expressing cfr gene by broth microdilution CLSI method	2008	Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6	First report of cfr-mediated resistance to linezolid in human staphylococcal clinical isolates recovered in the United States.
AID571764	Antimicrobial activity against Escherichia coli K-12 3-AG300 harboring acrB::rpsLneo mutant gene	2009	Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1	Site-directed mutagenesis reveals amino acid residues in the Escherichia coli RND efflux pump AcrB that confer macrolide resistance.
AID1209732	Drug uptake by mouse OAT3 expressed in CHO cells at 100 uM after 25 mins by HPLC/UV detection method in presence of probenecid	2013	Drug metabolism and disposition: the biological fate of chemicals, Apr, Volume: 41, Issue:4	Organic anion transporter 3 interacts selectively with lipophilic β-lactam antibiotics.
AID431119	Antibacterial activity against vancomycin-intermediate Staphylococcus aureus Mu50 after 48 hrs by agar dilution method	2008	Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1	Mutated response regulator graR is responsible for phenotypic conversion of Staphylococcus aureus from heterogeneous vancomycin-intermediate resistance to vancomycin-intermediate resistance.
AID564810	Antimicrobial activity against methicillin-resistant coagulase-negative Staphylococcus haemolyticus assessed as resistant isolates after 24 hrs by broth microdilution method	2009	Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10	In vitro activities of panduratin A against clinical Staphylococcus strains.
AID573116	Antibacterial activity against methicillin-resistant Staphylococcus aureus by CLSI M7-A7 broth microdilution method	2008	Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9	In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States.
AID564833	Antimicrobial activity against methicillin-susceptible coagulase-negative Staphylococcus hominis after 24 hrs by broth microdilution method	2009	Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10	In vitro activities of panduratin A against clinical Staphylococcus strains.
AID542389	Antimicrobial activity against Staphylococcus aureus RN4220 transformed with Staphylococcus aureus ST9 plasmid pSCFS3 carrying cfr and fexA genes	2009	Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2	Methicillin-resistant and -susceptible Staphylococcus aureus strains of clonal lineages ST398 and ST9 from swine carry the multidrug resistance gene cfr.
AID1651738	Antibacterial activity against Enterococcus faecium MB2 after 24 hrs by microdilution assay	2020	Journal of natural products, 04-24, Volume: 83, Issue:4	Antibacterial and ATP Synthesis Modulating Compounds from
AID511304	Antibacterial activity against ciprofloxacin and methicillin resistant Staphylococcus aureus by broth dilution method	2010	Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3	Comparative in vitro activities of nemonoxacin (TG-873870), a novel nonfluorinated quinolone, and other quinolones against clinical isolates.
AID556047	Antimicrobial activity against tetracycline-, glycopepeptide-intermediate-resistant Staphylococcus aureus NCTC 8325 by broth microdilution method	2009	Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5	Functional characterization of the sigmaB-dependent yabJ-spoVG operon in Staphylococcus aureus: role in methicillin and glycopeptide resistance.
AID564816	Antimicrobial activity against methicillin-resistant coagulase-negative Staphylococcus epidermidis after 24 hrs by broth microdilution method	2009	Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10	In vitro activities of panduratin A against clinical Staphylococcus strains.
AID548254	Antibacterial activity against vancomycin-susceptible Staphylococcus aureus Mu50omega after 24 hrs by Etest	2009	Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3	Contribution of vraSR and graSR point mutations to vancomycin resistance in vancomycin-intermediate Staphylococcus aureus.
AID1601842	Antibacterial activity against Staphylococcus aureus CMCC 25923 measured after 24 hrs by ELISA	2019	European journal of medicinal chemistry, Mar-15, Volume: 166	Synthesis, antimicrobial and cytotoxic activities, and molecular docking studies of N-arylsulfonylindoles containing an aminoguanidine, a semicarbazide, and a thiosemicarbazide moiety.
AID1601846	Antibacterial activity against Bacillus subtilis CMCC 63501 measured after 24 hrs by ELISA	2019	European journal of medicinal chemistry, Mar-15, Volume: 166	Synthesis, antimicrobial and cytotoxic activities, and molecular docking studies of N-arylsulfonylindoles containing an aminoguanidine, a semicarbazide, and a thiosemicarbazide moiety.
AID432971	Antimicrobial activity against SCCmec type 4 methicillin-resistant Staphylococcus aureus COL MW2-T expressing symporter gene smr1 at 37 degC incubated for 24 hrs by E-test	2008	Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2	Role of a sodium-dependent symporter homologue in the thermosensitivity of beta-lactam antibiotic resistance and cell wall composition in Staphylococcus aureus.
AID576135	Antibacterial activity against 10'4 to 10'5 CFU Enterococcus faecium after 18 hrs by CLSI 2-fold agar dilution method	2010	Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12	In vitro and in vivo activities of LCB01-0371, a new oxazolidinone.
AID501207	Antimicrobial activity against Escherichia coli 389 assessed as hazy zone of inhibition at 30 ug after 18 hrs by agar diffusion method	2009	Journal of natural products, Oct, Volume: 72, Issue:10	Norselic acids A-E, highly oxidized anti-infective steroids that deter mesograzer predation, from the Antarctic sponge Crella sp.
AID581654	Antibacterial activity against Staphylococcus aureus SCV isolated from cystic fibrosis patient at pH 7.4 after 48 hrs by broth microdilution method in absence of thymidine	2009	Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4	Intracellular activity of antibiotics in a model of human THP-1 macrophages infected by a Staphylococcus aureus small-colony variant strain isolated from a cystic fibrosis patient: pharmacodynamic evaluation and comparison with isogenic normal-phenotype a
AID693706	Antibacterial activity against Staphylococcus aureus RN4220 after 20 hrs by two fold serial dilution assay	2012	European journal of medicinal chemistry, Dec, Volume: 58	Synthesis and antibacterial activity of novel 1,3-diphenyl-1H-pyrazoles functionalized with phenylalanine-derived rhodanines.
AID574544	Activity of Quorum sensing agr in community-associated methicillin-resistant Staphylococcus aureus USA300 assessed as PSMbeta expression after 8 hrs by qRT-PCR	2010	Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11	Subinhibitory concentrations of protein synthesis-inhibiting antibiotics promote increased expression of the agr virulence regulator and production of phenol-soluble modulin cytolysins in community-associated methicillin-resistant Staphylococcus aureus.
AID584299	Antibacterial activity against mecA-negative Staphylococcus fleurettii SFMN01 by agar dilution method	2010	Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10	Origin and molecular evolution of the determinant of methicillin resistance in staphylococci.
AID1827241	Antibacterial activity against methicillin-resistant Staphylococcus aureus USA300 harboring stk1 deletion mutant co-transfected with a plasmid bearing stk1 assessed as inhibition of bacterial growth after 18 hrs in presence of oxacillin by CLSI protocol b	2022	ACS medicinal chemistry letters, Mar-10, Volume: 13, Issue:3	Identification and Evaluation of Brominated Carbazoles as a Novel Antibiotic Adjuvant Scaffold in MRSA.
AID576132	Antibacterial activity against 10'4 to 10'5 CFU Haemophilus influenzae after 18 hrs by CLSI 2-fold agar dilution method	2010	Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12	In vitro and in vivo activities of LCB01-0371, a new oxazolidinone.
AID285360	Increase in Panton-Valentine leukocidin level in community acquired methicillin-resistant Staphylococcus aureus HT20030203 in CYY medium	2007	Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4	Effect of antibiotics on Staphylococcus aureus producing Panton-Valentine leukocidin.
AID609225	Antibacterial activity against 10'5 CFU/mL quinolone-resistant Staphylococcus aureus CCARM 3505 assessed as inhibition of bacterial growth after 24 hrs by microtiter enzyme-linked immunosorbent assay	2011	European journal of medicinal chemistry, Aug, Volume: 46, Issue:8	Synthesis of new chalcone derivatives bearing 2,4-thiazolidinedione and benzoic acid moieties as potential anti-bacterial agents.
AID285927	Antimicrobial activity against methicillin-resistant Staphylococcus aureus ATCC 43300 in human monocyte-derived macrophages at 5 ug/ml assessed as bacterial viability after 2 hrs	2007	Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4	Antimicrobial activities of daptomycin, vancomycin, and oxacillin in human monocytes and of daptomycin in combination with gentamicin and/or rifampin in human monocytes and in broth against Staphylococcus aureus.
AID1079945	Animal toxicity known. [column 'TOXIC' in source]
AID1503229	Antibacterial activity against methicillin-resistant Staphylococcus aureus isolate OM481 after 24 hrs by liquid dilution method	2017	Journal of natural products, 10-27, Volume: 80, Issue:10	Structures and Antibacterial Properties of Isorugosins H-J, Oligomeric Ellagitannins from Liquidambar formosana with Characteristic Bridging Groups between Sugar Moieties.
AID1870159	Antibacterial activity against wild type Staphylococcus aureus 78/CF assessed as reduction in microbial growth incubated for 24 hrs by microdilution assay	2022	Journal of medicinal chemistry, 07-28, Volume: 65, Issue:14	LEGO-Lipophosphonoxins: A Novel Approach in Designing Membrane Targeting Antimicrobials.
AID404937	Antibacterial activity against methicillin-susceptible coagulase-negative Staphylococcus sp. by CLSI dilution method	2007	Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7	In vitro activities of CG400549, a novel FabI inhibitor, against recently isolated clinical staphylococcal strains in Korea.
AID1242576	Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC 43300 assessed as change in bacterial surface at 2 ug/ml after 4 hrs by scanning electron microscopic analysis	2015	ACS medicinal chemistry letters, Jul-09, Volume: 6, Issue:7	Triazole-Linked Glycolipids Enhance the Susceptibility of MRSA to β-Lactam Antibiotics.
AID511303	Antibacterial activity against ciprofloxacin susceptible and methicillin resistant Staphylococcus aureus by broth dilution method	2010	Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3	Comparative in vitro activities of nemonoxacin (TG-873870), a novel nonfluorinated quinolone, and other quinolones against clinical isolates.
AID531579	Antibacterial activity against Micrococcus spp. obtained from complicated skin and skin structure infections by agar dilution method	2008	Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9	In vitro activity of ceftobiprole against pathogens from two phase 3 clinical trials of complicated skin and skin structure infections.
AID750318	Antibacterial activity against Staphylococcus aureus isolate C7 derived from naso-pharynx assessed as growth inhibition after 18 hrs by broth microdilution method	2013	European journal of medicinal chemistry, Jun, Volume: 64	Synthesis and evaluation of antimicrobial activity of hydrazones derived from 3-oxido-1H-imidazole-4-carbohydrazides.
AID432979	Antimicrobial activity against SCCmec type 1 methicillin-resistant Staphylococcus aureus COL 319-T1 expressing symporter gene smr1 at 37 degC incubated for 24 hrs by E-test	2008	Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2	Role of a sodium-dependent symporter homologue in the thermosensitivity of beta-lactam antibiotic resistance and cell wall composition in Staphylococcus aureus.
AID530766	Induction of PtcaA::lacZ gene expression in Staphylococcus aureus SH1000 at 8 ug/ml after 2 hrs by beta-galactosidase reporter gene assay relative to untreated control	2008	Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8	Staphylococcus aureus cell wall stress stimulon gene-lacZ fusion strains: potential for use in screening for cell wall-active antimicrobials.
AID576326	Antibacterial activity against 10'4 to 10'5 CFU methicillin-susceptible Staphylococcus aureus after 18 hrs by CLSI 2-fold agar dilution method	2010	Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12	In vitro and in vivo activities of LCB01-0371, a new oxazolidinone.
AID404936	Antibacterial activity against methicillin-resistant coagulase-negative Staphylococcus sp. by CLSI dilution method	2007	Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7	In vitro activities of CG400549, a novel FabI inhibitor, against recently isolated clinical staphylococcal strains in Korea.
AID559047	Antibacterial activity against ciprofloxacin-susceptible and methicillin-resistant Staphylococcus epidermidis by CLSI M100-S18 method	2009	Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8	Besifloxacin, a novel fluoroquinolone, has broad-spectrum in vitro activity against aerobic and anaerobic bacteria.
AID1304324	Antibacterial activity against methicillin-susceptible Staphylococcus aureus ATCC 29213 assessed as growth inhibition after 18 to 20 hrs by microdilution assay	2016	Bioorganic & medicinal chemistry letters, 07-01, Volume: 26, Issue:13	Caged xanthones: Potent inhibitors of global predominant MRSA USA300.
AID565003	Bactericidal activity against methicillin-susceptible coagulase-negative Staphylococcus hominis after 24 hrs by plate counting method	2009	Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10	In vitro activities of panduratin A against clinical Staphylococcus strains.
AID693709	Antibacterial activity against methicillin-resistant Staphylococcus aureus CCARM 3167 after 20 hrs by two fold serial dilution assay	2012	European journal of medicinal chemistry, Dec, Volume: 58	Synthesis and antibacterial activity of novel 1,3-diphenyl-1H-pyrazoles functionalized with phenylalanine-derived rhodanines.
AID531555	Antibacterial activity against coagulase-negative Staphylococcus haemolyticus obtained from complicated skin and skin structure infections by agar dilution method	2008	Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9	In vitro activity of ceftobiprole against pathogens from two phase 3 clinical trials of complicated skin and skin structure infections.
AID584297	Antibacterial activity against methicillin-resistant mecA-positive Staphylococcus fleurettii SFMP07 by agar dilution method	2010	Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10	Origin and molecular evolution of the determinant of methicillin resistance in staphylococci.
AID1651739	Antibacterial activity against Enterococcus faecium MB3 after 24 hrs by microdilution assay	2020	Journal of natural products, 04-24, Volume: 83, Issue:4	Antibacterial and ATP Synthesis Modulating Compounds from
AID581668	Antibacterial activity against revertant Staphylococcus aureus infected in human THP-1 cells assessed as log reduction of extracellular CFU level after 24 hrs	2009	Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4	Intracellular activity of antibiotics in a model of human THP-1 macrophages infected by a Staphylococcus aureus small-colony variant strain isolated from a cystic fibrosis patient: pharmacodynamic evaluation and comparison with isogenic normal-phenotype a
AID1691361	Antimicrobial activity against multidrug-resistant Pseudomonas aeruginosa CCARM 2095 assessed as reduction in microbial growth incubated for 18 to 24 hrs by broth microdilution method	2020	European journal of medicinal chemistry, May-01, Volume: 193	Antibacterial AZT derivative regulates metastasis of breast cancer cells.
AID1870149	Antibacterial activity against wild type Staphylococcus aureus 4504/A assessed as reduction in microbial growth incubated for 24 hrs by microdilution assay	2022	Journal of medicinal chemistry, 07-28, Volume: 65, Issue:14	LEGO-Lipophosphonoxins: A Novel Approach in Designing Membrane Targeting Antimicrobials.
AID625290	Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for liver fatty	2011	PLoS computational biology, Dec, Volume: 7, Issue:12	Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
AID560519	Antimicrobial activity against SCCmec type III vancomycin-intermediate Staphylococcus aureus isolate zj07028 by agar dilution method	2009	Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9	Prevalence and characterization of heterogeneous vancomycin-intermediate Staphylococcus aureus isolates from 14 cities in China.
AID544611	Antibacterial activity against Staphylococcus aureus isolate 6083 assessed as reduction in bacterial count at 20 ug/ml after 24 hrs by time-kill assay	2008	Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11	In vitro and in vivo evaluations of oxacillin efficiency against mecA-positive oxacillin-susceptible Staphylococcus aureus.
AID1079941	Liver damage due to vascular disease: peliosis hepatitis, hepatic veno-occlusive disease, Budd-Chiari syndrome. Value is number of references indexed. [column 'VASC' in source]
AID1242583	Antibacterial activity against methicillin-resistant Staphylococcus aureus R49 clinical isolate after 20 to 24 hrs by CLSI method	2015	ACS medicinal chemistry letters, Jul-09, Volume: 6, Issue:7	Triazole-Linked Glycolipids Enhance the Susceptibility of MRSA to β-Lactam Antibiotics.
AID559048	Antibacterial activity against non-ciprofloxacin-susceptible and methicillin-susceptible Staphylococcus epidermidis by CLSI M100-S18 method	2009	Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8	Besifloxacin, a novel fluoroquinolone, has broad-spectrum in vitro activity against aerobic and anaerobic bacteria.
AID629348	Antifungal activity against Aspergillus niger assessed as zone of inhibition at 0.01 mg/mL after 48 to 72 hrs by stiff-plate agar-diffusion method	2011	European journal of medicinal chemistry, Dec, Volume: 46, Issue:12	Synthesis and biological activity of novel N-cycloalkyl-(cycloalkylaryl)-2-[(3-R-2-oxo-2H-[1,2,4]triazino[2,3-c]quinazoline-6-yl)thio]acetamides.
AID1254080	Antibacterial activity against quinolone-resistant Staphylococcus aureus CCARM 3519 after 24 hrs by two-fold serial dilution method	2015	Bioorganic & medicinal chemistry letters, Nov-15, Volume: 25, Issue:22	Synthesis and biological evaluation of 1,3-diaryl pyrazole derivatives as potential antibacterial and anti-inflammatory agents.
AID573385	Antibacterial activity against beta lactamase-positive Moraxella catarrhalis by CLSI M7-A7 broth microdilution method	2008	Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9	In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States.
AID1079932	Highest frequency of moderate liver toxicity observed during clinical trials, expressed as a percentage. [column '% BIOL' in source]
AID432977	Antimicrobial activity against SCCmec type 1 methicillin-resistant Staphylococcus aureus COL 319 expressing symporter gene smr1 at 37 degC incubated for 24 hrs by E-test	2008	Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2	Role of a sodium-dependent symporter homologue in the thermosensitivity of beta-lactam antibiotic resistance and cell wall composition in Staphylococcus aureus.
AID509068	Induction of mecA gene expression in beta-lactamase positive SCCmec type 5 methicillin-resistant Staphylococcus aureus isolate 12868 at MIC after 1 hr by multiplex PCR method	2010	Antimicrobial agents and chemotherapy, Feb, Volume: 54, Issue:2	Effects of ceftobiprole and oxacillin on mecA expression in methicillin-resistant Staphylococcus aureus clinical isolates.
AID581664	Antibacterial activity against Staphylococcus aureus SCV isolated from cystic fibrosis patient infected in human THP-1 cells assessed as log reduction of intracellular CFU level per mg of protein after 24 hrs	2009	Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4	Intracellular activity of antibiotics in a model of human THP-1 macrophages infected by a Staphylococcus aureus small-colony variant strain isolated from a cystic fibrosis patient: pharmacodynamic evaluation and comparison with isogenic normal-phenotype a
AID560515	Antimicrobial activity against SCCmec type III vancomycin-intermediate Staphylococcus aureus isolate 13b16 by agar dilution method	2009	Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9	Prevalence and characterization of heterogeneous vancomycin-intermediate Staphylococcus aureus isolates from 14 cities in China.
AID369437	Antimicrobial activity against methicillin-susceptible coagulase-negative Staphylococcus after 20 to 24 hrs by broth microdilution method	2007	Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9	In vitro activity of telavancin against gram-positive clinical isolates recently obtained in Europe.
AID565007	Bactericidal activity against methicillin-susceptible coagulase-negative Staphylococcus epidermidis after 24 hrs by plate counting method	2009	Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10	In vitro activities of panduratin A against clinical Staphylococcus strains.
AID509060	Antibacterial activity against beta-lactamase positive SCCmec type 2 methicillin-resistant Staphylococcus aureus isolate 17256 by broth microdilution method	2010	Antimicrobial agents and chemotherapy, Feb, Volume: 54, Issue:2	Effects of ceftobiprole and oxacillin on mecA expression in methicillin-resistant Staphylococcus aureus clinical isolates.
AID285918	Antimicrobial activity against methicillin-resistant Staphylococcus aureus ATCC 43300 in human monocyte-derived macrophages at 0.25 ug/ml assessed as bacterial viability after 2 hrs	2007	Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4	Antimicrobial activities of daptomycin, vancomycin, and oxacillin in human monocytes and of daptomycin in combination with gentamicin and/or rifampin in human monocytes and in broth against Staphylococcus aureus.
AID660262	Ratio of MIC for wild type Escherichia coli TG1 to MIC for acrB-deficient Escherichia coli KAM3 by two-fold serial dilution method	2012	European journal of medicinal chemistry, Jun, Volume: 52	Computational analysis of structure-based interactions and ligand properties can predict efflux effects on antibiotics.
AID681114	TP_TRANSPORTER: inhibition of Gly-Sar uptake (pH6.0) in SKPT cells	2005	European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, Jan, Volume: 59, Issue:1	Interaction of 31 beta-lactam antibiotics with the H+/peptide symporter PEPT2: analysis of affinity constants and comparison with PEPT1.
AID520726	Activity of Escherichia coli TOP10 beta-lactamase OXA-58 assessed per mg of protein at 100 uM	2008	Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5	Carbapenem-resistant Acinetobacter baumannii isolates from Tunisia producing the OXA-58-like carbapenem-hydrolyzing oxacillinase OXA-97.
AID1870147	Antibacterial activity against wild type Staphylococcus aureus 4482/A assessed as reduction in microbial growth incubated for 24 hrs by microdilution assay	2022	Journal of medicinal chemistry, 07-28, Volume: 65, Issue:14	LEGO-Lipophosphonoxins: A Novel Approach in Designing Membrane Targeting Antimicrobials.
AID373190	Induction of VraSR-dependent tcaA gene expression in Staphylococcus aureus KVR expressing N315 delta-vraSr mutant at 2 ug/mL after 30 mins by Northern blot analysis	2007	Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11	Functional characterization of TcaA: minimal requirement for teicoplanin susceptibility and role in Caenorhabditis elegans virulence.
AID545958	Antimicrobial activity against methicillin-resistant Staphylococcus aureus 16671 by broth dilution method	2010	Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8	Identification of a novel transposon (Tn6072) and a truncated staphylococcal cassette chromosome mec element in methicillin-resistant Staphylococcus aureus ST239.
AID278914	Antibacterial activity against methicillin-resistant coagulase-negative staphylococci	2007	Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1	In vitro antibacterial activity of the pyrrolopyrazolyl-substituted oxazolidinone RWJ-416457.
AID530754	Induction of PsgtB::lacZ gene expression in Staphylococcus aureus SH1000 at 1.2 ug/ml after 2 hrs by beta-galactosidase reporter gene assay relative to untreated control	2008	Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8	Staphylococcus aureus cell wall stress stimulon gene-lacZ fusion strains: potential for use in screening for cell wall-active antimicrobials.
AID637224	Antibacterial activity against Escherichia coli CCARM 1356 after 20 hrs by twofold serial dilution technique	2012	European journal of medicinal chemistry, Feb, Volume: 48	Synthesis of novel 1,3-diaryl pyrazole derivatives bearing rhodanine-3-fatty acid moieties as potential antibacterial agents.
AID1567132	Antimicrobial activity against CA-methicillin-resistant Staphylococcus aureus W47 ST30 incubated for 20 hrs by microdilution method	2019	European journal of medicinal chemistry, Sep-15, Volume: 178	Design, synthesis and biological evaluation of antimicrobial diarylimine and -amine compounds targeting the interaction between the bacterial NusB and NusE proteins.
AID546183	Antimicrobial activity against methicillin-resistant Staphylococcus aureus 16696 by broth dilution method	2010	Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8	Identification of a novel transposon (Tn6072) and a truncated staphylococcal cassette chromosome mec element in methicillin-resistant Staphylococcus aureus ST239.
AID1245570	Antibacterial activity against Staphylococcus aureus ATCC 25923 after 24 hrs by broth microdilution method	2015	Bioorganic & medicinal chemistry, Oct-01, Volume: 23, Issue:19	Deprotometalation-iodolysis and computed CH acidity of 1,2,3- and 1,2,4-triazoles. Application to the synthesis of resveratrol analogues.
AID1567130	Antimicrobial activity against Staphylococcus aureus ATCC BAA44 incubated for 20 hrs by microdilution method	2019	European journal of medicinal chemistry, Sep-15, Volume: 178	Design, synthesis and biological evaluation of antimicrobial diarylimine and -amine compounds targeting the interaction between the bacterial NusB and NusE proteins.
AID1853603	Antibacterial activity against Enterococcus faecalis clinical isolate 1088051 assessed as inhibition of bacterial growth by CLSI protocol based broth microdilution method	2021	RSC medicinal chemistry, Oct-20, Volume: 12, Issue:10	Design, synthesis, and antibacterial activity of
AID542619	Antimicrobial activity against streptomycin- resistant Streptococcus pneumoniae R6 harboring PBP2x2349 mutant gene and Janus disruption at PBP1a after 48 hrs by agar dilution method	2009	Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3	An important site in PBP2x of penicillin-resistant clinical isolates of Streptococcus pneumoniae: mutational analysis of Thr338.
AID1759641	Antimicrobial activity against vancomycin-resistant Enterococcus faecium clinical isolate 1091563 by CLSI-based broth microdilution assay	2021	European journal of medicinal chemistry, Jul-05, Volume: 219	4-4-(Anilinomethyl)-3-[4-(trifluoromethyl)phenyl]-1H-pyrazol-1-ylbenzoic acid derivatives as potent anti-gram-positive bacterial agents.
AID750302	Bactericidal activity against Staphylococcus aureus isolate F1 derived from ulcer and furuncle after 18 hrs by broth microdilution method	2013	European journal of medicinal chemistry, Jun, Volume: 64	Synthesis and evaluation of antimicrobial activity of hydrazones derived from 3-oxido-1H-imidazole-4-carbohydrazides.
AID564814	Antimicrobial activity against methicillin-resistant coagulase-negative Staphylococcus epidermidis assessed as resistant isolates after 24 hrs by broth microdilution method	2009	Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10	In vitro activities of panduratin A against clinical Staphylococcus strains.
AID285937	Antimicrobial activity against methicillin-susceptible Staphylococcus aureus ATCC 29213 in human monocyte-derived macrophages at 2.5 ug/ml assessed as bacterial viability after 4 hrs	2007	Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4	Antimicrobial activities of daptomycin, vancomycin, and oxacillin in human monocytes and of daptomycin in combination with gentamicin and/or rifampin in human monocytes and in broth against Staphylococcus aureus.
AID396032	Antibacterial activity against drug-resistant AcrAB-TolC efflux pump deficient Enterobacter cloacae EcdeltaacrA isolate expressing pAP3 plasmid containing Enterobacter aerogenes acrR gene by Etest	2007	Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9	Cloning, nucleotide sequencing, and analysis of the AcrAB-TolC efflux pump of Enterobacter cloacae and determination of its involvement in antibiotic resistance in a clinical isolate.
AID285350	Antibacterial activity against community acquired methicillin-resistant Staphylococcus aureus HT20040332 in CCY media	2007	Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4	Effect of antibiotics on Staphylococcus aureus producing Panton-Valentine leukocidin.
AID1567131	Antimicrobial activity against Staphylococcus aureus HA W231 ST45 incubated for 20 hrs by microdilution method	2019	European journal of medicinal chemistry, Sep-15, Volume: 178	Design, synthesis and biological evaluation of antimicrobial diarylimine and -amine compounds targeting the interaction between the bacterial NusB and NusE proteins.
AID431115	Antibacterial activity against graSR gene knockout heterogeneous vancomycin-intermediate Staphylococcus aureus Mu3 after 48 hrs by agar dilution method	2008	Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1	Mutated response regulator graR is responsible for phenotypic conversion of Staphylococcus aureus from heterogeneous vancomycin-intermediate resistance to vancomycin-intermediate resistance.
AID564817	Bactericidal activity against methicillin-resistant coagulase-negative Staphylococcus hominis after 24 hrs by plate counting method	2009	Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10	In vitro activities of panduratin A against clinical Staphylococcus strains.
AID66750	Activity of the VanS/VanR TCS in Enterococcus faecalis OC3364; Not Tested	1998	Journal of medicinal chemistry, Jul-30, Volume: 41, Issue:16	Substituted salicylanilides as inhibitors of two-component regulatory systems in bacteria.
AID559505	Antibacterial activity against Staphylococcus hominis assessed as percent susceptible isolates by CLSI M100-S18 method	2009	Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8	Besifloxacin, a novel fluoroquinolone, has broad-spectrum in vitro activity against aerobic and anaerobic bacteria.
AID1517082	Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC 19952 assessed as reduction in bacterial growth incubated for 24 hrs by serial dilution method	2019	European journal of medicinal chemistry, Dec-01, Volume: 183	Two optimized antimicrobial peptides with therapeutic potential for clinical antibiotic-resistant Staphylococcus aureus.
AID1601852	Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC 33591 measured after 24 hrs by ELISA	2019	European journal of medicinal chemistry, Mar-15, Volume: 166	Synthesis, antimicrobial and cytotoxic activities, and molecular docking studies of N-arylsulfonylindoles containing an aminoguanidine, a semicarbazide, and a thiosemicarbazide moiety.
AID405480	Effect on blaZ gene expression in oxacillin-dependent methicillin-resistant Staphylococcus aureus 2884D isolate at 0.5 ug/ml by RT-PCR	2007	Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7	Identification and phenotypic characterization of a beta-lactam-dependent, methicillin-resistant Staphylococcus aureus strain.
AID1559374	Antibacterial activity against wild type Klebsiella pneumoniae CI 09 after 16 to 20 hrs by CLSI-based microbroth dilution method	2020	Journal of medicinal chemistry, 03-26, Volume: 63, Issue:6	Discovery of Taniborbactam (VNRX-5133): A Broad-Spectrum Serine- and Metallo-β-lactamase Inhibitor for Carbapenem-Resistant Bacterial Infections.
AID432983	Antimicrobial activity against SCCmec type 1 methicillin-resistant Staphylococcus aureus COL 404-T3 expressing symporter gene smr1 at 37 degC incubated for 24 hrs by E-test	2008	Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2	Role of a sodium-dependent symporter homologue in the thermosensitivity of beta-lactam antibiotic resistance and cell wall composition in Staphylococcus aureus.
AID1438605	Antibacterial activity against Staphylococcus aureus ATCC 29213 after 18 hrs by broth microdilution assay	2017	European journal of medicinal chemistry, Mar-10, Volume: 128	Synthesis, surfactant properties and antimicrobial activities of methyl glycopyranoside ethers.
AID383180	Antimicrobial activity against methicillin-resistant Staphylococcus aureus ATCC 700788	2008	Journal of natural products, Apr, Volume: 71, Issue:4	Sesterterpenoids from the sponge Sarcotragus sp.
AID1902630	Antibacterial activity against Methicillin-drug resistant Staphylococcus aureus C0621 incubated for 18 hrs by by disc diffusion method	2022	ACS medicinal chemistry letters, Feb-10, Volume: 13, Issue:2	Antibacterial Activity of Metergoline Analogues: Revisiting the Ergot Alkaloid Scaffold for Antibiotic Discovery.
AID1827240	Antibacterial activity against methicillin-resistant Staphylococcus aureus USA300 harboring stk1 deletion mutant assessed as inhibition of bacterial growth after 18 hrs in presence of oxacillin by CLSI protocol based broth microdilution assay	2022	ACS medicinal chemistry letters, Mar-10, Volume: 13, Issue:3	Identification and Evaluation of Brominated Carbazoles as a Novel Antibiotic Adjuvant Scaffold in MRSA.
AID531556	Antibacterial activity against coagulase-negative Staphylococcus lugdunensis obtained from complicated skin and skin structure infections by agar dilution method	2008	Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9	In vitro activity of ceftobiprole against pathogens from two phase 3 clinical trials of complicated skin and skin structure infections.
AID1651724	Antibacterial activity against Methicillin-resistant Staphylococcus aureus MB188 after 24 hrs by microdilution assay	2020	Journal of natural products, 04-24, Volume: 83, Issue:4	Antibacterial and ATP Synthesis Modulating Compounds from
AID564819	Antimicrobial activity against methicillin-resistant coagulase-negative Staphylococcus hominis assessed as susceptible isolates after 24 hrs by broth microdilution method	2009	Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10	In vitro activities of panduratin A against clinical Staphylococcus strains.
AID529117	Antimicrobial activity against methicillin-resistant Staphylococcus aureus HAR22 by Etest	2008	Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8	Comparative study of the susceptibilities of major epidemic clones of methicillin-resistant Staphylococcus aureus to oxacillin and to the new broad-spectrum cephalosporin ceftobiprole.
AID425863	Antimicrobial activity against Carnobacterium divergens CIP101029 at 0.5 McFarland inoculum size by E-test	2008	Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2	Genetic and biochemical characterization of CAD-1, a chromosomally encoded new class A penicillinase from Carnobacterium divergens.
AID1504825	Antibacterial activity against beta-lactamase producing methicillin-resistant Staphylococcus aureus ATCC 11632 after 24 hrs by broth microdilution method	2017	Journal of natural products, 12-22, Volume: 80, Issue:12	Sulfur-Containing Aristoloxazines and Other Constituents of the Roots of Aristolochia orbicularis.
AID1246294	Resistance index, ratio of MIC for methicillin-resistant Staphylococcus aureus HEMSA to MIC for Staphylococcus aureus ATCC 25923	2015	European journal of medicinal chemistry, Aug-28, Volume: 101	Imidazolidine-4-one derivatives in the search for novel chemosensitizers of Staphylococcus aureus MRSA: synthesis, biological evaluation and molecular modeling studies.
AID1853605	Antibacterial activity against Enterococcus faecalis clinical isolate 1091720 assessed as inhibition of bacterial growth by CLSI protocol based broth microdilution method	2021	RSC medicinal chemistry, Oct-20, Volume: 12, Issue:10	Design, synthesis, and antibacterial activity of
AID529295	Inhibition of methicillin-resistant Staphylococcus aureus 67-O PBP2a by competitive assay	2008	Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8	Comparative study of the susceptibilities of major epidemic clones of methicillin-resistant Staphylococcus aureus to oxacillin and to the new broad-spectrum cephalosporin ceftobiprole.
AID1304337	Bactericidal activity against methicillin-susceptible Staphylococcus aureus ATCC 29213 after 18 to 20 hrs	2016	Bioorganic & medicinal chemistry letters, 07-01, Volume: 26, Issue:13	Caged xanthones: Potent inhibitors of global predominant MRSA USA300.
AID520423	Antibacterial activity against methicillin-resistant mecA-positive Staphylococcus saprophyticus isolate TSU18 isolated from genitourinary tracts of acute cystitis patient after 24 hrs at 35 degC by agar dilution method	2008	Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6	Methicillin-resistant Staphylococcus saprophyticus isolates carrying staphylococcal cassette chromosome mec have emerged in urogenital tract infections.
AID1853470	Antibacterial activity against methicillin-resistant Staphylococcus aureus ST1312 (ARLG 1649) assessed as bacterial growth inhibition incubated for 18 to 20 hrs by CLSI based broth microdilution assay	2021	RSC medicinal chemistry, Nov-17, Volume: 12, Issue:11	SF
AID362542	Antibacterial activity against macrolide-resistant Staphylococcus aureus RN4220 after 18 hrs	2008	Journal of natural products, Aug, Volume: 71, Issue:8	Antibacterial cannabinoids from Cannabis sativa: a structure-activity study.
AID564822	Bactericidal activity against methicillin-resistant Staphylococcus aureus after 24 hrs by plate counting method	2009	Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10	In vitro activities of panduratin A against clinical Staphylococcus strains.
AID545947	Antimicrobial activity against methicillin-resistant Staphylococcus aureus 16684 by broth dilution method	2010	Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8	Identification of a novel transposon (Tn6072) and a truncated staphylococcal cassette chromosome mec element in methicillin-resistant Staphylococcus aureus ST239.
AID571763	Antimicrobial activity against Escherichia coli K-12 3-AG300 harboring AcrB-F628F mutant gene	2009	Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1	Site-directed mutagenesis reveals amino acid residues in the Escherichia coli RND efflux pump AcrB that confer macrolide resistance.
AID509049	Antibacterial activity against beta-lactamase positive SCCmec type 3 methicillin-resistant Staphylococcus aureus isolate 12662 by broth microdilution method	2010	Antimicrobial agents and chemotherapy, Feb, Volume: 54, Issue:2	Effects of ceftobiprole and oxacillin on mecA expression in methicillin-resistant Staphylococcus aureus clinical isolates.
AID1567138	Antimicrobial activity against CA-methicillin-resistant Staphylococcus aureus W48 ST217 incubated for 20 hrs by microdilution method	2019	European journal of medicinal chemistry, Sep-15, Volume: 178	Design, synthesis and biological evaluation of antimicrobial diarylimine and -amine compounds targeting the interaction between the bacterial NusB and NusE proteins.
AID1559376	Antibacterial activity against Klebsiella pneumoniae A-1797 expressing KPC-2/VIM-4/CMY-4 after 16 to 20 hrs by CLSI-based microbroth dilution method	2020	Journal of medicinal chemistry, 03-26, Volume: 63, Issue:6	Discovery of Taniborbactam (VNRX-5133): A Broad-Spectrum Serine- and Metallo-β-lactamase Inhibitor for Carbapenem-Resistant Bacterial Infections.
AID533927	Antimicrobial activity against Staphylococcus aureus 1651 harboring G2576U mutation in peptidyl transferase centre by broth microdilution method	2008	Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12	In vitro activity of TR-700, the antibacterial moiety of the prodrug TR-701, against linezolid-resistant strains.
AID761559	Antibacterial activity against Micrococcus luteus ATCC 9341 by M07-A9 CLSI method	2013	Bioorganic & medicinal chemistry letters, Aug-01, Volume: 23, Issue:15	Synthesis and antimicrobial activity of imidazole and pyridine appended cholestane-based conjugates.
AID523269	Binding affinity to Escherichia coli isolate HN1157 AcrAB-TolC efflux transporter	2010	Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5	Kinetic parameters of efflux of penicillins by the multidrug efflux transporter AcrAB-TolC of Escherichia coli.
AID542626	Antimicrobial activity against Streptococcus pneumoniae R6 harboring PBP2x T338G and PBP1a2349 mutant gene and aad9 disruption in CiaR gene after 48 hrs by agar dilution method	2009	Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3	An important site in PBP2x of penicillin-resistant clinical isolates of Streptococcus pneumoniae: mutational analysis of Thr338.
AID542629	Antimicrobial activity against streptomycin-resistant Streptococcus pneumoniae R6 harboring PBP2x T338G mutant gene, Janus disruption at PBP1a and aad9 disruption in CiaR gene after 48 hrs by agar dilution method	2009	Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3	An important site in PBP2x of penicillin-resistant clinical isolates of Streptococcus pneumoniae: mutational analysis of Thr338.
AID765063	Antimicrobial activity against methicillin-sensitive Staphylococcus aureus 8325-4 by broth microdilution method	2013	Bioorganic & medicinal chemistry letters, Sep-01, Volume: 23, Issue:17	Antibacterial activity of quinoxalines, quinazolines, and 1,5-naphthyridines.
AID1242580	Antibacterial activity against methicillin-resistant Staphylococcus aureus R15 clinical isolate after 20 to 24 hrs by CLSI method	2015	ACS medicinal chemistry letters, Jul-09, Volume: 6, Issue:7	Triazole-Linked Glycolipids Enhance the Susceptibility of MRSA to β-Lactam Antibiotics.
AID576134	Antibacterial activity against 10'4 to 10'5 CFU vancomycin-resistant Enterococcus after 18 hrs by CLSI 2-fold agar dilution method	2010	Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12	In vitro and in vivo activities of LCB01-0371, a new oxazolidinone.
AID545970	Antimicrobial activity against methicillin-resistant Staphylococcus aureus 16678 by broth dilution method	2010	Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8	Identification of a novel transposon (Tn6072) and a truncated staphylococcal cassette chromosome mec element in methicillin-resistant Staphylococcus aureus ST239.
AID1827138	Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC 43300 assessed as inhibition of bacterial growth after 18 hrs by CLSI protocol based broth microdilution assay	2022	ACS medicinal chemistry letters, Mar-10, Volume: 13, Issue:3	Identification and Evaluation of Brominated Carbazoles as a Novel Antibiotic Adjuvant Scaffold in MRSA.
AID562392	Antimicrobial activity against Staphylococcus haemolyticus clinical isolates assessed as percent susceptible isolates by broth microdilution method	2009	Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11	Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates.
AID520875	Antibacterial activity against methicillin-resistant mecA-positive Staphylococcus saprophyticus isolates isolated from genitourinary tracts of acute cystitis patient after 24 hrs at 35 degC by agar dilution method	2008	Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6	Methicillin-resistant Staphylococcus saprophyticus isolates carrying staphylococcal cassette chromosome mec have emerged in urogenital tract infections.
AID558752	Antibacterial activity against hetero-Methicillin-resistant and tetracycline-resistant Staphylococcus aureus deltaIP by Etest method	2009	Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8	Selection of heterogeneous vancomycin-intermediate Staphylococcus aureus by imipenem.
AID531554	Antibacterial activity against coagulase-negative Staphylococcus epidermidis obtained from complicated skin and skin structure infections by agar dilution method	2008	Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9	In vitro activity of ceftobiprole against pathogens from two phase 3 clinical trials of complicated skin and skin structure infections.
AID1079936	Choleostatic liver toxicity, either proven histopathologically or where the ratio of maximal ALT or AST activity above normal to that of Alkaline Phosphatase is < 2 (see ACUTE). Value is number of references indexed. [column 'CHOLE' in source]
AID559049	Antibacterial activity against Staphylococcus haemolyticus by CLSI M100-S18 method	2009	Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8	Besifloxacin, a novel fluoroquinolone, has broad-spectrum in vitro activity against aerobic and anaerobic bacteria.
AID533935	Antimicrobial activity against linezolid-resistant Staphylococcus aureus 004-737X harboring plasmid borne cfr gene by broth microdilution method	2008	Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12	In vitro activity of TR-700, the antibacterial moiety of the prodrug TR-701, against linezolid-resistant strains.
AID285348	Antibacterial activity against community acquired methicillin-resistant Staphylococcus aureus HT20020488 in CCY medium	2007	Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4	Effect of antibiotics on Staphylococcus aureus producing Panton-Valentine leukocidin.
AID559503	Antibacterial activity against non-ciprofloxacin-susceptible and methicillin-susceptible Staphylococcus epidermidis assessed as percent susceptible isolates by CLSI M100-S18 method	2009	Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8	Besifloxacin, a novel fluoroquinolone, has broad-spectrum in vitro activity against aerobic and anaerobic bacteria.
AID529132	Antimicrobial activity against methicillin-resistant Staphylococcus aureus HPV107 assessed as concentration required for minimum inhibition of oxacillin-resistant subpopulation growth by Etest	2008	Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8	Comparative study of the susceptibilities of major epidemic clones of methicillin-resistant Staphylococcus aureus to oxacillin and to the new broad-spectrum cephalosporin ceftobiprole.
AID565012	Antimicrobial activity against methicillin-susceptible coagulase-negative Staphylococcus simulans after 24 hrs by broth microdilution method	2009	Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10	In vitro activities of panduratin A against clinical Staphylococcus strains.
AID556049	Antimicrobial activity against tetracycline-, glycopepeptide-intermediate-resistant and rsbUVW-sigB operon deficient Staphylococcus aureus NCTC 8325 by broth microdilution method	2009	Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5	Functional characterization of the sigmaB-dependent yabJ-spoVG operon in Staphylococcus aureus: role in methicillin and glycopeptide resistance.
AID429444	Antimicrobial activity against methicillin-resistant Staphylococcus aureus isolate 8	2009	Bioorganic & medicinal chemistry letters, Aug-15, Volume: 19, Issue:16	Isoplatensimycin: Synthesis and biological evaluation.
AID739298	Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC 33591 assessed as growth inhibition by CLSI broth microdilution method	2013	Bioorganic & medicinal chemistry letters, Apr-01, Volume: 23, Issue:7	Substituted 1,6-diphenylnaphthalenes as FtsZ-targeting antibacterial agents.
AID565756	Antimicrobial activity against oxacillin-resistant Staphylococcus epidermidis clinical isolates by broth microdilution method	2009	Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11	Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates.
AID1853609	Antibacterial activity against Enterococcus faecium clinical isolate 1088228 assessed as inhibition of bacterial growth by CLSI protocol based broth microdilution method	2021	RSC medicinal chemistry, Oct-20, Volume: 12, Issue:10	Design, synthesis, and antibacterial activity of
AID750306	Bactericidal activity against Staphylococcus aureus isolate C7 derived from naso-pharynx after 18 hrs by broth microdilution method	2013	European journal of medicinal chemistry, Jun, Volume: 64	Synthesis and evaluation of antimicrobial activity of hydrazones derived from 3-oxido-1H-imidazole-4-carbohydrazides.
AID431107	Antibacterial activity against heterogeneous vancomycin-intermediate Staphylococcus aureus Mu3 after 48 hrs by agar dilution method	2008	Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1	Mutated response regulator graR is responsible for phenotypic conversion of Staphylococcus aureus from heterogeneous vancomycin-intermediate resistance to vancomycin-intermediate resistance.
AID528531	Antimicrobial activity against penicillin-resistant Streptococcus agalactiae B60 by agar dilution method	2008	Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8	First molecular characterization of group B streptococci with reduced penicillin susceptibility.
AID1827256	Upregulation of mecA gene expression in methicillin-resistant Staphylococcus aureus ATCC 43300 by RT-PCR method	2022	ACS medicinal chemistry letters, Mar-10, Volume: 13, Issue:3	Identification and Evaluation of Brominated Carbazoles as a Novel Antibiotic Adjuvant Scaffold in MRSA.
AID356966	Antibacterial activity against vancomycin-resistant Enterococcus faecalis CKU-17 expressing VanB after 24 hrs by broth microdilution method	2002	Journal of natural products, Dec, Volume: 65, Issue:12	Antimicrobial activities of naphthazarins from Arnebia euchroma.
AID750316	Antibacterial activity against Staphylococcus aureus isolate C19 derived from naso-pharynx assessed as growth inhibition after 18 hrs by broth microdilution method	2013	European journal of medicinal chemistry, Jun, Volume: 64	Synthesis and evaluation of antimicrobial activity of hydrazones derived from 3-oxido-1H-imidazole-4-carbohydrazides.
AID529131	Antimicrobial activity against methicillin-resistant Staphylococcus aureus E2125 assessed as concentration required for minimum inhibition of oxacillin-resistant subpopulation growth by Etest	2008	Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8	Comparative study of the susceptibilities of major epidemic clones of methicillin-resistant Staphylococcus aureus to oxacillin and to the new broad-spectrum cephalosporin ceftobiprole.
AID509071	Induction of mecA gene expression in beta-lactamase positive SCCmec type 2 methicillin-resistant Staphylococcus aureus isolate 15855 at MIC after 1 hr by multiplex PCR method	2010	Antimicrobial agents and chemotherapy, Feb, Volume: 54, Issue:2	Effects of ceftobiprole and oxacillin on mecA expression in methicillin-resistant Staphylococcus aureus clinical isolates.
AID405592	Increase in SA2098 N315 gene expression in oxacillin-dependent methicillin-resistant Staphylococcus aureus 2884D isolate at 0.5 ug/ml by microarray-based transcriptional profiling relative to control	2007	Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7	Identification and phenotypic characterization of a beta-lactam-dependent, methicillin-resistant Staphylococcus aureus strain.
AID531560	Antibacterial activity against coagulase-negative Staphylococcus cohnii obtained from complicated skin and skin structure infections by agar dilution method	2008	Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9	In vitro activity of ceftobiprole against pathogens from two phase 3 clinical trials of complicated skin and skin structure infections.
AID405602	Increase in dps gene expression in oxacillin-dependent methicillin-resistant Staphylococcus aureus 2884D isolate at 0.5 ug/ml by microarray-based transcriptional profiling relative to control	2007	Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7	Identification and phenotypic characterization of a beta-lactam-dependent, methicillin-resistant Staphylococcus aureus strain.
AID562604	Antimicrobial activity against oxacillin-susceptible Staphylococcus aureus clinical isolates assessed as resistant isolates by broth microdilution method	2009	Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11	Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates.
AID1242590	Antibacterial activity against methicillin-resistant Staphylococcus aureus R313 clinical isolate after 20 to 24 hrs by CLSI method	2015	ACS medicinal chemistry letters, Jul-09, Volume: 6, Issue:7	Triazole-Linked Glycolipids Enhance the Susceptibility of MRSA to β-Lactam Antibiotics.
AID573155	Antibacterial activity against vancomycin-resistant Enterococcus faecium by CLSI M7-A7 broth microdilution method	2008	Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9	In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States.
AID238858	Binding affinity against membrane transport protein PEPT1 in human Caco-2 cells	2005	Journal of medicinal chemistry, Jun-30, Volume: 48, Issue:13	Three-dimensional quantitative structure-activity relationship analyses of beta-lactam antibiotics and tripeptides as substrates of the mammalian H+/peptide cotransporter PEPT1.
AID576325	Antibacterial activity against 10'4 to 10'5 CFU methicillin-resistant Staphylococcus aureus after 18 hrs by CLSI 2-fold agar dilution method	2010	Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12	In vitro and in vivo activities of LCB01-0371, a new oxazolidinone.
AID1879317	Antibacterial activity against Staphylococcus aureus ATCC 25923 assessed as inhibition of bacterial growth measured after repeated 30 day serial passage treatment by broth microdilution method	2022	Bioorganic & medicinal chemistry, 03-01, Volume: 57	Synthesis and biological evaluation of tetrahydroisoquinoline-derived antibacterial compounds.
AID519633	Ratio of Kcat to Km for Brachyspira pilosicoli beta-lactamase OXA-63 expressed in Escherichia coli BL21 (DE3) assessed as compound hydrolysis by spectrophotometry	2008	Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4	Genetic and biochemical characterization of OXA-63, a new class D beta-lactamase from Brachyspira pilosicoli BM4442.
AID509072	Induction of mecA gene expression in beta-lactamase positive SCCmec type 1 methicillin-resistant Staphylococcus aureus isolate 11631 at MIC after 1 hr by multiplex PCR method	2010	Antimicrobial agents and chemotherapy, Feb, Volume: 54, Issue:2	Effects of ceftobiprole and oxacillin on mecA expression in methicillin-resistant Staphylococcus aureus clinical isolates.
AID759327	Antibacterial activity against Staphylococcus aureus KCTC 209 after 24 hrs by broth microdilution method	2013	Bioorganic & medicinal chemistry letters, Aug-01, Volume: 23, Issue:15	Synthesis and biological evaluation of rhodanine derivatives bearing a quinoline moiety as potent antimicrobial agents.
AID1698472	Antimicrobial activity against methicillin-sensitive Staphylococcus aureus ATCC 29213 assessed as reduction in microbial growth after 24 hrs by microdilution method	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Paecilosetin Derivatives as Potent Antimicrobial Agents from
AID409957	Inhibition of bovine liver MAOA	2008	Journal of medicinal chemistry, Nov-13, Volume: 51, Issue:21	Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.
AID553669	Chemical stability of the compound assessed as compound remaining after 24 hrs in PBS buffer by HPLC analysis at pH 7.4	2008	Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8	Restoration of susceptibility of intracellular methicillin-resistant Staphylococcus aureus to beta-lactams: comparison of strains, cells, and antibiotics.
AID432972	Antimicrobial activity against SCCmec type 4 methicillin-resistant Staphylococcus aureus COL MW2-T expressing symporter gene smr1 at 42 degC incubated for 24 hrs by E-test	2008	Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2	Role of a sodium-dependent symporter homologue in the thermosensitivity of beta-lactam antibiotic resistance and cell wall composition in Staphylococcus aureus.
AID529123	Antimicrobial activity against methicillin-resistant Staphylococcus aureus BK2464 assessed as concentration required for bacterial subpopulation growth	2008	Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8	Comparative study of the susceptibilities of major epidemic clones of methicillin-resistant Staphylococcus aureus to oxacillin and to the new broad-spectrum cephalosporin ceftobiprole.
AID658537	Antibacterial activity against Staphylococcus aureus EMRSA-15 after 24 hrs	2012	Journal of natural products, Mar-23, Volume: 75, Issue:3	Antibacterial acylphloroglucinols from Hypericum olympicum.
AID475610	Antimicrobial activity against methicillin-sensitive Staphylococcus aureus isolate 2	2010	Bioorganic & medicinal chemistry letters, Apr-01, Volume: 20, Issue:7	7-Phenylplatensimycin and 11-methyl-7-phenylplatensimycin: more potent analogs of platensimycin.
AID761552	Antibacterial activity against Klebsiella pneumoniae 2011E by M07-A9 CLSI method	2013	Bioorganic & medicinal chemistry letters, Aug-01, Volume: 23, Issue:15	Synthesis and antimicrobial activity of imidazole and pyridine appended cholestane-based conjugates.
AID362541	Antibacterial activity against methicillin-resistant Staphylococcus aureus SA1199B after 18 hrs	2008	Journal of natural products, Aug, Volume: 71, Issue:8	Antibacterial cannabinoids from Cannabis sativa: a structure-activity study.
AID529130	Antimicrobial activity against methicillin-resistant Staphylococcus aureus HU25 assessed as concentration required for bacterial subpopulation growth	2008	Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8	Comparative study of the susceptibilities of major epidemic clones of methicillin-resistant Staphylococcus aureus to oxacillin and to the new broad-spectrum cephalosporin ceftobiprole.
AID544601	Effect on growth of Staphylococcus aureus isolate 6083 assessed as highest compound concentration at which cell growth occurred measured after 48 hrs	2008	Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11	In vitro and in vivo evaluations of oxacillin efficiency against mecA-positive oxacillin-susceptible Staphylococcus aureus.
AID759322	Antibacterial activity against quinolone-resistant Staphylococcus aureus CCARM 3505 after 24 hrs by broth microdilution method	2013	Bioorganic & medicinal chemistry letters, Aug-01, Volume: 23, Issue:15	Synthesis and biological evaluation of rhodanine derivatives bearing a quinoline moiety as potent antimicrobial agents.
AID1869529	Antibacterial activity against multidrug-resistant Morganella morganii KL-225 measured after 24 hrs by broth microdilution method
AID424425	Antibacterial activity against Enterococcus faecalis AIS2007003 isolated from patients rectum by broth microdilution method	2008	Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2	Vancomycin-resistant Staphylococcus aureus isolates associated with Inc18-like vanA plasmids in Michigan.
AID1737461	Antibacterial activity against methicillin resistant Staphylococcus aureus S-41 after 16 to 18 hrs by CLSI-based microbroth dilution method	2020	European journal of medicinal chemistry, Jun-01, Volume: 195	Synthesis of novel monocarbonyl curcuminoids, evaluation of their efficacy against MRSA, including ex vivo infection model and their mechanistic studies.
AID584121	Antimicrobial activity against methicillin-resistant Staphylococcus aureus ST398 isolate 11 containing apmA, erm(B), tet(L), tet(M), tet(K), dfrK, aadD, mecA, blaZ resistance genes by CLSI M31-A3 method	2011	Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1	Novel apramycin resistance gene apmA in bovine and porcine methicillin-resistant Staphylococcus aureus ST398 isolates.
AID396029	Antibacterial activity against drug-resistant AcrAB-TolC efflux pump deficient Enterobacter cloacae EcdeltaacrA isolate in presence of 20 ug/ml efflux pump inhibitor Phe-Arg-beta-naphthylamide by Etest	2007	Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9	Cloning, nucleotide sequencing, and analysis of the AcrAB-TolC efflux pump of Enterobacter cloacae and determination of its involvement in antibiotic resistance in a clinical isolate.
AID278912	Antibacterial activity against coagulase-negative staphylococci	2007	Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1	In vitro antibacterial activity of the pyrrolopyrazolyl-substituted oxazolidinone RWJ-416457.
AID278667	Antibacterial activity against methicillin-resistant Staphylococcus aureus isolate 2513	2007	Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1	High-level vancomycin-resistant Staphylococcus aureus isolates associated with a polymicrobial biofilm.
AID658538	Antibacterial activity against Staphylococcus aureus EMRSA-16 after 24 hrs	2012	Journal of natural products, Mar-23, Volume: 75, Issue:3	Antibacterial acylphloroglucinols from Hypericum olympicum.
AID1763149	Antibacterial activity against Staphylococcus aureus ATCC 29213 assessed as reduction in bacterial growth incubated for 24 hrs by CLSI based serial dilution method	2021	Bioorganic & medicinal chemistry, 05-15, Volume: 38	Antibacterial and synergistic activity of 6β-hydroxy-3-oxolup-20(29)-en-28-oic acid (6β-hydroxy betunolic acid) isolated from Schumacheria castaneifolia vahl.
AID1567124	Antimicrobial activity against Enterococcus casseliflavus ATCC 25788 incubated for 20 hrs by microdilution method	2019	European journal of medicinal chemistry, Sep-15, Volume: 178	Design, synthesis and biological evaluation of antimicrobial diarylimine and -amine compounds targeting the interaction between the bacterial NusB and NusE proteins.
AID1827145	Antibacterial activity against methicillin-resistant Staphylococcus aureus USA300 assessed as inhibition of bacterial growth after 18 hrs in presence of oxacillin by CLSI protocol based broth microdilution assay	2022	ACS medicinal chemistry letters, Mar-10, Volume: 13, Issue:3	Identification and Evaluation of Brominated Carbazoles as a Novel Antibiotic Adjuvant Scaffold in MRSA.
AID422496	Activity of Carnobacterium divergens BM4489 penicillinase Cad-1 assessed as initial rate of hydrolysis by spectrophotometer	2008	Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2	Genetic and biochemical characterization of CAD-1, a chromosomally encoded new class A penicillinase from Carnobacterium divergens.
AID396033	Antibacterial activity against drug-resistant AcrAB-TolC efflux pump deficient Enterobacter cloacae EcdeltaacrA isolate expressing pBGS18 plasmid by Etest	2007	Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9	Cloning, nucleotide sequencing, and analysis of the AcrAB-TolC efflux pump of Enterobacter cloacae and determination of its involvement in antibiotic resistance in a clinical isolate.
AID523271	Lipophilicity, log P of the compound	2010	Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5	Kinetic parameters of efflux of penicillins by the multidrug efflux transporter AcrAB-TolC of Escherichia coli.
AID519632	Activity of beta-lactamase FUS1 assessed as compound hydrolysis by spectrophotometry	2008	Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4	Genetic and biochemical characterization of OXA-63, a new class D beta-lactamase from Brachyspira pilosicoli BM4442.
AID575146	Antimicrobial activity against methicillin-resistant Staphylococcus aureus isolate NRS123 by broth microdilution method	2010	Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9	Inhibition of antibiotic-resistant Staphylococcus aureus by the broad-spectrum dihydrofolate reductase inhibitor RAB1.
AID509054	Antibacterial activity against beta-lactamase positive SCCmec type 1 methicillin-resistant Staphylococcus aureus isolate 11631 by broth microdilution method	2010	Antimicrobial agents and chemotherapy, Feb, Volume: 54, Issue:2	Effects of ceftobiprole and oxacillin on mecA expression in methicillin-resistant Staphylococcus aureus clinical isolates.
AID1601848	Antibacterial activity against Escherichia coli CMCC 44568 measured after 24 hrs by ELISA	2019	European journal of medicinal chemistry, Mar-15, Volume: 166	Synthesis, antimicrobial and cytotoxic activities, and molecular docking studies of N-arylsulfonylindoles containing an aminoguanidine, a semicarbazide, and a thiosemicarbazide moiety.
AID1242546	Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC 43300 after 20 to 24 hrs by CLSI method	2015	ACS medicinal chemistry letters, Jul-09, Volume: 6, Issue:7	Triazole-Linked Glycolipids Enhance the Susceptibility of MRSA to β-Lactam Antibiotics.
AID559050	Antibacterial activity against Staphylococcus hominis by CLSI M100-S18 method	2009	Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8	Besifloxacin, a novel fluoroquinolone, has broad-spectrum in vitro activity against aerobic and anaerobic bacteria.
AID584995	Antibacterial activity against pSCFS7-deficient methicillin-resistant Staphylococcus aureus M05/0060-C1 by broth microdilution method	2010	Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12	Identification and characterization of the multidrug resistance gene cfr in a Panton-Valentine leukocidin-positive sequence type 8 methicillin-resistant Staphylococcus aureus IVa (USA300) isolate.
AID1294671	Antimicrobial activity against methicillin-resistant Staphylococcus aureus isolate 17a after 24 hrs by agar plate dilution method	2016	European journal of medicinal chemistry, Jun-10, Volume: 115	Anti-methicillin resistant Staphylococcus aureus activity, synergism with oxacillin and molecular docking studies of metronidazole-triazole hybrids.
AID1079947	Comments (NB not yet translated). [column 'COMMENTAIRES' in source]
AID1737455	Antibacterial activity against methicillin resistant Staphylococcus aureus ATCC 33591 after 16 to 18 hrs by CLSI-based microbroth dilution method	2020	European journal of medicinal chemistry, Jun-01, Volume: 195	Synthesis of novel monocarbonyl curcuminoids, evaluation of their efficacy against MRSA, including ex vivo infection model and their mechanistic studies.
AID565761	Antimicrobial activity against Staphylococcus aureus clinical isolates by broth microdilution method	2009	Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11	Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates.
AID545952	Antimicrobial activity against methicillin-resistant Staphylococcus aureus 16652 by broth dilution method	2010	Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8	Identification of a novel transposon (Tn6072) and a truncated staphylococcal cassette chromosome mec element in methicillin-resistant Staphylococcus aureus ST239.
AID530765	Induction of PvraSr::lacZ gene expression in Staphylococcus aureus SH1000 at 8 ug/ml after 2 hrs by beta-galactosidase reporter gene assay relative to untreated control	2008	Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8	Staphylococcus aureus cell wall stress stimulon gene-lacZ fusion strains: potential for use in screening for cell wall-active antimicrobials.
AID565005	Antimicrobial activity against methicillin-susceptible coagulase-negative Staphylococcus epidermidis assessed as susceptible isolates after 24 hrs by broth microdilution method	2009	Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10	In vitro activities of panduratin A against clinical Staphylococcus strains.
AID530767	Induction of PlytR::lacZ gene expression in Staphylococcus aureus SH1000 at 8 ug/ml after 2 hrs by beta-galactosidase reporter gene assay relative to untreated control	2008	Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8	Staphylococcus aureus cell wall stress stimulon gene-lacZ fusion strains: potential for use in screening for cell wall-active antimicrobials.
AID564808	Antimicrobial activity against methicillin-resistant coagulase-negative Staphylococcus simulans after 24 hrs by broth microdilution method	2009	Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10	In vitro activities of panduratin A against clinical Staphylococcus strains.
AID1294662	Antimicrobial activity against methicillin-resistant Staphylococcus aureus isolate 8a after 24 hrs by agar plate dilution method	2016	European journal of medicinal chemistry, Jun-10, Volume: 115	Anti-methicillin resistant Staphylococcus aureus activity, synergism with oxacillin and molecular docking studies of metronidazole-triazole hybrids.
AID1330196	Antibacterial activity against quinolone-resistant Staphylococcus aureus 3505 measured after 24 hrs by two-fold serial dilution method	2016	Bioorganic & medicinal chemistry letters, 12-15, Volume: 26, Issue:24	Synthesis and biological evaluation of chalcone derivatives containing aminoguanidine or acylhydrazone moieties.
AID285346	Antibacterial activity against Staphylococcus aureus LUG855 in CCY media	2007	Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4	Effect of antibiotics on Staphylococcus aureus producing Panton-Valentine leukocidin.
AID584475	Antibacterial activity against mecA-negative Staphylococcus vitulinus SVMN05 by agar dilution method	2010	Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10	Origin and molecular evolution of the determinant of methicillin resistance in staphylococci.
AID576133	Antibacterial activity against 10'4 to 10'5 CFU Moraxella catarrhalis after 18 hrs by CLSI 2-fold agar dilution method	2010	Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12	In vitro and in vivo activities of LCB01-0371, a new oxazolidinone.
AID521066	Antibacterial activity against group 1-v1 PVL+ community-acquired methicillin-resistant Staphylococcus aureus ST 59 expressing SCCmec type V gene by agar dilution method	2008	Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3	Novel characteristics of community-acquired methicillin-resistant Staphylococcus aureus strains belonging to multilocus sequence type 59 in Taiwan.
AID1055340	Antibacterial activity against methicillin-resistant Staphylococcus aureus R6101 assessed as growth inhibition after 18 hrs by agar dilution method	2013	Journal of natural products, Nov-22, Volume: 76, Issue:11	Identification of elaiophylin derivatives from the marine-derived actinomycete Streptomyces sp. 7-145 using PCR-based screening.
AID431114	Antibacterial activity against graSR gene knockout heterogeneous vancomycin-intermediate Staphylococcus aureus Mu3 after 24 hrs by agar dilution method	2008	Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1	Mutated response regulator graR is responsible for phenotypic conversion of Staphylococcus aureus from heterogeneous vancomycin-intermediate resistance to vancomycin-intermediate resistance.
AID520869	Antibacterial activity against methicillin-resistant mecA-positive Staphylococcus saprophyticus isolate TSU33 isolated from genitourinary tracts of acute cystitis patient after 24 hrs at 35 degC by agar dilution method	2008	Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6	Methicillin-resistant Staphylococcus saprophyticus isolates carrying staphylococcal cassette chromosome mec have emerged in urogenital tract infections.
AID1706286	Protein binding in plasma (unknown origin)	2020	European journal of medicinal chemistry, Dec-15, Volume: 208	β-lactam antibiotics: An overview from a medicinal chemistry perspective.
AID583692	Antimicrobial activity against methicillin-resistant Staphylococcus aureus 10*3d1 harboring hypothetical protein SA1826 14E mutant gene after 24 hrs by Etest method	2010	Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12	An RpoB mutation confers dual heteroresistance to daptomycin and vancomycin in Staphylococcus aureus.
AID431093	Antibacterial activity against vancomycin-susceptible Staphylococcus aureus N315 after 48 hrs by agar dilution method	2008	Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1	Mutated response regulator graR is responsible for phenotypic conversion of Staphylococcus aureus from heterogeneous vancomycin-intermediate resistance to vancomycin-intermediate resistance.
AID509064	Induction of mecA gene expression in beta-lactamase positive SCCmec type 2 methicillin-resistant Staphylococcus aureus isolate 11521 at MIC after 1 hr by multiplex PCR method	2010	Antimicrobial agents and chemotherapy, Feb, Volume: 54, Issue:2	Effects of ceftobiprole and oxacillin on mecA expression in methicillin-resistant Staphylococcus aureus clinical isolates.
AID475619	Antimicrobial activity against vancomycin-sensitive Enterococcus faecalis isolate 11	2010	Bioorganic & medicinal chemistry letters, Apr-01, Volume: 20, Issue:7	7-Phenylplatensimycin and 11-methyl-7-phenylplatensimycin: more potent analogs of platensimycin.
AID508840	Induction of mecA gene expression in beta-lactamase positive SCCmec type nontypeable methicillin-resistant Staphylococcus aureus isolate 17329 at MIC after 1 hr by multiplex PCR method	2010	Antimicrobial agents and chemotherapy, Feb, Volume: 54, Issue:2	Effects of ceftobiprole and oxacillin on mecA expression in methicillin-resistant Staphylococcus aureus clinical isolates.
AID540212	Mean residence time in human after iv administration	2008	Drug metabolism and disposition: the biological fate of chemicals, Jul, Volume: 36, Issue:7	Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
AID509056	Antibacterial activity against beta-lactamase positive SCCmec type 1 methicillin-resistant Staphylococcus aureus isolate 12575 by broth microdilution method	2010	Antimicrobial agents and chemotherapy, Feb, Volume: 54, Issue:2	Effects of ceftobiprole and oxacillin on mecA expression in methicillin-resistant Staphylococcus aureus clinical isolates.
AID1482267	Antibacterial activity against Escherichia coli MG1655 measured every 15 mins for 12 hrs	2017	Journal of medicinal chemistry, 05-11, Volume: 60, Issue:9	Prediction of Antibiotic Interactions Using Descriptors Derived from Molecular Structure.
AID560504	Antimicrobial activity against SCCmec type III vancomycin-intermediate Staphylococcus aureus isolate bd4768 by agar dilution method	2009	Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9	Prevalence and characterization of heterogeneous vancomycin-intermediate Staphylococcus aureus isolates from 14 cities in China.
AID685403	Antibacterial activity against Staphylococcus aureus RN4220 after 24 hrs by broth microdilution method	2012	European journal of medicinal chemistry, Oct, Volume: 56	Synthesis and antimicrobial evaluation of L-phenylalanine-derived C5-substituted rhodanine and chalcone derivatives containing thiobarbituric acid or 2-thioxo-4-thiazolidinone.
AID521068	Antibacterial activity against group 1-v3 PVL+ community-acquired methicillin-resistant Staphylococcus aureus ST 59 expressing SCCmec type V gene by agar dilution method	2008	Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3	Novel characteristics of community-acquired methicillin-resistant Staphylococcus aureus strains belonging to multilocus sequence type 59 in Taiwan.
AID520731	Activity of Escherichia coli DH10B beta-lactamase OXA-97 assessed per mg of protein at 100 uM	2008	Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5	Carbapenem-resistant Acinetobacter baumannii isolates from Tunisia producing the OXA-58-like carbapenem-hydrolyzing oxacillinase OXA-97.
AID285506	Antibacterial activity against methicillin-susceptible Staphylococcus aureus after 24 hrs by broth microdilution method	2007	Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4	In vitro and in vivo antibacterial activities of heteroaryl isothiazolones against resistant gram-positive pathogens.
AID577708	Antibacterial activity against 10'7 CFU/ml telA-deficient Listeria monocytogenes EGD-e Serovar 1/2a at 1 ug after 16 hrs by disk diffusion assay	2010	Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11	TelA contributes to the innate resistance of Listeria monocytogenes to nisin and other cell wall-acting antibiotics.
AID521078	Antibacterial activity against group 6 PVL negative community-acquired methicillin-resistant Staphylococcus aureus ST 8 expressing SCCmec type IVx gene by agar dilution method	2008	Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3	Novel characteristics of community-acquired methicillin-resistant Staphylococcus aureus strains belonging to multilocus sequence type 59 in Taiwan.
AID1827259	Upregulation of mecA gene expression in methicillin-resistant Staphylococcus aureus USA100 by RT-PCR method	2022	ACS medicinal chemistry letters, Mar-10, Volume: 13, Issue:3	Identification and Evaluation of Brominated Carbazoles as a Novel Antibiotic Adjuvant Scaffold in MRSA.
AID561077	Antibacterial activity against methicillin-susceptible Staphylococcus epidermidis by CLSI M7-A7 broth microdilution method	2009	Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8	In vitro activity of TR-700, the active ingredient of the antibacterial prodrug TR-701, a novel oxazolidinone antibacterial agent.
AID1294670	Antimicrobial activity against methicillin-resistant Staphylococcus aureus isolate 16a after 24 hrs by agar plate dilution method	2016	European journal of medicinal chemistry, Jun-10, Volume: 115	Anti-methicillin resistant Staphylococcus aureus activity, synergism with oxacillin and molecular docking studies of metronidazole-triazole hybrids.
AID529120	Antimicrobial activity against methicillin-resistant Staphylococcus aureus HU25 by Etest	2008	Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8	Comparative study of the susceptibilities of major epidemic clones of methicillin-resistant Staphylococcus aureus to oxacillin and to the new broad-spectrum cephalosporin ceftobiprole.
AID1853471	Antibacterial activity against methicillin-resistant Staphylococcus aureus ST239 (ARLG 1663) assessed as bacterial growth inhibition incubated for 18 to 20 hrs by CLSI based broth microdilution assay	2021	RSC medicinal chemistry, Nov-17, Volume: 12, Issue:11	SF
AID694205	Antibacterial activity against methicillin-sensitive Staphylococcus aureus 8325-4 by CLSI broth microdilution method	2012	Bioorganic & medicinal chemistry letters, Nov-15, Volume: 22, Issue:22	Antibacterial activity of substituted dibenzo[a,g]quinolizin-7-ium derivatives.
AID750315	Antibacterial activity against Staphylococcus aureus isolate D12 derived from ulcer and furuncle assessed as growth inhibition after 18 hrs by broth microdilution method	2013	European journal of medicinal chemistry, Jun, Volume: 64	Synthesis and evaluation of antimicrobial activity of hydrazones derived from 3-oxido-1H-imidazole-4-carbohydrazides.
AID564806	Antimicrobial activity against methicillin-susceptible Staphylococcus aureus after 24 hrs by broth microdilution method	2009	Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10	In vitro activities of panduratin A against clinical Staphylococcus strains.
AID1517066	Antibacterial activity against Staphylococcus aureus ATCC 29213 assessed as reduction in bacterial growth incubated for 24 hrs by serial dilution method	2019	European journal of medicinal chemistry, Dec-01, Volume: 183	Two optimized antimicrobial peptides with therapeutic potential for clinical antibiotic-resistant Staphylococcus aureus.
AID325477	Antibacterial activity against Staphylococcus aureus Mu50 at 20 ug/ml after 12 hrs by time kill assay	2007	Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6	Polyamine effects on antibiotic susceptibility in bacteria.
AID576137	Antibacterial activity against 10'4 to 10'5 CFU Streptococcus pyogenes after 18 hrs by CLSI 2-fold agar dilution method	2010	Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12	In vitro and in vivo activities of LCB01-0371, a new oxazolidinone.
AID564821	Antimicrobial activity against methicillin-resistant coagulase-negative Staphylococcus hominis after 24 hrs by broth microdilution method	2009	Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10	In vitro activities of panduratin A against clinical Staphylococcus strains.
AID396031	Antibacterial activity against drug-resistant AcrAB-TolC efflux pump deficient Enterobacter cloacae EcdeltaacrA isolate expressing pACYC184 plasmid by Etest	2007	Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9	Cloning, nucleotide sequencing, and analysis of the AcrAB-TolC efflux pump of Enterobacter cloacae and determination of its involvement in antibiotic resistance in a clinical isolate.
AID325152	Antimicrobial activity against Haemophilus parasuis BB 1019	2007	Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6	Beta-lactam resistance in Haemophilus parasuis Is mediated by plasmid pB1000 bearing blaROB-1.
AID560516	Antimicrobial activity against SCCmec type III vancomycin-intermediate Staphylococcus aureus isolate 11b091 by agar dilution method	2009	Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9	Prevalence and characterization of heterogeneous vancomycin-intermediate Staphylococcus aureus isolates from 14 cities in China.
AID543952	Antibacterial activity against tetracycline-resistant Staphylococcus aureus COL-S carrying SAmecA plasmid	2009	Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2	Reconstruction of the phenotypes of methicillin-resistant Staphylococcus aureus by replacement of the staphylococcal cassette chromosome mec with a plasmid-borne copy of Staphylococcus sciuri pbpD gene.
AID567449	Antimicrobial activity against methicillin-resistant Staphylococcus aureus CGK1 by Etest method	2010	Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9	Development of daptomycin nonsusceptibility with heterogeneous vancomycin-intermediate resistance and oxacillin susceptibility in methicillin-resistant Staphylococcus aureus during high-dose daptomycin treatment.
AID1737459	Antibacterial activity against methicillin resistant Staphylococcus aureus S-34 after 16 to 18 hrs by CLSI-based microbroth dilution method	2020	European journal of medicinal chemistry, Jun-01, Volume: 195	Synthesis of novel monocarbonyl curcuminoids, evaluation of their efficacy against MRSA, including ex vivo infection model and their mechanistic studies.
AID429357	Antimicrobial activity against methicillin-susceptible Staphylococcus aureus isolate 1	2009	Bioorganic & medicinal chemistry letters, Aug-15, Volume: 19, Issue:16	Isoplatensimycin: Synthesis and biological evaluation.
AID567452	Antimicrobial activity against methicillin-resistant Staphylococcus aureus CGK4 by Etest method	2010	Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9	Development of daptomycin nonsusceptibility with heterogeneous vancomycin-intermediate resistance and oxacillin susceptibility in methicillin-resistant Staphylococcus aureus during high-dose daptomycin treatment.
AID1524626	Antibacterial activity against methicillin-resistant Staphylococcus aureus CCARM 3167 after 24 hrs by microtiter ELISA	2019	Bioorganic & medicinal chemistry letters, 05-01, Volume: 29, Issue:9	Synthesis of novel dihydrotriazine derivatives bearing 1,3-diaryl pyrazole moieties as potential antibacterial agents.
AID285933	Antimicrobial activity against methicillin-susceptible Staphylococcus aureus ATCC 29213 in human monocyte-derived macrophages at 0.5 ug/ml assessed as bacterial viability after 2 hrs	2007	Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4	Antimicrobial activities of daptomycin, vancomycin, and oxacillin in human monocytes and of daptomycin in combination with gentamicin and/or rifampin in human monocytes and in broth against Staphylococcus aureus.
AID432984	Antimicrobial activity against SCCmec type 1 methicillin-resistant Staphylococcus aureus COL 404-T3 expressing symporter gene smr1 at 42 degC incubated for 24 hrs by E-test	2008	Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2	Role of a sodium-dependent symporter homologue in the thermosensitivity of beta-lactam antibiotic resistance and cell wall composition in Staphylococcus aureus.
AID1651723	Antibacterial activity against Methicillin-resistant Staphylococcus aureus MB18 after 24 hrs by microdilution assay	2020	Journal of natural products, 04-24, Volume: 83, Issue:4	Antibacterial and ATP Synthesis Modulating Compounds from
AID565018	Antimicrobial activity against methicillin-susceptible coagulase-negative Staphylococcus sciuri assessed as resistant isolates after 24 hrs by broth microdilution method	2009	Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10	In vitro activities of panduratin A against clinical Staphylococcus strains.
AID325446	Antibacterial activity against Salmonella enterica serovar Typhimurium LT2 after 14 to 16 hrs by broth dilution method	2007	Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6	Polyamine effects on antibiotic susceptibility in bacteria.
AID1079946	Presence of at least one case with successful reintroduction. [column 'REINT' in source]
AID1737457	Antibacterial activity against methicillin resistant Staphylococcus aureus S-30 after 16 to 18 hrs by CLSI-based microbroth dilution method	2020	European journal of medicinal chemistry, Jun-01, Volume: 195	Synthesis of novel monocarbonyl curcuminoids, evaluation of their efficacy against MRSA, including ex vivo infection model and their mechanistic studies.
AID573113	Antibacterial activity against methicillin-susceptible Staphylococcus aureus by CLSI M7-A7 broth microdilution method	2008	Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9	In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States.
AID609224	Antibacterial activity against 10'5 CFU/mL methicillin-resistant Staphylococcus aureus CCARM 3506 assessed as inhibition of bacterial growth after 24 hrs by microtiter enzyme-linked immunosorbent assay	2011	European journal of medicinal chemistry, Aug, Volume: 46, Issue:8	Synthesis of new chalcone derivatives bearing 2,4-thiazolidinedione and benzoic acid moieties as potential anti-bacterial agents.
AID1517069	Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC 18475 assessed as reduction in bacterial growth incubated for 24 hrs by serial dilution method	2019	European journal of medicinal chemistry, Dec-01, Volume: 183	Two optimized antimicrobial peptides with therapeutic potential for clinical antibiotic-resistant Staphylococcus aureus.
AID565759	Antimicrobial activity against oxacillin-resistant Staphylococcus aureus clinical isolates by broth microdilution method	2009	Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11	Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates.
AID545953	Antimicrobial activity against methicillin-resistant Staphylococcus aureus 16653 by broth dilution method	2010	Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8	Identification of a novel transposon (Tn6072) and a truncated staphylococcal cassette chromosome mec element in methicillin-resistant Staphylococcus aureus ST239.
AID1827265	Upregulation of mecA gene expression in methicillin-resistant Staphylococcus aureus COL by RT-PCR method	2022	ACS medicinal chemistry letters, Mar-10, Volume: 13, Issue:3	Identification and Evaluation of Brominated Carbazoles as a Novel Antibiotic Adjuvant Scaffold in MRSA.
AID533115	Antimicrobial activity against methicillin-resistant Staphylococcus aureus N315DeltaIP by Etest method	2008	Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12	Serial daptomycin selection generates daptomycin-nonsusceptible Staphylococcus aureus strains with a heterogeneous vancomycin-intermediate phenotype.
AID1225389	Antibacterial activity against Escherichia coli transformed with plasmid carrying MG1655 deltaBC/pXYM by p-iodonitrotetrazolium chloride colorimetric assay	2015	Journal of natural products, Mar-27, Volume: 78, Issue:3	Enhancement of antibiotic activity against multidrug-resistant bacteria by the efflux pump inhibitor 3,4-dibromopyrrole-2,5-dione isolated from a Pseudoalteromonas sp.
AID405600	Increase in mnhG gene expression in oxacillin-dependent methicillin-resistant Staphylococcus aureus 2884D isolate at 0.5 ug/ml by microarray-based transcriptional profiling relative to control	2007	Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7	Identification and phenotypic characterization of a beta-lactam-dependent, methicillin-resistant Staphylococcus aureus strain.
AID405597	Increase in fmtB gene expression in oxacillin-dependent methicillin-resistant Staphylococcus aureus 2884D isolate at 0.5 ug/ml by microarray-based transcriptional profiling relative to control	2007	Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7	Identification and phenotypic characterization of a beta-lactam-dependent, methicillin-resistant Staphylococcus aureus strain.
AID325156	Antimicrobial activity against Haemophilus parasuis BB 1023	2007	Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6	Beta-lactam resistance in Haemophilus parasuis Is mediated by plasmid pB1000 bearing blaROB-1.
AID405603	Increase in mecA gene expression in oxacillin-dependent methicillin-resistant Staphylococcus aureus 2884D isolate at 0.5 ug/ml by microarray-based transcriptional profiling relative to control	2007	Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7	Identification and phenotypic characterization of a beta-lactam-dependent, methicillin-resistant Staphylococcus aureus strain.
AID584305	Antibacterial activity against methicillin-resistant mecA-positive Staphylococcus vitulinus SVMP02 by agar dilution method	2010	Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10	Origin and molecular evolution of the determinant of methicillin resistance in staphylococci.
AID1304325	Antibacterial activity against methicillin-resistant Staphylococcus aureus USA300 SF8300 assessed as growth inhibition after 18 to 20 hrs by microdilution assay	2016	Bioorganic & medicinal chemistry letters, 07-01, Volume: 26, Issue:13	Caged xanthones: Potent inhibitors of global predominant MRSA USA300.
AID545963	Antimicrobial activity against methicillin-resistant Staphylococcus aureus 16687 by broth dilution method	2010	Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8	Identification of a novel transposon (Tn6072) and a truncated staphylococcal cassette chromosome mec element in methicillin-resistant Staphylococcus aureus ST239.
AID540210	Clearance in human after iv administration	2008	Drug metabolism and disposition: the biological fate of chemicals, Jul, Volume: 36, Issue:7	Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
AID545975	Antimicrobial activity against methicillin-resistant Staphylococcus aureus 16691 by broth dilution method	2010	Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8	Identification of a novel transposon (Tn6072) and a truncated staphylococcal cassette chromosome mec element in methicillin-resistant Staphylococcus aureus ST239.
AID545973	Antimicrobial activity against methicillin-resistant Staphylococcus aureus 16688 by broth dilution method	2010	Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8	Identification of a novel transposon (Tn6072) and a truncated staphylococcal cassette chromosome mec element in methicillin-resistant Staphylococcus aureus ST239.
AID556045	Antimicrobial activity against erythromycin-, glycopepeptide-intermediate-resistant and yabJ-spoVG operon deficient Staphylococcus aureus SM159 by broth microdilution method	2009	Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5	Functional characterization of the sigmaB-dependent yabJ-spoVG operon in Staphylococcus aureus: role in methicillin and glycopeptide resistance.
AID609222	Antibacterial activity against 10'5 CFU/mL Escherichia coli 1682 assessed as inhibition of bacterial growth after 24 hrs by microtiter enzyme-linked immunosorbent assay	2011	European journal of medicinal chemistry, Aug, Volume: 46, Issue:8	Synthesis of new chalcone derivatives bearing 2,4-thiazolidinedione and benzoic acid moieties as potential anti-bacterial agents.
AID745591	Antibacterial activity against Staphylococcus aureus ATCC 29213 assessed as growth inhibition after 24 hrs by CLSI microdilution method	2013	Journal of natural products, May-24, Volume: 76, Issue:5	Antifungal agents from Pseudallescheria boydii SNB-CN73 isolated from a Nasutitermes sp. termite.
AID531563	Antibacterial activity against methicillin-resistant, oxacillin-susceptible, coagulase-negative, mecA-positive Staphylococcus lugdunensis obtained from complicated skin and skin structure infections by agar dilution method	2008	Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9	In vitro activity of ceftobiprole against pathogens from two phase 3 clinical trials of complicated skin and skin structure infections.
AID519452	Antimicrobial activity against oxacillin sensitive and vancomycin resistant Staphylococcus aureus isolate 3130VR by broth microdilution method	2008	Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4	Spontaneous deletion of the methicillin resistance determinant, mecA, partially compensates for the fitness cost associated with high-level vancomycin resistance in Staphylococcus aureus.
AID404949	Antibacterial activity against methicillin-resistant Staphylococcus aureus isolate assessed as percent resistant isolates by CLSI dilution method	2007	Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7	In vitro activities of CG400549, a novel FabI inhibitor, against recently isolated clinical staphylococcal strains in Korea.
AID531561	Antibacterial activity against coagulase-negative Staphylococcus sciuri obtained from complicated skin and skin structure infections by agar dilution method	2008	Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9	In vitro activity of ceftobiprole against pathogens from two phase 3 clinical trials of complicated skin and skin structure infections.
AID584294	Antibacterial activity against methicillin-resistant mecA-positive Staphylococcus fleurettii SFMP04 by agar dilution method	2010	Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10	Origin and molecular evolution of the determinant of methicillin resistance in staphylococci.
AID561075	Antibacterial activity against methicillin-resistant Staphylococcus aureus by CLSI M7-A7 broth microdilution method	2009	Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8	In vitro activity of TR-700, the active ingredient of the antibacterial prodrug TR-701, a novel oxazolidinone antibacterial agent.
AID584122	Antimicrobial activity against Staphylococcus aureus RN4220 by CLSI M31-A3 method	2011	Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1	Novel apramycin resistance gene apmA in bovine and porcine methicillin-resistant Staphylococcus aureus ST398 isolates.
AID276299	Antibacterial activity against methicillin-resistant Staphylococcus aureus 20653 at 256 ug/ml	2006	Bioorganic & medicinal chemistry letters, Nov-15, Volume: 16, Issue:22	Solid-phase synthesis and antibacterial activity of hydroxycinnamic acid amides and analogues against methicillin-resistant Staphylococcus aureus and vancomycin-resistant S. aureus.
AID405594	Increase in ribosomal protein L34 gene expression in oxacillin-dependent methicillin-resistant Staphylococcus aureus 2884D isolate at 0.5 ug/ml by microarray-based transcriptional profiling relative to control	2007	Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7	Identification and phenotypic characterization of a beta-lactam-dependent, methicillin-resistant Staphylococcus aureus strain.
AID584478	Antibacterial activity against mecA-negative Staphylococcus vitulinus SVMN08 by agar dilution method	2010	Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10	Origin and molecular evolution of the determinant of methicillin resistance in staphylococci.
AID533117	Antimicrobial activity against Staphylococcus aureus 10*3d1 by Etest method	2008	Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12	Serial daptomycin selection generates daptomycin-nonsusceptible Staphylococcus aureus strains with a heterogeneous vancomycin-intermediate phenotype.
AID565016	Antimicrobial activity against methicillin-susceptible coagulase-negative Staphylococcus sciuri after 24 hrs by broth microdilution method	2009	Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10	In vitro activities of panduratin A against clinical Staphylococcus strains.
AID1517071	Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC 18858 assessed as reduction in bacterial growth incubated for 24 hrs by serial dilution method	2019	European journal of medicinal chemistry, Dec-01, Volume: 183	Two optimized antimicrobial peptides with therapeutic potential for clinical antibiotic-resistant Staphylococcus aureus.
AID667556	Antibacterial activity against Staphylococcus aureus KCTC 209 after 24 hrs by two-fold serial dilution method	2012	European journal of medicinal chemistry, Aug, Volume: 54	Synthesis and bioactivity evaluation of rhodanine derivatives as potential anti-bacterial agents.
AID542627	Antimicrobial activity against streptomycin-resistant Streptococcus pneumoniae R6 harboring PBP2x T338G and PBP1a2349 mutant gene and aad9 disruption in CiaR gene after 48 hrs by agar dilution method	2009	Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3	An important site in PBP2x of penicillin-resistant clinical isolates of Streptococcus pneumoniae: mutational analysis of Thr338.
AID574303	Antimicrobial activity against hospital-acquired pbp4-deficient Staphylococcus aureus COL serotype USA500 by microdilution method	2008	Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11	Staphylococcus aureus PBP4 is essential for beta-lactam resistance in community-acquired methicillin-resistant strains.
AID667555	Antibacterial activity against Staphylococcus aureus KCTC 4220 after 24 hrs by two-fold serial dilution method	2012	European journal of medicinal chemistry, Aug, Volume: 54	Synthesis and bioactivity evaluation of rhodanine derivatives as potential anti-bacterial agents.
AID531564	Antibacterial activity against methicillin-susceptible, coagulase-negative Staphylococcus obtained from complicated skin and skin structure infections by agar dilution method	2008	Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9	In vitro activity of ceftobiprole against pathogens from two phase 3 clinical trials of complicated skin and skin structure infections.
AID531552	Antibacterial activity against methicillin resistant Staphylococcus aureus obtained from complicated skin and skin structure infections by agar dilution method	2008	Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9	In vitro activity of ceftobiprole against pathogens from two phase 3 clinical trials of complicated skin and skin structure infections.
AID276293	Antibacterial activity against methicillin-resistant Staphylococcus aureus 20631 at 256 ug/ml	2006	Bioorganic & medicinal chemistry letters, Nov-15, Volume: 16, Issue:22	Solid-phase synthesis and antibacterial activity of hydroxycinnamic acid amides and analogues against methicillin-resistant Staphylococcus aureus and vancomycin-resistant S. aureus.
AID1759657	Antimicrobial activity against against methicillin-resistant Staphylococcus aureus clinical isolate 1089106 by CLSI-based broth microdilution assay	2021	European journal of medicinal chemistry, Jul-05, Volume: 219	4-4-(Anilinomethyl)-3-[4-(trifluoromethyl)phenyl]-1H-pyrazol-1-ylbenzoic acid derivatives as potent anti-gram-positive bacterial agents.
AID1517075	Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC 19047 assessed as reduction in bacterial growth incubated for 24 hrs by serial dilution method	2019	European journal of medicinal chemistry, Dec-01, Volume: 183	Two optimized antimicrobial peptides with therapeutic potential for clinical antibiotic-resistant Staphylococcus aureus.
AID612540	Binding affinity to human PepT2 in SKTP cells	2011	Bioorganic & medicinal chemistry, Aug-01, Volume: 19, Issue:15	Fragmental modeling of hPepT2 and analysis of its binding features by docking studies and pharmacophore mapping.
AID432987	Antimicrobial activity against SCCmec type 1 methicillin-resistant Staphylococcus aureus COL RUSA11-T3 expressing symporter gene smr1 at 37 degC incubated for 24 hrs by E-test	2008	Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2	Role of a sodium-dependent symporter homologue in the thermosensitivity of beta-lactam antibiotic resistance and cell wall composition in Staphylococcus aureus.
AID717274	Antimicrobial activity against methicillin-resistant Staphylococcus aureus ATCC 33591 by CLSI protocol based broth microdilution method	2012	Bioorganic & medicinal chemistry letters, Dec-01, Volume: 22, Issue:23	Antibacterial activity of substituted 5-methylbenzo[c]phenanthridinium derivatives.
AID1242587	Antibacterial activity against methicillin-resistant Staphylococcus aureus R304 clinical isolate after 20 to 24 hrs by CLSI method	2015	ACS medicinal chemistry letters, Jul-09, Volume: 6, Issue:7	Triazole-Linked Glycolipids Enhance the Susceptibility of MRSA to β-Lactam Antibiotics.
AID495797	Activity at Pseudomonas fluorescens PF-1 beta-lactamase BIC-1 expressed in Escherichia coli DH10B carrying pSau1	2010	Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1	Novel ambler class A carbapenem-hydrolyzing beta-lactamase from a Pseudomonas fluorescens isolate from the Seine River, Paris, France.
AID528535	Antimicrobial activity against penicillin-resistant Streptococcus agalactiae B513 by agar dilution method	2008	Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8	First molecular characterization of group B streptococci with reduced penicillin susceptibility.
AID540209	Volume of distribution at steady state in human after iv administration	2008	Drug metabolism and disposition: the biological fate of chemicals, Jul, Volume: 36, Issue:7	Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
AID1767656	Antibacterial activity against Staphylococcus aureus ATCC 29213 assessed as inhibition of bacterial growth incubated for 24 hrs by microdilution assay	2021	Bioorganic & medicinal chemistry letters, 09-01, Volume: 47	Antimicrobial, modulatory, and antibiofilm activity of tt-farnesol on bacterial and fungal strains of importance to human health.
AID501194	Antimicrobial activity against Escherichia coli 442 at 1 unit after 18 hrs by agar diffusion method	2009	Journal of natural products, Oct, Volume: 72, Issue:10	Norselic acids A-E, highly oxidized anti-infective steroids that deter mesograzer predation, from the Antarctic sponge Crella sp.
AID545972	Antimicrobial activity against methicillin-resistant Staphylococcus aureus 16683 by broth dilution method	2010	Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8	Identification of a novel transposon (Tn6072) and a truncated staphylococcal cassette chromosome mec element in methicillin-resistant Staphylococcus aureus ST239.
AID548257	Antibacterial activity against vancomycin-susceptible Staphylococcus aureus Mu50omega expressing vraSm, graRm mutant gene after 24 hrs by Etest	2009	Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3	Contribution of vraSR and graSR point mutations to vancomycin resistance in vancomycin-intermediate Staphylococcus aureus.
AID1294684	Antimicrobial activity against methicillin-resistant Staphylococcus aureus isolate 30a after 24 hrs by agar plate dilution method	2016	European journal of medicinal chemistry, Jun-10, Volume: 115	Anti-methicillin resistant Staphylococcus aureus activity, synergism with oxacillin and molecular docking studies of metronidazole-triazole hybrids.
AID1853614	Antibacterial activity against Staphylococcus aureus clinical isolate 1088105 assessed as inhibition of bacterial growth by CLSI protocol based broth microdilution method	2021	RSC medicinal chemistry, Oct-20, Volume: 12, Issue:10	Design, synthesis, and antibacterial activity of
AID1330197	Antibacterial activity against quinolone-resistant Staphylococcus aureus 3519 measured after 24 hrs by two-fold serial dilution method	2016	Bioorganic & medicinal chemistry letters, 12-15, Volume: 26, Issue:24	Synthesis and biological evaluation of chalcone derivatives containing aminoguanidine or acylhydrazone moieties.
AID565754	Antimicrobial activity against oxacillin-susceptible Staphylococcus haemolyticus clinical isolates by broth microdilution method	2009	Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11	Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates.
AID278909	Antibacterial activity against vancomycin-intermediate methicillin-resistant Staphylococcus aureus	2007	Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1	In vitro antibacterial activity of the pyrrolopyrazolyl-substituted oxazolidinone RWJ-416457.
AID529133	Antimicrobial activity against methicillin-resistant Staphylococcus aureus BK2464 assessed as concentration required for minimum inhibition of oxacillin-resistant subpopulation growth by Etest	2008	Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8	Comparative study of the susceptibilities of major epidemic clones of methicillin-resistant Staphylococcus aureus to oxacillin and to the new broad-spectrum cephalosporin ceftobiprole.
AID561076	Antibacterial activity against community-acquired methicillin-resistant Staphylococcus aureus by CLSI M7-A7 broth microdilution method	2009	Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8	In vitro activity of TR-700, the active ingredient of the antibacterial prodrug TR-701, a novel oxazolidinone antibacterial agent.
AID574296	Antimicrobial activity against community-acquired pbp4-deficient Staphylococcus aureus MW2 ex serotype USA400 by microdilution method	2008	Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11	Staphylococcus aureus PBP4 is essential for beta-lactam resistance in community-acquired methicillin-resistant strains.
AID750305	Bactericidal activity against Staphylococcus aureus isolate C8 derived from naso-pharynx after 18 hrs by broth microdilution method	2013	European journal of medicinal chemistry, Jun, Volume: 64	Synthesis and evaluation of antimicrobial activity of hydrazones derived from 3-oxido-1H-imidazole-4-carbohydrazides.
AID1567123	Antimicrobial activity against Enterobacter cloacae ATCC 13047 incubated for 20 hrs by microdilution method	2019	European journal of medicinal chemistry, Sep-15, Volume: 178	Design, synthesis and biological evaluation of antimicrobial diarylimine and -amine compounds targeting the interaction between the bacterial NusB and NusE proteins.
AID553679	Ratio of intracellular to extracellular drug level in human THP1 cells at 250 mg/L after 24 hrs	2008	Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8	Restoration of susceptibility of intracellular methicillin-resistant Staphylococcus aureus to beta-lactams: comparison of strains, cells, and antibiotics.
AID531572	Antibacterial activity against Streptococcus mitis obtained from complicated skin and skin structure infections by agar dilution method	2008	Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9	In vitro activity of ceftobiprole against pathogens from two phase 3 clinical trials of complicated skin and skin structure infections.
AID637195	Antibacterial activity against Staphylococcus aureus KCTC 503 after 20 hrs by twofold serial dilution technique	2012	European journal of medicinal chemistry, Feb, Volume: 48	Synthesis of novel 1,3-diaryl pyrazole derivatives bearing rhodanine-3-fatty acid moieties as potential antibacterial agents.
AID570772	Antimicrobial activity against community-acquired pbp4-deficient Staphylococcus aureus MW2 serotype USA400 by microdilution method relative to wild type	2008	Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11	Staphylococcus aureus PBP4 is essential for beta-lactam resistance in community-acquired methicillin-resistant strains.
AID1853616	Antibacterial activity against Staphylococcus aureus clinical isolate 1088064 assessed as inhibition of bacterial growth by CLSI protocol based broth microdilution method	2021	RSC medicinal chemistry, Oct-20, Volume: 12, Issue:10	Design, synthesis, and antibacterial activity of
AID1304323	Antibacterial activity against methicillin-resistant Staphylococcus aureus USA300 SF8300 assessed as zone of inhibition at 1 ug after 18 hrs by disk diffusion method	2016	Bioorganic & medicinal chemistry letters, 07-01, Volume: 26, Issue:13	Caged xanthones: Potent inhibitors of global predominant MRSA USA300.
AID1601854	Antibacterial activity against multidrug-resistant Pseudomonas aeruginosa ATCC BAA-2111 measured after 24 hrs by ELISA	2019	European journal of medicinal chemistry, Mar-15, Volume: 166	Synthesis, antimicrobial and cytotoxic activities, and molecular docking studies of N-arylsulfonylindoles containing an aminoguanidine, a semicarbazide, and a thiosemicarbazide moiety.
AID1870143	Antibacterial activity against wild type Staphylococcus aureus 4862/C assessed as reduction in microbial growth incubated for 24 hrs by microdilution assay	2022	Journal of medicinal chemistry, 07-28, Volume: 65, Issue:14	LEGO-Lipophosphonoxins: A Novel Approach in Designing Membrane Targeting Antimicrobials.
AID584472	Antibacterial activity against mecA-negative Staphylococcus vitulinus SVMN02 by agar dilution method	2010	Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10	Origin and molecular evolution of the determinant of methicillin resistance in staphylococci.
AID581665	Antibacterial activity against Staphylococcus aureus SCV isolated from cystic fibrosis patient in cation-adjusted MH 2 broth assessed as log reduction of extracellular CFU level at up to 10'5 times MIC after 24 hrs	2009	Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4	Intracellular activity of antibiotics in a model of human THP-1 macrophages infected by a Staphylococcus aureus small-colony variant strain isolated from a cystic fibrosis patient: pharmacodynamic evaluation and comparison with isogenic normal-phenotype a
AID278672	Antibacterial activity against methicillin-resistant Staphylococcus aureus isolate 5733	2007	Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1	High-level vancomycin-resistant Staphylococcus aureus isolates associated with a polymicrobial biofilm.
AID66284	Inhibition of growth of Enterococcus faecalis OC 3041.	2001	Bioorganic & medicinal chemistry letters, Jun-18, Volume: 11, Issue:12	Amidino benzimidazole inhibitors of bacterial two-component systems.
AID560518	Antimicrobial activity against SCCmec type III vancomycin-intermediate Staphylococcus aureus isolate 15b52 by agar dilution method	2009	Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9	Prevalence and characterization of heterogeneous vancomycin-intermediate Staphylococcus aureus isolates from 14 cities in China.
AID667564	Antibacterial activity against quinolone-resistant Staphylococcus aureus CCARM 3505 after 24 hrs by two-fold serial dilution method	2012	European journal of medicinal chemistry, Aug, Volume: 54	Synthesis and bioactivity evaluation of rhodanine derivatives as potential anti-bacterial agents.
AID544603	Effect on growth of mecA-negative Staphylococcus aureus isolate 29213 by assessed as highest compound concentration at which cell growth occurred measured after 48 hrs	2008	Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11	In vitro and in vivo evaluations of oxacillin efficiency against mecA-positive oxacillin-susceptible Staphylococcus aureus.
AID285361	Increase in Panton-Valentine leukocidin level in community acquired methicillin-resistant Staphylococcus aureus HT20040332 in CYY medium	2007	Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4	Effect of antibiotics on Staphylococcus aureus producing Panton-Valentine leukocidin.
AID1567121	Antimicrobial activity against Acinetobacter baumannii ATCC 19606 incubated for 20 hrs by microdilution method	2019	European journal of medicinal chemistry, Sep-15, Volume: 178	Design, synthesis and biological evaluation of antimicrobial diarylimine and -amine compounds targeting the interaction between the bacterial NusB and NusE proteins.
AID1517081	Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC 19102 assessed as reduction in bacterial growth incubated for 24 hrs by serial dilution method	2019	European journal of medicinal chemistry, Dec-01, Volume: 183	Two optimized antimicrobial peptides with therapeutic potential for clinical antibiotic-resistant Staphylococcus aureus.
AID405472	Antibacterial activity against oxacillin-dependent methicillin-resistant Staphylococcus aureus 2884D isolate	2007	Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7	Identification and phenotypic characterization of a beta-lactam-dependent, methicillin-resistant Staphylococcus aureus strain.
AID559053	Antibacterial activity against Staphylococcus warneri by CLSI M100-S18 method	2009	Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8	Besifloxacin, a novel fluoroquinolone, has broad-spectrum in vitro activity against aerobic and anaerobic bacteria.
AID625285	Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for hepatic necrosis	2011	PLoS computational biology, Dec, Volume: 7, Issue:12	Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
AID545961	Antimicrobial activity against methicillin-resistant Staphylococcus aureus 16680 by broth dilution method	2010	Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8	Identification of a novel transposon (Tn6072) and a truncated staphylococcal cassette chromosome mec element in methicillin-resistant Staphylococcus aureus ST239.
AID529284	Antimicrobial activity against vancomycin-intermediate Staphylococcus aureus Mu50 by Etest	2008	Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8	Comparative study of the susceptibilities of major epidemic clones of methicillin-resistant Staphylococcus aureus to oxacillin and to the new broad-spectrum cephalosporin ceftobiprole.
AID529127	Antimicrobial activity against methicillin-resistant Staphylococcus aureus HAR22 assessed as concentration required for bacterial subpopulation growth	2008	Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8	Comparative study of the susceptibilities of major epidemic clones of methicillin-resistant Staphylococcus aureus to oxacillin and to the new broad-spectrum cephalosporin ceftobiprole.
AID559504	Antibacterial activity against Staphylococcus haemolyticus assessed as percent susceptible isolates by CLSI M100-S18 method	2009	Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8	Besifloxacin, a novel fluoroquinolone, has broad-spectrum in vitro activity against aerobic and anaerobic bacteria.
AID278913	Antibacterial activity against methicillin-susceptible coagulase-negative staphylococci	2007	Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1	In vitro antibacterial activity of the pyrrolopyrazolyl-substituted oxazolidinone RWJ-416457.
AID276292	Antibacterial activity against methicillin-resistant Staphylococcus aureus 20630 at 256 ug/ml	2006	Bioorganic & medicinal chemistry letters, Nov-15, Volume: 16, Issue:22	Solid-phase synthesis and antibacterial activity of hydroxycinnamic acid amides and analogues against methicillin-resistant Staphylococcus aureus and vancomycin-resistant S. aureus.
AID525589	Antimicrobial activity against Macrococcus caseolyticus ATCC 29750 by agar dilution method	2010	Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4	Staphylococcal cassette chromosome mec-like element in Macrococcus caseolyticus.
AID405585	Induction of blaI mRNA expression in oxacillin-dependent methicillin-resistant Staphylococcus aureus 2884D isolate by RT-PCR	2007	Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7	Identification and phenotypic characterization of a beta-lactam-dependent, methicillin-resistant Staphylococcus aureus strain.
AID405481	Effect on blaZ gene expression in oxacillin-dependent methicillin-resistant Staphylococcus aureus 2884D isolate at 0.5 ug/ml in presence of blood agar by RT-PCR	2007	Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7	Identification and phenotypic characterization of a beta-lactam-dependent, methicillin-resistant Staphylococcus aureus strain.
AID637227	Antibacterial activity against quinolone-resistant Staphylococcus aureus CCARM 3505 after 20 hrs by twofold serial dilution technique	2012	European journal of medicinal chemistry, Feb, Volume: 48	Synthesis of novel 1,3-diaryl pyrazole derivatives bearing rhodanine-3-fatty acid moieties as potential antibacterial agents.
AID278665	Antibacterial activity against methicillin-resistant Staphylococcus aureus isolate 5737	2007	Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1	High-level vancomycin-resistant Staphylococcus aureus isolates associated with a polymicrobial biofilm.
AID565008	Antimicrobial activity against methicillin-susceptible coagulase-negative Staphylococcus haemolyticus after 24 hrs by broth microdilution method	2009	Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10	In vitro activities of panduratin A against clinical Staphylococcus strains.
AID553670	Chemical stability of the compound assessed as compound remaining after 24 hrs PBS buffer by HPLC analysis at pH 5.5	2008	Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8	Restoration of susceptibility of intracellular methicillin-resistant Staphylococcus aureus to beta-lactams: comparison of strains, cells, and antibiotics.
AID1524629	Antibacterial activity against quinolone-resistant Staphylococcus aureus CCARM 3519 after 24 hrs by microtiter ELISA	2019	Bioorganic & medicinal chemistry letters, 05-01, Volume: 29, Issue:9	Synthesis of novel dihydrotriazine derivatives bearing 1,3-diaryl pyrazole moieties as potential antibacterial agents.
AID325160	Antimicrobial activity against Escherichia coli pB1000 expressing ROB1 beta lactamase	2007	Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6	Beta-lactam resistance in Haemophilus parasuis Is mediated by plasmid pB1000 bearing blaROB-1.
AID1517074	Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC 19041 assessed as reduction in bacterial growth incubated for 24 hrs by serial dilution method	2019	European journal of medicinal chemistry, Dec-01, Volume: 183	Two optimized antimicrobial peptides with therapeutic potential for clinical antibiotic-resistant Staphylococcus aureus.
AID207671	Minimum inhibitory activity against Staphylococcus aureus MRSA OC2089.	1998	Journal of medicinal chemistry, Jul-30, Volume: 41, Issue:16	Substituted salicylanilides as inhibitors of two-component regulatory systems in bacteria.
AID574295	Antimicrobial activity against community-acquired pbp3-deficient Staphylococcus aureus MW2 ex serotype USA400 by microdilution method	2008	Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11	Staphylococcus aureus PBP4 is essential for beta-lactam resistance in community-acquired methicillin-resistant strains.
AID544600	Effect on growth of Staphylococcus aureus isolate 4666 assessed as highest compound concentration at which cell growth occurred measured after 48 hrs	2008	Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11	In vitro and in vivo evaluations of oxacillin efficiency against mecA-positive oxacillin-susceptible Staphylococcus aureus.
AID404953	Antibacterial activity against methicillin-susceptible coagulase-negative Staphylococcus sp. assessed as percent resistant isolates by CLSI dilution method	2007	Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7	In vitro activities of CG400549, a novel FabI inhibitor, against recently isolated clinical staphylococcal strains in Korea.
AID561074	Antibacterial activity against methicillin-susceptible Staphylococcus aureus by CLSI M7-A7 broth microdilution method	2009	Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8	In vitro activity of TR-700, the active ingredient of the antibacterial prodrug TR-701, a novel oxazolidinone antibacterial agent.
AID564805	Antimicrobial activity against methicillin-resistant Staphylococcus aureus after 24 hrs by broth microdilution method	2009	Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10	In vitro activities of panduratin A against clinical Staphylococcus strains.
AID542613	Antimicrobial activity against Streptococcus pneumoniae R6 harboring PBP2x T338A mutant gene after 48 hrs by agar dilution method	2009	Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3	An important site in PBP2x of penicillin-resistant clinical isolates of Streptococcus pneumoniae: mutational analysis of Thr338.
AID533119	Antimicrobial activity against Staphylococcus aureus 10*3d1-10 by Etest method	2008	Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12	Serial daptomycin selection generates daptomycin-nonsusceptible Staphylococcus aureus strains with a heterogeneous vancomycin-intermediate phenotype.
AID576138	Antibacterial activity against 10'4 to 10'5 CFU methicillin-resistant coagulase-negative Staphylococcus after 18 hrs by CLSI 2-fold agar dilution method	2010	Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12	In vitro and in vivo activities of LCB01-0371, a new oxazolidinone.
AID431096	Antibacterial activity against vancomycin-susceptible Staphylococcus aureus N315 harboring mutated graR gene after 24 hrs by agar dilution method	2008	Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1	Mutated response regulator graR is responsible for phenotypic conversion of Staphylococcus aureus from heterogeneous vancomycin-intermediate resistance to vancomycin-intermediate resistance.
AID570775	Antimicrobial activity against community-acquired pbp3/4-deficient Staphylococcus aureus MW2 ex serotype USA400 by microdilution method relative to wild type	2008	Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11	Staphylococcus aureus PBP4 is essential for beta-lactam resistance in community-acquired methicillin-resistant strains.
AID750319	Antibacterial activity against Staphylococcus aureus isolate C4 derived from naso-pharynx assessed as growth inhibition after 18 hrs by broth microdilution method	2013	European journal of medicinal chemistry, Jun, Volume: 64	Synthesis and evaluation of antimicrobial activity of hydrazones derived from 3-oxido-1H-imidazole-4-carbohydrazides.
AID1869525	Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC33591 measured after 24 hrs by broth microdilution method
AID529126	Antimicrobial activity against methicillin-resistant Staphylococcus aureus HAR24 assessed as concentration required for bacterial subpopulation growth	2008	Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8	Comparative study of the susceptibilities of major epidemic clones of methicillin-resistant Staphylococcus aureus to oxacillin and to the new broad-spectrum cephalosporin ceftobiprole.
AID577442	Antimicrobial activity against Staphylococcus aureus USA300 isolate harboring pSK41 plasmid assessed resistant isolates	2010	Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9	Emergence of resistance among USA300 methicillin-resistant Staphylococcus aureus isolates causing invasive disease in the United States.
AID1438617	Antibacterial activity against Staphylococcus aureus ATCC 25923 after 18 hrs by broth microdilution assay	2017	European journal of medicinal chemistry, Mar-10, Volume: 128	Synthesis, surfactant properties and antimicrobial activities of methyl glycopyranoside ethers.
AID340887	Antimicrobial activity against Escherichia coli JM83 harboring pACYC184-ATEM by serial dilution method	2007	Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8	Cytoplasmic-membrane anchoring of a class A beta-lactamase and its capacity in manifesting antibiotic resistance.
AID432969	Antimicrobial activity against SCCmec type 4 methicillin-resistant Staphylococcus aureus COL MW2 expressing symporter gene smr1 at 37 degC incubated for 24 hrs by E-test	2008	Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2	Role of a sodium-dependent symporter homologue in the thermosensitivity of beta-lactam antibiotic resistance and cell wall composition in Staphylococcus aureus.
AID432978	Antimicrobial activity against SCCmec type 1 methicillin-resistant Staphylococcus aureus COL 319 expressing symporter gene smr1 at 42 degC incubated for 24 hrs by E-test	2008	Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2	Role of a sodium-dependent symporter homologue in the thermosensitivity of beta-lactam antibiotic resistance and cell wall composition in Staphylococcus aureus.
AID285507	Antibacterial activity against methicillin-resistant Staphylococcus aureus after 24 hrs by broth microdilution method	2007	Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4	In vitro and in vivo antibacterial activities of heteroaryl isothiazolones against resistant gram-positive pathogens.
AID1055341	Antibacterial activity against methicillin-resistant Staphylococcus aureus 09-13 assessed as growth inhibition after 18 hrs by agar dilution method	2013	Journal of natural products, Nov-22, Volume: 76, Issue:11	Identification of elaiophylin derivatives from the marine-derived actinomycete Streptomyces sp. 7-145 using PCR-based screening.
AID544604	Effect on growth of Staphylococcus aureus isolate 1326 assessed as highest compound concentration at which cell growth occurred measured after 48 hrs in presence of 2% NaCl	2008	Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11	In vitro and in vivo evaluations of oxacillin efficiency against mecA-positive oxacillin-susceptible Staphylococcus aureus.
AID761563	Antibacterial activity against Staphylococcus aureus Giorgio by M07-A9 CLSI method	2013	Bioorganic & medicinal chemistry letters, Aug-01, Volume: 23, Issue:15	Synthesis and antimicrobial activity of imidazole and pyridine appended cholestane-based conjugates.
AID533933	Antimicrobial activity against linezolid-resistant methicillin-resistant Staphylococcus aureus NRS271 harboring G2576U mutation in peptidyl transferase centre by broth microdilution method	2008	Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12	In vitro activity of TR-700, the antibacterial moiety of the prodrug TR-701, against linezolid-resistant strains.
AID533937	Antimicrobial activity against linezolid-resistant Staphylococcus aureus ATCC 29213 by broth microdilution method	2008	Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12	In vitro activity of TR-700, the antibacterial moiety of the prodrug TR-701, against linezolid-resistant strains.
AID565757	Antimicrobial activity against oxacillin-susceptible Staphylococcus epidermidis clinical isolates by broth microdilution method	2009	Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11	Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates.
AID1601847	Antibacterial activity against Escherichia coli CMCC 25922 measured after 24 hrs by ELISA	2019	European journal of medicinal chemistry, Mar-15, Volume: 166	Synthesis, antimicrobial and cytotoxic activities, and molecular docking studies of N-arylsulfonylindoles containing an aminoguanidine, a semicarbazide, and a thiosemicarbazide moiety.
AID1759655	Antimicrobial activity against against methicillin-resistant Staphylococcus aureus clinical isolate 1088610 by CLSI-based broth microdilution assay	2021	European journal of medicinal chemistry, Jul-05, Volume: 219	4-4-(Anilinomethyl)-3-[4-(trifluoromethyl)phenyl]-1H-pyrazol-1-ylbenzoic acid derivatives as potent anti-gram-positive bacterial agents.
AID548129	Antibacterial activity against Streptococcus mutans KCTC 3065 after 20 hrs by twofold serial dilution technique	2010	European journal of medicinal chemistry, Dec, Volume: 45, Issue:12	Synthesis of new chalcone derivatives containing a rhodanine-3-acetic acid moiety with potential anti-bacterial activity.
AID1732054	Antibacterial activity against Staphylococcus aureus INA 00761	2021	European journal of medicinal chemistry, Apr-05, Volume: 215	Discovery of novel N
AID637228	Antibacterial activity against quinolone-resistant Staphylococcus aureus CCARM 3519 after 20 hrs by twofold serial dilution technique	2012	European journal of medicinal chemistry, Feb, Volume: 48	Synthesis of novel 1,3-diaryl pyrazole derivatives bearing rhodanine-3-fatty acid moieties as potential antibacterial agents.
AID1651736	Antibacterial activity against Vancomycin resistant Enterococcus faecalis MB51 after 24 hrs by microdilution assay	2020	Journal of natural products, 04-24, Volume: 83, Issue:4	Antibacterial and ATP Synthesis Modulating Compounds from
AID529139	Antimicrobial activity against methicillin-resistant Staphylococcus aureus COL assessed as concentration required for minimum inhibition of oxacillin-resistant subpopulation growth by Etest	2008	Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8	Comparative study of the susceptibilities of major epidemic clones of methicillin-resistant Staphylococcus aureus to oxacillin and to the new broad-spectrum cephalosporin ceftobiprole.
AID609220	Antibacterial activity against 10'5 CFU/mL Staphylococcus aureus KCTC 503 assessed as inhibition of bacterial growth after 24 hrs by microtiter enzyme-linked immunosorbent assay	2011	European journal of medicinal chemistry, Aug, Volume: 46, Issue:8	Synthesis of new chalcone derivatives bearing 2,4-thiazolidinedione and benzoic acid moieties as potential anti-bacterial agents.
AID693710	Antibacterial activity against methicillin-resistant Staphylococcus aureus CCARM 3506 after 20 hrs by two fold serial dilution assay	2012	European journal of medicinal chemistry, Dec, Volume: 58	Synthesis and antibacterial activity of novel 1,3-diphenyl-1H-pyrazoles functionalized with phenylalanine-derived rhodanines.
AID528494	Antimicrobial activity against high level levofloxacin and methicillin-resistant Staphylococcus aureus JCSC 6763 expressing gyrA Ser84Leu/Ser85Pro and grlA Ser80Phe/Glu84Lys mutants by broth microdilution method	2008	Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8	Postantibiotic effects and bactericidal activities of levofloxacin and gatifloxacin at concentrations simulating those of topical ophthalmic administration against fluoroquinolone-resistant and fluoroquinolone-sensitive methicillin-resistant Staphylococcu
AID564834	Antimicrobial activity against methicillin-susceptible coagulase-negative Staphylococcus hominis assessed as susceptible isolates after 24 hrs by broth microdilution method	2009	Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10	In vitro activities of panduratin A against clinical Staphylococcus strains.
AID396028	Antibacterial activity against drug-resistant AcrAB-TolC efflux pump deficient Enterobacter cloacae EcdeltaacrA isolate by Etest	2007	Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9	Cloning, nucleotide sequencing, and analysis of the AcrAB-TolC efflux pump of Enterobacter cloacae and determination of its involvement in antibiotic resistance in a clinical isolate.
AID544599	Effect on growth of Staphylococcus aureus isolate 1552 assessed as highest compound concentration at which cell growth occurred measured after 48 hrs	2008	Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11	In vitro and in vivo evaluations of oxacillin efficiency against mecA-positive oxacillin-susceptible Staphylococcus aureus.
AID1294656	Antimicrobial activity against methicillin-resistant Staphylococcus aureus isolate 1a after 24 hrs by agar plate dilution method	2016	European journal of medicinal chemistry, Jun-10, Volume: 115	Anti-methicillin resistant Staphylococcus aureus activity, synergism with oxacillin and molecular docking studies of metronidazole-triazole hybrids.
AID509045	Antibacterial activity against beta-lactamase positive SCCmec type 2 methicillin-resistant Staphylococcus aureus isolate 11218 by broth microdilution method	2010	Antimicrobial agents and chemotherapy, Feb, Volume: 54, Issue:2	Effects of ceftobiprole and oxacillin on mecA expression in methicillin-resistant Staphylococcus aureus clinical isolates.
AID562396	Antimicrobial activity against oxacillin-resistant Staphylococcus aureus clinical isolates assessed as percent susceptible isolates by broth microdilution method	2009	Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11	Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates.
AID565758	Antimicrobial activity against Staphylococcus epidermidis clinical isolates by broth microdilution method	2009	Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11	Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates.
AID1067070	Antimicrobial activity against quinolone-resistant Staphylococcus aureus clinical isolate 3505 after 20 hrs by two-fold serial dilution technique	2014	European journal of medicinal chemistry, Mar-03, Volume: 74	Synthesis and evaluation of the antimicrobial activities of 3-((5-phenyl-1,3,4-oxadiazol-2-yl)methyl)-2-thioxothiazolidin-4-one derivatives.
AID559051	Antibacterial activity against Staphylococcus lugdunensis by CLSI M100-S18 method	2009	Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8	Besifloxacin, a novel fluoroquinolone, has broad-spectrum in vitro activity against aerobic and anaerobic bacteria.
AID524391	Antibacterial activity against Escherichia coli NKE1368 harboring deletion mutation in acrB, acrD and vector expressing mdtABC gene	2010	Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5	Effect of NlpE overproduction on multidrug resistance in Escherichia coli.
AID625289	Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for liver disease	2011	PLoS computational biology, Dec, Volume: 7, Issue:12	Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
AID511381	Antibacterial activity against methicillin resistant coagulase negative Staphylococcus epidermidis by broth dilution method	2010	Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3	Comparative in vitro activities of nemonoxacin (TG-873870), a novel nonfluorinated quinolone, and other quinolones against clinical isolates.
AID1567137	Antimicrobial activity against CA-methicillin-resistant Staphylococcus aureus W4 ST338 incubated for 20 hrs by microdilution method	2019	European journal of medicinal chemistry, Sep-15, Volume: 178	Design, synthesis and biological evaluation of antimicrobial diarylimine and -amine compounds targeting the interaction between the bacterial NusB and NusE proteins.
AID750304	Bactericidal activity against Staphylococcus aureus isolate C19 derived from naso-pharynx after 18 hrs by broth microdilution method	2013	European journal of medicinal chemistry, Jun, Volume: 64	Synthesis and evaluation of antimicrobial activity of hydrazones derived from 3-oxido-1H-imidazole-4-carbohydrazides.
AID524393	Antibacterial activity against Escherichia coli NKE1359 harboring deletion mutation in acrB protein and plasmid expressing BADnlpE gene in presence of increasing concentration of arabinose	2010	Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5	Effect of NlpE overproduction on multidrug resistance in Escherichia coli.
AID520725	Activity of Acinetobacter baumannii MAD beta-lactamase assessed per mg of protein at 100 uM	2008	Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5	Carbapenem-resistant Acinetobacter baumannii isolates from Tunisia producing the OXA-58-like carbapenem-hydrolyzing oxacillinase OXA-97.
AID531577	Antibacterial activity against Gemella spp. obtained from complicated skin and skin structure infections by agar dilution method	2008	Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9	In vitro activity of ceftobiprole against pathogens from two phase 3 clinical trials of complicated skin and skin structure infections.
AID285342	Antibacterial activity against community acquired methicillin-resistant Staphylococcus aureus HT20020488 in Mueller-Hinton medium	2007	Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4	Effect of antibiotics on Staphylococcus aureus producing Panton-Valentine leukocidin.
AID543065	Antibacterial activity against methicillin-resistant Staphylococcus aureus ST398	2009	Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2	Identification of a novel trimethoprim resistance gene, dfrK, in a methicillin-resistant Staphylococcus aureus ST398 strain and its physical linkage to the tetracycline resistance gene tet(L).
AID1294716	Bactericidal activity against methicillin-resistant Staphylococcus aureus isolate 1a assessed as reduction in colony counts at 32 ug/ml after 8 hrs by pour plate method (Rvb = 8.30 +/- 0.442 log10CFU/ml)	2016	European journal of medicinal chemistry, Jun-10, Volume: 115	Anti-methicillin resistant Staphylococcus aureus activity, synergism with oxacillin and molecular docking studies of metronidazole-triazole hybrids.
AID285941	Antimicrobial activity against methicillin-susceptible Staphylococcus aureus ATCC 29213 in human monocyte-derived macrophages at 5 ug/ml assessed as bacterial viability after 24 hrs	2007	Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4	Antimicrobial activities of daptomycin, vancomycin, and oxacillin in human monocytes and of daptomycin in combination with gentamicin and/or rifampin in human monocytes and in broth against Staphylococcus aureus.
AID1294669	Antimicrobial activity against methicillin-resistant Staphylococcus aureus isolate 15a after 24 hrs by agar plate dilution method	2016	European journal of medicinal chemistry, Jun-10, Volume: 115	Anti-methicillin resistant Staphylococcus aureus activity, synergism with oxacillin and molecular docking studies of metronidazole-triazole hybrids.
AID1853618	Antibacterial activity against Staphylococcus aureus clinical isolate 1088888 assessed as inhibition of bacterial growth by CLSI protocol based broth microdilution method	2021	RSC medicinal chemistry, Oct-20, Volume: 12, Issue:10	Design, synthesis, and antibacterial activity of
AID718547	Antibacterial activity against Escherichia coli 1356 incubated for 24 hrs serial dilution method	2012	Bioorganic & medicinal chemistry letters, Dec-01, Volume: 22, Issue:23	Synthesis and biological evaluation of 5-aryloxypyrazole derivatives bearing a rhodanine-3-aromatic acid as potential antimicrobial agents.
AID559045	Antibacterial activity against ciprofloxacin-susceptible and methicillin-resistant Staphylococcus aureus by CLSI M100-S18 method	2009	Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8	Besifloxacin, a novel fluoroquinolone, has broad-spectrum in vitro activity against aerobic and anaerobic bacteria.
AID1818975	Antibacterial activity against Staphylococcus aureus ATCC 6538 assessed as bacterial clearance incubated for 6 to 24 hrs by microbroth dilution method	2022	Journal of medicinal chemistry, 01-13, Volume: 65, Issue:1	Discovery of
AID542628	Antimicrobial activity against streptomycin-resistant Streptococcus pneumoniae R6 harboring PBP2x2349 mutant gene and Janus disruption at PBP1a and aad9 disruption in CiaR gene after 48 hrs by agar dilution method	2009	Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3	An important site in PBP2x of penicillin-resistant clinical isolates of Streptococcus pneumoniae: mutational analysis of Thr338.
AID726565	Antibacterial activity against methicillin-resistant Staphylococcus aureus CCARM 3167 assessed as bacterial growth inhibition measured during 24 hrs incubation at 37 degC by two-fold serial dilution technique	2013	European journal of medicinal chemistry, Feb, Volume: 60	Synthesis and antibacterial evaluation of rhodanine-based 5-aryloxy pyrazoles against selected methicillin resistant and quinolone-resistant Staphylococcus aureus (MRSA and QRSA).
AID519457	Antimicrobial activity against heterotypic oxacillin resistant and vancomycin intermediate resistant Staphylococcus aureus isolate 5836 by broth microdilution method	2008	Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4	Spontaneous deletion of the methicillin resistance determinant, mecA, partially compensates for the fitness cost associated with high-level vancomycin resistance in Staphylococcus aureus.
AID431109	Antibacterial activity against heterogeneous vancomycin-intermediate Staphylococcus aureus Mu3 harboring shuttle vector pYT3 after 48 hrs by agar dilution method	2008	Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1	Mutated response regulator graR is responsible for phenotypic conversion of Staphylococcus aureus from heterogeneous vancomycin-intermediate resistance to vancomycin-intermediate resistance.
AID584468	Antibacterial activity against methicillin-resistant mecA-positive Staphylococcus vitulinus SVMP04 by agar dilution method	2010	Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10	Origin and molecular evolution of the determinant of methicillin resistance in staphylococci.
AID405605	Decrease in blaZ gene expression in oxacillin-dependent methicillin-resistant Staphylococcus aureus 2884D isolate at 0.5 ug/ml by microarray-based transcriptional profiling relative to control	2007	Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7	Identification and phenotypic characterization of a beta-lactam-dependent, methicillin-resistant Staphylococcus aureus strain.
AID584474	Antibacterial activity against mecA-negative Staphylococcus vitulinus SVMN04 by agar dilution method	2010	Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10	Origin and molecular evolution of the determinant of methicillin resistance in staphylococci.
AID718550	Antibacterial activity against Staphylococcus aureus RN 4220 incubated for 24 hrs serial dilution method	2012	Bioorganic & medicinal chemistry letters, Dec-01, Volume: 22, Issue:23	Synthesis and biological evaluation of 5-aryloxypyrazole derivatives bearing a rhodanine-3-aromatic acid as potential antimicrobial agents.
AID564813	Bactericidal activity against methicillin-resistant coagulase-negative Staphylococcus epidermidis after 24 hrs by plate counting method	2009	Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10	In vitro activities of panduratin A against clinical Staphylococcus strains.
AID1551299	Antibacterial activity against Quinolone-resistant Staphylococcus aureus CCARM 3505 assessed as reduction in bacterial cell growth incubated for 24 hrs by ELISA	2019	European journal of medicinal chemistry, Jun-15, Volume: 172	Synthesis and biological evaluation of tryptophan-derived rhodanine derivatives as PTP1B inhibitors and anti-bacterial agents.
AID1438621	Antibacterial activity against methicillin-resistant Staphylococcus aureus isolate LY 1999-0053 after 18 hrs by broth microdilution assay	2017	European journal of medicinal chemistry, Mar-10, Volume: 128	Synthesis, surfactant properties and antimicrobial activities of methyl glycopyranoside ethers.
AID404935	Antibacterial activity against methicillin-susceptible Staphylococcus aureus isolate by CLSI dilution method	2007	Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7	In vitro activities of CG400549, a novel FabI inhibitor, against recently isolated clinical staphylococcal strains in Korea.
AID29812	Oral bioavailability in human	2000	Journal of medicinal chemistry, Jun-29, Volume: 43, Issue:13	QSAR model for drug human oral bioavailability.
AID560503	Antimicrobial activity against SCCmec type II vancomycin-intermediate Staphylococcus aureus isolate 6zjsau7 by agar dilution method	2009	Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9	Prevalence and characterization of heterogeneous vancomycin-intermediate Staphylococcus aureus isolates from 14 cities in China.
AID511305	Antibacterial activity against methicillin resistant coagulase negative Staphylococcus by broth dilution method	2010	Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3	Comparative in vitro activities of nemonoxacin (TG-873870), a novel nonfluorinated quinolone, and other quinolones against clinical isolates.
AID431100	Antibacterial activity against graSR gene knockout vancomycin-susceptible Staphylococcus aureus N315 after 24 hrs by agar dilution method	2008	Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1	Mutated response regulator graR is responsible for phenotypic conversion of Staphylococcus aureus from heterogeneous vancomycin-intermediate resistance to vancomycin-intermediate resistance.
AID1079943	Malignant tumor, proven histopathologically. Value is number of references indexed. [column 'T.MAL' in source]
AID726491	Antibacterial activity against quinolone-resistant Staphylococcus aureus CCARM 3505 assessed as bacterial growth inhibition measured during 24 hrs incubation at 37 degC by two-fold serial dilution technique	2013	European journal of medicinal chemistry, Feb, Volume: 60	Synthesis and antibacterial evaluation of rhodanine-based 5-aryloxy pyrazoles against selected methicillin resistant and quinolone-resistant Staphylococcus aureus (MRSA and QRSA).
AID1230066	Antibacterial activity against methicillin-resistant Staphylococcus aureus GRE2691 assessed as inhibition of bacterial growth	2015	Bioorganic & medicinal chemistry, Jul-01, Volume: 23, Issue:13	Synthesis and antimicrobial activity of chloramphenicol-polyamine conjugates.
AID562397	Antimicrobial activity against oxacillin-susceptible Staphylococcus aureus clinical isolates assessed as percent susceptible isolates by broth microdilution method	2009	Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11	Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates.
AID1869527	Antibacterial activity against Staphylococcus epidermidis ATCC12228 measured after 24 hrs by broth microdilution method
AID575143	Antimicrobial activity against methicillin-resistant Staphylococcus aureus isolate NRS70 by broth microdilution method	2010	Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9	Inhibition of antibiotic-resistant Staphylococcus aureus by the broad-spectrum dihydrofolate reductase inhibitor RAB1.
AID501206	Antimicrobial activity against methicillin sensitive Staphylococcus aureus 375 assessed as hazy zone of inhibition at 1 unit after 18 hrs by agar diffusion method	2009	Journal of natural products, Oct, Volume: 72, Issue:10	Norselic acids A-E, highly oxidized anti-infective steroids that deter mesograzer predation, from the Antarctic sponge Crella sp.
AID573152	Antibacterial activity against vancomycin-resistant Enterococcus faecalis by CLSI M7-A7 broth microdilution method	2008	Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9	In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States.
AID528529	Antimicrobial activity against penicillin-resistant Streptococcus agalactiae B12 by agar dilution method	2008	Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8	First molecular characterization of group B streptococci with reduced penicillin susceptibility.
AID1504824	Antibacterial activity against methicillin-sensitive Staphylococcus aureus ATCC 6358 after 24 hrs by broth microdilution method	2017	Journal of natural products, 12-22, Volume: 80, Issue:12	Sulfur-Containing Aristoloxazines and Other Constituents of the Roots of Aristolochia orbicularis.
AID625286	Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for hepatitis	2011	PLoS computational biology, Dec, Volume: 7, Issue:12	Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
AID574293	Antimicrobial activity against community-acquired pbp4::pbp4-deficient Staphylococcus aureus MW2 serotype USA400 by microdilution method	2008	Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11	Staphylococcus aureus PBP4 is essential for beta-lactam resistance in community-acquired methicillin-resistant strains.
AID1242582	Antibacterial activity against methicillin-resistant Staphylococcus aureus R36 clinical isolate after 20 to 24 hrs by CLSI method	2015	ACS medicinal chemistry letters, Jul-09, Volume: 6, Issue:7	Triazole-Linked Glycolipids Enhance the Susceptibility of MRSA to β-Lactam Antibiotics.
AID573119	Antibacterial activity against coagulase-negative and oxacillin-susceptible Staphylococcus aureus by CLSI M7-A7 broth microdilution method	2008	Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9	In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States.
AID285351	Antibacterial activity against community acquired methicillin-resistant Staphylococcus aureus HT20041010 in CCY media	2007	Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4	Effect of antibiotics on Staphylococcus aureus producing Panton-Valentine leukocidin.
AID739304	Antibacterial activity against vancomycin-sensitive Enterococcus faecalis ATCC 19433 assessed as growth inhibition by CLSI broth microdilution method	2013	Bioorganic & medicinal chemistry letters, Apr-01, Volume: 23, Issue:7	Substituted 1,6-diphenylnaphthalenes as FtsZ-targeting antibacterial agents.
AID667558	Antibacterial activity against Escherichia coli 1356 after 24 hrs by two-fold serial dilution method	2012	European journal of medicinal chemistry, Aug, Volume: 54	Synthesis and bioactivity evaluation of rhodanine derivatives as potential anti-bacterial agents.
AID1504827	Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC 43300 after 24 hrs by broth microdilution method	2017	Journal of natural products, 12-22, Volume: 80, Issue:12	Sulfur-Containing Aristoloxazines and Other Constituents of the Roots of Aristolochia orbicularis.
AID276290	Antibacterial activity against methicillin-resistant Staphylococcus aureus at 256 ug/ml	2006	Bioorganic & medicinal chemistry letters, Nov-15, Volume: 16, Issue:22	Solid-phase synthesis and antibacterial activity of hydroxycinnamic acid amides and analogues against methicillin-resistant Staphylococcus aureus and vancomycin-resistant S. aureus.
AID1438626	Antibacterial activity against daptomycin-resistant Staphylococcus aureus isolate ST 2015-0989 after 18 hrs by broth microdilution assay	2017	European journal of medicinal chemistry, Mar-10, Volume: 128	Synthesis, surfactant properties and antimicrobial activities of methyl glycopyranoside ethers.
AID525584	Antimicrobial activity against multidrug-resistant Macrococcus caseolyticus JCSC7096 containing plasmid pMCCL2 which carries transposon containing (mecA(m)-mecR1(m)-mecI(m)-blaZ(m)) complex isolated from chicken by agar dilution method	2010	Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4	Staphylococcal cassette chromosome mec-like element in Macrococcus caseolyticus.
AID625281	Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for cholelithiasis	2011	PLoS computational biology, Dec, Volume: 7, Issue:12	Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
AID528500	Antimicrobial activity against levofloxacin-sensitive and methicillin-resistant Staphylococcus aureus JCSC 6769 by broth microdilution method	2008	Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8	Postantibiotic effects and bactericidal activities of levofloxacin and gatifloxacin at concentrations simulating those of topical ophthalmic administration against fluoroquinolone-resistant and fluoroquinolone-sensitive methicillin-resistant Staphylococcu
AID431110	Antibacterial activity against heterogeneous vancomycin-intermediate Staphylococcus aureus Mu3 harboring mutated graR gene after 24 hrs by agar dilution method	2008	Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1	Mutated response regulator graR is responsible for phenotypic conversion of Staphylococcus aureus from heterogeneous vancomycin-intermediate resistance to vancomycin-intermediate resistance.
AID571927	Ratio of MIC for Escherichia coli K-12 3-AG300 harboring acrB::rpsLneo mutant gene to MIC for Escherichia coli K-12 3-AG300	2009	Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1	Site-directed mutagenesis reveals amino acid residues in the Escherichia coli RND efflux pump AcrB that confer macrolide resistance.
AID1294679	Antimicrobial activity against methicillin-resistant Staphylococcus aureus isolate 25a after 24 hrs by agar plate dilution method	2016	European journal of medicinal chemistry, Jun-10, Volume: 115	Anti-methicillin resistant Staphylococcus aureus activity, synergism with oxacillin and molecular docking studies of metronidazole-triazole hybrids.
AID694206	Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC 33591 by CLSI broth microdilution method	2012	Bioorganic & medicinal chemistry letters, Nov-15, Volume: 22, Issue:22	Antibacterial activity of substituted dibenzo[a,g]quinolizin-7-ium derivatives.
AID1609333	Antibacterial activity against multidrug-resistant Pseudomonas aeruginosa CCARM 2095 assessed as reduction in bacterial growth incubated for 72 hrs by spectrophotometry	2019	European journal of medicinal chemistry, Nov-15, Volume: 182	The design of a cell-selective fowlicidin-1-derived peptide with both antimicrobial and anti-inflammatory activities.
AID276298	Antibacterial activity against methicillin-resistant Staphylococcus aureus 20652 at 256 ug/ml	2006	Bioorganic & medicinal chemistry letters, Nov-15, Volume: 16, Issue:22	Solid-phase synthesis and antibacterial activity of hydroxycinnamic acid amides and analogues against methicillin-resistant Staphylococcus aureus and vancomycin-resistant S. aureus.
AID402928	Antimicrobial activity against methicillin-resistant Staphylococcus aureus 1 after 24 hrs	2004	Journal of natural products, Jun, Volume: 67, Issue:6	New stilbene derivatives from Calligonum leucocladum.
AID544612	Antibacterial activity against Staphylococcus aureus isolate 2712 assessed as reduction in bacterial count at 20 ug/ml after 24 hrs by time-kill assay	2008	Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11	In vitro and in vivo evaluations of oxacillin efficiency against mecA-positive oxacillin-susceptible Staphylococcus aureus.
AID562395	Antimicrobial activity against Staphylococcus epidermidis clinical isolates assessed as percent susceptible isolates by broth microdilution method	2009	Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11	Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates.
AID1055323	Antibacterial activity against beta-lactamase producing Morganella morganii ATCC 25830 assessed as growth inhibition after 18 hrs by agar dilution method	2013	Journal of natural products, Nov-22, Volume: 76, Issue:11	Identification of elaiophylin derivatives from the marine-derived actinomycete Streptomyces sp. 7-145 using PCR-based screening.
AID324357	Drug level in Staphylococcus aureus infected Wistar rat pups serum at 50 mg/kg, ip	2007	Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6	Lysostaphin in treatment of neonatal Staphylococcus aureus infection.
AID276297	Antibacterial activity against methicillin-resistant Staphylococcus aureus 20636 at 256 ug/ml	2006	Bioorganic & medicinal chemistry letters, Nov-15, Volume: 16, Issue:22	Solid-phase synthesis and antibacterial activity of hydroxycinnamic acid amides and analogues against methicillin-resistant Staphylococcus aureus and vancomycin-resistant S. aureus.
AID529113	Antimicrobial activity against methicillin-resistant Staphylococcus aureus BK2464 by Etest	2008	Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8	Comparative study of the susceptibilities of major epidemic clones of methicillin-resistant Staphylococcus aureus to oxacillin and to the new broad-spectrum cephalosporin ceftobiprole.
AID584994	Antibacterial activity against Staphylococcus aureus XU21-T1 harboring cfr-encoding conjugative pSCFS7 and fexA by broth microdilution method	2010	Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12	Identification and characterization of the multidrug resistance gene cfr in a Panton-Valentine leukocidin-positive sequence type 8 methicillin-resistant Staphylococcus aureus IVa (USA300) isolate.
AID584301	Antibacterial activity against methicillin-resistant mecA-positive Staphylococcus sciuri subsp. carnaticus ATCC 700058T by agar dilution method	2010	Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10	Origin and molecular evolution of the determinant of methicillin resistance in staphylococci.
AID285931	Antimicrobial activity against methicillin-susceptible Staphylococcus aureus ATCC 29213 in human monocyte-derived macrophages at 0.25 ug/ml assessed as bacterial viability after 4 hrs	2007	Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4	Antimicrobial activities of daptomycin, vancomycin, and oxacillin in human monocytes and of daptomycin in combination with gentamicin and/or rifampin in human monocytes and in broth against Staphylococcus aureus.
AID581657	Antibacterial activity against normal phenotype Staphylococcus aureus at pH 7.4 after 24 hrs by broth microdilution method	2009	Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4	Intracellular activity of antibiotics in a model of human THP-1 macrophages infected by a Staphylococcus aureus small-colony variant strain isolated from a cystic fibrosis patient: pharmacodynamic evaluation and comparison with isogenic normal-phenotype a
AID1294655	Antimicrobial activity against methicillin-resistant Staphylococcus aureus isolate 2a after 24 hrs by agar plate dilution method	2016	European journal of medicinal chemistry, Jun-10, Volume: 115	Anti-methicillin resistant Staphylococcus aureus activity, synergism with oxacillin and molecular docking studies of metronidazole-triazole hybrids.
AID739305	Antibacterial activity against methicillin-sensitive Staphylococcus aureus 8325-4 assessed as growth inhibition by CLSI broth microdilution method	2013	Bioorganic & medicinal chemistry letters, Apr-01, Volume: 23, Issue:7	Substituted 1,6-diphenylnaphthalenes as FtsZ-targeting antibacterial agents.
AID693707	Antibacterial activity against Escherichia coli CCARM 1924 after 20 hrs by two fold serial dilution assay	2012	European journal of medicinal chemistry, Dec, Volume: 58	Synthesis and antibacterial activity of novel 1,3-diphenyl-1H-pyrazoles functionalized with phenylalanine-derived rhodanines.
AID405474	Increase in mecA gene expression in methicillin-resistant Staphylococcus aureus 2884 isolate at 0.5 ug/ml by RT-PCR	2007	Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7	Identification and phenotypic characterization of a beta-lactam-dependent, methicillin-resistant Staphylococcus aureus strain.
AID576140	Antibacterial activity against 10'4 to 10'5 CFU methicillin-susceptible coagulase-negative Staphylococcus after 18 hrs by CLSI 2-fold agar dilution method	2010	Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12	In vitro and in vivo activities of LCB01-0371, a new oxazolidinone.
AID559500	Antibacterial activity against ciprofloxacin-susceptible and methicillin-resistant Staphylococcus aureus assessed as percent susceptible isolates by CLSI M100-S18 method	2009	Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8	Besifloxacin, a novel fluoroquinolone, has broad-spectrum in vitro activity against aerobic and anaerobic bacteria.
AID285343	Antibacterial activity against community acquired methicillin-resistant Staphylococcus aureus HT20030203 in Mueller-Hinton medium	2007	Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4	Effect of antibiotics on Staphylococcus aureus producing Panton-Valentine leukocidin.
AID1517070	Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC 18567 assessed as reduction in bacterial growth incubated for 24 hrs by serial dilution method	2019	European journal of medicinal chemistry, Dec-01, Volume: 183	Two optimized antimicrobial peptides with therapeutic potential for clinical antibiotic-resistant Staphylococcus aureus.
AID573115	Antibacterial activity against methicillin-susceptible Staphylococcus aureus assessed as resistant isolates by CLSI M7-A7 broth microdilution method	2008	Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9	In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States.
AID531575	Antibacterial activity against Bacillus spp. obtained from complicated skin and skin structure infections by agar dilution method	2008	Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9	In vitro activity of ceftobiprole against pathogens from two phase 3 clinical trials of complicated skin and skin structure infections.
AID530764	Induction of Ppbp2::lacZ gene expression in Staphylococcus aureus SH1000 at 8 ug/ml after 2 hrs by beta-galactosidase reporter gene assay relative to untreated control	2008	Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8	Staphylococcus aureus cell wall stress stimulon gene-lacZ fusion strains: potential for use in screening for cell wall-active antimicrobials.
AID432988	Antimicrobial activity against SCCmec type 1 methicillin-resistant Staphylococcus aureus COL RUSA11-T3 expressing symporter gene smr1 at 42 degC incubated for 24 hrs by E-test	2008	Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2	Role of a sodium-dependent symporter homologue in the thermosensitivity of beta-lactam antibiotic resistance and cell wall composition in Staphylococcus aureus.
AID750297	Bactericidal activity against Staphylococcus aureus isolate D17 derived from bone after 18 hrs by broth microdilution method	2013	European journal of medicinal chemistry, Jun, Volume: 64	Synthesis and evaluation of antimicrobial activity of hydrazones derived from 3-oxido-1H-imidazole-4-carbohydrazides.
AID1759646	Antimicrobial activity against vancomycin-resistant Enterococcus faecium clinical isolate 1088228 by CLSI-based broth microdilution assay	2021	European journal of medicinal chemistry, Jul-05, Volume: 219	4-4-(Anilinomethyl)-3-[4-(trifluoromethyl)phenyl]-1H-pyrazol-1-ylbenzoic acid derivatives as potent anti-gram-positive bacterial agents.
AID559771	Antimicrobial activity against SCCmec type II vancomycin-intermediate Staphylococcus aureus isolate 4sy39 by agar dilution method	2009	Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9	Prevalence and characterization of heterogeneous vancomycin-intermediate Staphylococcus aureus isolates from 14 cities in China.
AID525582	Ratio of Kcat to Km for Beta-lactamase OXA-1 expressed in Escherichia coli BL21 (DE3)	2010	Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4	Penicillin sulfone inhibitors of class D beta-lactamases.
AID276287	Antibacterial activity against vancomycin-resistant Staphylococcus aureus 20623 at 256 ug/ml	2006	Bioorganic & medicinal chemistry letters, Nov-15, Volume: 16, Issue:22	Solid-phase synthesis and antibacterial activity of hydroxycinnamic acid amides and analogues against methicillin-resistant Staphylococcus aureus and vancomycin-resistant S. aureus.
AID1438625	Antibacterial activity against daptomycin-resistant Staphylococcus aureus isolate ST 2014-1288 after 18 hrs by broth microdilution assay	2017	European journal of medicinal chemistry, Mar-10, Volume: 128	Synthesis, surfactant properties and antimicrobial activities of methyl glycopyranoside ethers.
AID1567118	Antimicrobial activity against Enterococcus faecium ATCC 19433 incubated for 20 hrs by microdilution method	2019	European journal of medicinal chemistry, Sep-15, Volume: 178	Design, synthesis and biological evaluation of antimicrobial diarylimine and -amine compounds targeting the interaction between the bacterial NusB and NusE proteins.
AID544591	Antibacterial activity against Staphylococcus aureus isolate 1326 by agar dilution method	2008	Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11	In vitro and in vivo evaluations of oxacillin efficiency against mecA-positive oxacillin-susceptible Staphylococcus aureus.
AID559081	Antibacterial activity against Moraxella catarrhalis by CLSI M7-A7 method	2009	Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8	Besifloxacin, a novel fluoroquinolone, has broad-spectrum in vitro activity against aerobic and anaerobic bacteria.
AID559046	Antibacterial activity against non-ciprofloxacin-susceptible and methicillin-susceptible Staphylococcus aureus by CLSI M100-S18 method	2009	Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8	Besifloxacin, a novel fluoroquinolone, has broad-spectrum in vitro activity against aerobic and anaerobic bacteria.
AID545964	Antimicrobial activity against methicillin-resistant Staphylococcus aureus 16698 by broth dilution method	2010	Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8	Identification of a novel transposon (Tn6072) and a truncated staphylococcal cassette chromosome mec element in methicillin-resistant Staphylococcus aureus ST239.
AID576139	Antibacterial activity against 10'4 to 10'5 CFU Streptococcus pneumoniae after 18 hrs by CLSI 2-fold agar dilution method	2010	Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12	In vitro and in vivo activities of LCB01-0371, a new oxazolidinone.
AID718413	Antibacterial activity against log-phase vancomycin-resistant Enterococcus faecalis ATCC 51575 assessed as growth inhibition after 24 hrs by broth microdilution method	2012	Bioorganic & medicinal chemistry, Dec-15, Volume: 20, Issue:24	3-Phenyl substituted 6,7-dimethoxyisoquinoline derivatives as FtsZ-targeting antibacterial agents.
AID531562	Antibacterial activity against coagulase-negative Staphylococcus warneri obtained from complicated skin and skin structure infections by agar dilution method	2008	Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9	In vitro activity of ceftobiprole against pathogens from two phase 3 clinical trials of complicated skin and skin structure infections.
AID1763158	Antibacterial activity against methicillin-resistant Staphylococcus aureus 58 assessed as reduction in bacterial growth incubated for 24 hrs by CLSI based serial dilution method	2021	Bioorganic & medicinal chemistry, 05-15, Volume: 38	Antibacterial and synergistic activity of 6β-hydroxy-3-oxolup-20(29)-en-28-oic acid (6β-hydroxy betunolic acid) isolated from Schumacheria castaneifolia vahl.
AID68415	Minimum inhibitory activity against Enterococcus faecium OC3312.	1998	Journal of medicinal chemistry, Jul-30, Volume: 41, Issue:16	Substituted salicylanilides as inhibitors of two-component regulatory systems in bacteria.
AID1079944	Benign tumor, proven histopathologically. Value is number of references indexed. [column 'T.BEN' in source]
AID562600	Antimicrobial activity against oxacillin-resistant Staphylococcus epidermidis clinical isolates assessed as resistant isolates by broth microdilution method	2009	Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11	Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates.
AID431103	Antibacterial activity against mutated graR gene knockout vancomycin-susceptible Staphylococcus aureus N315 after 48 hrs by agar dilution method	2008	Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1	Mutated response regulator graR is responsible for phenotypic conversion of Staphylococcus aureus from heterogeneous vancomycin-intermediate resistance to vancomycin-intermediate resistance.
AID1691358	Antimicrobial activity against methicillin-resistant Staphylococcus aureus CCARM 3089 assessed as reduction in microbial growth incubated for 18 to 24 hrs by broth microdilution method	2020	European journal of medicinal chemistry, May-01, Volume: 193	Antibacterial AZT derivative regulates metastasis of breast cancer cells.
AID564832	Bactericidal activity against methicillin-resistant coagulase-negative Staphylococcus sciuri after 24 hrs by plate counting method	2009	Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10	In vitro activities of panduratin A against clinical Staphylococcus strains.
AID424423	Antibacterial activity against Enterococcus faecalis HIP15179 coisolated with vancomycin-resistant Staphylococcus aureus by broth microdilution method	2008	Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2	Vancomycin-resistant Staphylococcus aureus isolates associated with Inc18-like vanA plasmids in Michigan.
AID667562	Antibacterial activity against methicillin-resistant Staphylococcus aureus CCARM 3167 after 24 hrs by two-fold serial dilution method	2012	European journal of medicinal chemistry, Aug, Volume: 54	Synthesis and bioactivity evaluation of rhodanine derivatives as potential anti-bacterial agents.
AID750335	Bactericidal activity against Staphylococcus aureus ATCC 6538 after 18 hrs by broth microdilution method	2013	European journal of medicinal chemistry, Jun, Volume: 64	Synthesis and evaluation of antimicrobial activity of hydrazones derived from 3-oxido-1H-imidazole-4-carbohydrazides.
AID528530	Antimicrobial activity against penicillin-resistant Streptococcus agalactiae B40 by agar dilution method	2008	Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8	First molecular characterization of group B streptococci with reduced penicillin susceptibility.
AID565019	Bactericidal activity against methicillin-susceptible coagulase-negative Staphylococcus sciuri after 24 hrs by plate counting method	2009	Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10	In vitro activities of panduratin A against clinical Staphylococcus strains.
AID520873	Antibacterial activity against methicillin-resistant mecA-positive Staphylococcus saprophyticus isolate TSU69 isolated from genitourinary tracts of acute cystitis patient after 24 hrs at 35 degC by agar dilution method	2008	Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6	Methicillin-resistant Staphylococcus saprophyticus isolates carrying staphylococcal cassette chromosome mec have emerged in urogenital tract infections.
AID1638996	Antibacterial activity against Staphylococcus aureus ATCC 6538 after 24 hrs by resazurin dye based fluorescence assay	2019	Journal of natural products, 04-26, Volume: 82, Issue:4	Mindapyrroles A-C, Pyoluteorin Analogues from a Shipworm-Associated Bacterium.
AID543954	Antibacterial activity against chloramphenicol-resistant Staphylococcus aureus COL carrying mecI-mecR1 plasmid	2009	Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2	Reconstruction of the phenotypes of methicillin-resistant Staphylococcus aureus by replacement of the staphylococcal cassette chromosome mec with a plasmid-borne copy of Staphylococcus sciuri pbpD gene.
AID761564	Antibacterial activity against Staphylococcus aureus ATCC 25923 by M07-A9 CLSI method	2013	Bioorganic & medicinal chemistry letters, Aug-01, Volume: 23, Issue:15	Synthesis and antimicrobial activity of imidazole and pyridine appended cholestane-based conjugates.
AID565017	Antimicrobial activity against methicillin-susceptible coagulase-negative Staphylococcus sciuri assessed as susceptible isolates after 24 hrs by broth microdilution method	2009	Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10	In vitro activities of panduratin A against clinical Staphylococcus strains.
AID544609	Antibacterial activity against Staphylococcus aureus isolate 4666 assessed as reduction in bacterial count at 20 ug/ml after 24 hrs by time-kill assay	2008	Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11	In vitro and in vivo evaluations of oxacillin efficiency against mecA-positive oxacillin-susceptible Staphylococcus aureus.
AID1870155	Antibacterial activity against wild type Staphylococcus aureus 4502/A assessed as reduction in microbial growth incubated for 24 hrs by microdilution assay	2022	Journal of medicinal chemistry, 07-28, Volume: 65, Issue:14	LEGO-Lipophosphonoxins: A Novel Approach in Designing Membrane Targeting Antimicrobials.
AID529138	Antimicrobial activity against methicillin-resistant Staphylococcus aureus USA300 assessed as concentration required for minimum inhibition of oxacillin-resistant subpopulation growth by Etest	2008	Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8	Comparative study of the susceptibilities of major epidemic clones of methicillin-resistant Staphylococcus aureus to oxacillin and to the new broad-spectrum cephalosporin ceftobiprole.
AID721790	Antibacterial activity against vancomycin-sensitive Enterococcus faecalis ATCC 19433 assessed as growth inhibition after 24 hrs by CLSI broth microdilution method	2013	European journal of medicinal chemistry, Feb, Volume: 60	Antimicrobial activity of various 4- and 5-substituted 1-phenylnaphthalenes.
AID1567119	Antimicrobial activity against Staphylococcus aureus ATCC 29213 incubated for 20 hrs by microdilution method	2019	European journal of medicinal chemistry, Sep-15, Volume: 178	Design, synthesis and biological evaluation of antimicrobial diarylimine and -amine compounds targeting the interaction between the bacterial NusB and NusE proteins.
AID1079940	Granulomatous liver disease, proven histopathologically. Value is number of references indexed. [column 'GRAN' in source]
AID548326	Antibacterial activity against Staphylococcus aureus QRSA CCARM 3505 after 20 hrs by twofold serial dilution technique	2010	European journal of medicinal chemistry, Dec, Volume: 45, Issue:12	Synthesis of new chalcone derivatives containing a rhodanine-3-acetic acid moiety with potential anti-bacterial activity.
AID375939	Antibacterial activity against methicillin-resistant Staphylococcus aureus 78-13607A after 24 hrs by broth microdilution method	2006	Journal of natural products, Apr, Volume: 69, Issue:4	Antibacterial, partially acetylated oligorhamnosides from Cleistopholis patens.
AID1638998	Antibacterial activity against Bacillus subtilis ATCC 6051 after 24 hrs by resazurin dye based fluorescence assay	2019	Journal of natural products, 04-26, Volume: 82, Issue:4	Mindapyrroles A-C, Pyoluteorin Analogues from a Shipworm-Associated Bacterium.
AID759328	Antibacterial activity against Staphylococcus aureus RN4220 after 24 hrs by broth microdilution method	2013	Bioorganic & medicinal chemistry letters, Aug-01, Volume: 23, Issue:15	Synthesis and biological evaluation of rhodanine derivatives bearing a quinoline moiety as potent antimicrobial agents.
AID564825	Antimicrobial activity against methicillin-susceptible Staphylococcus aureus assessed as susceptible isolates after 24 hrs by broth microdilution method	2009	Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10	In vitro activities of panduratin A against clinical Staphylococcus strains.
AID520291	Antimicrobial activity against Staphylococcus aureus 2548	2008	Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5	Activities of daptomycin and comparative antimicrobials, singly and in combination, against extracellular and intracellular Staphylococcus aureus and its stable small-colony variant in human monocyte-derived macrophages and in broth.
AID548324	Antibacterial activity against Staphylococcus aureus MRSA CCARM 3167 after 20 hrs by twofold serial dilution technique	2010	European journal of medicinal chemistry, Dec, Volume: 45, Issue:12	Synthesis of new chalcone derivatives containing a rhodanine-3-acetic acid moiety with potential anti-bacterial activity.
AID528498	Antimicrobial activity against low level levofloxacin and methicillin-resistant Staphylococcus aureus JCSC 6767 expressing gyrA Glu84Lys and grlA Ser80Phe mutants by broth microdilution method	2008	Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8	Postantibiotic effects and bactericidal activities of levofloxacin and gatifloxacin at concentrations simulating those of topical ophthalmic administration against fluoroquinolone-resistant and fluoroquinolone-sensitive methicillin-resistant Staphylococcu
AID750311	Antibacterial activity against Staphylococcus aureus isolate D14 derived from bone assessed as growth inhibition after 18 hrs by broth microdilution method	2013	European journal of medicinal chemistry, Jun, Volume: 64	Synthesis and evaluation of antimicrobial activity of hydrazones derived from 3-oxido-1H-imidazole-4-carbohydrazides.
AID285916	Antimicrobial activity against methicillin-susceptible Staphylococcus aureus ATCC 29213	2007	Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4	Antimicrobial activities of daptomycin, vancomycin, and oxacillin in human monocytes and of daptomycin in combination with gentamicin and/or rifampin in human monocytes and in broth against Staphylococcus aureus.
AID531551	Antibacterial activity against Staphylococcus aureus obtained from complicated skin and skin structure infections by agar dilution method	2008	Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9	In vitro activity of ceftobiprole against pathogens from two phase 3 clinical trials of complicated skin and skin structure infections.
AID404952	Antibacterial activity against methicillin-susceptible coagulase-negative Staphylococcus sp. assessed as percent susceptible isolates by CLSI dilution method	2007	Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7	In vitro activities of CG400549, a novel FabI inhibitor, against recently isolated clinical staphylococcal strains in Korea.
AID396030	Antibacterial activity against drug-resistant AcrAB-TolC efflux pump deficient Enterobacter cloacae EcdeltaacrA isolate expressing pAP2 plasmid containing Enterobacter cloacae acrA gene by Etest	2007	Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9	Cloning, nucleotide sequencing, and analysis of the AcrAB-TolC efflux pump of Enterobacter cloacae and determination of its involvement in antibiotic resistance in a clinical isolate.
AID750299	Bactericidal activity against Staphylococcus aureus isolate D14 derived from bone after 18 hrs by broth microdilution method	2013	European journal of medicinal chemistry, Jun, Volume: 64	Synthesis and evaluation of antimicrobial activity of hydrazones derived from 3-oxido-1H-imidazole-4-carbohydrazides.
AID1559377	Antibacterial activity against Klebsiella pneumoniae 11978 expressing OXA-48 after 16 to 20 hrs by CLSI-based microbroth dilution method	2020	Journal of medicinal chemistry, 03-26, Volume: 63, Issue:6	Discovery of Taniborbactam (VNRX-5133): A Broad-Spectrum Serine- and Metallo-β-lactamase Inhibitor for Carbapenem-Resistant Bacterial Infections.
AID561078	Antibacterial activity against methicillin-resistant Staphylococcus epidermidis by CLSI M7-A7 broth microdilution method	2009	Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8	In vitro activity of TR-700, the active ingredient of the antibacterial prodrug TR-701, a novel oxazolidinone antibacterial agent.
AID1294672	Antimicrobial activity against methicillin-resistant Staphylococcus aureus isolate 18a after 24 hrs by agar plate dilution method	2016	European journal of medicinal chemistry, Jun-10, Volume: 115	Anti-methicillin resistant Staphylococcus aureus activity, synergism with oxacillin and molecular docking studies of metronidazole-triazole hybrids.
AID1870139	Antibacterial activity against wild type methicillin resistant Staphylococcus aureus 5017/C assessed as reduction in microbial growth incubated for 24 hrs by microdilution assay	2022	Journal of medicinal chemistry, 07-28, Volume: 65, Issue:14	LEGO-Lipophosphonoxins: A Novel Approach in Designing Membrane Targeting Antimicrobials.
AID402926	Antimicrobial activity against methicillin-resistant Staphylococcus aureus 2 after 24 hrs	2004	Journal of natural products, Jun, Volume: 67, Issue:6	New stilbene derivatives from Calligonum leucocladum.
AID556043	Antimicrobial activity against erythromycin-resistant, tetracycline-sensitive and rsbUVW-sigB operon deficient Staphylococcus aureus COL mutant by broth microdilution method	2009	Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5	Functional characterization of the sigmaB-dependent yabJ-spoVG operon in Staphylococcus aureus: role in methicillin and glycopeptide resistance.
AID521077	Antibacterial activity against group 5 PVL negative community-acquired methicillin-resistant Staphylococcus aureus ST 5 expressing SCCmec type II gene by agar dilution method	2008	Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3	Novel characteristics of community-acquired methicillin-resistant Staphylococcus aureus strains belonging to multilocus sequence type 59 in Taiwan.
AID531571	Antibacterial activity against Streptococcus constellatus obtained from complicated skin and skin structure infections by agar dilution method	2008	Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9	In vitro activity of ceftobiprole against pathogens from two phase 3 clinical trials of complicated skin and skin structure infections.
AID529118	Antimicrobial activity against methicillin-resistant Staphylococcus aureus USA300 by Etest	2008	Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8	Comparative study of the susceptibilities of major epidemic clones of methicillin-resistant Staphylococcus aureus to oxacillin and to the new broad-spectrum cephalosporin ceftobiprole.
AID565755	Antimicrobial activity against Staphylococcus haemolyticus clinical isolates by broth microdilution method	2009	Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11	Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates.
AID373189	Induction of VraSR-dependent tcaA gene expression in Staphylococcus aureus KVR expressing N315 delta-vraSr mutant at 10 ug/mL after 30 mins by Northern blot analysis	2007	Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11	Functional characterization of TcaA: minimal requirement for teicoplanin susceptibility and role in Caenorhabditis elegans virulence.
AID362546	Antibacterial activity against epidemic methicillin-resistant Staphylococcus aureus 16 after 18 hrs	2008	Journal of natural products, Aug, Volume: 71, Issue:8	Antibacterial cannabinoids from Cannabis sativa: a structure-activity study.
AID1559378	Antibacterial activity against Enterobacter cloacae 144200 expressing p99 AmpC after 16 to 20 hrs by CLSI-based microbroth dilution method	2020	Journal of medicinal chemistry, 03-26, Volume: 63, Issue:6	Discovery of Taniborbactam (VNRX-5133): A Broad-Spectrum Serine- and Metallo-β-lactamase Inhibitor for Carbapenem-Resistant Bacterial Infections.
AID429446	Antimicrobial activity against vancomycin-intermediate Staphylococcus aureus isolate 10	2009	Bioorganic & medicinal chemistry letters, Aug-15, Volume: 19, Issue:16	Isoplatensimycin: Synthesis and biological evaluation.
AID544613	Antibacterial activity against Staphylococcus aureus isolate 1326 infected in Wistar rat thigh infection model assessed as bacterial load per gram of thigh at 200 mg/kg, sc administered 2 hrs postinfection and every 6 hrs thereafter for 1 day measured aft	2008	Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11	In vitro and in vivo evaluations of oxacillin efficiency against mecA-positive oxacillin-susceptible Staphylococcus aureus.
AID405589	Effect on vraSR gene expression in in oxacillin-dependent methicillin-resistant Staphylococcus aureus 2884D isolate in presence of blood agar by RT-PCR	2007	Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7	Identification and phenotypic characterization of a beta-lactam-dependent, methicillin-resistant Staphylococcus aureus strain.
AID765061	Antimicrobial activity against vancomycin-sensitive Enterococcus faecalis ATCC 19433 by broth microdilution method	2013	Bioorganic & medicinal chemistry letters, Sep-01, Volume: 23, Issue:17	Antibacterial activity of quinoxalines, quinazolines, and 1,5-naphthyridines.
AID761554	Antibacterial activity against Escherichia coli ATCC 25922 by M07-A9 CLSI method	2013	Bioorganic & medicinal chemistry letters, Aug-01, Volume: 23, Issue:15	Synthesis and antimicrobial activity of imidazole and pyridine appended cholestane-based conjugates.
AID533936	Antimicrobial activity against linezolid-resistant Staphylococcus aureus 131-6952X harboring plasmid borne cfr gene by broth microdilution method	2008	Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12	In vitro activity of TR-700, the antibacterial moiety of the prodrug TR-701, against linezolid-resistant strains.
AID1601845	Antibacterial activity against Enterococcus faecalis CMCC 29212 measured after 24 hrs by ELISA	2019	European journal of medicinal chemistry, Mar-15, Volume: 166	Synthesis, antimicrobial and cytotoxic activities, and molecular docking studies of N-arylsulfonylindoles containing an aminoguanidine, a semicarbazide, and a thiosemicarbazide moiety.
AID405591	Increase in ccpA gene expression in oxacillin-dependent methicillin-resistant Staphylococcus aureus 2884D isolate at 0.5 ug/ml by microarray-based transcriptional profiling relative to control	2007	Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7	Identification and phenotypic characterization of a beta-lactam-dependent, methicillin-resistant Staphylococcus aureus strain.
AID1079934	Highest frequency of acute liver toxicity observed during clinical trials, expressed as a percentage. [column '% AIGUE' in source]
AID405601	Increase in MRSA 252 glycosyltransferase gene expression in oxacillin-dependent methicillin-resistant Staphylococcus aureus 2884D isolate at 0.5 ug/ml by microarray-based transcriptional profiling relative to control	2007	Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7	Identification and phenotypic characterization of a beta-lactam-dependent, methicillin-resistant Staphylococcus aureus strain.
AID529121	Antimicrobial activity against methicillin-resistant Staphylococcus aureus E2125 assessed as concentration required for bacterial subpopulation growth	2008	Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8	Comparative study of the susceptibilities of major epidemic clones of methicillin-resistant Staphylococcus aureus to oxacillin and to the new broad-spectrum cephalosporin ceftobiprole.
AID750298	Bactericidal activity against Staphylococcus aureus isolate D15 derived from bone after 18 hrs by broth microdilution method	2013	European journal of medicinal chemistry, Jun, Volume: 64	Synthesis and evaluation of antimicrobial activity of hydrazones derived from 3-oxido-1H-imidazole-4-carbohydrazides.
AID520868	Antibacterial activity against methicillin-resistant mecA-positive Staphylococcus saprophyticus isolate TSU28 isolated from genitourinary tracts of acute cystitis patient after 24 hrs at 35 degC by agar dilution method	2008	Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6	Methicillin-resistant Staphylococcus saprophyticus isolates carrying staphylococcal cassette chromosome mec have emerged in urogenital tract infections.
AID1055325	Antibacterial activity against New Delhi metallo-beta-lactamase 1 producing Klebsiella pneumoniae ATCC BAA-2146 assessed as growth inhibition after 18 hrs by agar dilution method	2013	Journal of natural products, Nov-22, Volume: 76, Issue:11	Identification of elaiophylin derivatives from the marine-derived actinomycete Streptomyces sp. 7-145 using PCR-based screening.
AID520730	Activity of Escherichia coli DH10B beta-lactamase assessed per mg of protein at 100 uM	2008	Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5	Carbapenem-resistant Acinetobacter baumannii isolates from Tunisia producing the OXA-58-like carbapenem-hydrolyzing oxacillinase OXA-97.
AID750340	Antibacterial activity against Enterococcus faecalis ATCC 29212 assessed as growth inhibition after 18 hrs by broth microdilution method	2013	European journal of medicinal chemistry, Jun, Volume: 64	Synthesis and evaluation of antimicrobial activity of hydrazones derived from 3-oxido-1H-imidazole-4-carbohydrazides.
AID1559375	Antibacterial activity against Klebsiella pneumoniae UMM expressing SHV5/KPC-2/TEM-1 after 16 to 20 hrs by CLSI-based microbroth dilution method	2020	Journal of medicinal chemistry, 03-26, Volume: 63, Issue:6	Discovery of Taniborbactam (VNRX-5133): A Broad-Spectrum Serine- and Metallo-β-lactamase Inhibitor for Carbapenem-Resistant Bacterial Infections.
AID362545	Antibacterial activity against epidemic methicillin-resistant Staphylococcus aureus 15 after 18 hrs	2008	Journal of natural products, Aug, Volume: 71, Issue:8	Antibacterial cannabinoids from Cannabis sativa: a structure-activity study.
AID560502	Antimicrobial activity against SCCmec type III vancomycin-intermediate Staphylococcus aureus isolate gz06051 by agar dilution method	2009	Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9	Prevalence and characterization of heterogeneous vancomycin-intermediate Staphylococcus aureus isolates from 14 cities in China.
AID1759644	Antimicrobial activity against vancomycin-resistant Enterococcus faecium clinical isolate 1100440 by CLSI-based broth microdilution assay	2021	European journal of medicinal chemistry, Jul-05, Volume: 219	4-4-(Anilinomethyl)-3-[4-(trifluoromethyl)phenyl]-1H-pyrazol-1-ylbenzoic acid derivatives as potent anti-gram-positive bacterial agents.
AID1055330	Antibacterial activity against vancomycin-sensitive Enterococcus faecium 09-10 assessed as growth inhibition after 18 hrs by agar dilution method	2013	Journal of natural products, Nov-22, Volume: 76, Issue:11	Identification of elaiophylin derivatives from the marine-derived actinomycete Streptomyces sp. 7-145 using PCR-based screening.
AID564824	Antimicrobial activity against methicillin-resistant Staphylococcus aureus assessed as resistant isolates after 24 hrs by broth microdilution method	2009	Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10	In vitro activities of panduratin A against clinical Staphylococcus strains.
AID570770	Antimicrobial activity against wild type hospital-acquired methicillin-resistant vancomycin-intermediate Staphylococcus aureus Mu50 serotype USA100 by microdilution method	2008	Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11	Staphylococcus aureus PBP4 is essential for beta-lactam resistance in community-acquired methicillin-resistant strains.
AID1763155	Antibacterial activity against Enterococcus faecalis ATCC 29212 assessed as reduction in bacterial growth incubated for 24 hrs by CLSI based serial dilution method	2021	Bioorganic & medicinal chemistry, 05-15, Volume: 38	Antibacterial and synergistic activity of 6β-hydroxy-3-oxolup-20(29)-en-28-oic acid (6β-hydroxy betunolic acid) isolated from Schumacheria castaneifolia vahl.
AID1827251	Upregulation of blaZ gene expression in methicillin-resistant Staphylococcus aureus ATCC 43300 by RT-PCR method	2022	ACS medicinal chemistry letters, Mar-10, Volume: 13, Issue:3	Identification and Evaluation of Brominated Carbazoles as a Novel Antibiotic Adjuvant Scaffold in MRSA.
AID533934	Antimicrobial activity against linezolid-resistant Staphylococcus aureus CM/05 3067 harboring chromosomal cfr gene by broth microdilution method	2008	Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12	In vitro activity of TR-700, the antibacterial moiety of the prodrug TR-701, against linezolid-resistant strains.
AID523272	Antimicrobial activity against Escherichia coli HN1157/pHSG576oxa7 assessed as minimal drug concentration	2010	Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5	Kinetic parameters of efflux of penicillins by the multidrug efflux transporter AcrAB-TolC of Escherichia coli.
AID1737460	Antibacterial activity against methicillin resistant Staphylococcus aureus S-37 after 16 to 18 hrs by CLSI-based microbroth dilution method	2020	European journal of medicinal chemistry, Jun-01, Volume: 195	Synthesis of novel monocarbonyl curcuminoids, evaluation of their efficacy against MRSA, including ex vivo infection model and their mechanistic studies.
AID285928	Antimicrobial activity against methicillin-resistant Staphylococcus aureus ATCC 43300 in human monocyte-derived macrophages at 5 ug/ml assessed as bacterial viability after 4 hrs	2007	Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4	Antimicrobial activities of daptomycin, vancomycin, and oxacillin in human monocytes and of daptomycin in combination with gentamicin and/or rifampin in human monocytes and in broth against Staphylococcus aureus.
AID521069	Antibacterial activity against group 1-v4 PVL+ community-acquired methicillin-resistant Staphylococcus aureus ST 59 expressing SCCmec type VT gene by agar dilution method	2008	Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3	Novel characteristics of community-acquired methicillin-resistant Staphylococcus aureus strains belonging to multilocus sequence type 59 in Taiwan.
AID1517061	Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC 19494 assessed as reduction in bacterial growth incubated for 24 hrs by serial dilution method	2019	European journal of medicinal chemistry, Dec-01, Volume: 183	Two optimized antimicrobial peptides with therapeutic potential for clinical antibiotic-resistant Staphylococcus aureus.
AID560522	Antimicrobial activity against SCCmec type III vancomycin-intermediate Staphylococcus aureus isolate gz07030 by agar dilution method	2009	Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9	Prevalence and characterization of heterogeneous vancomycin-intermediate Staphylococcus aureus isolates from 14 cities in China.
AID718416	Antibacterial activity against log-phase methicillin-sensitive Staphylococcus aureus 8325-4 assessed as growth inhibition after 24 hrs by broth microdilution method	2012	Bioorganic & medicinal chemistry, Dec-15, Volume: 20, Issue:24	3-Phenyl substituted 6,7-dimethoxyisoquinoline derivatives as FtsZ-targeting antibacterial agents.
AID432980	Antimicrobial activity against SCCmec type 1 methicillin-resistant Staphylococcus aureus COL 319-T1 expressing symporter gene smr1 at 42 degC incubated for 24 hrs by E-test	2008	Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2	Role of a sodium-dependent symporter homologue in the thermosensitivity of beta-lactam antibiotic resistance and cell wall composition in Staphylococcus aureus.
AID548127	Antibacterial activity against Staphylococcus aureus KCTC 503 after 20 hrs by twofold serial dilution technique	2010	European journal of medicinal chemistry, Dec, Volume: 45, Issue:12	Synthesis of new chalcone derivatives containing a rhodanine-3-acetic acid moiety with potential anti-bacterial activity.
AID405475	Antibacterial activity against oxacillin-dependent methicillin-resistant Staphylococcus aureus 2884D isolate assessed as decrease in log bacterial count at >= 256 ug/ml	2007	Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7	Identification and phenotypic characterization of a beta-lactam-dependent, methicillin-resistant Staphylococcus aureus strain.
AID667557	Antibacterial activity against Staphylococcus aureus KCTC 503 after 24 hrs by two-fold serial dilution method	2012	European journal of medicinal chemistry, Aug, Volume: 54	Synthesis and bioactivity evaluation of rhodanine derivatives as potential anti-bacterial agents.
AID529122	Antimicrobial activity against methicillin-resistant Staphylococcus aureus HPV107 assessed as concentration required for bacterial subpopulation growth	2008	Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8	Comparative study of the susceptibilities of major epidemic clones of methicillin-resistant Staphylococcus aureus to oxacillin and to the new broad-spectrum cephalosporin ceftobiprole.
AID1055343	Antibacterial activity against methicillin-sensitive Staphylococcus aureus 09-6 assessed as growth inhibition after 18 hrs by agar dilution method	2013	Journal of natural products, Nov-22, Volume: 76, Issue:11	Identification of elaiophylin derivatives from the marine-derived actinomycete Streptomyces sp. 7-145 using PCR-based screening.
AID404934	Antibacterial activity against methicillin-resistant Staphylococcus aureus by CLSI dilution method	2007	Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7	In vitro activities of CG400549, a novel FabI inhibitor, against recently isolated clinical staphylococcal strains in Korea.
AID559536	Antibacterial activity against Moraxella catarrhalis assessed as percent susceptible isolates by CLSI M7-A7 method	2009	Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8	Besifloxacin, a novel fluoroquinolone, has broad-spectrum in vitro activity against aerobic and anaerobic bacteria.
AID1474166	Liver toxicity in human assessed as induction of drug-induced liver injury by measuring severity class index	2016	Drug discovery today, Apr, Volume: 21, Issue:4	DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
AID1567126	Antimicrobial activity against Staphylococcus saprophyticus ATCC 15305 incubated for 20 hrs by microdilution method	2019	European journal of medicinal chemistry, Sep-15, Volume: 178	Design, synthesis and biological evaluation of antimicrobial diarylimine and -amine compounds targeting the interaction between the bacterial NusB and NusE proteins.
AID559770	Antimicrobial activity against SCCmec type II vancomycin-intermediate Staphylococcus aureus isolate 4sy32 by agar dilution method	2009	Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9	Prevalence and characterization of heterogeneous vancomycin-intermediate Staphylococcus aureus isolates from 14 cities in China.
AID574554	Decrease in PSMbeta1 levels in Staphylococcus aureus USA300 at subinhibitory concentration after 24 hrs by RP-HPLC/ESI-MS	2010	Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11	Subinhibitory concentrations of protein synthesis-inhibiting antibiotics promote increased expression of the agr virulence regulator and production of phenol-soluble modulin cytolysins in community-associated methicillin-resistant Staphylococcus aureus.
AID761550	Antibacterial activity against Pseudomonas aeruginosa 6065Y by M07-A9 CLSI method	2013	Bioorganic & medicinal chemistry letters, Aug-01, Volume: 23, Issue:15	Synthesis and antimicrobial activity of imidazole and pyridine appended cholestane-based conjugates.
AID431118	Antibacterial activity against vancomycin-intermediate Staphylococcus aureus Mu50 after 24 hrs by agar dilution method	2008	Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1	Mutated response regulator graR is responsible for phenotypic conversion of Staphylococcus aureus from heterogeneous vancomycin-intermediate resistance to vancomycin-intermediate resistance.
AID432976	Antimicrobial activity against SCCmec type 3 methicillin-resistant Staphylococcus aureus COL 301-T6 expressing symporter gene smr1 at 42 degC incubated for 24 hrs by E-test	2008	Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2	Role of a sodium-dependent symporter homologue in the thermosensitivity of beta-lactam antibiotic resistance and cell wall composition in Staphylococcus aureus.
AID1651743	Antibacterial activity against Enterococcus durans MB113 after 24 hrs by microdilution assay	2020	Journal of natural products, 04-24, Volume: 83, Issue:4	Antibacterial and ATP Synthesis Modulating Compounds from
AID685404	Antibacterial activity against Escherichia coli CCARM 1356 after 24 hrs by broth microdilution method	2012	European journal of medicinal chemistry, Oct, Volume: 56	Synthesis and antimicrobial evaluation of L-phenylalanine-derived C5-substituted rhodanine and chalcone derivatives containing thiobarbituric acid or 2-thioxo-4-thiazolidinone.
AID285349	Antibacterial activity against community acquired methicillin-resistant Staphylococcus aureus HT20030203 in CCY media	2007	Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4	Effect of antibiotics on Staphylococcus aureus producing Panton-Valentine leukocidin.
AID523274	Activity at Escherichia coli isolate 7181 beta-lactamase OXA-7 measured per mg of protein	2010	Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5	Kinetic parameters of efflux of penicillins by the multidrug efflux transporter AcrAB-TolC of Escherichia coli.
AID558759	Antibacterial activity against hetero-vancomycin-intermediate Staphylococcus aureus Mu3 by Etest method	2009	Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8	Selection of heterogeneous vancomycin-intermediate Staphylococcus aureus by imipenem.
AID761553	Antibacterial activity against Salmonella typhimurium ATCC 13311 by M07-A9 CLSI method	2013	Bioorganic & medicinal chemistry letters, Aug-01, Volume: 23, Issue:15	Synthesis and antimicrobial activity of imidazole and pyridine appended cholestane-based conjugates.
AID565011	Bactericidal activity against methicillin-susceptible coagulase-negative Staphylococcus haemolyticus after 24 hrs by plate counting method	2009	Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10	In vitro activities of panduratin A against clinical Staphylococcus strains.
AID405583	Induction of blaR1 gene expression in methicillin-resistant Staphylococcus aureus 2884 isolate by RT-PCR	2007	Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7	Identification and phenotypic characterization of a beta-lactam-dependent, methicillin-resistant Staphylococcus aureus strain.
AID285921	Antimicrobial activity against methicillin-resistant Staphylococcus aureus ATCC 43300 in human monocyte-derived macrophages at 0.5 ug/ml assessed as bacterial viability after 2 hrs	2007	Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4	Antimicrobial activities of daptomycin, vancomycin, and oxacillin in human monocytes and of daptomycin in combination with gentamicin and/or rifampin in human monocytes and in broth against Staphylococcus aureus.
AID574291	Antimicrobial activity against community-acquired pbp4-deficient Staphylococcus aureus MW2 serotype USA400 by microdilution method	2008	Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11	Staphylococcus aureus PBP4 is essential for beta-lactam resistance in community-acquired methicillin-resistant strains.
AID685401	Antibacterial activity against Staphylococcus aureus KCTC 209 after 24 hrs by broth microdilution method	2012	European journal of medicinal chemistry, Oct, Volume: 56	Synthesis and antimicrobial evaluation of L-phenylalanine-derived C5-substituted rhodanine and chalcone derivatives containing thiobarbituric acid or 2-thioxo-4-thiazolidinone.
AID405607	Decrease in SA2390 COL vraR gene expression in oxacillin-dependent methicillin-resistant Staphylococcus aureus 2884D isolate at 0.5 ug/ml by microarray-based transcriptional profiling relative to control	2007	Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7	Identification and phenotypic characterization of a beta-lactam-dependent, methicillin-resistant Staphylococcus aureus strain.
AID548325	Antibacterial activity against Staphylococcus aureus MRSA CCARM 3506 after 20 hrs by twofold serial dilution technique	2010	European journal of medicinal chemistry, Dec, Volume: 45, Issue:12	Synthesis of new chalcone derivatives containing a rhodanine-3-acetic acid moiety with potential anti-bacterial activity.
AID1567136	Antimicrobial activity against Staphylococcus aureus ST22 11B086169 incubated for 20 hrs by microdilution method	2019	European journal of medicinal chemistry, Sep-15, Volume: 178	Design, synthesis and biological evaluation of antimicrobial diarylimine and -amine compounds targeting the interaction between the bacterial NusB and NusE proteins.
AID558780	Antibacterial activity against acrEF-deficient Salmonella enterica NKS176 by CLSI method	2009	Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8	H-NS modulates multidrug resistance of Salmonella enterica serovar Typhimurium by repressing multidrug efflux genes acrEF.
AID1225388	Antibacterial activity against Escherichia coli transformed with plasmid carrying MG1655 deltaBC/pABM by p-iodonitrotetrazolium chloride colorimetric assay	2015	Journal of natural products, Mar-27, Volume: 78, Issue:3	Enhancement of antibiotic activity against multidrug-resistant bacteria by the efflux pump inhibitor 3,4-dibromopyrrole-2,5-dione isolated from a Pseudoalteromonas sp.
AID761557	Antibacterial activity against Bacillus subtilis ATCC 6633 by M07-A9 CLSI method	2013	Bioorganic & medicinal chemistry letters, Aug-01, Volume: 23, Issue:15	Synthesis and antimicrobial activity of imidazole and pyridine appended cholestane-based conjugates.
AID562597	Antimicrobial activity against oxacillin-resistant Staphylococcus haemolyticus clinical isolates assessed as resistant isolates by broth microdilution method	2009	Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11	Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates.
AID565002	Antimicrobial activity against methicillin-susceptible coagulase-negative Staphylococcus hominis assessed as resistant isolates after 24 hrs by broth microdilution method	2009	Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10	In vitro activities of panduratin A against clinical Staphylococcus strains.
AID1330194	Antibacterial activity against methicillin-resistant Staphylococcus aureus 3167 measured after 24 hrs by two-fold serial dilution method	2016	Bioorganic & medicinal chemistry letters, 12-15, Volume: 26, Issue:24	Synthesis and biological evaluation of chalcone derivatives containing aminoguanidine or acylhydrazone moieties.
AID432810	Antimicrobial activity against SCCmec type 1 methicillin-resistant Staphylococcus aureus COL D19455 expressing symporter gene smr1 at 42 degC incubated for 24 hrs by E-test	2008	Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2	Role of a sodium-dependent symporter homologue in the thermosensitivity of beta-lactam antibiotic resistance and cell wall composition in Staphylococcus aureus.
AID761556	Antibacterial activity against Bacillus cereus ATCC 27348 by M07-A9 CLSI method	2013	Bioorganic & medicinal chemistry letters, Aug-01, Volume: 23, Issue:15	Synthesis and antimicrobial activity of imidazole and pyridine appended cholestane-based conjugates.
AID564831	Antimicrobial activity against methicillin-resistant coagulase-negative Staphylococcus sciuri assessed as resistant isolates after 24 hrs by broth microdilution method	2009	Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10	In vitro activities of panduratin A against clinical Staphylococcus strains.
AID1759647	Antimicrobial activity against vancomycin-resistant Enterococcus faecium clinical isolate 1088925 by CLSI-based broth microdilution assay	2021	European journal of medicinal chemistry, Jul-05, Volume: 219	4-4-(Anilinomethyl)-3-[4-(trifluoromethyl)phenyl]-1H-pyrazol-1-ylbenzoic acid derivatives as potent anti-gram-positive bacterial agents.
AID285362	Increase in Panton-Valentine leukocidin level in community acquired methicillin-resistant Staphylococcus aureus HT20041010 in CYY medium	2007	Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4	Effect of antibiotics on Staphylococcus aureus producing Panton-Valentine leukocidin.
AID562391	Antimicrobial activity against oxacillin-susceptible Staphylococcus haemolyticus clinical isolates assessed as percent susceptible isolates by broth microdilution method	2009	Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11	Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates.
AID529124	Antimicrobial activity against methicillin-resistant Staphylococcus aureus HDE288 assessed as concentration required for bacterial subpopulation growth	2008	Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8	Comparative study of the susceptibilities of major epidemic clones of methicillin-resistant Staphylococcus aureus to oxacillin and to the new broad-spectrum cephalosporin ceftobiprole.
AID501193	Antimicrobial activity against vancomycin-resistant Enterococcus faecium 379 at 1 unit after 18 hrs by agar diffusion method	2009	Journal of natural products, Oct, Volume: 72, Issue:10	Norselic acids A-E, highly oxidized anti-infective steroids that deter mesograzer predation, from the Antarctic sponge Crella sp.
AID717272	Antimicrobial activity against vancomycin-sensitive Enterococcus faecalis ATCC 19433 by CLSI protocol based broth microdilution method	2012	Bioorganic & medicinal chemistry letters, Dec-01, Volume: 22, Issue:23	Antibacterial activity of substituted 5-methylbenzo[c]phenanthridinium derivatives.
AID1197134	Plasma protein binding in human by equilibrium dialysis assay	2015	Journal of medicinal chemistry, Feb-12, Volume: 58, Issue:3	Structure-activity relationship for the oxadiazole class of antibiotics.
AID531578	Antibacterial activity against Lactococcus lactis obtained from complicated skin and skin structure infections by agar dilution method	2008	Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9	In vitro activity of ceftobiprole against pathogens from two phase 3 clinical trials of complicated skin and skin structure infections.
AID1853617	Antibacterial activity against Staphylococcus aureus clinical isolate 1088610 assessed as inhibition of bacterial growth by CLSI protocol based broth microdilution method	2021	RSC medicinal chemistry, Oct-20, Volume: 12, Issue:10	Design, synthesis, and antibacterial activity of
AID524382	Antibacterial activity against Escherichia coli NKE160 harboring deletion mutation in acrB protein and vector expressing tolC gene	2010	Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5	Effect of NlpE overproduction on multidrug resistance in Escherichia coli.
AID750345	Antibacterial activity against Escherichia coli NCTC 8192 assessed as growth inhibition after 18 hrs by broth microdilution method	2013	European journal of medicinal chemistry, Jun, Volume: 64	Synthesis and evaluation of antimicrobial activity of hydrazones derived from 3-oxido-1H-imidazole-4-carbohydrazides.
AID429361	Antimicrobial activity against methicillin-resistant Staphylococcus aureus isolate 5	2009	Bioorganic & medicinal chemistry letters, Aug-15, Volume: 19, Issue:16	Isoplatensimycin: Synthesis and biological evaluation.
AID558758	Antibacterial activity against homo-Methicillin-resistant and tetracycline-resistant and rifampicin-resistant Staphylococcus aureus deltaIP-rifR::vraSH14 by Etest method	2009	Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8	Selection of heterogeneous vancomycin-intermediate Staphylococcus aureus by imipenem.
AID544598	Effect on growth of Staphylococcus aureus isolate 1326 assessed as highest compound concentration at which cell growth occurred measured after 48 hrs	2008	Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11	In vitro and in vivo evaluations of oxacillin efficiency against mecA-positive oxacillin-susceptible Staphylococcus aureus.
AID548130	Antibacterial activity against Streptococcus mutans KCTC 3289 after 20 hrs by twofold serial dilution technique	2010	European journal of medicinal chemistry, Dec, Volume: 45, Issue:12	Synthesis of new chalcone derivatives containing a rhodanine-3-acetic acid moiety with potential anti-bacterial activity.
AID519456	Antimicrobial activity against homotypic oxacillin resistant and vancomycin resistant Staphylococcus aureus isolate 5827V32 by broth microdilution method	2008	Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4	Spontaneous deletion of the methicillin resistance determinant, mecA, partially compensates for the fitness cost associated with high-level vancomycin resistance in Staphylococcus aureus.
AID1888847	Antibacterial activity against Staphylococcus aureus 1199 measured after 24 hrs by Muller Hinton broth based MTT assay	2022	Bioorganic & medicinal chemistry, 01-15, Volume: 54	Potentiating the intracellular killing of Staphylococcus aureus by dihydroquinazoline analogues as NorA efflux pump inhibitor.
AID694208	Antibacterial activity against vancomycin-resistant Enterococcus faecalis ATCC 51575 by CLSI broth microdilution method	2012	Bioorganic & medicinal chemistry letters, Nov-15, Volume: 22, Issue:22	Antibacterial activity of substituted dibenzo[a,g]quinolizin-7-ium derivatives.
AID501195	Antimicrobial activity against Candida albicans 54 at 1 unit after 18 hrs by agar diffusion method	2009	Journal of natural products, Oct, Volume: 72, Issue:10	Norselic acids A-E, highly oxidized anti-infective steroids that deter mesograzer predation, from the Antarctic sponge Crella sp.
AID544592	Antibacterial activity against Staphylococcus aureus isolate 1552 by agar dilution method	2008	Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11	In vitro and in vivo evaluations of oxacillin efficiency against mecA-positive oxacillin-susceptible Staphylococcus aureus.
AID750343	Antibacterial activity against Staphylococcus aureus ATCC 29213 assessed as growth inhibition after 18 hrs by broth microdilution method	2013	European journal of medicinal chemistry, Jun, Volume: 64	Synthesis and evaluation of antimicrobial activity of hydrazones derived from 3-oxido-1H-imidazole-4-carbohydrazides.
AID520883	Activity of Achromobacter xylosoxidans CIP69598 beta-lactamase OXA-114a expressed in Escherichia coli TOP10 assessed as compound hydrolysis	2008	Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6	Characterization of a naturally occurring class D beta-lactamase from Achromobacter xylosoxidans.
AID405473	Increase in blaZ gene expression in methicillin-resistant Staphylococcus aureus 2884 isolate at 0.5 ug/ml by RT-PCR	2007	Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7	Identification and phenotypic characterization of a beta-lactam-dependent, methicillin-resistant Staphylococcus aureus strain.
AID1230065	Antibacterial activity against methicillin-resistant Staphylococcus aureus GRE2372 assessed as inhibition of bacterial growth	2015	Bioorganic & medicinal chemistry, Jul-01, Volume: 23, Issue:13	Synthesis and antimicrobial activity of chloramphenicol-polyamine conjugates.
AID405644	Induction of blaR1 gene expression in oxacillin-dependent methicillin-resistant Staphylococcus aureus 2884D isolate by RT-PCR	2007	Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7	Identification and phenotypic characterization of a beta-lactam-dependent, methicillin-resistant Staphylococcus aureus strain.
AID545949	Antimicrobial activity against methicillin-resistant Staphylococcus aureus 16645 by broth dilution method	2010	Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8	Identification of a novel transposon (Tn6072) and a truncated staphylococcal cassette chromosome mec element in methicillin-resistant Staphylococcus aureus ST239.
AID625279	Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for bilirubinemia	2011	PLoS computational biology, Dec, Volume: 7, Issue:12	Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
AID529140	Antimicrobial activity against methicillin-resistant Staphylococcus aureus HU25 assessed as concentration required for minimum inhibition of oxacillin-resistant subpopulation growth by Etest	2008	Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8	Comparative study of the susceptibilities of major epidemic clones of methicillin-resistant Staphylococcus aureus to oxacillin and to the new broad-spectrum cephalosporin ceftobiprole.
AID750338	Antibacterial activity against Pseudomonas aeruginosa NCTC 6249 assessed as growth inhibition after 18 hrs by broth microdilution method	2013	European journal of medicinal chemistry, Jun, Volume: 64	Synthesis and evaluation of antimicrobial activity of hydrazones derived from 3-oxido-1H-imidazole-4-carbohydrazides.
AID520871	Antibacterial activity against methicillin-resistant mecA-positive Staphylococcus saprophyticus isolate TSU57 isolated from genitourinary tracts of acute cystitis patient after 24 hrs at 35 degC by agar dilution method	2008	Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6	Methicillin-resistant Staphylococcus saprophyticus isolates carrying staphylococcal cassette chromosome mec have emerged in urogenital tract infections.
AID429360	Antimicrobial activity against methicillin-susceptible Staphylococcus aureus isolate 4	2009	Bioorganic & medicinal chemistry letters, Aug-15, Volume: 19, Issue:16	Isoplatensimycin: Synthesis and biological evaluation.
AID1294675	Antimicrobial activity against methicillin-resistant Staphylococcus aureus isolate 21a after 24 hrs by agar plate dilution method	2016	European journal of medicinal chemistry, Jun-10, Volume: 115	Anti-methicillin resistant Staphylococcus aureus activity, synergism with oxacillin and molecular docking studies of metronidazole-triazole hybrids.
AID542624	Antimicrobial activity against Streptococcus pneumoniae R6 harboring PBP2x T338G mutant gene, disruption at PBP1a and aad9 disruption in CiaR gene after 48 hrs by agar dilution method	2009	Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3	An important site in PBP2x of penicillin-resistant clinical isolates of Streptococcus pneumoniae: mutational analysis of Thr338.
AID432968	Antimicrobial activity against SCCmec type 1 methicillin-resistant Staphylococcus aureus COL E3005-T4 expressing symporter gene smr1 at 42 degC incubated for 24 hrs by E-test	2008	Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2	Role of a sodium-dependent symporter homologue in the thermosensitivity of beta-lactam antibiotic resistance and cell wall composition in Staphylococcus aureus.
AID1294680	Antimicrobial activity against methicillin-resistant Staphylococcus aureus isolate 26a after 24 hrs by agar plate dilution method	2016	European journal of medicinal chemistry, Jun-10, Volume: 115	Anti-methicillin resistant Staphylococcus aureus activity, synergism with oxacillin and molecular docking studies of metronidazole-triazole hybrids.
AID1503228	Antibacterial activity against methicillin-sensitive Staphylococcus aureus 209P after 24 hrs by liquid dilution method	2017	Journal of natural products, 10-27, Volume: 80, Issue:10	Structures and Antibacterial Properties of Isorugosins H-J, Oligomeric Ellagitannins from Liquidambar formosana with Characteristic Bridging Groups between Sugar Moieties.
AID245085	Minimum inhibitory concentration against methicillin resistant Staphylococcus aureus strain EMRSA 16	2005	Bioorganic & medicinal chemistry letters, May-16, Volume: 15, Issue:10	Synthesis and antibacterial activity of hydrolytically stable (-)-epicatechin gallate analogues for the modulation of beta-lactam resistance in Staphylococcus aureus.
AID509057	Antibacterial activity against beta-lactamase positive SCCmec type 3 methicillin-resistant Staphylococcus aureus isolate 12597 by broth microdilution method	2010	Antimicrobial agents and chemotherapy, Feb, Volume: 54, Issue:2	Effects of ceftobiprole and oxacillin on mecA expression in methicillin-resistant Staphylococcus aureus clinical isolates.
AID1294668	Antimicrobial activity against methicillin-resistant Staphylococcus aureus isolate 14a after 24 hrs by agar plate dilution method	2016	European journal of medicinal chemistry, Jun-10, Volume: 115	Anti-methicillin resistant Staphylococcus aureus activity, synergism with oxacillin and molecular docking studies of metronidazole-triazole hybrids.
AID285340	Antibacterial activity against Staphylococcus aureus LUG855 in Mueller-Hinton medium	2007	Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4	Effect of antibiotics on Staphylococcus aureus producing Panton-Valentine leukocidin.
AID556048	Antimicrobial activity against tetracycline-, glycopepeptide-intermediate-resistant and yabJ-spoVG operon deficient Staphylococcus aureus NCTC 8325 by broth microdilution method	2009	Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5	Functional characterization of the sigmaB-dependent yabJ-spoVG operon in Staphylococcus aureus: role in methicillin and glycopeptide resistance.
AID278669	Antibacterial activity against vancomycin-resistant Staphylococcus aureus isolate 2514	2007	Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1	High-level vancomycin-resistant Staphylococcus aureus isolates associated with a polymicrobial biofilm.
AID520290	Antimicrobial activity against Staphylococcus aureus 2547 small colony variants	2008	Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5	Activities of daptomycin and comparative antimicrobials, singly and in combination, against extracellular and intracellular Staphylococcus aureus and its stable small-colony variant in human monocyte-derived macrophages and in broth.
AID325475	Antibacterial activity against Staphylococcus aureus Mu50 assessed as inhibition of bacterial population at 128 ug/ml after 48 hrs	2007	Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6	Polyamine effects on antibiotic susceptibility in bacteria.
AID1225387	Antibacterial activity against Escherichia coli AG102 overexpressing AcrAB-TolC by p-iodonitrotetrazolium chloride colorimetric assay	2015	Journal of natural products, Mar-27, Volume: 78, Issue:3	Enhancement of antibiotic activity against multidrug-resistant bacteria by the efflux pump inhibitor 3,4-dibromopyrrole-2,5-dione isolated from a Pseudoalteromonas sp.
AID523266	Activity at Escherichia coli isolate 7181 beta-lactamase OXA-7	2010	Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5	Kinetic parameters of efflux of penicillins by the multidrug efflux transporter AcrAB-TolC of Escherichia coli.
AID431104	Antibacterial activity against mutated graSR gene knockout vancomycin-susceptible Staphylococcus aureus N315 after 24 hrs by agar dilution method	2008	Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1	Mutated response regulator graR is responsible for phenotypic conversion of Staphylococcus aureus from heterogeneous vancomycin-intermediate resistance to vancomycin-intermediate resistance.
AID509631	Antimicrobial activity against Staphylococcus aureus RN4220 transformant carrying plasmid pKKS25 and expressing erm(T), dfrK and tet(L) genes by broth microdilution method	2010	Antimicrobial agents and chemotherapy, Feb, Volume: 54, Issue:2	Identification of a plasmid-borne resistance gene cluster comprising the resistance genes erm(T), dfrK, and tet(L) in a porcine methicillin-resistant Staphylococcus aureus ST398 strain.
AID521067	Antibacterial activity against group 1-v2 PVL+ community-acquired methicillin-resistant Staphylococcus aureus ST 59 expressing SCCmec type X gene by agar dilution method	2008	Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3	Novel characteristics of community-acquired methicillin-resistant Staphylococcus aureus strains belonging to multilocus sequence type 59 in Taiwan.
AID533940	Antimicrobial activity against linezolid-resistant Enterococcus faecalis 411 harboring G2576U mutation in peptidyl transferase centre by broth microdilution method	2008	Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12	In vitro activity of TR-700, the antibacterial moiety of the prodrug TR-701, against linezolid-resistant strains.
AID525583	Antimicrobial activity against multidrug-resistant Macrococcus caseolyticus JCSC5402 containing plasmid pMCCL2 which carries transposon containing (mecA(m)-mecR1(m)-mecI(m)-blaZ(m)) complex isolated from chicken by agar dilution method	2010	Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4	Staphylococcal cassette chromosome mec-like element in Macrococcus caseolyticus.
AID528524	Antimicrobial activity against penicillin-resistant Streptococcus agalactiae B1 by agar dilution method	2008	Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8	First molecular characterization of group B streptococci with reduced penicillin susceptibility.
AID545974	Antimicrobial activity against methicillin-resistant Staphylococcus aureus 16689 by broth dilution method	2010	Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8	Identification of a novel transposon (Tn6072) and a truncated staphylococcal cassette chromosome mec element in methicillin-resistant Staphylococcus aureus ST239.
AID1517086	Antibacterial activity against Staphylococcus aureus ATCC 29213 assessed as reduction in bacterial growth at MIC measured after 15 passages	2019	European journal of medicinal chemistry, Dec-01, Volume: 183	Two optimized antimicrobial peptides with therapeutic potential for clinical antibiotic-resistant Staphylococcus aureus.
AID425867	Antimicrobial activity against Carnobacterium divergens BM4490 expressing beta-lactamase CAD1 at 0.5 McFarland inoculum size by E-test	2008	Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2	Genetic and biochemical characterization of CAD-1, a chromosomally encoded new class A penicillinase from Carnobacterium divergens.
AID285923	Antimicrobial activity against methicillin-resistant Staphylococcus aureus ATCC 43300 in human monocyte-derived macrophages at 0.5 ug/ml assessed as bacterial viability after 24 hrs	2007	Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4	Antimicrobial activities of daptomycin, vancomycin, and oxacillin in human monocytes and of daptomycin in combination with gentamicin and/or rifampin in human monocytes and in broth against Staphylococcus aureus.
AID1524627	Antibacterial activity against methicillin-resistant Staphylococcus aureus CCARM 3506 after 24 hrs by microtiter ELISA	2019	Bioorganic & medicinal chemistry letters, 05-01, Volume: 29, Issue:9	Synthesis of novel dihydrotriazine derivatives bearing 1,3-diaryl pyrazole moieties as potential antibacterial agents.
AID548131	Antibacterial activity against Escherichia coli 1924 after 20 hrs by twofold serial dilution technique	2010	European journal of medicinal chemistry, Dec, Volume: 45, Issue:12	Synthesis of new chalcone derivatives containing a rhodanine-3-acetic acid moiety with potential anti-bacterial activity.
AID431097	Antibacterial activity against vancomycin-susceptible Staphylococcus aureus N315 harboring mutated graR gene after 48 hrs by agar dilution method	2008	Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1	Mutated response regulator graR is responsible for phenotypic conversion of Staphylococcus aureus from heterogeneous vancomycin-intermediate resistance to vancomycin-intermediate resistance.
AID574304	Antimicrobial activity against hospital-acquired pbp3/4-deficient Staphylococcus aureus COL serotype USA500 by microdilution method	2008	Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11	Staphylococcus aureus PBP4 is essential for beta-lactam resistance in community-acquired methicillin-resistant strains.
AID564820	Bactericidal activity against methicillin-susceptible Staphylococcus aureus after 24 hrs by plate counting method	2009	Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10	In vitro activities of panduratin A against clinical Staphylococcus strains.
AID323866	Antibacterial activity against methicillin-resistant Staphylococcus aureus 459 at pH 5.5	2007	Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5	Role of acidic pH in the susceptibility of intraphagocytic methicillin-resistant Staphylococcus aureus strains to meropenem and cloxacillin.
AID629346	Antibacterial activity against Mycobacterium luteum assessed as zone of inhibition at 0.01 mg/mL after 24 hrs by stiff-plate agar-diffusion method	2011	European journal of medicinal chemistry, Dec, Volume: 46, Issue:12	Synthesis and biological activity of novel N-cycloalkyl-(cycloalkylaryl)-2-[(3-R-2-oxo-2H-[1,2,4]triazino[2,3-c]quinazoline-6-yl)thio]acetamides.
AID565006	Antimicrobial activity against methicillin-susceptible coagulase-negative Staphylococcus epidermidis assessed as resistant isolates after 24 hrs by broth microdilution method	2009	Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10	In vitro activities of panduratin A against clinical Staphylococcus strains.
AID1428627	Antimycobacterial activity against Mycobacterium smegmatis MC2 155 after 3 days by broth macrodilution method	2017	European journal of medicinal chemistry, Feb-15, Volume: 127	Diaryltriazenes as antibacterial agents against methicillin resistant Staphylococcus aureus (MRSA) and Mycobacterium smegmatis.
AID1304338	Bactericidal activity against methicillin-resistant Staphylococcus aureus USA300 SF8300 after 18 to 20 hrs	2016	Bioorganic & medicinal chemistry letters, 07-01, Volume: 26, Issue:13	Caged xanthones: Potent inhibitors of global predominant MRSA USA300.
AID583689	Antimicrobial activity against methicillin-resistant Staphylococcus aureus N315deltaIP harboring hypothetical protein SA1826 14A mutant after 24 hrs by Etest method	2010	Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12	An RpoB mutation confers dual heteroresistance to daptomycin and vancomycin in Staphylococcus aureus.
AID1504826	Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC 33591 after 24 hrs by broth microdilution method	2017	Journal of natural products, 12-22, Volume: 80, Issue:12	Sulfur-Containing Aristoloxazines and Other Constituents of the Roots of Aristolochia orbicularis.
AID544593	Antibacterial activity against Staphylococcus aureus isolate 4666 by agar dilution method	2008	Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11	In vitro and in vivo evaluations of oxacillin efficiency against mecA-positive oxacillin-susceptible Staphylococcus aureus.
AID560517	Antimicrobial activity against SCCmec type II vancomycin-intermediate Staphylococcus aureus isolate 07b63 by agar dilution method	2009	Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9	Prevalence and characterization of heterogeneous vancomycin-intermediate Staphylococcus aureus isolates from 14 cities in China.
AID477411	Antibacterial activity against MBX-1090-resistant Staphylococcus aureus isolate d20A1 after 16 to 20 hrs by broth microdilution method	2010	Bioorganic & medicinal chemistry, Mar-15, Volume: 18, Issue:6	Efflux-mediated bis-indole resistance in Staphylococcus aureus reveals differential substrate specificities for MepA and MepR.
AID431095	Antibacterial activity against vancomycin-susceptible Staphylococcus aureus N315 harboring shuttle vector pYT3 after 48 hrs by agar dilution method	2008	Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1	Mutated response regulator graR is responsible for phenotypic conversion of Staphylococcus aureus from heterogeneous vancomycin-intermediate resistance to vancomycin-intermediate resistance.
AID1294664	Antimicrobial activity against methicillin-resistant Staphylococcus aureus isolate 10a after 24 hrs by agar plate dilution method	2016	European journal of medicinal chemistry, Jun-10, Volume: 115	Anti-methicillin resistant Staphylococcus aureus activity, synergism with oxacillin and molecular docking studies of metronidazole-triazole hybrids.
AID524265	Antibacterial activity against Escherichia coli NKE159 harboring deletion mutation in acrB, cpxAR protein and plasmid expressing nlpE gene	2010	Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5	Effect of NlpE overproduction on multidrug resistance in Escherichia coli.
AID405609	Decrease in SA2273 N315 gene expression in oxacillin-dependent methicillin-resistant Staphylococcus aureus 2884D isolate at 0.5 ug/ml by microarray-based transcriptional profiling relative to control	2007	Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7	Identification and phenotypic characterization of a beta-lactam-dependent, methicillin-resistant Staphylococcus aureus strain.
AID1294663	Antimicrobial activity against methicillin-resistant Staphylococcus aureus isolate 9a after 24 hrs by agar plate dilution method	2016	European journal of medicinal chemistry, Jun-10, Volume: 115	Anti-methicillin resistant Staphylococcus aureus activity, synergism with oxacillin and molecular docking studies of metronidazole-triazole hybrids.
AID356967	Antibacterial activity against vancomycin-resistant Enterococcus faecalis CKU-17 expressing VanB after 48 hrs by broth microdilution method	2002	Journal of natural products, Dec, Volume: 65, Issue:12	Antimicrobial activities of naphthazarins from Arnebia euchroma.
AID300058	Antibacterial activity against Bacillus cereus ATCC 6633 at 1 ug after 24 hrs by disc diffusion method	2007	Bioorganic & medicinal chemistry, Aug-01, Volume: 15, Issue:15	Synthesis, characterization and antimicrobial activity of new aliphatic sulfonamide.
AID761560	Antibacterial activity against Staphylococcus epidermidis 887E by M07-A9 CLSI method	2013	Bioorganic & medicinal chemistry letters, Aug-01, Volume: 23, Issue:15	Synthesis and antimicrobial activity of imidazole and pyridine appended cholestane-based conjugates.
AID581656	Antibacterial activity against revertant Staphylococcus aureus at pH 7.4 after 24 hrs by broth microdilution method	2009	Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4	Intracellular activity of antibiotics in a model of human THP-1 macrophages infected by a Staphylococcus aureus small-colony variant strain isolated from a cystic fibrosis patient: pharmacodynamic evaluation and comparison with isogenic normal-phenotype a
AID575144	Antimicrobial activity against methicillin-resistant Staphylococcus aureus isolate NRS1 by broth microdilution method	2010	Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9	Inhibition of antibiotic-resistant Staphylococcus aureus by the broad-spectrum dihydrofolate reductase inhibitor RAB1.
AID285345	Antibacterial activity against community acquired methicillin-resistant Staphylococcus aureus HT20041010 in Mueller-Hinton medium	2007	Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4	Effect of antibiotics on Staphylococcus aureus producing Panton-Valentine leukocidin.
AID1242588	Antibacterial activity against methicillin-resistant Staphylococcus aureus R306 clinical isolate after 20 to 24 hrs by CLSI method	2015	ACS medicinal chemistry letters, Jul-09, Volume: 6, Issue:7	Triazole-Linked Glycolipids Enhance the Susceptibility of MRSA to β-Lactam Antibiotics.
AID625292	Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) combined score	2011	PLoS computational biology, Dec, Volume: 7, Issue:12	Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
AID484702	Antimicrobial activity against methicillin-susceptible Staphylococcus aureus	2010	Bioorganic & medicinal chemistry letters, Jun-15, Volume: 20, Issue:12	Potent antimicrobial activity of 3-(4,5-diaryl-1H-imidazol-2-yl)-1H-indole derivatives against methicillin-resistant Staphylococcus aureus.
AID383179	Antimicrobial activity against methicillin-resistant Staphylococcus aureus ATCC 700787	2008	Journal of natural products, Apr, Volume: 71, Issue:4	Sesterterpenoids from the sponge Sarcotragus sp.
AID1870141	Antibacterial activity against wild type Staphylococcus aureus 4463/A assessed as reduction in microbial growth incubated for 24 hrs by microdilution assay	2022	Journal of medicinal chemistry, 07-28, Volume: 65, Issue:14	LEGO-Lipophosphonoxins: A Novel Approach in Designing Membrane Targeting Antimicrobials.
AID542385	Antimicrobial activity against methicillin-resistant Staphylococcus aureus ST398 expressing cfr, fexA, erm(A), tet(M) and mecA genes	2009	Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2	Methicillin-resistant and -susceptible Staphylococcus aureus strains of clonal lineages ST398 and ST9 from swine carry the multidrug resistance gene cfr.
AID573149	Antibacterial activity against vancomycin-susceptible Enterococcus faecalis by CLSI M7-A7 broth microdilution method	2008	Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9	In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States.
AID685406	Antibacterial activity against methicillin-resistant Staphylococcus aureus CCARM 3506 clinical isolate after 24 hrs by broth microdilution method	2012	European journal of medicinal chemistry, Oct, Volume: 56	Synthesis and antimicrobial evaluation of L-phenylalanine-derived C5-substituted rhodanine and chalcone derivatives containing thiobarbituric acid or 2-thioxo-4-thiazolidinone.
AID685405	Antibacterial activity against methicillin-resistant Staphylococcus aureus CCARM 3167 clinical isolate after 24 hrs by broth microdilution method	2012	European journal of medicinal chemistry, Oct, Volume: 56	Synthesis and antimicrobial evaluation of L-phenylalanine-derived C5-substituted rhodanine and chalcone derivatives containing thiobarbituric acid or 2-thioxo-4-thiazolidinone.
AID509046	Antibacterial activity against beta-lactamase positive SCCmec type 2 methicillin-resistant Staphylococcus aureus isolate 11521 by broth microdilution method	2010	Antimicrobial agents and chemotherapy, Feb, Volume: 54, Issue:2	Effects of ceftobiprole and oxacillin on mecA expression in methicillin-resistant Staphylococcus aureus clinical isolates.
AID429445	Antimicrobial activity against vancomycin-intermediate Staphylococcus aureus isolate 9	2009	Bioorganic & medicinal chemistry letters, Aug-15, Volume: 19, Issue:16	Isoplatensimycin: Synthesis and biological evaluation.
AID432807	Antimicrobial activity against SCCmec type 1 methicillin-resistant Staphylococcus aureus COL C245Td expressing symporter gene smr1 at 37 degC incubated for 24 hrs by E-test	2008	Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2	Role of a sodium-dependent symporter homologue in the thermosensitivity of beta-lactam antibiotic resistance and cell wall composition in Staphylococcus aureus.
AID574305	Antimicrobial activity against wild type hospital-acquired methicillin-resistant Staphylococcus aureus N315 serotype USA100 by microdilution method	2008	Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11	Staphylococcus aureus PBP4 is essential for beta-lactam resistance in community-acquired methicillin-resistant strains.
AID425866	Antimicrobial activity against Carnobacterium divergens BM4489 expressing beta-lactamase CAD1 at 3 McFarland inoculum size by E-test	2008	Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2	Genetic and biochemical characterization of CAD-1, a chromosomally encoded new class A penicillinase from Carnobacterium divergens.
AID1651725	Antibacterial activity against Methicillin-resistant Staphylococcus epidermidis MB165 after 24 hrs by microdilution assay	2020	Journal of natural products, 04-24, Volume: 83, Issue:4	Antibacterial and ATP Synthesis Modulating Compounds from
AID431105	Antibacterial activity against mutated graSR gene knockout vancomycin-susceptible Staphylococcus aureus N315 after 48 hrs by agar dilution method	2008	Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1	Mutated response regulator graR is responsible for phenotypic conversion of Staphylococcus aureus from heterogeneous vancomycin-intermediate resistance to vancomycin-intermediate resistance.
AID565009	Antimicrobial activity against methicillin-susceptible coagulase-negative Staphylococcus haemolyticus assessed as susceptible isolates after 24 hrs by broth microdilution method	2009	Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10	In vitro activities of panduratin A against clinical Staphylococcus strains.
AID405614	Decrease in histydyl tRNA synthetase SA1686 COL gene expression in oxacillin-dependent methicillin-resistant Staphylococcus aureus 2884D isolate at 0.5 ug/ml by microarray-based transcriptional profiling relative to control	2007	Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7	Identification and phenotypic characterization of a beta-lactam-dependent, methicillin-resistant Staphylococcus aureus strain.
AID1324843	Antimicrobial activity against Staphylococcus aureus ATCC 29213 by CLSI M07-A9 method	2016	Journal of natural products, 07-22, Volume: 79, Issue:7	Polybrominated Diphenyl Ethers: Structure Determination and Trends in Antibacterial Activity.
AID509052	Antibacterial activity against beta-lactamase positive SCCmec type 4a methicillin-resistant Staphylococcus aureus isolate 14154 by broth microdilution method	2010	Antimicrobial agents and chemotherapy, Feb, Volume: 54, Issue:2	Effects of ceftobiprole and oxacillin on mecA expression in methicillin-resistant Staphylococcus aureus clinical isolates.
AID533943	Antimicrobial activity against linezolid-resistant Enterococcus faecalis 414 harboring G2576U mutation in peptidyl transferase centre by broth microdilution method	2008	Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12	In vitro activity of TR-700, the antibacterial moiety of the prodrug TR-701, against linezolid-resistant strains.
AID584123	Antimicrobial activity against Staphylococcus aureus RN4220 carrying pAFS11-apmA, erm(B), tet(L), dfrK, aadD resistance genes by CLSI M31-A3 method	2011	Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1	Novel apramycin resistance gene apmA in bovine and porcine methicillin-resistant Staphylococcus aureus ST398 isolates.
AID750296	Bactericidal activity against Staphylococcus aureus isolate D20 derived from bone after 18 hrs by broth microdilution method	2013	European journal of medicinal chemistry, Jun, Volume: 64	Synthesis and evaluation of antimicrobial activity of hydrazones derived from 3-oxido-1H-imidazole-4-carbohydrazides.
AID1055333	Antibacterial activity against vancomycin-resistant Enterococcus faecalis W4138 assessed as growth inhibition after 18 hrs by agar dilution method	2013	Journal of natural products, Nov-22, Volume: 76, Issue:11	Identification of elaiophylin derivatives from the marine-derived actinomycete Streptomyces sp. 7-145 using PCR-based screening.
AID1242551	Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC 43300 assessed as growth inhibition at 2 ug/ml after 24 hrs by Epsilometer test	2015	ACS medicinal chemistry letters, Jul-09, Volume: 6, Issue:7	Triazole-Linked Glycolipids Enhance the Susceptibility of MRSA to β-Lactam Antibiotics.
AID544616	Antibacterial activity against Staphylococcus aureus isolate 6083 infected in Wistar rat thigh infection model assessed as bacterial load per gram of thigh at 200 mg/kg, sc administered 2 hrs postinfection and every 6 hrs thereafter for 1 day measured aft	2008	Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11	In vitro and in vivo evaluations of oxacillin efficiency against mecA-positive oxacillin-susceptible Staphylococcus aureus.
AID583691	Antimicrobial activity against methicillin-resistant Staphylococcus aureus 10*3d1 harboring hypothetical protein SA1826 14A mutant gene after 24 hrs by Etest method	2010	Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12	An RpoB mutation confers dual heteroresistance to daptomycin and vancomycin in Staphylococcus aureus.
AID524262	Antibacterial activity against Escherichia coli NKE155 harboring deletion mutation in acrB protein and plasmid expressing nlpE gene	2010	Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5	Effect of NlpE overproduction on multidrug resistance in Escherichia coli.
AID375938	Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC 33591 after 24 hrs by broth microdilution method	2006	Journal of natural products, Apr, Volume: 69, Issue:4	Antibacterial, partially acetylated oligorhamnosides from Cleistopholis patens.
AID529288	Antimicrobial activity against methicillin-resistant Staphylococcus aureus COL assessed as reduction in viable bacterial titer after 24 hrs in presence of 10 times compound MIC	2008	Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8	Comparative study of the susceptibilities of major epidemic clones of methicillin-resistant Staphylococcus aureus to oxacillin and to the new broad-spectrum cephalosporin ceftobiprole.
AID520728	Activity of Acinetobacter baumannii CIP7010 beta-lactamase assessed per mg of protein at 100 uM	2008	Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5	Carbapenem-resistant Acinetobacter baumannii isolates from Tunisia producing the OXA-58-like carbapenem-hydrolyzing oxacillinase OXA-97.
AID583688	Antimicrobial activity against methicillin-resistant Staphylococcus aureus N315deltaIP harboring rpoB A621E mutant gene after 24 hrs by Etest method	2010	Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12	An RpoB mutation confers dual heteroresistance to daptomycin and vancomycin in Staphylococcus aureus.
AID405606	Decrease in vraR gene expression in oxacillin-dependent methicillin-resistant Staphylococcus aureus 2884D isolate at 0.5 ug/ml by microarray-based transcriptional profiling relative to control	2007	Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7	Identification and phenotypic characterization of a beta-lactam-dependent, methicillin-resistant Staphylococcus aureus strain.
AID556040	Antimicrobial activity against erythromycin-resistant and rsbUVW-sigB operon deficient Staphylococcus aureus COL by broth microdilution method	2009	Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5	Functional characterization of the sigmaB-dependent yabJ-spoVG operon in Staphylococcus aureus: role in methicillin and glycopeptide resistance.
AID528522	Antimicrobial activity against Streptococcus pneumoniae ATCC 49619 by agar dilution method	2008	Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8	First molecular characterization of group B streptococci with reduced penicillin susceptibility.
AID1517073	Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC 18908 assessed as reduction in bacterial growth incubated for 24 hrs by serial dilution method	2019	European journal of medicinal chemistry, Dec-01, Volume: 183	Two optimized antimicrobial peptides with therapeutic potential for clinical antibiotic-resistant Staphylococcus aureus.
AID1759642	Antimicrobial activity against vancomycin-resistant Enterococcus faecium clinical isolate 1091720 by CLSI-based broth microdilution assay	2021	European journal of medicinal chemistry, Jul-05, Volume: 219	4-4-(Anilinomethyl)-3-[4-(trifluoromethyl)phenyl]-1H-pyrazol-1-ylbenzoic acid derivatives as potent anti-gram-positive bacterial agents.
AID564818	Antimicrobial activity against methicillin-resistant coagulase-negative Staphylococcus hominis assessed as resistant isolates after 24 hrs by broth microdilution method	2009	Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10	In vitro activities of panduratin A against clinical Staphylococcus strains.
AID1870152	Antibacterial activity against wild type Staphylococcus aureus 4738/B assessed as reduction in microbial growth incubated for 24 hrs by microdilution assay	2022	Journal of medicinal chemistry, 07-28, Volume: 65, Issue:14	LEGO-Lipophosphonoxins: A Novel Approach in Designing Membrane Targeting Antimicrobials.
AID422497	Ratio of Kcat to Km of Carnobacterium divergens BM4489 penicillinase Cad-1	2008	Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2	Genetic and biochemical characterization of CAD-1, a chromosomally encoded new class A penicillinase from Carnobacterium divergens.
AID325158	Antimicrobial activity against Haemophilus parasuis BB 1025	2007	Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6	Beta-lactam resistance in Haemophilus parasuis Is mediated by plasmid pB1000 bearing blaROB-1.
AID529137	Antimicrobial activity against methicillin-resistant Staphylococcus aureus HAR22 assessed as concentration required for minimum inhibition of oxacillin-resistant subpopulation growth by Etest	2008	Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8	Comparative study of the susceptibilities of major epidemic clones of methicillin-resistant Staphylococcus aureus to oxacillin and to the new broad-spectrum cephalosporin ceftobiprole.
AID285925	Antimicrobial activity against methicillin-resistant Staphylococcus aureus ATCC 43300 in human monocyte-derived macrophages at 2.5 ug/ml assessed as bacterial viability after 4 hrs	2007	Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4	Antimicrobial activities of daptomycin, vancomycin, and oxacillin in human monocytes and of daptomycin in combination with gentamicin and/or rifampin in human monocytes and in broth against Staphylococcus aureus.
AID540213	Half life in human after iv administration	2008	Drug metabolism and disposition: the biological fate of chemicals, Jul, Volume: 36, Issue:7	Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
AID548475	Antibacterial activity against vancomycin-susceptible Staphylococcus aureus Mu50omega expressing vraSm, graRm mutant gene after 48 hrs by Etest	2009	Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3	Contribution of vraSR and graSR point mutations to vancomycin resistance in vancomycin-intermediate Staphylococcus aureus.
AID721789	Antibacterial activity against vancomycin-resistant Enterococcus faecalis ATCC 51575 assessed as growth inhibition after 24 hrs by CLSI broth microdilution method	2013	European journal of medicinal chemistry, Feb, Volume: 60	Antimicrobial activity of various 4- and 5-substituted 1-phenylnaphthalenes.
AID726492	Antibacterial activity against methicillin-resistant Staphylococcus aureus CCARM 3506 assessed as bacterial growth inhibition measured during 24 hrs incubation at 37 degC by two-fold serial dilution technique	2013	European journal of medicinal chemistry, Feb, Volume: 60	Synthesis and antibacterial evaluation of rhodanine-based 5-aryloxy pyrazoles against selected methicillin resistant and quinolone-resistant Staphylococcus aureus (MRSA and QRSA).
AID584303	Antibacterial activity against methicillin-resistant mecA-positive Staphylococcus sciuri subsp. rodentium ATCC 700061T by agar dilution method	2010	Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10	Origin and molecular evolution of the determinant of methicillin resistance in staphylococci.
AID325449	Antibacterial activity against Staphylococcus aureus ATCC 3556 after 14 to 16 hrs by broth dilution method	2007	Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6	Polyamine effects on antibiotic susceptibility in bacteria.
AID574299	Antimicrobial activity against community-acquired pbp4-deficient Staphylococcus aureus USA300 by microdilution method	2008	Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11	Staphylococcus aureus PBP4 is essential for beta-lactam resistance in community-acquired methicillin-resistant strains.
AID750342	Antibacterial activity against Proteus vulgaris ATCC 49990 assessed as growth inhibition after 18 hrs by broth microdilution method	2013	European journal of medicinal chemistry, Jun, Volume: 64	Synthesis and evaluation of antimicrobial activity of hydrazones derived from 3-oxido-1H-imidazole-4-carbohydrazides.
AID1870154	Antibacterial activity against wild type Staphylococcus aureus 4679/B assessed as reduction in microbial growth incubated for 24 hrs by microdilution assay	2022	Journal of medicinal chemistry, 07-28, Volume: 65, Issue:14	LEGO-Lipophosphonoxins: A Novel Approach in Designing Membrane Targeting Antimicrobials.
AID402929	Antimicrobial activity against methicillin-resistant Staphylococcus aureus 5 after 24 hrs	2004	Journal of natural products, Jun, Volume: 67, Issue:6	New stilbene derivatives from Calligonum leucocladum.
AID285939	Antimicrobial activity against methicillin-susceptible Staphylococcus aureus ATCC 29213 in human monocyte-derived macrophages at 5 ug/ml assessed as bacterial viability after 2 hrs	2007	Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4	Antimicrobial activities of daptomycin, vancomycin, and oxacillin in human monocytes and of daptomycin in combination with gentamicin and/or rifampin in human monocytes and in broth against Staphylococcus aureus.
AID548472	Antibacterial activity against vancomycin-susceptible Staphylococcus aureus Mu50omega after 48 hrs by Etest	2009	Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3	Contribution of vraSR and graSR point mutations to vancomycin resistance in vancomycin-intermediate Staphylococcus aureus.
AID405593	Increase in SAV1002 Mu50 N315 gene expression in oxacillin-dependent methicillin-resistant Staphylococcus aureus 2884D isolate at 0.5 ug/ml by microarray-based transcriptional profiling relative to control	2007	Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7	Identification and phenotypic characterization of a beta-lactam-dependent, methicillin-resistant Staphylococcus aureus strain.
AID1055329	Antibacterial activity against apramycin-resistant Micrococcus luteus ATCC 10240 assessed as growth inhibition after 18 hrs by agar dilution method	2013	Journal of natural products, Nov-22, Volume: 76, Issue:11	Identification of elaiophylin derivatives from the marine-derived actinomycete Streptomyces sp. 7-145 using PCR-based screening.
AID422498	Ratio of Kcat to Km of Carnobacterium divergens BM4489 penicillinase Cad-1 relative to benzyl-penicillin	2008	Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2	Genetic and biochemical characterization of CAD-1, a chromosomally encoded new class A penicillinase from Carnobacterium divergens.
AID1638999	Antibacterial activity against Staphylococcus epidermidis ATCC 35984 after 24 hrs by resazurin dye based fluorescence assay	2019	Journal of natural products, 04-26, Volume: 82, Issue:4	Mindapyrroles A-C, Pyoluteorin Analogues from a Shipworm-Associated Bacterium.
AID609226	Antibacterial activity against 10'5 CFU/mL quinolone-resistant Staphylococcus aureus CCARM 3519 assessed as inhibition of bacterial growth after 24 hrs by microtiter enzyme-linked immunosorbent assay	2011	European journal of medicinal chemistry, Aug, Volume: 46, Issue:8	Synthesis of new chalcone derivatives bearing 2,4-thiazolidinedione and benzoic acid moieties as potential anti-bacterial agents.
AID530763	Induction of Ppbp2::lacZ gene expression in Staphylococcus aureus SH1000 at 0.3 ug/ml after 0.5 hrs by beta-galactosidase reporter gene assay relative to untreated control	2008	Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8	Staphylococcus aureus cell wall stress stimulon gene-lacZ fusion strains: potential for use in screening for cell wall-active antimicrobials.
AID530745	Induction of PlytR::lacZ gene expression in Staphylococcus aureus SH1000 at 1.2 ug/ml after 2 hrs by beta-galactosidase reporter gene assay relative to untreated control	2008	Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8	Staphylococcus aureus cell wall stress stimulon gene-lacZ fusion strains: potential for use in screening for cell wall-active antimicrobials.
AID545977	Antimicrobial activity against methicillin-resistant Staphylococcus aureus 16695 by broth dilution method	2010	Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8	Identification of a novel transposon (Tn6072) and a truncated staphylococcal cassette chromosome mec element in methicillin-resistant Staphylococcus aureus ST239.
AID1651737	Antibacterial activity against Enterococcus faecalis MB76 after 24 hrs by microdilution assay	2020	Journal of natural products, 04-24, Volume: 83, Issue:4	Antibacterial and ATP Synthesis Modulating Compounds from
AID559506	Antibacterial activity against Staphylococcus lugdunensis assessed as percent susceptible isolates by CLSI M100-S18 method	2009	Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8	Besifloxacin, a novel fluoroquinolone, has broad-spectrum in vitro activity against aerobic and anaerobic bacteria.
AID529111	Antimicrobial activity against methicillin-resistant Staphylococcus aureus E2125 by Etest	2008	Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8	Comparative study of the susceptibilities of major epidemic clones of methicillin-resistant Staphylococcus aureus to oxacillin and to the new broad-spectrum cephalosporin ceftobiprole.
AID1853472	Antibacterial activity against methicillin-resistant Staphylococcus aureus ST239 (ARLG 1665) assessed as bacterial growth inhibition incubated for 18 to 20 hrs by CLSI based broth microdilution assay	2021	RSC medicinal chemistry, Nov-17, Volume: 12, Issue:11	SF
AID570771	Antimicrobial activity against hospital-acquired pbp4-deficient Staphylococcus aureus Mu50 serotype USA100 by microdilution method	2008	Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11	Staphylococcus aureus PBP4 is essential for beta-lactam resistance in community-acquired methicillin-resistant strains.
AID759321	Antibacterial activity against quinolone-resistant Staphylococcus aureus CCARM 3519 after 24 hrs by broth microdilution method	2013	Bioorganic & medicinal chemistry letters, Aug-01, Volume: 23, Issue:15	Synthesis and biological evaluation of rhodanine derivatives bearing a quinoline moiety as potent antimicrobial agents.
AID1294659	Antimicrobial activity against methicillin-resistant Staphylococcus aureus isolate 5a after 24 hrs by agar plate dilution method	2016	European journal of medicinal chemistry, Jun-10, Volume: 115	Anti-methicillin resistant Staphylococcus aureus activity, synergism with oxacillin and molecular docking studies of metronidazole-triazole hybrids.
AID570777	Antimicrobial activity against wild type community-acquired methicillin-resistant Staphylococcus aureus MW2 (USA400) after 48 hrs by microdilution method	2008	Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11	Staphylococcus aureus PBP4 is essential for beta-lactam resistance in community-acquired methicillin-resistant strains.
AID340889	Antimicrobial activity against Escherichia coli JM83 by serial dilution method	2007	Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8	Cytoplasmic-membrane anchoring of a class A beta-lactamase and its capacity in manifesting antibiotic resistance.
AID405587	Decrease in PBP2 gene expression in oxacillin-dependent methicillin-resistant Staphylococcus aureus 2884D isolate by RT-PCR	2007	Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7	Identification and phenotypic characterization of a beta-lactam-dependent, methicillin-resistant Staphylococcus aureus strain.
AID629345	Antibacterial activity against Staphylococcus aureus assessed as zone of inhibition at 0.01 mg/mL after 24 hrs by stiff-plate agar-diffusion method	2011	European journal of medicinal chemistry, Dec, Volume: 46, Issue:12	Synthesis and biological activity of novel N-cycloalkyl-(cycloalkylaryl)-2-[(3-R-2-oxo-2H-[1,2,4]triazino[2,3-c]quinazoline-6-yl)thio]acetamides.
AID548473	Antibacterial activity against vancomycin-susceptible Staphylococcus aureus Mu50omega expressing vraSn mutant gene after 48 hrs by Etest	2009	Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3	Contribution of vraSR and graSR point mutations to vancomycin resistance in vancomycin-intermediate Staphylococcus aureus.
AID405586	Induction of PBP2 gene expression in methicillin-resistant Staphylococcus aureus 2884 isolate by RT-PCR	2007	Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7	Identification and phenotypic characterization of a beta-lactam-dependent, methicillin-resistant Staphylococcus aureus strain.
AID584298	Antibacterial activity against methicillin-resistant mecA-positive Staphylococcus fleurettii SFMP08 by agar dilution method	2010	Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10	Origin and molecular evolution of the determinant of methicillin resistance in staphylococci.
AID1209736	Inhibition of human OAT3 expressed in CHO cells assessed as inhibition of fluorescein uptake at 500 uM over 20 mins relative to untreated-control	2013	Drug metabolism and disposition: the biological fate of chemicals, Apr, Volume: 41, Issue:4	Organic anion transporter 3 interacts selectively with lipophilic β-lactam antibiotics.
AID341373	Antibacterial activity against Staphylococcus aureus by manual microdilution technique	2007	Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8	Dexamethasone as adjuvant therapy to moxifloxacin attenuates valve destruction in experimental aortic valve endocarditis due to Staphylococcus aureus.
AID750308	Antibacterial activity against Staphylococcus aureus isolate D20 derived from bone assessed as growth inhibition after 18 hrs by broth microdilution method	2013	European journal of medicinal chemistry, Jun, Volume: 64	Synthesis and evaluation of antimicrobial activity of hydrazones derived from 3-oxido-1H-imidazole-4-carbohydrazides.
AID750313	Antibacterial activity against Staphylococcus aureus isolate F7 derived from ulcer and furuncle assessed as growth inhibition after 18 hrs by broth microdilution method	2013	European journal of medicinal chemistry, Jun, Volume: 64	Synthesis and evaluation of antimicrobial activity of hydrazones derived from 3-oxido-1H-imidazole-4-carbohydrazides.
AID1055342	Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC 33591 assessed as growth inhibition after 18 hrs by agar dilution method	2013	Journal of natural products, Nov-22, Volume: 76, Issue:11	Identification of elaiophylin derivatives from the marine-derived actinomycete Streptomyces sp. 7-145 using PCR-based screening.
AID396027	Antibacterial activity against drug-resistant Enterobacter cloacae EcDC64 isolate expressing AcrAB-TolC efflux pump in presence of 20 ug/ml efflux pump inhibitor Phe-Arg-beta-naphthylamide by Etest	2007	Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9	Cloning, nucleotide sequencing, and analysis of the AcrAB-TolC efflux pump of Enterobacter cloacae and determination of its involvement in antibiotic resistance in a clinical isolate.
AID524263	Antibacterial activity against Escherichia coli NKE127 harboring deletion mutation in acrB and cpxAR protein	2010	Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5	Effect of NlpE overproduction on multidrug resistance in Escherichia coli.
AID1870153	Antibacterial activity against wild type Staphylococcus aureus 4461/A assessed as reduction in microbial growth incubated for 24 hrs by microdilution assay	2022	Journal of medicinal chemistry, 07-28, Volume: 65, Issue:14	LEGO-Lipophosphonoxins: A Novel Approach in Designing Membrane Targeting Antimicrobials.
AID1294719	Bactericidal activity against methicillin-resistant Staphylococcus aureus isolate 1a assessed as reduction in colony counts at 32 ug/ml after 20 hrs by pour plate method (Rvb = 12.73 +/- 0.223 log10CFU/ml)	2016	European journal of medicinal chemistry, Jun-10, Volume: 115	Anti-methicillin resistant Staphylococcus aureus activity, synergism with oxacillin and molecular docking studies of metronidazole-triazole hybrids.
AID520729	Activity of Acinetobacter baumannii CIP7010 beta-lactamase OXA-97 assessed per mg of protein at 100 uM	2008	Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5	Carbapenem-resistant Acinetobacter baumannii isolates from Tunisia producing the OXA-58-like carbapenem-hydrolyzing oxacillinase OXA-97.
AID584296	Antibacterial activity against methicillin-resistant mecA-positive Staphylococcus fleurettii SFMP06 by agar dilution method	2010	Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10	Origin and molecular evolution of the determinant of methicillin resistance in staphylococci.
AID1079948	Times to onset, minimal and maximal, observed in the indexed observations. [column 'DELAI' in source]
AID429359	Antimicrobial activity against methicillin-susceptible Staphylococcus aureus isolate 3	2009	Bioorganic & medicinal chemistry letters, Aug-15, Volume: 19, Issue:16	Isoplatensimycin: Synthesis and biological evaluation.
AID520870	Antibacterial activity against methicillin-resistant mecA-positive Staphylococcus saprophyticus isolate TSU47 isolated from genitourinary tracts of acute cystitis patient after 24 hrs at 35 degC by agar dilution method	2008	Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6	Methicillin-resistant Staphylococcus saprophyticus isolates carrying staphylococcal cassette chromosome mec have emerged in urogenital tract infections.
AID1827144	Antibacterial activity against methicillin-resistant Staphylococcus aureus USA100 assessed as inhibition of bacterial growth after 18 hrs in presence of oxacillin by CLSI protocol based broth microdilution assay	2022	ACS medicinal chemistry letters, Mar-10, Volume: 13, Issue:3	Identification and Evaluation of Brominated Carbazoles as a Novel Antibiotic Adjuvant Scaffold in MRSA.
AID637196	Antibacterial activity against Escherichia coli CCARM 1924 after 20 hrs by twofold serial dilution technique	2012	European journal of medicinal chemistry, Feb, Volume: 48	Synthesis of novel 1,3-diaryl pyrazole derivatives bearing rhodanine-3-fatty acid moieties as potential antibacterial agents.
AID525581	Activity of Beta-lactamase OXA-1 expressed in Escherichia coli BL21 (DE3)	2010	Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4	Penicillin sulfone inhibitors of class D beta-lactamases.
AID718415	Antibacterial activity against log-phase methicillin-resistant Staphylococcus aureus ATCC 33591 assessed as growth inhibition after 24 hrs by broth microdilution method	2012	Bioorganic & medicinal chemistry, Dec-15, Volume: 20, Issue:24	3-Phenyl substituted 6,7-dimethoxyisoquinoline derivatives as FtsZ-targeting antibacterial agents.
AID544610	Antibacterial activity against mecA-negative Staphylococcus aureus isolate 29213 assessed as reduction in bacterial count at 20 ug/ml after 24 hrs by time-kill assay	2008	Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11	In vitro and in vivo evaluations of oxacillin efficiency against mecA-positive oxacillin-susceptible Staphylococcus aureus.
AID1651731	Antibacterial activity against Staphylococcus lugdunensis MB96 after 24 hrs by microdilution assay	2020	Journal of natural products, 04-24, Volume: 83, Issue:4	Antibacterial and ATP Synthesis Modulating Compounds from
AID1055334	Antibacterial activity against vancomycin-resistant Enterococcus faecalis ATCC 51299 assessed as growth inhibition after 18 hrs by agar dilution method	2013	Journal of natural products, Nov-22, Volume: 76, Issue:11	Identification of elaiophylin derivatives from the marine-derived actinomycete Streptomyces sp. 7-145 using PCR-based screening.
AID475621	Antimicrobial activity against vancomycin-resistant Enterococcus faecalis isolate 13	2010	Bioorganic & medicinal chemistry letters, Apr-01, Volume: 20, Issue:7	7-Phenylplatensimycin and 11-methyl-7-phenylplatensimycin: more potent analogs of platensimycin.
AID581655	Antibacterial activity against Staphylococcus aureus SCV isolated from cystic fibrosis patient at pH 7.4 after 48 hrs by broth microdilution method in presence of thymidine	2009	Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4	Intracellular activity of antibiotics in a model of human THP-1 macrophages infected by a Staphylococcus aureus small-colony variant strain isolated from a cystic fibrosis patient: pharmacodynamic evaluation and comparison with isogenic normal-phenotype a
AID545976	Antimicrobial activity against methicillin-resistant Staphylococcus aureus 16692 by broth dilution method	2010	Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8	Identification of a novel transposon (Tn6072) and a truncated staphylococcal cassette chromosome mec element in methicillin-resistant Staphylococcus aureus ST239.
AID523273	Antimicrobial activity against Escherichia coli HN1157/pHSG576oxa7	2010	Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5	Kinetic parameters of efflux of penicillins by the multidrug efflux transporter AcrAB-TolC of Escherichia coli.
AID584485	Antibacterial activity against mecA-negative Staphylococcus lentus ATCC 29070T by agar dilution method	2010	Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10	Origin and molecular evolution of the determinant of methicillin resistance in staphylococci.
AID421758	Antibacterial activity against Mycobacterium smegmatis mc2 2700 after 72 hrs	2009	Journal of natural products, Mar-27, Volume: 72, Issue:3	Bioactive pyridine-N-oxide disulfides from Allium stipitatum.
AID519636	Activity of beta-lactamase FUS1 assessed as compound hydrolysis by spectrophotometry relative to benzyl-penicillin	2008	Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4	Genetic and biochemical characterization of OXA-63, a new class D beta-lactamase from Brachyspira pilosicoli BM4442.
AID739303	Antibacterial activity against vancomycin-resistant Enterococcus faecalis ATCC 51575 assessed as growth inhibition by CLSI broth microdilution method	2013	Bioorganic & medicinal chemistry letters, Apr-01, Volume: 23, Issue:7	Substituted 1,6-diphenylnaphthalenes as FtsZ-targeting antibacterial agents.
AID1651730	Antibacterial activity against Staphylococcus simulans MB94 after 24 hrs by microdilution assay	2020	Journal of natural products, 04-24, Volume: 83, Issue:4	Antibacterial and ATP Synthesis Modulating Compounds from
AID567456	Antimicrobial activity against methicillin-resistant Staphylococcus aureus CGK8 by Etest method	2010	Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9	Development of daptomycin nonsusceptibility with heterogeneous vancomycin-intermediate resistance and oxacillin susceptibility in methicillin-resistant Staphylococcus aureus during high-dose daptomycin treatment.
AID545955	Antimicrobial activity against methicillin-resistant Staphylococcus aureus 16658 by broth dilution method	2010	Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8	Identification of a novel transposon (Tn6072) and a truncated staphylococcal cassette chromosome mec element in methicillin-resistant Staphylococcus aureus ST239.
AID575414	Antimicrobial activity against anrB-deficient Listeria monocytogenes EGD-e at 1 ug after 16 hrs by disk diffusion assay	2010	Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10	The ABC transporter AnrAB contributes to the innate resistance of Listeria monocytogenes to nisin, bacitracin, and various beta-lactam antibiotics.
AID1869530	Antibacterial activity against beta-lactamase-producing Morganella morganii ATCC25830 measured after 24 hrs by broth microdilution method
AID432973	Antimicrobial activity against SCCmec type 3 methicillin-resistant Staphylococcus aureus COL 301 expressing symporter gene smr1 at 37 degC incubated for 24 hrs by E-test	2008	Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2	Role of a sodium-dependent symporter homologue in the thermosensitivity of beta-lactam antibiotic resistance and cell wall composition in Staphylococcus aureus.
AID519461	Antimicrobial activity against oxacillin sensitive Staphylococcus aureus isolate 450MHomoex with SCCmec excised genotype by broth microdilution method	2008	Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4	Spontaneous deletion of the methicillin resistance determinant, mecA, partially compensates for the fitness cost associated with high-level vancomycin resistance in Staphylococcus aureus.
AID761558	Antibacterial activity against Enterococcus faecalis ATCC 29212 by M07-A9 CLSI method	2013	Bioorganic & medicinal chemistry letters, Aug-01, Volume: 23, Issue:15	Synthesis and antimicrobial activity of imidazole and pyridine appended cholestane-based conjugates.
AID1853611	Antibacterial activity against Enterococcus faecium clinical isolate 1089544 assessed as inhibition of bacterial growth by CLSI protocol based broth microdilution method	2021	RSC medicinal chemistry, Oct-20, Volume: 12, Issue:10	Design, synthesis, and antibacterial activity of
AID1304320	Antibacterial activity against methicillin-susceptible Staphylococcus aureus ATCC 25923 assessed as zone of inhibition at 1 ug after 18 hrs by disk diffusion method	2016	Bioorganic & medicinal chemistry letters, 07-01, Volume: 26, Issue:13	Caged xanthones: Potent inhibitors of global predominant MRSA USA300.
AID519453	Antimicrobial activity against homotypic oxacillin resistant and vancomycin resistant Staphylococcus aureus isolate 3130V32 by broth microdilution method	2008	Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4	Spontaneous deletion of the methicillin resistance determinant, mecA, partially compensates for the fitness cost associated with high-level vancomycin resistance in Staphylococcus aureus.
AID530769	Antimicrobial activity against beta-lactamase producing Staphylococcus aureus SH1000	2008	Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8	Staphylococcus aureus cell wall stress stimulon gene-lacZ fusion strains: potential for use in screening for cell wall-active antimicrobials.
AID545967	Antimicrobial activity against methicillin-resistant Staphylococcus aureus 16702 by broth dilution method	2010	Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8	Identification of a novel transposon (Tn6072) and a truncated staphylococcal cassette chromosome mec element in methicillin-resistant Staphylococcus aureus ST239.
AID425864	Antimicrobial activity against Carnobacterium divergens CIP101029 at 3 McFarland inoculum size by E-test	2008	Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2	Genetic and biochemical characterization of CAD-1, a chromosomally encoded new class A penicillinase from Carnobacterium divergens.
AID584480	Antibacterial activity against mecA-negative Staphylococcus vitulinus SVMN10 by agar dilution method	2010	Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10	Origin and molecular evolution of the determinant of methicillin resistance in staphylococci.
AID750331	Bactericidal activity against Staphylococcus epidermidis ATCC 12228 after 18 hrs by broth microdilution method	2013	European journal of medicinal chemistry, Jun, Volume: 64	Synthesis and evaluation of antimicrobial activity of hydrazones derived from 3-oxido-1H-imidazole-4-carbohydrazides.
AID556038	Antimicrobial activity against methicillin- and tetracycline resistant Staphylococcus aureus COL by broth microdilution method	2009	Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5	Functional characterization of the sigmaB-dependent yabJ-spoVG operon in Staphylococcus aureus: role in methicillin and glycopeptide resistance.
AID542614	Antimicrobial activity against Streptococcus pneumoniae R6 harboring PBP2x T338P mutant gene after 48 hrs by agar dilution method	2009	Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3	An important site in PBP2x of penicillin-resistant clinical isolates of Streptococcus pneumoniae: mutational analysis of Thr338.
AID544617	Antibacterial activity against Staphylococcus aureus isolate 2712 infected in Wistar rat thigh infection model assessed as bacterial load per gram of thigh at 200 mg/kg, sc administered 2 hrs postinfection and every 6 hrs thereafter for 1 day measured aft	2008	Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11	In vitro and in vivo evaluations of oxacillin efficiency against mecA-positive oxacillin-susceptible Staphylococcus aureus.
AID509051	Antibacterial activity against beta-lactamase positive SCCmec type 4a methicillin-resistant Staphylococcus aureus isolate 14145 by broth microdilution method	2010	Antimicrobial agents and chemotherapy, Feb, Volume: 54, Issue:2	Effects of ceftobiprole and oxacillin on mecA expression in methicillin-resistant Staphylococcus aureus clinical isolates.
AID544618	Antibacterial activity against Staphylococcus aureus isolate 29213 infected in Wistar rat thigh infection model assessed as bacterial load per gram of thigh at 200 mg/kg, sc administered 2 hrs postinfection and every 6 hrs thereafter for 1 day measured af	2008	Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11	In vitro and in vivo evaluations of oxacillin efficiency against mecA-positive oxacillin-susceptible Staphylococcus aureus.
AID508834	Induction of mecA gene expression in beta-lactamase positive SCCmec type 1 methicillin-resistant Staphylococcus aureus isolate 12192 at MIC after 1 hr by multiplex PCR method	2010	Antimicrobial agents and chemotherapy, Feb, Volume: 54, Issue:2	Effects of ceftobiprole and oxacillin on mecA expression in methicillin-resistant Staphylococcus aureus clinical isolates.
AID565013	Antimicrobial activity against methicillin-susceptible coagulase-negative Staphylococcus simulans assessed as susceptible isolates after 24 hrs by broth microdilution method	2009	Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10	In vitro activities of panduratin A against clinical Staphylococcus strains.
AID545950	Antimicrobial activity against methicillin-resistant Staphylococcus aureus 16646 by broth dilution method	2010	Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8	Identification of a novel transposon (Tn6072) and a truncated staphylococcal cassette chromosome mec element in methicillin-resistant Staphylococcus aureus ST239.
AID573123	Antibacterial activity against coagulase-negative and oxacillin-resistant Staphylococcus aureus assessed as susceptible isolates by CLSI M7-A7 broth microdilution method	2008	Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9	In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States.
AID1517068	Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC 18466 assessed as reduction in bacterial growth incubated for 24 hrs by serial dilution method	2019	European journal of medicinal chemistry, Dec-01, Volume: 183	Two optimized antimicrobial peptides with therapeutic potential for clinical antibiotic-resistant Staphylococcus aureus.
AID525143	Antimicrobial activity against linezolid-resistant Staphylococcus aureus isolate 004-737X expressing cfr and ermA gene isolated from paraplegic patient by broth microdilution method	2008	Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6	First report of cfr-mediated resistance to linezolid in human staphylococcal clinical isolates recovered in the United States.
AID667563	Antibacterial activity against methicillin-resistant Staphylococcus aureus CCARM 3506 after 24 hrs by two-fold serial dilution method	2012	European journal of medicinal chemistry, Aug, Volume: 54	Synthesis and bioactivity evaluation of rhodanine derivatives as potential anti-bacterial agents.
AID431106	Antibacterial activity against heterogeneous vancomycin-intermediate Staphylococcus aureus Mu3 after 24 hrs by agar dilution method	2008	Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1	Mutated response regulator graR is responsible for phenotypic conversion of Staphylococcus aureus from heterogeneous vancomycin-intermediate resistance to vancomycin-intermediate resistance.
AID529125	Antimicrobial activity against methicillin-resistant Staphylococcus aureus BK2529 assessed as concentration required for bacterial subpopulation growth	2008	Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8	Comparative study of the susceptibilities of major epidemic clones of methicillin-resistant Staphylococcus aureus to oxacillin and to the new broad-spectrum cephalosporin ceftobiprole.
AID402932	Antimicrobial activity against methicillin-resistant Staphylococcus aureus COL after 24 hrs	2004	Journal of natural products, Jun, Volume: 67, Issue:6	New stilbene derivatives from Calligonum leucocladum.
AID584300	Antibacterial activity against mecA-negative Staphylococcus fleurettii SFMN02 by agar dilution method	2010	Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10	Origin and molecular evolution of the determinant of methicillin resistance in staphylococci.
AID424420	Antibacterial activity against vancomycin-resistant Staphylococcus aureus HIP14300 isolated from patients foot wound by broth microdilution method	2008	Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2	Vancomycin-resistant Staphylococcus aureus isolates associated with Inc18-like vanA plasmids in Michigan.
AID574297	Antimicrobial activity against community-acquired pbp3/4-deficient Staphylococcus aureus MW2 ex serotype USA400 by microdilution method	2008	Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11	Staphylococcus aureus PBP4 is essential for beta-lactam resistance in community-acquired methicillin-resistant strains.
AID581671	Antibacterial activity against normal phenotype Staphylococcus aureus in cation-adjusted MH 2 broth at pH 5.5 after 24 hrs by broth microdilution method	2009	Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4	Intracellular activity of antibiotics in a model of human THP-1 macrophages infected by a Staphylococcus aureus small-colony variant strain isolated from a cystic fibrosis patient: pharmacodynamic evaluation and comparison with isogenic normal-phenotype a
AID519634	Ratio of Kcat to Km for beta-lactamase FUS1 assessed as compound hydrolysis by spectrophotometry	2008	Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4	Genetic and biochemical characterization of OXA-63, a new class D beta-lactamase from Brachyspira pilosicoli BM4442.
AID625283	Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for elevated liver function tests	2011	PLoS computational biology, Dec, Volume: 7, Issue:12	Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
AID571765	Antimicrobial activity against Escherichia coli K-12 3-AG300 harboring AcrB-615-628MexB mutant gene	2009	Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1	Site-directed mutagenesis reveals amino acid residues in the Escherichia coli RND efflux pump AcrB that confer macrolide resistance.
AID632947	Antistaphylococcal activity against epidemic Staphylococcus aureus isolate 16 by CLSI broth microplate assay	2011	Bioorganic & medicinal chemistry letters, Dec-01, Volume: 21, Issue:23	Anti-staphylococcal activity and β-lactam resistance attenuating capacity of structural analogues of (-)-epicatechin gallate.
AID560507	Antimicrobial activity against SCCmec type III vancomycin-intermediate Staphylococcus aureus isolate b2k3421 by agar dilution method	2009	Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9	Prevalence and characterization of heterogeneous vancomycin-intermediate Staphylococcus aureus isolates from 14 cities in China.
AID424424	Antibacterial activity against vancomycin-resistant Staphylococcus aureus AIS2006032 isolated from patients foot wound by broth microdilution method	2008	Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2	Vancomycin-resistant Staphylococcus aureus isolates associated with Inc18-like vanA plasmids in Michigan.
AID1870157	Antibacterial activity against wild type Staphylococcus aureus 5079/C assessed as reduction in microbial growth incubated for 24 hrs by microdilution assay	2022	Journal of medicinal chemistry, 07-28, Volume: 65, Issue:14	LEGO-Lipophosphonoxins: A Novel Approach in Designing Membrane Targeting Antimicrobials.
AID1818976	Antibacterial activity against Pseudomonas aeruginosa ATCC 10145 assessed as bacterial clearance incubated for 6 to 24 hrs by microbroth dilution method	2022	Journal of medicinal chemistry, 01-13, Volume: 65, Issue:1	Discovery of
AID1870160	Antibacterial activity against wild type Staphylococcus aureus 77/CF assessed as reduction in microbial growth incubated for 24 hrs by microdilution assay	2022	Journal of medicinal chemistry, 07-28, Volume: 65, Issue:14	LEGO-Lipophosphonoxins: A Novel Approach in Designing Membrane Targeting Antimicrobials.
AID1242585	Antibacterial activity against methicillin-resistant Staphylococcus aureus R53 clinical isolate after 20 to 24 hrs by CLSI method	2015	ACS medicinal chemistry letters, Jul-09, Volume: 6, Issue:7	Triazole-Linked Glycolipids Enhance the Susceptibility of MRSA to β-Lactam Antibiotics.
AID509070	Induction of mecA gene expression in beta-lactamase positive SCCmec type 4a methicillin-resistant Staphylococcus aureus isolate 14154 at MIC after 1 hr by multiplex PCR method	2010	Antimicrobial agents and chemotherapy, Feb, Volume: 54, Issue:2	Effects of ceftobiprole and oxacillin on mecA expression in methicillin-resistant Staphylococcus aureus clinical isolates.
AID432812	Antimicrobial activity against SCCmec type 1 methicillin-resistant Staphylococcus aureus COL D19455-T2 expressing symporter gene smr1 at 42 degC incubated for 24 hrs by E-test	2008	Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2	Role of a sodium-dependent symporter homologue in the thermosensitivity of beta-lactam antibiotic resistance and cell wall composition in Staphylococcus aureus.
AID529114	Antimicrobial activity against methicillin-resistant Staphylococcus aureus HDE288 by Etest	2008	Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8	Comparative study of the susceptibilities of major epidemic clones of methicillin-resistant Staphylococcus aureus to oxacillin and to the new broad-spectrum cephalosporin ceftobiprole.
AID542618	Antimicrobial activity against streptomycin-resistant Streptococcus pneumoniae R6 harboring PBP2x T338G and PBP1a2349 mutant gene after 48 hrs by agar dilution method	2009	Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3	An important site in PBP2x of penicillin-resistant clinical isolates of Streptococcus pneumoniae: mutational analysis of Thr338.
AID519627	Antimicrobial activity against Brachyspira pilosicoli 80.10 without producing beta-lactamase OXA-63 by disc diffusion method	2008	Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4	Genetic and biochemical characterization of OXA-63, a new class D beta-lactamase from Brachyspira pilosicoli BM4442.
AID560500	Antimicrobial activity against SCCmec type II vancomycin-intermediate Staphylococcus aureus isolate sh06024 by agar dilution method	2009	Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9	Prevalence and characterization of heterogeneous vancomycin-intermediate Staphylococcus aureus isolates from 14 cities in China.
AID750317	Antibacterial activity against Staphylococcus aureus isolate C8 derived from naso-pharynx assessed as growth inhibition after 18 hrs by broth microdilution method	2013	European journal of medicinal chemistry, Jun, Volume: 64	Synthesis and evaluation of antimicrobial activity of hydrazones derived from 3-oxido-1H-imidazole-4-carbohydrazides.
AID422493	Antimicrobial activity against Carnobacterium divergens BM4490 expressing beta-lactamase CAD1 at 3 McFarland inoculum size by E-test	2008	Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2	Genetic and biochemical characterization of CAD-1, a chromosomally encoded new class A penicillinase from Carnobacterium divergens.
AID1601841	Antibacterial activity against Staphylococcus aureus CMCC(B) 26003 measured after 24 hrs by ELISA	2019	European journal of medicinal chemistry, Mar-15, Volume: 166	Synthesis, antimicrobial and cytotoxic activities, and molecular docking studies of N-arylsulfonylindoles containing an aminoguanidine, a semicarbazide, and a thiosemicarbazide moiety.
AID1870150	Antibacterial activity against wild type Staphylococcus aureus 4740/B assessed as reduction in microbial growth incubated for 24 hrs by microdilution assay	2022	Journal of medicinal chemistry, 07-28, Volume: 65, Issue:14	LEGO-Lipophosphonoxins: A Novel Approach in Designing Membrane Targeting Antimicrobials.
AID533121	Antimicrobial activity against methicillin-resistant Staphylococcus aureus N315DeltaIP heteroresistant subpopulations by Etest method	2008	Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12	Serial daptomycin selection generates daptomycin-nonsusceptible Staphylococcus aureus strains with a heterogeneous vancomycin-intermediate phenotype.
AID544614	Antibacterial activity against Staphylococcus aureus isolate 1552 infected in Wistar rat thigh infection model assessed as bacterial load per gram of thigh at 200 mg/kg, sc administered 2 hrs postinfection and every 6 hrs thereafter for 1 day measured aft	2008	Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11	In vitro and in vivo evaluations of oxacillin efficiency against mecA-positive oxacillin-susceptible Staphylococcus aureus.
AID402931	Antimicrobial activity against methicillin-resistant Staphylococcus aureus 12 after 24 hrs	2004	Journal of natural products, Jun, Volume: 67, Issue:6	New stilbene derivatives from Calligonum leucocladum.
AID1474167	Liver toxicity in human assessed as induction of drug-induced liver injury by measuring verified drug-induced liver injury concern status	2016	Drug discovery today, Apr, Volume: 21, Issue:4	DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
AID584996	Antibacterial activity against methicillin-resistant Staphylococcus aureus M05/0060 harboring cfr-encoding conjugative pSCFS7 and fexA by broth microdilution method	2010	Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12	Identification and characterization of the multidrug resistance gene cfr in a Panton-Valentine leukocidin-positive sequence type 8 methicillin-resistant Staphylococcus aureus IVa (USA300) isolate.
AID721791	Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC 33591 assessed as growth inhibition after 24 hrs by CLSI broth microdilution method	2013	European journal of medicinal chemistry, Feb, Volume: 60	Antimicrobial activity of various 4- and 5-substituted 1-phenylnaphthalenes.
AID542617	Antimicrobial activity against Streptococcus pneumoniae R6 harboring PBP2x2349 and PBP1a2349 mutant gene after 48 hrs by agar dilution method	2009	Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3	An important site in PBP2x of penicillin-resistant clinical isolates of Streptococcus pneumoniae: mutational analysis of Thr338.
AID565010	Antimicrobial activity against methicillin-susceptible coagulase-negative Staphylococcus haemolyticus assessed as resistant isolates after 24 hrs by broth microdilution method	2009	Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10	In vitro activities of panduratin A against clinical Staphylococcus strains.
AID509062	Antibacterial activity against beta-lactamase positive SCCmec type 2 methicillin-resistant Staphylococcus aureus isolate 17357 by broth microdilution method	2010	Antimicrobial agents and chemotherapy, Feb, Volume: 54, Issue:2	Effects of ceftobiprole and oxacillin on mecA expression in methicillin-resistant Staphylococcus aureus clinical isolates.
AID245084	Minimum inhibitory concentration against methicillin resistant Staphylococcus aureus strain EMRSA 15	2005	Bioorganic & medicinal chemistry letters, May-16, Volume: 15, Issue:10	Synthesis and antibacterial activity of hydrolytically stable (-)-epicatechin gallate analogues for the modulation of beta-lactam resistance in Staphylococcus aureus.
AID1209735	Inhibition of mouse OAT3 expressed in CHO cells assessed as inhibition of fluorescein uptake at 500 uM over 20 mins relative to untreated-control	2013	Drug metabolism and disposition: the biological fate of chemicals, Apr, Volume: 41, Issue:4	Organic anion transporter 3 interacts selectively with lipophilic β-lactam antibiotics.
AID1242573	Downregulation of mecA mRNA expression in methicillin-resistant Staphylococcus aureus ATCC 43300 at 2 ug/ml after 4 hrs by RT-PCR analysis	2015	ACS medicinal chemistry letters, Jul-09, Volume: 6, Issue:7	Triazole-Linked Glycolipids Enhance the Susceptibility of MRSA to β-Lactam Antibiotics.
AID1601843	Antibacterial activity against Streptococcus pyogenes CMCC 32067 measured after 24 hrs by ELISA	2019	European journal of medicinal chemistry, Mar-15, Volume: 166	Synthesis, antimicrobial and cytotoxic activities, and molecular docking studies of N-arylsulfonylindoles containing an aminoguanidine, a semicarbazide, and a thiosemicarbazide moiety.
AID1324844	Antimicrobial activity against Staphylococcus aureus ATCC 43300 by CLSI M07-A9 method	2016	Journal of natural products, 07-22, Volume: 79, Issue:7	Polybrominated Diphenyl Ethers: Structure Determination and Trends in Antibacterial Activity.
AID1209734	Inhibition of mouse OAT1 expressed in CHO cells assessed as inhibition of fluorescein uptake at 500 uM over 20 mins relative to untreated-control	2013	Drug metabolism and disposition: the biological fate of chemicals, Apr, Volume: 41, Issue:4	Organic anion transporter 3 interacts selectively with lipophilic β-lactam antibiotics.
AID529554	Antimicrobial activity against Bacillus anthracis MurA1 AS clone 2G2 assessed as growth inhibition in presence of xylose by antisense-induced hypersensitive testing	2008	Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6	Comparison of the essential cellular functions of the two murA genes of Bacillus anthracis.
AID520723	Activity of Acinetobacter baumannii phenotype 1 beta-lactamase assessed per mg of protein at 100 uM	2008	Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5	Carbapenem-resistant Acinetobacter baumannii isolates from Tunisia producing the OXA-58-like carbapenem-hydrolyzing oxacillinase OXA-97.
AID1079931	Moderate liver toxicity, defined via clinical-chemistry results: ALT or AST serum activity 6 times the normal upper limit (N) or alkaline phosphatase serum activity of 1.7 N. Value is number of references indexed. [column 'BIOL' in source]
AID528533	Antimicrobial activity against penicillin-resistant Streptococcus agalactiae B502 by agar dilution method	2008	Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8	First molecular characterization of group B streptococci with reduced penicillin susceptibility.
AID475622	Antimicrobial activity against vancomycin-resistant Enterococcus faecium isolate 14	2010	Bioorganic & medicinal chemistry letters, Apr-01, Volume: 20, Issue:7	7-Phenylplatensimycin and 11-methyl-7-phenylplatensimycin: more potent analogs of platensimycin.
AID548126	Antibacterial activity against Staphylococcus aureus RN 4220 after 20 hrs by twofold serial dilution technique	2010	European journal of medicinal chemistry, Dec, Volume: 45, Issue:12	Synthesis of new chalcone derivatives containing a rhodanine-3-acetic acid moiety with potential anti-bacterial activity.
AID556044	Antimicrobial activity against glycopepeptide-intermediate-resistant Staphylococcus aureus NCTC 8325 by broth microdilution method	2009	Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5	Functional characterization of the sigmaB-dependent yabJ-spoVG operon in Staphylococcus aureus: role in methicillin and glycopeptide resistance.
AID1055335	Antibacterial activity against vancomycin-sensitive Enterococcus faecalis 09-8 assessed as growth inhibition after 18 hrs by agar dilution method	2013	Journal of natural products, Nov-22, Volume: 76, Issue:11	Identification of elaiophylin derivatives from the marine-derived actinomycete Streptomyces sp. 7-145 using PCR-based screening.
AID560499	Antimicrobial activity against SCCmec type III vancomycin-intermediate Staphylococcus aureus isolate 5zjsau3 by agar dilution method	2009	Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9	Prevalence and characterization of heterogeneous vancomycin-intermediate Staphylococcus aureus isolates from 14 cities in China.
AID1601849	Antibacterial activity against Pseudomonas aeruginosa CMCC 27853 measured after 24 hrs by ELISA	2019	European journal of medicinal chemistry, Mar-15, Volume: 166	Synthesis, antimicrobial and cytotoxic activities, and molecular docking studies of N-arylsulfonylindoles containing an aminoguanidine, a semicarbazide, and a thiosemicarbazide moiety.
AID584482	Antibacterial activity against mecA-negative Staphylococcus vitulinus SVMN12 by agar dilution method	2010	Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10	Origin and molecular evolution of the determinant of methicillin resistance in staphylococci.
AID524394	Antibacterial activity against Escherichia coli NKE1355 harboring deletion mutation in acrB protein and plasmid expressing BAD gene in presence of increasing concentration of arabinose	2010	Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5	Effect of NlpE overproduction on multidrug resistance in Escherichia coli.
AID556042	Antimicrobial activity against erythromycin-resistant, tetracycline-sensitive and yabJ-spoVG operon deficient Staphylococcus aureus COL mutant by broth microdilution method	2009	Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5	Functional characterization of the sigmaB-dependent yabJ-spoVG operon in Staphylococcus aureus: role in methicillin and glycopeptide resistance.
AID545962	Antimicrobial activity against methicillin-resistant Staphylococcus aureus 16686 by broth dilution method	2010	Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8	Identification of a novel transposon (Tn6072) and a truncated staphylococcal cassette chromosome mec element in methicillin-resistant Staphylococcus aureus ST239.
AID567454	Antimicrobial activity against methicillin-resistant Staphylococcus aureus CGK6 by Etest method	2010	Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9	Development of daptomycin nonsusceptibility with heterogeneous vancomycin-intermediate resistance and oxacillin susceptibility in methicillin-resistant Staphylococcus aureus during high-dose daptomycin treatment.
AID1079938	Chronic liver disease either proven histopathologically, or through a chonic elevation of serum amino-transferase activity after 6 months. Value is number of references indexed. [column 'CHRON' in source]
AID278673	Antibacterial activity against vancomycin-resistant Staphylococcus aureus isolate 5734	2007	Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1	High-level vancomycin-resistant Staphylococcus aureus isolates associated with a polymicrobial biofilm.
AID1818974	Antibacterial activity against Escherichia coli ATCC 12701 assessed as bacterial clearance incubated for 6 to 24 hrs by microbroth dilution method	2022	Journal of medicinal chemistry, 01-13, Volume: 65, Issue:1	Discovery of
AID558779	Antibacterial activity against tolC-deficient Salmonella enterica NKS419 harboring hns gene by CLSI method	2009	Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8	H-NS modulates multidrug resistance of Salmonella enterica serovar Typhimurium by repressing multidrug efflux genes acrEF.
AID1517064	Antibacterial activity against Staphylococcus aureus ATCC 25923 assessed as reduction in bacterial growth incubated for 24 hrs by serial dilution method	2019	European journal of medicinal chemistry, Dec-01, Volume: 183	Two optimized antimicrobial peptides with therapeutic potential for clinical antibiotic-resistant Staphylococcus aureus.
AID1294717	Bactericidal activity against methicillin-resistant Staphylococcus aureus isolate 1a assessed as reduction in colony counts at 32 ug/ml after 12 hrs by pour plate method (Rvb = 10.12 +/- 0.428 log10CFU/ml)	2016	European journal of medicinal chemistry, Jun-10, Volume: 115	Anti-methicillin resistant Staphylococcus aureus activity, synergism with oxacillin and molecular docking studies of metronidazole-triazole hybrids.
AID761549	Antibacterial activity against Klebsiella aerogenes (SHV-1) 1976E by M07-A9 CLSI method	2013	Bioorganic & medicinal chemistry letters, Aug-01, Volume: 23, Issue:15	Synthesis and antimicrobial activity of imidazole and pyridine appended cholestane-based conjugates.
AID1438618	Antibacterial activity against methicillin-resistant Staphylococcus aureus LAC USA300 after 18 hrs by broth microdilution assay	2017	European journal of medicinal chemistry, Mar-10, Volume: 128	Synthesis, surfactant properties and antimicrobial activities of methyl glycopyranoside ethers.
AID609223	Antibacterial activity against 10'5 CFU/mL methicillin-resistant Staphylococcus aureus CCARM 3167 assessed as inhibition of bacterial growth after 24 hrs by microtiter enzyme-linked immunosorbent assay	2011	European journal of medicinal chemistry, Aug, Volume: 46, Issue:8	Synthesis of new chalcone derivatives bearing 2,4-thiazolidinedione and benzoic acid moieties as potential anti-bacterial agents.
AID542623	Antimicrobial activity against Streptococcus pneumoniae R6 harboring PBP2x T338P mutant gene, disruption at PBP1a and aad9 disruption in CiaR gene after 48 hrs by agar dilution method	2009	Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3	An important site in PBP2x of penicillin-resistant clinical isolates of Streptococcus pneumoniae: mutational analysis of Thr338.
AID340860	Antimicrobial activity against vancomycin-intermediate resistant Staphylococcus aureus Mu50 vraG mutant microdilution assay	2007	Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8	Interaction of the GraRS two-component system with the VraFG ABC transporter to support vancomycin-intermediate resistance in Staphylococcus aureus.
AID207780	Inhibition of growth of methicillin resistant Staphylococcus aureus MRSA OC 2089.	2001	Bioorganic & medicinal chemistry letters, Jun-18, Volume: 11, Issue:12	Amidino benzimidazole inhibitors of bacterial two-component systems.
AID1294676	Antimicrobial activity against methicillin-resistant Staphylococcus aureus isolate 22a after 24 hrs by agar plate dilution method	2016	European journal of medicinal chemistry, Jun-10, Volume: 115	Anti-methicillin resistant Staphylococcus aureus activity, synergism with oxacillin and molecular docking studies of metronidazole-triazole hybrids.
AID575147	Antimicrobial activity against vancomycin-resistant Staphylococcus aureus VRS1 by broth microdilution method	2010	Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9	Inhibition of antibiotic-resistant Staphylococcus aureus by the broad-spectrum dihydrofolate reductase inhibitor RAB1.
AID432982	Antimicrobial activity against SCCmec type 1 methicillin-resistant Staphylococcus aureus COL 404 expressing symporter gene smr1 at 42 degC incubated for 24 hrs by E-test	2008	Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2	Role of a sodium-dependent symporter homologue in the thermosensitivity of beta-lactam antibiotic resistance and cell wall composition in Staphylococcus aureus.
AID340888	Antimicrobial activity against Escherichia coli JM83 harboring pACYC184-TEM by serial dilution method	2007	Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8	Cytoplasmic-membrane anchoring of a class A beta-lactamase and its capacity in manifesting antibiotic resistance.
AID1567125	Antimicrobial activity against Staphylococcus epidermidis ATCC 12228 incubated for 20 hrs by microdilution method	2019	European journal of medicinal chemistry, Sep-15, Volume: 178	Design, synthesis and biological evaluation of antimicrobial diarylimine and -amine compounds targeting the interaction between the bacterial NusB and NusE proteins.
AID1870156	Antibacterial activity against wild type Staphylococcus aureus 4515/A assessed as reduction in microbial growth incubated for 24 hrs by microdilution assay	2022	Journal of medicinal chemistry, 07-28, Volume: 65, Issue:14	LEGO-Lipophosphonoxins: A Novel Approach in Designing Membrane Targeting Antimicrobials.
AID1517078	Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC 19900 assessed as reduction in bacterial growth incubated for 24 hrs by serial dilution method	2019	European journal of medicinal chemistry, Dec-01, Volume: 183	Two optimized antimicrobial peptides with therapeutic potential for clinical antibiotic-resistant Staphylococcus aureus.
AID521076	Antibacterial activity against group 4-v3 PVL negative community-acquired methicillin-resistant Staphylococcus aureus ST 59 expressing SCCmec type IVc gene by agar dilution method	2008	Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3	Novel characteristics of community-acquired methicillin-resistant Staphylococcus aureus strains belonging to multilocus sequence type 59 in Taiwan.
AID1438623	Antibacterial activity against methicillin-resistant Staphylococcus aureus isolate HT 2006-1004 after 18 hrs by broth microdilution assay	2017	European journal of medicinal chemistry, Mar-10, Volume: 128	Synthesis, surfactant properties and antimicrobial activities of methyl glycopyranoside ethers.
AID1079935	Cytolytic liver toxicity, either proven histopathologically or where the ratio of maximal ALT or AST activity above normal to that of Alkaline Phosphatase is > 5 (see ACUTE). Value is number of references indexed. [column 'CYTOL' in source]
AID1639001	Antibacterial activity against Enterococcus faecium ATCC BAA-6569 after 24 hrs by resazurin dye based fluorescence assay	2019	Journal of natural products, 04-26, Volume: 82, Issue:4	Mindapyrroles A-C, Pyoluteorin Analogues from a Shipworm-Associated Bacterium.
AID584471	Antibacterial activity against mecA-negative Staphylococcus vitulinus SVMN01 (ATCC 51145T) by agar dilution method	2010	Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10	Origin and molecular evolution of the determinant of methicillin resistance in staphylococci.
AID1870144	Antibacterial activity against wild type Staphylococcus aureus 4883/C assessed as reduction in microbial growth incubated for 24 hrs by microdilution assay	2022	Journal of medicinal chemistry, 07-28, Volume: 65, Issue:14	LEGO-Lipophosphonoxins: A Novel Approach in Designing Membrane Targeting Antimicrobials.
AID524388	Antibacterial activity against Escherichia coli NKE1366 harboring deletion mutation in acrB and vector expressing mdtABC gene	2010	Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5	Effect of NlpE overproduction on multidrug resistance in Escherichia coli.
AID405598	Increase in proline dehydrogenase homolog gene expression in oxacillin-dependent methicillin-resistant Staphylococcus aureus 2884D isolate at 0.5 ug/ml by microarray-based transcriptional profiling relative to control	2007	Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7	Identification and phenotypic characterization of a beta-lactam-dependent, methicillin-resistant Staphylococcus aureus strain.
AID509069	Induction of mecA gene expression in beta-lactamase positive SCCmec type 4a methicillin-resistant Staphylococcus aureus isolate 14145 at MIC after 1 hr by multiplex PCR method	2010	Antimicrobial agents and chemotherapy, Feb, Volume: 54, Issue:2	Effects of ceftobiprole and oxacillin on mecA expression in methicillin-resistant Staphylococcus aureus clinical isolates.
AID574552	Decrease in delta toxin levels in Staphylococcus aureus USA300 at subinhibitory concentrations after 24 hrs by RP-HPLC/ESI- MS	2010	Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11	Subinhibitory concentrations of protein synthesis-inhibiting antibiotics promote increased expression of the agr virulence regulator and production of phenol-soluble modulin cytolysins in community-associated methicillin-resistant Staphylococcus aureus.
AID325443	Antibacterial activity against Escherichia coli K10 after 14 to 16 hrs by broth dilution method	2007	Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6	Polyamine effects on antibiotic susceptibility in bacteria.
AID1651733	Antibacterial activity against Methicillin-resistant Staphylococcus hominis MB124 after 24 hrs by microdilution assay	2020	Journal of natural products, 04-24, Volume: 83, Issue:4	Antibacterial and ATP Synthesis Modulating Compounds from
AID544597	Effect on growth of Staphylococcus aureus isolate 1306 assessed as highest compound concentration at which cell growth occurred measured after 48 hrs	2008	Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11	In vitro and in vivo evaluations of oxacillin efficiency against mecA-positive oxacillin-susceptible Staphylococcus aureus.
AID534155	Antimicrobial activity against linezolid-resistant Enterococcus faecalis 3128 harboring G2576U mutation in peptidyl transferase centre by broth microdilution method	2008	Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12	In vitro activity of TR-700, the antibacterial moiety of the prodrug TR-701, against linezolid-resistant strains.
AID545956	Antimicrobial activity against methicillin-resistant Staphylococcus aureus 16666 by broth dilution method	2010	Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8	Identification of a novel transposon (Tn6072) and a truncated staphylococcal cassette chromosome mec element in methicillin-resistant Staphylococcus aureus ST239.
AID750312	Antibacterial activity against Staphylococcus aureus isolate F12 derived from ulcer and furuncle assessed as growth inhibition after 18 hrs by broth microdilution method	2013	European journal of medicinal chemistry, Jun, Volume: 64	Synthesis and evaluation of antimicrobial activity of hydrazones derived from 3-oxido-1H-imidazole-4-carbohydrazides.
AID1567129	Antimicrobial activity against Staphylococcus aureus ST239 incubated for 20 hrs by microdilution method	2019	European journal of medicinal chemistry, Sep-15, Volume: 178	Design, synthesis and biological evaluation of antimicrobial diarylimine and -amine compounds targeting the interaction between the bacterial NusB and NusE proteins.
AID1853619	Antibacterial activity against Staphylococcus aureus clinical isolate 1089106 assessed as inhibition of bacterial growth by CLSI protocol based broth microdilution method	2021	RSC medicinal chemistry, Oct-20, Volume: 12, Issue:10	Design, synthesis, and antibacterial activity of
AID421761	Antibacterial activity against tetracycline-effluxing Staphylococcus aureus XU212 after 72 hrs	2009	Journal of natural products, Mar-27, Volume: 72, Issue:3	Bioactive pyridine-N-oxide disulfides from Allium stipitatum.
AID1517080	Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC 19423 assessed as reduction in bacterial growth incubated for 24 hrs by serial dilution method	2019	European journal of medicinal chemistry, Dec-01, Volume: 183	Two optimized antimicrobial peptides with therapeutic potential for clinical antibiotic-resistant Staphylococcus aureus.
AID1827262	Upregulation of mecA gene expression in methicillin-resistant Staphylococcus aureus USA300 by RT-PCR method	2022	ACS medicinal chemistry letters, Mar-10, Volume: 13, Issue:3	Identification and Evaluation of Brominated Carbazoles as a Novel Antibiotic Adjuvant Scaffold in MRSA.
AID1567135	Antimicrobial activity against Staphylococcus aureus USA300/ST8 incubated for 20 hrs by microdilution method	2019	European journal of medicinal chemistry, Sep-15, Volume: 178	Design, synthesis and biological evaluation of antimicrobial diarylimine and -amine compounds targeting the interaction between the bacterial NusB and NusE proteins.
AID530768	Induction of PsgtB::lacZ gene expression in Staphylococcus aureus SH1000 at 8 ug/ml after 2 hrs by beta-galactosidase reporter gene assay relative to untreated control	2008	Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8	Staphylococcus aureus cell wall stress stimulon gene-lacZ fusion strains: potential for use in screening for cell wall-active antimicrobials.
AID1759648	Antimicrobial activity against vancomycin-resistant Enterococcus faecium clinical isolate 1089544 by CLSI-based broth microdilution assay	2021	European journal of medicinal chemistry, Jul-05, Volume: 219	4-4-(Anilinomethyl)-3-[4-(trifluoromethyl)phenyl]-1H-pyrazol-1-ylbenzoic acid derivatives as potent anti-gram-positive bacterial agents.
AID1763159	Antibacterial activity against methicillin-resistant Staphylococcus aureus 59 assessed as reduction in bacterial growth incubated for 24 hrs by CLSI based serial dilution method	2021	Bioorganic & medicinal chemistry, 05-15, Volume: 38	Antibacterial and synergistic activity of 6β-hydroxy-3-oxolup-20(29)-en-28-oic acid (6β-hydroxy betunolic acid) isolated from Schumacheria castaneifolia vahl.
AID726490	Antibacterial activity against quinolone-resistant Staphylococcus aureus CCARM 3519 assessed as bacterial growth inhibition measured during 24 hrs incubation at 37 degC by two-fold serial dilution technique	2013	European journal of medicinal chemistry, Feb, Volume: 60	Synthesis and antibacterial evaluation of rhodanine-based 5-aryloxy pyrazoles against selected methicillin resistant and quinolone-resistant Staphylococcus aureus (MRSA and QRSA).
AID520727	Activity of Escherichia coli TOP10 beta-lactamase OXA-97 assessed as specific activity per mg of protein at 100 uM	2008	Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5	Carbapenem-resistant Acinetobacter baumannii isolates from Tunisia producing the OXA-58-like carbapenem-hydrolyzing oxacillinase OXA-97.
AID432966	Antimicrobial activity against SCCmec type 1 methicillin-resistant Staphylococcus aureus COL E3005 expressing symporter gene smr1 at 42 degC incubated for 24 hrs by E-test	2008	Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2	Role of a sodium-dependent symporter homologue in the thermosensitivity of beta-lactam antibiotic resistance and cell wall composition in Staphylococcus aureus.
AID67218	Compound was tested for its antibacterial activity against Enterococcus faecalis OC 3041.	1998	Bioorganic & medicinal chemistry letters, Jul-21, Volume: 8, Issue:14	Novel inhibitors of bacterial two-component systems with gram positive antibacterial activity: pharmacophore identification based on the screening hit closantel.
AID560508	Antimicrobial activity against SCCmec type III vancomycin-intermediate Staphylococcus aureus isolate b3k5923 by agar dilution method	2009	Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9	Prevalence and characterization of heterogeneous vancomycin-intermediate Staphylococcus aureus isolates from 14 cities in China.
AID750334	Bactericidal activity against Staphylococcus aureus ATCC 29213 after 18 hrs by broth microdilution method	2013	European journal of medicinal chemistry, Jun, Volume: 64	Synthesis and evaluation of antimicrobial activity of hydrazones derived from 3-oxido-1H-imidazole-4-carbohydrazides.
AID558778	Antibacterial activity against tolC-deficient Salmonella enterica NKS174 by CLSI method	2009	Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8	H-NS modulates multidrug resistance of Salmonella enterica serovar Typhimurium by repressing multidrug efflux genes acrEF.
AID528495	Antimicrobial activity against high level levofloxacin and methicillin-resistant Staphylococcus aureus JCSC 6764 expressing gyrA Ser84Leu, gyrB Asp437Glu norA T389C and grlA Ser80Phe/Glu84Lys mutants by broth microdilution method	2008	Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8	Postantibiotic effects and bactericidal activities of levofloxacin and gatifloxacin at concentrations simulating those of topical ophthalmic administration against fluoroquinolone-resistant and fluoroquinolone-sensitive methicillin-resistant Staphylococcu
AID1517072	Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC 18878 assessed as reduction in bacterial growth incubated for 24 hrs by serial dilution method	2019	European journal of medicinal chemistry, Dec-01, Volume: 183	Two optimized antimicrobial peptides with therapeutic potential for clinical antibiotic-resistant Staphylococcus aureus.
AID1895487	Antibacterial activity against methicillin resistant Staphylococcus aureus incubated for 24 hrs by broth microdilution method	2021	European journal of medicinal chemistry, Nov-15, Volume: 224	Synthetic access to thiolane-based therapeutics and biological activity studies.
AID521073	Antibacterial activity against group 4 PVL negative community-acquired methicillin-resistant Staphylococcus aureus ST 59 expressing SCCmec type IVx gene by agar dilution method	2008	Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3	Novel characteristics of community-acquired methicillin-resistant Staphylococcus aureus strains belonging to multilocus sequence type 59 in Taiwan.
AID1737454	Antibacterial activity against methicillin susceptible Staphylococcus aureus ATCC 29213 after 16 to 18 hrs by CLSI-based microbroth dilution method	2020	European journal of medicinal chemistry, Jun-01, Volume: 195	Synthesis of novel monocarbonyl curcuminoids, evaluation of their efficacy against MRSA, including ex vivo infection model and their mechanistic studies.
AID562602	Antimicrobial activity against Staphylococcus epidermidis clinical isolates assessed as resistant isolates by broth microdilution method	2009	Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11	Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates.
AID1254077	Antibacterial activity against methicillin-resistant Staphylococcus aureus CCARM 3167 after 24 hrs by two-fold serial dilution method	2015	Bioorganic & medicinal chemistry letters, Nov-15, Volume: 25, Issue:22	Synthesis and biological evaluation of 1,3-diaryl pyrazole derivatives as potential antibacterial and anti-inflammatory agents.
AID432967	Antimicrobial activity against SCCmec type 1 methicillin-resistant Staphylococcus aureus COL E3005-T4 expressing symporter gene smr1 at 37 degC incubated for 24 hrs by E-test	2008	Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2	Role of a sodium-dependent symporter homologue in the thermosensitivity of beta-lactam antibiotic resistance and cell wall composition in Staphylococcus aureus.
AID1242591	Antibacterial activity against methicillin-resistant Staphylococcus aureus R314 clinical isolate after 20 to 24 hrs by CLSI method	2015	ACS medicinal chemistry letters, Jul-09, Volume: 6, Issue:7	Triazole-Linked Glycolipids Enhance the Susceptibility of MRSA to β-Lactam Antibiotics.
AID1869528	Antibacterial activity against Bacillus subtilis ATCC6633 measured after 24 hrs by broth microdilution method
AID543951	Antibacterial activity against oxacillin, chloramphenicol, erythromycin-susceptible and tetracycline-resistant Staphylococcus aureus COL-S with SCCmec excised	2009	Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2	Reconstruction of the phenotypes of methicillin-resistant Staphylococcus aureus by replacement of the staphylococcal cassette chromosome mec with a plasmid-borne copy of Staphylococcus sciuri pbpD gene.
AID402925	Antimicrobial activity against methicillin-resistant Staphylococcus aureus 4 after 24 hrs	2004	Journal of natural products, Jun, Volume: 67, Issue:6	New stilbene derivatives from Calligonum leucocladum.
AID278908	Antibacterial activity against methicillin-resistant Staphylococcus aureus	2007	Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1	In vitro antibacterial activity of the pyrrolopyrazolyl-substituted oxazolidinone RWJ-416457.
AID1079939	Cirrhosis, proven histopathologically. Value is number of references indexed. [column 'CIRRH' in source]
AID1634707	Antibacterial activity against vancomycin/methicillin-sensitive Staphylococcus aureus ATCC 25923 assessed as bacterial growth inhibition after 24 hrs by broth dilution method	2016	Journal of natural products, Apr-22, Volume: 79, Issue:4	Domino Synthesis of Embelin Derivatives with Antibacterial Activity.
AID508838	Induction of mecA gene expression in beta-lactamase positive SCCmec type 3 methicillin-resistant Staphylococcus aureus isolate 14567 at MIC after 1 hr by multiplex PCR method	2010	Antimicrobial agents and chemotherapy, Feb, Volume: 54, Issue:2	Effects of ceftobiprole and oxacillin on mecA expression in methicillin-resistant Staphylococcus aureus clinical isolates.
AID573124	Antibacterial activity against coagulase-negative and oxacillin-resistant Staphylococcus aureus assessed as resistant isolates by CLSI M7-A7 broth microdilution method	2008	Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9	In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States.
AID529136	Antimicrobial activity against methicillin-resistant Staphylococcus aureus HAR24 assessed as concentration required for minimum inhibition of oxacillin-resistant subpopulation growth by Etest	2008	Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8	Comparative study of the susceptibilities of major epidemic clones of methicillin-resistant Staphylococcus aureus to oxacillin and to the new broad-spectrum cephalosporin ceftobiprole.
AID1691362	Antimicrobial activity against multidrug-resistant Pseudomonas aeruginosa CCARM 2109 assessed as reduction in microbial growth incubated for 18 to 24 hrs by broth microdilution method	2020	European journal of medicinal chemistry, May-01, Volume: 193	Antibacterial AZT derivative regulates metastasis of breast cancer cells.
AID1246257	Antimicrobial activity against methicillin-resistant Staphylococcus aureus HEMSA incubated for 20 hrs by serial dilution broth microplate method	2015	European journal of medicinal chemistry, Aug-28, Volume: 101	Imidazolidine-4-one derivatives in the search for novel chemosensitizers of Staphylococcus aureus MRSA: synthesis, biological evaluation and molecular modeling studies.
AID558777	Antibacterial activity against acrB-deficient Salmonella enterica NKS291 harboring hns gene by CLSI method	2009	Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8	H-NS modulates multidrug resistance of Salmonella enterica serovar Typhimurium by repressing multidrug efflux genes acrEF.
AID1827254	Upregulation of blaZ gene expression in methicillin-resistant Staphylococcus aureus USA100 by RT-PCR method	2022	ACS medicinal chemistry letters, Mar-10, Volume: 13, Issue:3	Identification and Evaluation of Brominated Carbazoles as a Novel Antibiotic Adjuvant Scaffold in MRSA.
AID528739	Antimicrobial activity against penicillin-resistant Streptococcus agalactiae B516 by agar dilution method	2008	Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8	First molecular characterization of group B streptococci with reduced penicillin susceptibility.
AID325444	Antibacterial activity against Escherichia coli K12 after 14 to 16 hrs by broth dilution method	2007	Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6	Polyamine effects on antibiotic susceptibility in bacteria.
AID475609	Antimicrobial activity against methicillin-sensitive Staphylococcus aureus isolate 1	2010	Bioorganic & medicinal chemistry letters, Apr-01, Volume: 20, Issue:7	7-Phenylplatensimycin and 11-methyl-7-phenylplatensimycin: more potent analogs of platensimycin.
AID544595	Antibacterial activity against Staphylococcus aureus isolate 2712 by agar dilution method	2008	Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11	In vitro and in vivo evaluations of oxacillin efficiency against mecA-positive oxacillin-susceptible Staphylococcus aureus.
AID29359	Ionization constant (pKa)	2000	Journal of medicinal chemistry, Jun-29, Volume: 43, Issue:13	QSAR model for drug human oral bioavailability.
AID1870151	Antibacterial activity against wild type Staphylococcus aureus 4717/B assessed as reduction in microbial growth incubated for 24 hrs by microdilution assay	2022	Journal of medicinal chemistry, 07-28, Volume: 65, Issue:14	LEGO-Lipophosphonoxins: A Novel Approach in Designing Membrane Targeting Antimicrobials.
AID545968	Antimicrobial activity against methicillin-resistant Staphylococcus aureus 16704 by broth dilution method	2010	Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8	Identification of a novel transposon (Tn6072) and a truncated staphylococcal cassette chromosome mec element in methicillin-resistant Staphylococcus aureus ST239.
AID629347	Antifungal activity against Candida tenuis assessed as zone of inhibition at 0.01 mg/mL after 48 to 72 hrs by stiff-plate agar-diffusion method	2011	European journal of medicinal chemistry, Dec, Volume: 46, Issue:12	Synthesis and biological activity of novel N-cycloalkyl-(cycloalkylaryl)-2-[(3-R-2-oxo-2H-[1,2,4]triazino[2,3-c]quinazoline-6-yl)thio]acetamides.
AID432811	Antimicrobial activity against SCCmec type 1 methicillin-resistant Staphylococcus aureus COL D19455-T2 expressing symporter gene smr1 at 37 degC incubated for 24 hrs by E-test	2008	Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2	Role of a sodium-dependent symporter homologue in the thermosensitivity of beta-lactam antibiotic resistance and cell wall composition in Staphylococcus aureus.
AID520872	Antibacterial activity against methicillin-resistant mecA-positive Staphylococcus saprophyticus isolate TSU67 isolated from genitourinary tracts of acute cystitis patient after 24 hrs at 35 degC by agar dilution method	2008	Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6	Methicillin-resistant Staphylococcus saprophyticus isolates carrying staphylococcal cassette chromosome mec have emerged in urogenital tract infections.
AID544589	Antibacterial activity against Staphylococcus aureus isolate 1306 infected in Wistar rat thigh infection model assessed as bacterial load per gram of thigh at 200 mg/kg, sc administered 2 hrs postinfection and every 6 hrs thereafter for 1 day measured aft	2008	Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11	In vitro and in vivo evaluations of oxacillin efficiency against mecA-positive oxacillin-susceptible Staphylococcus aureus.
AID1759654	Antimicrobial activity against against methicillin-resistant Staphylococcus aureus clinical isolate 1088064 by CLSI-based broth microdilution assay	2021	European journal of medicinal chemistry, Jul-05, Volume: 219	4-4-(Anilinomethyl)-3-[4-(trifluoromethyl)phenyl]-1H-pyrazol-1-ylbenzoic acid derivatives as potent anti-gram-positive bacterial agents.
AID405599	Increase in cold shock protein gene expression in oxacillin-dependent methicillin-resistant Staphylococcus aureus 2884D isolate at 0.5 ug/ml by microarray-based transcriptional profiling relative to control	2007	Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7	Identification and phenotypic characterization of a beta-lactam-dependent, methicillin-resistant Staphylococcus aureus strain.
AID475612	Antimicrobial activity against methicillin-sensitive Staphylococcus aureus isolate 4	2010	Bioorganic & medicinal chemistry letters, Apr-01, Volume: 20, Issue:7	7-Phenylplatensimycin and 11-methyl-7-phenylplatensimycin: more potent analogs of platensimycin.
AID509055	Antibacterial activity against beta-lactamase positive SCCmec type 1 methicillin-resistant Staphylococcus aureus isolate 12192 by broth microdilution method	2010	Antimicrobial agents and chemotherapy, Feb, Volume: 54, Issue:2	Effects of ceftobiprole and oxacillin on mecA expression in methicillin-resistant Staphylococcus aureus clinical isolates.
AID693708	Antibacterial activity against Escherichia coli CCARM 1356 after 20 hrs by two fold serial dilution assay	2012	European journal of medicinal chemistry, Dec, Volume: 58	Synthesis and antibacterial activity of novel 1,3-diphenyl-1H-pyrazoles functionalized with phenylalanine-derived rhodanines.
AID521071	Antibacterial activity against group 3 PVL negative community-acquired methicillin-resistant Staphylococcus aureus ST 239 expressing SCCmec type III gene by agar dilution method	2008	Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3	Novel characteristics of community-acquired methicillin-resistant Staphylococcus aureus strains belonging to multilocus sequence type 59 in Taiwan.
AID431094	Antibacterial activity against vancomycin-susceptible Staphylococcus aureus N315 harboring shuttle vector pYT3 after 24 hrs by agar dilution method	2008	Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1	Mutated response regulator graR is responsible for phenotypic conversion of Staphylococcus aureus from heterogeneous vancomycin-intermediate resistance to vancomycin-intermediate resistance.
AID581663	Antibacterial activity against Staphylococcus aureus SCV isolated from cystic fibrosis patient infected in human THP-1 cells assessed as log reduction of intracellular CFU level per mg of protein at up to 10'5 times MIC after 24 hrs	2009	Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4	Intracellular activity of antibiotics in a model of human THP-1 macrophages infected by a Staphylococcus aureus small-colony variant strain isolated from a cystic fibrosis patient: pharmacodynamic evaluation and comparison with isogenic normal-phenotype a
AID1759645	Antimicrobial activity against vancomycin-resistant Enterococcus faecium clinical isolate 1088168 by CLSI-based broth microdilution assay	2021	European journal of medicinal chemistry, Jul-05, Volume: 219	4-4-(Anilinomethyl)-3-[4-(trifluoromethyl)phenyl]-1H-pyrazol-1-ylbenzoic acid derivatives as potent anti-gram-positive bacterial agents.
AID205672	Compound was tested for its antibacterial activity against Staph aureus ATCC 29213.	1998	Bioorganic & medicinal chemistry letters, Jul-21, Volume: 8, Issue:14	Novel inhibitors of bacterial two-component systems with gram positive antibacterial activity: pharmacophore identification based on the screening hit closantel.
AID693705	Antibacterial activity against Staphylococcus aureus KCTC 503 after 20 hrs by two fold serial dilution assay	2012	European journal of medicinal chemistry, Dec, Volume: 58	Synthesis and antibacterial activity of novel 1,3-diphenyl-1H-pyrazoles functionalized with phenylalanine-derived rhodanines.
AID1242553	Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC 43300 assessed as growth inhibition at 2 ug/ml measured up to 24 hrs by time kill assay	2015	ACS medicinal chemistry letters, Jul-09, Volume: 6, Issue:7	Triazole-Linked Glycolipids Enhance the Susceptibility of MRSA to β-Lactam Antibiotics.
AID1254079	Antibacterial activity against quinolone-resistant Staphylococcus aureus CCARM 3505 after 24 hrs by two-fold serial dilution method	2015	Bioorganic & medicinal chemistry letters, Nov-15, Volume: 25, Issue:22	Synthesis and biological evaluation of 1,3-diaryl pyrazole derivatives as potential antibacterial and anti-inflammatory agents.
AID1294720	Bactericidal activity against methicillin-resistant Staphylococcus aureus isolate 1a assessed as reduction in colony counts at 32 ug/ml after 24 hrs by pour plate method (Rvb = 12.64 +/- 0.224 log10CFU/ml)	2016	European journal of medicinal chemistry, Jun-10, Volume: 115	Anti-methicillin resistant Staphylococcus aureus activity, synergism with oxacillin and molecular docking studies of metronidazole-triazole hybrids.
AID570780	Antimicrobial activity against wild type hospital-acquired methicillin-resistant Staphylococcus aureus 252 after 48 hrs by microdilution method	2008	Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11	Staphylococcus aureus PBP4 is essential for beta-lactam resistance in community-acquired methicillin-resistant strains.
AID524260	Antibacterial activity against Escherichia coli NKE96 harboring deletion mutation in acrB protein	2010	Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5	Effect of NlpE overproduction on multidrug resistance in Escherichia coli.
AID373187	Induction of VraSR-dependent tcaA gene expression in Staphylococcus aureus N315 at 10 ug/mL after 30 mins by Northern blot analysis	2007	Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11	Functional characterization of TcaA: minimal requirement for teicoplanin susceptibility and role in Caenorhabditis elegans virulence.
AID560513	Antimicrobial activity against SCCmec type III vancomycin-intermediate Staphylococcus aureus isolate b6k7974 by agar dilution method	2009	Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9	Prevalence and characterization of heterogeneous vancomycin-intermediate Staphylococcus aureus isolates from 14 cities in China.
AID558754	Antibacterial activity against methicillin-susceptible, tetracycline-resistant and chloramphenicol-resistant Staphylococcus aureus deltaIP-KVR by Etest method	2009	Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8	Selection of heterogeneous vancomycin-intermediate Staphylococcus aureus by imipenem.
AID584469	Antibacterial activity against methicillin-resistant mecA-positive Staphylococcus vitulinus SVMP05 by agar dilution method	2010	Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10	Origin and molecular evolution of the determinant of methicillin resistance in staphylococci.
AID1567115	Antimicrobial activity against Staphylococcus aureus ATCC 25923 incubated for 20 hrs by microdilution method	2019	European journal of medicinal chemistry, Sep-15, Volume: 178	Design, synthesis and biological evaluation of antimicrobial diarylimine and -amine compounds targeting the interaction between the bacterial NusB and NusE proteins.
AID567453	Antimicrobial activity against methicillin-resistant Staphylococcus aureus CGK5 by Etest method	2010	Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9	Development of daptomycin nonsusceptibility with heterogeneous vancomycin-intermediate resistance and oxacillin susceptibility in methicillin-resistant Staphylococcus aureus during high-dose daptomycin treatment.
AID718549	Antibacterial activity against Staphylococcus aureus KCTC 209 incubated for 24 hrs serial dilution method	2012	Bioorganic & medicinal chemistry letters, Dec-01, Volume: 22, Issue:23	Synthesis and biological evaluation of 5-aryloxypyrazole derivatives bearing a rhodanine-3-aromatic acid as potential antimicrobial agents.
AID528536	Antimicrobial activity against penicillin-resistant Streptococcus agalactiae B514 by agar dilution method	2008	Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8	First molecular characterization of group B streptococci with reduced penicillin susceptibility.
AID548253	Antibacterial activity against vancomycin-intermediate Staphylococcus aureus Mu50 after 24 hrs by Etest	2009	Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3	Contribution of vraSR and graSR point mutations to vancomycin resistance in vancomycin-intermediate Staphylococcus aureus.
AID1501385	Inhibition of cell wall biosynthesis in Bacillus subtilis assessed as induction of formation of misshapen cells at 1.875 ug/ml incubated for 2 hrs by FM-4-64 staining based assay	2017	European journal of medicinal chemistry, Oct-20, Volume: 139	Arylthiazole antibiotics targeting intracellular methicillin-resistant Staphylococcus aureus (MRSA) that interfere with bacterial cell wall synthesis.
AID432974	Antimicrobial activity against SCCmec type 3 methicillin-resistant Staphylococcus aureus COL 301 expressing symporter gene smr1 at 42 degC incubated for 24 hrs by E-test	2008	Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2	Role of a sodium-dependent symporter homologue in the thermosensitivity of beta-lactam antibiotic resistance and cell wall composition in Staphylococcus aureus.
AID1759650	Antimicrobial activity against methicillin-sensitive Staphylococcus aureus ATCC 29213 by CLSI-based broth microdilution assay	2021	European journal of medicinal chemistry, Jul-05, Volume: 219	4-4-(Anilinomethyl)-3-[4-(trifluoromethyl)phenyl]-1H-pyrazol-1-ylbenzoic acid derivatives as potent anti-gram-positive bacterial agents.
AID1501181	Antibacterial activity against Staphylococcus aureus ATCC 29213 by CLSI method	2017	Journal of natural products, 09-22, Volume: 80, Issue:9	Tulongicin, an Antibacterial Tri-Indole Alkaloid from a Deep-Water Topsentia sp. Sponge.
AID421762	Antibacterial activity against Staphylococcus aureus EMRSA15 after 72 hrs	2009	Journal of natural products, Mar-27, Volume: 72, Issue:3	Bioactive pyridine-N-oxide disulfides from Allium stipitatum.
AID1763156	Antibacterial activity against methicillin-resistant Staphylococcus aureus 114 assessed as reduction in bacterial growth incubated for 24 hrs by CLSI based serial dilution method	2021	Bioorganic & medicinal chemistry, 05-15, Volume: 38	Antibacterial and synergistic activity of 6β-hydroxy-3-oxolup-20(29)-en-28-oic acid (6β-hydroxy betunolic acid) isolated from Schumacheria castaneifolia vahl.
AID750339	Antibacterial activity against Staphylococcus epidermidis ATCC 12228 assessed as growth inhibition after 18 hrs by broth microdilution method	2013	European journal of medicinal chemistry, Jun, Volume: 64	Synthesis and evaluation of antimicrobial activity of hydrazones derived from 3-oxido-1H-imidazole-4-carbohydrazides.
AID1294660	Antimicrobial activity against methicillin-resistant Staphylococcus aureus isolate 6a after 24 hrs by agar plate dilution method	2016	European journal of medicinal chemistry, Jun-10, Volume: 115	Anti-methicillin resistant Staphylococcus aureus activity, synergism with oxacillin and molecular docking studies of metronidazole-triazole hybrids.
AID524384	Antibacterial activity against Escherichia coli NKE126 harboring deletion mutation in acrB and acrD protein	2010	Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5	Effect of NlpE overproduction on multidrug resistance in Escherichia coli.
AID475615	Antimicrobial activity against methicillin-resistant Staphylococcus aureus isolate 7	2010	Bioorganic & medicinal chemistry letters, Apr-01, Volume: 20, Issue:7	7-Phenylplatensimycin and 11-methyl-7-phenylplatensimycin: more potent analogs of platensimycin.
AID1067071	Antimicrobial activity against methicillin-resistant Staphylococcus aureus clinical isolate 3506 after 20 hrs by two-fold serial dilution technique	2014	European journal of medicinal chemistry, Mar-03, Volume: 74	Synthesis and evaluation of the antimicrobial activities of 3-((5-phenyl-1,3,4-oxadiazol-2-yl)methyl)-2-thioxothiazolidin-4-one derivatives.
AID564815	Antimicrobial activity against methicillin-resistant coagulase-negative Staphylococcus epidermidis assessed as susceptible isolates after 24 hrs by broth microdilution method	2009	Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10	In vitro activities of panduratin A against clinical Staphylococcus strains.
AID404947	Antibacterial activity against methicillin-resistant Staphylococcus aureus isolate assessed as percent resistant isolates by CLSI dilution method	2007	Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7	In vitro activities of CG400549, a novel FabI inhibitor, against recently isolated clinical staphylococcal strains in Korea.
AID431117	Antibacterial activity against mutated graR gene knockout heterogeneous vancomycin-intermediate Staphylococcus aureus Mu3 after 48 hrs by agar dilution method	2008	Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1	Mutated response regulator graR is responsible for phenotypic conversion of Staphylococcus aureus from heterogeneous vancomycin-intermediate resistance to vancomycin-intermediate resistance.
AID524392	Antibacterial activity against Escherichia coli NKE1369 harboring deletion mutation in acrB, acrD, mdtABC protein and plasmid expressing nlpE gene	2010	Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5	Effect of NlpE overproduction on multidrug resistance in Escherichia coli.
AID1294673	Antimicrobial activity against methicillin-resistant Staphylococcus aureus isolate 19a after 24 hrs by agar plate dilution method	2016	European journal of medicinal chemistry, Jun-10, Volume: 115	Anti-methicillin resistant Staphylococcus aureus activity, synergism with oxacillin and molecular docking studies of metronidazole-triazole hybrids.
AID529299	Displacement of benzyl-[14C]penicillin from Staphylococcus aureus PBP2a RU130 mutant at 2500 ug/ml by in vitro competitive assay	2008	Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8	Comparative study of the susceptibilities of major epidemic clones of methicillin-resistant Staphylococcus aureus to oxacillin and to the new broad-spectrum cephalosporin ceftobiprole.
AID424616	Antibacterial activity against Enterococcus avium AIS2007004 isolated from patients rectum by broth microdilution method	2008	Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2	Vancomycin-resistant Staphylococcus aureus isolates associated with Inc18-like vanA plasmids in Michigan.
AID325159	Antimicrobial activity against Escherichia coli	2007	Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6	Beta-lactam resistance in Haemophilus parasuis Is mediated by plasmid pB1000 bearing blaROB-1.
AID1651741	Antibacterial activity against Enterococcus avium MB119 after 24 hrs by microdilution assay	2020	Journal of natural products, 04-24, Volume: 83, Issue:4	Antibacterial and ATP Synthesis Modulating Compounds from
AID574290	Antimicrobial activity against community-acquired pbp3-deficient Staphylococcus aureus MW2 serotype USA400 by microdilution method	2008	Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11	Staphylococcus aureus PBP4 is essential for beta-lactam resistance in community-acquired methicillin-resistant strains.
AID285940	Antimicrobial activity against methicillin-susceptible Staphylococcus aureus ATCC 29213 in human monocyte-derived macrophages at 5 ug/ml assessed as bacterial viability after 4 hrs	2007	Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4	Antimicrobial activities of daptomycin, vancomycin, and oxacillin in human monocytes and of daptomycin in combination with gentamicin and/or rifampin in human monocytes and in broth against Staphylococcus aureus.
AID356958	Antibacterial activity against Staphylococcus aureus after 24 hrs by broth microdilution method	2002	Journal of natural products, Dec, Volume: 65, Issue:12	Antimicrobial activities of naphthazarins from Arnebia euchroma.
AID560501	Antimicrobial activity against SCCmec type III vancomycin-intermediate Staphylococcus aureus isolate gz06040 by agar dilution method	2009	Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9	Prevalence and characterization of heterogeneous vancomycin-intermediate Staphylococcus aureus isolates from 14 cities in China.
AID629344	Antibacterial activity against Escherichia coli assessed as zone of inhibition at 0.01 mg/mL after 24 hrs by stiff-plate agar-diffusion method	2011	European journal of medicinal chemistry, Dec, Volume: 46, Issue:12	Synthesis and biological activity of novel N-cycloalkyl-(cycloalkylaryl)-2-[(3-R-2-oxo-2H-[1,2,4]triazino[2,3-c]quinazoline-6-yl)thio]acetamides.
AID562598	Antimicrobial activity against oxacillin-susceptible Staphylococcus haemolyticus clinical isolates assessed as resistant isolates by broth microdilution method	2009	Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11	Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates.
AID574545	Antimicrobial activity against community-associated methicillin-resistant Staphylococcus aureus USA300	2010	Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11	Subinhibitory concentrations of protein synthesis-inhibiting antibiotics promote increased expression of the agr virulence regulator and production of phenol-soluble modulin cytolysins in community-associated methicillin-resistant Staphylococcus aureus.
AID1759640	Antimicrobial activity against vancomycin-resistant Enterococcus faecium clinical isolate 1088051 by CLSI-based broth microdilution assay	2021	European journal of medicinal chemistry, Jul-05, Volume: 219	4-4-(Anilinomethyl)-3-[4-(trifluoromethyl)phenyl]-1H-pyrazol-1-ylbenzoic acid derivatives as potent anti-gram-positive bacterial agents.
AID278664	Antibacterial activity against vancomycin-resistant Staphylococcus aureus isolate 595	2007	Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1	High-level vancomycin-resistant Staphylococcus aureus isolates associated with a polymicrobial biofilm.
AID1869526	Antibacterial activity against methicillin-resistant Staphylococcus aureus R6101 measured after 24 hrs by broth microdilution method
AID584293	Antibacterial activity against methicillin-resistant mecA-positive Staphylococcus fleurettii SFMP03 by agar dilution method	2010	Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10	Origin and molecular evolution of the determinant of methicillin resistance in staphylococci.
AID584476	Antibacterial activity against mecA-negative Staphylococcus vitulinus SVMN06 by agar dilution method	2010	Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10	Origin and molecular evolution of the determinant of methicillin resistance in staphylococci.
AID1869524	Antibacterial activity against methicillin-sensitive Staphylococcus aureus ATCC29213 measured after 24 hrs by broth microdilution method
AID509048	Antibacterial activity against beta-lactamase positive SCCmec type 4a methicillin-resistant Staphylococcus aureus isolate 12639 by broth microdilution method	2010	Antimicrobial agents and chemotherapy, Feb, Volume: 54, Issue:2	Effects of ceftobiprole and oxacillin on mecA expression in methicillin-resistant Staphylococcus aureus clinical isolates.
AID546185	Antimicrobial activity against methicillin-resistant Staphylococcus aureus 16708 by broth dilution method	2010	Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8	Identification of a novel transposon (Tn6072) and a truncated staphylococcal cassette chromosome mec element in methicillin-resistant Staphylococcus aureus ST239.
AID1567139	Antimicrobial activity against Staphylococcus aureus HA W235 ST5 incubated for 20 hrs by microdilution method	2019	European journal of medicinal chemistry, Sep-15, Volume: 178	Design, synthesis and biological evaluation of antimicrobial diarylimine and -amine compounds targeting the interaction between the bacterial NusB and NusE proteins.
AID475614	Antimicrobial activity against methicillin-resistant Staphylococcus aureus isolate 6	2010	Bioorganic & medicinal chemistry letters, Apr-01, Volume: 20, Issue:7	7-Phenylplatensimycin and 11-methyl-7-phenylplatensimycin: more potent analogs of platensimycin.
AID562394	Antimicrobial activity against oxacillin-susceptible Staphylococcus epidermidis clinical isolates assessed as percent susceptible isolates by broth microdilution method	2009	Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11	Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates.
AID546186	Antimicrobial activity against methicillin-resistant Staphylococcus aureus HDG2 by broth dilution method	2010	Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8	Identification of a novel transposon (Tn6072) and a truncated staphylococcal cassette chromosome mec element in methicillin-resistant Staphylococcus aureus ST239.
AID475618	Antimicrobial activity against vancomycin-insensitive Staphylococcus aureus isolate 10	2010	Bioorganic & medicinal chemistry letters, Apr-01, Volume: 20, Issue:7	7-Phenylplatensimycin and 11-methyl-7-phenylplatensimycin: more potent analogs of platensimycin.
AID574548	Increase in PSMalpha levels in Staphylococcus aureus Sanger 252 at subinhibitory concentrations after 24 hrs by RP-HPLC/ESI- MS	2010	Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11	Subinhibitory concentrations of protein synthesis-inhibiting antibiotics promote increased expression of the agr virulence regulator and production of phenol-soluble modulin cytolysins in community-associated methicillin-resistant Staphylococcus aureus.
AID285341	Antibacterial activity against community acquired methicillin-resistant Staphylococcus aureus HT20010734 in in Mueller-Hinton medium	2007	Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4	Effect of antibiotics on Staphylococcus aureus producing Panton-Valentine leukocidin.
AID583693	Antimicrobial activity against methicillin-resistant Staphylococcus aureus 10*3d1 harboring hypothetical protein SA1826 14A mutant and rpoB 621A mutant after 24 hrs by Etest method	2010	Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12	An RpoB mutation confers dual heteroresistance to daptomycin and vancomycin in Staphylococcus aureus.
AID325478	Antibacterial activity against Staphylococcus aureus N315 at 20 ug/ml after 12 hrs by time kill assay	2007	Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6	Polyamine effects on antibiotic susceptibility in bacteria.
AID667565	Antibacterial activity against quinolone-resistant Staphylococcus aureus CCARM 3519 after 24 hrs by two-fold serial dilution method	2012	European journal of medicinal chemistry, Aug, Volume: 54	Synthesis and bioactivity evaluation of rhodanine derivatives as potential anti-bacterial agents.
AID405612	Decrease in SAV1176 Mu50 gene expression in oxacillin-dependent methicillin-resistant Staphylococcus aureus 2884D isolate at 0.5 ug/ml by microarray-based transcriptional profiling relative to control	2007	Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7	Identification and phenotypic characterization of a beta-lactam-dependent, methicillin-resistant Staphylococcus aureus strain.
AID431113	Antibacterial activity against heterogeneous vancomycin-intermediate Staphylococcus aureus Mu3 harboring intact graR gene after 48 hrs by agar dilution method	2008	Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1	Mutated response regulator graR is responsible for phenotypic conversion of Staphylococcus aureus from heterogeneous vancomycin-intermediate resistance to vancomycin-intermediate resistance.
AID558756	Antibacterial activity against hetero-Methicillin-resistant and tetracycline-resistant and rifampicin-resistant Staphylococcus aureus deltaIP-rifR harboring RpoB H481Y mutant gene by Etest method	2009	Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8	Selection of heterogeneous vancomycin-intermediate Staphylococcus aureus by imipenem.
AID1638997	Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC 43300 after 24 hrs by resazurin dye based fluorescence assay	2019	Journal of natural products, 04-26, Volume: 82, Issue:4	Mindapyrroles A-C, Pyoluteorin Analogues from a Shipworm-Associated Bacterium.
AID1651728	Antibacterial activity against Methicillin-resistant Staphylococcus capitis MB71 after 24 hrs by microdilution assay	2020	Journal of natural products, 04-24, Volume: 83, Issue:4	Antibacterial and ATP Synthesis Modulating Compounds from
AID285919	Antimicrobial activity against methicillin-resistant Staphylococcus aureus ATCC 43300 in human monocyte-derived macrophages at 0.25 ug/ml assessed as bacterial viability after 4 hrs	2007	Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4	Antimicrobial activities of daptomycin, vancomycin, and oxacillin in human monocytes and of daptomycin in combination with gentamicin and/or rifampin in human monocytes and in broth against Staphylococcus aureus.
AID477409	Antibacterial activity against Staphylococcus aureus NCTC 8325 after 16 to 20 hrs by broth microdilution method	2010	Bioorganic & medicinal chemistry, Mar-15, Volume: 18, Issue:6	Efflux-mediated bis-indole resistance in Staphylococcus aureus reveals differential substrate specificities for MepA and MepR.
AID570774	Antimicrobial activity against community-acquired pbp3/4-deficient Staphylococcus aureus MW2 serotype USA400 by microdilution method relative to wild type	2008	Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11	Staphylococcus aureus PBP4 is essential for beta-lactam resistance in community-acquired methicillin-resistant strains.
AID1870138	Antibacterial activity against wild type methicillin resistant Staphylococcus aureus 4968/C assessed as reduction in microbial growth incubated for 24 hrs by microdilution assay	2022	Journal of medicinal chemistry, 07-28, Volume: 65, Issue:14	LEGO-Lipophosphonoxins: A Novel Approach in Designing Membrane Targeting Antimicrobials.
AID1567134	Antimicrobial activity against CA-methicillin-resistant Staphylococcus aureus W46 ST59 incubated for 20 hrs by microdilution method	2019	European journal of medicinal chemistry, Sep-15, Volume: 178	Design, synthesis and biological evaluation of antimicrobial diarylimine and -amine compounds targeting the interaction between the bacterial NusB and NusE proteins.
AID1737456	Antibacterial activity against methicillin resistant Staphylococcus aureus ATCC S-28 after 16 to 18 hrs by CLSI-based microbroth dilution method	2020	European journal of medicinal chemistry, Jun-01, Volume: 195	Synthesis of novel monocarbonyl curcuminoids, evaluation of their efficacy against MRSA, including ex vivo infection model and their mechanistic studies.
AID432816	Antimicrobial activity against SCCmec type 1 methicillin-resistant Staphylococcus aureus COL E2125-T2 expressing symporter gene smr1 at 42 degC incubated for 24 hrs by E-test	2008	Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2	Role of a sodium-dependent symporter homologue in the thermosensitivity of beta-lactam antibiotic resistance and cell wall composition in Staphylococcus aureus.
AID564827	Antimicrobial activity against methicillin-resistant coagulase-negative Staphylococcus simulans assessed as resistant isolates after 24 hrs by broth microdilution method	2009	Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10	In vitro activities of panduratin A against clinical Staphylococcus strains.
AID567455	Antimicrobial activity against methicillin-resistant Staphylococcus aureus CGK7 by Etest method	2010	Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9	Development of daptomycin nonsusceptibility with heterogeneous vancomycin-intermediate resistance and oxacillin susceptibility in methicillin-resistant Staphylococcus aureus during high-dose daptomycin treatment.
AID1079942	Steatosis, proven histopathologically. Value is number of references indexed. [column 'STEAT' in source]
AID405477	Antibacterial activity against methicillin-resistant Staphylococcus aureus 2884 isolate at 5 ug by disc diffusion method	2007	Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7	Identification and phenotypic characterization of a beta-lactam-dependent, methicillin-resistant Staphylococcus aureus strain.
AID542388	Antimicrobial activity against Staphylococcus aureus RN4220 transformed with Staphylococcus aureus ST398 plasmid pSCFS3 carrying cfr and fexA genes	2009	Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2	Methicillin-resistant and -susceptible Staphylococcus aureus strains of clonal lineages ST398 and ST9 from swine carry the multidrug resistance gene cfr.
AID544590	Antibacterial activity against Staphylococcus aureus isolate 1306 by agar dilution method	2008	Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11	In vitro and in vivo evaluations of oxacillin efficiency against mecA-positive oxacillin-susceptible Staphylococcus aureus.
AID1763157	Antibacterial activity against methicillin-resistant Staphylococcus aureus 124 assessed as reduction in bacterial growth incubated for 24 hrs by CLSI based serial dilution method	2021	Bioorganic & medicinal chemistry, 05-15, Volume: 38	Antibacterial and synergistic activity of 6β-hydroxy-3-oxolup-20(29)-en-28-oic acid (6β-hydroxy betunolic acid) isolated from Schumacheria castaneifolia vahl.
AID524390	Antibacterial activity against Escherichia coli NKE1316 harboring deletion mutation in acrB, acrD and mdtABC protein	2010	Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5	Effect of NlpE overproduction on multidrug resistance in Escherichia coli.
AID524264	Antibacterial activity against Escherichia coli NKE158 harboring deletion mutation in acrB protein and vector expressing cpxAR gene	2010	Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5	Effect of NlpE overproduction on multidrug resistance in Escherichia coli.
AID276289	Antibacterial activity against vancomycin-resistant Staphylococcus aureus 21083 at 256 ug/ml	2006	Bioorganic & medicinal chemistry letters, Nov-15, Volume: 16, Issue:22	Solid-phase synthesis and antibacterial activity of hydroxycinnamic acid amides and analogues against methicillin-resistant Staphylococcus aureus and vancomycin-resistant S. aureus.
AID1559372	Antibacterial activity against wild type Escherichia coli ATCC 25922 after 16 to 20 hrs by CLSI-based microbroth dilution method	2020	Journal of medicinal chemistry, 03-26, Volume: 63, Issue:6	Discovery of Taniborbactam (VNRX-5133): A Broad-Spectrum Serine- and Metallo-β-lactamase Inhibitor for Carbapenem-Resistant Bacterial Infections.
AID405611	Decrease in thymidylate synthase SA1462 COL gene expression in oxacillin-dependent methicillin-resistant Staphylococcus aureus 2884D isolate at 0.5 ug/ml by microarray-based transcriptional profiling relative to control	2007	Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7	Identification and phenotypic characterization of a beta-lactam-dependent, methicillin-resistant Staphylococcus aureus strain.
AID356963	Antibacterial activity against Enterococcus faecalis after 48 hrs by broth microdilution method	2002	Journal of natural products, Dec, Volume: 65, Issue:12	Antimicrobial activities of naphthazarins from Arnebia euchroma.
AID1559371	Antibacterial activity against methicillin resistant Staphylococcus aureus 33591 after 16 to 20 hrs by CLSI-based microbroth dilution method	2020	Journal of medicinal chemistry, 03-26, Volume: 63, Issue:6	Discovery of Taniborbactam (VNRX-5133): A Broad-Spectrum Serine- and Metallo-β-lactamase Inhibitor for Carbapenem-Resistant Bacterial Infections.
AID484701	Antimicrobial activity against methicillin-resistant Staphylococcus aureus	2010	Bioorganic & medicinal chemistry letters, Jun-15, Volume: 20, Issue:12	Potent antimicrobial activity of 3-(4,5-diaryl-1H-imidazol-2-yl)-1H-indole derivatives against methicillin-resistant Staphylococcus aureus.
AID509053	Antibacterial activity against beta-lactamase positive SCCmec type 2 methicillin-resistant Staphylococcus aureus isolate 15855 by broth microdilution method	2010	Antimicrobial agents and chemotherapy, Feb, Volume: 54, Issue:2	Effects of ceftobiprole and oxacillin on mecA expression in methicillin-resistant Staphylococcus aureus clinical isolates.
AID533931	Antimicrobial activity against linezolid-resistant methicillin-resistant Staphylococcus aureus NRS120 harboring G2576U mutation in peptidyl transferase centre by broth microdilution method	2008	Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12	In vitro activity of TR-700, the antibacterial moiety of the prodrug TR-701, against linezolid-resistant strains.
AID421759	Antibacterial activity against Mycobacterium phlei after 72 hrs	2009	Journal of natural products, Mar-27, Volume: 72, Issue:3	Bioactive pyridine-N-oxide disulfides from Allium stipitatum.
AID509066	Induction of mecA gene expression in beta-lactamase positive SCCmec type 4a methicillin-resistant Staphylococcus aureus isolate 12639 at MIC after 1 hr by multiplex PCR method	2010	Antimicrobial agents and chemotherapy, Feb, Volume: 54, Issue:2	Effects of ceftobiprole and oxacillin on mecA expression in methicillin-resistant Staphylococcus aureus clinical isolates.
AID285935	Antimicrobial activity against methicillin-susceptible Staphylococcus aureus ATCC 29213 in human monocyte-derived macrophages at 0.5 ug/ml assessed as bacterial viability after 24 hrs	2007	Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4	Antimicrobial activities of daptomycin, vancomycin, and oxacillin in human monocytes and of daptomycin in combination with gentamicin and/or rifampin in human monocytes and in broth against Staphylococcus aureus.
AID405610	Decrease in SA2257 N315 gene expression in oxacillin-dependent methicillin-resistant Staphylococcus aureus 2884D isolate at 0.5 ug/ml by microarray-based transcriptional profiling relative to control	2007	Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7	Identification and phenotypic characterization of a beta-lactam-dependent, methicillin-resistant Staphylococcus aureus strain.
AID1294682	Antimicrobial activity against methicillin-resistant Staphylococcus aureus isolate 28a after 24 hrs by agar plate dilution method	2016	European journal of medicinal chemistry, Jun-10, Volume: 115	Anti-methicillin resistant Staphylococcus aureus activity, synergism with oxacillin and molecular docking studies of metronidazole-triazole hybrids.
AID1055332	Antibacterial activity against vancomycin-resistant Enterococcus faecalis R6512 assessed as growth inhibition after 18 hrs by agar dilution method	2013	Journal of natural products, Nov-22, Volume: 76, Issue:11	Identification of elaiophylin derivatives from the marine-derived actinomycete Streptomyces sp. 7-145 using PCR-based screening.
AID1055327	Antibacterial activity against beta-lactamase producing Escherichia coli 09-20 assessed as growth inhibition after 18 hrs by agar dilution method	2013	Journal of natural products, Nov-22, Volume: 76, Issue:11	Identification of elaiophylin derivatives from the marine-derived actinomycete Streptomyces sp. 7-145 using PCR-based screening.
AID1559370	Antibacterial activity against wild type Staphylococcus aureus ATCC 29213 after 16 to 20 hrs by CLSI-based microbroth dilution method	2020	Journal of medicinal chemistry, 03-26, Volume: 63, Issue:6	Discovery of Taniborbactam (VNRX-5133): A Broad-Spectrum Serine- and Metallo-β-lactamase Inhibitor for Carbapenem-Resistant Bacterial Infections.
AID28681	Partition coefficient (logD6.5)	2000	Journal of medicinal chemistry, Jun-29, Volume: 43, Issue:13	QSAR model for drug human oral bioavailability.
AID245060	Minimum inhibitory concentration against methicillin resistant Staphylococcus aureus strain BB 568	2005	Bioorganic & medicinal chemistry letters, May-16, Volume: 15, Issue:10	Synthesis and antibacterial activity of hydrolytically stable (-)-epicatechin gallate analogues for the modulation of beta-lactam resistance in Staphylococcus aureus.
AID562393	Antimicrobial activity against oxacillin-resistant Staphylococcus epidermidis clinical isolates assessed as percent susceptible isolates by broth microdilution method	2009	Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11	Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates.
AID404950	Antibacterial activity against methicillin-susceptible coagulase-negative Staphylococcus sp. assessed as percent susceptible isolates by CLSI dilution method	2007	Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7	In vitro activities of CG400549, a novel FabI inhibitor, against recently isolated clinical staphylococcal strains in Korea.
AID581659	Fraction unbound in human plasma	2009	Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4	Intracellular activity of antibiotics in a model of human THP-1 macrophages infected by a Staphylococcus aureus small-colony variant strain isolated from a cystic fibrosis patient: pharmacodynamic evaluation and comparison with isogenic normal-phenotype a
AID693712	Antibacterial activity against quinolone-resistant Staphylococcus aureus CCARM 3519 after 20 hrs by two fold serial dilution assay	2012	European journal of medicinal chemistry, Dec, Volume: 58	Synthesis and antibacterial activity of novel 1,3-diphenyl-1H-pyrazoles functionalized with phenylalanine-derived rhodanines.
AID581652	Antibacterial activity against Staphylococcus aureus SCV isolated from cystic fibrosis patient in cation-adjusted MH 2 broth assessed as log reduction of extracellular CFU after 24 hrs	2009	Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4	Intracellular activity of antibiotics in a model of human THP-1 macrophages infected by a Staphylococcus aureus small-colony variant strain isolated from a cystic fibrosis patient: pharmacodynamic evaluation and comparison with isogenic normal-phenotype a
AID609219	Antibacterial activity against 10'5 CFU/mL Staphylococcus aureus RN4220 assessed as inhibition of bacterial growth after 24 hrs by microtiter enzyme-linked immunosorbent assay	2011	European journal of medicinal chemistry, Aug, Volume: 46, Issue:8	Synthesis of new chalcone derivatives bearing 2,4-thiazolidinedione and benzoic acid moieties as potential anti-bacterial agents.
AID325153	Antimicrobial activity against Haemophilus parasuis BB 1020	2007	Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6	Beta-lactam resistance in Haemophilus parasuis Is mediated by plasmid pB1000 bearing blaROB-1.
AID750303	Bactericidal activity against Staphylococcus aureus isolate D12 derived from ulcer and furuncle after 18 hrs by broth microdilution method	2013	European journal of medicinal chemistry, Jun, Volume: 64	Synthesis and evaluation of antimicrobial activity of hydrazones derived from 3-oxido-1H-imidazole-4-carbohydrazides.
AID558775	Antibacterial activity against Salmonella enterica ATCC 14028 by CLSI method	2009	Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8	H-NS modulates multidrug resistance of Salmonella enterica serovar Typhimurium by repressing multidrug efflux genes acrEF.
AID1294657	Antimicrobial activity against methicillin-resistant Staphylococcus aureus isolate 3a after 24 hrs by agar plate dilution method	2016	European journal of medicinal chemistry, Jun-10, Volume: 115	Anti-methicillin resistant Staphylococcus aureus activity, synergism with oxacillin and molecular docking studies of metronidazole-triazole hybrids.
AID573117	Antibacterial activity against methicillin-resistant Staphylococcus aureus assessed as susceptible isolates by CLSI M7-A7 broth microdilution method	2008	Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9	In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States.
AID432817	Antimicrobial activity against SCCmec type 1 methicillin-resistant Staphylococcus aureus COL E3005 expressing symporter gene smr1 at 37 degC incubated for 24 hrs by E-test	2008	Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2	Role of a sodium-dependent symporter homologue in the thermosensitivity of beta-lactam antibiotic resistance and cell wall composition in Staphylococcus aureus.
AID529287	Antimicrobial activity against oxacillin-resistant Staphylococcus aureus COLVA harboring Tn1546 transposon by Etest	2008	Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8	Comparative study of the susceptibilities of major epidemic clones of methicillin-resistant Staphylococcus aureus to oxacillin and to the new broad-spectrum cephalosporin ceftobiprole.
AID759324	Antibacterial activity against methicillin-resistant Staphylococcus aureus CCARM 3167 after 24 hrs by broth microdilution method	2013	Bioorganic & medicinal chemistry letters, Aug-01, Volume: 23, Issue:15	Synthesis and biological evaluation of rhodanine derivatives bearing a quinoline moiety as potent antimicrobial agents.
AID1503230	Antibacterial activity against methicillin-resistant Staphylococcus aureus isolate OM505 after 24 hrs by liquid dilution method	2017	Journal of natural products, 10-27, Volume: 80, Issue:10	Structures and Antibacterial Properties of Isorugosins H-J, Oligomeric Ellagitannins from Liquidambar formosana with Characteristic Bridging Groups between Sugar Moieties.
AID761555	Antibacterial activity against Bacillus licheniformis EMR by M07-A9 CLSI method	2013	Bioorganic & medicinal chemistry letters, Aug-01, Volume: 23, Issue:15	Synthesis and antimicrobial activity of imidazole and pyridine appended cholestane-based conjugates.
AID1651742	Antibacterial activity against Vancomycin resistant Enterococcus casseliflavus MB159 after 24 hrs by microdilution assay	2020	Journal of natural products, 04-24, Volume: 83, Issue:4	Antibacterial and ATP Synthesis Modulating Compounds from
AID1651734	Antibacterial activity against Vancomycin resistant Enterococcus faecalis MB1 after 24 hrs by microdilution assay	2020	Journal of natural products, 04-24, Volume: 83, Issue:4	Antibacterial and ATP Synthesis Modulating Compounds from
AID405476	Antibacterial activity against methicillin-resistant Staphylococcus aureus 2884 isolate assessed as decrease in log bacterial count at 1 ug/ml	2007	Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7	Identification and phenotypic characterization of a beta-lactam-dependent, methicillin-resistant Staphylococcus aureus strain.
AID1601853	Antibacterial activity against multidrug-resistant Escherichia coli ATCC BAA-196 measured after 24 hrs by ELISA	2019	European journal of medicinal chemistry, Mar-15, Volume: 166	Synthesis, antimicrobial and cytotoxic activities, and molecular docking studies of N-arylsulfonylindoles containing an aminoguanidine, a semicarbazide, and a thiosemicarbazide moiety.
AID581669	Antibacterial activity against normal phenotype Staphylococcus aureus in infected in human THP-1 cells assessed as log reduction of extracellular CFU level after 24 hrs	2009	Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4	Intracellular activity of antibiotics in a model of human THP-1 macrophages infected by a Staphylococcus aureus small-colony variant strain isolated from a cystic fibrosis patient: pharmacodynamic evaluation and comparison with isogenic normal-phenotype a
AID425865	Antimicrobial activity against Carnobacterium divergens BM4489 expressing beta-lactamase CAD1 at 0.5 McFarland inoculum size by E-test	2008	Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2	Genetic and biochemical characterization of CAD-1, a chromosomally encoded new class A penicillinase from Carnobacterium divergens.
AID340858	Antimicrobial activity against wild type vancomycin-intermediate resistant Staphylococcus aureus Mu50 by microdilution assay	2007	Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8	Interaction of the GraRS two-component system with the VraFG ABC transporter to support vancomycin-intermediate resistance in Staphylococcus aureus.
AID570769	Antimicrobial activity against hospital-acquired pbp4-deficient Staphylococcus aureus N315 serotype USA100 by microdilution method	2008	Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11	Staphylococcus aureus PBP4 is essential for beta-lactam resistance in community-acquired methicillin-resistant strains.
AID429362	Antimicrobial activity against methicillin-resistant Staphylococcus aureus isolate 6	2009	Bioorganic & medicinal chemistry letters, Aug-15, Volume: 19, Issue:16	Isoplatensimycin: Synthesis and biological evaluation.
AID1428626	Antibacterial activity against methicillin-resistant Staphylococcus aureus USA300 by broth microdilution method	2017	European journal of medicinal chemistry, Feb-15, Volume: 127	Diaryltriazenes as antibacterial agents against methicillin resistant Staphylococcus aureus (MRSA) and Mycobacterium smegmatis.
AID609221	Antibacterial activity against 10'5 CFU/mL Escherichia coli 1356 assessed as inhibition of bacterial growth after 24 hrs by microtiter enzyme-linked immunosorbent assay	2011	European journal of medicinal chemistry, Aug, Volume: 46, Issue:8	Synthesis of new chalcone derivatives bearing 2,4-thiazolidinedione and benzoic acid moieties as potential anti-bacterial agents.
AID694211	Induction of Staphylococcus aureus FtsZ self-polymerization assessed as increase in light scattering at 20 ug/mL measured every 5 secs by 90 deg angle light scattering assay	2012	Bioorganic & medicinal chemistry letters, Nov-15, Volume: 22, Issue:22	Antibacterial activity of substituted dibenzo[a,g]quinolizin-7-ium derivatives.
AID1055331	Antibacterial activity against vancomycin-resistant Enterococcus faecium ATCC 700221 assessed as growth inhibition after 18 hrs by agar dilution method	2013	Journal of natural products, Nov-22, Volume: 76, Issue:11	Identification of elaiophylin derivatives from the marine-derived actinomycete Streptomyces sp. 7-145 using PCR-based screening.
AID574300	Antimicrobial activity against community-acquired pbp4::pbp4-deficient Staphylococcus aureus USA300 by microdilution method	2008	Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11	Staphylococcus aureus PBP4 is essential for beta-lactam resistance in community-acquired methicillin-resistant strains.
AID1438624	Antibacterial activity against daptomycin-resistant Staphylococcus aureus isolate ST 2015-0188 after 18 hrs by broth microdilution assay	2017	European journal of medicinal chemistry, Mar-10, Volume: 128	Synthesis, surfactant properties and antimicrobial activities of methyl glycopyranoside ethers.
AID519454	Antimicrobial activity against homotypic oxacillin resistant and vancomycin intermediate resistant Staphylococcus aureus isolate 5827 by broth microdilution method	2008	Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4	Spontaneous deletion of the methicillin resistance determinant, mecA, partially compensates for the fitness cost associated with high-level vancomycin resistance in Staphylococcus aureus.
AID508837	Induction of mecA gene expression in beta-lactamase positive SCCmec type 3 methicillin-resistant Staphylococcus aureus isolate 12617 at MIC after 1 hr by multiplex PCR method	2010	Antimicrobial agents and chemotherapy, Feb, Volume: 54, Issue:2	Effects of ceftobiprole and oxacillin on mecA expression in methicillin-resistant Staphylococcus aureus clinical isolates.
AID564823	Antimicrobial activity against methicillin-susceptible Staphylococcus aureus assessed as resistant isolates after 24 hrs by broth microdilution method	2009	Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10	In vitro activities of panduratin A against clinical Staphylococcus strains.
AID1601851	Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC 43300 measured after 24 hrs by ELISA	2019	European journal of medicinal chemistry, Mar-15, Volume: 166	Synthesis, antimicrobial and cytotoxic activities, and molecular docking studies of N-arylsulfonylindoles containing an aminoguanidine, a semicarbazide, and a thiosemicarbazide moiety.
AID285917	Antimicrobial activity against methicillin-resistant Staphylococcus aureus 8111	2007	Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4	Antimicrobial activities of daptomycin, vancomycin, and oxacillin in human monocytes and of daptomycin in combination with gentamicin and/or rifampin in human monocytes and in broth against Staphylococcus aureus.
AID421757	Antibacterial activity against Mycobacterium smegmatis after 72 hrs	2009	Journal of natural products, Mar-27, Volume: 72, Issue:3	Bioactive pyridine-N-oxide disulfides from Allium stipitatum.
AID285930	Antimicrobial activity against methicillin-susceptible Staphylococcus aureus ATCC 29213 in human monocyte-derived macrophages at 0.25 ug/ml assessed as bacterial viability after 2 hrs	2007	Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4	Antimicrobial activities of daptomycin, vancomycin, and oxacillin in human monocytes and of daptomycin in combination with gentamicin and/or rifampin in human monocytes and in broth against Staphylococcus aureus.
AID574301	Antimicrobial activity against wild type hospital-acquired methicillin-resistant Staphylococcus aureus COL serotype USA500 by microdilution method	2008	Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11	Staphylococcus aureus PBP4 is essential for beta-lactam resistance in community-acquired methicillin-resistant strains.
AID1324846	Antimicrobial activity against Enterococcus faecium ATCC 51299 by CLSI M07-A9 method	2016	Journal of natural products, 07-22, Volume: 79, Issue:7	Polybrominated Diphenyl Ethers: Structure Determination and Trends in Antibacterial Activity.
AID542622	Antimicrobial activity against Streptococcus pneumoniae R6 harboring PBP2x T338A mutant gene, disruption at PBP1a and aad9 disruption in CiaR gene after 48 hrs by agar dilution method	2009	Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3	An important site in PBP2x of penicillin-resistant clinical isolates of Streptococcus pneumoniae: mutational analysis of Thr338.
AID529289	Bactericidal activity against methicillin-resistant Staphylococcus aureus COL assessed as reduction in viable bacterial titer after 24 hrs at 10 times MIC	2008	Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8	Comparative study of the susceptibilities of major epidemic clones of methicillin-resistant Staphylococcus aureus to oxacillin and to the new broad-spectrum cephalosporin ceftobiprole.
AID1294658	Antimicrobial activity against methicillin-resistant Staphylococcus aureus isolate 4a after 24 hrs by agar plate dilution method	2016	European journal of medicinal chemistry, Jun-10, Volume: 115	Anti-methicillin resistant Staphylococcus aureus activity, synergism with oxacillin and molecular docking studies of metronidazole-triazole hybrids.
AID405596	Increase in general stress protein 13 expression in oxacillin-dependent methicillin-resistant Staphylococcus aureus 2884D isolate at 0.5 ug/ml by microarray-based transcriptional profiling relative to control	2007	Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7	Identification and phenotypic characterization of a beta-lactam-dependent, methicillin-resistant Staphylococcus aureus strain.
AID546187	Antimicrobial activity against methicillin-resistant Staphylococcus aureus 85/2082 by broth dilution method	2010	Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8	Identification of a novel transposon (Tn6072) and a truncated staphylococcal cassette chromosome mec element in methicillin-resistant Staphylococcus aureus ST239.
AID574294	Antimicrobial activity against wild type community-acquired methicillin-resistant Staphylococcus aureus MW2 ex serotype USA400 by microdilution method	2008	Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11	Staphylococcus aureus PBP4 is essential for beta-lactam resistance in community-acquired methicillin-resistant strains.
AID581658	Cmax in human plasma	2009	Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4	Intracellular activity of antibiotics in a model of human THP-1 macrophages infected by a Staphylococcus aureus small-colony variant strain isolated from a cystic fibrosis patient: pharmacodynamic evaluation and comparison with isogenic normal-phenotype a
AID325448	Antibacterial activity against Staphylococcus aureus Mu50 after 14 to 16 hrs by broth dilution method	2007	Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6	Polyamine effects on antibiotic susceptibility in bacteria.
AID581670	Antibacterial activity against Staphylococcus aureus SCV isolated from cystic fibrosis patient in cation-adjusted MH 2 broth at pH 5.5 after 48 hrs by broth microdilution method	2009	Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4	Intracellular activity of antibiotics in a model of human THP-1 macrophages infected by a Staphylococcus aureus small-colony variant strain isolated from a cystic fibrosis patient: pharmacodynamic evaluation and comparison with isogenic normal-phenotype a
AID525586	Antimicrobial activity against Macrococcus caseolyticus ATCC 13548T by agar dilution method	2010	Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4	Staphylococcal cassette chromosome mec-like element in Macrococcus caseolyticus.
AID528501	Antimicrobial activity against levofloxacin-sensitive and methicillin-resistant Staphylococcus aureus JCSC 6770 by broth microdilution method	2008	Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8	Postantibiotic effects and bactericidal activities of levofloxacin and gatifloxacin at concentrations simulating those of topical ophthalmic administration against fluoroquinolone-resistant and fluoroquinolone-sensitive methicillin-resistant Staphylococcu
AID570773	Antimicrobial activity against community-acquired pbp4-deficient Staphylococcus aureus USA300 by microdilution method relative to wild type	2008	Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11	Staphylococcus aureus PBP4 is essential for beta-lactam resistance in community-acquired methicillin-resistant strains.
AID750310	Antibacterial activity against Staphylococcus aureus isolate D15 derived from bone assessed as growth inhibition after 18 hrs by broth microdilution method	2013	European journal of medicinal chemistry, Jun, Volume: 64	Synthesis and evaluation of antimicrobial activity of hydrazones derived from 3-oxido-1H-imidazole-4-carbohydrazides.
AID761562	Antibacterial activity against Staphylococcus aureus 77 by M07-A9 CLSI method	2013	Bioorganic & medicinal chemistry letters, Aug-01, Volume: 23, Issue:15	Synthesis and antimicrobial activity of imidazole and pyridine appended cholestane-based conjugates.
AID573114	Antibacterial activity against methicillin-susceptible Staphylococcus aureus assessed as susceptible isolates by CLSI M7-A7 broth microdilution method	2008	Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9	In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States.
AID528528	Antimicrobial activity against penicillin-resistant Streptococcus agalactiae B10 by agar dilution method	2008	Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8	First molecular characterization of group B streptococci with reduced penicillin susceptibility.
AID718543	Antibacterial activity against quinolone-resistant Staphylococcus aureus CCARM 3519 incubated for 24 hrs serial dilution method	2012	Bioorganic & medicinal chemistry letters, Dec-01, Volume: 22, Issue:23	Synthesis and biological evaluation of 5-aryloxypyrazole derivatives bearing a rhodanine-3-aromatic acid as potential antimicrobial agents.
AID533938	Antimicrobial activity against linezolid-resistant Staphylococcus aureus 425 harboring G2447U in peptidyl transferase centre by broth microdilution method	2008	Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12	In vitro activity of TR-700, the antibacterial moiety of the prodrug TR-701, against linezolid-resistant strains.
AID521065	Antibacterial activity against group 1 PVL+ community-acquired methicillin-resistant Staphylococcus aureus ST 59 expressing SCCmec type VT gene by agar dilution method	2008	Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3	Novel characteristics of community-acquired methicillin-resistant Staphylococcus aureus strains belonging to multilocus sequence type 59 in Taiwan.
AID583687	Antimicrobial activity against methicillin-resistant Staphylococcus aureus N315deltaIP harboring rpoB 621E mutant after 24 hrs by Etest method	2010	Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12	An RpoB mutation confers dual heteroresistance to daptomycin and vancomycin in Staphylococcus aureus.
AID637225	Antibacterial activity against methicillin-resistant Staphylococcus aureus CCARM 3167 after 20 hrs by twofold serial dilution technique	2012	European journal of medicinal chemistry, Feb, Volume: 48	Synthesis of novel 1,3-diaryl pyrazole derivatives bearing rhodanine-3-fatty acid moieties as potential antibacterial agents.
AID529285	Antimicrobial activity against vancomycin-intermediate Staphylococcus aureus JH9 obtained from bacteremic patient by Etest	2008	Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8	Comparative study of the susceptibilities of major epidemic clones of methicillin-resistant Staphylococcus aureus to oxacillin and to the new broad-spectrum cephalosporin ceftobiprole.
AID528502	Antimicrobial activity against levofloxacin-sensitive and methicillin-resistant Staphylococcus aureus JCSC 6822 harboring mutation in norA gene by broth microdilution method	2008	Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8	Postantibiotic effects and bactericidal activities of levofloxacin and gatifloxacin at concentrations simulating those of topical ophthalmic administration against fluoroquinolone-resistant and fluoroquinolone-sensitive methicillin-resistant Staphylococcu
AID524387	Antibacterial activity against Escherichia coli NKE1365 harboring deletion mutation in acrB and mdtABC protein	2010	Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5	Effect of NlpE overproduction on multidrug resistance in Escherichia coli.
AID560523	Antimicrobial activity against SCCmec type III vancomycin-intermediate Staphylococcus aureus isolate gs07022 by agar dilution method	2009	Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9	Prevalence and characterization of heterogeneous vancomycin-intermediate Staphylococcus aureus isolates from 14 cities in China.
AID558781	Antibacterial activity against acrB-deficient Salmonella enterica NKS422 harboring acrEF gene by CLSI method	2009	Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8	H-NS modulates multidrug resistance of Salmonella enterica serovar Typhimurium by repressing multidrug efflux genes acrEF.
AID1055338	Antibacterial activity against methicillin-sensitive Staphylococcus epidermidis 09-9 assessed as growth inhibition after 18 hrs by agar dilution method	2013	Journal of natural products, Nov-22, Volume: 76, Issue:11	Identification of elaiophylin derivatives from the marine-derived actinomycete Streptomyces sp. 7-145 using PCR-based screening.
AID325150	Antimicrobial activity against Haemophilus parasuis ATCC 19417	2007	Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6	Beta-lactam resistance in Haemophilus parasuis Is mediated by plasmid pB1000 bearing blaROB-1.
AID1294665	Antimicrobial activity against methicillin-resistant Staphylococcus aureus isolate 11a after 24 hrs by agar plate dilution method	2016	European journal of medicinal chemistry, Jun-10, Volume: 115	Anti-methicillin resistant Staphylococcus aureus activity, synergism with oxacillin and molecular docking studies of metronidazole-triazole hybrids.
AID431092	Antibacterial activity against vancomycin-susceptible Staphylococcus aureus N315 after 24 hrs by agar dilution method	2008	Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1	Mutated response regulator graR is responsible for phenotypic conversion of Staphylococcus aureus from heterogeneous vancomycin-intermediate resistance to vancomycin-intermediate resistance.
AID533930	Antimicrobial activity against linezolid-resistant methicillin-resistant Staphylococcus aureus NRS119 harboring G2576U mutation in peptidyl transferase centre by broth microdilution method	2008	Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12	In vitro activity of TR-700, the antibacterial moiety of the prodrug TR-701, against linezolid-resistant strains.
AID509065	Induction of mecA gene expression in beta-lactamase positive SCCmec type 4a methicillin-resistant Staphylococcus aureus isolate 11617 at MIC after 1 hr by multiplex PCR method	2010	Antimicrobial agents and chemotherapy, Feb, Volume: 54, Issue:2	Effects of ceftobiprole and oxacillin on mecA expression in methicillin-resistant Staphylococcus aureus clinical isolates.
AID1870137	Antibacterial activity against wild type methicillin resistant Staphylococcus aureus 4561/A assessed as reduction in microbial growth incubated for 24 hrs by microdilution assay	2022	Journal of medicinal chemistry, 07-28, Volume: 65, Issue:14	LEGO-Lipophosphonoxins: A Novel Approach in Designing Membrane Targeting Antimicrobials.
AID529115	Antimicrobial activity against methicillin-resistant Staphylococcus aureus BK2529 by Etest	2008	Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8	Comparative study of the susceptibilities of major epidemic clones of methicillin-resistant Staphylococcus aureus to oxacillin and to the new broad-spectrum cephalosporin ceftobiprole.
AID432815	Antimicrobial activity against SCCmec type 1 methicillin-resistant Staphylococcus aureus COL E2125-T2 expressing symporter gene smr1 at 37 degC incubated for 24 hrs by E-test	2008	Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2	Role of a sodium-dependent symporter homologue in the thermosensitivity of beta-lactam antibiotic resistance and cell wall composition in Staphylococcus aureus.
AID528534	Antimicrobial activity against penicillin-resistant Streptococcus agalactiae B503 by agar dilution method	2008	Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8	First molecular characterization of group B streptococci with reduced penicillin susceptibility.
AID546184	Antimicrobial activity against methicillin-resistant Staphylococcus aureus 16703 by broth dilution method	2010	Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8	Identification of a novel transposon (Tn6072) and a truncated staphylococcal cassette chromosome mec element in methicillin-resistant Staphylococcus aureus ST239.
AID533932	Antimicrobial activity against linezolid-resistant methicillin-resistant Staphylococcus aureus NRS121 harboring G2576U mutation in peptidyl transferase centre by broth microdilution method	2008	Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12	In vitro activity of TR-700, the antibacterial moiety of the prodrug TR-701, against linezolid-resistant strains.
AID637226	Antibacterial activity against methicillin-resistant Staphylococcus aureus CCARM 3506 after 20 hrs by twofold serial dilution technique	2012	European journal of medicinal chemistry, Feb, Volume: 48	Synthesis of novel 1,3-diaryl pyrazole derivatives bearing rhodanine-3-fatty acid moieties as potential antibacterial agents.
AID544602	Effect on growth of Staphylococcus aureus isolate 2712 assessed as highest compound concentration at which cell growth occurred measured after 48 hrs	2008	Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11	In vitro and in vivo evaluations of oxacillin efficiency against mecA-positive oxacillin-susceptible Staphylococcus aureus.
AID545954	Antimicrobial activity against methicillin-resistant Staphylococcus aureus 16656 by broth dilution method	2010	Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8	Identification of a novel transposon (Tn6072) and a truncated staphylococcal cassette chromosome mec element in methicillin-resistant Staphylococcus aureus ST239.
AID431098	Antibacterial activity against vancomycin-susceptible Staphylococcus aureus N315 harboring intact graR gene after 24 hrs by agar dilution method	2008	Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1	Mutated response regulator graR is responsible for phenotypic conversion of Staphylococcus aureus from heterogeneous vancomycin-intermediate resistance to vancomycin-intermediate resistance.
AID431111	Antibacterial activity against heterogeneous vancomycin-intermediate Staphylococcus aureus Mu3 harboring mutated graR gene after 48 hrs by agar dilution method	2008	Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1	Mutated response regulator graR is responsible for phenotypic conversion of Staphylococcus aureus from heterogeneous vancomycin-intermediate resistance to vancomycin-intermediate resistance.
AID1897215	Antibacterial activity against Acinetobacter baumannii assessed as planktonic growth inhibition incubated for 18 to 24 hrs by CLSI protocol based assay	2022	Bioorganic & medicinal chemistry, 12-15, Volume: 76	Synthesis and antibiofilm evaluation of N-acyl-2-aminopyrimidine derivatives against Acinetobacter baumannii.
AID1517067	Antibacterial activity against Staphylococcus aureus ATCC 6538 assessed as reduction in bacterial growth incubated for 24 hrs by serial dilution method	2019	European journal of medicinal chemistry, Dec-01, Volume: 183	Two optimized antimicrobial peptides with therapeutic potential for clinical antibiotic-resistant Staphylococcus aureus.
AID1888846	Antibacterial activity against Staphylococcus aureus 1199B measured after 24 hrs by Muller Hinton broth based MTT assay	2022	Bioorganic & medicinal chemistry, 01-15, Volume: 54	Potentiating the intracellular killing of Staphylococcus aureus by dihydroquinazoline analogues as NorA efflux pump inhibitor.
AID581667	Antibacterial activity against Staphylococcus aureus SCV isolated from cystic fibrosis patient infected in human THP-1 cells assessed as log reduction of intracellular CFU level after 24 hrs in presence of thymidine	2009	Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4	Intracellular activity of antibiotics in a model of human THP-1 macrophages infected by a Staphylococcus aureus small-colony variant strain isolated from a cystic fibrosis patient: pharmacodynamic evaluation and comparison with isogenic normal-phenotype a
AID750341	Antibacterial activity against Proteus mirabilis ATCC 29906 assessed as growth inhibition after 18 hrs by broth microdilution method	2013	European journal of medicinal chemistry, Jun, Volume: 64	Synthesis and evaluation of antimicrobial activity of hydrazones derived from 3-oxido-1H-imidazole-4-carbohydrazides.
AID1055345	Antibacterial activity against methicillin-sensitive Staphylococcus epidermidis ATCC 12228 assessed as growth inhibition after 18 hrs by agar dilution method	2013	Journal of natural products, Nov-22, Volume: 76, Issue:11	Identification of elaiophylin derivatives from the marine-derived actinomycete Streptomyces sp. 7-145 using PCR-based screening.
AID574543	Activity of Quorum sensing agr in community-associated methicillin-resistant Staphylococcus aureus USA300 assessed as PSMalpha expression after 8 hrs by qRT-PCR	2010	Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11	Subinhibitory concentrations of protein synthesis-inhibiting antibiotics promote increased expression of the agr virulence regulator and production of phenol-soluble modulin cytolysins in community-associated methicillin-resistant Staphylococcus aureus.
AID528532	Antimicrobial activity against penicillin-resistant Streptococcus agalactiae B68 by agar dilution method	2008	Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8	First molecular characterization of group B streptococci with reduced penicillin susceptibility.
AID528740	Antimicrobial activity against penicillin-resistant Streptococcus agalactiae ATCC BAA-611 harboring PBP-2X Q557E mutant gene by agar dilution method	2008	Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8	First molecular characterization of group B streptococci with reduced penicillin susceptibility.
AID584481	Antibacterial activity against mecA-negative Staphylococcus vitulinus SVMN11 by agar dilution method	2010	Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10	Origin and molecular evolution of the determinant of methicillin resistance in staphylococci.
AID1870158	Antibacterial activity against wild type Staphylococcus aureus 4788/B assessed as reduction in microbial growth incubated for 24 hrs by microdilution assay	2022	Journal of medicinal chemistry, 07-28, Volume: 65, Issue:14	LEGO-Lipophosphonoxins: A Novel Approach in Designing Membrane Targeting Antimicrobials.
AID529128	Antimicrobial activity against methicillin-resistant Staphylococcus aureus USA300 assessed as concentration required for bacterial subpopulation growth	2008	Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8	Comparative study of the susceptibilities of major epidemic clones of methicillin-resistant Staphylococcus aureus to oxacillin and to the new broad-spectrum cephalosporin ceftobiprole.
AID1245571	Antibacterial activity against Staphylococcus aureus ATCC 29213 after 24 hrs by broth microdilution method	2015	Bioorganic & medicinal chemistry, Oct-01, Volume: 23, Issue:19	Deprotometalation-iodolysis and computed CH acidity of 1,2,3- and 1,2,4-triazoles. Application to the synthesis of resveratrol analogues.
AID564229	Ratio of Kcat to Km for Escherichia coli TOP10 beta-lactamase OXA-143	2009	Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12	OXA-143, a novel carbapenem-hydrolyzing class D beta-lactamase in Acinetobacter baumannii.
AID529294	Inhibition of methicillin-resistant Staphylococcus aureus COL PBP2a by competitive assay	2008	Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8	Comparative study of the susceptibilities of major epidemic clones of methicillin-resistant Staphylococcus aureus to oxacillin and to the new broad-spectrum cephalosporin ceftobiprole.
AID685407	Antibacterial activity against quinolone-resistant Staphylococcus aureus CCARM 3505 clinical isolate after 24 hrs by broth microdilution method	2012	European journal of medicinal chemistry, Oct, Volume: 56	Synthesis and antimicrobial evaluation of L-phenylalanine-derived C5-substituted rhodanine and chalcone derivatives containing thiobarbituric acid or 2-thioxo-4-thiazolidinone.
AID432975	Antimicrobial activity against SCCmec type 3 methicillin-resistant Staphylococcus aureus COL 301-T6 expressing symporter gene smr1 at 37 degC incubated for 24 hrs by E-test	2008	Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2	Role of a sodium-dependent symporter homologue in the thermosensitivity of beta-lactam antibiotic resistance and cell wall composition in Staphylococcus aureus.
AID528521	Antimicrobial activity against penicillin-resistant Streptococcus agalactiae ATCC BAA-611 by agar dilution method	2008	Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8	First molecular characterization of group B streptococci with reduced penicillin susceptibility.
AID529134	Antimicrobial activity against methicillin-resistant Staphylococcus aureus HDE288 assessed as concentration required for minimum inhibition of oxacillin-resistant subpopulation growth by Etest	2008	Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8	Comparative study of the susceptibilities of major epidemic clones of methicillin-resistant Staphylococcus aureus to oxacillin and to the new broad-spectrum cephalosporin ceftobiprole.
AID625280	Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for cholecystitis	2011	PLoS computational biology, Dec, Volume: 7, Issue:12	Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
AID721792	Antibacterial activity against methicillin-sensitive Staphylococcus aureus 8325-4 assessed as growth inhibition after 24 hrs by CLSI broth microdilution method	2013	European journal of medicinal chemistry, Feb, Volume: 60	Antimicrobial activity of various 4- and 5-substituted 1-phenylnaphthalenes.
AID1294683	Antimicrobial activity against methicillin-resistant Staphylococcus aureus isolate 29a after 24 hrs by agar plate dilution method	2016	European journal of medicinal chemistry, Jun-10, Volume: 115	Anti-methicillin resistant Staphylococcus aureus activity, synergism with oxacillin and molecular docking studies of metronidazole-triazole hybrids.
AID1870146	Antibacterial activity against wild type Staphylococcus aureus 4460/A assessed as reduction in microbial growth incubated for 24 hrs by microdilution assay	2022	Journal of medicinal chemistry, 07-28, Volume: 65, Issue:14	LEGO-Lipophosphonoxins: A Novel Approach in Designing Membrane Targeting Antimicrobials.
AID571767	Antimicrobial activity against Escherichia coli K-12 3-AG300 harboring AcrB-615-628MexB-M626I mutant gene	2009	Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1	Site-directed mutagenesis reveals amino acid residues in the Escherichia coli RND efflux pump AcrB that confer macrolide resistance.
AID544596	Antibacterial activity against mecA-negative Staphylococcus aureus isolate 29213 by agar dilution method	2008	Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11	In vitro and in vivo evaluations of oxacillin efficiency against mecA-positive oxacillin-susceptible Staphylococcus aureus.
AID559508	Antibacterial activity against Staphylococcus warneri assessed as percent susceptible isolates by CLSI M100-S18 method	2009	Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8	Besifloxacin, a novel fluoroquinolone, has broad-spectrum in vitro activity against aerobic and anaerobic bacteria.
AID405616	Decrease in alanine dehydrogenase gene expression in oxacillin-dependent methicillin-resistant Staphylococcus aureus 2884D isolate at 0.5 ug/ml by microarray-based transcriptional profiling relative to control	2007	Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7	Identification and phenotypic characterization of a beta-lactam-dependent, methicillin-resistant Staphylococcus aureus strain.
AID584295	Antibacterial activity against methicillin-resistant mecA-positive Staphylococcus fleurettii SFMP05 by agar dilution method	2010	Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10	Origin and molecular evolution of the determinant of methicillin resistance in staphylococci.
AID567450	Antimicrobial activity against methicillin-resistant Staphylococcus aureus CGK2 by Etest method	2010	Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9	Development of daptomycin nonsusceptibility with heterogeneous vancomycin-intermediate resistance and oxacillin susceptibility in methicillin-resistant Staphylococcus aureus during high-dose daptomycin treatment.
AID429358	Antimicrobial activity against methicillin-susceptible Staphylococcus aureus isolate 2	2009	Bioorganic & medicinal chemistry letters, Aug-15, Volume: 19, Issue:16	Isoplatensimycin: Synthesis and biological evaluation.
AID323867	Antibacterial activity against methicillin-resistant Staphylococcus aureus 459 at pH 7.4	2007	Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5	Role of acidic pH in the susceptibility of intraphagocytic methicillin-resistant Staphylococcus aureus strains to meropenem and cloxacillin.
AID524385	Antibacterial activity against Escherichia coli NKE156 harboring deletion mutation in acrB protein and vector expressing acrD gene	2010	Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5	Effect of NlpE overproduction on multidrug resistance in Escherichia coli.
AID325447	Antibacterial activity against Staphylococcus aureus N315 after 14 to 16 hrs by broth dilution method	2007	Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6	Polyamine effects on antibiotic susceptibility in bacteria.
AID432808	Antimicrobial activity against SCCmec type 1 methicillin-resistant Staphylococcus aureus COL C245Td expressing symporter gene smr1 at 42 degC incubated for 24 hrs by E-test	2008	Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2	Role of a sodium-dependent symporter homologue in the thermosensitivity of beta-lactam antibiotic resistance and cell wall composition in Staphylococcus aureus.
AID545971	Antimicrobial activity against methicillin-resistant Staphylococcus aureus 16679 by broth dilution method	2010	Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8	Identification of a novel transposon (Tn6072) and a truncated staphylococcal cassette chromosome mec element in methicillin-resistant Staphylococcus aureus ST239.
AID570781	Antimicrobial activity against wild type hospital-acquired methicillin-resistant vancomycin-intermediate Staphylococcus aureus Mu50 after 48 hrs by microdilution method	2008	Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11	Staphylococcus aureus PBP4 is essential for beta-lactam resistance in community-acquired methicillin-resistant strains.
AID67728	Minimum inhibitory activity against Enterococcus faecalis OC3041.	1998	Journal of medicinal chemistry, Jul-30, Volume: 41, Issue:16	Substituted salicylanilides as inhibitors of two-component regulatory systems in bacteria.
AID1503231	Antibacterial activity against Pseudomonas aeruginosa PAO1 after 24 hrs by liquid dilution method	2017	Journal of natural products, 10-27, Volume: 80, Issue:10	Structures and Antibacterial Properties of Isorugosins H-J, Oligomeric Ellagitannins from Liquidambar formosana with Characteristic Bridging Groups between Sugar Moieties.
AID584479	Antibacterial activity against mecA-negative Staphylococcus vitulinus SVMN09 by agar dilution method	2010	Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10	Origin and molecular evolution of the determinant of methicillin resistance in staphylococci.
AID529296	Inhibition of methicillin-resistant Staphylococcus aureus COL PBP2a at 10 uM by competitive assay	2008	Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8	Comparative study of the susceptibilities of major epidemic clones of methicillin-resistant Staphylococcus aureus to oxacillin and to the new broad-spectrum cephalosporin ceftobiprole.
AID66285	Inhibition of growth of Vancomycin resistant Enterococcus faecalis (VRE) OC 3312.	2001	Bioorganic & medicinal chemistry letters, Jun-18, Volume: 11, Issue:12	Amidino benzimidazole inhibitors of bacterial two-component systems.
AID519458	Antimicrobial activity against oxacillin sensitive and vancomycin resistant Staphylococcus aureus isolate 5836VR by broth microdilution method	2008	Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4	Spontaneous deletion of the methicillin resistance determinant, mecA, partially compensates for the fitness cost associated with high-level vancomycin resistance in Staphylococcus aureus.
AID558776	Antibacterial activity against acrB-deficient Salmonella enterica NKS175 by CLSI method	2009	Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8	H-NS modulates multidrug resistance of Salmonella enterica serovar Typhimurium by repressing multidrug efflux genes acrEF.
AID761561	Antibacterial activity against Staphylococcus aureus 241 by M07-A9 CLSI method	2013	Bioorganic & medicinal chemistry letters, Aug-01, Volume: 23, Issue:15	Synthesis and antimicrobial activity of imidazole and pyridine appended cholestane-based conjugates.
AID548128	Antibacterial activity against Staphylococcus aureus KCTC 209 after 20 hrs by twofold serial dilution technique	2010	European journal of medicinal chemistry, Dec, Volume: 45, Issue:12	Synthesis of new chalcone derivatives containing a rhodanine-3-acetic acid moiety with potential anti-bacterial activity.
AID625287	Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for hepatomegaly	2011	PLoS computational biology, Dec, Volume: 7, Issue:12	Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
AID542615	Antimicrobial activity against Streptococcus pneumoniae R6 harboring PBP2x T338G mutant gene after 48 hrs by agar dilution method	2009	Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3	An important site in PBP2x of penicillin-resistant clinical isolates of Streptococcus pneumoniae: mutational analysis of Thr338.
AID1651729	Antibacterial activity against Methicillin-resistant Staphylococcus warneri MB74 after 24 hrs by microdilution assay	2020	Journal of natural products, 04-24, Volume: 83, Issue:4	Antibacterial and ATP Synthesis Modulating Compounds from
AID573120	Antibacterial activity against coagulase-negative and oxacillin-susceptible Staphylococcus aureus assessed as susceptible isolates by CLSI M7-A7 broth microdilution method	2008	Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9	In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States.
AID519451	Antimicrobial activity against homotypic oxacillin resistant and vancomycin sensitive Staphylococcus aureus isolate 3130 by broth microdilution method	2008	Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4	Spontaneous deletion of the methicillin resistance determinant, mecA, partially compensates for the fitness cost associated with high-level vancomycin resistance in Staphylococcus aureus.
AID207670	Minimum inhibitory activity against Staphylococcus aureus ATCC 29213.	1998	Journal of medicinal chemistry, Jul-30, Volume: 41, Issue:16	Substituted salicylanilides as inhibitors of two-component regulatory systems in bacteria.
AID1524628	Antibacterial activity against quinolone-resistant Staphylococcus aureus CCARM 3505 after 24 hrs by microtiter ELISA	2019	Bioorganic & medicinal chemistry letters, 05-01, Volume: 29, Issue:9	Synthesis of novel dihydrotriazine derivatives bearing 1,3-diaryl pyrazole moieties as potential antibacterial agents.
AID425652	Total body clearance in human	2009	Journal of medicinal chemistry, Aug-13, Volume: 52, Issue:15	Physicochemical determinants of human renal clearance.
AID562390	Antimicrobial activity against oxacillin-resistant Staphylococcus haemolyticus clinical isolates assessed as percent susceptible isolates by broth microdilution method	2009	Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11	Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates.
AID625284	Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for hepatic failure	2011	PLoS computational biology, Dec, Volume: 7, Issue:12	Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
AID558753	Antibacterial activity against homo-Methicillin-resistant and tetracycline-resistant Staphylococcus aureus H14 harboring vraS S329L mutant gene by Etest method	2009	Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8	Selection of heterogeneous vancomycin-intermediate Staphylococcus aureus by imipenem.
AID429363	Antimicrobial activity against methicillin-resistant Staphylococcus aureus isolate 7	2009	Bioorganic & medicinal chemistry letters, Aug-15, Volume: 19, Issue:16	Isoplatensimycin: Synthesis and biological evaluation.
AID570776	Antimicrobial activity against community-acquired pbp4-deficient Staphylococcus aureus MW2 ex serotype USA400 by microdilution method relative to wild type	2008	Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11	Staphylococcus aureus PBP4 is essential for beta-lactam resistance in community-acquired methicillin-resistant strains.
AID1551298	Antibacterial activity against Methicillin-resistant Staphylococcus aureus CCARM 3506 assessed as reduction in bacterial cell growth incubated for 24 hrs by ELISA	2019	European journal of medicinal chemistry, Jun-15, Volume: 172	Synthesis and biological evaluation of tryptophan-derived rhodanine derivatives as PTP1B inhibitors and anti-bacterial agents.
AID1294718	Bactericidal activity against methicillin-resistant Staphylococcus aureus isolate 1a assessed as reduction in colony counts at 32 ug/ml after 16 hrs by pour plate method (Rvb = 12.50 +/- 0.291 log10CFU/ml)	2016	European journal of medicinal chemistry, Jun-10, Volume: 115	Anti-methicillin resistant Staphylococcus aureus activity, synergism with oxacillin and molecular docking studies of metronidazole-triazole hybrids.
AID556039	Antimicrobial activity against erythromycin-, tetracycline resistant and yabJ-spoVG operon deficient Staphylococcus aureus COL by broth microdilution method	2009	Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5	Functional characterization of the sigmaB-dependent yabJ-spoVG operon in Staphylococcus aureus: role in methicillin and glycopeptide resistance.
AID276286	Antibacterial activity against vancomycin-resistant Staphylococcus aureus 20622 at 256 ug/ml	2006	Bioorganic & medicinal chemistry letters, Nov-15, Volume: 16, Issue:22	Solid-phase synthesis and antibacterial activity of hydroxycinnamic acid amides and analogues against methicillin-resistant Staphylococcus aureus and vancomycin-resistant S. aureus.
AID1294678	Antimicrobial activity against methicillin-resistant Staphylococcus aureus isolate 24a after 24 hrs by agar plate dilution method	2016	European journal of medicinal chemistry, Jun-10, Volume: 115	Anti-methicillin resistant Staphylococcus aureus activity, synergism with oxacillin and molecular docking studies of metronidazole-triazole hybrids.
AID207778	Inhibition of growth of Staphylococcus aureus ATCC 29213.	2001	Bioorganic & medicinal chemistry letters, Jun-18, Volume: 11, Issue:12	Amidino benzimidazole inhibitors of bacterial two-component systems.
AID564228	Activity of Escherichia coli TOP10 beta-lactamase OXA-143	2009	Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12	OXA-143, a novel carbapenem-hydrolyzing class D beta-lactamase in Acinetobacter baumannii.
AID529129	Antimicrobial activity against methicillin-resistant Staphylococcus aureus COL assessed as concentration required for bacterial subpopulation growth	2008	Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8	Comparative study of the susceptibilities of major epidemic clones of methicillin-resistant Staphylococcus aureus to oxacillin and to the new broad-spectrum cephalosporin ceftobiprole.
AID718548	Antibacterial activity against Staphylococcus aureus KCTC 503 incubated for 24 hrs serial dilution method	2012	Bioorganic & medicinal chemistry letters, Dec-01, Volume: 22, Issue:23	Synthesis and biological evaluation of 5-aryloxypyrazole derivatives bearing a rhodanine-3-aromatic acid as potential antimicrobial agents.
AID530533	Induction of PvraSr::lacZ gene expression in Staphylococcus aureus SH1000 at 1.2 ug/ml after 2 hrs by beta-galactosidase reporter gene assay relative to untreated control	2008	Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8	Staphylococcus aureus cell wall stress stimulon gene-lacZ fusion strains: potential for use in screening for cell wall-active antimicrobials.
AID573118	Antibacterial activity against methicillin-resistant Staphylococcus aureus assessed as resistant isolates by CLSI M7-A7 broth microdilution method	2008	Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9	In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States.
AID543955	Antibacterial activity against chloramphenicol, tetracycline-resistant Staphylococcus aureus COL-S carrying SAmecA/mecI-mecR1 plasmid	2009	Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2	Reconstruction of the phenotypes of methicillin-resistant Staphylococcus aureus by replacement of the staphylococcal cassette chromosome mec with a plasmid-borne copy of Staphylococcus sciuri pbpD gene.
AID544607	Antibacterial activity against Staphylococcus aureus isolate 1326 assessed as reduction in bacterial count at 20 ug/ml after 24 hrs by time-kill assay	2008	Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11	In vitro and in vivo evaluations of oxacillin efficiency against mecA-positive oxacillin-susceptible Staphylococcus aureus.
AID1559381	Antibacterial activity against Pseudomonas aeruginosa Ps296 AmpC/VIM-2/TEM-1 after 16 to 20 hrs by CLSI-based microbroth dilution method	2020	Journal of medicinal chemistry, 03-26, Volume: 63, Issue:6	Discovery of Taniborbactam (VNRX-5133): A Broad-Spectrum Serine- and Metallo-β-lactamase Inhibitor for Carbapenem-Resistant Bacterial Infections.
AID432814	Antimicrobial activity against SCCmec type 1 methicillin-resistant Staphylococcus aureus COL E2125 expressing symporter gene smr1 at 42 degC incubated for 24 hrs by E-test	2008	Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2	Role of a sodium-dependent symporter homologue in the thermosensitivity of beta-lactam antibiotic resistance and cell wall composition in Staphylococcus aureus.
AID396026	Antibacterial activity against drug-resistant Enterobacter cloacae EcDC64 isolate expressing AcrAB-TolC efflux pump by Etest	2007	Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9	Cloning, nucleotide sequencing, and analysis of the AcrAB-TolC efflux pump of Enterobacter cloacae and determination of its involvement in antibiotic resistance in a clinical isolate.
AID405471	Antibacterial activity against methicillin-resistant Staphylococcus aureus 2884	2007	Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7	Identification and phenotypic characterization of a beta-lactam-dependent, methicillin-resistant Staphylococcus aureus strain.
AID560511	Antimicrobial activity against SCCmec type III vancomycin-intermediate Staphylococcus aureus isolate b5k3578 by agar dilution method	2009	Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9	Prevalence and characterization of heterogeneous vancomycin-intermediate Staphylococcus aureus isolates from 14 cities in China.
AID574298	Antimicrobial activity against wild type community-acquired methicillin-resistant Staphylococcus aureus USA300 by microdilution method	2008	Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11	Staphylococcus aureus PBP4 is essential for beta-lactam resistance in community-acquired methicillin-resistant strains.
AID523268	Activity at Escherichia coli isolate HN1157 AcrAB-TolC efflux transporter	2010	Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5	Kinetic parameters of efflux of penicillins by the multidrug efflux transporter AcrAB-TolC of Escherichia coli.
AID548327	Antibacterial activity against Staphylococcus aureus QRSA CCARM 3519 after 20 hrs by twofold serial dilution technique	2010	European journal of medicinal chemistry, Dec, Volume: 45, Issue:12	Synthesis of new chalcone derivatives containing a rhodanine-3-acetic acid moiety with potential anti-bacterial activity.
AID1601850	Antibacterial activity against Pseudomonas aeruginosa CMCC 10104 measured after 24 hrs by ELISA	2019	European journal of medicinal chemistry, Mar-15, Volume: 166	Synthesis, antimicrobial and cytotoxic activities, and molecular docking studies of N-arylsulfonylindoles containing an aminoguanidine, a semicarbazide, and a thiosemicarbazide moiety.
AID545969	Antimicrobial activity against methicillin-resistant Staphylococcus aureus 16674 by broth dilution method	2010	Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8	Identification of a novel transposon (Tn6072) and a truncated staphylococcal cassette chromosome mec element in methicillin-resistant Staphylococcus aureus ST239.
AID718414	Antibacterial activity against log-phase vancomycin-sensitive Enterococcus faecalis ATCC 19433 assessed as growth inhibition after 24 hrs by broth microdilution method	2012	Bioorganic & medicinal chemistry, Dec-15, Volume: 20, Issue:24	3-Phenyl substituted 6,7-dimethoxyisoquinoline derivatives as FtsZ-targeting antibacterial agents.
AID1551300	Antibacterial activity against Quinolone-resistant Staphylococcus aureus CCARM 3519 assessed as reduction in bacterial cell growth incubated for 24 hrs by ELISA	2019	European journal of medicinal chemistry, Jun-15, Volume: 172	Synthesis and biological evaluation of tryptophan-derived rhodanine derivatives as PTP1B inhibitors and anti-bacterial agents.
AID404948	Antibacterial activity against methicillin-susceptible Staphylococcus aureus isolate assessed as susceptible resistant isolates by CLSI dilution method	2007	Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7	In vitro activities of CG400549, a novel FabI inhibitor, against recently isolated clinical staphylococcal strains in Korea.
AID475617	Antimicrobial activity against vancomycin-insensitive Staphylococcus aureus isolate 9	2010	Bioorganic & medicinal chemistry letters, Apr-01, Volume: 20, Issue:7	7-Phenylplatensimycin and 11-methyl-7-phenylplatensimycin: more potent analogs of platensimycin.
AID421760	Antibacterial activity against Staphylococcus aureus SA1199B overexpressing NorA efflux pump after 72 hrs	2009	Journal of natural products, Mar-27, Volume: 72, Issue:3	Bioactive pyridine-N-oxide disulfides from Allium stipitatum.
AID548132	Antibacterial activity against Escherichia coli 1356 after 20 hrs by twofold serial dilution technique	2010	European journal of medicinal chemistry, Dec, Volume: 45, Issue:12	Synthesis of new chalcone derivatives containing a rhodanine-3-acetic acid moiety with potential anti-bacterial activity.
AID521070	Antibacterial activity against group 2 PVL+ community-acquired methicillin-resistant Staphylococcus aureus ST 30 expressing SCCmec type IVc gene by agar dilution method	2008	Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3	Novel characteristics of community-acquired methicillin-resistant Staphylococcus aureus strains belonging to multilocus sequence type 59 in Taiwan.
AID570779	Antimicrobial activity against wild type hospital-acquired methicillin-resistant Staphylococcus aureus COL after 48 hrs by microdilution method	2008	Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11	Staphylococcus aureus PBP4 is essential for beta-lactam resistance in community-acquired methicillin-resistant strains.
AID325161	Antimicrobial activity against Haemophilus parasuis BB 1026	2007	Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6	Beta-lactam resistance in Haemophilus parasuis Is mediated by plasmid pB1000 bearing blaROB-1.
AID542612	Antimicrobial activity against Streptococcus pneumoniae R6 after 48 hrs by agar dilution method	2009	Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3	An important site in PBP2x of penicillin-resistant clinical isolates of Streptococcus pneumoniae: mutational analysis of Thr338.
AID285920	Antimicrobial activity against methicillin-resistant Staphylococcus aureus ATCC 43300 in human monocyte-derived macrophages at 0.25 ug/ml assessed as bacterial viability after 24 hrs	2007	Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4	Antimicrobial activities of daptomycin, vancomycin, and oxacillin in human monocytes and of daptomycin in combination with gentamicin and/or rifampin in human monocytes and in broth against Staphylococcus aureus.
AID524261	Antibacterial activity against Escherichia coli NKE154 harboring vector expressing acrB deletion mutant	2010	Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5	Effect of NlpE overproduction on multidrug resistance in Escherichia coli.
AID546209	Antimicrobial activity against Staphylococcus aureus 2171 by broth microdilution method	2010	Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8	Identification of the novel dfrK-carrying transposon Tn559 in a porcine methicillin-susceptible Staphylococcus aureus ST398 strain.
AID475623	Antimicrobial activity against vancomycin-resistant Enterococcus faecium isolate 15	2010	Bioorganic & medicinal chemistry letters, Apr-01, Volume: 20, Issue:7	7-Phenylplatensimycin and 11-methyl-7-phenylplatensimycin: more potent analogs of platensimycin.
AID637194	Antibacterial activity against Staphylococcus aureus RN4220 after 20 hrs by twofold serial dilution technique	2012	European journal of medicinal chemistry, Feb, Volume: 48	Synthesis of novel 1,3-diaryl pyrazole derivatives bearing rhodanine-3-fatty acid moieties as potential antibacterial agents.
AID750337	Antifungal activity against Candida albicans ATCC 10231 assessed as growth inhibition after 18 hrs by broth microdilution method	2013	European journal of medicinal chemistry, Jun, Volume: 64	Synthesis and evaluation of antimicrobial activity of hydrazones derived from 3-oxido-1H-imidazole-4-carbohydrazides.
AID560520	Antimicrobial activity against SCCmec type III vancomycin-intermediate Staphylococcus aureus isolate sh07043 by agar dilution method	2009	Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9	Prevalence and characterization of heterogeneous vancomycin-intermediate Staphylococcus aureus isolates from 14 cities in China.
AID548256	Antibacterial activity against vancomycin-susceptible Staphylococcus aureus Mu50omega expressing vraSm mutant gene after 24 hrs by Etest	2009	Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3	Contribution of vraSR and graSR point mutations to vancomycin resistance in vancomycin-intermediate Staphylococcus aureus.
AID1294667	Antimicrobial activity against methicillin-resistant Staphylococcus aureus isolate 13a after 24 hrs by agar plate dilution method	2016	European journal of medicinal chemistry, Jun-10, Volume: 115	Anti-methicillin resistant Staphylococcus aureus activity, synergism with oxacillin and molecular docking studies of metronidazole-triazole hybrids.
AID544615	Antibacterial activity against Staphylococcus aureus isolate 4666 infected in Wistar rat thigh infection model assessed as bacterial load per gram of thigh at 200 mg/kg, sc administered 2 hrs postinfection and every 6 hrs thereafter for 1 day measured aft	2008	Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11	In vitro and in vivo evaluations of oxacillin efficiency against mecA-positive oxacillin-susceptible Staphylococcus aureus.
AID1601844	Antibacterial activity against Streptococcus pneumoniae CMCC 31968 measured after 24 hrs by ELISA	2019	European journal of medicinal chemistry, Mar-15, Volume: 166	Synthesis, antimicrobial and cytotoxic activities, and molecular docking studies of N-arylsulfonylindoles containing an aminoguanidine, a semicarbazide, and a thiosemicarbazide moiety.
AID1634708	Antibacterial activity against vancomycin-intermediate/methicillin-resistant Staphylococcus aureus NRS402 assessed as bacterial growth inhibition after 24 hrs by broth dilution method	2016	Journal of natural products, Apr-22, Volume: 79, Issue:4	Domino Synthesis of Embelin Derivatives with Antibacterial Activity.
AID1294681	Antimicrobial activity against methicillin-resistant Staphylococcus aureus isolate 27a after 24 hrs by agar plate dilution method	2016	European journal of medicinal chemistry, Jun-10, Volume: 115	Anti-methicillin resistant Staphylococcus aureus activity, synergism with oxacillin and molecular docking studies of metronidazole-triazole hybrids.
AID297186	Antibacterial activity against multidrug resistant Staphylococcus aureus 49589	2007	Journal of medicinal chemistry, Aug-23, Volume: 50, Issue:17	Structure-activity relationships of phenyl-furanyl-rhodanines as inhibitors of RNA polymerase with antibacterial activity on biofilms.
AID509047	Antibacterial activity against beta-lactamase positive SCCmec type 4a methicillin-resistant Staphylococcus aureus isolate 11617 by broth microdilution method	2010	Antimicrobial agents and chemotherapy, Feb, Volume: 54, Issue:2	Effects of ceftobiprole and oxacillin on mecA expression in methicillin-resistant Staphylococcus aureus clinical isolates.
AID1501384	Inhibition of cell wall biosynthesis in Bacillus subtilis assessed as induction of large bulges formation at 1.875 ug/ml incubated for 2 hrs by FM-4-64 staining based assay	2017	European journal of medicinal chemistry, Oct-20, Volume: 139	Arylthiazole antibiotics targeting intracellular methicillin-resistant Staphylococcus aureus (MRSA) that interfere with bacterial cell wall synthesis.
AID525588	Antimicrobial activity against Macrococcus caseolyticus ATCC 51835 by agar dilution method	2010	Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4	Staphylococcal cassette chromosome mec-like element in Macrococcus caseolyticus.
AID761565	Antibacterial activity against Staphylococcus aureus ATCC 6538P by M07-A9 CLSI method	2013	Bioorganic & medicinal chemistry letters, Aug-01, Volume: 23, Issue:15	Synthesis and antimicrobial activity of imidazole and pyridine appended cholestane-based conjugates.
AID1067072	Antimicrobial activity against methicillin-resistant Staphylococcus aureus clinical isolate 3167 after 20 hrs by two-fold serial dilution technique	2014	European journal of medicinal chemistry, Mar-03, Volume: 74	Synthesis and evaluation of the antimicrobial activities of 3-((5-phenyl-1,3,4-oxadiazol-2-yl)methyl)-2-thioxothiazolidin-4-one derivatives.
AID1853615	Antibacterial activity against Staphylococcus aureus clinical isolate 1088626 assessed as inhibition of bacterial growth by CLSI protocol based broth microdilution method	2021	RSC medicinal chemistry, Oct-20, Volume: 12, Issue:10	Design, synthesis, and antibacterial activity of
AID529286	Antimicrobial activity against vancomycin-resistant Staphylococcus aureus VRS1 by Etest	2008	Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8	Comparative study of the susceptibilities of major epidemic clones of methicillin-resistant Staphylococcus aureus to oxacillin and to the new broad-spectrum cephalosporin ceftobiprole.
AID574549	Decrease in PSMalpha levels in Staphylococcus aureus USA300 at subinhibitory concentration after 24 hrs by RP-HPLC/ESI-MS	2010	Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11	Subinhibitory concentrations of protein synthesis-inhibiting antibiotics promote increased expression of the agr virulence regulator and production of phenol-soluble modulin cytolysins in community-associated methicillin-resistant Staphylococcus aureus.
AID1759656	Antimicrobial activity against against methicillin-resistant Staphylococcus aureus clinical isolate 1088888 by CLSI-based broth microdilution assay	2021	European journal of medicinal chemistry, Jul-05, Volume: 219	4-4-(Anilinomethyl)-3-[4-(trifluoromethyl)phenyl]-1H-pyrazol-1-ylbenzoic acid derivatives as potent anti-gram-positive bacterial agents.
AID405588	Increase in vraSR gene expression in methicillin-resistant Staphylococcus aureus 2884 isolate by RT-PCR	2007	Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7	Identification and phenotypic characterization of a beta-lactam-dependent, methicillin-resistant Staphylococcus aureus strain.
AID475616	Antimicrobial activity against methicillin-resistant Staphylococcus aureus isolate 8	2010	Bioorganic & medicinal chemistry letters, Apr-01, Volume: 20, Issue:7	7-Phenylplatensimycin and 11-methyl-7-phenylplatensimycin: more potent analogs of platensimycin.
AID575148	Antimicrobial activity against vancomycin-resistant Staphylococcus aureus VRS2 by broth microdilution method	2010	Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9	Inhibition of antibiotic-resistant Staphylococcus aureus by the broad-spectrum dihydrofolate reductase inhibitor RAB1.
AID1246258	Antimicrobial activity against Staphylococcus aureus ATCC 25923 incubated for 20 hrs by serial dilution broth microplate method	2015	European journal of medicinal chemistry, Aug-28, Volume: 101	Imidazolidine-4-one derivatives in the search for novel chemosensitizers of Staphylococcus aureus MRSA: synthesis, biological evaluation and molecular modeling studies.
AID1853613	Antibacterial activity against Staphylococcus aureus clinical isolate 1088060 assessed as inhibition of bacterial growth by CLSI protocol based broth microdilution method	2021	RSC medicinal chemistry, Oct-20, Volume: 12, Issue:10	Design, synthesis, and antibacterial activity of
AID559501	Antibacterial activity against non-ciprofloxacin-susceptible and methicillin-susceptible Staphylococcus aureus assessed as percent susceptible isolates by CLSI M100-S18 method	2009	Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8	Besifloxacin, a novel fluoroquinolone, has broad-spectrum in vitro activity against aerobic and anaerobic bacteria.
AID560509	Antimicrobial activity against SCCmec type III vancomycin-intermediate Staphylococcus aureus isolate b4k6307 by agar dilution method	2009	Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9	Prevalence and characterization of heterogeneous vancomycin-intermediate Staphylococcus aureus isolates from 14 cities in China.
AID1567133	Antimicrobial activity against CA-methicillin-resistant Staphylococcus aureus W45 ST59 incubated for 20 hrs by microdilution method	2019	European journal of medicinal chemistry, Sep-15, Volume: 178	Design, synthesis and biological evaluation of antimicrobial diarylimine and -amine compounds targeting the interaction between the bacterial NusB and NusE proteins.
AID534156	Antimicrobial activity against linezolid-resistant Enterococcus faecium 854 harboring G2576U mutation in peptidyl transferase centre by broth microdilution method	2008	Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12	In vitro activity of TR-700, the antibacterial moiety of the prodrug TR-701, against linezolid-resistant strains.
AID276295	Antibacterial activity against methicillin-resistant Staphylococcus aureus 20633 at 256 ug/ml	2006	Bioorganic & medicinal chemistry letters, Nov-15, Volume: 16, Issue:22	Solid-phase synthesis and antibacterial activity of hydroxycinnamic acid amides and analogues against methicillin-resistant Staphylococcus aureus and vancomycin-resistant S. aureus.
AID545960	Antimicrobial activity against methicillin-resistant Staphylococcus aureus 16677 by broth dilution method	2010	Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8	Identification of a novel transposon (Tn6072) and a truncated staphylococcal cassette chromosome mec element in methicillin-resistant Staphylococcus aureus ST239.
AID285936	Antimicrobial activity against methicillin-susceptible Staphylococcus aureus ATCC 29213 in human monocyte-derived macrophages at 2.5 ug/ml assessed as bacterial viability after 2 hrs	2007	Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4	Antimicrobial activities of daptomycin, vancomycin, and oxacillin in human monocytes and of daptomycin in combination with gentamicin and/or rifampin in human monocytes and in broth against Staphylococcus aureus.
AID571926	Antimicrobial activity against Escherichia coli K-12 3-AG300 harboring AcrB-N623S-Q624S mutant gene	2009	Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1	Site-directed mutagenesis reveals amino acid residues in the Escherichia coli RND efflux pump AcrB that confer macrolide resistance.
AID1651744	Antibacterial activity against Vancomycin resistant Enterococcus gallinarum MB111 after 24 hrs by microdilution assay	2020	Journal of natural products, 04-24, Volume: 83, Issue:4	Antibacterial and ATP Synthesis Modulating Compounds from
AID543956	Antibacterial activity against chloramphenicol, tetracycline-resistant Staphylococcus aureus COL-S carrying SSpbpD/mecI-mecR1 plasmid	2009	Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2	Reconstruction of the phenotypes of methicillin-resistant Staphylococcus aureus by replacement of the staphylococcal cassette chromosome mec with a plasmid-borne copy of Staphylococcus sciuri pbpD gene.
AID583690	Antimicrobial activity against methicillin-resistant Staphylococcus aureus N315deltaIP harboring hypothetical protein SA1826 14E mutant gene after 24 hrs by Etest method	2010	Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12	An RpoB mutation confers dual heteroresistance to daptomycin and vancomycin in Staphylococcus aureus.
AID431112	Antibacterial activity against heterogeneous vancomycin-intermediate Staphylococcus aureus Mu3 harboring intact graR gene after 24 hrs by agar dilution method	2008	Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1	Mutated response regulator graR is responsible for phenotypic conversion of Staphylococcus aureus from heterogeneous vancomycin-intermediate resistance to vancomycin-intermediate resistance.
AID1651732	Antibacterial activity against Methicillin-resistant Staphylococcus haemolyticus MB115 after 24 hrs by microdilution assay	2020	Journal of natural products, 04-24, Volume: 83, Issue:4	Antibacterial and ATP Synthesis Modulating Compounds from
AID1759643	Antimicrobial activity against vancomycin-resistant Enterococcus faecium clinical isolate 1094112 by CLSI-based broth microdilution assay	2021	European journal of medicinal chemistry, Jul-05, Volume: 219	4-4-(Anilinomethyl)-3-[4-(trifluoromethyl)phenyl]-1H-pyrazol-1-ylbenzoic acid derivatives as potent anti-gram-positive bacterial agents.
AID520292	Antimicrobial activity against Staphylococcus aureus 2549 small colony variants	2008	Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5	Activities of daptomycin and comparative antimicrobials, singly and in combination, against extracellular and intracellular Staphylococcus aureus and its stable small-colony variant in human monocyte-derived macrophages and in broth.
AID574551	Decrease in delta toxin levels in Staphylococcus aureus Sanger 252 at subinhibitory concentrations after 24 hrs by RP-HPLC/ESI- MS	2010	Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11	Subinhibitory concentrations of protein synthesis-inhibiting antibiotics promote increased expression of the agr virulence regulator and production of phenol-soluble modulin cytolysins in community-associated methicillin-resistant Staphylococcus aureus.
AID759325	Antibacterial activity against Escherichia coli CCARM 1356 after 24 hrs by broth microdilution method	2013	Bioorganic & medicinal chemistry letters, Aug-01, Volume: 23, Issue:15	Synthesis and biological evaluation of rhodanine derivatives bearing a quinoline moiety as potent antimicrobial agents.
AID584473	Antibacterial activity against mecA-negative Staphylococcus vitulinus SVMN03 by agar dilution method	2010	Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10	Origin and molecular evolution of the determinant of methicillin resistance in staphylococci.
AID508836	Induction of mecA gene expression in beta-lactamase positive SCCmec type 3 methicillin-resistant Staphylococcus aureus isolate 12597 at MIC after 1 hr by multiplex PCR method	2010	Antimicrobial agents and chemotherapy, Feb, Volume: 54, Issue:2	Effects of ceftobiprole and oxacillin on mecA expression in methicillin-resistant Staphylococcus aureus clinical isolates.
AID584467	Antibacterial activity against methicillin-resistant mecA-positive Staphylococcus vitulinus SVMP03 by agar dilution method	2010	Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10	Origin and molecular evolution of the determinant of methicillin resistance in staphylococci.
AID325155	Antimicrobial activity against Haemophilus parasuis BB 1022	2007	Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6	Beta-lactam resistance in Haemophilus parasuis Is mediated by plasmid pB1000 bearing blaROB-1.
AID584292	Antibacterial activity against methicillin-resistant mecA-positive Staphylococcus fleurettii SFMP02 by agar dilution method	2010	Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10	Origin and molecular evolution of the determinant of methicillin resistance in staphylococci.
AID276291	Antibacterial activity against methicillin-resistant Staphylococcus aureus 20628 at 256 ug/ml	2006	Bioorganic & medicinal chemistry letters, Nov-15, Volume: 16, Issue:22	Solid-phase synthesis and antibacterial activity of hydroxycinnamic acid amides and analogues against methicillin-resistant Staphylococcus aureus and vancomycin-resistant S. aureus.
AID544608	Antibacterial activity against Staphylococcus aureus isolate 1552 assessed as reduction in bacterial count at 20 ug/ml after 24 hrs by time-kill assay	2008	Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11	In vitro and in vivo evaluations of oxacillin efficiency against mecA-positive oxacillin-susceptible Staphylococcus aureus.
AID1438619	Antibacterial activity against methicillin-resistant Staphylococcus aureus Mu3 after 18 hrs by broth microdilution assay	2017	European journal of medicinal chemistry, Mar-10, Volume: 128	Synthesis, surfactant properties and antimicrobial activities of methyl glycopyranoside ethers.
AID529116	Antimicrobial activity against methicillin-resistant Staphylococcus aureus HAR24 by Etest	2008	Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8	Comparative study of the susceptibilities of major epidemic clones of methicillin-resistant Staphylococcus aureus to oxacillin and to the new broad-spectrum cephalosporin ceftobiprole.
AID285938	Antimicrobial activity against methicillin-susceptible Staphylococcus aureus ATCC 29213 in human monocyte-derived macrophages at 2.5 ug/ml assessed as bacterial viability after 24 hrs	2007	Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4	Antimicrobial activities of daptomycin, vancomycin, and oxacillin in human monocytes and of daptomycin in combination with gentamicin and/or rifampin in human monocytes and in broth against Staphylococcus aureus.
AID405615	Decrease in dihydrofolate reductase SA1259 N315 gene expression in oxacillin-dependent methicillin-resistant Staphylococcus aureus 2884D isolate at 0.5 ug/ml by microarray-based transcriptional profiling relative to control	2007	Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7	Identification and phenotypic characterization of a beta-lactam-dependent, methicillin-resistant Staphylococcus aureus strain.
AID285915	Antimicrobial activity against methicillin-resistant Staphylococcus aureus ATCC 43300	2007	Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4	Antimicrobial activities of daptomycin, vancomycin, and oxacillin in human monocytes and of daptomycin in combination with gentamicin and/or rifampin in human monocytes and in broth against Staphylococcus aureus.
AID285929	Antimicrobial activity against methicillin-resistant Staphylococcus aureus ATCC 43300 in human monocyte-derived macrophages at 5 ug/ml assessed as bacterial viability after 24 hrs	2007	Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4	Antimicrobial activities of daptomycin, vancomycin, and oxacillin in human monocytes and of daptomycin in combination with gentamicin and/or rifampin in human monocytes and in broth against Staphylococcus aureus.
AID405613	Decrease in SA0105 N315 gene expression in oxacillin-dependent methicillin-resistant Staphylococcus aureus 2884D isolate at 0.5 ug/ml by microarray-based transcriptional profiling relative to control	2007	Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7	Identification and phenotypic characterization of a beta-lactam-dependent, methicillin-resistant Staphylococcus aureus strain.
AID404951	Antibacterial activity against methicillin-resistant coagulase-negative Staphylococcus sp. assessed as percent resistant isolates by CLSI dilution method	2007	Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7	In vitro activities of CG400549, a novel FabI inhibitor, against recently isolated clinical staphylococcal strains in Korea.
AID278666	Antibacterial activity against methicillin-resistant Staphylococcus aureus isolate 5739	2007	Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1	High-level vancomycin-resistant Staphylococcus aureus isolates associated with a polymicrobial biofilm.
AID1888848	Antibacterial activity against Staphylococcus aureus K1758 measured after 24 hrs by Muller Hinton broth based MTT assay	2022	Bioorganic & medicinal chemistry, 01-15, Volume: 54	Potentiating the intracellular killing of Staphylococcus aureus by dihydroquinazoline analogues as NorA efflux pump inhibitor.
AID362543	Antibacterial activity against tetracycline-resistant Staphylococcus aureus XU212 after 18 hrs	2008	Journal of natural products, Aug, Volume: 71, Issue:8	Antibacterial cannabinoids from Cannabis sativa: a structure-activity study.
AID560512	Antimicrobial activity against SCCmec type III vancomycin-intermediate Staphylococcus aureus isolate b6k1642 by agar dilution method	2009	Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9	Prevalence and characterization of heterogeneous vancomycin-intermediate Staphylococcus aureus isolates from 14 cities in China.
AID1055336	Antibacterial activity against vancomycin-sensitive Enterococcus faecalis ATCC 29212 assessed as growth inhibition after 18 hrs by agar dilution method	2013	Journal of natural products, Nov-22, Volume: 76, Issue:11	Identification of elaiophylin derivatives from the marine-derived actinomycete Streptomyces sp. 7-145 using PCR-based screening.
AID1853606	Antibacterial activity against Enterococcus faecalis clinical isolate 1094112 assessed as inhibition of bacterial growth by CLSI protocol based broth microdilution method	2021	RSC medicinal chemistry, Oct-20, Volume: 12, Issue:10	Design, synthesis, and antibacterial activity of
AID1055324	Antibacterial activity against beta-lactamase producing Pseudomonas aeruginosa ATCC 27853 assessed as growth inhibition after 18 hrs by agar dilution method	2013	Journal of natural products, Nov-22, Volume: 76, Issue:11	Identification of elaiophylin derivatives from the marine-derived actinomycete Streptomyces sp. 7-145 using PCR-based screening.
AID574546	Antimicrobial activity against community-associated methicillin-resistant Staphylococcus aureus Sanger 252	2010	Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11	Subinhibitory concentrations of protein synthesis-inhibiting antibiotics promote increased expression of the agr virulence regulator and production of phenol-soluble modulin cytolysins in community-associated methicillin-resistant Staphylococcus aureus.
AID424617	Antibacterial activity against vancomycin-resistant Staphylococcus aureus AIS2006049 isolated from patients arm wound by broth microdilution method	2008	Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2	Vancomycin-resistant Staphylococcus aureus isolates associated with Inc18-like vanA plasmids in Michigan.
AID694207	Antibacterial activity against vancomycin-sensitive Enterococcus faecalis ATCC 19433 by CLSI broth microdilution method	2012	Bioorganic & medicinal chemistry letters, Nov-15, Volume: 22, Issue:22	Antibacterial activity of substituted dibenzo[a,g]quinolizin-7-ium derivatives.
AID750300	Bactericidal activity against Staphylococcus aureus isolate F12 derived from ulcer and furuncle after 18 hrs by broth microdilution method	2013	European journal of medicinal chemistry, Jun, Volume: 64	Synthesis and evaluation of antimicrobial activity of hydrazones derived from 3-oxido-1H-imidazole-4-carbohydrazides.
AID1567128	Antimicrobial activity against Streptococcus agalactiae ATCC 12386 incubated for 20 hrs by microdilution method	2019	European journal of medicinal chemistry, Sep-15, Volume: 178	Design, synthesis and biological evaluation of antimicrobial diarylimine and -amine compounds targeting the interaction between the bacterial NusB and NusE proteins.
AID521075	Antibacterial activity against group 4-v2 PVL negative community-acquired methicillin-resistant Staphylococcus aureus ST 59 expressing SCCmec type IVx gene by agar dilution method	2008	Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3	Novel characteristics of community-acquired methicillin-resistant Staphylococcus aureus strains belonging to multilocus sequence type 59 in Taiwan.
AID205670	Compound was tested for its antibacterial activity against MRSA (methicillin resistant) OC 2089.	1998	Bioorganic & medicinal chemistry letters, Jul-21, Volume: 8, Issue:14	Novel inhibitors of bacterial two-component systems with gram positive antibacterial activity: pharmacophore identification based on the screening hit closantel.
AID1870148	Antibacterial activity against wild type Staphylococcus aureus 4566/A assessed as reduction in microbial growth incubated for 24 hrs by microdilution assay	2022	Journal of medicinal chemistry, 07-28, Volume: 65, Issue:14	LEGO-Lipophosphonoxins: A Novel Approach in Designing Membrane Targeting Antimicrobials.
AID276288	Antibacterial activity against vancomycin-resistant Staphylococcus aureus 20624 at 256 ug/ml	2006	Bioorganic & medicinal chemistry letters, Nov-15, Volume: 16, Issue:22	Solid-phase synthesis and antibacterial activity of hydroxycinnamic acid amides and analogues against methicillin-resistant Staphylococcus aureus and vancomycin-resistant S. aureus.
AID519459	Antimicrobial activity against homotypic oxacillin resistant and vancomycin resistant Staphylococcus aureus isolate 5836V32 by broth microdilution method	2008	Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4	Spontaneous deletion of the methicillin resistance determinant, mecA, partially compensates for the fitness cost associated with high-level vancomycin resistance in Staphylococcus aureus.
AID1294715	Bactericidal activity against methicillin-resistant Staphylococcus aureus isolate 1a assessed as reduction in colony counts at 32 ug/ml after 4 hrs by pour plate method (Rvb = 6.14 +/- 0.456 log10CFU/ml)	2016	European journal of medicinal chemistry, Jun-10, Volume: 115	Anti-methicillin resistant Staphylococcus aureus activity, synergism with oxacillin and molecular docking studies of metronidazole-triazole hybrids.
AID1055326	Antibacterial activity against extended spectrum beta-lactamase producing Klebsiella pneumoniae ATCC 700603 assessed as growth inhibition after 18 hrs by agar dilution method	2013	Journal of natural products, Nov-22, Volume: 76, Issue:11	Identification of elaiophylin derivatives from the marine-derived actinomycete Streptomyces sp. 7-145 using PCR-based screening.
AID475613	Antimicrobial activity against methicillin-resistant Staphylococcus aureus isolate 5	2010	Bioorganic & medicinal chemistry letters, Apr-01, Volume: 20, Issue:7	7-Phenylplatensimycin and 11-methyl-7-phenylplatensimycin: more potent analogs of platensimycin.
AID285934	Antimicrobial activity against methicillin-susceptible Staphylococcus aureus ATCC 29213 in human monocyte-derived macrophages at 0.5 ug/ml assessed as bacterial viability after 4 hrs	2007	Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4	Antimicrobial activities of daptomycin, vancomycin, and oxacillin in human monocytes and of daptomycin in combination with gentamicin and/or rifampin in human monocytes and in broth against Staphylococcus aureus.
AID545948	Antimicrobial activity against methicillin-resistant Staphylococcus aureus 16672 by broth dilution method	2010	Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8	Identification of a novel transposon (Tn6072) and a truncated staphylococcal cassette chromosome mec element in methicillin-resistant Staphylococcus aureus ST239.
AID425653	Renal clearance in human	2009	Journal of medicinal chemistry, Aug-13, Volume: 52, Issue:15	Physicochemical determinants of human renal clearance.
AID765062	Antimicrobial activity against methicillin-resistant Staphylococcus aureus ATCC 33591 by broth microdilution method	2013	Bioorganic & medicinal chemistry letters, Sep-01, Volume: 23, Issue:17	Antibacterial activity of quinoxalines, quinazolines, and 1,5-naphthyridines.
AID1759653	Antimicrobial activity against against methicillin-sensitive Staphylococcus aureus clinical isolate 1088626 by CLSI-based broth microdilution assay	2021	European journal of medicinal chemistry, Jul-05, Volume: 219	4-4-(Anilinomethyl)-3-[4-(trifluoromethyl)phenyl]-1H-pyrazol-1-ylbenzoic acid derivatives as potent anti-gram-positive bacterial agents.
AID1294666	Antimicrobial activity against methicillin-resistant Staphylococcus aureus isolate 12a after 24 hrs by agar plate dilution method	2016	European journal of medicinal chemistry, Jun-10, Volume: 115	Anti-methicillin resistant Staphylococcus aureus activity, synergism with oxacillin and molecular docking studies of metronidazole-triazole hybrids.
AID1609395	Antibacterial activity against methicillin-resistant Staphylococcus aureus CCARM 3089 assessed as reduction in bacterial growth incubated for 72 hrs by spectrophotometry	2019	European journal of medicinal chemistry, Nov-15, Volume: 182	The design of a cell-selective fowlicidin-1-derived peptide with both antimicrobial and anti-inflammatory activities.
AID1827146	Antibacterial activity against methicillin-resistant Staphylococcus aureus COL assessed as inhibition of bacterial growth after 18 hrs in presence of oxacillin by CLSI protocol based broth microdilution assay	2022	ACS medicinal chemistry letters, Mar-10, Volume: 13, Issue:3	Identification and Evaluation of Brominated Carbazoles as a Novel Antibiotic Adjuvant Scaffold in MRSA.
AID1209730	Inhibition of mouse OAT3 expressed in CHO cells assessed as inhibition of fluorescein uptake over 20 mins	2013	Drug metabolism and disposition: the biological fate of chemicals, Apr, Volume: 41, Issue:4	Organic anion transporter 3 interacts selectively with lipophilic β-lactam antibiotics.
AID750314	Antibacterial activity against Staphylococcus aureus isolate F1 derived from ulcer and furuncle assessed as growth inhibition after 18 hrs by broth microdilution method	2013	European journal of medicinal chemistry, Jun, Volume: 64	Synthesis and evaluation of antimicrobial activity of hydrazones derived from 3-oxido-1H-imidazole-4-carbohydrazides.
AID1559380	Antibacterial activity against wild type Pseudomonas aeruginosa 27853 after 16 to 20 hrs by CLSI-based microbroth dilution method	2020	Journal of medicinal chemistry, 03-26, Volume: 63, Issue:6	Discovery of Taniborbactam (VNRX-5133): A Broad-Spectrum Serine- and Metallo-β-lactamase Inhibitor for Carbapenem-Resistant Bacterial Infections.
AID542621	Antimicrobial activity against Streptococcus pneumoniae R6 harboring wild type PBP2x, disruption in PBP1a and aad9 disruption in CiaR gene after 48 hrs by agar dilution method	2009	Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3	An important site in PBP2x of penicillin-resistant clinical isolates of Streptococcus pneumoniae: mutational analysis of Thr338.
AID529119	Antimicrobial activity against methicillin-resistant Staphylococcus aureus COL by Etest	2008	Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8	Comparative study of the susceptibilities of major epidemic clones of methicillin-resistant Staphylococcus aureus to oxacillin and to the new broad-spectrum cephalosporin ceftobiprole.
AID1230064	Antibacterial activity against methicillin-resistant Staphylococcus aureus GRE2272 assessed as inhibition of bacterial growth	2015	Bioorganic & medicinal chemistry, Jul-01, Volume: 23, Issue:13	Synthesis and antimicrobial activity of chloramphenicol-polyamine conjugates.
AID1294677	Antimicrobial activity against methicillin-resistant Staphylococcus aureus isolate 23a after 24 hrs by agar plate dilution method	2016	European journal of medicinal chemistry, Jun-10, Volume: 115	Anti-methicillin resistant Staphylococcus aureus activity, synergism with oxacillin and molecular docking studies of metronidazole-triazole hybrids.
AID521072	Antibacterial activity against group 3-v1 PVL negative community-acquired methicillin-resistant Staphylococcus aureus ST 900 expressing SCCmec type III gene by agar dilution method	2008	Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3	Novel characteristics of community-acquired methicillin-resistant Staphylococcus aureus strains belonging to multilocus sequence type 59 in Taiwan.
AID524383	Antibacterial activity against Escherichia coli NKE161 harboring deletion mutation in acrB protein, vector expressing tolC gene and plasmid expressing nlpE gene	2010	Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5	Effect of NlpE overproduction on multidrug resistance in Escherichia coli.
AID325157	Antimicrobial activity against Haemophilus parasuis BB 1024	2007	Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6	Beta-lactam resistance in Haemophilus parasuis Is mediated by plasmid pB1000 bearing blaROB-1.
AID1853610	Antibacterial activity against Enterococcus faecium clinical isolate 1088925 assessed as inhibition of bacterial growth by CLSI protocol based broth microdilution method	2021	RSC medicinal chemistry, Oct-20, Volume: 12, Issue:10	Design, synthesis, and antibacterial activity of
AID501192	Antimicrobial activity against methicillin sensitive Staphylococcus aureus 310 at 1 unit after 18 hrs by agar diffusion method	2009	Journal of natural products, Oct, Volume: 72, Issue:10	Norselic acids A-E, highly oxidized anti-infective steroids that deter mesograzer predation, from the Antarctic sponge Crella sp.
AID1242581	Antibacterial activity against methicillin-resistant Staphylococcus aureus R16 clinical isolate after 20 to 24 hrs by CLSI method	2015	ACS medicinal chemistry letters, Jul-09, Volume: 6, Issue:7	Triazole-Linked Glycolipids Enhance the Susceptibility of MRSA to β-Lactam Antibiotics.
AID424421	Antibacterial activity against Enterococcus faecalis HIP14333 isolated from patients rectum by broth microdilution method	2008	Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2	Vancomycin-resistant Staphylococcus aureus isolates associated with Inc18-like vanA plasmids in Michigan.
AID530524	Induction of Ppbp2::lacZ gene expression in Staphylococcus aureus SH1000 at 1.2 ug/ml after 2 hrs by beta-galactosidase reporter gene assay relative to untreated control	2008	Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8	Staphylococcus aureus cell wall stress stimulon gene-lacZ fusion strains: potential for use in screening for cell wall-active antimicrobials.
AID495798	Ratio of Kcat to Km of Pseudomonas fluorescens PF-1 beta-lactamase BIC-1 expressed in Escherichia coli DH10B using nitrocefin hydrolysis	2010	Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1	Novel ambler class A carbapenem-hydrolyzing beta-lactamase from a Pseudomonas fluorescens isolate from the Seine River, Paris, France.
AID545957	Antimicrobial activity against methicillin-resistant Staphylococcus aureus 16670 by broth dilution method	2010	Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8	Identification of a novel transposon (Tn6072) and a truncated staphylococcal cassette chromosome mec element in methicillin-resistant Staphylococcus aureus ST239.
AID575149	Antimicrobial activity against vancomycin-resistant Staphylococcus aureus VRS3 by broth microdilution method	2010	Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9	Inhibition of antibiotic-resistant Staphylococcus aureus by the broad-spectrum dihydrofolate reductase inhibitor RAB1.
AID524386	Antibacterial activity against Escherichia coli NKE157 harboring deletion mutation in acrB, acrD protein and plasmid expressing nlpE gene	2010	Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5	Effect of NlpE overproduction on multidrug resistance in Escherichia coli.
AID583685	Antimicrobial activity against methicillin-resistant Staphylococcus aureus N315deltaIP after 24 hrs by Etest method	2010	Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12	An RpoB mutation confers dual heteroresistance to daptomycin and vancomycin in Staphylococcus aureus.
AID556041	Antimicrobial activity against methicillin-resistant and tetracycline-sensitive Staphylococcus aureus COL mutant by broth microdilution method	2009	Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5	Functional characterization of the sigmaB-dependent yabJ-spoVG operon in Staphylococcus aureus: role in methicillin and glycopeptide resistance.
AID544606	Antibacterial activity against Staphylococcus aureus isolate 1306 assessed as reduction in bacterial count at 20 ug/ml after 24 hrs by time-kill assay	2008	Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11	In vitro and in vivo evaluations of oxacillin efficiency against mecA-positive oxacillin-susceptible Staphylococcus aureus.
AID1079937	Severe hepatitis, defined as possibly life-threatening liver failure or through clinical observations. Value is number of references indexed. [column 'MASS' in source]
AID556046	Antimicrobial activity against erythromycin-, glycopepeptide-intermediate-resistant and rsbUVW-sigB operon deficient Staphylococcus aureus PG223 by broth microdilution method	2009	Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5	Functional characterization of the sigmaB-dependent yabJ-spoVG operon in Staphylococcus aureus: role in methicillin and glycopeptide resistance.
AID1517079	Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC 19916 assessed as reduction in bacterial growth incubated for 24 hrs by serial dilution method	2019	European journal of medicinal chemistry, Dec-01, Volume: 183	Two optimized antimicrobial peptides with therapeutic potential for clinical antibiotic-resistant Staphylococcus aureus.
AID540211	Fraction unbound in human after iv administration	2008	Drug metabolism and disposition: the biological fate of chemicals, Jul, Volume: 36, Issue:7	Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
AID276300	Antibacterial activity against methicillin-resistant Staphylococcus aureus 20654 at 256 ug/ml	2006	Bioorganic & medicinal chemistry letters, Nov-15, Volume: 16, Issue:22	Solid-phase synthesis and antibacterial activity of hydroxycinnamic acid amides and analogues against methicillin-resistant Staphylococcus aureus and vancomycin-resistant S. aureus.
AID520724	Activity of Acinetobacter baumannii phenotype 2 beta-lactamase assessed per mg of protein at 100 uM	2008	Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5	Carbapenem-resistant Acinetobacter baumannii isolates from Tunisia producing the OXA-58-like carbapenem-hydrolyzing oxacillinase OXA-97.
AID1559373	Antibacterial activity against Escherichia coli J53 expressing SHV5/ AmpC/TEM-1 after 16 to 20 hrs by CLSI-based microbroth dilution method	2020	Journal of medicinal chemistry, 03-26, Volume: 63, Issue:6	Discovery of Taniborbactam (VNRX-5133): A Broad-Spectrum Serine- and Metallo-β-lactamase Inhibitor for Carbapenem-Resistant Bacterial Infections.
AID285926	Antimicrobial activity against methicillin-resistant Staphylococcus aureus ATCC 43300 in human monocyte-derived macrophages at 2.5 ug/ml assessed as bacterial viability after 24 hrs	2007	Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4	Antimicrobial activities of daptomycin, vancomycin, and oxacillin in human monocytes and of daptomycin in combination with gentamicin and/or rifampin in human monocytes and in broth against Staphylococcus aureus.
AID718546	Antibacterial activity against multidrug-resistant Staphylococcus aureus CCARM 3167 incubated for 24 hrs serial dilution method	2012	Bioorganic & medicinal chemistry letters, Dec-01, Volume: 22, Issue:23	Synthesis and biological evaluation of 5-aryloxypyrazole derivatives bearing a rhodanine-3-aromatic acid as potential antimicrobial agents.
AID545959	Antimicrobial activity against methicillin-resistant Staphylococcus aureus 16676 by broth dilution method	2010	Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8	Identification of a novel transposon (Tn6072) and a truncated staphylococcal cassette chromosome mec element in methicillin-resistant Staphylococcus aureus ST239.
AID1870145	Antibacterial activity against wild type Staphylococcus aureus 4880/C assessed as reduction in microbial growth incubated for 24 hrs by microdilution assay	2022	Journal of medicinal chemistry, 07-28, Volume: 65, Issue:14	LEGO-Lipophosphonoxins: A Novel Approach in Designing Membrane Targeting Antimicrobials.
AID1517085	Antibacterial activity against Staphylococcus aureus ATCC 25923 assessed as reduction in bacterial growth at MIC measured after 15 passages	2019	European journal of medicinal chemistry, Dec-01, Volume: 183	Two optimized antimicrobial peptides with therapeutic potential for clinical antibiotic-resistant Staphylococcus aureus.
AID402930	Antimicrobial activity against methicillin-resistant Staphylococcus aureus 8 after 24 hrs	2004	Journal of natural products, Jun, Volume: 67, Issue:6	New stilbene derivatives from Calligonum leucocladum.
AID584291	Antibacterial activity against methicillin-resistant mecA-positive Staphylococcus fleurettii SFMP01(CCUG 43834T) by agar dilution method	2010	Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10	Origin and molecular evolution of the determinant of methicillin resistance in staphylococci.
AID519455	Antimicrobial activity against oxacillin sensitive and vancomycin resistant Staphylococcus aureus isolate VP32 by broth microdilution method	2008	Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4	Spontaneous deletion of the methicillin resistance determinant, mecA, partially compensates for the fitness cost associated with high-level vancomycin resistance in Staphylococcus aureus.
AID509630	Antimicrobial activity against Staphylococcus aureus RN4220 by broth microdilution method	2010	Antimicrobial agents and chemotherapy, Feb, Volume: 54, Issue:2	Identification of a plasmid-borne resistance gene cluster comprising the resistance genes erm(T), dfrK, and tet(L) in a porcine methicillin-resistant Staphylococcus aureus ST398 strain.
AID685402	Antibacterial activity against Staphylococcus aureus KCTC 503 after 24 hrs by broth microdilution method	2012	European journal of medicinal chemistry, Oct, Volume: 56	Synthesis and antimicrobial evaluation of L-phenylalanine-derived C5-substituted rhodanine and chalcone derivatives containing thiobarbituric acid or 2-thioxo-4-thiazolidinone.
AID584470	Antibacterial activity against methicillin-resistant mecA-positive Staphylococcus vitulinus SVMP06 by agar dilution method	2010	Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10	Origin and molecular evolution of the determinant of methicillin resistance in staphylococci.
AID1055344	Antibacterial activity against methicillin-sensitive Staphylococcus aureus ATCC 29213 assessed as growth inhibition after 18 hrs by agar dilution method	2013	Journal of natural products, Nov-22, Volume: 76, Issue:11	Identification of elaiophylin derivatives from the marine-derived actinomycete Streptomyces sp. 7-145 using PCR-based screening.
AID1853612	Antibacterial activity against Enterococcus faecium clinical isolate 1091282 assessed as inhibition of bacterial growth by CLSI protocol based broth microdilution method	2021	RSC medicinal chemistry, Oct-20, Volume: 12, Issue:10	Design, synthesis, and antibacterial activity of
AID528496	Antimicrobial activity against high level levofloxacin and methicillin-resistant Staphylococcus aureus JCSC 6765 expressing gyrA Ser84Leu, norA T389C and grlA Ser80Phe/Glu84Lys mutants by broth microdilution method	2008	Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8	Postantibiotic effects and bactericidal activities of levofloxacin and gatifloxacin at concentrations simulating those of topical ophthalmic administration against fluoroquinolone-resistant and fluoroquinolone-sensitive methicillin-resistant Staphylococcu
AID544605	Effect on growth of against Staphylococcus aureus isolate 4666 assessed as highest compound concentration at which cell growth occurred measured after 48 hrs in presence of 2% NaCl	2008	Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11	In vitro and in vivo evaluations of oxacillin efficiency against mecA-positive oxacillin-susceptible Staphylococcus aureus.
AID278668	Antibacterial activity against methicillin-resistant Staphylococcus aureus isolate 2530	2007	Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1	High-level vancomycin-resistant Staphylococcus aureus isolates associated with a polymicrobial biofilm.
AID533944	Antimicrobial activity against linezolid-resistant Enterococcus faecalis 1172 harboring G2576U mutation in peptidyl transferase centre by broth microdilution method	2008	Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12	In vitro activity of TR-700, the antibacterial moiety of the prodrug TR-701, against linezolid-resistant strains.
AID326270	Activity of Escherichia coli beta-lactamase SCO1 relative to penicillin G	2007	Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6	SCO-1, a novel plasmid-mediated class A beta-lactamase with carbenicillinase characteristics from Escherichia coli.
AID548474	Antibacterial activity against vancomycin-susceptible Staphylococcus aureus Mu50omega expressing vraSm mutant gene after 48 hrs by Etest	2009	Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3	Contribution of vraSR and graSR point mutations to vancomycin resistance in vancomycin-intermediate Staphylococcus aureus.
AID276294	Antibacterial activity against methicillin-resistant Staphylococcus aureus 20632 at 256 ug/ml	2006	Bioorganic & medicinal chemistry letters, Nov-15, Volume: 16, Issue:22	Solid-phase synthesis and antibacterial activity of hydroxycinnamic acid amides and analogues against methicillin-resistant Staphylococcus aureus and vancomycin-resistant S. aureus.
AID325154	Antimicrobial activity against Haemophilus parasuis BB 1021	2007	Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6	Beta-lactam resistance in Haemophilus parasuis Is mediated by plasmid pB1000 bearing blaROB-1.
AID1055339	Antibacterial activity against thiostrepton-resistant Staphylococcus aureus ATCC 6538P assessed as growth inhibition after 18 hrs by agar dilution method	2013	Journal of natural products, Nov-22, Volume: 76, Issue:11	Identification of elaiophylin derivatives from the marine-derived actinomycete Streptomyces sp. 7-145 using PCR-based screening.
AID1853608	Antibacterial activity against Enterococcus faecium clinical isolate 1088168 assessed as inhibition of bacterial growth by CLSI protocol based broth microdilution method	2021	RSC medicinal chemistry, Oct-20, Volume: 12, Issue:10	Design, synthesis, and antibacterial activity of
AID560505	Antimicrobial activity against SCCmec type II vancomycin-intermediate Staphylococcus aureus isolate b2k4781 by agar dilution method	2009	Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9	Prevalence and characterization of heterogeneous vancomycin-intermediate Staphylococcus aureus isolates from 14 cities in China.
AID750307	Bactericidal activity against Staphylococcus aureus isolate C4 derived from naso-pharynx after 18 hrs by broth microdilution method	2013	European journal of medicinal chemistry, Jun, Volume: 64	Synthesis and evaluation of antimicrobial activity of hydrazones derived from 3-oxido-1H-imidazole-4-carbohydrazides.
AID520874	Antibacterial activity against methicillin-resistant mecA-positive Staphylococcus saprophyticus isolate TSU90 isolated from genitourinary tracts of acute cystitis patient after 24 hrs at 35 degC by agar dilution method	2008	Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6	Methicillin-resistant Staphylococcus saprophyticus isolates carrying staphylococcal cassette chromosome mec have emerged in urogenital tract infections.
AID583686	Antimicrobial activity against methicillin-resistant Staphylococcus aureus 10*3d1 harboring rpoB 621A mutation after 24 hrs by Etest method	2010	Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12	An RpoB mutation confers dual heteroresistance to daptomycin and vancomycin in Staphylococcus aureus.
AID1567114	Antimicrobial activity against Staphylococcus aureus ATCC BAA43 incubated for 20 hrs by microdilution method	2019	European journal of medicinal chemistry, Sep-15, Volume: 178	Design, synthesis and biological evaluation of antimicrobial diarylimine and -amine compounds targeting the interaction between the bacterial NusB and NusE proteins.
AID525587	Antimicrobial activity against Macrococcus caseolyticus ATCC 51834 by agar dilution method	2010	Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4	Staphylococcal cassette chromosome mec-like element in Macrococcus caseolyticus.
AID570778	Antimicrobial activity against wild type community-acquired methicillin-resistant Staphylococcus aureus USA300 after 48 hrs by microdilution method	2008	Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11	Staphylococcus aureus PBP4 is essential for beta-lactam resistance in community-acquired methicillin-resistant strains.
AID525585	Antimicrobial activity against multidrug-resistant Macrococcus caseolyticus JCSC7528 containing plasmid pMCCL2 which carries transposon containing (mecA(m)-mecR1(m)-mecI(m)-blaZ(m)) complex isolated from chicken by agar dilution method	2010	Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4	Staphylococcal cassette chromosome mec-like element in Macrococcus caseolyticus.
AID1517077	Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC 19167 assessed as reduction in bacterial growth incubated for 24 hrs by serial dilution method	2019	European journal of medicinal chemistry, Dec-01, Volume: 183	Two optimized antimicrobial peptides with therapeutic potential for clinical antibiotic-resistant Staphylococcus aureus.
AID548255	Antibacterial activity against vancomycin-susceptible Staphylococcus aureus Mu50omega expressing vraSn mutant gene after 24 hrs by Etest	2009	Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3	Contribution of vraSR and graSR point mutations to vancomycin resistance in vancomycin-intermediate Staphylococcus aureus.
AID405590	Increase in citZ gene expression in oxacillin-dependent methicillin-resistant Staphylococcus aureus 2884D isolate at 0.5 ug/ml by microarray-based transcriptional profiling relative to control	2007	Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7	Identification and phenotypic characterization of a beta-lactam-dependent, methicillin-resistant Staphylococcus aureus strain.
AID432986	Antimicrobial activity against SCCmec type 1 methicillin-resistant Staphylococcus aureus COL RUSA11 expressing symporter gene smr1 at 42 degC incubated for 24 hrs by E-test	2008	Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2	Role of a sodium-dependent symporter homologue in the thermosensitivity of beta-lactam antibiotic resistance and cell wall composition in Staphylococcus aureus.
AID509067	Induction of mecA gene expression in beta-lactamase positive SCCmec type 3 methicillin-resistant Staphylococcus aureus isolate 12662 at MIC after 1 hr by multiplex PCR method	2010	Antimicrobial agents and chemotherapy, Feb, Volume: 54, Issue:2	Effects of ceftobiprole and oxacillin on mecA expression in methicillin-resistant Staphylococcus aureus clinical isolates.
AID326271	Activity of Escherichia coli K12 beta-lactamase CARB1 relative to penicillin G	2007	Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6	SCO-1, a novel plasmid-mediated class A beta-lactamase with carbenicillinase characteristics from Escherichia coli.
AID528526	Antimicrobial activity against penicillin-resistant Streptococcus agalactiae B7 by agar dilution method	2008	Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8	First molecular characterization of group B streptococci with reduced penicillin susceptibility.
AID475611	Antimicrobial activity against methicillin-sensitive Staphylococcus aureus isolate 3	2010	Bioorganic & medicinal chemistry letters, Apr-01, Volume: 20, Issue:7	7-Phenylplatensimycin and 11-methyl-7-phenylplatensimycin: more potent analogs of platensimycin.
AID285932	Antimicrobial activity against methicillin-susceptible Staphylococcus aureus ATCC 29213 in human monocyte-derived macrophages at 0.25 ug/ml assessed as bacterial viability after 24 hrs	2007	Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4	Antimicrobial activities of daptomycin, vancomycin, and oxacillin in human monocytes and of daptomycin in combination with gentamicin and/or rifampin in human monocytes and in broth against Staphylococcus aureus.
AID432813	Antimicrobial activity against SCCmec type 1 methicillin-resistant Staphylococcus aureus COL E2125 expressing symporter gene smr1 at 37 degC incubated for 24 hrs by E-test	2008	Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2	Role of a sodium-dependent symporter homologue in the thermosensitivity of beta-lactam antibiotic resistance and cell wall composition in Staphylococcus aureus.
AID571766	Antimicrobial activity against Escherichia coli K-12 3-AG300 harboring AcrB-615-628MexB-N616 mutant gene	2009	Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1	Site-directed mutagenesis reveals amino acid residues in the Escherichia coli RND efflux pump AcrB that confer macrolide resistance.
AID564826	Antimicrobial activity against methicillin-resistant Staphylococcus aureus assessed as susceptible isolates after 24 hrs by broth microdilution method	2009	Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10	In vitro activities of panduratin A against clinical Staphylococcus strains.
AID560510	Antimicrobial activity against SCCmec type III vancomycin-intermediate Staphylococcus aureus isolate b5k3529 by agar dilution method	2009	Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9	Prevalence and characterization of heterogeneous vancomycin-intermediate Staphylococcus aureus isolates from 14 cities in China.
AID542620	Antimicrobial activity against streptomycin-resistant Streptococcus pneumoniae R6 harboring PBP2x T338G mutant gene and Janus disruption at PBP1a after 48 hrs by agar dilution method	2009	Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3	An important site in PBP2x of penicillin-resistant clinical isolates of Streptococcus pneumoniae: mutational analysis of Thr338.
AID528497	Antimicrobial activity against low level levofloxacin and methicillin-resistant Staphylococcus aureus JCSC 6766 expressing gyrA Glu84Lys and grlA Ser80Phe mutants by broth microdilution method	2008	Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8	Postantibiotic effects and bactericidal activities of levofloxacin and gatifloxacin at concentrations simulating those of topical ophthalmic administration against fluoroquinolone-resistant and fluoroquinolone-sensitive methicillin-resistant Staphylococcu
AID528525	Antimicrobial activity against penicillin-resistant Streptococcus agalactiae B6 by agar dilution method	2008	Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8	First molecular characterization of group B streptococci with reduced penicillin susceptibility.
AID278671	Antibacterial activity against methicillin-resistant Staphylococcus aureus isolate 5736	2007	Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1	High-level vancomycin-resistant Staphylococcus aureus isolates associated with a polymicrobial biofilm.
AID519463	Antimicrobial activity against oxacillin sensitive and tetracycline and vancomycin resistant Staphylococcus aureus isolate 3130V32deltamecA with mecA::tetM genotype by broth microdilution method	2008	Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4	Spontaneous deletion of the methicillin resistance determinant, mecA, partially compensates for the fitness cost associated with high-level vancomycin resistance in Staphylococcus aureus.
AID509063	Induction of mecA gene expression in beta-lactamase positive SCCmec type 2 methicillin-resistant Staphylococcus aureus isolate 11218 at MIC after 1 hr by multiplex PCR method	2010	Antimicrobial agents and chemotherapy, Feb, Volume: 54, Issue:2	Effects of ceftobiprole and oxacillin on mecA expression in methicillin-resistant Staphylococcus aureus clinical isolates.
AID571925	Antimicrobial activity against Escherichia coli K-12 3-AG300 harboring AcrB-G616N mutant gene	2009	Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1	Site-directed mutagenesis reveals amino acid residues in the Escherichia coli RND efflux pump AcrB that confer macrolide resistance.
AID1651727	Antibacterial activity against Staphylococcus saprophyticus MB41 after 24 hrs by microdilution assay	2020	Journal of natural products, 04-24, Volume: 83, Issue:4	Antibacterial and ATP Synthesis Modulating Compounds from
AID1567120	Antimicrobial activity against Streptococcus pneumoniae ATCC 49619 incubated for 20 hrs by microdilution method	2019	European journal of medicinal chemistry, Sep-15, Volume: 178	Design, synthesis and biological evaluation of antimicrobial diarylimine and -amine compounds targeting the interaction between the bacterial NusB and NusE proteins.
AID1079933	Acute liver toxicity defined via clinical observations and clear clinical-chemistry results: serum ALT or AST activity > 6 N or serum alkaline phosphatases activity > 1.7 N. This category includes cytolytic, choleostatic and mixed liver toxicity. Value is
AID544594	Antibacterial activity against Staphylococcus aureus isolate 6083 by agar dilution method	2008	Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11	In vitro and in vivo evaluations of oxacillin efficiency against mecA-positive oxacillin-susceptible Staphylococcus aureus.
AID1438620	Antibacterial activity against methicillin-resistant Staphylococcus aureus isolate HT 2004-0012 after 18 hrs by broth microdilution assay	2017	European journal of medicinal chemistry, Mar-10, Volume: 128	Synthesis, surfactant properties and antimicrobial activities of methyl glycopyranoside ethers.
AID560514	Antimicrobial activity against SCCmec type IV vancomycin-intermediate Staphylococcus aureus isolate 06b41 by agar dilution method	2009	Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9	Prevalence and characterization of heterogeneous vancomycin-intermediate Staphylococcus aureus isolates from 14 cities in China.
AID1242586	Antibacterial activity against methicillin-resistant Staphylococcus aureus R302 clinical isolate after 20 to 24 hrs by CLSI method	2015	ACS medicinal chemistry letters, Jul-09, Volume: 6, Issue:7	Triazole-Linked Glycolipids Enhance the Susceptibility of MRSA to β-Lactam Antibiotics.
AID405139	Antibacterial activity against methicillin-resistant Staphylococcus aureus isolate assessed as percent susceptible isolates by CLSI dilution method	2007	Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7	In vitro activities of CG400549, a novel FabI inhibitor, against recently isolated clinical staphylococcal strains in Korea.
AID1767659	Antibacterial activity against Staphylococcus epidermidis ATCC 12228 assessed as inhibition of bacterial growth incubated for 24 hrs by microdilution assay	2021	Bioorganic & medicinal chemistry letters, 09-01, Volume: 47	Antimicrobial, modulatory, and antibiofilm activity of tt-farnesol on bacterial and fungal strains of importance to human health.
AID718544	Antibacterial activity against quinolone-resistant Staphylococcus aureus CCARM 3505 incubated for 24 hrs serial dilution method	2012	Bioorganic & medicinal chemistry letters, Dec-01, Volume: 22, Issue:23	Synthesis and biological evaluation of 5-aryloxypyrazole derivatives bearing a rhodanine-3-aromatic acid as potential antimicrobial agents.
AID542387	Antimicrobial activity against Staphylococcus aureus RN4220	2009	Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2	Methicillin-resistant and -susceptible Staphylococcus aureus strains of clonal lineages ST398 and ST9 from swine carry the multidrug resistance gene cfr.
AID508835	Induction of mecA gene expression in beta-lactamase positive SCCmec type 1 methicillin-resistant Staphylococcus aureus isolate 12575 at MIC after 1 hr by multiplex PCR method	2010	Antimicrobial agents and chemotherapy, Feb, Volume: 54, Issue:2	Effects of ceftobiprole and oxacillin on mecA expression in methicillin-resistant Staphylococcus aureus clinical isolates.
AID524266	Antibacterial activity against Escherichia coli NKE128 harboring deletion mutation in acrB and tolC protein	2010	Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5	Effect of NlpE overproduction on multidrug resistance in Escherichia coli.
AID718545	Antibacterial activity against multidrug-resistant Staphylococcus aureus CCARM 3506 incubated for 24 hrs serial dilution method	2012	Bioorganic & medicinal chemistry letters, Dec-01, Volume: 22, Issue:23	Synthesis and biological evaluation of 5-aryloxypyrazole derivatives bearing a rhodanine-3-aromatic acid as potential antimicrobial agents.
AID573121	Antibacterial activity against coagulase-negative and oxacillin-susceptible Staphylococcus aureus assessed as resistant isolates by CLSI M7-A7 broth microdilution method	2008	Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9	In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States.
AID533928	Antimicrobial activity against linezolid-resistant Staphylococcus aureus 1652 harboring U2500A mutation in peptidyl transferase centre by broth microdilution method	2008	Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12	In vitro activity of TR-700, the antibacterial moiety of the prodrug TR-701, against linezolid-resistant strains.
AID405595	Increase in SA0229 N315 gene expression in oxacillin-dependent methicillin-resistant Staphylococcus aureus 2884D isolate at 0.5 ug/ml by microarray-based transcriptional profiling relative to control	2007	Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7	Identification and phenotypic characterization of a beta-lactam-dependent, methicillin-resistant Staphylococcus aureus strain.
AID562603	Antimicrobial activity against oxacillin-resistant Staphylococcus aureus clinical isolates assessed as resistant isolates by broth microdilution method	2009	Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11	Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates.
AID325476	Antibacterial activity against Staphylococcus aureus Mu50 assessed as inhibition of bacterial population at greater than 512 ug/ml after 48 hrs	2007	Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6	Polyamine effects on antibiotic susceptibility in bacteria.
AID685408	Antibacterial activity against quinolone-resistant Staphylococcus aureus CCARM 3519 clinical isolate after 24 hrs by broth microdilution method	2012	European journal of medicinal chemistry, Oct, Volume: 56	Synthesis and antimicrobial evaluation of L-phenylalanine-derived C5-substituted rhodanine and chalcone derivatives containing thiobarbituric acid or 2-thioxo-4-thiazolidinone.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	1209 (44.99)	18.7374
1990's	306 (11.39)	18.2507
2000's	498 (18.53)	29.6817
2010's	510 (18.98)	24.3611
2020's	164 (6.10)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	74 (2.59%)	5.53%
Reviews	65 (2.28%)	6.00%
Case Studies	246 (8.62%)	4.05%
Observational	7 (0.25%)	0.25%
Other	2,462 (86.26%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Trial	Phase	Enrollment	Study Type	Start Date	Status
Prospective Randomized Study to Compare Clinical Outcomes in Patients With Osteomyelitis Treated With Intravenous Antibiotics Versus Intravenous Antibiotics With an Early Switch to Oral Antibiotics [NCT02099240]	Early Phase 1	11 participants (Actual)	Interventional	2014-03-06	Terminated(stopped due to Not enough patient enrollment and lack of staffing)
COMPARISON OF CLINICAL EFFICACY OF COMBINATION Amoxycillin Plus Clavulanic Acid and Oxacillin Plus Ceftriaxone for HOSPITAL TREATMENT OF COMMUNITY Acquired PNEUMONIA IN CHILDREN : A Randomized Clinical Study [NCT01166932]	Phase 4	104 participants (Actual)	Interventional	2005-04-30	Completed
Postoperative Antibiotic Management Duration Following Surgery for Intravenous Drug Abuse (IVDA) Endocarditis (OPTIMAL) [NCT05156437]	Phase 4	20 participants (Anticipated)	Interventional	2022-03-16	Enrolling by invitation
Comparing Oral Versus Parenteral Antimicrobial Therapy (COPAT) Trial [NCT05977868]	Phase 4	135 participants (Anticipated)	Interventional	2023-08-04	Enrolling by invitation
Dalbavancin as an Option for Treatment of S. Aureus Bacteremia (DOTS): A Phase 2b, Multicenter, Randomized, Open-Label, Assessor-Blinded Superiority Study to Compare the Efficacy and Safety of Dalbavancin to Standard of Care Antibiotic Therapy for the Com [NCT04775953]	Phase 2	200 participants (Actual)	Interventional	2021-04-22	Active, not recruiting
A Phase 2, Randomized, Double-Blind, Parallel-Group, Multinational Trial of Intravenous Televancin (TD-6424) for Treatment of Uncomplicated Staphylococcus Aureus Bacteremia [NCT00062647]	Phase 2	60 participants (Actual)	Interventional	2003-08-31	Completed
A Multi-Center, Randomized, Open-Label, Comparative Study to Assess the Safety and Efficacy of a Treatment Algorithm to Reduce the Use of Vancomycin in Adult Patients With Blood Stream Infections Due to Staphylococci [NCT01191840]	Phase 2	509 participants (Actual)	Interventional	2011-02-28	Completed
A Phase 2 Randomized Study Investigating the Safety, Efficacy and Pharmacokinetics of Daptomycin 6 mg/kg and 8 mg/kg Versus Comparator in the Treatment of Subjects Undergoing Surgical Standard of Care for Osteomyelitis Associated With an Infected Prosthet [NCT00428844]	Phase 2	75 participants (Actual)	Interventional	2007-06-26	Completed
An Evaluation of the Safety, Efficacy and Pharmacokinetics of Daptomycin in Pediatric Subjects Aged One to Seventeen Years With Complicated Skin and Skin Structure Infections Caused by Gram-Positive Pathogens [NCT00711802]	Phase 4	396 participants (Actual)	Interventional	2008-07-23	Completed
An Open Label, Multi-center, Randomized, Comparative Phase IIIb Study to Compare Efficacy and Safety of Intravenous (i.v.) Daptomycin With That of Semi-Synthetic Penicillins (SSPs) or Vancomycin in the Treatment of Elderly Patients (Aged ≥ 65 Years) With [NCT01184872]	Phase 3	120 participants (Actual)	Interventional	2010-03-31	Completed
A Prospective, Multicenter, Randomized, Evaluator-blinded, Comparator-controlled Study to Describe the Safety and Efficacy of Daptomycin for the Treatment of Complicated Skin and Skin Structure Infections (cSSSI) and Staphylococcus Aureus Bacteremia Among [NCT01104662]	Phase 4	92 participants (Actual)	Interventional	2010-04-19	Terminated(stopped due to Cubist has reached an agreement with the FDA that enrollment in the DAP-RENSE-08-05 study can stop.)
[NCT01756924]	Phase 2	14 participants (Actual)	Interventional	2012-12-31	Terminated(stopped due to This study has been terminated; alternative study designs are being considered. Fusidic acid remains available under an Expanded Access Protocol.)
Linezolid vs. Vancomycin/Oxacillin/Dicloxacillin in the Treatment of Catheter-Related Gram-Positive Bloodstream Infections [NCT00037050]	Phase 3	739 participants (Actual)	Interventional	2002-04-30	Completed
A Phase 3, Multicenter, Double-Blind, Randomized, Comparator Controlled Trial of the Safety and Efficacy of Dalbavancin Versus Active Comparator in Pediatric Subjects With Acute Hematogenous Osteomyelitis of the Long Bones Known or Suspected to be Due to [NCT02344511]	Phase 3	0 participants (Actual)	Interventional	2016-03-31	Withdrawn
Antibiotic Profile of Pathogenic Bacteria Isolated From Postsurgical Site Infections in Public Hospitals in Northern Jordan [NCT05106803]		24 participants (Actual)	Observational	2019-08-01	Completed
A Phase 3 Multicenter, Randomized, Open-label, Clinical Trial of Telavancin Versus Standard Intravenous Therapy in the Treatment of Subjects With Staphylococcus Aureus Bacteremia Including Infective Endocarditis [NCT02208063]	Phase 3	121 participants (Actual)	Interventional	2014-12-31	Terminated(stopped due to Halted due to lack of statistical power. No safety concerns identified.)
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial	Outcome
NCT00062647 (1) [back to overview]	Clinical Response (Cure, Failure, or Indeterminate) as Determined by the Investigator Based the Presence or Absence of Clinical Signs and Symptoms Associated With Bacteremia, Metastatic Complications, or Positive Culture at the Test of Cure Evaluation
NCT00428844 (6) [back to overview]	Any Creatine Phosphokinase (CPK) Elevation > 500 Units Per Liter (U/L)
NCT00428844 (6) [back to overview]	Pharmacokinetic Parameter: Area Under the Concentration-time Curve During a Dosing Interval at Steady State (AUCss)
NCT00428844 (6) [back to overview]	Pharmacokinetic Parameter: Maximum Plasma Concentration (Cmax)
NCT00428844 (6) [back to overview]	Microbiological Response
NCT00428844 (6) [back to overview]	Overall Clinical Outcome
NCT00428844 (6) [back to overview]	Safety - Notable Laboratory Abnormalities
NCT00711802 (3) [back to overview]	Pharmacokinetics (PK): Area Under the Plasma Concentration-Time Curve for Daptomycin From 0 to the Last Sampling Time Point (AUC[0-t])
NCT00711802 (3) [back to overview]	Percentage of Participants With an Overall Therapeutic Response at Test of Cure Visit
NCT00711802 (3) [back to overview]	Percentage of Participants With Treatment-Emergent Adverse Events (TEAEs)
NCT01104662 (2) [back to overview]	Number of Participants With Treatment-emergent Creatine Phosphokinase (CPK) Elevations Through End of Therapy/Early Termination (EOT/ET)
NCT01104662 (2) [back to overview]	Overall Therapeutic Outcome at Test of Cure (TOC)/Safety Visit
NCT01184872 (5) [back to overview]	Duration of Treatment (Intravenous)
NCT01184872 (5) [back to overview]	Duration of Treatment (Intravenous and Oral)
NCT01184872 (5) [back to overview]	Number of Participants With Microbiological Response at Test-of-Cure (TOC) Visit
NCT01184872 (5) [back to overview]	Number of Patients With Adverse Events, Serious Adverse Events and Death
NCT01184872 (5) [back to overview]	Number of Patients With Clinical Success at the Test-Of-Cure (TOC) Visit
NCT01191840 (5) [back to overview]	Cure Rate
NCT01191840 (5) [back to overview]	Number of Participants That Changed From Vancomycin to Another Study Antibiotic Due to an Adverse Event
NCT01191840 (5) [back to overview]	Number of Participants With Adverse Events Leading to Study Drug Withdrawal
NCT01191840 (5) [back to overview]	Number of Participants With Serious Adverse Events
NCT01191840 (5) [back to overview]	Antibiotic Days by Treatment Group
NCT02208063 (4) [back to overview]	Investigator Clinical Response (Success or Failure) at EOT in the Microbiological All-treated (mAT) Population
NCT02208063 (4) [back to overview]	Number of Participants With a Clinical Outcome of Cure at Test of Cure (TOC)
NCT02208063 (4) [back to overview]	Number of Participants With an Investigator Clinical Outcome of Cure at TOC in the Microbiological All-treated (mAT) Population
NCT02208063 (4) [back to overview]	Number of Participants With the Development of a New Metastatic Foci of S. Aureus Infection at Test of Cure (TOC) in the Microbiological All-treated (mAT) Populations

Intervention	participants (Number)
	Cured	Failure
Standard Therapy	8	1
Telavancin	7	1

Intervention	Participants (Number)
Daptomycin 6 mg/kg	4
Daptomycin 8 mg/kg	5
Comparator	2

Intervention	µg•hr/mL (Median)
Daptomycin 6 mg/kg	499
Daptomycin 8 mg/kg	821

Intervention	µg/mL (Median)
Daptomycin 6 mg/kg	59.1
Daptomycin 8 mg/kg	92.3

Intervention	Participants (Number)
	Success	Failure	Non-evaluable
Comparator	8	6	7
Daptomycin 6 mg/kg	12	8	4
Daptomycin 8 mg/kg	12	3	8

Intervention	Participants (Number)
	Success	Failure	Nonevaluable
Comparator	8	11	2
Daptomycin 6 mg/kg	13	10	1
Daptomycin 8 mg/kg	13	8	2

Intervention	Participants (Number)
	Hematocrit (<30%, >60%)	Hemoglobin (<9,>19 g/dL)	Red Blood Cell (Female <2.5,>6.0; Male <3.0, >6.5)	White Blood Cell (<2, >20 x 10^9/L)	Platelets (<40, >450 x 10^9/L)	Albumin (<3, >6 g/dL)	Alkaline Phosphatase (>1350 U/L)	Alanine aminotransferase (>235 U/L)	Aspartate aminotransferase (>185 U/L)	Total bilirubin (>2.2 mg/dL)	Blood Urea Nitrogen (>50 mg/dL)	Creatinine (Female >2.0; Male>2.8 mg/dL)
Comparator	15	12	3	0	10	4	0	0	0	0	1	2
Daptomycin 6 mg/kg	12	10	2	1	13	7	0	0	1	0	2	1
Daptomycin 8 mg/kg	10	10	4	0	13	4	0	0	0	0	0	0

Intervention	microgramhour per milliliter (μghr/mL) (Mean)
Age Group 1: Daptomycin	318
Age Group 2: Daptomycin	NA
Age Group 3: Daptomycin	318
Age Group 4: Daptomycin	466

Intervention	percentage of participants (Number)
	Clinical success	Clinical failure	Unable to evaluate
Age Group 1: Daptomycin	95.9	0	4.1
Age Group 1: Standard of Care (SOC)	91.9	2.7	5.4
Age Group 2: Daptomycin	90.4	2.7	6.9
Age Group 2: SOC	92.1	0	7.9
Age Group 3: Daptomycin	82.7	1.2	16.1
Age Group 3: SOC	76.2	0	23.8
Age Group 4: Daptomycin	80.0	0	20.0
Age Group 4: SOC	86.7	0	13.3

Intervention	percentage of participants (Number)
	At least 1 TEAE	At least 1 drug-related TEAE	Discontinued treatment due to a TEAE
Age Group 1: Daptomycin	36.1	13.9	2.8
Age Group 1: Standard of Care (SOC)	36.8	10.5	0
Age Group 2: Daptomycin	23.3	5.5	1.4
Age Group 2: SOC	18.4	10.5	0
Age Group 3: Daptomycin	50.6	22.2	3.7
Age Group 3: SOC	38.1	21.4	14.3
Age Group 4: Daptomycin	46.7	10.0	3.3
Age Group 4: SOC	73.3	33.3	6.7

Intervention	participants (Number)
Daptomycin, Bacteremia, Severe Renal Impairment	0
Vancomycin or SSP, Bacteremia, Severe Renal Impairment	1
Daptomycin, Bacteremia, Moderate Renal Impairment	0
Vancomycin or SSP, Bacteremia, Moderate Renal Impairment	0
Daptomycin, cSSSI, Severe Renal Impairment	1
Vancomycin or SSP, cSSSI, Severe Renal Impairment	0
Daptomycin, cSSSI, Moderate Renal Impairment	0
Vancomycin or SSP, cSSSI, Moderate Renal Impairment	0

Intervention	participants (Number)
	Success	Failure	Non-evaluable
Daptomycin, Bacteremia, Moderate Renal Impairment	1	2	1
Daptomycin, Bacteremia, Severe Renal Impairment	9	2	4
Daptomycin, cSSSI, Moderate Renal Impairment	5	0	0
Daptomycin, cSSSI, Severe Renal Impairment	10	3	2
Vancomycin or SSP, Bacteremia, Moderate Renal Impairment	3	0	1
Vancomycin or SSP, Bacteremia, Severe Renal Impairment	9	1	6
Vancomycin or SSP, cSSSI, Moderate Renal Impairment	4	2	0
Vancomycin or SSP, cSSSI, Severe Renal Impairment	9	2	4

Intervention	Days (Mean)
Daptomycin	7.8
Vancomycin or Semi-Synthetic Penicillins (SSPs)	7.3

Intervention	Days (Mean)
	intravenous only	intravenous + oral
Daptomycin	7.8	8.7
Vancomycin or Semi-Synthetic Penicillins (SSPs)	7.3	9.6

Intervention	participants (Number)
	Success	Failure
Daptomycin	54	11
Vancomycin or Semi-Synthetic Penicillins (SSPs)	23	4

Intervention	participants (Number)
	Adverse Events	Serious Adverse Events	Death
Daptomycin	50	7	0
Vancomycin or Semi-Synthetic Penicillins (SSPs)	26	4	0

Intervention	participants (Number)
	Success	Failure
Daptomycin	65	8
Vancomycin or Semi-Synthetic Penicillins (SSPs)	25	5

Intervention	Participants (Count of Participants)
Standard of Care	207
Algorithm-determined Therapy	209

Intervention	Participants (Count of Participants)
Standard of Care	2
Algorithm-determined Therapy	5

Intervention	Participants (Count of Participants)
Standard of Care	1
Algorithm-determined Therapy	4

Intervention	Participants (Count of Participants)
Standard of Care	72
Algorithm-determined Therapy	83

Intervention	Days (Mean)
	PP Population	PPE Population
Algorithm-determined Therapy	7.5	4.4
Standard of Care	7.9	6.2

Intervention	Participants (Count of Participants)
	Success	Failure	Indeterminate	Missing
Standard of Care	36	15	0	1
Telavancin	28	13	5	1

Intervention	Participants (Count of Participants)
	Cure	Failure	Indeterminate
Standard of Care	27	21	4
Telavancin	22	19	6

Intervention	Participants (Count of Participants)
	Cure	Failure	Indeterminate	Missing
Standard of Care	31	19	0	2
Telavancin	26	15	3	3

Substance	Relationship Strength	Studies	Trials	Classes	Roles
ethylene glycol Ethylene Glycol: A colorless, odorless, viscous dihydroxy alcohol. It has a sweet taste, but is poisonous if ingested. Ethylene glycol is the most important glycol commercially available and is manufactured on a large scale in the United States. It is used as an antifreeze and coolant, in hydraulic fluids, and in the manufacture of low-freezing dynamites and resins.. ethanediol : Any diol that is ethane or substituted ethane carrying two hydroxy groups.. ethylene glycol : A 1,2-glycol compound produced via reaction of ethylene oxide with water.	2.15	1	0	ethanediol; glycol	metabolite; mouse metabolite; solvent; toxin
quinacrine Quinacrine: An acridine derivative formerly widely used as an antimalarial but superseded by chloroquine in recent years. It has also been used as an anthelmintic and in the treatment of giardiasis and malignant effusions. It is used in cell biological experiments as an inhibitor of phospholipase A2.. quinacrine : A member of the class of acridines that is acridine substituted by a chloro group at position 6, a methoxy group at position 2 and a [5-(diethylamino)pentan-2-yl]nitrilo group at position 9.	2.68	3	0	acridines; aromatic ether; organochlorine compound; tertiary amino compound	antimalarial; EC 1.8.1.12 (trypanothione-disulfide reductase) inhibitor
betaine glycine betaine : The amino acid betaine derived from glycine.	3.23	1	0	amino-acid betaine; glycine derivative	fundamental metabolite
chlordecone [no description available]	2.04	1	0	cyclic ketone; organochlorine compound	insecticide; persistent organic pollutant
choline [no description available]	1.95	1	0	cholines	allergen; Daphnia magna metabolite; Escherichia coli metabolite; human metabolite; mouse metabolite; neurotransmitter; nutrient; plant metabolite; Saccharomyces cerevisiae metabolite
chlorine chloride : A halide anion formed when chlorine picks up an electron to form an an anion.	2.13	1	0	halide anion; monoatomic chlorine	cofactor; Escherichia coli metabolite; human metabolite
coumarin 2H-chromen-2-one: coumarin derivative	2	1	0	coumarins	fluorescent dye; human metabolite; plant metabolite
salicylic acid Scalp: The outer covering of the calvaria. It is composed of several layers: SKIN; subcutaneous connective tissue; the occipitofrontal muscle which includes the tendinous galea aponeurotica; loose connective tissue; and the pericranium (the PERIOSTEUM of the SKULL).	2	1	0	monohydroxybenzoic acid	algal metabolite; antifungal agent; antiinfective agent; EC 1.11.1.11 (L-ascorbate peroxidase) inhibitor; keratolytic drug; plant hormone; plant metabolite
gallic acid gallate : A trihydroxybenzoate that is the conjugate base of gallic acid.	2.94	4	0	trihydroxybenzoic acid	antineoplastic agent; antioxidant; apoptosis inducer; astringent; cyclooxygenase 2 inhibitor; EC 1.13.11.33 (arachidonate 15-lipoxygenase) inhibitor; geroprotector; human xenobiotic metabolite; plant metabolite
bupropion Bupropion: A propiophenone-derived antidepressant and antismoking agent that inhibits the uptake of DOPAMINE.. bupropion : An aromatic ketone that is propiophenone carrying a tert-butylamino group at position 2 and a chloro substituent at position 3 on the phenyl ring.	3.23	1	0	aromatic ketone; monochlorobenzenes; secondary amino compound	antidepressant; environmental contaminant; xenobiotic
aminocaproic acid Aminocaproic Acid: An antifibrinolytic agent that acts by inhibiting plasminogen activators which have fibrinolytic properties.. 6-aminohexanoic acid : An epsilon-amino acid comprising hexanoic acid carrying an amino substituent at position C-6. Used to control postoperative bleeding, and to treat overdose effects of the thrombolytic agents streptokinase and tissue plasminogen activator.	4.01	4	0	amino acid zwitterion; epsilon-amino acid; omega-amino fatty acid	antifibrinolytic drug; hematologic agent; metabolite
creatine [no description available]	1.94	1	0	glycine derivative; guanidines; zwitterion	geroprotector; human metabolite; mouse metabolite; neuroprotective agent; nutraceutical
lactic acid Lactic Acid: A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent gastrointestinal fermentation. (From Stedman, 26th ed). 2-hydroxypropanoic acid : A 2-hydroxy monocarboxylic acid that is propanoic acid in which one of the alpha-hydrogens is replaced by a hydroxy group.	2.41	1	0	2-hydroxy monocarboxylic acid	algal metabolite; Daphnia magna metabolite
diacetyl butane-2,3-dione : An alpha-diketone that is butane substituted by oxo groups at positions 2 and 3. It is a metabolite produced during the malolactic fermentation.	7.08	1	0	alpha-diketone	Escherichia coli metabolite; Saccharomyces cerevisiae metabolite
5,6-dimethylbenzimidazole 5,6-dimethylbenzimidazole: RN given refers to parent cpd. 5,6-dimethylbenzimidazole : A dimethylbenzimidazole carrying methyl substituents at positions 5 and 6.	2.04	1	0	dimethylbenzimidazole	Escherichia coli metabolite; human metabolite
dimethyl sulfoxide Dimethyl Sulfoxide: A highly polar organic liquid, that is used widely as a chemical solvent. Because of its ability to penetrate biological membranes, it is used as a vehicle for topical application of pharmaceuticals. It is also used to protect tissue during CRYOPRESERVATION. Dimethyl sulfoxide shows a range of pharmacological activity including analgesia and anti-inflammation.. dimethyl sulfoxide : A 2-carbon sulfoxide in which the sulfur atom has two methyl substituents.	7.64	3	0	sulfoxide; volatile organic compound	alkylating agent; antidote; Escherichia coli metabolite; geroprotector; MRI contrast agent; non-narcotic analgesic; polar aprotic solvent; radical scavenger
formaldehyde paraform: polymerized formaldehyde; RN given refers to parent cpd; used in root canal therapy	1.94	1	0	aldehyde; one-carbon compound	allergen; carcinogenic agent; disinfectant; EC 3.5.1.4 (amidase) inhibitor; environmental contaminant; Escherichia coli metabolite; mouse metabolite; Saccharomyces cerevisiae metabolite
hexachlorocyclohexane Lindane: An organochlorine insecticide made up of greater than 99% gamma-Hexachlorocyclohexane. It has been used as a pediculicide and scabicide, and shown to cause cancer.. beta-hexachlorocyclohexane : The beta-isomer of hexachlorocyclohexane.	2.04	1	0	chlorocyclohexane
glycine [no description available]	1.94	1	0	alpha-amino acid; amino acid zwitterion; proteinogenic amino acid; serine family amino acid	EC 2.1.2.1 (glycine hydroxymethyltransferase) inhibitor; fundamental metabolite; hepatoprotective agent; micronutrient; neurotransmitter; NMDA receptor agonist; nutraceutical
glycerol Moon: The natural satellite of the planet Earth. It includes the lunar cycles or phases, the lunar month, lunar landscapes, geography, and soil.	1.95	1	0	alditol; triol	algal metabolite; detergent; Escherichia coli metabolite; geroprotector; human metabolite; mouse metabolite; osmolyte; Saccharomyces cerevisiae metabolite; solvent
hydrogen Hydrogen: The first chemical element in the periodic table with atomic symbol H, and atomic number 1. Protium (atomic weight 1) is by far the most common hydrogen isotope. Hydrogen also exists as the stable isotope DEUTERIUM (atomic weight 2) and the radioactive isotope TRITIUM (atomic weight 3). Hydrogen forms into a diatomic molecule at room temperature and appears as a highly flammable colorless and odorless gas.. dihydrogen : An elemental molecule consisting of two hydrogens joined by a single bond.	2.25	1	0	elemental hydrogen; elemental molecule; gas molecular entity	antioxidant; electron donor; food packaging gas; fuel; human metabolite
iodine Iodine: A nonmetallic element of the halogen group that is represented by the atomic symbol I, atomic number 53, and atomic weight of 126.90. It is a nutritionally essential element, especially important in thyroid hormone synthesis. In solution, it has anti-infective properties and is used topically.. diiodine : Molecule comprising two covalently bonded iodine atoms with overall zero charge..	3.33	7	0	diatomic iodine	nutrient
itaconic acid itaconic acid : A dicarboxylic acid that is methacrylic acid in which one of the methyl hydrogens is substituted by a carboxylic acid group.	2.04	1	0	dicarboxylic acid; dicarboxylic fatty acid; olefinic compound	fungal metabolite; human metabolite
methanol Methanol: A colorless, flammable liquid used in the manufacture of FORMALDEHYDE and ACETIC ACID, in chemical synthesis, antifreeze, and as a solvent. Ingestion of methanol is toxic and may cause blindness.. primary alcohol : A primary alcohol is a compound in which a hydroxy group, -OH, is attached to a saturated carbon atom which has either three hydrogen atoms attached to it or only one other carbon atom and two hydrogen atoms attached to it.. methanol : The primary alcohol that is the simplest aliphatic alcohol, comprising a methyl and an alcohol group.	1.97	1	0	alkyl alcohol; one-carbon compound; primary alcohol; volatile organic compound	amphiprotic solvent; Escherichia coli metabolite; fuel; human metabolite; mouse metabolite; Mycoplasma genitalium metabolite
nickel Nickel: A trace element with the atomic symbol Ni, atomic number 28, and atomic weight 58.69. It is a cofactor of the enzyme UREASE.. nickel ion : A nickel atom having a net electric charge.. nickel atom : Chemical element (nickel group element atom) with atomic number 28.	1.94	1	0	metal allergen; nickel group element atom	epitope; micronutrient
niacin Niacin: A water-soluble vitamin of the B complex occurring in various animal and plant tissues. It is required by the body for the formation of coenzymes NAD and NADP. It has PELLAGRA-curative, vasodilating, and antilipemic properties.. vitamin B3 : Any member of a group of vitamers that belong to the chemical structural class called pyridines that exhibit biological activity against vitamin B3 deficiency. Vitamin B3 deficiency causes a condition known as pellagra whose symptoms include depression, dermatitis and diarrhea. The vitamers include nicotinic acid and nicotinamide (and their ionized and salt forms).. nicotinic acid : A pyridinemonocarboxylic acid that is pyridine in which the hydrogen at position 3 is replaced by a carboxy group.	3.23	1	0	pyridine alkaloid; pyridinemonocarboxylic acid; vitamin B3	antidote; antilipemic drug; EC 3.5.1.19 (nicotinamidase) inhibitor; Escherichia coli metabolite; human urinary metabolite; metabolite; mouse metabolite; plant metabolite; vasodilator agent
nitrites Nitrites: Salts of nitrous acid or compounds containing the group NO2-. The inorganic nitrites of the type MNO2 (where M=metal) are all insoluble, except the alkali nitrites. The organic nitrites may be isomeric, but not identical with the corresponding nitro compounds. (Grant & Hackh's Chemical Dictionary, 5th ed)	1.96	1	0	monovalent inorganic anion; nitrogen oxoanion; reactive nitrogen species	human metabolite
1-octanol 1-Octanol: A colorless, slightly viscous liquid used as a defoaming or wetting agent. It is also used as a solvent for protective coatings, waxes, and oils, and as a raw material for plasticizers. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed). octan-1-ol : An octanol carrying the hydroxy group at position 1.	2.11	1	0	octanol; primary alcohol	antifungal agent; bacterial metabolite; fuel additive; kairomone; plant metabolite
parathion [no description available]	2.04	1	0	C-nitro compound; organic thiophosphate; organothiophosphate insecticide	acaricide; agrochemical; avicide; EC 3.1.1.7 (acetylcholinesterase) inhibitor; EC 3.1.1.8 (cholinesterase) inhibitor; mouse metabolite
pentachlorophenol PENTA: structure given in first source	2.04	1	0	aromatic fungicide; chlorophenol; organochlorine pesticide; pentachlorobenzenes	human xenobiotic metabolite
pyrazinamide pyrazinecarboxamide : A monocarboxylic acid amide resulting from the formal condensation of the carboxy group of pyrazinoic acid (pyrazine-2-carboxylic acid) with ammonia. A prodrug for pyrazinoic acid, pyrazinecarboxamide is used as part of multidrug regimens for the treatment of tuberculosis.	3.58	2	0	monocarboxylic acid amide; N-acylammonia; pyrazines	antitubercular agent; prodrug
pyridoxine 4,5-bis(hydroxymethyl)-2-methylpyridin-3-ol: structure in first source. vitamin B6 : Any member of the group of pyridines that exhibit biological activity against vitamin B6 deficiency. Vitamin B6 deficiency is associated with microcytic anemia, electroencephalographic abnormalities, dermatitis with cheilosis (scaling on the lips and cracks at the corners of the mouth) and glossitis (swollen tongue), depression and confusion, and weakened immune function. Vitamin B6 consists of the vitamers pyridoxine, pyridoxal, and pyridoxamine and their respective 5'-phosphate esters (and includes their corresponding ionized and salt forms).	3.23	1	0	hydroxymethylpyridine; methylpyridines; monohydroxypyridine; vitamin B6	cofactor; Escherichia coli metabolite; human metabolite; mouse metabolite; Saccharomyces cerevisiae metabolite
spermidine [no description available]	2.03	1	0	polyazaalkane; triamine	autophagy inducer; fundamental metabolite; geroprotector
spermine [no description available]	7.49	2	0	polyazaalkane; tetramine	antioxidant; fundamental metabolite; immunosuppressive agent
sulfuric acid sulfuric acid : A sulfur oxoacid that consists of two oxo and two hydroxy groups joined covalently to a central sulfur atom.	2	1	0	sulfur oxoacid	catalyst
taurine [no description available]	2.92	1	0	amino sulfonic acid; zwitterion	antioxidant; Escherichia coli metabolite; glycine receptor agonist; human metabolite; mouse metabolite; nutrient; radical scavenger; Saccharomyces cerevisiae metabolite
thiamine thiamine(1+) : A primary alcohol that is 1,3-thiazol-3-ium substituted by (4-amino-2-methylpyrimidin-5-yl)methyl, methyl and 2-hydroxyethyl groups at positions 3, 4 and 5, respectively.	3.23	1	0	primary alcohol; vitamin B1	Escherichia coli metabolite; human metabolite; mouse metabolite; Saccharomyces cerevisiae metabolite
uracil 2,4-dihydroxypyrimidine: a urinary biomarker for bipolar disorder	1.96	1	0	pyrimidine nucleobase; pyrimidone	allergen; Daphnia magna metabolite; Escherichia coli metabolite; human metabolite; mouse metabolite; prodrug; Saccharomyces cerevisiae metabolite
urea pseudourea: clinical use; structure. isourea : A carboximidic acid that is the imidic acid tautomer of urea, H2NC(=NH)OH, and its hydrocarbyl derivatives.	2.64	3	0	isourea; monocarboxylic acid amide; one-carbon compound	Daphnia magna metabolite; Escherichia coli metabolite; fertilizer; flour treatment agent; human metabolite; mouse metabolite; Saccharomyces cerevisiae metabolite
1-(3-chlorophenyl)piperazine 1-(3-chlorophenyl)piperazine: supposed metabolite of TRAZODONE; RN given refers to parent cpd; structure. 1-(3-chlorophenyl)piperazine : A N-arylpiperazine that is piperazine carrying a 3-chlorophenyl substituent at position 1. It is a metabolite of the antidepressant drug trazodone.	2.04	1	0	monochlorobenzenes; N-arylpiperazine	drug metabolite; environmental contaminant; serotonergic agonist; xenobiotic
1-anilino-8-naphthalenesulfonate 1-anilino-8-naphthalenesulfonate: RN given refers to parent cpd. 8-anilinonaphthalene-1-sulfonic acid : A naphthalenesulfonic acid that is naphthalene-1-sulfonic acid substituted by a phenylamino group at position 8.	1.94	1	0	aminonaphthalene; naphthalenesulfonic acid	fluorescent probe
hoe 33342 BXI-72: structure in first source	2.05	1	0	bibenzimidazole; N-methylpiperazine	fluorochrome
2,2'-dipyridyl 2,2'-Dipyridyl: A reagent used for the determination of iron.. 2,2'-bipyridine : A bipyridine in which the two pyridine moieties are linked by a bond between positions C-2 and C-2'.	2.49	2	0	bipyridine	chelator; ferroptosis inhibitor
mercaptoethanol Mercaptoethanol: A water-soluble thiol derived from hydrogen sulfide and ethanol. It is used as a reducing agent for disulfide bonds and to protect sulfhydryl groups from oxidation.	2.35	2	0	alkanethiol; primary alcohol	geroprotector
amitrole Amitrole: A non-selective post-emergence, translocated herbicide. According to the Seventh Annual Report on Carcinogens (PB95-109781, 1994) this substance may reasonably be anticipated to be a carcinogen. (From Merck Index, 12th ed) It is an irreversible inhibitor of CATALASE, and thus impairs activity of peroxisomes.. amitrole : A member of the class of triazoles that is 1H-1,2,4-triazole substituted by an amino group at position 3. Used to control annual grasses and aquatic weeds (but not on food crops because it causes cancer in laboratory animals). Its use within the EU was banned from September 2017 on the grounds of potential groundwater contamination and risks to aquatic life; there have also been concerns about its endocrine-disrupting properties.	2.04	1	0	aromatic amine; triazoles	carotenoid biosynthesis inhibitor; EC 1.11.1.6 (catalase) inhibitor; herbicide
enprofylline enprofylline : Xanthine bearing a propyl substituent at position 3. A bronchodilator, it is used for the symptomatic treatment of asthma and chronic obstructive pulmonary disease, and in the management of cerebrovascular insufficiency, sickle cell disease, and diabetic neuropathy.	2.45	2	0	oxopurine	anti-arrhythmia drug; anti-asthmatic drug; bronchodilator agent; non-steroidal anti-inflammatory drug
phenytoin [no description available]	4.18	5	0	imidazolidine-2,4-dione	anticonvulsant; drug allergen; sodium channel blocker; teratogenic agent
oxyquinoline Oxyquinoline: An antiseptic with mild fungistatic, bacteriostatic, anthelmintic, and amebicidal action. It is also used as a reagent and metal chelator, as a carrier for radio-indium for diagnostic purposes, and its halogenated derivatives are used in addition as topical anti-infective agents and oral antiamebics.. quinolin-8-ol : A monohydroxyquinoline that is quinoline substituted by a hydroxy group at position 8. Its fungicidal properties are used for the control of grey mould on vines and tomatoes.	2.05	1	0	monohydroxyquinoline	antibacterial agent; antifungal agrochemical; antiseptic drug; iron chelator
tacrine Tacrine: A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders.. tacrine : A member of the class of acridines that is 1,2,3,4-tetrahydroacridine substituted by an amino group at position 9. It is used in the treatment of Alzheimer's disease.	2.72	3	0	acridines; aromatic amine	EC 3.1.1.7 (acetylcholinesterase) inhibitor
acebutolol Acebutolol: A cardioselective beta-1 adrenergic antagonist with little effect on the bronchial receptors. The drug has stabilizing and quinidine-like effects on cardiac rhythm, as well as weak inherent sympathomimetic action.. acebutolol : An ether that is the 2-acetyl-4-(butanoylamino)phenyl ether of the primary hydroxy group of 3-(propan-2-ylamino)propane-1,2-diol.	4.24	5	0	aromatic amide; ethanolamines; ether; monocarboxylic acid amide; propanolamine; secondary amino compound	anti-arrhythmia drug; antihypertensive agent; beta-adrenergic antagonist; sympathomimetic agent
acetaminophen Acetaminophen: Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but may cause liver, blood cell, and kidney damage.. paracetamol : A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.	4.36	6	0	acetamides; phenols	antipyretic; cyclooxygenase 1 inhibitor; cyclooxygenase 2 inhibitor; cyclooxygenase 3 inhibitor; environmental contaminant; ferroptosis inducer; geroprotector; hepatotoxic agent; human blood serum metabolite; non-narcotic analgesic; non-steroidal anti-inflammatory drug; xenobiotic
acetazolamide Acetazolamide: One of the CARBONIC ANHYDRASE INHIBITORS that is sometimes effective against absence seizures. It is sometimes useful also as an adjunct in the treatment of tonic-clonic, myoclonic, and atonic seizures, particularly in women whose seizures occur or are exacerbated at specific times in the menstrual cycle. However, its usefulness is transient often because of rapid development of tolerance. Its antiepileptic effect may be due to its inhibitory effect on brain carbonic anhydrase, which leads to an increased transneuronal chloride gradient, increased chloride current, and increased inhibition. (From Smith and Reynard, Textbook of Pharmacology, 1991, p337)	4.21	5	0	monocarboxylic acid amide; sulfonamide; thiadiazoles	anticonvulsant; diuretic; EC 4.2.1.1 (carbonic anhydrase) inhibitor
acetohexamide Acetohexamide: A sulfonylurea hypoglycemic agent that is metabolized in the liver to 1-hydrohexamide.. acetohexamide : An N-sulfonylurea that is urea in which a hydrogen attached to one of the nitrogens is replaced by a p-acetylphenylsulfonyl group, while a hydrogen attached to the other nitrogen is replaced by a cyclohexyl group.	2.04	1	0	acetophenones; N-sulfonylurea	hypoglycemic agent; insulin secretagogue
acetohydroxamic acid acetohydroxamic acid: urease inhibitor. oxime : Compounds of structure R2C=NOH derived from condensation of aldehydes or ketones with hydroxylamine. Oximes from aldehydes may be called aldoximes; those from ketones may be called ketoximes.. N-hydroxyacetimidic acid : A carbohydroximic acid consisting of acetimidic acid having a hydroxy group attached to the imide nitrogen.. acetohydroxamic acid : A member of the class of acetohydroxamic acids that is acetamide in which one of the amino hydrogens has been replaced by a hydroxy group.	3.23	1	0	acetohydroxamic acids; carbohydroximic acid	algal metabolite; EC 3.5.1.5 (urease) inhibitor
alaproclate alaproclate: specific 5-hydroxytryptamine uptake inhibitors; RN given refers to (DL)-isomer	3.23	1	0	alpha-amino acid ester
albendazole [no description available]	3.23	1	0	aryl sulfide; benzimidazoles; benzimidazolylcarbamate fungicide; carbamate ester	anthelminthic drug; microtubule-destabilising agent; tubulin modulator
albuterol Albuterol: A short-acting beta-2 adrenergic agonist that is primarily used as a bronchodilator agent to treat ASTHMA. Albuterol is prepared as a racemic mixture of R(-) and S(+) stereoisomers. The stereospecific preparation of R(-) isomer of albuterol is referred to as levalbuterol.. albuterol : A member of the class of phenylethanolamines that is 4-(2-amino-1-hydroxyethyl)-2-(hydroxymethyl)phenol having a tert-butyl group attached to the nirogen atom. It acts as a beta-adrenergic agonist used in the treatment of asthma and chronic obstructive pulmonary disease (COPD).	4.24	5	0	phenols; phenylethanolamines; secondary amino compound	beta-adrenergic agonist; bronchodilator agent; environmental contaminant; xenobiotic
alendronate alendronic acid : A 1,1-bis(phosphonic acid) that is methanebis(phosphonic acid) in which the two methylene hydrogens are replaced by hydroxy and 3-aminopropyl groups.	3.23	1	0	1,1-bis(phosphonic acid); primary amino compound	bone density conservation agent; EC 2.5.1.1 (dimethylallyltranstransferase) inhibitor
alfuzosin alfuzosin: structure given in first source	3.58	2	0	monocarboxylic acid amide; quinazolines; tetrahydrofuranol	alpha-adrenergic antagonist; antihypertensive agent; antineoplastic agent
alosetron alosetron : A pyrido[4,3-b]indole compound having a 5-methyl-1H-imidazol-4-ylmethyl group at the 2-position.	3.58	2	0	imidazoles; pyridoindole	antiemetic; gastrointestinal drug; serotonergic antagonist
alprazolam Alprazolam: A triazolobenzodiazepine compound with antianxiety and sedative-hypnotic actions, that is efficacious in the treatment of PANIC DISORDERS, with or without AGORAPHOBIA, and in generalized ANXIETY DISORDERS. (From AMA Drug Evaluations Annual, 1994, p238). alprazolam : A member of the class of triazolobenzodiazepines that is 4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine carrying methyl, phenyl and chloro substituents at positions 1, 6 and 8 respectively. Alprazolam is only found in individuals that have taken this drug.	4.06	4	0	organochlorine compound; triazolobenzodiazepine	anticonvulsant; anxiolytic drug; GABA agonist; muscle relaxant; sedative; xenobiotic
alprenolol Alprenolol: One of the ADRENERGIC BETA-ANTAGONISTS used as an antihypertensive, anti-anginal, and anti-arrhythmic agent.. alprenolol : A secondary alcohol that is propan-2-ol substituted by a 2-allylphenoxy group at position 1 and an isopropylamino group at position 3. It is a beta-adrenergic antagonist used as a antihypertensive, anti-arrhythmia and a sympatholytic agent.	2.72	3	0	secondary alcohol; secondary amino compound	anti-arrhythmia drug; antihypertensive agent; beta-adrenergic antagonist; sympatholytic agent
altretamine Altretamine: A hexamethyl-2,4,6-triamine derivative of 1,3,5-triazine.	3.58	2	0	triamino-1,3,5-triazine
amantadine amant: an antiviral compound consisting of an adamantane derivative chemically linked to a water-solube polyanioic matrix; structure in first source	5.77	6	1	adamantanes; primary aliphatic amine	analgesic; antiparkinson drug; antiviral drug; dopaminergic agent; NMDA receptor antagonist; non-narcotic analgesic
ambenonium ambenonium : A symmetrical oxalamide-based bis-quaternary ammonium ion having ethyl and 2-chlorobenzyl groups attached to the nitrogens.	3.23	1	0	quaternary ammonium ion	EC 3.1.1.8 (cholinesterase) inhibitor
ametantrone ametantrone: RN given refers to parent cpd; structure	2.04	1	0
diatrizoic acid Diatrizoate: A commonly used x-ray contrast medium. As DIATRIZOATE MEGLUMINE and as Diatrizoate sodium, it is used for gastrointestinal studies, angiography, and urography.. amidotrizoic acid : A member of the class of benzoic acids that is benzoic acid having iodo substituents at the 2-, 4- and 6-positions and acetamido substituents at the 3- and 5-positions. It is used, mainly as its N-methylglucamine and sodium salts, as an X-ray contrast medium in gastrointestinal studies, angiography, and urography.	3.58	2	0	acetamides; benzoic acids; organoiodine compound	environmental contaminant; radioopaque medium; xenobiotic
amifostine anhydrous Amifostine: A phosphorothioate proposed as a radiation-protective agent. It causes splenic vasodilation and may block autonomic ganglia.. amifostine : An organic thiophosphate that is the S-phospho derivative of 2-[(3-aminopropyl)amino]ethanethiol. A prodrug for the free thiol, WR-1065, which is used as a cytoprotectant in cancer chemotherapy and radiotherapy.	3.23	1	0	diamine; organic thiophosphate	antioxidant; prodrug; radiation protective agent
aminoglutethimide Aminoglutethimide: An aromatase inhibitor that is used in the treatment of advanced BREAST CANCER.. aminoglutethimide : A dicarboximide that is a six-membered cyclic compound having ethyl and 4-aminophenyl substituents at the 3-position.	2.04	1	0	dicarboximide; piperidones; substituted aniline	adrenergic agent; anticonvulsant; antineoplastic agent; EC 1.14.14.14 (aromatase) inhibitor
p-aminohippuric acid p-Aminohippuric Acid: The glycine amide of 4-aminobenzoic acid. Its sodium salt is used as a diagnostic aid to measure effective renal plasma flow (ERPF) and excretory capacity.. p-aminohippurate : A hippurate that is the conjugate base of p-aminohippuric acid, arising from deprotonation of the carboxy group.. p-aminohippuric acid : An N-acylglycine that is the 4-amino derivative of hippuric acid; used as a diagnostic agent in the measurement of renal plasma flow.	3.23	1	0	N-acylglycine	Daphnia magna metabolite
theophylline [no description available]	4.24	5	0	dimethylxanthine	adenosine receptor antagonist; anti-asthmatic drug; anti-inflammatory agent; bronchodilator agent; drug metabolite; EC 3.1.4.* (phosphoric diester hydrolase) inhibitor; fungal metabolite; human blood serum metabolite; immunomodulator; muscle relaxant; vasodilator agent
2-aminothiazole 2-aminothiazole: RN given refers to parent cpd; structure. 1,3-thiazol-2-amine : A primary amino compound that is 1,3-thiazole substituted by an amino group at position 2.	2.04	1	0	1,3-thiazoles; primary amino compound
amiodarone Amiodarone: An antianginal and class III antiarrhythmic drug. It increases the duration of ventricular and atrial muscle action by inhibiting POTASSIUM CHANNELS and VOLTAGE-GATED SODIUM CHANNELS. There is a resulting decrease in heart rate and in vascular resistance.. amiodarone : A member of the class of 1-benzofurans that is 1-benzofuran substituted by a butyl group at position 2 and a 4-[2-(diethylamino)ethoxy]-3,5-diiodobenzoyl group at position 3. It is a cardiovascular drug used for the treatment of cardiac dysrhythmias.	4.06	4	0	1-benzofurans; aromatic ketone; organoiodine compound; tertiary amino compound	cardiovascular drug
dan 2163 [no description available]	2.05	1	0	aromatic amide; aromatic amine; benzamides; pyrrolidines; sulfone	environmental contaminant; second generation antipsychotic; xenobiotic
amitriptyline Amitriptyline: Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent the re-uptake of norepinephrine and serotonin at nerve terminals, thus potentiating the action of these neurotransmitters. Amitriptyline also appears to antagonize cholinergic and alpha-1 adrenergic responses to bioactive amines.. amitriptyline : An organic tricyclic compound that is 10,11-dihydro-5H-dibenzo[a,d][7]annulene substituted by a 3-(dimethylamino)propylidene group at position 5.	4.06	4	0	carbotricyclic compound; tertiary amine	adrenergic uptake inhibitor; antidepressant; environmental contaminant; tropomyosin-related kinase B receptor agonist; xenobiotic
amlodipine Amlodipine: A long-acting dihydropyridine calcium channel blocker. It is effective in the treatment of ANGINA PECTORIS and HYPERTENSION.. amlodipine : A fully substituted dialkyl 1,4-dihydropyridine-3,5-dicarboxylate derivative, which is used for the treatment of hypertension, chronic stable angina and confirmed or suspected vasospastic angina.	4.24	5	0	dihydropyridine; ethyl ester; methyl ester; monochlorobenzenes; primary amino compound	antihypertensive agent; calcium channel blocker; vasodilator agent
amobarbital Amobarbital: A barbiturate with hypnotic and sedative properties (but not antianxiety). Adverse effects are mainly a consequence of dose-related CNS depression and the risk of dependence with continued use is high. (From Martindale, The Extra Pharmacopoeia, 30th ed, p565). amobarbital : A member of the class of barbiturates that is pyrimidine-2,4,6(1H,3H,5H)-trione substituted by a 3-methylbutyl and an ethyl group at position 5. Amobarbital has been shown to exhibit sedative and hypnotic properties.	2	1	0	barbiturates
amoxapine Amoxapine: The N-demethylated derivative of the antipsychotic agent LOXAPINE that works by blocking the reuptake of norepinephrine, serotonin, or both; it also blocks dopamine receptors. Amoxapine is used for the treatment of depression.. amoxapine : A dibenzooxazepine compound having a chloro substituent at the 2-position and a piperazin-1-yl group at the 11-position.	3.23	1	0	dibenzooxazepine	adrenergic uptake inhibitor; antidepressant; dopaminergic antagonist; geroprotector; serotonin uptake inhibitor
amsacrine Amsacrine: An aminoacridine derivative that intercalates into DNA and is used as an antineoplastic agent.. amsacrine : A sulfonamide that is N-phenylmethanesulfonamide substituted by a methoxy group at position 3 and an acridin-9-ylamino group at position 4. It exhibits antineoplastic activity.	2.04	1	0	acridines; aromatic ether; sulfonamide	antineoplastic agent; EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor
anastrozole [no description available]	3.23	1	0	nitrile; triazoles	antineoplastic agent; EC 1.14.14.14 (aromatase) inhibitor
antipyrine Antipyrine: An analgesic and antipyretic that has been given by mouth and as ear drops. Antipyrine is often used in testing the effects of other drugs or diseases on drug-metabolizing enzymes in the liver. (From Martindale, The Extra Pharmacopoeia, 30th ed, p29). antipyrine : A pyrazolone derivative that is 1,2-dihydropyrazol-3-one substituted with methyl groups at N-1 and C-5 and with a phenyl group at N-2.	2.67	3	0	pyrazolone	antipyretic; cyclooxygenase 3 inhibitor; environmental contaminant; non-narcotic analgesic; non-steroidal anti-inflammatory drug; xenobiotic
aspirin Aspirin: The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5). acetylsalicylate : A benzoate that is the conjugate base of acetylsalicylic acid, arising from deprotonation of the carboxy group.. acetylsalicylic acid : A member of the class of benzoic acids that is salicylic acid in which the hydrogen that is attached to the phenolic hydroxy group has been replaced by an acetoxy group. A non-steroidal anti-inflammatory drug with cyclooxygenase inhibitor activity.	4.36	6	0	benzoic acids; phenyl acetates; salicylates	anticoagulant; antipyretic; cyclooxygenase 1 inhibitor; cyclooxygenase 2 inhibitor; drug allergen; EC 1.1.1.188 (prostaglandin-F synthase) inhibitor; geroprotector; non-narcotic analgesic; non-steroidal anti-inflammatory drug; plant activator; platelet aggregation inhibitor; prostaglandin antagonist; teratogenic agent
atenolol Atenolol: A cardioselective beta-1 adrenergic blocker possessing properties and potency similar to PROPRANOLOL, but without a negative inotropic effect.. atenolol : An ethanolamine compound having a (4-carbamoylmethylphenoxy)methyl group at the 1-position and an N-isopropyl substituent.	4.24	5	0	ethanolamines; monocarboxylic acid amide; propanolamine	anti-arrhythmia drug; antihypertensive agent; beta-adrenergic antagonist; environmental contaminant; sympatholytic agent; xenobiotic
azathioprine Azathioprine: An immunosuppressive agent used in combination with cyclophosphamide and hydroxychloroquine in the treatment of rheumatoid arthritis. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), this substance has been listed as a known carcinogen. (Merck Index, 11th ed). azathioprine : A thiopurine that is 6-mercaptopurine in which the mercapto hydrogen is replaced by a 1-methyl-4-nitroimidazol-5-yl group. It is a prodrug for mercaptopurine and is used as an immunosuppressant, prescribed for the treatment of inflammatory conditions and after organ transplantation and also for treatment of Crohn's didease and MS.	4.16	5	0	aryl sulfide; C-nitro compound; imidazoles; thiopurine	antimetabolite; antineoplastic agent; carcinogenic agent; DNA synthesis inhibitor; hepatotoxic agent; immunosuppressive agent; prodrug
azelastine azelastine: azeptin is azelastine hydrochloride; structure; eye drop formulation effective in relieving symptoms of allergic conjunctivitis; do not confuse with 5-loxin which is an extract of Boswellia. azelastine : A phthalazine compound having an oxo substituent at the 1-position, a 1-methylazepan-4-yl group at the 2-position and a 4-chlorobenzyl substituent at the 4-position.	2.45	2	0	monochlorobenzenes; phthalazines; tertiary amino compound	anti-allergic agent; anti-asthmatic drug; bronchodilator agent; EC 1.13.11.34 (arachidonate 5-lipoxygenase) inhibitor; H1-receptor antagonist; platelet aggregation inhibitor
azinphosmethyl Azinphosmethyl: An organothiophosphorus cholinesterase inhibitor. It has been used as an acaricide and as an insecticide.. azinphos-methyl : A member of the class of benzotriazines that is 1,2,3-benzotriazine substituted by an oxo group at position 4 and a [(dimethoxyphosphorothioyl)sulfanyl]methyl group at position 3.	2.04	1	0	benzotriazines; organic thiophosphate; organothiophosphate insecticide	agrochemical; EC 3.1.1.7 (acetylcholinesterase) inhibitor; EC 3.1.1.8 (cholinesterase) inhibitor
aztreonam Aztreonam: A monocyclic beta-lactam antibiotic originally isolated from Chromobacterium violaceum. It is resistant to beta-lactamases and is used in gram-negative infections, especially of the meninges, bladder, and kidneys. It may cause a superinfection with gram-positive organisms.. aztreonam : A synthetic monocyclic beta-lactam antibiotic (monobactam), used primarily to treat infections caused by Gram-negative bacteria. It inhibits mucopeptide synthesis in the bacterial cell wall, thereby blocking peptidoglycan crosslinking.	3.61	9	0
baclofen [no description available]	3.23	1	0	amino acid zwitterion; gamma-amino acid; monocarboxylic acid; monochlorobenzenes; primary amino compound	central nervous system depressant; GABA agonist; muscle relaxant
bendazac bendazac : A monocarboxylic acid that is glycolic acid in which the hydrogen attached to the 2-hydroxy group is replaced by a 1-benzyl-1H-indazol-3-yl group. Although it has anti-inflammatory, antinecrotic, choleretic and antilipidaemic properties and has been used for the treatment of various inflammatory skin disorders, its principal effect is to inhibit the denaturation of proteins. Its lysine salt is used in the management of cataracts.	3.23	1	0	indazoles; monocarboxylic acid	non-steroidal anti-inflammatory drug; radical scavenger
bendroflumethiazide Bendroflumethiazide: A thiazide diuretic with actions and uses similar to those of HYDROCHLOROTHIAZIDE. It has been used in the treatment of familial hyperkalemia, hypertension, edema, and urinary tract disorders. (From Martindale, The Extra Pharmacopoeia, 30th ed, p810). bendroflumethiazide : A sulfonamide consisting of 7-sulfamoyl-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide in which the hydrogen at position 6 is substituted by a trifluoromethyl group and that at position 3 is substituted by a benzyl group.	3.23	1	0	benzothiadiazine; sulfonamide	antihypertensive agent; diuretic
benzbromarone Benzbromarone: Uricosuric that acts by increasing uric acid clearance. It is used in the treatment of gout.. benzbromarone : 1-Benzofuran substituted at C-2 and C-3 by an ethyl group and a 3,5-dibromo-4-hydroxybenzoyl group respectively. An inhibitor of CYP2C9, it is used as an anti-gout medication.	3.23	1	0	1-benzofurans; aromatic ketone	uricosuric drug
benzothiazide benzothiazide: structure. benzthiazide : 7-Sulfamoyl-1,2,4-benzothiadiazine 1,1-dioxide in which the hydrogen at position 6 is substituted by chlorine and that at position 3 is substituted by a benzylsulfanylmethyl group. A diuretic, it is used to treat hypertension and edema.	2.13	1	0	benzothiadiazine; sulfonamide	antihypertensive agent; diuretic
bepridil Bepridil: A long-acting calcium-blocking agent with significant anti-anginal activity. The drug produces significant coronary vasodilation and modest peripheral effects. It has antihypertensive and selective anti-arrhythmia activities and acts as a calmodulin antagonist.. bepridil : A tertiary amine in which the substituents on nitrogen are benzyl, phenyl and 3-(2-methylpropoxy)-2-(pyrrolidin-1-yl)propyl.	2	1	0	pyrrolidines; tertiary amine	anti-arrhythmia drug; antihypertensive agent; calcium channel blocker; vasodilator agent
berberine [no description available]	7.74	3	0	alkaloid antibiotic; berberine alkaloid; botanical anti-fungal agent; organic heteropentacyclic compound	antilipemic drug; antineoplastic agent; antioxidant; EC 1.1.1.141 [15-hydroxyprostaglandin dehydrogenase (NAD(+))] inhibitor; EC 1.1.1.21 (aldehyde reductase) inhibitor; EC 1.13.11.52 (indoleamine 2,3-dioxygenase) inhibitor; EC 1.21.3.3 (reticuline oxidase) inhibitor; EC 2.1.1.116 [3'-hydroxy-N-methyl-(S)-coclaurine 4'-O-methyltransferase] inhibitor; EC 2.1.1.122 [(S)-tetrahydroprotoberberine N-methyltransferase] inhibitor; EC 2.7.11.10 (IkappaB kinase) inhibitor; EC 3.1.1.4 (phospholipase A2) inhibitor; EC 3.1.1.7 (acetylcholinesterase) inhibitor; EC 3.1.1.8 (cholinesterase) inhibitor; EC 3.1.3.48 (protein-tyrosine-phosphatase) inhibitor; EC 3.4.14.5 (dipeptidyl-peptidase IV) inhibitor; EC 3.4.21.26 (prolyl oligopeptidase) inhibitor; geroprotector; hypoglycemic agent; metabolite; potassium channel blocker
betaxolol [no description available]	4.24	5	0	propanolamine	antihypertensive agent; beta-adrenergic antagonist; sympatholytic agent
bethanechol Bethanechol: A slowly hydrolyzing muscarinic agonist with no nicotinic effects. Bethanechol is generally used to increase smooth muscle tone, as in the GI tract following abdominal surgery or in urinary retention in the absence of obstruction. It may cause hypotension, HEART RATE changes, and BRONCHIAL SPASM.. bethanechol : The carbamic acid ester of 2-methylcholine. A slowly hydrolysed muscarinic agonist with no nicotinic effects, it is used as its chloride salt to increase smooth muscle tone, as in the gastrointestinal tract following abdominal surgery, treatment of gastro-oesophageal reflux disease, and as an alternative to catheterisation in the treatment of non-obstructive urinary retention.	3.23	1	0	carbamate ester; quaternary ammonium ion	muscarinic agonist
bevantolol bevantolol: structure given in first source. bevantolol : A propanolamine that is 3-aminopropane-1,2-diol in which the hydrogen of the primary hydroxy group is substituted by 3-methylphenyl and one of the hydrogens attached to the nitrogen is substituted by 2-(3,4-dimethoxyphenyl)ethyl. A beta1 adrenoceptor antagonist, it has been shown to be as effective as other beta-blockers for the treatment of angina pectoris and hypertension.	2.72	3	0	propanolamine	anti-arrhythmia drug; antihypertensive agent; beta-adrenergic antagonist; calcium channel blocker
bicalutamide bicalutamide: approved for treatment of advanced prostate cancer. N-[4-cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluorophenyl)sulfonyl]-2-hydroxy-2-methylpropanamide : A member of the class of (trifluoromethyl)benzenes that is 4-amino-2-(trifluoromethyl)benzonitrile in which one of the amino hydrogens is substituted by a 3-[(4-fluorophenyl)sulfonyl]-2-hydroxy-2-methylpropanoyl group.. bicalutamide : A racemate comprising of equal amounts of (R)-bicalutamide and (S)-bicalutamide. It is an oral non-steroidal antiandrogen used in the treatment of prostate cancer and hirsutism.	3.23	1	0	(trifluoromethyl)benzenes; monocarboxylic acid amide; monofluorobenzenes; nitrile; sulfone; tertiary alcohol
biperiden Biperiden: A muscarinic antagonist that has effects in both the central and peripheral nervous systems. It has been used in the treatment of arteriosclerotic, idiopathic, and postencephalitic parkinsonism. It has also been used to alleviate extrapyramidal symptoms induced by phenothiazine derivatives and reserpine.. biperiden : A member of the class of piperidines that is N-propylpiperidine in which the methyl hydrogens have been replaced by hydroxy, phenyl, and 5-norbornen-2-yl groups. A muscarinic antagonist affecting both the central and peripheral nervous systems, it is used in the treatment of all forms of Parkinson's disease.	3.58	2	0	piperidines; tertiary alcohol; tertiary amino compound	antidote to sarin poisoning; antidyskinesia agent; antiparkinson drug; muscarinic antagonist; parasympatholytic
bisacodyl Bisacodyl: A diphenylmethane stimulant laxative used for the treatment of CONSTIPATION and for bowel evacuation. (From Martindale, The Extra Pharmacopoeia, 30th ed, p871)	3.23	1	0	diarylmethane
bisoprolol Bisoprolol: A cardioselective beta-1 adrenergic blocker. It is effective in the management of HYPERTENSION and ANGINA PECTORIS.	4.24	5	0	secondary alcohol; secondary amine	anti-arrhythmia drug; antihypertensive agent; beta-adrenergic antagonist; sympatholytic agent
bithionol Bithionol: Halogenated anti-infective agent that is used against trematode and cestode infestations.. bithionol : An aryl sulfide that is diphenyl sulfide in which each phenyl group is substituted at position 2 by hydroxy and at positions 3 and 5 by chlorine. A fungicide and anthelmintic, it was used in various topical drug products for the treatment of liver flukes, but withdrawn after being shown to be a potent photosensitizer with the potential to cause serious skin disorders.	2.31	1	0	aryl sulfide; bridged diphenyl antifungal drug; bridged diphenyl fungicide; dichlorobenzene; organochlorine pesticide; polyphenol	antifungal agrochemical; antiplatyhelmintic drug
bromazepam Bromazepam: One of the BENZODIAZEPINES that is used in the treatment of ANXIETY DISORDERS.	2.45	2	0	organic molecular entity
bromhexine Bromhexine: A mucolytic agent used in the treatment of respiratory disorders associated with viscid or excessive mucus. (From Martindale, The Extra Pharmacopoeia, 30th ed, p744). bromhexine : A substituted aniline that is 2,4-dibromoaniline which is substituted at position 6 by a [cyclohexyl(methyl)amino]methyl group. It is used (as the monohydrochloride salt) as a mucolytic for the treatment of respiratory disorders associated with productive cough (i.e. a cough characterised by the production of sputum).	2.04	1	0	organobromine compound; substituted aniline; tertiary amino compound	mucolytic
bromopride bromopride: RN given refers to parent cpd; structure	2.45	2	0	benzamides
brotizolam brotizolam: structure	2.42	2	0	organic molecular entity
buflomedil buflomedil: RN given refers to parent cpd; synonym LL 1656 refers to HCl; structure	2.45	2	0	aromatic ketone
bumetanide [no description available]	4.24	5	0	amino acid; benzoic acids; sulfonamide	diuretic; EC 3.6.3.49 (channel-conductance-controlling ATPase) inhibitor
bunazosin bunazosin: structure	2.04	1	0	quinazolines
bupivacaine Bupivacaine: A widely used local anesthetic agent.. 1-butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide : A piperidinecarboxamide obtained by formal condensation of the carboxy group of N-butylpipecolic acid with the amino group of 2,6-dimethylaniline.. bupivacaine : A racemate composed of equimolar amounts of dextrobupivacaine and levobupivacaine. Used (in the form of its hydrochloride hydrate) as a local anaesthetic.	2.73	3	0	aromatic amide; piperidinecarboxamide; tertiary amino compound
buspirone Buspirone: An anxiolytic agent and serotonin receptor agonist belonging to the azaspirodecanedione class of compounds. Its structure is unrelated to those of the BENZODIAZAPINES, but it has an efficacy comparable to DIAZEPAM.. buspirone : An azaspiro compound that is 8-azaspiro[4.5]decane-7,9-dione substituted at the nitrogen atom by a 4-(piperazin-1-yl)butyl group which in turn is substituted by a pyrimidin-2-yl group at the N(4) position.	3.23	1	0	azaspiro compound; N-alkylpiperazine; N-arylpiperazine; organic heteropolycyclic compound; piperidones; pyrimidines	anxiolytic drug; EC 3.4.21.26 (prolyl oligopeptidase) inhibitor; sedative; serotonergic agonist
busulfan [no description available]	4.07	4	0	methanesulfonate ester	alkylating agent; antineoplastic agent; carcinogenic agent; insect sterilant; teratogenic agent
secbutabarbital secbutabarbital: Butabarbital (a synonym for Secbutabarbital) should be distinguished from Butobarbital	3.23	1	0	barbiturates
caffeine [no description available]	4.39	6	0	purine alkaloid; trimethylxanthine	adenosine A2A receptor antagonist; adenosine receptor antagonist; adjuvant; central nervous system stimulant; diuretic; EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor; EC 3.1.4.* (phosphoric diester hydrolase) inhibitor; environmental contaminant; food additive; fungal metabolite; geroprotector; human blood serum metabolite; mouse metabolite; mutagen; plant metabolite; psychotropic drug; ryanodine receptor agonist; xenobiotic
verapamil Verapamil: A calcium channel blocker that is a class IV anti-arrhythmia agent.. verapamil : A racemate comprising equimolar amounts of dexverapamil and (S)-verapamil. An L-type calcium channel blocker of the phenylalkylamine class, it is used (particularly as the hydrochloride salt) in the treatment of hypertension, angina pectoris and cardiac arrhythmia, and as a preventive medication for migraine.. 2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile : A tertiary amino compound that is 3,4-dimethoxyphenylethylamine in which the hydrogens attached to the nitrogen are replaced by a methyl group and a 4-cyano-4-(3,4-dimethoxyphenyl)-5-methylhexyl group.	4.4	6	0	aromatic ether; nitrile; polyether; tertiary amino compound
metrizoate Metrizoic Acid: A diagnostic radiopaque that usually occurs as the sodium salt.	2.45	2	0	monocarboxylic acid	radioopaque medium
candesartan candesartan: a nonpeptide angiotensin II receptor antagonist. candesartan : A benzimidazolecarboxylic acid that is 1H-benzimidazole-7-carboxylic acid substituted by an ethoxy group at position 2 and a ({2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl}methyl) group at position 1. It is a angiotensin receptor antagonist used for the treatment of hypertension.	3.23	1	0	benzimidazolecarboxylic acid; biphenylyltetrazole	angiotensin receptor antagonist; antihypertensive agent; environmental contaminant; xenobiotic
cannabinol Cannabinol: A physiologically inactive constituent of Cannabis sativa L.	2.04	1	0	dibenzopyran
carbamazepine Carbamazepine: A dibenzazepine that acts as a sodium channel blocker. It is used as an anticonvulsant for the treatment of grand mal and psychomotor or focal SEIZURES. It may also be used in the management of BIPOLAR DISORDER, and has analgesic properties.. carbamazepine : A dibenzoazepine that is 5H-dibenzo[b,f]azepine carrying a carbamoyl substituent at the azepine nitrogen, used as an anticonvulsant.	3.79	3	0	dibenzoazepine; ureas	analgesic; anticonvulsant; antimanic drug; drug allergen; EC 3.5.1.98 (histone deacetylase) inhibitor; environmental contaminant; glutamate transporter activator; mitogen; non-narcotic analgesic; sodium channel blocker; xenobiotic
carbinoxamine carbinoxamine: Note: tradenames that start with Histex refer to more than one drug. carbinoxamine : An organochlorine compound that is 2-(4-chlorobenzyl)pyridine in which one of the benzylic hydrogens is substituted by 2-(dimethylamino)ethoxy group. It is an ethanolamine-type antihistamine, used as its maleate salt for treating hay fever, as well as mild cases of Parkinson's disease.	3.23	1	0	monochlorobenzenes; pyridines; tertiary amino compound	anti-allergic agent; antiparkinson drug; H1-receptor antagonist; muscarinic antagonist
carbazilquinone Carbazilquinone: An alkylating agent structurally similar to MITOMYCIN and found to be effective in the treatment of leukemia and various other neoplasms in mice. It causes leukemia and thrombocytopenia in almost all human patients.	2.04	1	0	organic molecular entity
carisoprodol Carisoprodol: A centrally acting skeletal muscle relaxant whose mechanism of action is not completely understood but may be related to its sedative actions. It is used as an adjunct in the symptomatic treatment of musculoskeletal conditions associated with painful muscle spasm. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1202). carisoprodol : A carbamate ester that is the mono-N-isopropyl derivative of meprobamate (which is a significant metabolite). Carisoprodol interrupts neuronal communication within the reticular formation and spinal cord, resulting in sedation and alteration in pain perception. It is used as a muscle relaxant in the symptomatic treatment of musculoskeletal conditions associated with painful muscle spasm.	3.23	1	0	carbamate ester	muscle relaxant
carmofur [no description available]	2.04	1	0	organohalogen compound; pyrimidines
carmustine Carmustine: A cell-cycle phase nonspecific alkylating antineoplastic agent. It is used in the treatment of brain tumors and various other malignant neoplasms. (From Martindale, The Extra Pharmacopoeia, 30th ed, p462) This substance may reasonably be anticipated to be a carcinogen according to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (From Merck Index, 11th ed). carmustine : A member of the class of N-nitrosoureas that is 1,3-bis(2-chloroethyl)urea in which one of the nitrogens is substituted by a nitroso group.	2.44	2	0	N-nitrosoureas; organochlorine compound	alkylating agent; antineoplastic agent
carprofen carprofen: RN given refers to cpd without isomeric designation. carprofen : Propanoic acid in which one of the methylene hydrogens is substituted by a 6-chloro-9H-carbazol-2-yl group. A non-steroidal anti-inflammatory drug, it is no longer used in human medicine but is still used for treatment of arthritis in elderly dogs.	2.41	1	0	carbazoles; organochlorine compound	EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor; non-steroidal anti-inflammatory drug; photosensitizing agent
carteolol Carteolol: A beta-adrenergic antagonist used as an anti-arrhythmia agent, an anti-angina agent, an antihypertensive agent, and an antiglaucoma agent.	2.42	2	0	quinolone; secondary alcohol	anti-arrhythmia drug; antiglaucoma drug; antihypertensive agent; beta-adrenergic antagonist; sympatholytic agent
carvedilol [no description available]	4.06	4	0	carbazoles; secondary alcohol; secondary amino compound	alpha-adrenergic antagonist; antihypertensive agent; beta-adrenergic antagonist; cardiovascular drug; vasodilator agent
carbonyl cyanide m-chlorophenyl hydrazone Carbonyl Cyanide m-Chlorophenyl Hydrazone: A proton ionophore. It is commonly used as an uncoupling agent and inhibitor of photosynthesis because of its effects on mitochondrial and chloroplast membranes.. CCCP : A member of the class of monochlorobenzenes that is benzene substituted by 2-(1,3-dinitrilopropan-2-ylidene)hydrazinyl and chloro groups at positions 1 and 3, respectively. It is a mitochondrial depolarizing agent that induces reactive oxygen species mediated cell death.	2.61	2	0	hydrazone; monochlorobenzenes; nitrile	antibacterial agent; geroprotector; ionophore
cefuroxime Cefuroxime: Broad-spectrum cephalosporin antibiotic resistant to beta-lactamase. It has been proposed for infections with gram-negative and gram-positive organisms, GONORRHEA, and HAEMOPHILUS.. cefuroxime : A 3-(carbamoyloxymethyl)cephalosporin compound having a 7-(2Z)-2-(furan-2-yl)-2-(methoxyimino)acetamido side chain.	3.78	11	0	carbamate ester; cephalosporin
celecoxib [no description available]	3.23	1	0	organofluorine compound; pyrazoles; sulfonamide; toluenes	cyclooxygenase 2 inhibitor; geroprotector; non-narcotic analgesic; non-steroidal anti-inflammatory drug
celiprolol Celiprolol: A cardioselective beta-1 adrenergic antagonist that has intrinsic sympathomimetic activity. It is used in the management of ANGINA PECTORIS and HYPERTENSION.	2.04	1	0	aromatic ketone
cefixime Cefixime: A third-generation cephalosporin antibiotic that is stable to hydrolysis by beta-lactamases.. cefixime : A third-generation cephalosporin antibiotic bearing vinyl and (2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-[(carboxymethoxy)imino]acetamido groups at positions 3 and 7, respectively, of the cephem skeleton. It is used in the treatment of gonorrhoea, tonsilitis, pharyngitis, bronchitis, and urinary tract infections.	1.96	1	0
cetirizine Cetirizine: A potent second-generation histamine H1 antagonist that is effective in the treatment of allergic rhinitis, chronic urticaria, and pollen-induced asthma. Unlike many traditional antihistamines, it does not cause drowsiness or anticholinergic side effects.. cetirizine : A member of the class of piperazines that is piperazine in which the hydrogens attached to nitrogen are replaced by a (4-chlorophenyl)(phenyl)methyl and a 2-(carboxymethoxy)ethyl group respectively.	3.23	1	0	ether; monocarboxylic acid; monochlorobenzenes; piperazines	anti-allergic agent; environmental contaminant; H1-receptor antagonist; xenobiotic
cetyl alcohol cetyl alcohol: has been used for eczema, skin irritations; RN given refers to parent cpd; structure. hexadecanol : A fatty alcohol consisting of a hydroxy function at any position of an unbranched saturated chain of sixteen carbon atoms.. hexadecan-1-ol : A long-chain primary fatty alcohol that is hexadecane substituted by a hydroxy group at position 1.	2.11	1	0	hexadecanol; long-chain primary fatty alcohol	algal metabolite; flavouring agent; human metabolite; plant metabolite
chelerythrine chelerythrine : A benzophenanthridine alkaloid isolated from the root of Zanthoxylum simulans, Chelidonium majus L., and other Papaveraceae.	2.77	3	0	benzophenanthridine alkaloid; organic cation	antibacterial agent; antineoplastic agent; EC 2.7.11.13 (protein kinase C) inhibitor
chloral hydrate [no description available]	2.04	1	0	aldehyde hydrate; ethanediol; organochlorine compound	general anaesthetic; mouse metabolite; sedative; xenobiotic
chlorambucil Chlorambucil: A nitrogen mustard alkylating agent used as antineoplastic for chronic lymphocytic leukemia, Hodgkin's disease, and others. Although it is less toxic than most other nitrogen mustards, it has been listed as a known carcinogen in the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (Merck Index, 11th ed). chlorambucil : A monocarboxylic acid that is butanoic acid substituted at position 4 by a 4-[bis(2-chloroethyl)amino]phenyl group. A chemotherapy drug that can be used in combination with the antibody obinutuzumab for the treatment of chronic lymphocytic leukemia.	4.24	5	0	aromatic amine; monocarboxylic acid; nitrogen mustard; organochlorine compound; tertiary amino compound	alkylating agent; antineoplastic agent; carcinogenic agent; drug allergen; immunosuppressive agent
chlorcyclizine chlorcyclizine: was heading 1964-94 (Prov 1964-73); CHLOROCYCLIZINE & HISTACHLORAZINE were see CHLORCYCLIZINE 1977-94; use PIPERAZINES to search CHLORCYCLIZINE 1966-94; histamine H1-blocker used both orally and topically in allergies and also for the prevention of motion sickness	3.23	1	0	diarylmethane
chlordiazepoxide Chlordiazepoxide: An anxiolytic benzodiazepine derivative with anticonvulsant, sedative, and amnesic properties. It has also been used in the symptomatic treatment of alcohol withdrawal.. chlordiazepoxide : A benzodiazepine that is 3H-1,4-benzodiazepine 4-oxide substituted by a chloro group at position 7, a phenyl group at position 5 and a methylamino group at position 2.	4.2	5	0	benzodiazepine
chlormezanone Chlormezanone: A non-benzodiazepine that is used in the management of anxiety. It has been suggested for use in the treatment of muscle spasm.. chlormezanone : A 1,3-thiazine that is 1,3-thiazinan-4-one S,S-dioxide in which a hydrogen at position 2 is substituted by a 4-chlorophenyl group and the hydrogen attached to the nitrogen is substituted by methyl. A non-benzodiazepine muscle relaxant, it was used in the management of anxiety and in the treatment of muscle spasms until being discontinued worldwide by its manufacturer in 1996, due to rare but serious cutaneous reactions.	3.23	1	0	1,3-thiazine; lactam; monochlorobenzenes; sulfone	antipsychotic agent; anxiolytic drug; muscle relaxant
chloroquine Chloroquine: The prototypical antimalarial agent with a mechanism that is not well understood. It has also been used to treat rheumatoid arthritis, systemic lupus erythematosus, and in the systemic therapy of amebic liver abscesses.. chloroquine : An aminoquinoline that is quinoline which is substituted at position 4 by a [5-(diethylamino)pentan-2-yl]amino group at at position 7 by chlorine. It is used for the treatment of malaria, hepatic amoebiasis, lupus erythematosus, light-sensitive skin eruptions, and rheumatoid arthritis.	4.24	5	0	aminoquinoline; organochlorine compound; secondary amino compound; tertiary amino compound	anticoronaviral agent; antimalarial; antirheumatic drug; autophagy inhibitor; dermatologic drug
chlorothiazide Chlorothiazide: A thiazide diuretic with actions and uses similar to those of HYDROCHLOROTHIAZIDE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p812). thiazide : Heterocyclic compound with sulfur and nitrogen in the ring.. chlorothiazide : 4H-1,2,4-benzothiadiazine 1,1-dioxide in which the hydrogen at position is substituted by chlorine and that at position 7 is substituted by a sulfonamide group. A diuretic, it is used for treatment of oedema and hypertension.	3.83	3	0	benzothiadiazine	antihypertensive agent; diuretic
chlorpheniramine Chlorpheniramine: A histamine H1 antagonist used in allergic reactions, hay fever, rhinitis, urticaria, and asthma. It has also been used in veterinary applications. One of the most widely used of the classical antihistaminics, it generally causes less drowsiness and sedation than PROMETHAZINE.. chlorphenamine : A tertiary amino compound that is propylamine which is substituted at position 3 by a pyridin-2-yl group and a p-chlorophenyl group and in which the hydrogens attached to the nitrogen are replaced by methyl groups. A histamine H1 antagonist, it is used to relieve the symptoms of hay fever, rhinitis, urticaria, and asthma.	4.06	4	0	monochlorobenzenes; pyridines; tertiary amino compound	anti-allergic agent; antidepressant; antipruritic drug; H1-receptor antagonist; histamine antagonist; serotonin uptake inhibitor
chlorpromazine Chlorpromazine: The prototypical phenothiazine antipsychotic drug. Like the other drugs in this class chlorpromazine's antipsychotic actions are thought to be due to long-term adaptation by the brain to blocking DOPAMINE RECEPTORS. Chlorpromazine has several other actions and therapeutic uses, including as an antiemetic and in the treatment of intractable hiccup.. chlorpromazine : A substituted phenothiazine in which the ring nitrogen at position 10 is attached to C-3 of an N,N-dimethylpropanamine moiety.	5.12	8	0	organochlorine compound; phenothiazines; tertiary amine	anticoronaviral agent; antiemetic; dopaminergic antagonist; EC 3.4.21.26 (prolyl oligopeptidase) inhibitor; phenothiazine antipsychotic drug
chlorpropamide Chlorpropamide: A sulfonylurea hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification. (From Martindale, The Extra Pharmacopoeia, 30th ed, p277). chlorpropamide : An N-sulfonylurea that is urea in which a hydrogen attached to one of the nitrogens is substituted by 4-chlorobenzenesulfonyl group and a hydrogen attached to the other nitrogen is substituted by propyl group. Chlorpropamide is a hypoglycaemic agent used in the treatment of type 2 (non-insulin-dependent) diabetes mellitus not responding to dietary modification.	4.24	5	0	monochlorobenzenes; N-sulfonylurea	hypoglycemic agent; insulin secretagogue
chlorthalidone Chlorthalidone: A benzenesulfonamide-phthalimidine that tautomerizes to a BENZOPHENONES form. It is considered a thiazide-like diuretic.	4.24	5	0	isoindoles; monochlorobenzenes; sulfonamide
chlorzoxazone Chlorzoxazone: A centrally acting central muscle relaxant with sedative properties. It is claimed to inhibit muscle spasm by exerting an effect primarily at the level of the spinal cord and subcortical areas of the brain. (From Martindale, The Extra Pharmacopoea, 30th ed, p1202). chlorzoxazone : A member of the class of 1,3-benzoxazoles that is 1,3-benzoxazol-2-ol in which the hydrogen atom at position 5 is substituted by chlorine. A centrally acting muscle relaxant with sedative properties, it is used for the symptomatic treatment of painful muscle spasm.	3.23	1	0	1,3-benzoxazoles; heteroaryl hydroxy compound; organochlorine compound	muscle relaxant; sedative
cifenline [no description available]	2.72	3	0	diarylmethane
cilostazol [no description available]	3.23	1	0	lactam; tetrazoles	anticoagulant; bronchodilator agent; EC 3.1.4.17 (3',5'-cyclic-nucleotide phosphodiesterase) inhibitor; fibrin modulating drug; neuroprotective agent; platelet aggregation inhibitor; vasodilator agent
cimetidine Cimetidine: A histamine congener, it competitively inhibits HISTAMINE binding to HISTAMINE H2 RECEPTORS. Cimetidine has a range of pharmacological actions. It inhibits GASTRIC ACID secretion, as well as PEPSIN and GASTRIN output.. cimetidine : A member of the class of guanidines that consists of guanidine carrying a methyl substituent at position 1, a cyano group at position 2 and a 2-{[(5-methyl-1H-imidazol-4-yl)methyl]sulfanyl}ethyl group at position 3. It is a H2-receptor antagonist that inhibits the production of acid in stomach.	4.24	5	0	aliphatic sulfide; guanidines; imidazoles; nitrile	adjuvant; analgesic; anti-ulcer drug; H2-receptor antagonist; P450 inhibitor
ciprofloxacin Ciprofloxacin: A broad-spectrum antimicrobial carboxyfluoroquinoline.. ciprofloxacin : A quinolone that is quinolin-4(1H)-one bearing cyclopropyl, carboxylic acid, fluoro and piperazin-1-yl substituents at positions 1, 3, 6 and 7, respectively.	10.15	88	3	aminoquinoline; cyclopropanes; fluoroquinolone antibiotic; N-arylpiperazine; quinolinemonocarboxylic acid; quinolone antibiotic; quinolone; zwitterion	antibacterial drug; antiinfective agent; antimicrobial agent; DNA synthesis inhibitor; EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor; environmental contaminant; topoisomerase IV inhibitor; xenobiotic
cisapride Cisapride: A substituted benzamide used for its prokinetic properties. It is used in the management of gastroesophageal reflux disease, functional dyspepsia, and other disorders associated with impaired gastrointestinal motility. (Martindale The Extra Pharmacopoeia, 31st ed). cisapride : The amide resulting from formal condensation of 4-amino-5-chloro-2-methoxybenzoic acid with cis-1-[3-(4-fluorophenoxy)propyl]-3-methoxypiperidin-4-amine. It has been used (as its monohydrate or as its tartrate) for the treatment of gastro-oesophageal reflux disease and for non-ulcer dyspepsia, but its propensity to cause cardiac arrhythmias resulted in its complete withdrawal from many countries, including the U.K., and restrictions on its use elsewhere.	2	1	0	benzamides
citalopram Citalopram: A furancarbonitrile that is one of the serotonin uptake inhibitors used as an antidepressant. The drug is also effective in reducing ethanol uptake in alcoholics and is used in depressed patients who also suffer from TARDIVE DYSKINESIA in preference to tricyclic antidepressants, which aggravate dyskinesia.. citalopram : A racemate comprising equimolar amounts of (R)-citalopram and its enantiomer, escitalopram. It is used as an antidepressant, although only escitalopram is active.. 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile : A nitrile that is 1,3-dihydro-2-benzofuran-5-carbonitrile in which one of the hydrogens at position 1 is replaced by a p-fluorophenyl group, while the other is replaced by a 3-(dimethylamino)propyl group.	4.06	4	0	2-benzofurans; cyclic ether; nitrile; organofluorine compound; tertiary amino compound
clenbuterol Clenbuterol: A substituted phenylaminoethanol that has beta-2 adrenomimetic properties at very low doses. It is used as a bronchodilator in asthma.. clenbuterol : A substituted aniline that is 2,6-dichloroaniline in which the hydrogen at position 4 has been replaced by a 2-(tert-butylamino)-1-hydroxyethyl group.	2.04	1	0	amino alcohol; dichlorobenzene; ethanolamines; primary arylamine; secondary amino compound; substituted aniline	beta-adrenergic agonist; bronchodilator agent; sympathomimetic agent
clioquinol Clioquinol: A potentially neurotoxic 8-hydroxyquinoline derivative long used as a topical anti-infective, intestinal antiamebic, and vaginal trichomonacide. The oral preparation has been shown to cause subacute myelo-optic neuropathy and has been banned worldwide.. 5-chloro-7-iodoquinolin-8-ol : A monohydroxyquinoline that is quinolin-8-ol in which the hydrogens at positions 5 and 7 are replaced by chlorine and iodine, respectively. It has antibacterial and atifungal properties, and is used in creams for the treatment of skin infections. It has also been investigated as a chelator of copper and zinc ions for the possible treatment of Alzheimer's disease.	2.37	2	0	monohydroxyquinoline; organochlorine compound; organoiodine compound	antibacterial agent; antifungal agent; antimicrobial agent; antineoplastic agent; antiprotozoal drug; chelator; copper chelator
clobazam Clobazam: A benzodiazepine derivative that is a long-acting GABA-A RECEPTOR agonist. It is used as an antiepileptic in the treatment of SEIZURES, including seizures associated with LENNOX-GASTAUT SYNDROME. It is also used as an anxiolytic, for the short-term treatment of acute ANXIETY.. clobazam : 7-Chloro-1H-1,5-benzodiazepine-2,4(3H,5H)-dione in which the hydrogen attached to the nitrogen at position 1 is substituted by a methyl group, whilst that attached to the other nitrogen is substituted by a phenyl group. It is used for the short-term management of acute anxiety and as an adjunct in the treatment of epilepsy in association with other antiepileptics.	2	1	0	1,4-benzodiazepinone; organochlorine compound	anticonvulsant; anxiolytic drug; GABA modulator
clofibrate angiokapsul: contains clofibrate & insoitolnicotinate	3.23	1	0	aromatic ether; ethyl ester; monochlorobenzenes	anticholesteremic drug; antilipemic drug; geroprotector; PPARalpha agonist
clomiphene [no description available]	3.23	1	0	tertiary amine	estrogen antagonist; estrogen receptor modulator
clomipramine Clomipramine: A tricyclic antidepressant similar to IMIPRAMINE that selectively inhibits the uptake of serotonin in the brain. It is readily absorbed from the gastrointestinal tract and demethylated in the liver to form its primary active metabolite, desmethylclomipramine.. clomipramine : A dibenzoazepine that is 10,11-dihydro-5H-dibenzo[b,f]azepine which is substituted by chlorine at position 3 and in which the hydrogen attached to the nitrogen is replaced by a 3-(dimethylamino)propyl group. One of the more sedating tricyclic antidepressants, it is used as the hydrochloride salt for the treatment of depression as well as obsessive-compulsive disorder and phobias.	4.02	4	0	dibenzoazepine	anticoronaviral agent; antidepressant; EC 1.8.1.12 (trypanothione-disulfide reductase) inhibitor; serotonergic antagonist; serotonergic drug; serotonin uptake inhibitor
clonazepam Clonazepam: An anticonvulsant used for several types of seizures, including myotonic or atonic seizures, photosensitive epilepsy, and absence seizures, although tolerance may develop. It is seldom effective in generalized tonic-clonic or partial seizures. The mechanism of action appears to involve the enhancement of GAMMA-AMINOBUTYRIC ACID receptor responses.. clonazepam : 1,3-Dihydro-2H-1,4-benzodiazepin-2-one in which the hydrogens at positions 5 and 7 are substituted by 2-chlorophenyl and nitro groups, respectively. It is used in the treatment of all types of epilepsy and seizures, as well as myoclonus and associated abnormal movements, and panic disorders. However, its use can be limited by the development of tolerance and by sedation.	4.06	4	0	1,4-benzodiazepinone; monochlorobenzenes	anticonvulsant; anxiolytic drug; GABA modulator
clonidine Clonidine: An imidazoline sympatholytic agent that stimulates ALPHA-2 ADRENERGIC RECEPTORS and central IMIDAZOLINE RECEPTORS. It is commonly used in the management of HYPERTENSION.. clonidine (amino form) : A clonidine that is 4,5-dihydro-1H-imidazol-2-amine in which one of the amino hydrogens is replaced by a 2,6-dichlorophenyl group.	4.06	4	0	clonidine; imidazoline
chlorazepate clorazepic acid : A 1,4-benzodiazepinone in which the oxo group is at position 2, and which is substituted at positions 3, 5, and 7 by carboxy, phenyl and chloro groups, respectively.	3.58	2	0	1,4-benzodiazepinone	anticonvulsant; anxiolytic drug; GABA modulator; prodrug
clotrimazole [no description available]	3.23	1	0	conazole antifungal drug; imidazole antifungal drug; imidazoles; monochlorobenzenes	antiinfective agent; environmental contaminant; xenobiotic
cyclobenzaprine cyclobenzaprine: RN given refers to parent cpd; Lisseril is synonymous for HCl; structure. cyclobenzaprine : 5-Methylidene-5H-dibenzo[a,d]cycloheptene in which one of the hydrogens of the methylidene group is substituted by a 2-(dimethylamino)ethyl group. A centrally acting skeletal muscle relaxant, it is used as its hydrochloride salt in the symptomatic treatment of painful muscle spasm.	3.23	1	0	carbotricyclic compound	antidepressant; muscle relaxant; tranquilizing drug
cyclofenil Cyclofenil: A gonadal stimulant and inducer of ovulation. It is used in the treatment of infertility and amenorrhea, but is thought to be less effective than CLOMIPHENE.	3.23	1	0	organic molecular entity
cycloleucine Cycloleucine: An amino acid formed by cyclization of leucine. It has cytostatic, immunosuppressive and antineoplastic activities.. 1-aminocyclopentanecarboxylic acid : A non-proteinogenic alpha-amino acid that is cyclopentane substituted at position 1 by amino and carboxy groups.	2.04	1	0	non-proteinogenic alpha-amino acid	EC 2.5.1.6 (methionine adenosyltransferase) inhibitor
cyclopenthiazide Cyclopenthiazide: Thiazide diuretic also used as an antihypertensive agent.	1.95	1	0	benzothiadiazine
cyproheptadine Cyproheptadine: A serotonin antagonist and a histamine H1 blocker used as antipruritic, appetite stimulant, antiallergic, and for the post-gastrectomy dumping syndrome, etc.. cyproheptadine : The product resulting from the formal oxidative coupling of position 5 of 5H-dibenzo[a,d]cycloheptene with position 4 of 1-methylpiperidine resulting in the formation of a double bond between the two fragments. It is a sedating antihistamine with antimuscarinic and calcium-channel blocking actions. It is used (particularly as the hydrochloride sesquihydrate) for the relief of allergic conditions including rhinitis, conjunctivitis due to inhalant allergens and foods, urticaria and angioedema, and in pruritic skin disorders. Unlike other antihistamines, it is also a seratonin receptor antagonist, making it useful in conditions such as vascular headache and anorexia.	3.23	1	0	piperidines; tertiary amine	anti-allergic agent; antipruritic drug; gastrointestinal drug; H1-receptor antagonist; serotonergic antagonist
dapi DAPI: RN given refers to parent cpd.	2.05	1	0	indoles	fluorochrome
dapsone [no description available]	9.23	5	0	substituted aniline; sulfone	anti-inflammatory drug; antiinfective agent; antimalarial; leprostatic drug
debrisoquin Debrisoquin: An adrenergic neuron-blocking drug similar in effects to GUANETHIDINE. It is also noteworthy in being a substrate for a polymorphic cytochrome P-450 enzyme. Persons with certain isoforms of this enzyme are unable to properly metabolize this and many other clinically important drugs. They are commonly referred to as having a debrisoquin 4-hydroxylase polymorphism.	2.04	1	0	carboxamidine; isoquinolines	adrenergic agent; antihypertensive agent; human metabolite; sympatholytic agent
deferoxamine Deferoxamine: Natural product isolated from Streptomyces pilosus. It forms iron complexes and is used as a chelating agent, particularly in the mesylate form.. desferrioxamine B : An acyclic desferrioxamine that is butanedioic acid in which one of the carboxy groups undergoes formal condensation with the primary amino group of N-(5-aminopentyl)-N-hydroxyacetamide and the second carboxy group undergoes formal condensation with the hydroxyamino group of N(1)-(5-aminopentyl)-N(1)-hydroxy-N(4)-[5-(hydroxyamino)pentyl]butanediamide. It is a siderophore native to Streptomyces pilosus biosynthesised by the DesABCD enzyme cluster as a high affinity Fe(III) chelator.	3.55	2	0	acyclic desferrioxamine	bacterial metabolite; ferroptosis inhibitor; iron chelator; siderophore
desipramine Desipramine: A tricyclic dibenzazepine compound that potentiates neurotransmission. Desipramine selectively blocks reuptake of norepinephrine from the neural synapse, and also appears to impair serotonin transport. This compound also possesses minor anticholinergic activity, through its affinity to muscarinic receptors.. desipramine : A dibenzoazepine consisting of 10,11-dihydro-5H-dibenzo[b,f]azepine substituted on nitrogen with a 3-(methylamino)propyl group.	4.21	5	0	dibenzoazepine; secondary amino compound	adrenergic uptake inhibitor; alpha-adrenergic antagonist; antidepressant; cholinergic antagonist; drug allergen; EC 3.1.4.12 (sphingomyelin phosphodiesterase) inhibitor; EC 3.4.21.26 (prolyl oligopeptidase) inhibitor; H1-receptor antagonist; serotonin uptake inhibitor
nordazepam Nordazepam: An intermediate in the metabolism of DIAZEPAM to OXAZEPAM. It may have actions similar to those of diazepam.. nordazepam : A 1,4-benzodiazepinone having phenyl and chloro substituents at positions 5 and 7 respectively; it has anticonvulsant, anxiolytic, muscle relaxant and sedative properties but is used primarily in the treatment of anxiety.	2.42	2	0	1,4-benzodiazepinone; organochlorine compound	anticonvulsant; anxiolytic drug; GABA modulator; human metabolite; sedative
amphetamine Amphetamine: A powerful central nervous system stimulant and sympathomimetic. Amphetamine has multiple mechanisms of action including blocking uptake of adrenergics and dopamine, stimulation of release of monamines, and inhibiting monoamine oxidase. Amphetamine is also a drug of abuse and a psychotomimetic. The l- and the d,l-forms are included here. The l-form has less central nervous system activity but stronger cardiovascular effects. The d-form is DEXTROAMPHETAMINE.. 1-phenylpropan-2-amine : A primary amine that is isopropylamine in which a hydrogen attached to one of the methyl groups has been replaced by a phenyl group.. amphetamine : A racemate comprising equimolar amounts of (R)-amphetamine (also known as levamphetamine or levoamphetamine) and (S)-amphetamine (also known as dexamfetamine or dextroamphetamine.	3.58	2	0	primary amine
diazepam Diazepam: A benzodiazepine with anticonvulsant, anxiolytic, sedative, muscle relaxant, and amnesic properties and a long duration of action. Its actions are mediated by enhancement of GAMMA-AMINOBUTYRIC ACID activity.. diazepam : A 1,4-benzodiazepinone that is 1,3-dihydro-2H-1,4-benzodiazepin-2-one substituted by a chloro group at position 7, a methyl group at position 1 and a phenyl group at position 5.	4.85	11	0	1,4-benzodiazepinone; organochlorine compound	anticonvulsant; anxiolytic drug; environmental contaminant; sedative; xenobiotic
diazoxide Diazoxide: A benzothiadiazine derivative that is a peripheral vasodilator used for hypertensive emergencies. It lacks diuretic effect, apparently because it lacks a sulfonamide group.. diazoxide : A benzothiadiazine that is the S,S-dioxide of 2H-1,2,4-benzothiadiazine which is substituted at position 3 by a methyl group and at position 7 by chlorine. A peripheral vasodilator, it increases the concentration of glucose in the plasma and inhibits the secretion of insulin by the beta- cells of the pancreas. It is used orally in the management of intractable hypoglycaemia and intravenously in the management of hypertensive emergencies.	4.24	5	0	benzothiadiazine; organochlorine compound; sulfone	antihypertensive agent; beta-adrenergic agonist; bronchodilator agent; cardiotonic drug; diuretic; K-ATP channel agonist; sodium channel blocker; sympathomimetic agent; vasodilator agent
dicamba Dicamba: A chlorinated organic herbicide.. dicamba : A methoxybenzoic acid that is O-methylsalicylic acid substituted by chloro groups at positions 3 and 6.	2.04	1	0	dichlorobenzene; methoxybenzoic acid	agrochemical; environmental contaminant; herbicide; synthetic auxin; xenobiotic
diclofenac Diclofenac: A non-steroidal anti-inflammatory agent (NSAID) with antipyretic and analgesic actions. It is primarily available as the sodium salt.. diclofenac : A monocarboxylic acid consisting of phenylacetic acid having a (2,6-dichlorophenyl)amino group at the 2-position.	9.26	5	0	amino acid; aromatic amine; dichlorobenzene; monocarboxylic acid; secondary amino compound	antipyretic; drug allergen; EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor; environmental contaminant; non-narcotic analgesic; non-steroidal anti-inflammatory drug; xenobiotic
dichlorphenamide Dichlorphenamide: A carbonic anhydrase inhibitor that is used in the treatment of glaucoma.. diclofenamide : A sulfonamide that is benzene-1,3-disulfonamide in which the hydrogens at positions 4 and 5 are substituted by chlorine. An oral carbonic anhydrase inhibitor, it partially suppresses the secretion (inflow) of aqueous humor in the eye and so reduces intraocular pressure. It is used for the treatment of glaucoma.	3.58	2	0	dichlorobenzene; sulfonamide	antiglaucoma drug; EC 4.2.1.1 (carbonic anhydrase) inhibitor; ophthalmology drug
dicyclomine Dicyclomine: A muscarinic antagonist used as an antispasmodic and in urinary incontinence. It has little effect on glandular secretion or the cardiovascular system. It does have some local anesthetic properties and is used in gastrointestinal, biliary, and urinary tract spasms.. dicyclomine : The ester resulting from the formal condensation of 1-cyclohexylcyclohexanecarboxylic acid with 2-(diethylamino)ethanol. An anticholinergic, it is used as the hydrochloride to treat or prevent spasm in the muscles of the gastrointestinal tract, particularly that associated with irritable bowel syndrome.	3.58	2	0	carboxylic ester; tertiary amine	antispasmodic drug; muscarinic antagonist; parasympatholytic
diethylcarbamazine Diethylcarbamazine: An anthelmintic used primarily as the citrate in the treatment of filariasis, particularly infestations with Wucheria bancrofti or Loa loa.	2.04	1	0	N-carbamoylpiperazine; N-methylpiperazine
pentetic acid Pentetic Acid: An iron chelating agent with properties like EDETIC ACID. DTPA has also been used as a chelator for other metals, such as plutonium.	3.23	1	0	pentacarboxylic acid	copper chelator
diflunisal Diflunisal: A salicylate derivative and anti-inflammatory analgesic with actions and side effects similar to those of ASPIRIN.. diflunisal : An organofluorine compound comprising salicylic acid having a 2,4-difluorophenyl group at the 5-position.	4.05	4	0	monohydroxybenzoic acid; organofluorine compound	non-narcotic analgesic; non-steroidal anti-inflammatory drug
dimercaprol Dimercaprol: An anti-gas warfare agent that is effective against Lewisite (dichloro(2-chlorovinyl)arsine) and formerly known as British Anti-Lewisite or BAL. It acts as a chelating agent and is used in the treatment of arsenic, gold, and other heavy metal poisoning.. dimercaprol : A dithiol that is propane-1,2-dithiol in which one of the methyl hydrogens is replaced by a hydroxy group. a chelating agent originally developed during World War II as an experimental antidote against the arsenic-based poison gas Lewisite, it has been used clinically since 1949 for the treatment of poisoning by arsenic, mercury and gold. It can also be used for treatment of poisoning by antimony, bismuth and possibly thallium, and (with sodium calcium edetate) in cases of acute leaad poisoning. Administration is by (painful) intramuscular injection of a suspension of dimercaprol in peanut oil, typically every 4 hours for 2-10 days depending on the toxicity. In the past, dimercaprol was also used for the treatment of Wilson's disease, a severely debilitating genetic disorder in which the body tends to retain copper, with resultant liver and brain injury.	3.58	2	0	dithiol; primary alcohol	chelator
dinitolmide Dinitolmide: A coccidiostat for poultry.	2.04	1	0	dinitrotoluene
diphenhydramine Diphenhydramine: A histamine H1 antagonist used as an antiemetic, antitussive, for dermatoses and pruritus, for hypersensitivity reactions, as a hypnotic, an antiparkinson, and as an ingredient in common cold preparations. It has some undesired antimuscarinic and sedative effects.. diphenhydramine : An ether that is the benzhydryl ether of 2-(dimethylamino)ethanol. It is a H1-receptor antagonist used as a antipruritic and antitussive drug.. antitussive : An agent that suppresses cough. Antitussives have a central or a peripheral action on the cough reflex, or a combination of both. Compare with expectorants, which are considered to increase the volume of secretions in the respiratory tract, so facilitating their removal by ciliary action and coughing, and mucolytics, which decrease the viscosity of mucus, facilitating its removal by ciliary action and expectoration.	4.06	4	0	ether; tertiary amino compound	anti-allergic agent; antidyskinesia agent; antiemetic; antiparkinson drug; antipruritic drug; antitussive; H1-receptor antagonist; local anaesthetic; muscarinic antagonist; oneirogen; sedative
dipyridamole Dipyridamole: A phosphodiesterase inhibitor that blocks uptake and metabolism of adenosine by erythrocytes and vascular endothelial cells. Dipyridamole also potentiates the antiaggregating action of prostacyclin. (From AMA Drug Evaluations Annual, 1994, p752). dipyridamole : A pyrimidopyrimidine that is 2,2',2'',2'''-(pyrimido[5,4-d]pyrimidine-2,6-diyldinitrilo)tetraethanol substituted by piperidin-1-yl groups at positions 4 and 8 respectively. A vasodilator agent, it inhibits the formation of blood clots.	3.58	2	0	piperidines; pyrimidopyrimidine; tertiary amino compound; tetrol	adenosine phosphodiesterase inhibitor; EC 3.5.4.4 (adenosine deaminase) inhibitor; platelet aggregation inhibitor; vasodilator agent
dipyrithione [no description available]	2.05	1	0	pyridinium ion
dipyrone metamizole : A pyrazole that is antiipyrine substituted at C-4 by a methyl(sulfomethyl)amino group, the sodium salt of which, metamizole sodium, was widely used as a powerful analgesic and antipyretic, but withdrawn from many markets from the 1970s due to a risk of causing risk of causing agranulocytosis.	2.04	1	0	amino sulfonic acid; pyrazoles	anti-inflammatory agent; antipyretic; antirheumatic drug; cyclooxygenase 3 inhibitor; non-narcotic analgesic; peripheral nervous system drug; prodrug
disopyramide Disopyramide: A class I anti-arrhythmic agent (one that interferes directly with the depolarization of the cardiac membrane and thus serves as a membrane-stabilizing agent) with a depressant action on the heart similar to that of guanidine. It also possesses some anticholinergic and local anesthetic properties.. disopyramide : A monocarboxylic acid amide that is butanamide substituted by a diisopropylamino group at position 4, a phenyl group at position 2 and a pyridin-2-yl group at position 2. It is used as a anti-arrhythmia drug.	4.24	5	0	monocarboxylic acid amide; pyridines; tertiary amino compound	anti-arrhythmia drug
stallimycin [no description available]	2.05	1	0
disulfiram [no description available]	3.58	2	0	organic disulfide; organosulfur acaricide	angiogenesis inhibitor; antineoplastic agent; apoptosis inducer; EC 1.2.1.3 [aldehyde dehydrogenase (NAD(+))] inhibitor; EC 3.1.1.1 (carboxylesterase) inhibitor; EC 3.1.1.8 (cholinesterase) inhibitor; EC 5.99.1.2 (DNA topoisomerase) inhibitor; ferroptosis inducer; fungicide; NF-kappaB inhibitor
valproic acid Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.. valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.	4.24	5	0	branched-chain fatty acid; branched-chain saturated fatty acid	anticonvulsant; antimanic drug; EC 3.5.1.98 (histone deacetylase) inhibitor; GABA agent; neuroprotective agent; psychotropic drug; teratogenic agent
domperidone Domperidone: A specific blocker of dopamine receptors. It speeds gastrointestinal peristalsis, causes prolactin release, and is used as antiemetic and tool in the study of dopaminergic mechanisms.. domperidone : 1-[3-(Piperidin-1-yl)propyl]-1,3-dihydro-2H-benzimidazol-2-one in which the 4-position of the piperidine ring is substituted by a 5-chloro-1,3-dihydro-2H-benzimidazol-2-on-1-yl group. A dopamine antagonist, it is used as an antiemetic for the short-term treatment of nausea and vomiting, and to control gastrointestinal effects of dopaminergic drugs given in the management of parkinsonism. The free base is used in oral suspensions, while the maleate salt is used in tablet preparations.	2.94	4	0	benzimidazoles; heteroarylpiperidine	antiemetic; dopaminergic antagonist
donepezil Donepezil: An indan and piperidine derivative that acts as a selective and reversible inhibitor of ACETYLCHOLINESTERASE. Donepezil is highly selective for the central nervous system and is used in the management of mild to moderate DEMENTIA in ALZHEIMER DISEASE.. donepezil : A racemate comprising equimolar amounts of (R)- and (S)-donepezil. A centrally acting reversible acetylcholinesterase inhibitor, its main therapeutic use is in the treatment of Alzheimer's disease where it is used to increase cortical acetylcholine.. 2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxyindan-1-one : A member of the class of indanones that is 5,6-dimethoxyindan-1-one which is substituted at position 2 by an (N-benzylpiperidin-4-yl)methyl group.	3.23	1	0	aromatic ether; indanones; piperidines; racemate	EC 3.1.1.7 (acetylcholinesterase) inhibitor; EC 3.1.1.8 (cholinesterase) inhibitor; nootropic agent
doxapram Doxapram: A central respiratory stimulant with a brief duration of action. (From Martindale, The Extra Pharmocopoeia, 30th ed, p1225). doxapram : A member of the class of pyrrolidin-2-ones that is N-ethylpyrrolidin-2-one in which both of the hydrogens at the 3 position (adjacent to the carbonyl group) are substituted by phenyl groups, and one of the hydrogens at the 4 position is substituted by a 2-(morpholin-4-yl)ethyl group. A central and respiratory stimulant with a brief duration of action, it is used (generally as the hydrochloride or the hydrochloride hydrate) as a temporary treatment of acute respiratory failure, particularly when superimposed on chronic obstructive pulmonary disease, and of postoperative respiratory depression. It has also been used for treatment of postoperative shivering.	3.58	2	0	morpholines; pyrrolidin-2-ones	central nervous system stimulant
doxazosin Doxazosin: A prazosin-related compound that is a selective alpha-1-adrenergic blocker.. doxazosin : A member of the class of quinazolines that is quinazoline substituted by an amino group at position 4, methoxy groups at positions 6 and 7 and a piperazin-1-yl group at position 2 which in turn is substituted by a 2,3-dihydro-1,4-benzodioxin-2-ylcarbonyl group at position 4. An antihypertensive agent, it is used in the treatment of high blood pressure.	3.83	3	0	aromatic amine; benzodioxine; monocarboxylic acid amide; N-acylpiperazine; N-arylpiperazine; quinazolines	alpha-adrenergic antagonist; antihyperplasia drug; antihypertensive agent; antineoplastic agent; vasodilator agent
doxepin Doxepin: A dibenzoxepin tricyclic compound. It displays a range of pharmacological actions including maintaining adrenergic innervation. Its mechanism of action is not fully understood, but it appears to block reuptake of monoaminergic neurotransmitters into presynaptic terminals. It also possesses anticholinergic activity and modulates antagonism of histamine H(1)- and H(2)-receptors.. doxepin : A dibenzooxepine that is 6,11-dihydrodibenzo[b,e]oxepine substituted by a 3-(dimethylamino)propylidene group at position 11. It is used as an antidepressant drug.	4.06	4	0	dibenzooxepine; tertiary amino compound	antidepressant
doxylamine Doxylamine: Histamine H1 antagonist with pronounced sedative properties. It is used in allergies and as an antitussive, antiemetic, and hypnotic. Doxylamine has also been administered in veterinary applications and was formerly used in PARKINSONISM.	3.23	1	0	pyridines; tertiary amine	anti-allergic agent; antiemetic; antitussive; cholinergic antagonist; H1-receptor antagonist; histamine antagonist; sedative
droperidol Droperidol: A butyrophenone with general properties similar to those of HALOPERIDOL. It is used in conjunction with an opioid analgesic such as FENTANYL to maintain the patient in a calm state of neuroleptanalgesia with indifference to surroundings but still able to cooperate with the surgeon. It is also used as a premedicant, as an antiemetic, and for the control of agitation in acute psychoses. (From Martindale, The Extra Pharmacopoeia, 29th ed, p593). droperidol : An organofluorine compound that is haloperidol in which the hydroxy group has been eliminated with the introduction of a double bond in the piperidine ring, and the 4-chlorophenyl group has been replaced by a benzimidazol-2-on-1-yl group. It is used in the management of chemotherapy-induced nausea and vomiting, and in conjunction with an opioid analgesic such as fentanyl to maintain the patient in a calm state of neuroleptanalgesia with indifference to surroundings but still able to cooperate with the surgeon.	3.23	1	0	aromatic ketone; benzimidazoles; organofluorine compound	anaesthesia adjuvant; antiemetic; dopaminergic antagonist; first generation antipsychotic
dyphylline Dyphylline: A THEOPHYLLINE derivative with broncho- and vasodilator properties. It is used in the treatment of asthma, cardiac dyspnea, and bronchitis.. dyphylline : An oxopurine that is theophylline bearing a 2,3-dihydroxypropyl group at the 7 position. It has broncho- and vasodilator properties, and is used in the treatment of asthma, cardiac dyspnea, and bronchitis. It is also an ingredient in preparations that have been promoted for coughs.	3.85	3	0	oxopurine; propane-1,2-diols	bronchodilator agent; EC 3.1.4.* (phosphoric diester hydrolase) inhibitor; muscle relaxant; vasodilator agent
econazole Econazole: An imidazole derivative that is commonly used as a topical antifungal agent.. econazole : A racemate composed of equimolar amounts of (R)- and (S)-econazole. Used (as its nitrate salt) to treat skin infections such as athlete's foot, jock itch, ringworm and other fungal skin infections.. 1-{2-(4-chlorobenzyloxy)-2-(2,4-dichlorophenyl)ethyl}imidazole : A member of the class of imidazoles that is 1-(2,4-dichlorophenyl)-2-(imidazol-1-yl)ethanol in which the hydroxyl hydrogen is replaced by a 4-chlorobenzyl group.	2.21	1	0	dichlorobenzene; ether; imidazoles; monochlorobenzenes
edrophonium Edrophonium: A rapid-onset, short-acting cholinesterase inhibitor used in cardiac arrhythmias and in the diagnosis of myasthenia gravis. It has also been used as an antidote to curare principles.. edrophonium : A quaternary ammonium ion that is N-ethyl-N,N-dimethylanilinium in which one of the meta positions is substituted by a hydroxy group. It is a reversible inhibitor of cholinesterase, with a rapid onset (30-60 seconds after injection) but a short duration of action (5-15 minutes). The chloride salt is used in myasthenia gravis both diagnostically and to distinguish between under- or over-treatment with other anticholinesterases. It has also been used for the reversal of neuromuscular blockade in anaesthesia, and for the management of poisoning due to tetrodotoxin, a neuromuscular blocking toxin found in puffer fish and other marine animals.	3.23	1	0	phenols; quaternary ammonium ion	antidote; diagnostic agent; EC 3.1.1.8 (cholinesterase) inhibitor
embelin embelin: from Embelia fruit (Myrsinaceae). embelin : A member of the class of dihydroxy-1,4-benzoquinones that is 2,5-dihydroxy-1,4-benzoquinone which is substituted by an undecyl group at position 3. Isolated from Lysimachia punctata and Embelia ribes, it exhibits antimicrobial, antineoplastic and inhibitory activity towards hepatitis C protease.	2.13	1	0	dihydroxy-1,4-benzoquinones	antimicrobial agent; antineoplastic agent; hepatitis C protease inhibitor; plant metabolite
emodin Emodin: Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as a laxative, but is now used mainly as a tool in toxicity studies.. emodin : A trihydroxyanthraquinone that is 9,10-anthraquinone which is substituted by hydroxy groups at positions 1, 3, and 8 and by a methyl group at position 6. It is present in the roots and barks of numerous plants (particularly rhubarb and buckthorn), moulds, and lichens. It is an active ingredient of various Chinese herbs.	7.05	1	0	trihydroxyanthraquinone	antineoplastic agent; laxative; plant metabolite; tyrosine kinase inhibitor
enoxacin Enoxacin: A broad-spectrum 6-fluoronaphthyridinone antibacterial agent that is structurally related to NALIDIXIC ACID.. enoxacin : A 1,8-naphthyridine derivative that is 1,4-dihydro-1,8-naphthyridine with an ethyl group at the 1 position, a carboxy group at the 3-position, an oxo sustituent at the 4-position, a fluoro substituent at the 5-position and a piperazin-1-yl group at the 7 position. An antibacterial, it is used in the treatment of urinary-tract infections and gonorrhoea.	2.68	3	0	1,8-naphthyridine derivative; amino acid; fluoroquinolone antibiotic; monocarboxylic acid; N-arylpiperazine; quinolone antibiotic	antibacterial drug; DNA synthesis inhibitor
erythrosine Fluoresceins: A family of spiro(isobenzofuran-1(3H),9'-(9H)xanthen)-3-one derivatives. These are used as dyes, as indicators for various metals, and as fluorescent labels in immunoassays.	1.95	1	0
estazolam Estazolam: A benzodiazepine with anticonvulsant, hypnotic, and muscle relaxant properties. It has been shown in some cases to be more potent than DIAZEPAM or NITRAZEPAM.. estazolam : A triazolo[4,3-a][1,4]benzodiazepine having a phenyl group at position 6 and a chloro substituent at position 8. A short-acting benzodiazepine with general properties similar to diazepam, it is given by mouth as a hypnotic in the short-term management of insomnia.	3.23	1	0	triazoles; triazolobenzodiazepine	anticonvulsant; anxiolytic drug; GABA modulator
ethacrynic acid Ethacrynic Acid: A compound that inhibits symport of sodium, potassium, and chloride primarily in the ascending limb of Henle, but also in the proximal and distal tubules. This pharmacological action results in excretion of these ions, increased urinary output, and reduction in extracellular fluid. This compound has been classified as a loop or high ceiling diuretic.. etacrynic acid : An aromatic ether that is phenoxyacetic acid in which the phenyl ring is substituted by chlorines at positions 2 and 3, and by a 2-methylidenebutanoyl group at position 4. It is a loop diuretic used to treat high blood pressure resulting from diseases such as congestive heart failure, liver failure, and kidney failure. It is also a glutathione S-transferase (EC 2.5.1.18) inhibitor.	3.79	3	0	aromatic ether; aromatic ketone; dichlorobenzene; monocarboxylic acid	EC 2.5.1.18 (glutathione transferase) inhibitor; ion transport inhibitor; loop diuretic
ethinamate ethinamate: short duration hypnotic with fast onset & relatively low toxicity; may cause dependence; minor descriptor (76-85); on-line & Index Medicus search CARBAMATES (76-85). ethinamate : A carbamate ester that is the 1-vinylcyclohexyl ester of carbamic acid. A short-acting sedative-hypnotic, it was formerly used to treat insomnia.	2.04	1	0	carbamate ester; terminal acetylenic compound	sedative
ethosuximide Ethosuximide: An anticonvulsant especially useful in the treatment of absence seizures unaccompanied by other types of seizures.. ethosuximide : A dicarboximide that is pyrrolidine-2,5-dione in which the hydrogens at position 3 are substituted by one methyl and one ethyl group. An antiepileptic, it is used in the treatment of absence seizures and may be used for myoclonic seizures, but is ineffective against tonic-clonic seizures.	3.83	3	0	dicarboximide; pyrrolidinone	anticonvulsant; geroprotector; T-type calcium channel blocker
ethotoin ethotoin: was heading 1966-94 (see under HYDANTOINS 1966-90); use HYDANTOINS to search ETHOTOIN 1966-94. ethotoin : An imidazolidine-2,4-dione that is hydantoin substituted by ethyl and phenyl at positions 3 and 5, respectively. An antiepileptic, it is less toxic than phenytoin but also less effective.	3.23	1	0	imidazolidine-2,4-dione	anticonvulsant
etidronate Etidronic Acid: A diphosphonate which affects calcium metabolism. It inhibits ectopic calcification and slows down bone resorption and bone turnover.. etidronic acid : A 1,1-bis(phosphonic acid) that is (ethane-1,1-diyl)bis(phosphonic acid) having a hydroxy substituent at the 1-position. It inhibits the formation, growth, and dissolution of hydroxyapatite crystals by chemisorption to calcium phosphate surfaces.	3.23	1	0	1,1-bis(phosphonic acid)	antineoplastic agent; bone density conservation agent; chelator
etilefrine Etilefrine: A phenylephrine-related beta-1 adrenergic and alpha adrenergic agonist used as a cardiotonic and antihypotensive agent.	2.72	3	0	phenols
etodolac Etodolac: A non-steroidal anti-inflammatory agent and cyclooxygenase-2 (COX-2) inhibitor with potent analgesic and anti-arthritic properties. It has been shown to be effective in the treatment of OSTEOARTHRITIS; RHEUMATOID ARTHRITIS; ANKYLOSING SPONDYLITIS; and in the alleviation of postoperative pain (PAIN, POSTOPERATIVE).. etodolac : A monocarboxylic acid that is acetic acid in which one of the methyl hydrogens is substituted by a 1,8-diethyl-1,3,4,9-tetrahydropyrano[3,4-b]indol-1-yl moiety. A preferential inhibitor of cyclo-oxygenase 2 and non-steroidal anti-inflammatory, it is used for the treatment of rheumatoid arthritis and osteoarthritis, and for the alleviation of postoperative pain. Administered as the racemate, only the (S)-enantiomer is active.	3.54	2	0	monocarboxylic acid; organic heterotricyclic compound	antipyretic; cyclooxygenase 2 inhibitor; non-narcotic analgesic; non-steroidal anti-inflammatory drug
brl 42810 [no description available]	3.23	1	0	2-aminopurines; acetate ester	antiviral drug; prodrug
felbamate Felbamate: A PEGylated phenylcarbamate derivative that acts as an antagonist of NMDA RECEPTORS. It is used as an anticonvulsant, primarily for the treatment of SEIZURES in severe refractory EPILEPSY.. felbamate : The bis(carbamate ester) of 2-phenylpropane-1,3-diol. An anticonvulsant, it is used in the treatment of epilepsy.	3.23	1	0	carbamate ester	anticonvulsant; neuroprotective agent
felodipine Felodipine: A dihydropyridine calcium antagonist with positive inotropic effects. It lowers blood pressure by reducing peripheral vascular resistance through a highly selective action on smooth muscle in arteriolar resistance vessels.. felodipine : The mixed (methyl, ethyl) diester of 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylic acid. A calcium-channel blocker, it lowers blood pressure by reducing peripheral vascular resistance through a highly selective action on smooth muscle in arteriolar resistance vessels. It is used in the management of hypertension and angina pectoris.	4.24	5	0	dichlorobenzene; dihydropyridine; ethyl ester; methyl ester	anti-arrhythmia drug; antihypertensive agent; calcium channel blocker; vasodilator agent
fenfluramine Fenfluramine: A centrally active drug that apparently both blocks serotonin uptake and provokes transport-mediated serotonin release.. fenfluramine : A secondary amino compound that is 1-phenyl-propan-2-amine in which one of the meta-hydrogens is substituted by trifluoromethyl, and one of the hydrogens attached to the nitrogen is substituted by an ethyl group. It binds to the serotonin reuptake pump, causing inhbition of serotonin uptake and release of serotonin. The resulting increased levels of serotonin lead to greater serotonin receptor activation which in turn lead to enhancement of serotoninergic transmission in the centres of feeding behavior located in the hypothalamus. This suppresses the appetite for carbohydrates. Fenfluramine was used as the hydrochloride for treatment of diabetes and obesity. It was withdrawn worldwide after reports of heart valve disease and pulmonary hypertension.	2	1	0	(trifluoromethyl)benzenes; secondary amino compound	appetite depressant; serotonergic agonist; serotonin uptake inhibitor
fenofibrate Pharmavit: a polyvitamin product, comprising vitamins A, D2, B1, B2, B6, C, E, nicotinamide, & calcium pantothene; may be a promising agent for application to human populations exposed to carcinogenic and genetic hazards of ionizing radiation; RN from CHEMLINE	3.23	1	0	aromatic ether; chlorobenzophenone; isopropyl ester; monochlorobenzenes	antilipemic drug; environmental contaminant; geroprotector; xenobiotic
fenoldopam Fenoldopam: A dopamine D1 receptor agonist that is used as an antihypertensive agent. It lowers blood pressure through arteriolar vasodilation.	3.23	1	0	benzazepine	alpha-adrenergic agonist; antihypertensive agent; dopamine agonist; dopaminergic antagonist; vasodilator agent
fenoprofen Fenoprofen: A propionic acid derivative that is used as a non-steroidal anti-inflammatory agent.. fenoprofen : A monocarboxylic acid that is propanoic acid in which one of the hydrogens at position 2 is substituted by a 3-phenoxyphenyl group. A non-steroidal anti-inflammatory drug, the dihydrate form of the calcium salt is used for the management of mild to moderate pain and for the relief of pain and inflammation associated with disorders such as arthritis. It is pharmacologically similar to aspirin, but causes less gastrointestinal bleeding.	3.23	1	0	monocarboxylic acid	antipyretic; cyclooxygenase 1 inhibitor; cyclooxygenase 2 inhibitor; drug allergen; non-narcotic analgesic; non-steroidal anti-inflammatory drug
berotek Fenoterol: A synthetic adrenergic beta-2 agonist that is used as a bronchodilator and tocolytic.. fenoterol : A member of the class resorcinols that is 5-(1-hydroxyethyl)benzene-1,3-diol in which one of the methyl hydrogens is replaced by a 1-(4-hydroxyphenyl)propan-2-amino group. A beta2-adrenergic agonist, it is used (as the hydrobromide salt) as a bronchodilator in the management of reversible airway obstruction.	2.72	3	0	resorcinols; secondary alcohol; secondary amino compound	beta-adrenergic agonist; bronchodilator agent; sympathomimetic agent; tocolytic agent
fenspiride fenspiride: was heading 1975-94 (see under SPIRO COMPOUNDS 1975-90); use SPIRO COMPOUNDS to search FENSPIRIDE 1975-94; bronchodilator agent used in asthma	2.04	1	0	azaspiro compound
fentanyl Fentanyl: A potent narcotic analgesic, abuse of which leads to habituation or addiction. It is primarily a mu-opioid agonist. Fentanyl is also used as an adjunct to general anesthetics, and as an anesthetic for induction and maintenance. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1078). fentanyl : A monocarboxylic acid amide resulting from the formal condensation of the aryl amino group of N-phenyl-1-(2-phenylethyl)piperidin-4-amine with propanoic acid.	2.45	2	0	anilide; monocarboxylic acid amide; piperidines	adjuvant; anaesthesia adjuvant; anaesthetic; intravenous anaesthetic; mu-opioid receptor agonist; opioid analgesic
fexofenadine fexofenadine: a second generation antihistamine; metabolite of the antihistaminic drug terfenadine; structure in first source; RN refers to HCl. fexofenadine : A piperidine-based anti-histamine compound.	3.23	1	0	piperidines; tertiary amine	anti-allergic agent; H1-receptor antagonist
fipexide fipexide: regulates dopaminergic systems at macromolecular level	3.23	1	0	benzodioxoles
flavoxate Flavoxate: A drug that has been used in various urinary syndromes and as an antispasmodic. Its therapeutic usefulness and its mechanism of action are not clear. It may have local anesthetic activity and direct relaxing effects on smooth muscle as well as some activity as a muscarinic antagonist.. flavoxate : A carboxylic ester resulting from the formal condensation of 3-methylflavone-8-carboxylic acid with 2-(1-piperidinyl)ethanol.	3.23	1	0	carboxylic ester; flavones; piperidines; tertiary amino compound	antispasmodic drug; muscarinic antagonist; parasympatholytic
flecainide Flecainide: A potent anti-arrhythmia agent, effective in a wide range of ventricular and atrial ARRHYTHMIAS and TACHYCARDIAS.. flecainide : A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 2,5-bis(2,2,2-trifluoroethoxy)benzoic acid with the primary amino group of piperidin-2-ylmethylamine. An antiarrhythmic agent used (in the form of its acetate salt) to prevent and treat tachyarrhythmia (abnormal fast rhythm of the heart).	4.24	5	0	aromatic ether; monocarboxylic acid amide; organofluorine compound; piperidines	anti-arrhythmia drug
fleroxacin Fleroxacin: A broad-spectrum antimicrobial fluoroquinolone. The drug strongly inhibits the DNA-supercoiling activity of DNA GYRASE.. fleroxacin : A fluoroquinolone antibiotic that is 4-oxo-1,4-dihydroquinoline which is substituted at positions 1, 3, 6, 7 and 8 by 2-fluoroethyl, carboxy, fluoro, 4-methylpiperazin-1-yl and fluoro groups, respectively. It is active against many Gram-positive and Gram-negative bacteria.	2.92	4	0	difluorobenzene; fluoroquinolone antibiotic; monocarboxylic acid; N-alkylpiperazine; quinolines	antibacterial drug; EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor; topoisomerase IV inhibitor
fluconazole Fluconazole: Triazole antifungal agent that is used to treat oropharyngeal CANDIDIASIS and cryptococcal MENINGITIS in AIDS.. fluconazole : A member of the class of triazoles that is propan-2-ol substituted at position 1 and 3 by 1H-1,2,4-triazol-1-yl groups and at position 2 by a 2,4-difluorophenyl group. It is an antifungal drug used for the treatment of mucosal candidiasis and for systemic infections including systemic candidiasis, coccidioidomycosis, and cryptococcosis.	4.98	11	0	conazole antifungal drug; difluorobenzene; tertiary alcohol; triazole antifungal drug	environmental contaminant; P450 inhibitor; xenobiotic
flucytosine Flucytosine: A fluorinated cytosine analog that is used as an antifungal agent.. flucytosine : An organofluorine compound that is cytosine that is substituted at position 5 by a fluorine. A prodrug for the antifungal 5-fluorouracil, it is used for the treatment of systemic fungal infections.	6.19	10	1	aminopyrimidine; nucleoside analogue; organofluorine compound; pyrimidine antifungal drug; pyrimidone	prodrug
flufenamic acid Flufenamic Acid: An anthranilic acid derivative with analgesic, anti-inflammatory, and antipyretic properties. It is used in musculoskeletal and joint disorders and administered by mouth and topically. (From Martindale, The Extra Pharmacopoeia, 30th ed, p16). flufenamic acid : An aromatic amino acid consisting of anthranilic acid carrying an N-(trifluoromethyl)phenyl substituent. An analgesic and anti-inflammatory, it is used in rheumatic disorders.	2.25	1	0	aromatic amino acid; organofluorine compound	antipyretic; EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor; non-narcotic analgesic; non-steroidal anti-inflammatory drug
fluphenazine [no description available]	3.58	2	0	N-alkylpiperazine; organofluorine compound; phenothiazines	anticoronaviral agent; dopaminergic antagonist; phenothiazine antipsychotic drug
flumazenil Flumazenil: A potent benzodiazepine receptor antagonist. Since it reverses the sedative and other actions of benzodiazepines, it has been suggested as an antidote to benzodiazepine overdoses.. flumazenil : An organic heterotricyclic compound that is 5,6-dihydro-4H-imidazo[1,5-a][1,4]benzodiazepine which is substituted at positions 3, 5, 6, and 8 by ethoxycarbonyl, methyl, oxo, and fluoro groups, respectively. It is used as an antidote to benzodiazepine overdose.	4.06	4	0	ethyl ester; imidazobenzodiazepine; organofluorine compound	antidote to benzodiazepine poisoning; GABA antagonist
flunitrazepam Flunitrazepam: A benzodiazepine with pharmacologic actions similar to those of DIAZEPAM that can cause ANTEROGRADE AMNESIA. Some reports indicate that it is used as a date rape drug and suggest that it may precipitate violent behavior. The United States Government has banned the importation of this drug.. flunitrazepam : A 1,4-benzodiazepinone that is nitrazepam substituted by a methyl group at position 1 and by a fluoro group at position 2'. It is a potent hypnotic, sedative, and amnestic drug used to treat chronic insomnia.	2.42	2	0	1,4-benzodiazepinone; C-nitro compound; monofluorobenzenes	anxiolytic drug; GABAA receptor agonist; sedative
fluorescite fluorescein (acid form) : A xanthene dye that is highly fluorescent and commonly used as a fluorescent tracer.	3.58	2	0	benzoic acids; cyclic ketone; hydroxy monocarboxylic acid; organic heterotricyclic compound; phenols; xanthene dye	fluorescent dye; radioopaque medium
fluorouracil Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.. 5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.	4.4	6	0	nucleobase analogue; organofluorine compound	antimetabolite; antineoplastic agent; environmental contaminant; immunosuppressive agent; radiosensitizing agent; xenobiotic
fluoxetine Fluoxetine: The first highly specific serotonin uptake inhibitor. It is used as an antidepressant and often has a more acceptable side-effects profile than traditional antidepressants.. fluoxetine : A racemate comprising equimolar amounts of (R)- and (S)-fluoxetine. A selective serotonin reuptake inhibitor (SSRI), it is used (generally as the hydrochloride salt) for the treatment of depression (and the depressive phase of bipolar disorder), bullimia nervosa, and obsessive-compulsive disorder.. N-methyl-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propan-1-amine : An aromatic ether consisting of 4-trifluoromethylphenol in which the hydrogen of the phenolic hydroxy group is replaced by a 3-(methylamino)-1-phenylpropyl group.	3.54	2	0	(trifluoromethyl)benzenes; aromatic ether; secondary amino compound
flurazepam Flurazepam: A benzodiazepine derivative used mainly as a hypnotic.. flurazepam : A 1,4-benzodiazepinone that is 1,3-dihydro-2H-1,4-benzodiazepin-2-one substituted by a 2-(diethylamino)ethyl group, 2-fluorophenyl group and chloro group at positions 1, 5 and 7, respectively. It is a partial agonist of GABAA receptors and used for the treatment of insomnia.	3.23	1	0	1,4-benzodiazepinone; monofluorobenzenes; organochlorine compound; tertiary amino compound	anticonvulsant; anxiolytic drug; GABAA receptor agonist; sedative
flurbiprofen Flurbiprofen: An anti-inflammatory analgesic and antipyretic of the phenylalkynoic acid series. It has been shown to reduce bone resorption in periodontal disease by inhibiting CARBONIC ANHYDRASE.. flurbiprofen : A monocarboxylic acid that is a 2-fluoro-[1,1'-biphenyl-4-yl] moiety linked to C-2 of propionic acid. A non-steroidal anti-inflammatory, analgesic and antipyretic, it is used as a pre-operative anti-miotic as well as orally for arthritis or dental pain.	3.54	2	0	fluorobiphenyl; monocarboxylic acid	antipyretic; EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor; non-narcotic analgesic; non-steroidal anti-inflammatory drug
flutamide Flutamide: An antiandrogen with about the same potency as cyproterone in rodent and canine species.	3.58	2	0	(trifluoromethyl)benzenes; monocarboxylic acid amide	androgen antagonist; antineoplastic agent
fomepizole Fomepizole: A pyrazole and competitive inhibitor of ALCOHOL DEHYDROGENASE that is used for the treatment of poisoning by ETHYLENE GLYCOL or METHANOL.. fomepizole : A member of the class of pyrazoles that is 1H-pyrazole substituted by a methyl group at position 4.	3.23	1	0	pyrazoles	antidote; EC 1.1.1.1 (alcohol dehydrogenase) inhibitor; protective agent
foscarnet Foscarnet: An antiviral agent used in the treatment of cytomegalovirus retinitis. Foscarnet also shows activity against human herpesviruses and HIV.. phosphonoformic acid : Phosphoric acid in which one of the hydroxy groups is replaced by a carboxylic acid group. It is used as the trisodium salt as an antiviral agent in the treatment of cytomegalovirus retinitis (CMV retinitis, an inflamation of the retina that can lead to blindness) and as an alternative to ganciclovir for AIDS patients who require concurrent antiretroviral therapy but are unable to tolerate ganciclovir due to haematological toxicity.	3.85	3	0	carboxylic acid; one-carbon compound; phosphonic acids	antiviral drug; geroprotector; HIV-1 reverse transcriptase inhibitor; sodium-dependent Pi-transporter inhibitor
furazolidone Furazolidone: A nitrofuran derivative with antiprotozoal and antibacterial activity. Furazolidone acts by gradual inhibition of monoamine oxidase. (From Martindale, The Extra Pharmacopoeia, 30th ed, p514). furazolidone : A member of the class of oxazolidines that is 1,3-oxazolidin-2-one in which the hydrogen attached to the nitrogen is replaced by an N-{[(5-nitro-2-furyl)methylene]amino} group. It has antibacterial and antiprotozoal properties, and is used in the treatment of giardiasis and cholera.	2.35	2	0	nitrofuran antibiotic; oxazolidines	antibacterial drug; antiinfective agent; antitrichomonal drug; EC 1.4.3.4 (monoamine oxidase) inhibitor
furosemide Furosemide: A benzoic-sulfonamide-furan. It is a diuretic with fast onset and short duration that is used for EDEMA and chronic RENAL INSUFFICIENCY.. furosemide : A chlorobenzoic acid that is 4-chlorobenzoic acid substituted by a (furan-2-ylmethyl)amino and a sulfamoyl group at position 2 and 5 respectively. It is a diuretic used in the treatment of congestive heart failure.	4.7	9	0	chlorobenzoic acid; furans; sulfonamide	environmental contaminant; loop diuretic; xenobiotic
gabapentin Gabapentin: A cyclohexane-gamma-aminobutyric acid derivative that is used for the treatment of PARTIAL SEIZURES; NEURALGIA; and RESTLESS LEGS SYNDROME.. gabapentin : A gamma-amino acid that is cyclohexane substituted at position 1 by aminomethyl and carboxymethyl groups. Used for treatment of neuropathic pain and restless legs syndrome.	3.85	3	0	gamma-amino acid	anticonvulsant; calcium channel blocker; environmental contaminant; xenobiotic
gemfibrozil [no description available]	3.83	3	0	aromatic ether	antilipemic drug
gentamicin Gentamicins: A complex of closely related aminoglycosides obtained from MICROMONOSPORA purpurea and related species. They are broad-spectrum antibiotics, but may cause ear and kidney damage. They act to inhibit PROTEIN BIOSYNTHESIS.	11.86	173	2
glafenine Glafenine: An anthranilic acid derivative with analgesic properties used for the relief of all types of pain.. glafenine : A carboxylic ester that is 2,3-dihydroxypropyl anthranilate in which the amino group is substituted by a 7-chloroquinolin-4-yl group. A non-steroidal anti-inflammatory drug, glafenine and its hydrochloride salt were used for the relief of all types of pain, but high incidence of anaphylactic reactions resulted in their withdrawal from the market.	3.23	1	0	aminoquinoline; carboxylic ester; glycol; organochlorine compound; secondary amino compound	inhibitor; non-narcotic analgesic; non-steroidal anti-inflammatory drug
glimepiride glimepiride: structure given in first source	3.85	3	0	sulfonamide
glipizide Glipizide: An oral hypoglycemic agent which is rapidly absorbed and completely metabolized.. glipizide : An N-sulfonylurea that is glyburide in which the (5-chloro-2-methoxybenzoyl group is replaced by a (5-methylpyrazin-2-yl)carbonyl group. An oral hypoglycemic agent, it is used in the treatment of type 2 diabetes mellitus.	4.06	4	0	aromatic amide; monocarboxylic acid amide; N-sulfonylurea; pyrazines	EC 2.7.1.33 (pantothenate kinase) inhibitor; hypoglycemic agent; insulin secretagogue
glutethimide Glutethimide: A hypnotic and sedative. Its use has been largely superseded by other drugs.	2.04	1	0	piperidines
glyburide Glyburide: An antidiabetic sulfonylurea derivative with actions like those of chlorpropamide. glyburide : An N-sulfonylurea that is acetohexamide in which the acetyl group is replaced by a 2-(5-chloro-2-methoxybenzamido)ethyl group.	4.24	5	0	monochlorobenzenes; N-sulfonylurea	anti-arrhythmia drug; EC 2.7.1.33 (pantothenate kinase) inhibitor; EC 3.6.3.49 (channel-conductance-controlling ATPase) inhibitor; hypoglycemic agent
2-cyclopentyl-2-hydroxy-2-phenylacetic acid (1,1-dimethyl-3-pyrrolidin-1-iumyl) ester [no description available]	3.23	1	0	benzenes
granisetron [no description available]	3.85	3	0	aromatic amide; indazoles
guaifenesin Guaifenesin: An expectorant that also has some muscle relaxing action. It is used in many cough preparations.	3.23	1	0	methoxybenzenes
guanethidine Guanethidine: An antihypertensive agent that acts by inhibiting selectively transmission in post-ganglionic adrenergic nerves. It is believed to act mainly by preventing the release of norepinephrine at nerve endings and causes depletion of norepinephrine in peripheral sympathetic nerve terminals as well as in tissues.. guanethidine : A member of the class of guanidines in which one of the hydrogens of the amino group has been replaced by a 2-azocan-1-ylethyl group.. guanethidine sulfate : A organic sulfate salt composed of two molecules of guanethidine and one of sulfuric acid.	3.58	2	0	azocanes; guanidines	adrenergic antagonist; antihypertensive agent; sympatholytic agent
guanfacine Guanfacine: A centrally acting antihypertensive agent with specificity towards ADRENERGIC ALPHA-2 RECEPTORS.	3.85	3	0	acetamides
guanidine Guanidine: A strong organic base existing primarily as guanidium ions at physiological pH. It is found in the urine as a normal product of protein metabolism. It is also used in laboratory research as a protein denaturant. (From Martindale, the Extra Pharmacopoeia, 30th ed and Merck Index, 12th ed) It is also used in the treatment of myasthenia and as a fluorescent probe in HPLC.. guanidine : An aminocarboxamidine, the parent compound of the guanidines.	3.23	1	0	carboxamidine; guanidines; one-carbon compound
haloperidol Haloperidol: A phenyl-piperidinyl-butyrophenone that is used primarily to treat SCHIZOPHRENIA and other PSYCHOSES. It is also used in schizoaffective disorder, DELUSIONAL DISORDERS, ballism, and TOURETTE SYNDROME (a drug of choice) and occasionally as adjunctive therapy in INTELLECTUAL DISABILITY and the chorea of HUNTINGTON DISEASE. It is a potent antiemetic and is used in the treatment of intractable HICCUPS. (From AMA Drug Evaluations Annual, 1994, p279). haloperidol : A compound composed of a central piperidine structure with hydroxy and p-chlorophenyl substituents at position 4 and an N-linked p-fluorobutyrophenone moiety.	4.06	4	0	aromatic ketone; hydroxypiperidine; monochlorobenzenes; organofluorine compound; tertiary alcohol	antidyskinesia agent; antiemetic; dopaminergic antagonist; first generation antipsychotic; serotonergic antagonist
halothane [no description available]	3.48	2	0	haloalkane; organobromine compound; organochlorine compound; organofluorine compound	inhalation anaesthetic
hexachlorophene Hexachlorophene: A chlorinated bisphenol antiseptic with a bacteriostatic action against Gram-positive organisms, but much less effective against Gram-negative organisms. It is mainly used in soaps and creams and is an ingredient of various preparations used for skin disorders. (From Martindale, The Extra Pharmacopoeia, 30th ed, p797). hexachlorophene : An organochlorine compound that is diphenylmethane in which each of the phenyl groups is substituted by chlorines at positions 2, 3, and 5, and by a hydroxy group at position 6. An antiseptic that is effective against Gram-positive organisms, it is used in soaps and creams for the treatment of various skin disorders. It is also used in agriculture as an acaricide and fungicide, but is not approved for such use within the European Union.	7.64	3	0	bridged diphenyl fungicide; polyphenol; trichlorobenzene	acaricide; antibacterial agent; antifungal agrochemical; antiseptic drug
hexobarbital Hexobarbital: A barbiturate that is effective as a hypnotic and sedative.. hexobarbital : A member of the class of barbiturates taht is barbituric acid substituted at N-1 by methyl and at C-5 by methyl and cyclohex-1-enyl groups.	2.72	3	0	barbiturates
ethidium Ethidium: A trypanocidal agent and possible antiviral agent that is widely used in experimental cell biology and biochemistry. Ethidium has several experimentally useful properties including binding to nucleic acids, noncompetitive inhibition of nicotinic acetylcholine receptors, and fluorescence among others. It is most commonly used as the bromide.. ethidium : The fluorescent compound widely used in experimental cell biology and biochemistry to reveal double-stranded DNA and RNA.	2.03	1	0	phenanthridines	fluorochrome; intercalator
hydralazine Hydralazine: A direct-acting vasodilator that is used as an antihypertensive agent.. hydralazine : The 1-hydrazino derivative of phthalazine; a direct-acting vasodilator that is used as an antihypertensive agent.	4.24	5	0	azaarene; hydrazines; ortho-fused heteroarene; phthalazines	antihypertensive agent; vasodilator agent
hydrochlorothiazide Hydrochlorothiazide: A thiazide diuretic often considered the prototypical member of this class. It reduces the reabsorption of electrolytes from the renal tubules. This results in increased excretion of water and electrolytes, including sodium, potassium, chloride, and magnesium. It is used in the treatment of several disorders including edema, hypertension, diabetes insipidus, and hypoparathyroidism.. hydrochlorothiazide : A benzothiadiazine that is 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide substituted by a chloro group at position 6 and a sulfonamide at 7. It is diuretic used for the treatment of hypertension and congestive heart failure.	3.83	3	0	benzothiadiazine; organochlorine compound; sulfonamide	antihypertensive agent; diuretic; environmental contaminant; xenobiotic
hydroflumethiazide Hydroflumethiazide: A thiazide diuretic with actions and uses similar to those of HYDROCHLOROTHIAZIDE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p822). hydroflumethiazide : A benzothiadiazine consisting of a 3,4-dihydro-HH-1,2,4-benzothiadiazine bicyclic system dioxygenated on sulfur and carrying trifluoromethyl and aminosulfonyl groups at positions 6 and 7 respectively. A diuretic with actions and uses similar to those of hydrochlorothiazide.	3.58	2	0	benzothiadiazine; thiazide	antihypertensive agent; diuretic
hydroxychloroquine Hydroxychloroquine: A chemotherapeutic agent that acts against erythrocytic forms of malarial parasites. Hydroxychloroquine appears to concentrate in food vacuoles of affected protozoa. It inhibits plasmodial heme polymerase. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p970). hydroxychloroquine : An aminoquinoline that is chloroquine in which one of the N-ethyl groups is hydroxylated at position 2. An antimalarial with properties similar to chloroquine that acts against erythrocytic forms of malarial parasites, it is mainly used as the sulfate salt for the treatment of lupus erythematosus, rheumatoid arthritis, and light-sensitive skin eruptions.	3.58	2	0	aminoquinoline; organochlorine compound; primary alcohol; secondary amino compound; tertiary amino compound	anticoronaviral agent; antimalarial; antirheumatic drug; dermatologic drug
hydroxyurea [no description available]	4.07	4	0	one-carbon compound; ureas	antimetabolite; antimitotic; antineoplastic agent; DNA synthesis inhibitor; EC 1.17.4.1 (ribonucleoside-diphosphate reductase) inhibitor; genotoxin; immunomodulator; radical scavenger; teratogenic agent
hydroxyzine Hydroxyzine: A histamine H1 receptor antagonist that is effective in the treatment of chronic urticaria, dermatitis, and histamine-mediated pruritus. Unlike its major metabolite CETIRIZINE, it does cause drowsiness. It is also effective as an antiemetic, for relief of anxiety and tension, and as a sedative.. hydroxyzine : A N-alkylpiperazine that is piperzine in which the nitrogens atoms are substituted by 2-(2-hydroxyethoxy)ethyl and (4-chlorophenyl)(phenyl)methyl groups respectively.	3.23	1	0	hydroxyether; monochlorobenzenes; N-alkylpiperazine	anticoronaviral agent; antipruritic drug; anxiolytic drug; dermatologic drug; H1-receptor antagonist
hypericin [no description available]	2.04	1	0
ibuprofen Midol: combination of cinnamedrine, phenacetin, aspirin & caffeine	4.54	7	0	monocarboxylic acid	antipyretic; cyclooxygenase 1 inhibitor; cyclooxygenase 2 inhibitor; drug allergen; environmental contaminant; geroprotector; non-narcotic analgesic; non-steroidal anti-inflammatory drug; radical scavenger; xenobiotic
phenelzine Phenelzine: One of the MONOAMINE OXIDASE INHIBITORS used to treat DEPRESSION; PHOBIC DISORDERS; and PANIC.	3.58	2	0	primary amine
lidocaine Lidocaine: A local anesthetic and cardiac depressant used as an antiarrhythmia agent. Its actions are more intense and its effects more prolonged than those of PROCAINE but its duration of action is shorter than that of BUPIVACAINE or PRILOCAINE.. lidocaine : The monocarboxylic acid amide resulting from the formal condensation of N,N-diethylglycine with 2,6-dimethylaniline.	4.36	6	0	benzenes; monocarboxylic acid amide; tertiary amino compound	anti-arrhythmia drug; drug allergen; environmental contaminant; local anaesthetic; xenobiotic
ifosfamide [no description available]	3.85	3	0	ifosfamides	alkylating agent; antineoplastic agent; environmental contaminant; immunosuppressive agent; xenobiotic
imipramine Imipramine: The prototypical tricyclic antidepressant. It has been used in major depression, dysthymia, bipolar depression, attention-deficit disorders, agoraphobia, and panic disorders. It has less sedative effect than some other members of this therapeutic group.. imipramine : A dibenzoazepine that is 5H-dibenzo[b,f]azepine substituted by a 3-(dimethylamino)propyl group at the nitrogen atom.	4.86	6	0	dibenzoazepine	adrenergic uptake inhibitor; antidepressant; EC 3.4.21.26 (prolyl oligopeptidase) inhibitor
amrinone Amrinone: A positive inotropic cardiotonic (CARDIOTONIC AGENTS) with vasodilator properties, phosphodiesterase 3 inhibitory activity, and the ability to stimulate calcium ion influx into the cardiac cell.. amrinone : A 3,4'-bipyridine substituted at positions 5 and 6 by an amino group and a keto function respectively. A pyridine phosphodiesterase 3 inhibitor, it is a drug that may improve the prognosis in patients with congestive heart failure.	4.24	5	0	bipyridines	EC 3.1.4.* (phosphoric diester hydrolase) inhibitor
indapamide Indapamide: A benzamide-sulfonamide-indole derived DIURETIC that functions by inhibiting SODIUM CHLORIDE SYMPORTERS.. indapamide : A sulfonamide formed by condensation of the carboxylic group of 4-chloro-3-sulfamoylbenzoic acid with the amino group of 2-methyl-2,3-dihydro-1H-indol-1-amine.	3.58	2	0	indoles; organochlorine compound; sulfonamide	antihypertensive agent; diuretic
indomethacin Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.. indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.	4.51	7	0	aromatic ether; indole-3-acetic acids; monochlorobenzenes; N-acylindole	analgesic; drug metabolite; EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor; environmental contaminant; gout suppressant; non-steroidal anti-inflammatory drug; xenobiotic metabolite; xenobiotic
iohexol Iohexol: An effective non-ionic, water-soluble contrast agent which is used in myelography, arthrography, nephroangiography, arteriography, and other radiographic procedures. Its low systemic toxicity is the combined result of low chemotoxicity and low osmolality.. iohexol : A benzenedicarboxamide compound having N-(2,3-dihydroxypropyl)carbamoyl groups at the 1- and 3-positions, iodo substituents at the 2-, 4- and 6-positions and an N-(2,3-dihydroxypropyl)acetamido group at the 5-position.	2.04	1	0	benzenedicarboxamide; organoiodine compound	environmental contaminant; radioopaque medium; xenobiotic
iopromide iopromide: structure given in first source. iopromide : A dicarboxylic acid diamide that consists of N-methylisophthalamide bearing three iodo substituents at positions 2, 4 and 6, a methoxyacetyl substituent at position 5 and two 2,3-dihydroxypropyl groups attached to the amide nitrogens. A water soluble x-ray contrast agent for intravascular administration.	2.45	2	0	dicarboxylic acid diamide; organoiodine compound	environmental contaminant; nephrotoxic agent; radioopaque medium; xenobiotic
iothalamic acid Iothalamic Acid: A contrast medium in diagnostic radiology with properties similar to those of diatrizoic acid. It is used primarily as its sodium and meglumine (IOTHALAMATE MEGLUMINE) salts.	2.04	1	0	organic molecular entity
ioversol [no description available]	3.23	1	0	amidobenzoic acid
iproniazid [no description available]	3.58	2	0	carbohydrazide; pyridines
avapro Irbesartan: A spiro compound, biphenyl and tetrazole derivative that acts as an angiotensin II type 1 receptor antagonist. It is used in the management of HYPERTENSION, and in the treatment of kidney disease.. irbesartan : A biphenylyltetrazole that is an angiotensin II receptor antagonist used mainly for the treatment of hypertension.	3.58	2	0	azaspiro compound; biphenylyltetrazole	angiotensin receptor antagonist; antihypertensive agent; environmental contaminant; xenobiotic
isocarboxazid Isocarboxazid: An MAO inhibitor that is effective in the treatment of major depression, dysthymic disorder, and atypical depression. It also is useful in the treatment of panic disorder and the phobic disorders. (From AMA, Drug Evaluations Annual, 1994, p311)	3.23	1	0	benzenes
isoniazid Hydra: A genus of freshwater polyps in the family Hydridae, order Hydroida, class HYDROZOA. They are of special interest because of their complex organization and because their adult organization corresponds roughly to the gastrula of higher animals.. hydrazide : Compounds derived from oxoacids RkE(=O)l(OH)m (l =/= 0) by replacing -OH by -NRNR2 (R groups are commonly H). (IUPAC).	4.71	9	0	carbohydrazide	antitubercular agent; drug allergen
isoproterenol Isoproterenol: Isopropyl analog of EPINEPHRINE; beta-sympathomimetic that acts on the heart, bronchi, skeletal muscle, alimentary tract, etc. It is used mainly as bronchodilator and heart stimulant.. isoprenaline : A secondary amino compound that is noradrenaline in which one of the hydrogens attached to the nitrogen is replaced by an isopropyl group. A sympathomimetic acting almost exclusively on beta-adrenergic receptors, it is used (mainly as the hydrochloride salt) as a bronghodilator and heart stimulant for the management of a variety of cardiac disorders.	4.05	4	0	catechols; secondary alcohol; secondary amino compound	beta-adrenergic agonist; bronchodilator agent; cardiotonic drug; sympathomimetic agent
isoxsuprine Isoxsuprine: A beta-adrenergic agonist that causes direct relaxation of uterine and vascular smooth muscle. Its vasodilating actions are greater on the arteries supplying skeletal muscle than on those supplying skin. It is used in the treatment of peripheral vascular disease and in premature labor.	3.23	1	0	alkylbenzene
isradipine Isradipine: A potent antagonist of CALCIUM CHANNELS that is highly selective for VASCULAR SMOOTH MUSCLE. It is effective in the treatment of chronic stable angina pectoris, hypertension, and congestive cardiac failure.	4.06	4	0	benzoxadiazole; dihydropyridine; isopropyl ester; methyl ester
itraconazole [no description available]	4.57	7	0	piperazines
ketamine Ketamine: A cyclohexanone derivative used for induction of anesthesia. Its mechanism of action is not well understood, but ketamine can block NMDA receptors (RECEPTORS, N-METHYL-D-ASPARTATE) and may interact with sigma receptors.. ketamine : A member of the class of cyclohexanones in which one of the hydrogens at position 2 is substituted by a 2-chlorophenyl group, while the other is substituted by a methylamino group.	3.83	3	0	cyclohexanones; monochlorobenzenes; secondary amino compound	analgesic; environmental contaminant; intravenous anaesthetic; neurotoxin; NMDA receptor antagonist; xenobiotic
ketanserin Ketanserin: A selective serotonin receptor antagonist with weak adrenergic receptor blocking properties. The drug is effective in lowering blood pressure in essential hypertension. It also inhibits platelet aggregation. It is well tolerated and is particularly effective in older patients.. ketanserin : A member of the class of quinazolines that is quinazoline-2,4(1H,3H)-dione which is substituted at position 3 by a 2-[4-(p-fluorobenzoyl)piperidin-1-yl]ethyl group.	2.45	2	0	aromatic ketone; organofluorine compound; piperidines; quinazolines	alpha-adrenergic antagonist; antihypertensive agent; cardiovascular drug; EC 3.4.21.26 (prolyl oligopeptidase) inhibitor; serotonergic antagonist
ketoconazole 1-acetyl-4-(4-{[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazine : A dioxolane that is 1,3-dioxolane which is substituted at positions 2, 2, and 4 by imidazol-1-ylmethyl, 2,4-dichlorophenyl, and [para-(4-acetylpiperazin-1-yl)phenoxy]methyl groups, respectively.	3.81	3	0	dichlorobenzene; dioxolane; ether; imidazoles; N-acylpiperazine; N-arylpiperazine
ketoprofen Ketoprofen: An IBUPROFEN-type anti-inflammatory analgesic and antipyretic. It is used in the treatment of rheumatoid arthritis and osteoarthritis.. ketoprofen : An oxo monocarboxylic acid that consists of propionic acid substituted by a 3-benzoylphenyl group at position 2.	4.06	4	0	benzophenones; oxo monocarboxylic acid	antipyretic; drug allergen; EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor; environmental contaminant; non-steroidal anti-inflammatory drug; xenobiotic
ketorolac Ketorolac: A pyrrolizine carboxylic acid derivative structurally related to INDOMETHACIN. It is an NSAID and is used principally for its analgesic activity. (From Martindale The Extra Pharmacopoeia, 31st ed). ketorolac : A racemate comprising equimolar amounts of (R)-(+)- and (S)-(-)-5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid. While only the (S)-(-) enantiomer is a COX1 and COX2 inhibitor, the (R)-(+) enantiomer exhibits potent analgesic activity. A non-steroidal anti-inflammatory drug, ketorolac is mainly used (generally as the tromethamine salt) for its potent analgesic properties in the short-term management of post-operative pain, and in eye drops to relieve the ocular itching associated with seasonal allergic conjunctivitis. It was withdrawn from the market in many countries in 1993 following association with haemorrhage and renal failure.. 5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid : A member of the class of pyrrolizines that is 2,3-dihydro-1H-pyrrolizine which is substituted at positions 1 and 5 by carboxy and benzoyl groups, respectively.	4.06	4	0	amino acid; aromatic ketone; monocarboxylic acid; pyrrolizines; racemate	analgesic; cyclooxygenase 1 inhibitor; cyclooxygenase 2 inhibitor; non-steroidal anti-inflammatory drug
labetalol Labetalol: A salicylamide derivative that is a non-cardioselective blocker of BETA-ADRENERGIC RECEPTORS and ALPHA-1 ADRENERGIC RECEPTORS.. labetalol : A diastereoisomeric mixture of approximately equal amounts of all four possible stereoisomers ((R,S)-labetolol, (S,R)-labetolol, (S,S)-labetalol and (R,R)-labetalol). It is an adrenergic antagonist used to treat high blood pressure.. 2-hydroxy-5-{1-hydroxy-2-[(4-phenylbutan-2-yl)amino]ethyl}benzamide : A member of the class of benzamides that is benzamide substituted by a hydroxy group at position 2 and by a 1-hydroxy-2-[(4-phenylbutan-2-yl)amino]ethyl group at position 5.	4.24	5	0	benzamides; benzenes; phenols; primary carboxamide; salicylamides; secondary alcohol; secondary amino compound
lamotrigine [no description available]	3.54	2	0	1,2,4-triazines; dichlorobenzene; primary arylamine	anticonvulsant; antidepressant; antimanic drug; calcium channel blocker; EC 3.4.21.26 (prolyl oligopeptidase) inhibitor; environmental contaminant; excitatory amino acid antagonist; geroprotector; non-narcotic analgesic; xenobiotic
lansoprazole Lansoprazole: A 2,2,2-trifluoroethoxypyridyl derivative of timoprazole that is used in the therapy of STOMACH ULCERS and ZOLLINGER-ELLISON SYNDROME. The drug inhibits H(+)-K(+)-EXCHANGING ATPASE which is found in GASTRIC PARIETAL CELLS. Lansoprazole is a racemic mixture of (R)- and (S)-isomers.	4.06	4	0	benzimidazoles; pyridines; sulfoxide	anti-ulcer drug; EC 3.6.3.10 (H(+)/K(+)-exchanging ATPase) inhibitor
lauric acid dodecanoic acid : A straight-chain, twelve-carbon medium-chain saturated fatty acid with strong bactericidal properties; the main fatty acid in coconut oil and palm kernel oil.	7.31	1	0	medium-chain fatty acid; straight-chain saturated fatty acid	algal metabolite; antibacterial agent; plant metabolite
leflunomide Leflunomide: An isoxazole derivative that inhibits dihydroorotate dehydrogenase, the fourth enzyme in the pyrimidine biosynthetic pathway. It is used an immunosuppressive agent in the treatment of RHEUMATOID ARTHRITIS and PSORIATIC ARTHRITIS.. leflunomide : A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 5-methyl-1,2-oxazole-4-carboxylic acid with the anilino group of 4-(trifluoromethyl)aniline. The prodrug of teriflunomide.	3.23	1	0	(trifluoromethyl)benzenes; isoxazoles; monocarboxylic acid amide	antineoplastic agent; antiparasitic agent; EC 1.3.98.1 [dihydroorotate oxidase (fumarate)] inhibitor; EC 3.1.3.16 (phosphoprotein phosphatase) inhibitor; hepatotoxic agent; immunosuppressive agent; non-steroidal anti-inflammatory drug; prodrug; pyrimidine synthesis inhibitor; tyrosine kinase inhibitor
letrozole [no description available]	3.85	3	0	nitrile; triazoles	antineoplastic agent; EC 1.14.14.14 (aromatase) inhibitor
lofepramine Lofepramine: A psychotropic IMIPRAMINE derivative that acts as a tricyclic antidepressant and possesses few anticholinergic properties. It is metabolized to DESIPRAMINE.	2	1	0	aromatic ketone; dibenzoazepine; monochlorobenzenes; tertiary amino compound	antidepressant
lomefloxacin lomefloxacin: structure given in first source. lomefloxacin : A fluoroquinolone antibiotic, used (generally as the hydrochloride salt) to treat bacterial infections including bronchitis and urinary tract infections. It is also used to prevent urinary tract infections prior to surgery.	3.23	1	0	fluoroquinolone antibiotic; N-arylpiperazine; quinolinemonocarboxylic acid; quinolone antibiotic; quinolone	antimicrobial agent; antitubercular agent; photosensitizing agent
lomustine [no description available]	3.58	2	0	N-nitrosoureas; organochlorine compound	alkylating agent; antineoplastic agent
loperamide Loperamide: One of the long-acting synthetic ANTIDIARRHEALS; it is not significantly absorbed from the gut, and has no effect on the adrenergic system or central nervous system, but may antagonize histamine and interfere with acetylcholine release locally.. loperamide : A synthetic piperidine derivative, effective against diarrhoea resulting from gastroenteritis or inflammatory bowel disease.	3.23	1	0	monocarboxylic acid amide; monochlorobenzenes; piperidines; tertiary alcohol	anticoronaviral agent; antidiarrhoeal drug; mu-opioid receptor agonist
loratadine Loratadine: A second-generation histamine H1 receptor antagonist used in the treatment of allergic rhinitis and urticaria. Unlike most classical antihistamines (HISTAMINE H1 ANTAGONISTS) it lacks central nervous system depressing effects such as drowsiness.. loratadine : A benzocycloheptapyridine that is 6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine substituted by a chloro group at position 8 and a 1-(ethoxycarbonyl)piperidin-4-ylidene group at position 11. It is a H1-receptor antagonist commonly employed in the treatment of allergic disorders.	3.23	1	0	benzocycloheptapyridine; ethyl ester; N-acylpiperidine; organochlorine compound; tertiary carboxamide	anti-allergic agent; cholinergic antagonist; geroprotector; H1-receptor antagonist
lorazepam Lorazepam: A benzodiazepine used as an anti-anxiety agent with few side effects. It also has hypnotic, anticonvulsant, and considerable sedative properties and has been proposed as a preanesthetic agent.	4.06	4	0	benzodiazepine
losartan Losartan: An antagonist of ANGIOTENSIN TYPE 1 RECEPTOR with antihypertensive activity due to the reduced pressor effect of ANGIOTENSIN II.. losartan : A biphenylyltetrazole where a 1,1'-biphenyl group is attached at the 5-position and has an additional trisubstituted imidazol-1-ylmethyl group at the 4'-position	3.85	3	0	biphenylyltetrazole; imidazoles	angiotensin receptor antagonist; anti-arrhythmia drug; antihypertensive agent; endothelin receptor antagonist
loxapine Loxapine: An antipsychotic agent used in SCHIZOPHRENIA.	3.23	1	0	dibenzooxazepine	antipsychotic agent; dopaminergic antagonist
mabuterol mabuterol: structure given in first source	2	1	0	(trifluoromethyl)benzenes
maprotiline Maprotiline: A bridged-ring tetracyclic antidepressant that is both mechanistically and functionally similar to the tricyclic antidepressants, including side effects associated with its use.	3.83	3	0	anthracenes
mebendazole Mebendazole: A benzimidazole that acts by interfering with CARBOHYDRATE METABOLISM and inhibiting polymerization of MICROTUBULES.. mebendazole : A carbamate ester that is methyl 1H-benzimidazol-2-ylcarbamate substituted by a benzoyl group at position 5.	4.06	4	0	aromatic ketone; benzimidazoles; carbamate ester	antinematodal drug; microtubule-destabilising agent; tubulin modulator
mecamylamine Mecamylamine: A nicotinic antagonist that is well absorbed from the gastrointestinal tract and crosses the blood-brain barrier. Mecamylamine has been used as a ganglionic blocker in treating hypertension, but, like most ganglionic blockers, is more often used now as a research tool.	3.23	1	0	primary aliphatic amine
mechlorethamine nitrogen mustard : Compounds having two beta-haloalkyl groups bound to a nitrogen atom, as in (X-CH2-CH2)2NR.	3.58	2	0	nitrogen mustard; organochlorine compound	alkylating agent
meclizine Meclizine: A histamine H1 antagonist used in the treatment of motion sickness, vertigo, and nausea during pregnancy and radiation sickness.	3.23	1	0	diarylmethane
meclofenamic acid Meclofenamic Acid: A non-steroidal anti-inflammatory agent with antipyretic and antigranulation activities. It also inhibits prostaglandin biosynthesis.. meclofenamic acid : An aminobenzoic acid that is anthranilic acid in which one of the hydrogens attached to the nitrogen is replaced by a 2,6-dichloro-3-methylphenyl group. A non-steroidal anti-inflammatory drug, it is used as the sodium salt for the treatment of dysmenorrhoea (painful periods), osteoarthritis and rheumatoid arthritis.	3.23	1	0	aminobenzoic acid; organochlorine compound; secondary amino compound	analgesic; anticonvulsant; antineoplastic agent; antipyretic; antirheumatic drug; EC 1.13.11.34 (arachidonate 5-lipoxygenase) inhibitor; EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor; non-steroidal anti-inflammatory drug
mefenamic acid Mefenamic Acid: A non-steroidal anti-inflammatory agent with analgesic, anti-inflammatory, and antipyretic properties. It is an inhibitor of cyclooxygenase.. mefenamic acid : An aminobenzoic acid that is anthranilic acid in which one of the hydrogens attached to the nitrogen is replaced by a 2,3-dimethylphenyl group. Although classed as a non-steroidal anti-inflammatory drug, its anti-inflammatory properties are considered to be minor. It is used to relieve mild to moderate pain, including headaches, dental pain, osteoarthritis and rheumatoid arthritis.	3.23	1	0	aminobenzoic acid; secondary amino compound	analgesic; antipyretic; antirheumatic drug; EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor; environmental contaminant; non-steroidal anti-inflammatory drug; xenobiotic
memantine [no description available]	3.23	1	0	adamantanes; primary aliphatic amine	antidepressant; antiparkinson drug; dopaminergic agent; neuroprotective agent; NMDA receptor antagonist
vitamin k 3 Vitamin K 3: A synthetic naphthoquinone without the isoprenoid side chain and biological activity, but can be converted to active vitamin K2, menaquinone, after alkylation in vivo.	2.76	3	0	1,4-naphthoquinones; vitamin K	angiogenesis inhibitor; antineoplastic agent; EC 3.4.22.69 (SARS coronavirus main proteinase) inhibitor; human urinary metabolite; nutraceutical
mepenzolate mepenzolic acid: anticholinergic, antispasmodic agent; RN given refers to parent cpd; structure	3.23	1	0	diarylmethane
meperidine Meperidine: A narcotic analgesic that can be used for the relief of most types of moderate to severe pain, including postoperative pain and the pain of labor. Prolonged use may lead to dependence of the morphine type; withdrawal symptoms appear more rapidly than with morphine and are of shorter duration.. pethidine : A piperidinecarboxylate ester that is piperidine which is substituted by a methyl group at position 1 and by phenyl and ethoxycarbonyl groups at position 4. It is an analgesic which is used for the treatment of moderate to severe pain, including postoperative pain and labour pain.	4.06	4	0	ethyl ester; piperidinecarboxylate ester; tertiary amino compound	antispasmodic drug; kappa-opioid receptor agonist; mu-opioid receptor agonist; opioid analgesic
mephenytoin Mephenytoin: An anticonvulsant effective in tonic-clonic epilepsy (EPILEPSY, TONIC-CLONIC). It may cause blood dyscrasias.. mephenytoin : An imidazolidine-2,4-dione (hydantoin) in which the imidazolidine nucleus carries a methyl group at N-3 and has ethyl and phenyl substituents at C-5. An anticonvulsant, it is no longer available in the USA or the UK but is still studied largely because of its interesting hydroxylation polymorphism.	3.58	2	0	imidazolidine-2,4-dione	anticonvulsant
mepivacaine Mepivacaine: A local anesthetic that is chemically related to BUPIVACAINE but pharmacologically related to LIDOCAINE. It is indicated for infiltration, nerve block, and epidural anesthesia. Mepivacaine is effective topically only in large doses and therefore should not be used by this route. (From AMA Drug Evaluations, 1994, p168). mepivacaine : A piperidinecarboxamide in which N-methylpipecolic acid and 2,6-dimethylaniline have combined to form the amide bond. It is used as a local amide-type anaesthetic.	3.85	3	0	piperidinecarboxamide	drug allergen; local anaesthetic
meprobamate Meprobamate: A carbamate with hypnotic, sedative, and some muscle relaxant properties, although in therapeutic doses reduction of anxiety rather than a direct effect may be responsible for muscle relaxation. Meprobamate has been reported to have anticonvulsant actions against petit mal seizures, but not against grand mal seizures (which may be exacerbated). It is used in the treatment of ANXIETY DISORDERS, and also for the short-term management of INSOMNIA but has largely been superseded by the BENZODIAZEPINES. (From Martindale, The Extra Pharmacopoeia, 30th ed, p603)	4.03	4	0	organic molecular entity
mesalamine Mesalamine: An anti-inflammatory agent, structurally related to the SALICYLATES, which is active in INFLAMMATORY BOWEL DISEASE. It is considered to be the active moiety of SULPHASALAZINE. (From Martindale, The Extra Pharmacopoeia, 30th ed). mesalamine : A monohydroxybenzoic acid that is salicylic acid substituted by an amino group at the 5-position.	3.58	2	0	amino acid; aromatic amine; monocarboxylic acid; monohydroxybenzoic acid; phenols	non-steroidal anti-inflammatory drug
mesoridazine Mesoridazine: A phenothiazine antipsychotic with effects similar to CHLORPROMAZINE.. mesoridazine : A phenothiazine substituted at position 2 (para to the S atom) by a methylsulfinyl group, and on the nitrogen by a 2-(1-methylpiperidin-2-yl)ethyl group.	3.23	1	0	phenothiazines; sulfoxide; tertiary amino compound	dopaminergic antagonist; first generation antipsychotic
metaproterenol Metaproterenol: A beta-2 adrenergic agonist used in the treatment of ASTHMA and BRONCHIAL SPASM.. orciprenaline : A racemate composed of equimolar amounts of (R)- and (S)-orciprenaline. Used (as its sulfate salt) to relax the airway muscles and improve breathing for patients suffering from asthma or bronchitis.. 5-[1-hydroxy-2-(isopropanylamino)ethyl]benzene-1,3-diol : A member of the class of resorcinols bearing an additional 1-hydroxy-2-(isopropanylamino)ethyl substituent at position 5 of resorcinol itself.	3.54	2	0	aralkylamino compound; phenylethanolamines; resorcinols; secondary alcohol; secondary amino compound
metformin Metformin: A biguanide hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification. Metformin improves glycemic control by improving insulin sensitivity and decreasing intestinal absorption of glucose. (From Martindale, The Extra Pharmacopoeia, 30th ed, p289). metformin : A member of the class of guanidines that is biguanide the carrying two methyl substituents at position 1.	3.85	3	0	guanidines	environmental contaminant; geroprotector; hypoglycemic agent; xenobiotic
methacrylic acid methacrylic acid: RN given refers to parent cpd. methacrylic acid : An alpha,beta-unsaturated monocarboxylic acid that is acrylic acid in which the hydrogen at position 2 is substituted by a methyl group.	2.15	1	0	alpha,beta-unsaturated monocarboxylic acid
methadone Methadone: A synthetic opioid that is used as the hydrochloride. It is an opioid analgesic that is primarily a mu-opioid agonist. It has actions and uses similar to those of MORPHINE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1082-3). methadone : A racemate comprising equimolar amounts of dextromethadone and levomethadone. It is a opioid analgesic which is used as a painkiller and as a substitute for heroin in the treatment of heroin addiction.. 6-(dimethylamino)-4,4-diphenylheptan-3-one : A ketone that is heptan-3-one substituted by a dimethylamino group at position 6 and two phenyl groups at position 4.	4.06	4	0	benzenes; diarylmethane; ketone; tertiary amino compound
methapyrilene Methapyrilene: Histamine H1 antagonist with sedative action used as a hypnotic and in allergies.. methapyrilene : A member of the class of ethylenediamine derivatives that is ethylenediamine in which one of the nitrogens is substituted by two methyl groups, and the other nitrogen is substituted by a 2-pyridyl group and a (2-thienyl)methyl group.	2.04	1	0	ethylenediamine derivative	anti-allergic agent; carcinogenic agent; H1-receptor antagonist; sedative
methazolamide Methazolamide: A carbonic anhydrase inhibitor that is used as a diuretic and in the treatment of glaucoma.	3.23	1	0	sulfonamide; thiadiazoles
methenamine Methenamine: An anti-infective agent most commonly used in the treatment of urinary tract infections. Its anti-infective action derives from the slow release of formaldehyde by hydrolysis at acidic pH. (From Martindale, The Extra Pharmacopoeia, 30th ed, p173). hexamethylenetetramine : A polycyclic cage that is adamantane in which the carbon atoms at positions 1, 3, 5 and 7 are replaced by nitrogen atoms.	1.94	1	0	polyazaalkane; polycyclic cage; tetramine	antibacterial drug
methocarbamol Methocarbamol: A centrally acting muscle relaxant whose mode of action has not been established. It is used as an adjunct in the symptomatic treatment of musculoskeletal conditions associated with painful muscle spasm. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1206). methocarbamol : A racemate comprising equimolar amounts of (R)- and (S)-methocarbamol. A centrally acting skeletal muscle relaxant, it is used as an adjunct in the short-term symptomatic treatment of painful muscle spasm. The (R)-enantiomer is more active than the (S)-enantiomer.. 2-hydroxy-3-(2-methoxyphenoxy)propyl carbamate : A carbamate ester that is glycerol in which one of the primary alcohol groups has been converted to its 2-methoxyphenyl ether while the other has been converted to the corresponding carbamate ester.	3.23	1	0	aromatic ether; carbamate ester; secondary alcohol
methoxsalen Methoxsalen: A naturally occurring furocoumarin compound found in several species of plants, including Psoralea corylifolia. It is a photoactive substance that forms DNA ADDUCTS in the presence of ultraviolet A irradiation.. methoxsalen : A member of the class of psoralens that is 7H-furo[3,2-g]chromen-7-one in which the 9 position is substituted by a methoxy group. It is a constituent of the fruits of Ammi majus. Like other psoralens, trioxsalen causes photosensitization of the skin. It is administered topically or orally in conjunction with UV-A for phototherapy treatment of vitiligo and severe psoriasis.	3.23	1	0	aromatic ether; psoralens	antineoplastic agent; cross-linking reagent; dermatologic drug; photosensitizing agent; plant metabolite
methoxyflurane Methoxyflurane: An inhalation anesthetic. Currently, methoxyflurane is rarely used for surgical, obstetric, or dental anesthesia. If so employed, it should be administered with NITROUS OXIDE to achieve a relatively light level of anesthesia, and a neuromuscular blocking agent given concurrently to obtain the desired degree of muscular relaxation. (From AMA Drug Evaluations Annual, 1994, p180). methoxyflurane : An ether in which the two groups attached to the central oxygen atom are methyl and 2,2-dichloro-1,1-difluoroethyl.	2.04	1	0	ether; organochlorine compound; organofluorine compound	hepatotoxic agent; inhalation anaesthetic; nephrotoxic agent; non-narcotic analgesic
methyclothiazide Methyclothiazide: A thiazide diuretic with properties similar to those of HYDROCHLOROTHIAZIDE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p825)	3.58	2	0	benzothiadiazine
nocodazole [no description available]	2.48	2	0	aromatic ketone; benzimidazoles; carbamate ester; thiophenes	antimitotic; antineoplastic agent; microtubule-destabilising agent; tubulin modulator
methyl salicylate methyl salicylate: used in over-the-counter liniments, ointments, lotions for relief of musculoskeletal aches and pains; has hemolytic effect on human & sheep erythrocytes; RN given refers to parent cpd; structure in Merck Index, 9th ed, #5990. methyl salicylate : A benzoate ester that is the methyl ester of salicylic acid.	2.04	1	0	benzoate ester; methyl ester; salicylates	flavouring agent; insect attractant; metabolite
methylphenidate Methylphenidate: A central nervous system stimulant used most commonly in the treatment of ATTENTION DEFICIT DISORDER in children and for NARCOLEPSY. Its mechanisms appear to be similar to those of DEXTROAMPHETAMINE. The d-isomer of this drug is referred to as DEXMETHYLPHENIDATE HYDROCHLORIDE.. methylphenidate : A racemate comprising equimolar amounts of the two threo isomers of methyl phenyl(piperidin-2-yl)acetate. A central stimulant and indirect-acting sympathomimetic, is used (generally as the hydrochloride salt) in the treatment of hyperactivity disorders in children and for the treatment of narcolepsy.. methyl phenyl(piperidin-2-yl)acetate : A amino acid ester that is methyl phenylacetate in which one of the hydrogens alpha to the carbonyl group is replaced by a piperidin-2-yl group.	4.07	4	0	beta-amino acid ester; methyl ester; piperidines
metoclopramide Metoclopramide: A dopamine D2 antagonist that is used as an antiemetic.. metoclopramide : A member of the class of benzamides resulting from the formal condensation of 4-amino-5-chloro-2-methoxybenzoic acid with the primary amino group of N,N-diethylethane-1,2-diamine.	4.24	5	0	benzamides; monochlorobenzenes; substituted aniline; tertiary amino compound	antiemetic; dopaminergic antagonist; environmental contaminant; gastrointestinal drug; xenobiotic
metolazone Metolazone: A quinazoline-sulfonamide derived DIURETIC that functions by inhibiting SODIUM CHLORIDE SYMPORTERS.. metolazone : A quinazoline that consists of 1,2,3,4-tetrahydroquinazolin-4-one bearing additional methyl, 2-tolyl, sulfamyl and chloro substituents at positions 2, 3, 6 and 7 respectively. A quinazoline diuretic, with properties similar to thiazide diuretics.	3.85	3	0	organochlorine compound; quinazolines; sulfonamide	antihypertensive agent; diuretic; ion transport inhibitor
metoprolol Metoprolol: A selective adrenergic beta-1 blocking agent that is commonly used to treat ANGINA PECTORIS; HYPERTENSION; and CARDIAC ARRHYTHMIAS.. metoprolol : A propanolamine that is 1-(propan-2-ylamino)propan-2-ol substituted by a 4-(2-methoxyethyl)phenoxy group at position 1.	4.06	4	0	aromatic ether; propanolamine; secondary alcohol; secondary amino compound	antihypertensive agent; beta-adrenergic antagonist; environmental contaminant; geroprotector; xenobiotic
metronidazole Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.. metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.	11.72	17	1	C-nitro compound; imidazoles; primary alcohol	antiamoebic agent; antibacterial drug; antimicrobial agent; antiparasitic agent; antitrichomonal drug; environmental contaminant; prodrug; radiosensitizing agent; xenobiotic
metyrapone Metyrapone: An inhibitor of the enzyme STEROID 11-BETA-MONOOXYGENASE. It is used as a test of the feedback hypothalamic-pituitary mechanism in the diagnosis of CUSHING SYNDROME.. metyrapone : An aromatic ketone that is 3,3-dimethylbutan-2-one in which the methyl groups at positions 1 and 4 are replaced by pyridin-3-yl groups. A steroid 11beta-monooxygenase (EC 1.14.15.4) inhibitor, it is used in the diagnosis of adrenal insufficiency.	3.48	2	0	aromatic ketone	antimetabolite; diagnostic agent; EC 1.14.15.4 (steroid 11beta-monooxygenase) inhibitor
mexiletine Mexiletine: Antiarrhythmic agent pharmacologically similar to LIDOCAINE. It may have some anticonvulsant properties.. mexiletine : An aromatic ether which is 2,6-dimethylphenyl ether of 2-aminopropan-1-ol.	4.24	5	0	aromatic ether; primary amino compound	anti-arrhythmia drug
mianserin Mianserin: A tetracyclic compound with antidepressant effects. It may cause drowsiness and hematological problems. Its mechanism of therapeutic action is not well understood, although it apparently blocks alpha-adrenergic, histamine H1, and some types of serotonin receptors.. mianserin : A dibenzoazepine (specifically 1,2,3,4,10,14b-hexahydrodibenzo[c,f]pyrazino[1,2-a]azepine) methyl-substituted on N-2. Closely related to (and now mostly superseded by) the tetracyclic antidepressant mirtazapinean, it is an atypical antidepressant used in the treatment of depression throughout Europe and elsewhere.	2	1	0	dibenzoazepine	adrenergic uptake inhibitor; alpha-adrenergic antagonist; antidepressant; EC 3.4.21.26 (prolyl oligopeptidase) inhibitor; geroprotector; H1-receptor antagonist; histamine agonist; sedative; serotonergic antagonist
miconazole Miconazole: An imidazole antifungal agent that is used topically and by intravenous infusion.. 1-[2-(2,4-dichlorobenzyloxy)-2-(2,4-dichlorophenyl)ethyl]imidazole : A member of the class of imidazoles that is 1-(2,4-dichlorophenyl)-2-(imidazol-1-yl)ethanol in which the hydroxyl hydrogen is replaced by a 2,4-dichlorobenzyl group.. miconazole : A racemate composed of equimolar amounts of (R)- and (S)-miconazole. Used (as its nitrate salt) to treat skin infections such as athlete's foot, jock itch, ringworm and other fungal skin infections. It inhibits the synthesis of ergosterol, a critical component of fungal cell membranes.	2.15	1	0	dichlorobenzene; ether; imidazoles
midazolam Midazolam: A short-acting hypnotic-sedative drug with anxiolytic and amnestic properties. It is used in dentistry, cardiac surgery, endoscopic procedures, as preanesthetic medication, and as an adjunct to local anesthesia. The short duration and cardiorespiratory stability makes it useful in poor-risk, elderly, and cardiac patients. It is water-soluble at pH less than 4 and lipid-soluble at physiological pH.. midazolam : An imidazobenzodiazepine that is 4H-imidazo[1,5-a][1,4]benzodiazepine which is substituted by a methyl, 2-fluorophenyl and chloro groups at positions 1, 6 and 8, respectively.	4.06	4	0	imidazobenzodiazepine; monofluorobenzenes; organochlorine compound	anticonvulsant; antineoplastic agent; anxiolytic drug; apoptosis inducer; central nervous system depressant; GABAA receptor agonist; general anaesthetic; muscle relaxant; sedative
midodrine Midodrine: An ethanolamine derivative that is an adrenergic alpha-1 agonist. It is used as a vasoconstrictor agent in the treatment of HYPOTENSION.. midodrine : An aromatic ether that is 1,4-dimethoxybenzene which is substituted at position 2 by a 2-(glycylamino)-1-hydroxyethyl group. A direct-acting sympathomimetic with selective alpha-adrenergic agonist activity, it is used (generally as its hydrochloride salt) as a peripheral vasoconstrictor in the treatment of certain hypotensive states. The main active moiety is its major metabolite, deglymidodrine.	3.23	1	0	amino acid amide; aromatic ether; secondary alcohol	alpha-adrenergic agonist; prodrug; sympathomimetic agent; vasoconstrictor agent
milrinone [no description available]	4.06	4	0	bipyridines; nitrile; pyridone	cardiotonic drug; EC 3.1.4.17 (3',5'-cyclic-nucleotide phosphodiesterase) inhibitor; platelet aggregation inhibitor; vasodilator agent
minoxidil Minoxidil: A potent direct-acting peripheral vasodilator (VASODILATOR AGENTS) that reduces peripheral resistance and produces a fall in BLOOD PRESSURE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p371). minoxidil : A pyrimidine N-oxide that is pyrimidine-2,4-diamine 3-oxide substituted by a piperidin-1-yl group at position 6.	3.58	2	0	dialkylarylamine; tertiary amino compound
mirtazapine Mirtazapine: A piperazinoazepine tetracyclic compound that enhances the release of NOREPINEPHRINE and SEROTONIN through blockage of presynaptic ALPHA-2 ADRENERGIC RECEPTORS. It also blocks both 5-HT2 and 5-HT3 serotonin receptors and is a potent HISTAMINE H1 RECEPTOR antagonist. It is used for the treatment of depression, and may also be useful for the treatment of anxiety disorders.	4.06	4	0	benzazepine; tetracyclic antidepressant	alpha-adrenergic antagonist; anxiolytic drug; H1-receptor antagonist; histamine antagonist; oneirogen; serotonergic antagonist
mitotane Mitotane: A derivative of the insecticide DICHLORODIPHENYLDICHLOROETHANE that specifically inhibits cells of the adrenal cortex and their production of hormones. It is used to treat adrenocortical tumors and causes CNS damage, but no bone marrow depression.	3.23	1	0	diarylmethane
mitoxantrone Mitoxantrone: An anthracenedione-derived antineoplastic agent.. mitoxantrone : A dihydroxyanthraquinone that is 1,4-dihydroxy-9,10-anthraquinone which is substituted by 6-hydroxy-1,4-diazahexyl groups at positions 5 and 8.	4.07	4	0	dihydroxyanthraquinone	analgesic; antineoplastic agent
moclobemide Moclobemide: A reversible inhibitor of monoamine oxidase type A; (RIMA); (see MONOAMINE OXIDASE INHIBITORS) that has antidepressive properties.. moclobemide : A member of the class of benzamides that is benzamide substituted by a chloro group at position 4 and a 2-(morpholin-4-yl)ethyl group at the nitrogen atom. It acts as a reversible monoamine oxidase inhibitor and is used in the treatment of depression.	2.94	4	0	benzamides; monochlorobenzenes; morpholines	antidepressant; environmental contaminant; xenobiotic
modafinil Modafinil: A benzhydryl acetamide compound, central nervous system stimulant, and CYP3A4 inducing agent that is used in the treatment of NARCOLEPSY and SLEEP WAKE DISORDERS.. modafinil : A racemate comprising equimolar amounts of armodafinil and (S)-modafinil. A central nervous system stimulant, it is used for the treatment of sleeping disorders such as narcolepsy, obstructive sleep apnoea, and shift-work sleep disorder. The optical enantiomers of modafinil have similar pharmacological actions in animals.. 2-[(diphenylmethyl)sulfinyl]acetamide : A sulfoxide that is dimethylsulfoxide in which two hydrogens attached to one of the methyl groups are replaced by phenyl groups, while one hydrogen attached to the other methyl group is replaced by a carbamoyl (aminocarbonyl) group.	3.23	1	0	monocarboxylic acid amide; sulfoxide
moxisylyte Moxisylyte: An alpha-adrenergic blocking agent that is used in Raynaud's disease. It is also used locally in the eye to reverse the mydriasis caused by phenylephrine and other sympathomimetic agents. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1312)	3.23	1	0	monoterpenoid
acecainide Acecainide: A major metabolite of PROCAINAMIDE. Its anti-arrhythmic action may cause cardiac toxicity in kidney failure.. N-acetylprocainamide : A benzamide obtained via formal condensation of 4-acetamidobenzoic acid and 2-(diethylamino)ethylamine.	2.45	2	0	acetamides; benzamides	anti-arrhythmia drug
clorgyline Clorgyline: An antidepressive agent and monoamine oxidase inhibitor related to PARGYLINE.. clorgyline : An aromatic ether that is the 2,4-dichlorophenyl ether of 3-aminopropan-1-ol in which the nitrogen is substituted by a methyl group and a prop-1-yn-3-yl group. A monoamine oxidase inhibitor, it was formerly used as an antidepressant.	2.04	1	0	aromatic ether; dichlorobenzene; terminal acetylenic compound; tertiary amino compound	antidepressant; EC 1.4.3.4 (monoamine oxidase) inhibitor
deoxyepinephrine Deoxyepinephrine: Sympathomimetic, vasoconstrictor agent.	3.06	1	0	catecholamine
nabumetone Nabumetone: A butanone non-steroidal anti-inflammatory drug and cyclooxygenase-2 (COX2) inhibitor that is used in the management of pain associated with OSTEOARTHRITIS and RHEUMATOID ARTHRITIS.. nabumetone : A methyl ketone that is 2-butanone in which one of the methyl hydrogens at position 4 is replaced by a 6-methoxy-2-naphthyl group. A prodrug that is converted to the active metabolite, 6-methoxy-2-naphthylacetic acid, following oral administration. It is shown to have a slightly lower risk of gastrointestinal side effects than most other non-steroidal anti-inflammatory drugs.	3.54	2	0	methoxynaphthalene; methyl ketone	cyclooxygenase 2 inhibitor; non-narcotic analgesic; non-steroidal anti-inflammatory drug; prodrug
nadolol [no description available]	3.23	1	0	tetralins
nalidixic acid [no description available]	7.13	16	1	1,8-naphthyridine derivative; monocarboxylic acid; quinolone antibiotic	antibacterial drug; antimicrobial agent; DNA synthesis inhibitor
naratriptan naratriptan: structure given in first source	3.85	3	0	heteroarylpiperidine; sulfonamide; tryptamines	serotonergic agonist; vasoconstrictor agent
nefazodone nefazodone: may be useful as an opiate adjunct	3.85	3	0	aromatic ether; monochlorobenzenes; N-alkylpiperazine; N-arylpiperazine; triazoles	alpha-adrenergic antagonist; analgesic; antidepressant; serotonergic antagonist; serotonin uptake inhibitor
nefopam Nefopam: Non-narcotic analgesic chemically similar to ORPHENADRINE. Its mechanism of action is unclear. It is used for the relief of acute and chronic pain. (From Martindale, The Extra Pharmacopoeia, 30th ed, p26). nefopam : A racemate comprising equal amounts of (R)- and (S)-nefopam. The hydrochloride is a centrally acting non-opiate analgesic commonly used for the treatment of moderate to severe pain.. 5-methyl-1-phenyl-3,4,5,6-tetrahydro-1H-2,5-benzoxazocine : A member of the class of benzoxazocines that is 3,4,5,6-tetrahydro-1H-2,5-benzoxazocine substituted by phenyl and methyl groups at positions 1 and 5 respectively.	2.04	1	0	benzoxazocine; tertiary amino compound
nevirapine Nevirapine: A potent, non-nucleoside reverse transcriptase inhibitor used in combination with nucleoside analogues for treatment of HIV INFECTIONS and AIDS.. nevirapine : A dipyridodiazepine that is 5,11-dihydro-6H-dipyrido[3,2-b:2',3'-e][1,4]diazepine which is substituted by methyl, oxo, and cyclopropyl groups at positions 4, 6, and 11, respectively. A non-nucleoside reverse transcriptase inhibitor with activity against HIV-1, it is used in combination with other antiretrovirals for the treatment of HIV infection.	4.06	4	0	cyclopropanes; dipyridodiazepine	antiviral drug; HIV-1 reverse transcriptase inhibitor
nialamide Nialamide: An MAO inhibitor that is used as an antidepressive agent.	3.23	1	0	organonitrogen compound; organooxygen compound
nicardipine Nicardipine: A potent calcium channel blockader with marked vasodilator action. It has antihypertensive properties and is effective in the treatment of angina and coronary spasms without showing cardiodepressant effects. It has also been used in the treatment of asthma and enhances the action of specific antineoplastic agents.. nicardipine : A racemate comprising equimolar amounts of (R)- and (S)-nicardipine. It is a calcium channel blocker which is used to treat hypertension.. 2-[benzyl(methyl)amino]ethyl methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate : A dihydropyridine that is 1,4-dihydropyridine substituted by a methyl, {2-[benzyl(methyl)amino]ethoxy}carbonyl, 3-nitrophenyl, methoxycarbonyl and methyl groups at positions 2, 3, 4, 5 and 6, respectively.	4.06	4	0	benzenes; C-nitro compound; diester; dihydropyridine; methyl ester; tertiary amino compound
nifedipine Nifedipine: A potent vasodilator agent with calcium antagonistic action. It is a useful anti-anginal agent that also lowers blood pressure.	4.37	6	0	C-nitro compound; dihydropyridine; methyl ester	calcium channel blocker; human metabolite; tocolytic agent; vasodilator agent
nilutamide [no description available]	3.23	1	0	(trifluoromethyl)benzenes; C-nitro compound; imidazolidinone	androgen antagonist; antineoplastic agent
nilvadipine [no description available]	2	1	0	dihydropyridine; isopropyl ester; methyl ester; nitrile
nimesulide nimesulide: structure. nimesulide : An aromatic ether having phenyl and 2-methylsulfonamido-5-nitrophenyl as the two aryl groups.	3.23	1	0	aromatic ether; C-nitro compound; sulfonamide	cyclooxygenase 2 inhibitor; non-steroidal anti-inflammatory drug
nimodipine Nimodipine: A calcium channel blockader with preferential cerebrovascular activity. It has marked cerebrovascular dilating effects and lowers blood pressure.. nimodipine : A dihydropyridine that is 1,4-dihydropyridine which is substituted by methyl groups at positions 2 and 6, a (2-methoxyethoxy)carbonyl group at position 3, a m-nitrophenyl group at position 4, and an isopropoxycarbonyl group at position 5. An L-type calcium channel blocker, it acts particularly on cerebral circulation, and is used both orally and intravenously for the prevention and treatment of subarachnoid hemorrhage from ruptured intracranial aneurysm.	4.24	5	0	2-methoxyethyl ester; C-nitro compound; dicarboxylic acids and O-substituted derivatives; diester; dihydropyridine; isopropyl ester	antihypertensive agent; calcium channel blocker; cardiovascular drug; vasodilator agent
nisoldipine Nisoldipine: A dihydropyridine calcium channel antagonist that acts as a potent arterial vasodilator and antihypertensive agent. It is also effective in patients with cardiac failure and angina.. nisoldipine : A racemate consisting of equimolar amounts of (R)- and (S)-nisoldipine. A calcium channel blocker, it is used in the treatment of hypertension and angina pectoris.. methyl 2-methylpropyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate : A dihydropyridine that is 1,4-dihydropyridine which is substituted by methyl groups at positions 2 and 6, a methoxycarbonyl group at position 3, an o-nitrophenyl group at position 4, and an isobutoxycarbonyl group at position 5. The racemate, a calcium channel blocker, is used in the treatment of hypertension and angina pectoris.	4.06	4	0	C-nitro compound; dicarboxylic acids and O-substituted derivatives; diester; dihydropyridine; methyl ester
nitrazepam Nitrazepam: A benzodiazepine derivative used as an anticonvulsant and hypnotic.. nitrazepam : A 1,4-benzodiazepinone that is 1,3-dihydro-2H-1,4-benzodiazepin-2-one which is substituted at positions 5 and 7 by phenyl and nitro groups, respectively. It is used as a hypnotic for the short-term management of insomnia and for the treatment of epileptic spasms in infants (West's syndrome).	2.72	3	0	1,4-benzodiazepinone; C-nitro compound	anticonvulsant; antispasmodic drug; drug metabolite; GABA modulator; sedative
nitrendipine Nitrendipine: A calcium channel blocker with marked vasodilator action. It is an effective antihypertensive agent and differs from other calcium channel blockers in that it does not reduce glomerular filtration rate and is mildly natriuretic, rather than sodium retentive.. nitrendipine : A dihydropyridine that is 1,4-dihydropyridine substituted by methyl groups at positions 2 and 6, a 3-nitrophenyl group at position 4, a ethoxycarbonyl group at position 3 and a methoxycarbonyl group at position 5. It is a calcium-channel blocker used in the treatment of hypertension.	2.94	4	0	C-nitro compound; dicarboxylic acids and O-substituted derivatives; diester; dihydropyridine; ethyl ester; methyl ester	antihypertensive agent; calcium channel blocker; geroprotector; vasodilator agent
nitroglycerin Nitroglycerin: A volatile vasodilator which relieves ANGINA PECTORIS by stimulating GUANYLATE CYCLASE and lowering cytosolic calcium. It is also sometimes used for TOCOLYSIS and explosives.. nitroglycerol : A nitrate ester that is glycerol in which nitro group(s) replace the hydrogen(s) attached to one or more of the hydroxy groups.. nitroglycerin : A nitroglycerol that is glycerol in which the hydrogen atoms of all three hydroxy groups are replaced by nitro groups. It acts as a prodrug, releasing nitric oxide to open blood vessels and so alleviate heart pain.	3.58	2	0	nitroglycerol	explosive; muscle relaxant; nitric oxide donor; prodrug; tocolytic agent; vasodilator agent; xenobiotic
nizatidine [no description available]	4.06	4	0	1,3-thiazoles; C-nitro compound; carboxamidine; organic sulfide; tertiary amino compound	anti-ulcer drug; cholinergic drug; H2-receptor antagonist
nomifensine Nomifensine: An isoquinoline derivative that prevents dopamine reuptake into synaptosomes. The maleate was formerly used in the treatment of depression. It was withdrawn worldwide in 1986 due to the risk of acute hemolytic anemia with intravascular hemolysis resulting from its use. In some cases, renal failure also developed. (From Martindale, The Extra Pharmacopoeia, 30th ed, p266). nomifensine : An N-methylated tetrahydroisoquinoline carrying phenyl and amino substituents at positions C-4 and C-8, respectively.	3.85	3	0	isoquinolines	dopamine uptake inhibitor
norfloxacin Norfloxacin: A synthetic fluoroquinolone (FLUOROQUINOLONES) with broad-spectrum antibacterial activity against most gram-negative and gram-positive bacteria. Norfloxacin inhibits bacterial DNA GYRASE.. norfloxacin : A quinolinemonocarboxylic acid with broad-spectrum antibacterial activity against most gram-negative and gram-positive bacteria. Norfloxacin is bactericidal and its mode of action depends on blocking of bacterial DNA replication by binding itself to an enzyme called DNA gyrase.	11.77	31	0	fluoroquinolone antibiotic; N-arylpiperazine; quinolinemonocarboxylic acid; quinolone antibiotic; quinolone	antibacterial drug; DNA synthesis inhibitor; environmental contaminant; xenobiotic
nortriptyline Nortriptyline: A metabolite of AMITRIPTYLINE that is also used as an antidepressive agent. Nortriptyline is used in major depression, dysthymia, and atypical depressions.. nortriptyline : An organic tricyclic compound that is 10,11-dihydro-5H-dibenzo[a,d][7]annulene substituted by a 3-(methylamino)propylidene group at position 5. It is an active metabolite of amitriptyline.	4.06	4	0	organic tricyclic compound; secondary amine	adrenergic uptake inhibitor; analgesic; antidepressant; antineoplastic agent; apoptosis inducer; drug metabolite
nylidrin Nylidrin: A beta-adrenergic agonist. Nylidrin causes peripheral vasodilation, a positive inotropic effect, and increased gastric volume of gastric juice. It is used in the treatment of peripheral vascular disorders and premature labor.	2.04	1	0	alkylbenzene
ofloxacin Ofloxacin: A synthetic fluoroquinolone antibacterial agent that inhibits the supercoiling activity of bacterial DNA GYRASE, halting DNA REPLICATION.. 9-fluoro-3-methyl-10-(4-methylpiperazin-1-yl)-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid : An oxazinoquinoline that is 2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinolin-7-one substituted by methyl, carboxy, fluoro, and 4-methylpiperazin-1-yl groups at positions 3, 6, 9, and 10, respectively.. ofloxacin : A racemate comprising equimolar amounts of levofloxacin and dextrofloxacin. It is a synthetic fluoroquinolone antibacterial agent which inhibits the supercoiling activity of bacterial DNA gyrase, halting DNA replication.	7.2	29	1	3-oxo monocarboxylic acid; N-arylpiperazine; N-methylpiperazine; organofluorine compound; oxazinoquinoline
omeprazole Omeprazole: A 4-methoxy-3,5-dimethylpyridyl, 5-methoxybenzimidazole derivative of timoprazole that is used in the therapy of STOMACH ULCERS and ZOLLINGER-ELLISON SYNDROME. The drug inhibits an H(+)-K(+)-EXCHANGING ATPASE which is found in GASTRIC PARIETAL CELLS.. omeprazole : A racemate comprising equimolar amounts of (R)- and (S)-omeprazole.. 5-methoxy-2-{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl}-1H-benzimidazole : A member of the class of benzimidazoles that is 1H-benzimidazole which is substituted by a [4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl group at position 2 and a methoxy group at position 5.	4.06	4	0	aromatic ether; benzimidazoles; pyridines; sulfoxide
ondansetron Ondansetron: A competitive serotonin type 3 receptor antagonist. It is effective in the treatment of nausea and vomiting caused by cytotoxic chemotherapy drugs, including cisplatin, and has reported anxiolytic and neuroleptic properties.	3.83	3	0	carbazoles
orphenadrine Orphenadrine: A muscarinic antagonist used to treat drug-induced parkinsonism and to relieve pain from muscle spasm.. orphenadrine : A tertiary amino compound which is the phenyl-o-tolylmethyl ether of 2-(dimethylamino)ethanol.	3.23	1	0	ether; tertiary amino compound	antidyskinesia agent; antiparkinson drug; H1-receptor antagonist; muscarinic antagonist; muscle relaxant; NMDA receptor antagonist; parasympatholytic
oxaprozin Oxaprozin: An oxazole-propionic acid derivative, cyclooxygenase inhibitor, and non-steroidal anti-inflammatory drug that is used in the treatment of pain and inflammation associated with of OSTEOARTHRITIS; RHEUMATOID ARTHRITIS; and ARTHRITIS, JUVENILE.. oxaprozin : A monocarboxylic acid that is a propionic acid derivative having a 4,5-diphenyl-1,3-oxazol-2-yl substituent at position 3. It is non-steroidal anti-inflammatory drug commonly used to relieve the pain and inflammatory responses associated with osteoarthritis and rheumatoid arthritis.	3.54	2	0	1,3-oxazoles; monocarboxylic acid	analgesic; non-steroidal anti-inflammatory drug
oxazepam Oxazepam: A benzodiazepine used in the treatment of anxiety, alcohol withdrawal, and insomnia.. oxazepam : A 1,4-benzodiazepinone that is 1,3-dihydro-2H-1,4-benzodiazepin-2-one substituted by a chloro group at position 7, a hydroxy group at position 3 and phenyl group at position 5.	4.06	4	0	1,4-benzodiazepinone; organochlorine compound	anxiolytic drug; environmental contaminant; xenobiotic
oxiracetam oxiracetam: structure in first source	2.04	1	0	organonitrogen compound; organooxygen compound
oxprenolol Oxprenolol: A beta-adrenergic antagonist used in the treatment of hypertension, angina pectoris, arrhythmias, and anxiety.	2.42	2	0	aromatic ether
oxybutynin oxybutynin: RN given refers to parent cpd. oxybutynin : A racemate comprising equimolar amounts of (R)-oxybutynin and esoxybutynin. An antispasmodic used for the treatment of overactive bladder.	3.58	2	0	acetylenic compound; carboxylic ester; racemate; tertiary alcohol; tertiary amino compound	antispasmodic drug; calcium channel blocker; local anaesthetic; muscarinic antagonist; muscle relaxant; parasympatholytic
aminosalicylic acid Aminosalicylic Acid: An antitubercular agent often administered in association with ISONIAZID. The sodium salt of the drug is better tolerated than the free acid.. 4-aminosalicylic acid : An aminobenzoic acid that is salicylic acid substituted by an amino group at position 4.	3.23	1	0	aminobenzoic acid; phenols	antitubercular agent
pamidronate [no description available]	3.58	2	0	phosphonoacetic acid
pantoprazole Pantoprazole: 2-pyridinylmethylsulfinylbenzimidazole proton pump inhibitor that is used in the treatment of GASTROESOPHAGEAL REFLUX and PEPTIC ULCER.. pantoprazole : A member of the class of benzimidazoles that is 1H-benzimidazole substituted by a difluoromethoxy group at position 5 and a [(3,4-dimethoxypyridin-2-yl)methyl]sulfinyl group at position 2.	3.85	3	0	aromatic ether; benzimidazoles; organofluorine compound; pyridines; sulfoxide	anti-ulcer drug; EC 3.6.3.10 (H(+)/K(+)-exchanging ATPase) inhibitor; environmental contaminant; xenobiotic
papaverine Papaverine: An alkaloid found in opium but not closely related to the other opium alkaloids in its structure or pharmacological actions. It is a direct-acting smooth muscle relaxant used in the treatment of impotence and as a vasodilator, especially for cerebral vasodilation. The mechanism of its pharmacological actions is not clear, but it apparently can inhibit phosphodiesterases and it may have direct actions on calcium channels.. papaverine : A benzylisoquinoline alkaloid that is isoquinoline substituted by methoxy groups at positions 6 and 7 and a 3,4-dimethoxybenzyl group at position 1. It has been isolated from Papaver somniferum.	3.85	3	0	benzylisoquinoline alkaloid; dimethoxybenzene; isoquinolines	antispasmodic drug; vasodilator agent
4-dichlorobenzene dichlorobenzene : Any member of the class of chlorobenzenes carrying two chloro groups at unspecified positions.. 1,4-dichlorobenzene : A dichlorobenzene carrying chloro groups at positions 1 and 4.	2.04	1	0	dichlorobenzene	insecticide
pemoline Pemoline: A central nervous system stimulant used in fatigue and depressive states and to treat hyperkinetic disorders in children.. pemoline : A member of the class of 1,3-oxazoles that is 1,3-oxazol-4(5H)-one which is substituted by an amino group at position 2 and by a phenyl group at position 5. A central nervous system stimulant, it was used to treat hyperactivity disorders in children, but withdrawn from use following reports of serious hepatotoxicity.	3.23	1	0	1,3-oxazoles	central nervous system stimulant
pentamidine Pentamidine: Antiprotozoal agent effective in trypanosomiasis, leishmaniasis, and some fungal infections; used in treatment of PNEUMOCYSTIS pneumonia in HIV-infected patients. It may cause diabetes mellitus, central nervous system damage, and other toxic effects.. pentamidine : A diether consisting of pentane-1,5-diol in which both hydroxyl hydrogens have been replaced by 4-amidinophenyl groups. A trypanocidal drug that is used for treatment of cutaneous leishmaniasis and Chagas disease.	4.09	4	0	aromatic ether; carboxamidine; diether	anti-inflammatory agent; antifungal agent; calmodulin antagonist; chemokine receptor 5 antagonist; EC 2.3.1.48 (histone acetyltransferase) inhibitor; NMDA receptor antagonist; S100 calcium-binding protein B inhibitor; trypanocidal drug; xenobiotic
pentobarbital Pentobarbital: A short-acting barbiturate that is effective as a sedative and hypnotic (but not as an anti-anxiety) agent and is usually given orally. It is prescribed more frequently for sleep induction than for sedation but, like similar agents, may lose its effectiveness by the second week of continued administration. (From AMA Drug Evaluations Annual, 1994, p236). pentobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and sec-pentyl groups.	8.83	3	0	barbiturates	GABAA receptor agonist
pentoxifylline [no description available]	3.83	3	0	oxopurine
perhexiline Perhexiline: 2-(2,2-Dicyclohexylethyl)piperidine. Coronary vasodilator used especially for angina of effort. It may cause neuropathy and hepatitis.	4.01	2	0	piperidines	cardiovascular drug
perphenazine Perphenazine: An antipsychotic phenothiazine derivative with actions and uses similar to those of CHLORPROMAZINE.. perphenazine : A phenothiazine derivative in which the phenothiazine tricycle carries a chloro substituent at the 2-position and a 3-[4-(2-hydroxyethyl)piperazin-1-yl]propyl group at N-10.	4.24	5	0	N-(2-hydroxyethyl)piperazine; N-alkylpiperazine; organochlorine compound; phenothiazines	antiemetic; dopaminergic antagonist; phenothiazine antipsychotic drug
phenacemide phenacemide: anti-epileptic drug; structure	2.04	1	0	acetamides
phenacetin Saridon: contains phenacetin, caffeine, propyphenazone & pyrithyldione	2.44	2	0	acetamides; aromatic ether	cyclooxygenase 3 inhibitor; non-narcotic analgesic; peripheral nervous system drug
phenazopyridine Phenazopyridine: A local anesthetic that has been used in urinary tract disorders. Its use is limited by problems with toxicity (primarily blood disorders) and potential carcinogenicity.. phenazopyridine : A diaminopyridine that is 2,6-diaminopyridine substituted at position 3 by a phenylazo group. A local anesthetic that has topical analgesic effect on mucosa lining of the urinary tract. Its use is limited by problems with toxicity (primarily blood disorders) and potential carcinogenicity.	2.04	1	0	diaminopyridine; monoazo compound	anticoronaviral agent; carcinogenic agent; local anaesthetic; non-narcotic analgesic
phenobarbital Phenobarbital: A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.. phenobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.	4.59	8	0	barbiturates	anticonvulsant; drug allergen; excitatory amino acid antagonist; sedative
phenolphthalein Phenolphthalein: An acid-base indicator which is colorless in acid solution, but turns pink to red as the solution becomes alkaline. It is used medicinally as a cathartic.	2	1	0	phenols
phenoxybenzamine Phenoxybenzamine: An alpha-adrenergic antagonist with long duration of action. It has been used to treat hypertension and as a peripheral vasodilator.	3.23	1	0	aromatic amine
phentermine Phentermine: A central nervous system stimulant and sympathomimetic with actions and uses similar to those of DEXTROAMPHETAMINE. It has been used most frequently in the treatment of obesity.	3.58	2	0	primary amine	adrenergic agent; appetite depressant; central nervous system drug; central nervous system stimulant; dopaminergic agent; sympathomimetic agent
4-phenylbutyric acid 4-phenylbutyric acid: RN refers to the parent cpd. 4-phenylbutyric acid : A monocarboxylic acid the structure of which is that of butyric acid substituted with a phenyl group at C-4. It is a histone deacetylase inhibitor that displays anticancer activity. It inhibits cell proliferation, invasion and migration and induces apoptosis in glioma cells. It also inhibits protein isoprenylation, depletes plasma glutamine, increases production of foetal haemoglobin through transcriptional activation of the gamma-globin gene and affects hPPARgamma activation.	3.23	1	0	monocarboxylic acid	antineoplastic agent; apoptosis inducer; EC 3.5.1.98 (histone deacetylase) inhibitor; prodrug
phenylbutazone Phenylbutazone: A butyl-diphenyl-pyrazolidinedione that has anti-inflammatory, antipyretic, and analgesic activities. It has been used in ANKYLOSING SPONDYLITIS; RHEUMATOID ARTHRITIS; and REACTIVE ARTHRITIS.. phenylbutazone : A member of the class of pyrazolidines that is 1,2-diphenylpyrazolidine-3,5-dione carrying a butyl group at the 4-position.	4.27	3	0	pyrazolidines	antirheumatic drug; EC 1.1.1.184 [carbonyl reductase (NADPH)] inhibitor; metabolite; non-narcotic analgesic; non-steroidal anti-inflammatory drug; peripheral nervous system drug
moxonidine moxonidine: structure given in first source	2.45	2	0	organohalogen compound; pyrimidines
pimobendan pimobendan: produces arterial & venous dilatation in dogs; structure given in first source	2.04	1	0	benzimidazoles; pyridazinone	cardiotonic drug; EC 3.1.4.* (phosphoric diester hydrolase) inhibitor; vasodilator agent
pindolol Pindolol: A moderately lipophilic beta blocker (ADRENERGIC BETA-ANTAGONISTS). It is non-cardioselective and has intrinsic sympathomimetic actions, but little membrane-stabilizing activity. (From Martindale, The Extra Pharmocopoeia, 30th ed, p638). pindolol : A member of the class of indols which is the 2-hydroxy-3-(isopropylamino)propyl ether derivative of 1H-indol-4-ol.	4.06	4	0	indoles; secondary amine	antiglaucoma drug; antihypertensive agent; beta-adrenergic antagonist; serotonergic antagonist; vasodilator agent
pioglitazone Pioglitazone: A thiazolidinedione and PPAR GAMMA agonist that is used in the treatment of TYPE 2 DIABETES MELLITUS.. pioglitazone : A member of the class of thiazolidenediones that is 1,3-thiazolidine-2,4-dione substituted by a benzyl group at position 5 which in turn is substituted by a 2-(5-ethylpyridin-2-yl)ethoxy group at position 4 of the phenyl ring. It exhibits hypoglycemic activity.	3.23	1	0	aromatic ether; pyridines; thiazolidinediones	antidepressant; cardioprotective agent; EC 2.7.1.33 (pantothenate kinase) inhibitor; EC 6.2.1.3 (long-chain-fatty-acid--CoA ligase) inhibitor; ferroptosis inhibitor; geroprotector; hypoglycemic agent; insulin-sensitizing drug; PPARgamma agonist; xenobiotic
pipemidic acid Pipemidic Acid: Antimicrobial against Gram negative and some Gram positive bacteria. It is protein bound and concentrated in bile and urine and used for gastrointestinal, biliary, and urinary infections.. pipemidic acid : A pyridopyrimidine that is 5-oxo-5,8-dihydropyrido[2,3-d]pyrimidine-6-carboxylic acid substituted at position 2 by a piperazin-1-yl group and at position 8 by an ethyl group. A synthetic broad-spectrum antibacterial, it is used for treatment of gastrointestinal, biliary, and urinary infections.	2.31	1	0	amino acid; monocarboxylic acid; N-arylpiperazine; pyridopyrimidine; quinolone antibiotic	antibacterial drug; DNA synthesis inhibitor
pipobroman Pipobroman: An antineoplastic agent that acts by alkylation.. pipobroman : An N-acylpiperazine that is piperazine in which each of the nitrogens has been acylated by a 3-bromopropionoyl group. An anti-cancer drug.	2.04	1	0	N-acylpiperazine; organobromine compound; tertiary carboxamide	alkylating agent; antineoplastic agent
pirenzepine Pirenzepine: An antimuscarinic agent that inhibits gastric secretion at lower doses than are required to affect gastrointestinal motility, salivary, central nervous system, cardiovascular, ocular, and urinary function. It promotes the healing of duodenal ulcers and due to its cytoprotective action is beneficial in the prevention of duodenal ulcer recurrence. It also potentiates the effect of other antiulcer agents such as CIMETIDINE and RANITIDINE. It is generally well tolerated by patients.	2	1	0	pyridobenzodiazepine	anti-ulcer drug; antispasmodic drug; muscarinic antagonist
piretanide piretanide: potent inhibitor of chloride transport; structure	2.45	2	0	aromatic ether
polythiazide [no description available]	3.58	2	0	benzothiadiazine
potassium chloride Potassium Chloride: A white crystal or crystalline powder used in BUFFERS; FERTILIZERS; and EXPLOSIVES. It can be used to replenish ELECTROLYTES and restore WATER-ELECTROLYTE BALANCE in treating HYPOKALEMIA.. potassium chloride : A metal chloride salt with a K(+) counterion.	2.63	3	0	inorganic chloride; inorganic potassium salt; potassium salt	fertilizer
practolol Practolol: A beta-1 adrenergic antagonist that has been used in the emergency treatment of CARDIAC ARRYTHMIAS.. practolol : N-(4-Hydroxyphenyl)acetamide in which the hydrogen of the phenolic hydroxy group is substituted by a 3-(isopropylaminoamino)-2-hydroxypropyl group. A selective beta blocker, it has been used in the emergency treatment of cardiac arrhythmias.	2.05	1	0	acetamides; ethanolamines; propanolamine; secondary alcohol; secondary amino compound	anti-arrhythmia drug; beta-adrenergic antagonist
duodote duodote: consists of atropine and pralidoxime chloride; for treating those exposed to organophosphorus-containing nerve agents	3.23	1	0	pyridinium ion	antidote to organophosphate poisoning; antidote to sarin poisoning; cholinergic drug; cholinesterase reactivator
praziquantel azinox: Russian drug	3.23	1	0	isoquinolines
prazosin Prazosin: A selective adrenergic alpha-1 antagonist used in the treatment of HEART FAILURE; HYPERTENSION; PHEOCHROMOCYTOMA; RAYNAUD DISEASE; PROSTATIC HYPERTROPHY; and URINARY RETENTION.. prazosin : A member of the class of piperazines that is piperazine substituted by a furan-2-ylcarbonyl group and a 4-amino-6,7-dimethoxyquinazolin-2-yl group at positions 1 and 4 respectively.	4.06	4	0	aromatic ether; furans; monocarboxylic acid amide; piperazines; quinazolines	alpha-adrenergic antagonist; antihypertensive agent; EC 3.4.21.26 (prolyl oligopeptidase) inhibitor
prilocaine Prilocaine: A local anesthetic that is similar pharmacologically to LIDOCAINE. Currently, it is used most often for infiltration anesthesia in dentistry.. prilocaine : An amino acid amide in which N-propyl-DL-alanine and 2-methylaniline have combined to form the amide bond; used as a local anaesthetic.	2.44	2	0	amino acid amide; monocarboxylic acid amide	anticonvulsant; local anaesthetic
primaquine Primaquine: An aminoquinoline that is given by mouth to produce a radical cure and prevent relapse of vivax and ovale malarias following treatment with a blood schizontocide. It has also been used to prevent transmission of falciparum malaria by those returning to areas where there is a potential for re-introduction of malaria. Adverse effects include anemias and GI disturbances. (From Martindale, The Extra Pharmacopeia, 30th ed, p404). primaquine : An N-substituted diamine that is pentane-1,4-diamine substituted by a 6-methoxyquinolin-8-yl group at the N(4) position. It is a drug used in the treatment of malaria and Pneumocystis pneumonia.	4.05	4	0	aminoquinoline; aromatic ether; N-substituted diamine	antimalarial
primidone Primidone: A barbiturate derivative that acts as a GABA modulator and anti-epileptic agent. It is partly metabolized to PHENOBARBITAL in the body and owes some of its actions to this metabolite.. primidone : A pyrimidone that is dihydropyrimidine-4,6(1H,5H)-dione substituted by an ethyl and a phenyl group at position 5. It is used as an anticonvulsant for treatment of various types of seizures.	3.83	3	0	pyrimidone	anticonvulsant; environmental contaminant; xenobiotic
probenecid Probenecid: The prototypical uricosuric agent. It inhibits the renal excretion of organic anions and reduces tubular reabsorption of urate. Probenecid has also been used to treat patients with renal impairment, and, because it reduces the renal tubular excretion of other drugs, has been used as an adjunct to antibacterial therapy.. probenecid : A sulfonamide in which the nitrogen of 4-sulfamoylbenzoic acid is substituted with two propyl groups.	10.14	15	0	benzoic acids; sulfonamide	uricosuric drug
probucol Probucol: A drug used to lower LDL and HDL cholesterol yet has little effect on serum-triglyceride or VLDL cholesterol. (From Martindale, The Extra Pharmacopoeia, 30th ed, p993).. probucol : A dithioketal that is propane-2,2-dithiol in which the hydrogens attached to both sulfur atoms are replaced by 3,5-di-tert-butyl-4-hydroxyphenyl groups. An anticholesteremic drug with antioxidant and anti-inflammatory properties, it is used to treat high levels of cholesterol in blood.	2.42	2	0	dithioketal; polyphenol	anti-inflammatory drug; anticholesteremic drug; antilipemic drug; antioxidant; cardiovascular drug
procainamide Procainamide: A class Ia antiarrhythmic drug that is structurally-related to PROCAINE.. procainamide : A benzamide that is 4-aminobenzamide substituted on the amide N by a 2-(diethylamino)ethyl group. It is a pharmaceutical antiarrhythmic agent used for the medical treatment of cardiac arrhythmias.	4.24	5	0	benzamides	anti-arrhythmia drug; platelet aggregation inhibitor; sodium channel blocker
procaine Procaine: A local anesthetic of the ester type that has a slow onset and a short duration of action. It is mainly used for infiltration anesthesia, peripheral nerve block, and spinal block. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1016).. procaine : A benzoate ester, formally the result of esterification of 4-aminobenzoic acid with 2-diethylaminoethanol but formed experimentally by reaction of ethyl 4-aminobenzoate with 2-diethylaminoethanol.	2.65	3	0	benzoate ester; substituted aniline; tertiary amino compound	central nervous system depressant; drug allergen; local anaesthetic; peripheral nervous system drug
procarbazine Procarbazine: An antineoplastic agent used primarily in combination with mechlorethamine, vincristine, and prednisone (the MOPP protocol) in the treatment of Hodgkin's disease.. procarbazine : A benzamide obtained by formal condensation of the carboxy group of 4-[(2-methylhydrazino)methyl]benzoic acid with the amino group of isopropylamine. An antineoplastic chemotherapy drug used for treatment of Hodgkin's lymphoma. Metabolism yields azo-procarbazine and hydrogen peroxide, which results in the breaking of DNA strands.	3.58	2	0	benzamides; hydrazines	antineoplastic agent
prochlorperazine Prochlorperazine: A phenothiazine antipsychotic used principally in the treatment of NAUSEA; VOMITING; and VERTIGO. It is more likely than CHLORPROMAZINE to cause EXTRAPYRAMIDAL DISORDERS. (From Martindale, The Extra Pharmacopoeia, 30th ed, p612). prochlorperazine : A member of the class of phenothiazines that is 10H-phenothiazine having a chloro substituent at the 2-position and a 3-(4-methylpiperazin-1-yl)propyl group at the N-10 position.	4.02	4	0	N-alkylpiperazine; N-methylpiperazine; organochlorine compound; phenothiazines	alpha-adrenergic antagonist; antiemetic; cholinergic antagonist; dopamine receptor D2 antagonist; dopaminergic antagonist; EC 3.4.21.26 (prolyl oligopeptidase) inhibitor; first generation antipsychotic
procyclidine Procyclidine: A muscarinic antagonist that crosses the blood-brain barrier and is used in the treatment of drug-induced extrapyramidal disorders and in parkinsonism.. procyclidine : A tertiary alcohol that consists of propan-1-ol substituted by a cyclohexyl and a phenyl group at position 1 and a pyrrolidin-1-yl group at position 3.	3.83	3	0	pyrrolidines; tertiary alcohol	antidyskinesia agent; antiparkinson drug; muscarinic antagonist
promazine Promazine: A phenothiazine with actions similar to CHLORPROMAZINE but with less antipsychotic activity. It is primarily used in short-term treatment of disturbed behavior and as an antiemetic.. promazine : A phenothiazine deriative in which the phenothiazine tricycle has a 3-(dimethylaminopropyl) group at the N-10 position.	2.04	1	0	phenothiazines; tertiary amine	antiemetic; dopaminergic antagonist; EC 3.4.21.26 (prolyl oligopeptidase) inhibitor; H1-receptor antagonist; muscarinic antagonist; phenothiazine antipsychotic drug; serotonergic antagonist
promethazine Promethazine: A phenothiazine derivative with histamine H1-blocking, antimuscarinic, and sedative properties. It is used as an antiallergic, in pruritus, for motion sickness and sedation, and also in animals.. promethazine : A tertiary amine that is a substituted phenothiazine in which the ring nitrogen at position 10 is attached to C-3 of an N,N-dimethylpropan-2-amine moiety.	4.06	4	0	phenothiazines; tertiary amine	anti-allergic agent; anticoronaviral agent; antiemetic; antipruritic drug; H1-receptor antagonist; local anaesthetic; sedative
propafenone Propafenone: An antiarrhythmia agent that is particularly effective in ventricular arrhythmias. It also has weak beta-blocking activity.. propafenone : An aromatic ketone that is 3-(propylamino)propane-1,2-diol in which the hydrogen of the primary hydroxy group is replaced by a 2-(3-phenylpropanoyl)phenyl group. It is a class 1C antiarrhythmic drug with local anesthetic effects, and is used as the hydrochloride salt in the management of supraventricular and ventricular arrhythmias.	3.83	3	0	aromatic ketone; secondary alcohol; secondary amino compound	anti-arrhythmia drug
propantheline Propantheline: A muscarinic antagonist used as an antispasmodic, in rhinitis, in urinary incontinence, and in the treatment of ulcers. At high doses it has nicotinic effects resulting in neuromuscular blocking.	3.23	1	0	xanthenes
propofol Propofol: An intravenous anesthetic agent which has the advantage of a very rapid onset after infusion or bolus injection plus a very short recovery period of a couple of minutes. (From Smith and Reynard, Textbook of Pharmacology, 1992, 1st ed, p206). Propofol has been used as ANTICONVULSANTS and ANTIEMETICS.. propofol : A phenol resulting from the formal substitution of the hydrogen at the 2 position of 1,3-diisopropylbenzene by a hydroxy group.	3.58	2	0	phenols	anticonvulsant; antiemetic; intravenous anaesthetic; radical scavenger; sedative
propranolol Propranolol: A widely used non-cardioselective beta-adrenergic antagonist. Propranolol has been used for MYOCARDIAL INFARCTION; ARRHYTHMIA; ANGINA PECTORIS; HYPERTENSION; HYPERTHYROIDISM; MIGRAINE; PHEOCHROMOCYTOMA; and ANXIETY but adverse effects instigate replacement by newer drugs.. propranolol : A propanolamine that is propan-2-ol substituted by a propan-2-ylamino group at position 1 and a naphthalen-1-yloxy group at position 3.	4.06	4	0	naphthalenes; propanolamine; secondary amine	anti-arrhythmia drug; antihypertensive agent; anxiolytic drug; beta-adrenergic antagonist; environmental contaminant; human blood serum metabolite; vasodilator agent; xenobiotic
propyl gallate Propyl Gallate: Antioxidant for foods, fats, oils, ethers, emulsions, waxes, and transformer oils.	2.44	2	0	trihydroxybenzoic acid
protriptyline Protriptyline: Tricyclic antidepressant similar in action and side effects to IMIPRAMINE. It may produce excitation.	3.54	2	0	carbotricyclic compound	antidepressant
pyridostigmine [no description available]	3.85	3	0	pyridinium ion
pyrimethamine Maloprim: contains above 2 cpds	3.58	2	0	aminopyrimidine; monochlorobenzenes	antimalarial; antiprotozoal drug; EC 1.5.1.3 (dihydrofolate reductase) inhibitor
sch 16134 quazepam: structure given in first source	3.23	1	0	benzodiazepine
quetiapine [no description available]	3.23	1	0	dibenzothiazepine; N-alkylpiperazine; N-arylpiperazine	adrenergic antagonist; dopaminergic antagonist; histamine antagonist; second generation antipsychotic; serotonergic antagonist
rabeprazole Rabeprazole: A 4-(3-methoxypropoxy)-3-methylpyridinyl derivative of timoprazole that is used in the therapy of STOMACH ULCERS and ZOLLINGER-ELLISON SYNDROME. The drug inhibits H(+)-K(+)-EXCHANGING ATPASE which is found in GASTRIC PARIETAL CELLS.	3.85	3	0	benzimidazoles; pyridines; sulfoxide	anti-ulcer drug; EC 3.6.3.10 (H(+)/K(+)-exchanging ATPase) inhibitor
raloxifene raloxifene : A member of the class of 1-benzothiophenes that is 1-benzothiophene in which the hydrogens at positions 2, 3, and 6 have been replaced by p-hydroxyphenyl, p-[2-(piperidin-1-yl)ethoxy]benzoyl, and hydroxy groups, respectively.	3.54	2	0	1-benzothiophenes; aromatic ketone; N-oxyethylpiperidine; phenols	bone density conservation agent; estrogen antagonist; estrogen receptor modulator
ranitidine [no description available]	2.94	4	0	aralkylamine
resorcinol resorcinol: RN given refers to parent cpd; structure in Merck Index, 9th ed, #7951. resorcinol : A benzenediol that is benzene dihydroxylated at positions 1 and 3.	2.44	2	0	benzenediol; phenolic donor; resorcinols	erythropoietin inhibitor; sensitiser
riluzole Riluzole: A glutamate antagonist (RECEPTORS, GLUTAMATE) used as an anticonvulsant (ANTICONVULSANTS) and to prolong the survival of patients with AMYOTROPHIC LATERAL SCLEROSIS.	3.54	2	0	benzothiazoles
rimantadine Rimantadine: An RNA synthesis inhibitor that is used as an antiviral agent in the prophylaxis and treatment of influenza.	3.23	1	0	alkylamine
risperidone Risperidone: A selective blocker of DOPAMINE D2 RECEPTORS and SEROTONIN 5-HT2 RECEPTORS that acts as an atypical antipsychotic agent. It has been shown to improve both positive and negative symptoms in the treatment of SCHIZOPHRENIA.. risperidone : A member of the class of pyridopyrimidines that is 2-methyl-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidin-4-one carrying an additional 2-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl group at position 2.	4.06	4	0	1,2-benzoxazoles; heteroarylpiperidine; organofluorine compound; pyridopyrimidine	alpha-adrenergic antagonist; dopaminergic antagonist; EC 3.4.21.26 (prolyl oligopeptidase) inhibitor; H1-receptor antagonist; psychotropic drug; second generation antipsychotic; serotonergic antagonist
rizatriptan rizatriptan: structure given in first source; RN given refers to benzoate	3.85	3	0	tryptamines	anti-inflammatory drug; serotonergic agonist; vasoconstrictor agent
ropinirole [no description available]	3.23	1	0	indolones; tertiary amine	antidyskinesia agent; antiparkinson drug; central nervous system drug; dopamine agonist
sanguinarine benzophenanthridine alkaloid : A specific group of isoquinoline alkaloids that occur only in higher plants and are constituents mainly of the Papaveraceae family.	7.99	4	0	alkaloid antibiotic; benzophenanthridine alkaloid; botanical anti-fungal agent
salicylsalicylic acid salicylsalicylic acid: structure. salsalate : A dimeric benzoate ester obtained by intermolecular condensation between the carboxy of one molecule of salicylic acid with the phenol group of a second. It is a prodrug for salycylic acid that is used for treatment of rheumatoid arthritis and osteoarthritis and also shows activity against type II diabetes.	3.23	1	0	benzoate ester; benzoic acids; phenols; salicylates	antineoplastic agent; antirheumatic drug; EC 3.5.2.6 (beta-lactamase) inhibitor; hypoglycemic agent; non-narcotic analgesic; non-steroidal anti-inflammatory drug; prodrug
secobarbital Secobarbital: A barbiturate that is used as a sedative. Secobarbital is reported to have no anti-anxiety activity.. secobarbital : A member of the class of barbiturates that is barbituric acid in which the hydrogens at position 5 are substituted by prop-2-en-1-yl and pentan-2-yl groups.	3.23	1	0	barbiturates	anaesthesia adjuvant; GABA modulator; sedative
semustine Semustine: 4-Methyl derivative of LOMUSTINE; (CCNU). An antineoplastic agent which functions as an alkylating agent.. semustine : An organochlorine compound that is urea in which the two hydrogens on one of the amino groups are replaced by nitroso and 2-chloroethyl groups and one hydrogen from the other amino group is replaced by a 4-methylcyclohexyl group.	2.04	1	0	N-nitrosoureas; organochlorine compound	alkylating agent; antineoplastic agent; carcinogenic agent
sibutramine sibutramine: serotonin and norepinephrine transporter inhibitor; Meridia is tradename for sibutramine hydrochloride	3.23	1	0	organochlorine compound; tertiary amino compound	anti-obesity agent; serotonin uptake inhibitor
sulfadiazine Sulfadiazine: One of the short-acting SULFONAMIDES used in combination with PYRIMETHAMINE to treat toxoplasmosis in patients with acquired immunodeficiency syndrome and in newborns with congenital infections.. sulfadiazine : A sulfonamide consisting of pyrimidine with a 4-aminobenzenesulfonamido group at the 2-position.. diazine : The parent structure of the diazines.	4.71	9	0	pyrimidines; substituted aniline; sulfonamide antibiotic; sulfonamide	antiinfective agent; antimicrobial agent; antiprotozoal drug; coccidiostat; drug allergen; EC 1.1.1.153 [sepiapterin reductase (L-erythro-7,8-dihydrobiopterin forming)] inhibitor; EC 2.5.1.15 (dihydropteroate synthase) inhibitor; environmental contaminant; xenobiotic
sodium fluoride [no description available]	1.99	1	0	fluoride salt	mutagen
risedronic acid Risedronic Acid: A pyridine and diphosphonic acid derivative that acts as a CALCIUM CHANNEL BLOCKER and inhibits BONE RESORPTION.	3.85	3	0	pyridines
sotalol Sotalol: An adrenergic beta-antagonist that is used in the treatment of life-threatening arrhythmias.. sotalol : A sulfonamide that is N-phenylmethanesulfonamide in which the phenyl group is substituted at position 4 by a 1-hydroxy-2-(isopropylamino)ethyl group. It has both beta-adrenoreceptor blocking (Vaughan Williams Class II) and cardiac action potential duration prolongation (Vaughan Williams Class III) antiarrhythmic properties. It is used (usually as the hydrochloride salt) for the management of ventricular and supraventricular arrhythmias.	3.85	3	0	ethanolamines; secondary alcohol; secondary amino compound; sulfonamide	anti-arrhythmia drug; beta-adrenergic antagonist; environmental contaminant; xenobiotic
imatinib [no description available]	3.85	3	0	aromatic amine; benzamides; N-methylpiperazine; pyridines; pyrimidines	antineoplastic agent; apoptosis inducer; tyrosine kinase inhibitor
streptonigrin [no description available]	2.04	1	0	pyridines; quinolone	antimicrobial agent; antineoplastic agent
vorinostat Vorinostat: A hydroxamic acid and anilide derivative that acts as a HISTONE DEACETYLASE inhibitor. It is used in the treatment of CUTANEOUS T-CELL LYMPHOMA and SEZARY SYNDROME.. vorinostat : A dicarboxylic acid diamide comprising suberic (octanedioic) acid coupled to aniline and hydroxylamine. A histone deacetylase inhibitor, it is marketed under the name Zolinza for the treatment of cutaneous T cell lymphoma (CTCL).	3.58	2	0	dicarboxylic acid diamide; hydroxamic acid	antineoplastic agent; apoptosis inducer; EC 3.5.1.98 (histone deacetylase) inhibitor
succinylcholine Succinylcholine: A quaternary skeletal muscle relaxant usually used in the form of its bromide, chloride, or iodide. It is a depolarizing relaxant, acting in about 30 seconds and with a duration of effect averaging three to five minutes. Succinylcholine is used in surgical, anesthetic, and other procedures in which a brief period of muscle relaxation is called for.. succinylcholine : A quaternary ammonium ion that is the bis-choline ester of succinic acid.	3.48	2	0	quaternary ammonium ion; succinate ester	drug allergen; muscle relaxant; neuromuscular agent
sulfacetamide Sulfacetamide: An anti-bacterial agent that is used topically to treat skin infections and orally for urinary tract infections.. sulfacetamide : A sulfonamide that is sulfanilamide acylated on the sulfonamide nitrogen.	2.89	4	0	N-sulfonylcarboxamide; substituted aniline	antibacterial drug; antiinfective agent; antimicrobial agent; EC 2.5.1.15 (dihydropteroate synthase) inhibitor
sulfadimethoxine Sulfadimethoxine: A sulfanilamide that is used as an anti-infective agent.. sulfadimethoxine : A sulfonamide consisting of pyrimidine having methoxy substituents at the 2- and 6-positions and a 4-aminobenzenesulfonamido group at the 4-position.	2.36	2	0	aromatic ether; pyrimidines; substituted aniline; sulfonamide antibiotic; sulfonamide	antiinfective agent; antimicrobial agent; drug allergen; environmental contaminant; xenobiotic
sulfaguanidine Sulfaguanidine: A sulfanilamide antimicrobial agent that is used to treat enteric infections.. sulfaguanidine : A sulfonamide incorporating a guanidine moiety used to block the synthesis of folic acid; mostly used in veterinary medicine	2.04	1	0	sulfonamide antibiotic	antiinfective agent
sulfamethazine Sulfamethazine: A sulfanilamide anti-infective agent. It has a spectrum of antimicrobial action similar to other sulfonamides.. sulfamethazine : A sulfonamide consisting of pyrimidine with methyl substituents at the 4- and 6-positions and a 4-aminobenzenesulfonamido group at the 2-position.	2.04	1	0	pyrimidines; sulfonamide antibiotic; sulfonamide	antibacterial drug; antiinfective agent; antimicrobial agent; carcinogenic agent; drug allergen; EC 2.5.1.15 (dihydropteroate synthase) inhibitor; environmental contaminant; ligand; xenobiotic
sulfamethizole Sulfamethizole: A sulfathiazole antibacterial agent.. sulfamethizole : A sulfonamide consisting of a 1,3,4-thiadiazole nucleus with a methyl substituent at C-5 and a 4-aminobenzenesulfonamido group at C-2.	3.23	1	0	sulfonamide antibiotic; sulfonamide; thiadiazoles	antiinfective agent; antimicrobial agent; drug allergen; EC 2.5.1.15 (dihydropteroate synthase) inhibitor
sulfamethoxazole Sulfamethoxazole: A bacteriostatic antibacterial agent that interferes with folic acid synthesis in susceptible bacteria. Its broad spectrum of activity has been limited by the development of resistance. (From Martindale, The Extra Pharmacopoeia, 30th ed, p208). sulfamethoxazole : An isoxazole (1,2-oxazole) compound having a methyl substituent at the 5-position and a 4-aminobenzenesulfonamido group at the 3-position.	9.32	20	0	isoxazoles; substituted aniline; sulfonamide antibiotic; sulfonamide	antibacterial agent; antiinfective agent; antimicrobial agent; drug allergen; EC 1.1.1.153 [sepiapterin reductase (L-erythro-7,8-dihydrobiopterin forming)] inhibitor; EC 2.5.1.15 (dihydropteroate synthase) inhibitor; environmental contaminant; epitope; P450 inhibitor; xenobiotic
sulfamethoxypyridazine Sulfamethoxypyridazine: A sulfanilamide antibacterial agent.. sulfamethoxypyridazine : A sulfonamide consisting of pyridazine having a methoxy substituent at the 6-position and a 4-aminobenzenesulfonamido group at the 3-position.	2.65	3	0	pyridazines; sulfonamide antibiotic; sulfonamide	antiinfective agent; drug allergen; EC 2.5.1.15 (dihydropteroate synthase) inhibitor
sulfanilamide [no description available]	2.37	2	0	substituted aniline; sulfonamide antibiotic; sulfonamide	antibacterial agent; drug allergen; EC 4.2.1.1 (carbonic anhydrase) inhibitor
sulfapyridine Sulfapyridine: Antibacterial, potentially toxic, used to treat certain skin diseases.. sulfapyridine : A sulfonamide consisting of pyridine with a 4-aminobenzenesulfonamido group at the 2-position.	2.04	1	0	pyridines; substituted aniline; sulfonamide antibiotic; sulfonamide	antiinfective agent; dermatologic drug; drug allergen; environmental contaminant; xenobiotic
sulfasalazine Sulfasalazine: A drug that is used in the management of inflammatory bowel diseases. Its activity is generally considered to lie in its metabolic breakdown product, 5-aminosalicylic acid (see MESALAMINE) released in the colon. (From Martindale, The Extra Pharmacopoeia, 30th ed, p907). sulfasalazine : An azobenzene consisting of diphenyldiazene having a carboxy substituent at the 4-position, a hydroxy substituent at the 3-position and a 2-pyridylaminosulphonyl substituent at the 4'-position.	3.8	3	0
sulfathiazole Sulfathiazole: A sulfathiazole compound that is used as a short-acting anti-infective agent. It is no longer commonly used systemically due to its toxicity, but may still be applied topically in combination with other drugs for the treatment of vaginal and skin infections, and is still used in veterinary medicine.. sulfathiazole : A 1,3-thiazole compound having a 4-aminobenzenesulfonamido group at the 2-position.	3.58	2	0	1,3-thiazoles; substituted aniline; sulfonamide antibiotic; sulfonamide	antiinfective agent; drug allergen; EC 2.5.1.15 (dihydropteroate synthase) inhibitor; environmental contaminant; xenobiotic
sulfinpyrazone Sulfinpyrazone: A uricosuric drug that is used to reduce the serum urate levels in gout therapy. It lacks anti-inflammatory, analgesic, and diuretic properties.	2.72	3	0	pyrazolidines; sulfoxide	uricosuric drug
sulfisoxazole Sulfisoxazole: A short-acting sulfonamide antibacterial with activity against a wide range of gram- negative and gram-positive organisms.. sulfisoxazole : A sulfonamide antibacterial with an oxazole substituent. It has antibiotic activity against a wide range of gram-negative and gram-positive organisms.	3.09	5	0	isoxazoles; sulfonamide antibiotic; sulfonamide	antibacterial drug; drug allergen
sulfoxone sulfoxone: RN given refers to parent cpd	2.04	1	0	sulfonamide
2-(octylamino)-1-[4-(propan-2-ylthio)phenyl]-1-propanol [no description available]	3.23	1	0	alkylbenzene
sulpiride Sulpiride: A dopamine D2-receptor antagonist. It has been used therapeutically as an antidepressant, antipsychotic, and as a digestive aid. (From Merck Index, 11th ed). sulpiride : A member of the class of benzamides obtained from formal condensation between the carboxy group of 2-methoxy-5-sulfamoylbenzoic acid and the primary amino group of (1-ethylpyrrolidin-2-yl)methylamine.	2.42	2	0	benzamides; N-alkylpyrrolidine; sulfonamide	antidepressant; antiemetic; antipsychotic agent; dopaminergic antagonist
sumatriptan Sumatriptan: A serotonin agonist that acts selectively at 5HT1 receptors. It is used in the treatment of MIGRAINE DISORDERS.. sumatriptan : A sulfonamide that consists of N,N-dimethyltryptamine bearing an additional (N-methylsulfamoyl)methyl substituent at position 5. Selective agonist for a vascular 5-HT1 receptor subtype (probably a member of the 5-HT1D family). Used (in the form of its succinate salt) for the acute treatment of migraine with or without aura in adults.	4.06	4	0	sulfonamide; tryptamines	serotonergic agonist; vasoconstrictor agent
suprofen Suprofen: An IBUPROFEN-type anti-inflammatory analgesic and antipyretic. It inhibits prostaglandin synthesis and has been proposed as an anti-arthritic.. suprofen : An aromatic ketone that is thiophene substituted at C-2 by a 4-(1-carboxyethyl)benzoyl group.	2.45	2	0	aromatic ketone; monocarboxylic acid; thiophenes	antirheumatic drug; drug allergen; EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor; non-narcotic analgesic; non-steroidal anti-inflammatory drug; peripheral nervous system drug
suramin Suramin: A polyanionic compound with an unknown mechanism of action. It is used parenterally in the treatment of African trypanosomiasis and it has been used clinically with diethylcarbamazine to kill the adult Onchocerca. (From AMA Drug Evaluations Annual, 1992, p1643) It has also been shown to have potent antineoplastic properties.. suramin : A member of the class of phenylureas that is urea in which each of the amino groups has been substituted by a 3-({2-methyl-5-[(4,6,8-trisulfo-1-naphthyl)carbamoyl]phenyl}carbamoyl)phenyl group. An activator of both the rabbit skeletal muscle RyR1 and sheep cardiac RyR2 isoform ryanodine receptor channels, it has been used for the treatment of human African trypanosomiasis for over 100 years.	2.45	2	0	naphthalenesulfonic acid; phenylureas; secondary carboxamide	angiogenesis inhibitor; antinematodal drug; antineoplastic agent; apoptosis inhibitor; EC 2.7.11.13 (protein kinase C) inhibitor; GABA antagonist; GABA-gated chloride channel antagonist; purinergic receptor P2 antagonist; ryanodine receptor agonist; trypanocidal drug
gatifloxacin Gatifloxacin: A fluoroquinolone antibacterial agent and DNA TOPOISOMERASE II inhibitor that is used as an ophthalmic solution for the treatment of BACTERIAL CONJUNCTIVITIS.. gatifloxacin : A monocarboxylic acid that is 4-oxo-1,4-dihydroquinoline-3-carboxylic acid which is substituted on the nitrogen by a cyclopropyl group and at positions 6, 7, and 8 by fluoro, 3-methylpiperazin-1-yl, and methoxy groups, respectively. Gatifloxacin is an antibiotic of the fourth-generation fluoroquinolone family, that like other members of that family, inhibits the bacterial topoisomerase type-II enzymes.	4.04	13	0	N-arylpiperazine; organofluorine compound; quinolinemonocarboxylic acid; quinolone antibiotic; quinolone	antiinfective agent; antimicrobial agent; EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor
tegafur [no description available]	2.04	1	0	organohalogen compound; pyrimidines
temazepam Temazepam: A benzodiazepine that acts as a GAMMA-AMINOBUTYRIC ACID modulator and anti-anxiety agent.	3.54	2	0	benzodiazepine
temozolomide [no description available]	3.58	2	0	imidazotetrazine; monocarboxylic acid amide; triazene derivative	alkylating agent; antineoplastic agent; prodrug
terazosin Terazosin: induces decreased blood pressure; used in the treatment of benign prostatic hyperplasia	4.06	4	0	furans; piperazines; primary amino compound; quinazolines	alpha-adrenergic antagonist; antihypertensive agent; antineoplastic agent
terbutaline Terbutaline: A selective beta-2 adrenergic agonist used as a bronchodilator and tocolytic.. terbutaline : A member of the class of phenylethanolamines that is catechol substituted at position 5 by a 2-(tert-butylamino)-1-hydroxyethyl group.	4.24	5	0	phenylethanolamines; resorcinols	anti-asthmatic drug; beta-adrenergic agonist; bronchodilator agent; EC 3.1.1.7 (acetylcholinesterase) inhibitor; hypoglycemic agent; sympathomimetic agent; tocolytic agent
tetracaine Tetracaine: A potent local anesthetic of the ester type used for surface and spinal anesthesia.. tetracaine : A benzoate ester in which 4-N-butylbenzoic acid and 2-(dimethylamino)ethanol have combined to form the ester bond; a local ester anaesthetic (ester caine) used for surface and spinal anaesthesia.	2.04	1	0	benzoate ester; tertiary amino compound	local anaesthetic
thalidomide Thalidomide: A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, but withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of immunological and inflammatory disorders. Thalidomide displays immunosuppressive and anti-angiogenic activity. It inhibits release of TUMOR NECROSIS FACTOR-ALPHA from monocytes, and modulates other cytokine action.. thalidomide : A racemate comprising equimolar amounts of R- and S-thalidomide.. 2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione : A dicarboximide that is isoindole-1,3(2H)-dione in which the hydrogen attached to the nitrogen is substituted by a 2,6-dioxopiperidin-3-yl group.	3.58	2	0	phthalimides; piperidones
thiabendazole Tresaderm: dermatologic soln containing dexamethasone, thiabendazole & neomycin sulfate	3.58	2	0	1,3-thiazoles; benzimidazole fungicide; benzimidazoles	antifungal agrochemical; antinematodal drug
2,2'-thiodiethanol 2,2'-thiodiethanol: product of yperite hydrolysis; a hydrolysis product opf mustard gas; strongly stimulates differentiation of chick embryo myogenic cells. thiodiglycol : A diol that is pentane-1,5-diol in which the methylene group at position 3 is replaced by a sulfur atom	2.04	1	0	aliphatic sulfide; diol	antineoplastic agent; antioxidant; metabolite; solvent
thioridazine Thioridazine: A phenothiazine antipsychotic used in the management of PHYCOSES, including SCHIZOPHRENIA.. thioridazine : A phenothiazine derivative having a methylsulfanyl subsitituent at the 2-position and a (1-methylpiperidin-2-yl)ethyl] group at the N-10 position.	4.41	6	0	phenothiazines; piperidines	alpha-adrenergic antagonist; dopaminergic antagonist; EC 1.8.1.12 (trypanothione-disulfide reductase) inhibitor; EC 3.4.21.26 (prolyl oligopeptidase) inhibitor; first generation antipsychotic; H1-receptor antagonist; serotonergic antagonist
thiotepa Thiotepa: A very toxic alkylating antineoplastic agent also used as an insect sterilant. It causes skin, gastrointestinal, CNS, and bone marrow damage. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), thiotepa may reasonably be anticipated to be a carcinogen (Merck Index, 11th ed).	4.07	4	0	aziridines
tiaprofenic acid tiaprofenic acid: RN given refers to parent cpd; structure. tiaprofenic acid : An aromatic ketone that is thiophene substituted at C-2 by benzoyl and at C-4 by a 1-carboxyethyl group.	2.01	1	0	aromatic ketone; monocarboxylic acid; thiophenes	drug allergen; non-steroidal anti-inflammatory drug
ticlopidine Ticlopidine: An effective inhibitor of platelet aggregation commonly used in the placement of STENTS in CORONARY ARTERIES.. ticlopidine : A thienopyridine that is 4,5,6,7-tetrahydrothieno[3,2-c]pyridine in which the hydrogen attached to the nitrogen is replaced by an o-chlorobenzyl group.	3.23	1	0	monochlorobenzenes; thienopyridine	anticoagulant; fibrin modulating drug; hematologic agent; P2Y12 receptor antagonist; platelet aggregation inhibitor
tinidazole Tinidazole: A nitroimidazole alkylating agent that is used as an antitrichomonal agent against TRICHOMONAS VAGINALIS; ENTAMOEBA HISTOLYTICA; and GIARDIA LAMBLIA infections. It also acts as an antibacterial agent for the treatment of BACTERIAL VAGINOSIS and anaerobic bacterial infections.. tinidazole : 1H-imidazole substituted at C-1 by a (2-ethylsulfonyl)ethyl group, at C-2 by a methyl group and at C-5 by a nitro group. It is used as an antiprotozoal, antibacterial agent.	3.85	3	0	imidazoles	antiamoebic agent; antibacterial drug; antiparasitic agent; antiprotozoal drug
tiopronin Tiopronin: Sulfhydryl acylated derivative of GLYCINE.	3.23	1	0	N-acyl-amino acid
tizanidine tizanidine: RN given refers to parent cpd; structure. tizanidine : 2,1,3-Benzothiadiazole substituted at C-4 by a Delta(1)-imidazolin-2-ylamino group and at C-4 by a chloro group. It is an agonist at alpha2-adrenergic receptor sites.	4.06	4	0	benzothiadiazole; imidazoles	alpha-adrenergic agonist; muscle relaxant
tolazamide Tolazamide: A sulphonylurea hypoglycemic agent with actions and uses similar to those of CHLORPROPAMIDE.. tolazamide : An N-sulfonylurea that is 1-tosylurea in which a hydrogen attached to the nitrogen at position 3 is replaced by an azepan-1-yl group. A hypoglycemic agent, it is used for the treatment of type 2 diabetes mellitus.	3.58	2	0	N-sulfonylurea	hypoglycemic agent; potassium channel blocker
tolbutamide Tolbutamide: A sulphonylurea hypoglycemic agent with actions and uses similar to those of CHLORPROPAMIDE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p290). tolbutamide : An N-sulfonylurea that consists of 1-butylurea having a tosyl group attached at the 3-position.	4.24	5	0	N-sulfonylurea	human metabolite; hypoglycemic agent; insulin secretagogue; potassium channel blocker
tolmetin Tolmetin: A non-steroidal anti-inflammatory agent (ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL) similar in mode of action to INDOMETHACIN.. tolmetin : A monocarboxylic acid that is (1-methylpyrrol-2-yl)acetic acid substituted at position 5 on the pyrrole ring by a 4-methylbenzoyl group. Used in the form of its sodium salt dihydrate as a nonselective nonsteroidal anti-inflammatory drug.	3.54	2	0	aromatic ketone; monocarboxylic acid; pyrroles	EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor; non-steroidal anti-inflammatory drug
ultram 2-[(dimethylamino)methyl]-1-(3-methoxyphenyl)cyclohexanol : A tertiary alcohol that is cyclohexanol substituted at positions 1 and 2 by 3-methoxyphenyl and dimethylaminomethyl groups respectively.	4.06	4	0	aromatic ether; tertiary alcohol; tertiary amino compound
tranexamic acid Tranexamic Acid: Antifibrinolytic hemostatic used in severe hemorrhage.	3.58	2	0	amino acid
trazodone Trazodone: A serotonin uptake inhibitor that is used as an antidepressive agent. It has been shown to be effective in patients with major depressive disorders and other subsets of depressive disorders. It is generally more useful in depressive disorders associated with insomnia and anxiety. This drug does not aggravate psychotic symptoms in patients with schizophrenia or schizoaffective disorders. (From AMA Drug Evaluations Annual, 1994, p309). trazodone : An N-arylpiperazine in which one nitrogen is substituted by a 3-chlorophenyl group, while the other is substituted by a 3-(3-oxo[1,2,4]triazolo[4,3-a]pyridin-2(3H)-yl)propyl group.	3.83	3	0	monochlorobenzenes; N-alkylpiperazine; N-arylpiperazine; triazolopyridine	adrenergic antagonist; antidepressant; anxiolytic drug; H1-receptor antagonist; sedative; serotonin uptake inhibitor
triamterene Triamterene: A pteridinetriamine compound that inhibits SODIUM reabsorption through SODIUM CHANNELS in renal EPITHELIAL CELLS.. triamterene : Pteridine substituted at positions 2, 4 and 7 with amino groups and at position 6 with a phenyl group. A sodium channel blocker, it is used as a diuretic in the treatment of hypertension and oedema.	4.24	5	0	pteridines	diuretic; sodium channel blocker
triazolam Triazolam: A short-acting benzodiazepine used in the treatment of insomnia. Some countries temporarily withdrew triazolam from the market because of concerns about adverse reactions, mostly psychological, associated with higher dose ranges. Its use at lower doses with appropriate care and labeling has been reaffirmed by the FDA and most other countries.	4.06	4	0	triazolobenzodiazepine	sedative
trichlormethiazide Trichlormethiazide: A thiazide diuretic with properties similar to those of HYDROCHLOROTHIAZIDE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p830). trichlormethiazide : A benzothiadiazine, hydrogenated at positions 2, 3 and 4 and substituted with an aminosulfonyl group at C-7, a chloro substituent at C-6 and a dichloromethyl group at C-3 and with S-1 as an S,S-dioxide. A sulfonamide antibiotic, it is used as a diuretic to treat oedema (including that associated with heart failure) and hypertension.	2.04	1	0	benzothiadiazine; sulfonamide antibiotic	antihypertensive agent; diuretic
2,2',2''-trichlorotriethylamine 2,2',2''-trichlorotriethylamine: RN given refers to parent cpd; structure	2.04	1	0
triclosan [no description available]	2.01	1	0	aromatic ether; dichlorobenzene; monochlorobenzenes; phenols	antibacterial agent; antimalarial; drug allergen; EC 1.3.1.9 [enoyl-[acyl-carrier-protein] reductase (NADH)] inhibitor; EC 1.5.1.3 (dihydrofolate reductase) inhibitor; fungicide; persistent organic pollutant; xenobiotic
trifluoperazine [no description available]	3.23	1	0	N-alkylpiperazine; N-methylpiperazine; organofluorine compound; phenothiazines	antiemetic; calmodulin antagonist; dopaminergic antagonist; EC 1.8.1.12 (trypanothione-disulfide reductase) inhibitor; EC 5.3.3.5 (cholestenol Delta-isomerase) inhibitor; phenothiazine antipsychotic drug
trihexyphenidyl Trihexyphenidyl: One of the centrally acting MUSCARINIC ANTAGONISTS used for treatment of PARKINSONIAN DISORDERS and drug-induced extrapyramidal movement disorders and as an antispasmodic.	3.23	1	0	amine
trimethadione Trimethadione: An anticonvulsant effective in absence seizures, but generally reserved for refractory cases because of its toxicity. (From AMA Drug Evaluations Annual, 1994, p378). trimethadione : An oxazolidinone that is 1,3-oxazolidine-2,4-dione substituted by methyl groups at positions 3, 5 and 5. It is an antiepileptic agent.	3.58	2	0	oxazolidinone	anticonvulsant; geroprotector
trimethobenzamide trimethobenzamide: major descriptor (64-84); on-line search BENZAMIDES (64-84); Index Medicus search TRIMETHOBENZAMIDE (64-84); RN given refers to parent cpd. trimethobenzamide : The amide obtained by formal condensation of 3,4,5-trihydroxybenzoic acid with 4-[2-(N,N-dimethylamino)ethoxy]benzylamine. It is used to prevent nausea and vomitting in humans.	3.23	1	0	benzamides; tertiary amino compound	antiemetic
trimethoprim Trimethoprim: A pyrimidine inhibitor of dihydrofolate reductase, it is an antibacterial related to PYRIMETHAMINE. It is potentiated by SULFONAMIDES and the TRIMETHOPRIM, SULFAMETHOXAZOLE DRUG COMBINATION is the form most often used. It is sometimes used alone as an antimalarial. TRIMETHOPRIM RESISTANCE has been reported.. trimethoprim : An aminopyrimidine antibiotic whose structure consists of pyrimidine 2,4-diamine and 1,2,3-trimethoxybenzene moieties linked by a methylene bridge.	10.93	33	0	aminopyrimidine; methoxybenzenes	antibacterial drug; diuretic; drug allergen; EC 1.5.1.3 (dihydrofolate reductase) inhibitor; environmental contaminant; xenobiotic
trimetrexate Trimetrexate: A nonclassical folic acid inhibitor through its inhibition of the enzyme dihydrofolate reductase. It is being tested for efficacy as an antineoplastic agent and as an antiparasitic agent against PNEUMOCYSTIS PNEUMONIA in AIDS patients. Myelosuppression is its dose-limiting toxic effect.	4.07	4	0
trimipramine Trimipramine: Tricyclic antidepressant similar to IMIPRAMINE, but with more antihistaminic and sedative properties.. trimipramine : A dibenzoazepine that is 10,11-dihydro-5H-dibenzo[b,f]azepine substituted by a 3-(dimethylamino)-2-methylpropyl group at the nitrogen atom. It is used as an antidepressant.	3.58	2	0	dibenzoazepine; tertiary amino compound	antidepressant; environmental contaminant; xenobiotic
troglitazone Troglitazone: A chroman and thiazolidinedione derivative that acts as a PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS (PPAR) agonist. It was formerly used in the treatment of TYPE 2 DIABETES MELLITUS, but has been withdrawn due to hepatotoxicity.	3.23	1	0	chromanes; thiazolidinone	anticoagulant; anticonvulsant; antineoplastic agent; antioxidant; EC 6.2.1.3 (long-chain-fatty-acid--CoA ligase) inhibitor; ferroptosis inhibitor; hypoglycemic agent; platelet aggregation inhibitor; vasodilator agent
tyramine [no description available]	3.23	1	0	monoamine molecular messenger; primary amino compound; tyramines	EC 3.1.1.8 (cholinesterase) inhibitor; Escherichia coli metabolite; human metabolite; mouse metabolite; neurotransmitter
delavirdine Delavirdine: A potent, non-nucleoside reverse transcriptase inhibitor with activity specific for HIV-1.. delavirdine : The amide resulting from the formal condensation of 5-[(methylsulfonyl)amino]-1H-indole-2-carboxylic acid and 4-amino group of 1-[3-(isopropylamino)pyridin-2-yl]piperazine, delavirdine is a non-nucleoside reverse transcriptase inhibitor with activity specific for HIV-1. Viral resistance emerges rapidly when delavirdine is used alone, so it is therefore used (as the methanesulfonic acid salt) with other antiretrovirals for combination therapy of HIV infection.	3.23	1	0	aminopyridine; indolecarboxamide; N-acylpiperazine; sulfonamide	antiviral drug; HIV-1 reverse transcriptase inhibitor
urapidil [no description available]	2.42	2	0	piperazines
urethane [no description available]	2.04	1	0	carbamate ester	fungal metabolite; mutagen
usnic acid [no description available]	2.07	1	0	benzofurans
venlafaxine venlafaxine : A tertiary amino compound that is N,N-dimethylethanamine substituted at position 1 by a 1-hydroxycyclohexyl and 4-methoxyphenyl group.	4.06	4	0	cyclohexanols; monomethoxybenzene; tertiary alcohol; tertiary amino compound	adrenergic uptake inhibitor; analgesic; antidepressant; dopamine uptake inhibitor; environmental contaminant; serotonin uptake inhibitor; xenobiotic
vesamicol vesamicol: RN given refers to parent cpd; structure	2.04	1	0	piperidines
vigabatrin [no description available]	3.23	1	0	gamma-amino acid	anticonvulsant; EC 2.6.1.19 (4-aminobutyrate--2-oxoglutarate transaminase) inhibitor
viloxazine Viloxazine: A morpholine derivative used as an antidepressant. It is similar in action to IMIPRAMINE.	2.04	1	0	aromatic ether
ici 204,219 zafirlukast: a leukotriene D4 receptor antagonist	3.23	1	0	carbamate ester; indoles; N-sulfonylcarboxamide	anti-asthmatic agent; leukotriene antagonist
zaleplon zaleplon: an azabicyclo(4.3.0)nonane; a nonbenzodiazepine; one of the so-called of Z drugs (zopiclone, eszopiclone, zolpidem, and zaleplon) for which there is some correlation with tumors; a hypnotic with less marked effect on psychomotor functions compared to lorazepam. zaleplon : A pyrazolo[1,5-a]pyrimidine having a nitrile group at position 3 and a 3-(N-ethylacetamido)phenyl substituent at the 7-position.	3.85	3	0	nitrile; pyrazolopyrimidine	anticonvulsant; anxiolytic drug; central nervous system depressant; sedative
zolpidem Zolpidem: An imidazopyridine derivative and short-acting GABA-A receptor agonist that is used for the treatment of INSOMNIA.. zolpidem : An imidazo[1,2-a]pyridine compound having a 4-tolyl group at the 2-position, an N,N-dimethylcarbamoylmethyl group at the 3-position and a methyl substituent at the 6-position.	3.85	3	0	imidazopyridine	central nervous system depressant; GABA agonist; sedative
zonisamide Zonisamide: A benzisoxazole and sulfonamide derivative that acts as a CALCIUM CHANNEL blocker. It is used primarily as an adjunctive antiepileptic agent for the treatment of PARTIAL SEIZURES, with or without secondary generalization.. zonisamide : A 1,2-benzoxazole compound having a sulfamoylmethyl substituent at the 3-position.	3.23	1	0	1,2-benzoxazoles; sulfonamide	anticonvulsant; antioxidant; central nervous system drug; protective agent; T-type calcium channel blocker
zopiclone zopiclone: S(+)-enantiomer of racemic zopiclone; azabicyclo(4.3.0)nonane; a nonbenzodiazepine; one of the so-called of Z drugs (zopiclone, eszopiclone, zolpidem, and zaleplon) for which there is some correlation with tumors; was term of zopiclone 2004-2007. zopiclone : A pyrrolo[3,4-b]pyrazine compound having a 4-methylpiperazine-1-carboxyl group at the 5-position, a 5-chloropyridin-2-yl group at the 6-position and an oxo-substituent at the 7-position.	2.45	2	0	monochloropyridine; pyrrolopyrazine	central nervous system depressant; sedative
cortisone acetate Cortisone Acetate: The acetate ester of cortisone that is used mainly for replacement therapy in adrenocortical insufficiency and in the treatment of many allergic and inflammatory disorders.	3.23	1	0	corticosteroid hormone
mitomycin Mitomycin: An antineoplastic antibiotic produced by Streptomyces caespitosus. It is one of the bi- or tri-functional ALKYLATING AGENTS causing cross-linking of DNA and inhibition of DNA synthesis.. mitomycin : A family of aziridine-containing natural products isolated from Streptomyces caespitosus or Streptomyces lavendulae.	3.23	1	0	mitomycin	alkylating agent; antineoplastic agent
oxyphenonium Oxyphenonium: A quaternary ammonium anticholinergic agent with peripheral side effects similar to those of ATROPINE. It is used as an adjunct in the treatment of gastric and duodenal ulcer, and to relieve visceral spasms. The drug has also been used in the form of eye drops for mydriatic effect.	1.94	1	0	acylcholine
prednisolone Prednisolone: A glucocorticoid with the general properties of the corticosteroids. It is the drug of choice for all conditions in which routine systemic corticosteroid therapy is indicated, except adrenal deficiency states.. prednisolone : A glucocorticoid that is prednisone in which the oxo group at position 11 has been reduced to the corresponding beta-hydroxy group. It is a drug metabolite of prednisone.	4.35	6	0	11beta-hydroxy steroid; 17alpha-hydroxy steroid; 20-oxo steroid; 21-hydroxy steroid; 3-oxo-Delta(1),Delta(4)-steroid; C21-steroid; glucocorticoid; primary alpha-hydroxy ketone; tertiary alpha-hydroxy ketone	adrenergic agent; anti-inflammatory drug; antineoplastic agent; drug metabolite; environmental contaminant; immunosuppressive agent; xenobiotic
reserpine Reserpine: An alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria. Reserpine inhibits the uptake of norepinephrine into storage vesicles resulting in depletion of catecholamines and serotonin from central and peripheral axon terminals. It has been used as an antihypertensive and an antipsychotic as well as a research tool, but its adverse effects limit its clinical use.. reserpine : An alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria.	3.84	3	0	alkaloid ester; methyl ester; yohimban alkaloid	adrenergic uptake inhibitor; antihypertensive agent; EC 3.4.21.26 (prolyl oligopeptidase) inhibitor; environmental contaminant; first generation antipsychotic; plant metabolite; xenobiotic
cephaloridine Cephaloridine: A cephalosporin antibiotic.. cefaloridine : A cephalosporin compound having pyridinium-1-ylmethyl and 2-thienylacetamido side-groups. A first-generation semisynthetic derivative of cephalosporin C.	9.13	72	1	beta-lactam antibiotic allergen; cephalosporin; semisynthetic derivative	antibacterial drug
phentolamine Phentolamine: A nonselective alpha-adrenergic antagonist. It is used in the treatment of hypertension and hypertensive emergencies, pheochromocytoma, vasospasm of RAYNAUD DISEASE and frostbite, clonidine withdrawal syndrome, impotence, and peripheral vascular disease.. phentolamine : A substituted aniline that is 3-aminophenol in which the hydrogens of the amino group are replaced by 4-methylphenyl and 4,5-dihydro-1H-imidazol-2-ylmethyl groups respectively. An alpha-adrenergic antagonist, it is used for the treatment of hypertension.	3.23	1	0	imidazoles; phenols; substituted aniline; tertiary amino compound	alpha-adrenergic antagonist; vasodilator agent
sorbitol D-glucitol : The D-enantiomer of glucitol (also known as D-sorbitol).	3.23	1	0	glucitol	cathartic; Escherichia coli metabolite; food humectant; human metabolite; laxative; metabolite; mouse metabolite; Saccharomyces cerevisiae metabolite; sweetening agent
thymidine [no description available]	2.48	2	0	pyrimidine 2'-deoxyribonucleoside	Escherichia coli metabolite; human metabolite; metabolite; mouse metabolite
floxuridine Floxuridine: An antineoplastic antimetabolite that is metabolized to fluorouracil when administered by rapid injection; when administered by slow, continuous, intra-arterial infusion, it is converted to floxuridine monophosphate. It has been used to treat hepatic metastases of gastrointestinal adenocarcinomas and for palliation in malignant neoplasms of the liver and gastrointestinal tract.. floxuridine : A pyrimidine 2'-deoxyribonucleoside compound having 5-fluorouracil as the nucleobase; used to treat hepatic metastases of gastrointestinal adenocarcinomas and for palliation in malignant neoplasms of the liver and gastrointestinal tract.	2.42	2	0	nucleoside analogue; organofluorine compound; pyrimidine 2'-deoxyribonucleoside	antimetabolite; antineoplastic agent; antiviral drug; radiosensitizing agent
triethylenemelamine Triethylenemelamine: Toxic alkylating agent used in industry; also as antineoplastic and research tool to produce chromosome aberrations and cancers.	2.04	1	0	1,3,5-triazines	alkylating agent; insect sterilant
thyroxine Thyroxine: The major hormone derived from the thyroid gland. Thyroxine is synthesized via the iodination of tyrosines (MONOIODOTYROSINE) and the coupling of iodotyrosines (DIIODOTYROSINE) in the THYROGLOBULIN. Thyroxine is released from thyroglobulin by proteolysis and secreted into the blood. Thyroxine is peripherally deiodinated to form TRIIODOTHYRONINE which exerts a broad spectrum of stimulatory effects on cell metabolism.. thyroxine : An iodothyronine compound having iodo substituents at the 3-, 3'-, 5- and 5'-positions.	3.79	3	0	2-halophenol; iodophenol; L-phenylalanine derivative; non-proteinogenic L-alpha-amino acid; thyroxine zwitterion; thyroxine	antithyroid drug; human metabolite; mouse metabolite; thyroid hormone
dextroamphetamine Dextroamphetamine: The d-form of AMPHETAMINE. It is a central nervous system stimulant and a sympathomimetic. It has also been used in the treatment of narcolepsy and of attention deficit disorders and hyperactivity in children. Dextroamphetamine has multiple mechanisms of action including blocking uptake of adrenergics and dopamine, stimulating release of monamines, and inhibiting monoamine oxidase. It is also a drug of abuse and a psychotomimetic.. (S)-amphetamine : A 1-phenylpropan-2-amine that has S configuration.	3.23	1	0	1-phenylpropan-2-amine	adrenergic agent; adrenergic uptake inhibitor; dopamine uptake inhibitor; dopaminergic agent; neurotoxin; sympathomimetic agent
spironolactone Spironolactone: A potassium sparing diuretic that acts by antagonism of aldosterone in the distal renal tubules. It is used mainly in the treatment of refractory edema in patients with congestive heart failure, nephrotic syndrome, or hepatic cirrhosis. Its effects on the endocrine system are utilized in the treatments of hirsutism and acne but they can lead to adverse effects. (From Martindale, The Extra Pharmacopoeia, 30th ed, p827). spironolactone : A steroid lactone that is 17alpha-pregn-4-ene-21,17-carbolactone substituted by an oxo group at position 3 and an alpha-acetylsulfanyl group at position 7.	3.78	3	0	3-oxo-Delta(4) steroid; oxaspiro compound; steroid lactone; thioester	aldosterone antagonist; antihypertensive agent; diuretic; environmental contaminant; xenobiotic
aldosterone [no description available]	1.94	1	0	11beta-hydroxy steroid; 18-oxo steroid; 20-oxo steroid; 21-hydroxy steroid; 3-oxo-Delta(4) steroid; C21-steroid hormone; mineralocorticoid; primary alpha-hydroxy ketone; steroid aldehyde	human metabolite; mouse metabolite
allobarbital allobarbital: was heading 1976-94 (see under BARBITURATES 1976-90); ALLOBARBITONE, DIALLYLBARBITAL, DIALLYLBARBITURIC ACID, & DIALLYLMAL were see ALLOBARBITAL 1976-94; use BARBITURATES to search ALLOBARBITAL 1976-94; a barbiturate derivative with effects of intermediate duration; at lower doses, it is used as a sedative; at higher doses, it displays hypnotic effects	2.04	1	0	barbiturates
penicillamine Penicillamine: 3-Mercapto-D-valine. The most characteristic degradation product of the penicillin antibiotics. It is used as an antirheumatic and as a chelating agent in Wilson's disease.. penicillamine : An alpha-amino acid having the structure of valine substituted at the beta position with a sulfanyl group.	3.99	4	0	non-proteinogenic alpha-amino acid; penicillamine	antirheumatic drug; chelator; copper chelator; drug allergen
cysteine [no description available]	3.23	1	0	cysteine zwitterion; cysteine; L-alpha-amino acid; proteinogenic amino acid; serine family amino acid	EC 4.3.1.3 (histidine ammonia-lyase) inhibitor; flour treatment agent; human metabolite
prednisone Prednisone: A synthetic anti-inflammatory glucocorticoid derived from CORTISONE. It is biologically inert and converted to PREDNISOLONE in the liver.. prednisone : A synthetic glucocorticoid drug that is particularly effective as an immunosuppressant, and affects virtually all of the immune system. Prednisone is a prodrug that is converted by the liver into prednisolone (a beta-hydroxy group instead of the oxo group at position 11), which is the active drug and also a steroid.	5.36	19	0	11-oxo steroid; 17alpha-hydroxy steroid; 20-oxo steroid; 21-hydroxy steroid; 3-oxo-Delta(1),Delta(4)-steroid; C21-steroid; glucocorticoid; primary alpha-hydroxy ketone; tertiary alpha-hydroxy ketone	adrenergic agent; anti-inflammatory drug; antineoplastic agent; immunosuppressive agent; prodrug
estrone Hydroxyestrones: Estrone derivatives substituted with one or more hydroxyl groups in any position. They are important metabolites of estrone and other estrogens.	3.23	1	0	17-oxo steroid; 3-hydroxy steroid; phenolic steroid; phenols	antineoplastic agent; bone density conservation agent; estrogen; human metabolite; mouse metabolite
paramethasone Paramethasone: A glucocorticoid with the general properties of corticosteroids. It has been used by mouth in the treatment of all conditions in which corticosteroid therapy is indicated except adrenal-deficiency states for which its lack of sodium-retaining properties makes it less suitable than HYDROCORTISONE with supplementary FLUDROCORTISONE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p737)	2.04	1	0	fluorinated steroid
oxandrolone Oxandrolone: A synthetic hormone with anabolic and androgenic properties.	3.23	1	0	17beta-hydroxy steroid; 3-oxo steroid; anabolic androgenic steroid; oxa-steroid	anabolic agent; androgen
azauridine Azauridine: A triazine nucleoside used as an antineoplastic antimetabolite. It interferes with pyrimidine biosynthesis thereby preventing formation of cellular nucleic acids. As the triacetate, it is also effective as an antipsoriatic.	2.04	1	0	N-glycosyl-1,2,4-triazine	antimetabolite; antineoplastic agent; drug metabolite
penicillin g Penicillin G: A penicillin derivative commonly used in the form of its sodium or potassium salts in the treatment of a variety of infections. It is effective against most gram-positive bacteria and against gram-negative cocci. It has also been used as an experimental convulsant because of its actions on GAMMA-AMINOBUTYRIC ACID mediated synaptic transmission.. benzylpenicillin : A penicillin in which the substituent at position 6 of the penam ring is a phenylacetamido group.	13.27	355	5	penicillin allergen; penicillin	antibacterial drug; drug allergen; epitope
idoxuridine [no description available]	2.04	1	0	organoiodine compound; pyrimidine 2'-deoxyribonucleoside	antiviral drug; DNA synthesis inhibitor
pilocarpine Pilocarpine: A slowly hydrolyzed muscarinic agonist with no nicotinic effects. Pilocarpine is used as a miotic and in the treatment of glaucoma.. (+)-pilocarpine : The (+)-enantiomer of pilocarpine.	3.23	1	0	pilocarpine	antiglaucoma drug
triiodothyronine Triiodothyronine: A T3 thyroid hormone normally synthesized and secreted by the thyroid gland in much smaller quantities than thyroxine (T4). Most T3 is derived from peripheral monodeiodination of T4 at the 5' position of the outer ring of the iodothyronine nucleus. The hormone finally delivered and used by the tissues is mainly T3.. 3,3',5-triiodo-L-thyronine : An iodothyronine compound having iodo substituents at the 3-, 3'- and 5-positions. Although some is produced in the thyroid, most of the 3,3',5-triiodo-L-thyronine in the body is generated by mono-deiodination of L-thyroxine in the peripheral tissues. Its metabolic activity is about 3 to 5 times that of L-thyroxine. The sodium salt is used in the treatment of hypothyroidism.	3.23	1	0	2-halophenol; amino acid zwitterion; iodophenol; iodothyronine	human metabolite; mouse metabolite; thyroid hormone
alanine Alanine: A non-essential amino acid that occurs in high levels in its free state in plasma. It is produced from pyruvate by transamination. It is involved in sugar and acid metabolism, increases IMMUNITY, and provides energy for muscle tissue, BRAIN, and the CENTRAL NERVOUS SYSTEM.. alanine : An alpha-amino acid that consists of propionic acid bearing an amino substituent at position 2.	2.41	2	0	alanine zwitterion; alanine; L-alpha-amino acid; proteinogenic amino acid; pyruvate family amino acid	EC 4.3.1.15 (diaminopropionate ammonia-lyase) inhibitor; fundamental metabolite
chloramphenicol Amphenicol: Chloramphenicol and its derivatives.	16.74	169	3	C-nitro compound; carboxamide; diol; organochlorine compound	antibacterial drug; antimicrobial agent; Escherichia coli metabolite; geroprotector; Mycoplasma genitalium metabolite; protein synthesis inhibitor
glutamine Glutamine: A non-essential amino acid present abundantly throughout the body and is involved in many metabolic processes. It is synthesized from GLUTAMIC ACID and AMMONIA. It is the principal carrier of NITROGEN in the body and is an important energy source for many cells.. L-glutamine : An optically active form of glutamine having L-configuration.. glutamine : An alpha-amino acid that consists of butyric acid bearing an amino substituent at position 2 and a carbamoyl substituent at position 4.	3.48	2	0	amino acid zwitterion; glutamine family amino acid; glutamine; L-alpha-amino acid; polar amino acid zwitterion; proteinogenic amino acid	EC 1.14.13.39 (nitric oxide synthase) inhibitor; Escherichia coli metabolite; human metabolite; metabolite; micronutrient; mouse metabolite; nutraceutical; Saccharomyces cerevisiae metabolite
lysine Lysine: An essential amino acid. It is often added to animal feed.. lysine : A diamino acid that is caproic (hexanoic) acid bearing two amino substituents at positions 2 and 6.. L-lysine : An L-alpha-amino acid; the L-isomer of lysine.	2.63	3	0	aspartate family amino acid; L-alpha-amino acid zwitterion; L-alpha-amino acid; lysine; organic molecular entity; proteinogenic amino acid	algal metabolite; anticonvulsant; Escherichia coli metabolite; human metabolite; micronutrient; mouse metabolite; nutraceutical; plant metabolite; Saccharomyces cerevisiae metabolite
vincristine [no description available]	3.85	3	0	acetate ester; formamides; methyl ester; organic heteropentacyclic compound; organic heterotetracyclic compound; tertiary alcohol; tertiary amino compound; vinca alkaloid	antineoplastic agent; drug; microtubule-destabilising agent; plant metabolite; tubulin modulator
physostigmine Physostigmine: A cholinesterase inhibitor that is rapidly absorbed through membranes. It can be applied topically to the conjunctiva. It also can cross the blood-brain barrier and is used when central nervous system effects are desired, as in the treatment of severe anticholinergic toxicity.	3.58	2	0	carbamate ester; indole alkaloid	antidote to curare poisoning; EC 3.1.1.8 (cholinesterase) inhibitor; miotic
ethinyl estradiol Ethinyl Estradiol: A semisynthetic alkylated ESTRADIOL with a 17-alpha-ethinyl substitution. It has high estrogenic potency when administered orally, and is often used as the estrogenic component in ORAL CONTRACEPTIVES.. 17alpha-ethynylestradiol : A 3-hydroxy steroid that is estradiol substituted by a ethynyl group at position 17. It is a xenoestrogen synthesized from estradiol and has been shown to exhibit high estrogenic potency on oral administration.	2.42	2	0	17-hydroxy steroid; 3-hydroxy steroid; terminal acetylenic compound	xenoestrogen
apomorphine Apomorphine: A derivative of morphine that is a dopamine D2 agonist. It is a powerful emetic and has been used for that effect in acute poisoning. It has also been used in the diagnosis and treatment of parkinsonism, but its adverse effects limit its use.	3.58	2	0	aporphine alkaloid	alpha-adrenergic drug; antidyskinesia agent; antiparkinson drug; dopamine agonist; emetic; serotonergic drug
aminopyrine Aminopyrine: A pyrazolone with analgesic, anti-inflammatory, and antipyretic properties but has risk of AGRANULOCYTOSIS. A breath test with 13C-labeled aminopyrine has been used as a non-invasive measure of CYTOCHROME P-450 metabolic activity in LIVER FUNCTION TESTS.. aminophenazone : A pyrazolone that is 1,2-dihydro-3H-pyrazol-3-one substituted by a dimethylamino group at position 4, methyl groups at positions 1 and 5 and a phenyl group at position 2. It exhibits analgesic, anti-inflammatory, and antipyretic properties.	1.96	1	0	pyrazolone; tertiary amino compound	antipyretic; environmental contaminant; non-narcotic analgesic; non-steroidal anti-inflammatory drug; xenobiotic
methyltestosterone Methyltestosterone: A synthetic hormone used for androgen replacement therapy and as an hormonal antineoplastic agent (ANTINEOPLASTIC AGENTS, HORMONAL).. methyltestosterone : A 17beta-hydroxy steroid that is testosterone bearing a methyl group at the 17alpha position.	3.23	1	0	17beta-hydroxy steroid; 3-oxo-Delta(4) steroid; enone	anabolic agent; androgen; antineoplastic agent
dromostanolone dromostanolone: synthetic anabolic androgenic steroid used to lower plasma cholesterol & as antineoplastic agent in advanced breast neoplasms; major descriptor (66-86); on-line search ANDROSTANOLS (80-86); ANDROSTANES (68-86); INDEX MEDICUS search DROMOSTANOLONE (66-86); RN given refers to (2alpha,5alpha,17beta)-isomer	2.04	1	0	17beta-hydroxy steroid; 3-oxo-5alpha-steroid; anabolic androgenic steroid	anabolic agent; antineoplastic agent
tetrabenazine 9,10-dimethoxy-3-isobutyl-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-one : A benzoquinolizine that is 1,2,3,4,4a,9,10,10a-octahydrophenanthrene in which the carbon at position 10a is replaced by a nitrogen and which is substituted by an isobutyl group at position 2, an oxo group at position 3, and methoxy groups at positions 6 and 7.	3.23	1	0	benzoquinolizine; cyclic ketone; tertiary amino compound
adenosine diphosphate Adenosine Diphosphate: Adenosine 5'-(trihydrogen diphosphate). An adenine nucleotide containing two phosphate groups esterified to the sugar moiety at the 5'-position.	2.37	2	0	adenosine 5'-phosphate; purine ribonucleoside 5'-diphosphate	fundamental metabolite; human metabolite
cephalothin Cephalothin: A cephalosporin antibiotic.. cefalotin : A semisynthetic, first-generation cephalosporin antibiotic with acetoxymethyl and (2-thienylacetyl)nitrilo moieties at positions 3 and 7, respectively, of the core structure. Administered parenterally during surgery and to treat a wide spectrum of blood infections.	12.21	156	2	azabicycloalkene; beta-lactam antibiotic allergen; carboxylic acid; cephalosporin; semisynthetic derivative; thiophenes	antibacterial drug; antimicrobial agent
uridine diphosphate Uridine Diphosphate: A uracil nucleotide containing a pyrophosphate group esterified to C5 of the sugar moiety.	2.02	1	0	pyrimidine ribonucleoside 5'-diphosphate; uridine 5'-phosphate	Escherichia coli metabolite; mouse metabolite
kanamycin a Kanamycin: Antibiotic complex produced by Streptomyces kanamyceticus from Japanese soil. Comprises 3 components: kanamycin A, the major component, and kanamycins B and C, the minor components.. kanamycin : Kanamycin is a naturally occurring antibiotic complex from Streptomyces kanamyceticus that consists of several components: kanamycin A, the major component (also usually designated as kanamycin), and kanamycins B, C, D and X the minor components.	9.44	98	1	kanamycins	bacterial metabolite
bromodeoxyuridine Bromodeoxyuridine: A nucleoside that substitutes for thymidine in DNA and thus acts as an antimetabolite. It causes breaks in chromosomes and has been proposed as an antiviral and antineoplastic agent. It has been given orphan drug status for use in the treatment of primary brain tumors.	2.04	1	0	pyrimidine 2'-deoxyribonucleoside	antimetabolite; antineoplastic agent
carbostyril Quinolones: A group of derivatives of naphthyridine carboxylic acid, quinoline carboxylic acid, or NALIDIXIC ACID.. quinolin-2(1H)-one : A quinolone that is 1,2-dihydroquinoline substituted by an oxo group at position 2.	3.51	8	0	monohydroxyquinoline; quinolone	bacterial xenobiotic metabolite
phenylephrine Phenylephrine: An alpha-1 adrenergic agonist used as a mydriatic, nasal decongestant, and cardiotonic agent.. phenylephrine : A member of the class of the class of phenylethanolamines that is (1R)-2-(methylamino)-1-phenylethan-1-ol carrying an additional hydroxy substituent at position 3 on the phenyl ring.	2.37	2	0	phenols; phenylethanolamines; secondary amino compound	alpha-adrenergic agonist; cardiotonic drug; mydriatic agent; nasal decongestant; protective agent; sympathomimetic agent; vasoconstrictor agent
thiamine [no description available]	2.04	1	0	organic chloride salt; vitamin B1
levodopa Levodopa: The naturally occurring form of DIHYDROXYPHENYLALANINE and the immediate precursor of DOPAMINE. Unlike dopamine itself, it can be taken orally and crosses the blood-brain barrier. It is rapidly taken up by dopaminergic neurons and converted to DOPAMINE. It is used for the treatment of PARKINSONIAN DISORDERS and is usually given with agents that inhibit its conversion to dopamine outside of the central nervous system.. L-dopa : An optically active form of dopa having L-configuration. Used to treat the stiffness, tremors, spasms, and poor muscle control of Parkinson's disease	2.73	3	0	amino acid zwitterion; dopa; L-tyrosine derivative; non-proteinogenic L-alpha-amino acid	allelochemical; antidyskinesia agent; antiparkinson drug; dopaminergic agent; hapten; human metabolite; mouse metabolite; neurotoxin; plant growth retardant; plant metabolite; prodrug
edetic acid Edetic Acid: A chelating agent that sequesters a variety of polyvalent cations such as CALCIUM. It is used in pharmaceutical manufacturing and as a food additive.	4.16	5	0	ethylenediamine derivative; polyamino carboxylic acid; tetracarboxylic acid	anticoagulant; antidote; chelator; copper chelator; geroprotector
cysteamine Cysteamine: A mercaptoethylamine compound that is endogenously derived from the COENZYME A degradative pathway. The fact that cysteamine is readily transported into LYSOSOMES where it reacts with CYSTINE to form cysteine-cysteamine disulfide and CYSTEINE has led to its use in CYSTINE DEPLETING AGENTS for the treatment of CYSTINOSIS.. cysteamine : An amine that consists of an ethane skeleton substituted with a thiol group at C-1 and an amino group at C-2.	3.23	1	0	amine; thiol	geroprotector; human metabolite; mouse metabolite; radiation protective agent
acetylcholine chloride acetylcholine chloride : The chloride salt of acetylcholine, and a parasympatomimetic drug.	3.23	1	0	quaternary ammonium salt
mepazine mepazine: major descriptor (66-85); on-line search PHENOTHIAZINES (66-85); Index Medicus search MEPAZINE (66-85); RN given refers to parent cpd. pacatal : A phenothiazine derivative in which 10H-phenothiazine has an N-methylpiperidin-4-ylmethyl substituent at the N-10 position.	3.23	1	0	phenothiazines
methicillin Methicillin: One of the PENICILLINS which is resistant to PENICILLINASE but susceptible to a penicillin-binding protein. It is inactivated by gastric acid so administered by injection.. methicillin : A penicillin that is 6-aminopenicillanic acid in which one of the amino hydrogens is replaced by a 2,6-dimethoxybenzoyl group.	14.97	440	3	penicillin allergen; penicillin	antibacterial drug
niridazole Niridazole: An antischistosomal agent that has become obsolete.	2.04	1	0	1,3-thiazoles; C-nitro compound
cloxacillin Cloxacillin: A semi-synthetic antibiotic that is a chlorinated derivative of OXACILLIN.. cloxacillin : A semisynthetic penicillin antibiotic carrying a 3-(2-chlorophenyl)-5-methylisoxazole-4-carboxamido group at position 6.	11.35	182	1	penicillin allergen; penicillin; semisynthetic derivative	antibacterial agent; antibacterial drug
methylene blue Methylene Blue: A compound consisting of dark green crystals or crystalline powder, having a bronze-like luster. Solutions in water or alcohol have a deep blue color. Methylene blue is used as a bacteriologic stain and as an indicator. It inhibits GUANYLATE CYCLASE, and has been used to treat cyanide poisoning and to lower levels of METHEMOGLOBIN.. methylene blue : An organic chloride salt having 3,7-bis(dimethylamino)phenothiazin-5-ium as the counterion. A commonly used dye that also exhibits antioxidant, antimalarial, antidepressant and cardioprotective properties.	2.38	2	0	organic chloride salt	acid-base indicator; antidepressant; antimalarial; antimicrobial agent; antioxidant; cardioprotective agent; EC 1.4.3.4 (monoamine oxidase) inhibitor; EC 3.1.1.8 (cholinesterase) inhibitor; EC 4.6.1.2 (guanylate cyclase) inhibitor; fluorochrome; histological dye; neuroprotective agent; physical tracer
zoxazolamine Zoxazolamine: A uricosuric and muscle relaxant. Zoxazolamine acts centrally as a muscle relaxant, but the mechanism of its action is not understood.	2.04	1	0	benzoxazole
aniline [no description available]	2.04	1	0	anilines; primary arylamine
calcium acetate calcium acetate: a principal compound used as phosphate binders in patients with chronic renal failure; used like sevelamer. calcium acetate : The calcium salt of acetic acid. It is used, commonly as a hydrate, to treat hyperphosphataemia (excess phosphate in the blood) in patients with kidney disease: the calcium ion combines with dietary phosphate to form (insoluble) calcium phosphate, which is excreted in the faeces.	3.23	1	0	calcium salt	chelator
methionine Methionine: A sulfur-containing essential L-amino acid that is important in many body functions.. methionine : A sulfur-containing amino acid that is butyric acid bearing an amino substituent at position 2 and a methylthio substituent at position 4.	3.23	1	0	aspartate family amino acid; L-alpha-amino acid; methionine zwitterion; methionine; proteinogenic amino acid	antidote to paracetamol poisoning; human metabolite; micronutrient; mouse metabolite; nutraceutical
phenylalanine Phenylalanine: An essential aromatic amino acid that is a precursor of MELANIN; DOPAMINE; noradrenalin (NOREPINEPHRINE), and THYROXINE.. L-phenylalanine : The L-enantiomer of phenylalanine.. phenylalanine : An aromatic amino acid that is alanine in which one of the methyl hydrogens is substituted by a phenyl group.	1.94	1	0	amino acid zwitterion; erythrose 4-phosphate/phosphoenolpyruvate family amino acid; L-alpha-amino acid; phenylalanine; proteinogenic amino acid	algal metabolite; EC 3.1.3.1 (alkaline phosphatase) inhibitor; Escherichia coli metabolite; human xenobiotic metabolite; micronutrient; mouse metabolite; nutraceutical; plant metabolite; Saccharomyces cerevisiae metabolite
desoxycorticosterone Desoxycorticosterone: A steroid metabolite that is the 11-deoxy derivative of CORTICOSTERONE and the 21-hydroxy derivative of PROGESTERONE	2.07	1	0	20-oxo steroid; 21-hydroxy steroid; 3-oxo-Delta(4) steroid; mineralocorticoid; primary alpha-hydroxy ketone	human metabolite; mouse metabolite
colchicine (S)-colchicine : A colchicine that has (S)-configuration. It is a secondary metabolite, has anti-inflammatory properties and is used to treat gout, crystal-induced joint inflammation, familial Mediterranean fever, and many other conditions.	4.53	4	0	alkaloid; colchicine	anti-inflammatory agent; gout suppressant; mutagen
mebanazine mebanazine: RN given refers to parent cpd without isomeric designation; structure	3.23	1	0	benzenes
uracil mustard Uracil Mustard: Nitrogen mustard derivative of URACIL. It is a alkylating antineoplastic agent that is used in lymphatic malignancies, and causes mainly gastrointestinal and bone marrow damage.	2.04	1	0	aminouracil; nitrogen mustard
cycloheximide Cycloheximide: Antibiotic substance isolated from streptomycin-producing strains of Streptomyces griseus. It acts by inhibiting elongation during protein synthesis.. cycloheximide : A dicarboximide that is 4-(2-hydroxyethyl)piperidine-2,6-dione in which one of the hydrogens attached to the carbon bearing the hydroxy group is replaced by a 3,5-dimethyl-2-oxocyclohexyl group. It is an antibiotic produced by the bacterium Streptomyces griseus.	2.04	1	0	antibiotic fungicide; cyclic ketone; dicarboximide; piperidine antibiotic; piperidones; secondary alcohol	anticoronaviral agent; bacterial metabolite; ferroptosis inhibitor; neuroprotective agent; protein synthesis inhibitor
fluocinolone acetonide Fluocinolone Acetonide: A glucocorticoid derivative used topically in the treatment of various skin disorders. It is usually employed as a cream, gel, lotion, or ointment. It has also been used topically in the treatment of inflammatory eye, ear, and nose disorders. (From Martindale, The Extra Pharmacopoeia, 30th ed, p732). fluocinolone acetonide : A fluorinated steroid that is flunisolide in which the hydrogen at position 9 is replaced by fluorine. A corticosteroid with glucocorticoid activity, it is used (both as the anhydrous form and as the dihydrate) in creams, gels and ointments for the treatment of various skin disorders.	2.04	1	0	11beta-hydroxy steroid; 20-oxo steroid; 21-hydroxy steroid; 3-oxo-Delta(1),Delta(4)-steroid; cyclic ketal; fluorinated steroid; glucocorticoid; organic heteropentacyclic compound; primary alpha-hydroxy ketone	anti-inflammatory drug; antipruritic drug
sodium citrate, anhydrous Sodium Citrate: Sodium salts of citric acid that are used as buffers and food preservatives. They are used medically as anticoagulants in stored blood, and for urine alkalization in the prevention of KIDNEY STONES.. sodium citrate : The trisodium salt of citric acid.	1.99	1	0	organic sodium salt	anticoagulant; flavouring agent
norethindrone Norethindrone: A synthetic progestational hormone with actions similar to those of PROGESTERONE but functioning as a more potent inhibitor of ovulation. It has weak estrogenic and androgenic properties. The hormone has been used in treating amenorrhea, functional uterine bleeding, endometriosis, and for CONTRACEPTION.. norethisterone : A 17beta-hydroxy steroid that is testosterone in which the hydrogen at position 17 is replaced by an ethynyl group and in which the methyl group attached to position 10 is replaced by hydrogen.	2.38	2	0	17beta-hydroxy steroid; 3-oxo-Delta(4) steroid; terminal acetylenic compound; tertiary alcohol	progestin; synthetic oral contraceptive
cycloserine Cycloserine: Antibiotic substance produced by Streptomyces garyphalus.. D-cycloserine : A 4-amino-1,2-oxazolidin-3-one that has R configuration. It is an antibiotic produced by Streptomyces garyphalus or S. orchidaceus and is used as part of a multi-drug regimen for the treatment of tuberculosis when resistance to, or toxicity from, primary drugs has developed. An analogue of D-alanine, it interferes with bacterial cell wall synthesis in the cytoplasm by competitive inhibition of L-alanine racemase (which forms D-alanine from L-alanine) and D-alanine--D-alanine ligase (which incorporates D-alanine into the pentapeptide required for peptidoglycan formation and bacterial cell wall synthesis).	5.54	13	0	4-amino-1,2-oxazolidin-3-one; organonitrogen heterocyclic antibiotic; organooxygen heterocyclic antibiotic; zwitterion	antiinfective agent; antimetabolite; antitubercular agent; metabolite; NMDA receptor agonist
triaziquone Triaziquone: Alkylating antineoplastic agent used mainly for ovarian tumors. It is toxic to skin, gastrointestinal tract, bone marrow and kidneys.. triaziquone : A member of the class of 1,4-benzoquinones that is 1,4-benzoquinone in which three of the ring hydrogens are replaced by aziridin-1-yl groups.	2.04	1	0	1,4-benzoquinones; aziridines	alkylating agent; antineoplastic agent
benziodarone benziodarone: minor descriptor (75-89); on-line & INDEX MEDICUS search BENZOFURANS (68-89) & IODOBENZOATES (74)	3.23	1	0	aromatic ketone
ampicillin Ampicillin: Semi-synthetic derivative of penicillin that functions as an orally active broad-spectrum antibiotic.. ampicillin : A penicillin in which the substituent at position 6 of the penam ring is a 2-amino-2-phenylacetamido group.	13.98	476	6	beta-lactam antibiotic; penicillin allergen; penicillin	antibacterial drug
mannitol [no description available]	4.96	12	0	mannitol	allergen; antiglaucoma drug; compatible osmolytes; Escherichia coli metabolite; food anticaking agent; food bulking agent; food humectant; food stabiliser; food thickening agent; hapten; metabolite; osmotic diuretic; sweetening agent
cytarabine [no description available]	3.85	3	0	beta-D-arabinoside; monosaccharide derivative; pyrimidine nucleoside	antimetabolite; antineoplastic agent; antiviral agent; immunosuppressive agent
trifluridine Trifluridine: An antiviral derivative of THYMIDINE used mainly in the treatment of primary keratoconjunctivitis and recurrent epithelial keratitis due to HERPES SIMPLEX virus. (From Martindale, The Extra Pharmacopoeia, 30th ed, p557). trifluridine : A pyrimidine 2'-deoxyribonucleoside compound having 5-trifluoromethyluracil as the nucleobase. An antiviral drug used mainly in the treatment of primary keratoconjunctivitis and recurrent epithelial keratitis.	2.04	1	0	nucleoside analogue; organofluorine compound; pyrimidine 2'-deoxyribonucleoside	antimetabolite; antineoplastic agent; antiviral drug; EC 2.1.1.45 (thymidylate synthase) inhibitor
sulfobromophthalein sodium bromosulfophthalein sodium : An organic sodium salt that is the disodium salt of bromosulfophthalein.. bromosulfophthalein : An organosulfonic acid that consists of phthalide bearing four bromo substituents at positions 4, 5, 6 and 7 as well as two 4-hydroxy-3-sulfophenyl groups both located at position 1.	2.04	1	0	organic sodium salt	dye
mestranol [no description available]	1.94	1	0	17beta-hydroxy steroid; aromatic ether; terminal acetylenic compound	prodrug; xenoestrogen
methandrostenolone Methandrostenolone: A synthetic steroid with anabolic properties that are more pronounced than its androgenic effects. It has little progestational activity. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1188)	1.94	1	0	organic molecular entity
arginine Arginine: An essential amino acid that is physiologically active in the L-form.. arginine : An alpha-amino acid that is glycine in which the alpha-is substituted by a 3-guanidinopropyl group.	3.23	1	0	arginine; glutamine family amino acid; L-alpha-amino acid; proteinogenic amino acid	biomarker; Escherichia coli metabolite; micronutrient; mouse metabolite; nutraceutical
bromoethane bromoethane : A bromoalkane that is ethane carrying a bromo substituent. It is an alkylating agent used as a chemical intermediate in various organic syntheses.	2.05	1	0	bromoalkane; bromohydrocarbon; volatile organic compound	alkylating agent; carcinogenic agent; local anaesthetic; refrigerant; solvent
acetonitrile acetonitrile: RN given refers to unlabeled cpd. acetonitrile : A nitrile that is hydrogen cyanide in which the hydrogen has been replaced by a methyl group.	2.07	1	0	aliphatic nitrile; volatile organic compound	EC 3.5.1.4 (amidase) inhibitor; NMR chemical shift reference compound; polar aprotic solvent
tetramethylammonium tetramethylammonium: RN given refers to parent cpd. tetramethylammonium : The simplest quaternary ammonium cation, comprising a central nitrogen linked to four methyl groups.	1.99	1	0	quaternary ammonium ion
dalapon dalapon: RN given refers to parent cpd; structure	2.04	1	0	carboxylic acid; organohalogen compound
perflutren Definity: a fluorocarbon-filled ultrasonic contrast agent; Definity is tradename. octafluoropropane : A fluorocarbon that is propane in which all of the hydrogens have been replaced by fluorines.	3.23	1	0	fluoroalkane; fluorocarbon
triamcinolone acetonide Triamcinolone Acetonide: An esterified form of TRIAMCINOLONE. It is an anti-inflammatory glucocorticoid used topically in the treatment of various skin disorders. Intralesional, intramuscular, and intra-articular injections are also administered under certain conditions.. triamcinolone acetonide : A synthetic glucocorticoid that is the 16,17-acetonide of triamcinolone. Used to treat various skin infections.	2.04	1	0	11beta-hydroxy steroid; 20-oxo steroid; 21-hydroxy steroid; 3-oxo-Delta(4) steroid; cyclic ketal; fluorinated steroid; glucocorticoid; primary alpha-hydroxy ketone	anti-allergic agent; anti-inflammatory drug
fluoxymesterone Fluoxymesterone: An anabolic steroid that has been used in the treatment of male HYPOGONADISM, delayed puberty in males, and in the treatment of breast neoplasms in women.	3.23	1	0	11beta-hydroxy steroid; 17beta-hydroxy steroid; 3-oxo-Delta(4) steroid; anabolic androgenic steroid; fluorinated steroid	anabolic agent; antineoplastic agent
phencyclidine Phencyclidine: A hallucinogen formerly used as a veterinary anesthetic, and briefly as a general anesthetic for humans. Phencyclidine is similar to KETAMINE in structure and in many of its effects. Like ketamine, it can produce a dissociative state. It exerts its pharmacological action through inhibition of NMDA receptors (RECEPTORS, N-METHYL-D-ASPARTATE). As a drug of abuse, it is known as PCP and Angel Dust.. phencyclidine : A member of the class of piperidines that is piperidine in which the nitrogen is substituted with a 1-phenylcyclohexyl group. Formerly used as an anaesthetic agent, it exhibits both hallucinogenic and neurotoxic effects.	2.45	2	0	benzenes; piperidines	anaesthetic; neurotoxin; NMDA receptor antagonist; psychotropic drug
methsuximide methsuximide: anticonvulsant effective in petit mal & psychomotor epilepsy; has a number of unpleasant & toxic side effects; minor descriptor (75-86); on-line & INDEX MEDICUS search SUCCINIMIDES (75-86); RN given refers to parent cpd without isomeric designation	3.23	1	0	organic molecular entity
methylpentynol methylpentynol: structure	2.04	1	0	ynone
tromethamine Tromethamine: An organic amine proton acceptor. It is used in the synthesis of surface-active agents and pharmaceuticals; as an emulsifying agent for cosmetic creams and lotions, mineral oil and paraffin wax emulsions, as a biological buffer, and used as an alkalizer. (From Merck, 11th ed; Martindale, The Extra Pharmacopoeia, 30th ed, p1424)	3.48	2	0	primary amino compound; triol	buffer
quinic acid (-)-quinic acid : The (-)-enantiomer of quinic acid.	2.03	1	0
linalool linalool: RN given refers to parent cpd without isomeric designation; structure. linalool : A monoterpenoid that is octa-1,6-diene substituted by methyl groups at positions 3 and 7 and a hydroxy group at position 3. It has been isolated from plants like Ocimum canum.	2.21	1	0	monoterpenoid; tertiary alcohol	antimicrobial agent; fragrance; plant metabolite; volatile oil component
dichloroacetic acid [no description available]	2.04	1	0	monocarboxylic acid; organochlorine compound	astringent; marine metabolite
pantothenic acid Pantothenic Acid: A butyryl-beta-alanine that can also be viewed as pantoic acid complexed with BETA ALANINE. It is incorporated into COENZYME A and protects cells against peroxidative damage by increasing the level of GLUTATHIONE.. pantothenic acid : A member of the class of pantothenic acids that is an amide formed from pantoic acid and beta-alanine.. vitamin B5 : Any member of a group of vitamers that belong to the chemical structural class called pantothenic acids that exhibit biological activity against vitamin B5 deficiency. Deficiency of vitamin B5 is rare due to its widespread distribution in whole grain cereals, legumes and meat. Symptoms associated with vitamin B5 deficiency are difficult to asses since they are subtle and resemble those of other B vitamin deficiencies. The vitamers include (R)-pantothenic acid and its ionized and salt forms.. (R)-pantothenate : A pantothenate that is the conjugate base of (R)-pantothenic acid, obtained by deprotonation of the carboxy group.. (R)-pantothenic acid : A pantothenic acid having R-configuration.	2.1	1	0	pantothenic acid; vitamin B5	antidote to curare poisoning; geroprotector; human blood serum metabolite
methylprednisolone Methylprednisolone: A PREDNISOLONE derivative with similar anti-inflammatory action.. 6alpha-methylprednisolone : The 6alpha-stereoisomer of 6-methylprednisolone.	4.87	11	0	6-methylprednisolone; primary alpha-hydroxy ketone; tertiary alpha-hydroxy ketone	adrenergic agent; anti-inflammatory drug; antiemetic; environmental contaminant; neuroprotective agent; xenobiotic
brompheniramine Brompheniramine: Histamine H1 antagonist used in treatment of allergies, rhinitis, and urticaria.. brompheniramine : Pheniramine in which the hydrogen at position 4 of the phenyl substituent is substituted by bromine. A histamine H1 receptor antagonist, brompheniramine is used (commonly as its maleate salt) for the symptomatic relief of allergic conditions, including rhinitis and conjunctivitis.	3.23	1	0	organobromine compound; pyridines	anti-allergic agent; H1-receptor antagonist
acriflavine chloride 3,6-diamino-10-methylacridinium chloride : The 10-methochloride salt of 3,6-diaminoacridine. Note that a mixture of this compound with 3,6-diaminoacridine (proflavine) is known as acriflavine or neutral acriflavine.	2.46	2	0	organic chloride salt	antibacterial agent; antiseptic drug; carcinogenic agent; histological dye; intercalator
carbazole carbazole: structure in first source	2.41	1	0	carbazole
penicillin v Penicillin V: A broad-spectrum penicillin antibiotic used orally in the treatment of mild to moderate infections by susceptible gram-positive organisms.. phenoxymethylpenicillin : A penicillin compound having a 6beta-(phenoxyacetyl)amino side-chain.	15.92	106	2	penicillin allergen; penicillin
isosorbide dinitrate Isosorbide Dinitrate: A vasodilator used in the treatment of ANGINA PECTORIS. Its actions are similar to NITROGLYCERIN but with a slower onset of action.	3.85	3	0	glucitol derivative; nitrate ester	nitric oxide donor; vasodilator agent
penicillanic acid Penicillanic Acid: A building block of penicillin, devoid of significant antibacterial activity. (From Merck Index, 11th ed). penicillanic acid : A penam that consists of 3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane bearing a carboxy group at position 2 and having (2S,5R)-configuration.	8.98	14	0	penicillanic acids
thymol Thymol: A phenol obtained from thyme oil or other volatile oils used as a stabilizer in pharmaceutical preparations, and as an antiseptic (antibacterial or antifungal) agent.. thymol : A phenol that is a natural monoterpene derivative of cymene.	2.05	1	0	monoterpenoid; phenols	volatile oil component
pseudoephedrine Pseudoephedrine: A phenethylamine that is an isomer of EPHEDRINE which has less central nervous system effects and usage is mainly for respiratory tract decongestion.. pseudoephedrine : A member of the class of the class of phenylethanolamines that is (1S)-2-(methylamino)-1-phenylethan-1-ol in which the pro-S hydrogen at position 2 is replaced by a methyl group.	3.58	2	0	phenylethanolamines; secondary alcohol; secondary amino compound	anti-asthmatic drug; bronchodilator agent; central nervous system drug; nasal decongestant; plant metabolite; sympathomimetic agent; vasoconstrictor agent; xenobiotic
diethylpropion Diethylpropion: A appetite depressant considered to produce less central nervous system disturbance than most drugs in this therapeutic category. It is also considered to be among the safest for patients with hypertension. (From AMA Drug Evaluations Annual, 1994, p2290). diethylpropion : An aromatic ketone that is propiophenone in which one of the hydrogens alpha- to the carbonyl is substituted by a diethylamino group. A central stimulant and indirect-acting sympathomimetic, it is an appetite depressant and is used as the hydrochloride as an anoretic in the short term management of obesity.	3.23	1	0	aromatic ketone; tertiary amine	appetite depressant
quinoxalines quinoxaline : A naphthyridine in which the nitrogens are at positions 1 and 4.	2.08	1	0	mancude organic heterobicyclic parent; naphthyridine; ortho-fused heteroarene
pyronine Pyronine: Xanthene dye used as a bacterial and biological stain. Synonyms: Pyronin; Pyronine G; Pyronine Y. Use also for Pyronine B. which is diethyl-rather than dimethylamino-.. pyronin Y : An organic chloride salt having 6-(dimethylamino)-N,N-dimethyl-3H-xanthen-3-iminium as the cation. Used with methyl green to selectively demonstrate RNA (red) in contrast to DNA (green) with the Unna-Pappenheim method.	2.05	1	0	iminium salt; organic chloride salt	histological dye
proflavine Proflavine: Topical antiseptic used mainly in wound dressings.. 3,6-diaminoacridine : An aminoacridine that is acridine that is substituted by amino groups at positions 3 and 6. A slow-acting bacteriostat that is effective against many Gram-positive bacteria (but ineffective against spores), its salts were formerly used for treatment of burns and infected wounds.	2.07	1	0	aminoacridines	antibacterial agent; antiseptic drug; carcinogenic agent; chromophore; intercalator
xanthenes Xanthenes: Compounds with three aromatic rings in linear arrangement with an OXYGEN in the center ring.	2.7	3	0	xanthene
fenoprop fenoprop: RN given is for parent cpd; structure	2.04	1	0	monocarboxylic acid	phenoxy herbicide
propylparaben Parabens: Methyl, propyl, butyl, and ethyl esters of p-hydroxybenzoic acid. They have been approved by the FDA as antimicrobial agents for foods and pharmaceuticals. (From Hawley's Condensed Chemical Dictionary, 11th ed, p872)	1.95	1	0	benzoate ester; paraben; phenols	antifungal agent; antimicrobial agent
2-methyl-4-chlorophenoxyacetic acid 2-Methyl-4-chlorophenoxyacetic Acid: A powerful herbicide used as a selective weed killer.. (4-chloro-2-methylphenoxy)acetic acid : A chlorophenoxyacetic acid that is (4-chlorophenoxy)acetic acid substituted by a methyl group at position 2.	2.04	1	0	chlorophenoxyacetic acid; monochlorobenzenes	environmental contaminant; phenoxy herbicide; synthetic auxin
methyl gallate methyl gallate: has both immunosuppressive and phytogenic antineoplastic activities; isolated from Acer saccharinum. methyl 3,4,5-trihydroxybenzoate : A gallate ester obtained by the formal condensation of gallic acid with methanol. It exhibits anti-oxidant, anti-tumor, anti-microbial and anti-inflammatory properties.	2.02	1	0	gallate ester	anti-inflammatory agent; antioxidant; plant metabolite
dicloran 2,6-dichloro-4-nitroaniline : A nitroaniline that is 4-nitroaniline in which the hydrogens at positions 2 and 6 are replaced by chlorines. An agricultural fungicide, it is not approved for use in the European Union.	2.04	1	0	aromatic fungicide; dichlorobenzene; nitroaniline	antifungal agrochemical
phenylhydrazine [no description available]	2.04	1	0	phenylhydrazines	xenobiotic
dyrene dyrene: structure. anilazine : A member of the class of triazenes that is dichlorotriazene in which the hydrogen is replaced by an o-chloroanilino group. A fungicide formerly used to control leaf spots and downy mildew, it is no longer approved for use within the European Union.	2.04	1	0	monochlorobenzenes; organochlorine pesticide; secondary amino compound; triazines	antifungal agrochemical
benzonatate benzonatate: structure in Merck Index, 9th ed, #1107. benzonatate : The ester obtained by formal condensation of 4-butylaminobenzoic acid with nonaethylene glycol monomethyl ether. Structurally related to procaine and benzocaine, it has an anaesthetic effect on the stretch sensors in the lungs, and is used as a non-narcotic cough suppressant.	3.23	1	0	benzoate ester; secondary amino compound; substituted aniline	anaesthetic; antitussive
acrolein [no description available]	2.04	1	0	enal	herbicide; human xenobiotic metabolite; toxin
2-methylpentane Hexanes: Six-carbon saturated hydrocarbon group of the methane series. Include isomers and derivatives. Various polyneuropathies are caused by hexane poisoning.	2.11	1	0	alkane
3,5-xylenol 3,5-xylenol: RN given refers to 3,5-isomer. 3,5-xylenol : A member of the class of phenols that phenol substituted by methyl groups at positions 3 and 5.	2.01	1	0	phenols	xenobiotic metabolite
thiophenes Thiophenes: A monocyclic heteroarene furan in which the oxygen atom is replaced by a sulfur.. thiophenes : Compounds containing at least one thiophene ring.	1.94	1	0	mancude organic heteromonocyclic parent; monocyclic heteroarene; thiophenes; volatile organic compound	non-polar solvent
n-hexane hexane : An unbranched alkane containing six carbon atoms.	2.11	1	0	alkane; volatile organic compound	neurotoxin; non-polar solvent
1-hexanol 1-hexanol: RN given refers to parent cpd. hexanol : A fatty alcohol consisting of a hydroxy function at any position of an unbranched saturated chain of six carbon atoms.. hexan-1-ol : A primary alcohol that is hexane substituted by a hydroxy group at position 1.	2.11	1	0	hexanol; primary alcohol	alarm pheromone; antibacterial agent; fragrance; plant metabolite
dodecyltrimethylammonium dodecyltrimethylammonium: used to determine thermal stability of DNA; RN given refers to parent cpd. dodecyltrimethylammonium ion : A quarternary ammonium cation having one dodecyl and three methyl substituents around the central nitrogen.	2.02	1	0	quaternary ammonium ion
n-decyl alcohol n-decyl alcohol: RN given refers to parent cpd. decanol : A fatty alcohol consisting of a hydroxy function at any position of an unbranched saturated chain of ten carbon atoms.. decan-1-ol : A fatty alcohol consisting of a hydroxy function at C-1 of an unbranched saturated chain of ten carbon atoms.	2.11	1	0	decanol; primary alcohol	metabolite; pheromone; protic solvent
dodecanol Dodecanol: A saturated 12-carbon fatty alcohol obtained from coconut oil fatty acids. It has a floral odor and is used in detergents, lubricating oils, and pharmaceuticals. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed). dodecanol : A fatty alcohol consisting of a hydroxy function at any position of an unbranched saturated chain of twelve carbon atoms.. dodecan-1-ol : A primary alcohol that is dodecane in which a hydrogen from one of the methyl groups is replaced by a hydroxy group. It is registered for use in apple and pear orchards as a Lepidopteran pheromone/sex attractant, used to disrupt the mating behaviour of certain moths whose larvae destroy crops.	2.11	1	0	dodecanol; primary alcohol	bacterial metabolite; cosmetic; insect attractant; insecticide; pheromone; plant metabolite
tetraethylenepentamine [no description available]	2.04	1	0	polyazaalkane	copper chelator
myristyl alcohol myristyl alcohol: RN given refers to parent cpd. tetradecan-1-ol : A long-chain fatty alcohol that is tetradecane substituted by a hydroxy group at position 1.. tetradecanol : A fatty alcohol consisting of a hydroxy function at any position of an unbranched saturated chain of fourteen carbon atoms.	2.11	1	0	long-chain primary fatty alcohol; tetradecanol	pheromone; plant metabolite; volatile oil component
stearyl alcohol octadecan-1-ol : A long-chain primary fatty alcohol consisting of a hydroxy function at C-1 of an unbranched saturated chain of 18 carbon atoms.. octadecanol : A fatty alcohol consisting of a hydroxy function at any position of an unbranched saturated chain of eighteen carbon atoms.	2.11	1	0	long-chain primary fatty alcohol; octadecanol	algal metabolite; human metabolite; plant metabolite
ergotamine Ergotamine: A vasoconstrictor found in ergot of Central Europe. It is a serotonin agonist that has been used as an oxytocic agent and in the treatment of MIGRAINE DISORDERS.. ergotamine : A peptide ergot alkaloid that is dihydroergotamine in which a double bond replaces the single bond between positions 9 and 10.	2.44	2	0	peptide ergot alkaloid	alpha-adrenergic agonist; mycotoxin; non-narcotic analgesic; oxytocic; serotonergic agonist; vasoconstrictor agent
methylergonovine Methylergonovine: A homolog of ERGONOVINE containing one more CH2 group. (Merck Index, 11th ed)	3.23	1	0	ergoline alkaloid
neostigmine bromide neostigmine bromide : The bromide salt of neostigmine.	2.04	1	0	bromide salt
oxyphenisatin acetate Oxyphenisatin Acetate: A laxative that undergoes enterohepatic circulation. It may cause jaundice.	3.06	1	0	benzoate ester; phenols
chloranil Chloranil: A quinone fungicide used for treatment of seeds and foliage.. tetrachloro-1,4-benzoquinone : A member of the class of 1,4-benzoquiones that is 1,4-benzoquinone in which all four hydrogens are substituted by chlorines.	2.04	1	0	1,4-benzoquinones; organochlorine compound	EC 2.7.1.33 (pantothenate kinase) inhibitor; metabolite
framycetin Framycetin: A component of NEOMYCIN that is produced by Streptomyces fradiae. On hydrolysis it yields neamine and neobiosamine B. (From Merck Index, 11th ed). framycetin : A tetracyclic antibacterial agent derived from neomycin, being a glycoside ester of neamine and neobiosamine B.	8.66	46	2	aminoglycoside	allergen; antibacterial drug; Escherichia coli metabolite
cinchophen cinchophen: was heading 1963-94; ACIPHENOCHINOLIUM was see CHINOPHEN 1978-94; use QUINOLINES to search CINCHOPHEN 1966-94	3.23	1	0	quinolines
amiben Amiben: RN given refers to parent cpd	2.04	1	0	chlorobenzoic acid
benzathine benzathine: RN given refers to parent cpd with specified locants for phenylmethyl groups; structure	3.44	2	0	diamine
monuron monuron: minor descriptor (72-83); on-line & Index Medicus search UREA/AA (72-74) & HERBICIDES (72-74) & HERBICIDES UREA (75-83); RN given refers to unlabeled cpd; structure. monuron : A member of the class of 3-(3,4-substituted-phenyl)-1,1-dimethylureas that is urea in which one of the nitrogens is substituted by a p-chlorophenyl group while the other is substituted by two methyl groups.	2.04	1	0	3-(3,4-substituted-phenyl)-1,1-dimethylurea; monochlorobenzenes	environmental contaminant; herbicide; xenobiotic
iminodiacetic acid iminodiacetic acid: used as hepatobiliary imaging agent when labeled with Tc; RN given refers to parent cpd; structure. iminodiacetic acid : An amino dicarboxylic acid that is glycine in which one of the hydrogens attached to the nitrogen is substituted by a carboxymethyl group.	2.04	1	0	amino dicarboxylic acid; glycine derivative; non-proteinogenic alpha-amino acid	chelator
nafcillin Nafcillin: A semi-synthetic antibiotic related to penicillin.. nafcillin : A penicillin in which the substituent at position 6 of the penam ring is a (2-ethoxy-1-naphthoyl)amino group.	11.03	118	2	penicillin allergen; penicillin	antibacterial drug
methohexital Methohexital: An intravenous anesthetic with a short duration of action that may be used for induction of anesthesia.. methohexital : A barbiturate, the structure of which is that of barbituric acid substituted at N-1 by a methyl group and at C-5 by allyl and 1-methylpent-2-ynyl groups.	3.58	2	0	acetylenic compound; barbiturates	drug allergen; intravenous anaesthetic
catechin Catechin: An antioxidant flavonoid, occurring especially in woody plants as both (+)-catechin and (-)-epicatechin (cis) forms.. catechin : Members of the class of hydroxyflavan that have a flavan-3-ol skeleton and its substituted derivatives.. rac-catechin : A racemate comprising equimolar amounts of (+)- and (-)-catechin. (+)-catechin : The (+)-enantiomer of catechin and a polyphenolic antioxidant plant metabolite.	3.83	11	0	catechin	antioxidant; plant metabolite
phenetidine Phenetidine: Used in the manufacture of acetophenetidin.. 4-ethoxyaniline : An aromatic ether that is aniline in which the hydrogen at position 4 is replaced by an ethoxy group. It is a hydrolysis metabolite of phenacetin.	2.04	1	0	aromatic ether; primary amino compound; substituted aniline	drug metabolite
diazooxonorleucine Diazooxonorleucine: An amino acid that inhibits phosphate-activated glutaminase and interferes with glutamine metabolism. It is an antineoplastic antibiotic produced by an unidentified species of Streptomyces from Peruvian soil. (From Merck Index, 11th ed). 6-diazo-5-oxo-L-norleucine : A non-proteinogenic L-alpha-amino acid that is L-norleucine which is substituted at position 5 by an oxo group and at position 6 by a diazo group. It is as inhibitor of various glutamine-utilising enzymes.	2.04	1	0	amino acid zwitterion; diazo compound; ketone; non-proteinogenic L-alpha-amino acid	analgesic; antibacterial agent; antimetabolite; antineoplastic agent; antiviral agent; apoptosis inducer; bacterial metabolite; EC 2.4.2.14 (amidophosphoribosyltransferase) inhibitor; EC 3.5.1.2 (glutaminase) inhibitor; EC 6.3.4.2 [CTP synthase (glutamine hydrolyzing)] inhibitor; EC 6.3.5.1 [NAD(+) synthase (glutamine-hydrolysing)] inhibitor; EC 6.3.5.2 [GMP synthase (glutamine-hydrolysing)] inhibitor; EC 6.3.5.3 (phosphoribosylformylglycinamidine synthase) inhibitor; EC 6.3.5.4 [asparagine synthase (glutamine-hydrolysing)] inhibitor; EC 6.3.5.5 [carbamoyl-phosphate synthase (glutamine-hydrolysing)] inhibitor; glutamine antagonist
quinazolines Quinazolines: A group of aromatic heterocyclic compounds that contain a bicyclic structure with two fused six-membered aromatic rings, a benzene ring and a pyrimidine ring.. quinazoline : A mancude organic heterobicyclic parent that is naphthalene in which the carbon atoms at positions 1 and 3 have been replaced by nitrogen atoms.. quinazolines : Any organic heterobicyclic compound based on a quinazoline skeleton and its substituted derivatives.	2.13	1	0	azaarene; mancude organic heterobicyclic parent; ortho-fused heteroarene; quinazolines
acridines Acridines: Compounds that include the structure of acridine.. acridine : A polycyclic heteroarene that is anthracene in which one of the central CH groups is replaced by a nitrogen atom.	4.43	5	1	acridines; mancude organic heterotricyclic parent; polycyclic heteroarene	genotoxin
isoxazoles Isoxazoles: Azoles with an OXYGEN and a NITROGEN next to each other at the 1,2 positions, in contrast to OXAZOLES that have nitrogens at the 1,3 positions.. isoxazole : A monocyclic heteroarene with a structure consisting of a 5-membered ring containing three carbon atoms and an oxygen and nitrogen atom adjacent to each other. It is the parent of the class of isoxazoles.. isoxazoles : Oxazoles in which the N and O atoms are adjacent.	7.94	4	0	isoxazoles; mancude organic heteromonocyclic parent; monocyclic heteroarene
oxazoles Oxazoles: Five-membered heterocyclic ring structures containing an oxygen in the 1-position and a nitrogen in the 3-position, in distinction from ISOXAZOLES where they are at the 1,2 positions.. 1,3-oxazole : A five-membered monocyclic heteroarene that is an analogue of cyclopentadiene with O in place of CH2 at position 1 and N in place of CH at position 3.. oxazole : An azole based on a five-membered heterocyclic aromatic skeleton containing one N and one O atom.	6.48	14	0	1,3-oxazoles; mancude organic heteromonocyclic parent; monocyclic heteroarene
thiazoles [no description available]	3.2	6	0	1,3-thiazoles; mancude organic heteromonocyclic parent; monocyclic heteroarene
ephedrine Ephedrine: A phenethylamine found in EPHEDRA SINICA. PSEUDOEPHEDRINE is an isomer. It is an alpha- and beta-adrenergic agonist that may also enhance release of norepinephrine. It has been used for asthma, heart failure, rhinitis, and urinary incontinence, and for its central nervous system stimulatory effects in the treatment of narcolepsy and depression. It has become less extensively used with the advent of more selective agonists.. (-)-ephedrine : A phenethylamine alkaloid that is 2-phenylethanamine substituted by a methyl group at the amino nitrogen and a methyl and a hydroxy group at position 2 and 1 respectively.	3.48	2	0	phenethylamine alkaloid; phenylethanolamines	bacterial metabolite; environmental contaminant; nasal decongestant; plant metabolite; sympathomimetic agent; vasoconstrictor agent; xenobiotic
chlormadinone acetate Chlormadinone Acetate: An orally active synthetic progestational hormone used often in combinations as an oral contraceptive (CONTRACEPTIVES, ORAL).	1.95	1	0	corticosteroid hormone
pirinitramide Pirinitramide: A diphenylpropylamine with intense narcotic analgesic activity of long duration. It is a derivative of MEPERIDINE with similar activity and usage.	2.45	2	0	nitrile
methylpentynol carbamate [no description available]	2.04	1	0
mechlorethamine n-oxide [no description available]	2.04	1	0	nitrogen mustard
edrophonium bromide [no description available]	2.04	1	0
aminophylline Aminophylline: A drug combination that contains THEOPHYLLINE and ethylenediamine. It is more soluble in water than theophylline but has similar pharmacologic actions. It's most common use is in bronchial asthma, but it has been investigated for several other applications.. aminophylline : A mixture comprising of theophylline and ethylenediamine in a 2:1 ratio.	3.49	2	0	mixture	bronchodilator agent; cardiotonic drug
azacitidine Azacitidine: A pyrimidine analogue that inhibits DNA methyltransferase, impairing DNA methylation. It is also an antimetabolite of cytidine, incorporated primarily into RNA. Azacytidine has been used as an antineoplastic agent.. 5-azacytidine : An N-glycosyl-1,3,5-triazine that is 4-amino-1,3,5-triazin-2(1H)-one substituted by a beta-D-ribofuranosyl residue via an N-glycosidic linkage. An antineoplastic agent, it is used in the treatment of myeloid leukaemia.	3.85	3	0	N-glycosyl-1,3,5-triazine; nucleoside analogue	antineoplastic agent
linuron Linuron: A selective pre- and post-emergence herbicide. (From Merck Index, 11th ed). linuron : A member of the class of phenylureas that is N-methyl urea substituted by a methoxy group at position 1 and a 3,4-dichlorophenyl group at position 3.	2.04	1	0	dichlorobenzene; phenylureas	agrochemical; environmental contaminant; herbicide; xenobiotic
carbutamide Carbutamide: A sulfonylurea antidiabetic agent with similar actions and uses to CHLORPROPAMIDE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p277)	2.04	1	0	benzenes; sulfonamide
galantamine Galantamine: A benzazepine derived from norbelladine. It is found in GALANTHUS and other AMARYLLIDACEAE. It is a cholinesterase inhibitor that has been used to reverse the muscular effects of GALLAMINE TRIETHIODIDE and TUBOCURARINE and has been studied as a treatment for ALZHEIMER DISEASE and other central nervous system disorders.. galanthamine : A benzazepine alkaloid isolated from certain species of daffodils.	3.85	3	0	benzazepine alkaloid fundamental parent; benzazepine alkaloid; organic heterotetracyclic compound; tertiary amino compound	antidote to curare poisoning; cholinergic drug; EC 3.1.1.7 (acetylcholinesterase) inhibitor; EC 3.1.1.8 (cholinesterase) inhibitor; plant metabolite
nandrolone decanoate Nandrolone Decanoate: Decanoic acid ester of nandrolone that is used as an anabolic agent to prevent or treat WASTING SYNDROME associated with severe chronic illness or HIV infection (HIV WASTING SYNDROME). It may also be used in the treatment of POSTMENOPAUSAL OSTEOPOROSIS.	3.23	1	0	steroid ester
betamethasone Betamethasone: A glucocorticoid given orally, parenterally, by local injection, by inhalation, or applied topically in the management of various disorders in which corticosteroids are indicated. Its lack of mineralocorticoid properties makes betamethasone particularly suitable for treating cerebral edema and congenital adrenal hyperplasia. (From Martindale, The Extra Pharmacopoeia, 30th ed, p724)	2.94	4	0	11beta-hydroxy steroid; 17alpha-hydroxy steroid; 20-oxo steroid; 21-hydroxy steroid; 3-oxo-Delta(1),Delta(4)-steroid; fluorinated steroid; glucocorticoid; primary alpha-hydroxy ketone; tertiary alpha-hydroxy ketone	anti-asthmatic agent; anti-inflammatory drug; immunosuppressive agent
hydantoins Hydantoins: Compounds based on imidazolidine dione. Some derivatives are ANTICONVULSANTS.. imidazolidine-2,4-dione : An imidazolidinone with oxo groups at position 2 and 4.	2.04	1	0	imidazolidine-2,4-dione
dextropropoxyphene Dextropropoxyphene: A narcotic analgesic structurally related to METHADONE. Only the dextro-isomer has an analgesic effect; the levo-isomer appears to exert an antitussive effect.. propoxyphene : A racemate of the (1R,2R)- and (1S,2R)- diastereoisomers.. dextropropoxyphene : The (1S,2R)-(+)-diastereoisomer of propoxyphene.	3.83	3	0	1-benzyl-3-(dimethylamino)-2-methyl-1-phenylpropyl propanoate	mu-opioid receptor agonist; opioid analgesic
ketobemidone ketobemidone: structure	2.04	1	0	piperidines
chenodeoxycholic acid Chenodeoxycholic Acid: A bile acid, usually conjugated with either glycine or taurine. It acts as a detergent to solubilize fats for intestinal absorption and is reabsorbed by the small intestine. It is used as cholagogue, a choleretic laxative, and to prevent or dissolve gallstones.. chenodeoxycholic acid : A dihydroxy-5beta-cholanic acid that is (5beta)-cholan-24-oic acid substituted by hydroxy groups at positions 3 and 7 respectively.. chenodeoxycholate : Conjugate base of chenodeoxycholic acid; major species at pH 7.3.	3.23	1	0	bile acid; C24-steroid; dihydroxy-5beta-cholanic acid	human metabolite; mouse metabolite
rhein [no description available]	7.08	1	0	dihydroxyanthraquinone
plumbagin plumbagin: a superoxide anion generator. plumbagin : A hydroxy-1,4-naphthoquinone that is 1,4-naphthoquinone in which the hydrogens at positions 2 and 5 are substituted by methyl and hydroxy groups, respectively.	7.73	3	0	hydroxy-1,4-naphthoquinone; phenols	anticoagulant; antineoplastic agent; immunological adjuvant; metabolite
emetine Emetine: The principal alkaloid of ipecac, from the ground roots of Uragoga (or Cephaelis) ipecacuanha or U. acuminata, of the Rubiaceae. It is used as an amebicide in many different preparations and may cause serious cardiac, hepatic, or renal damage and violent diarrhea and vomiting. Emetine inhibits protein synthesis in EUKARYOTIC CELLS but not PROKARYOTIC CELLS.. emetine : A pyridoisoquinoline comprising emetam having methoxy substituents at the 6'-, 7'-, 10- and 11-positions. It is an antiprotozoal agent and emetic. It inhibits SARS-CoV2, Zika and Ebola virus replication and displays antimalarial, antineoplastic and antiamoebic properties.	2.04	1	0	isoquinoline alkaloid; pyridoisoquinoline	antiamoebic agent; anticoronaviral agent; antiinfective agent; antimalarial; antineoplastic agent; antiprotozoal drug; antiviral agent; autophagy inhibitor; emetic; expectorant; plant metabolite; protein synthesis inhibitor
flavanone flavanone: RN given refers to cpd with unspecified isomeric designation; structure in first source. flavanone : The simplest member of the class of flavanones that consists of flavan bearing an oxo substituent at position 4.	2.1	1	0	flavanones
thymoquinone thymoquinone: constituent of cedarwood; can cause dermatitis; structure. thymoquinone : A member of the class of 1,4-benzoquinones that is 1,4-bezoquinone in which the hydrogens at positions 2 and 5 are replaced by methyl and isopropyl groups, respectively. It is a natural compound isolated from Nigella sativa which has demonstrated promising chemotherapeutic activity.	2.1	1	0	1,4-benzoquinones	adjuvant; anti-inflammatory agent; antidepressant; antineoplastic agent; antioxidant; cardioprotective agent; plant metabolite
pamaquine pamaquine: structure; RN given refers to parent cpd	2.04	1	0	aminoquinoline
thioxanthone thioxanthone: structure in first source	7.11	1	0
carvacrol carvacrol : A phenol that is a natural monoterpene derivative of cymene. An inhibitor of bacterial growth, it is used as a food additive. Potent activator of the human ion channels transient receptor potential V3 (TRPV3) and A1 (TRPA1).	7.15	1	0	botanical anti-fungal agent; p-menthane monoterpenoid; phenols	agrochemical; antimicrobial agent; flavouring agent; TRPA1 channel agonist; volatile oil component
olivetol olivetol: from cannabidiol by pyrolysis; structure. olivetol : A member of the class of resorcinols that is resorcinol in which the hydrogen at position 5 is replaced by a pentyl group.	2.04	1	0	resorcinols	lichen metabolite
indophenol Indophenol: A deep blue dye (with the formula OC6H4NC6H4OH) used to detect AMMONIA in a common test called the Berthelot's reaction and to detect PARACETAMOL by spectrophotometry.. indophenol : A quinone imine obtained by formal condensation of one of the keto groups of benzoquinone with the amino group of 4-hydroxyaniline.	1.94	1	0	quinone imine	dye
4-hydroxybutyric acid 4-hydroxybutyric acid: was an entry term to Sodium Oxybate (74-98). 4-hydroxybutyric acid : A 4-hydroxy monocarboxylic acid that is butyric acid in which one of the hydrogens at position 4 is replaced by a hydroxy group.	3.23	1	0	4-hydroxy monocarboxylic acid; hydroxybutyric acid	general anaesthetic; GHB receptor agonist; neurotoxin; sedative
mustard gas Mustard Gas: Severe irritant and vesicant of skin, eyes, and lungs. It may cause blindness and lethal lung edema and was formerly used as a war gas. The substance has been proposed as a cytostatic and for treatment of psoriasis. It has been listed as a known carcinogen in the Fourth Annual Report on Carcinogens (NTP-85-002, 1985) (Merck, 11th ed).. bis(2-chloroethyl) sulfide : An ethyl sulfide that is diethyl sulfide in which a hydrogen from each of the terminal methyl groups is replaced by a chlorine. It is a powerful vesicant regulated under the Chemical Weapons Convention.	2.04	1	0	ethyl sulfide; organochlorine compound	alkylating agent; carcinogenic agent; vesicant
oleanolic acid [no description available]	2.21	1	0	hydroxy monocarboxylic acid; pentacyclic triterpenoid	plant metabolite
dihydroergotamine Dihydroergotamine: A 9,10alpha-dihydro derivative of ERGOTAMINE. It is used as a vasoconstrictor, specifically for the therapy of MIGRAINE DISORDERS.. dihydroergotamine : Ergotamine in which a single bond replaces the double bond between positions 9 and 10. A semisynthetic ergot alkaloid with weaker oxytocic and vasoconstrictor properties than ergotamine, it is used (as the methanesulfonic or tartaric acid salts) for the treatment of migraine and orthostatic hypotension.	3.23	1	0	ergot alkaloid; semisynthetic derivative	dopamine agonist; non-narcotic analgesic; serotonergic agonist; sympatholytic agent; vasoconstrictor agent
hesperidin Hesperidin: A flavanone glycoside found in CITRUS fruit peels.. hesperidin : A disaccharide derivative that consists of hesperetin substituted by a 6-O-(alpha-L-rhamnopyranosyl)-beta-D-glucopyranosyl moiety at position 7 via a glycosidic linkage.	2.47	2	0	3'-hydroxyflavanones; 4'-methoxyflavanones; dihydroxyflavanone; disaccharide derivative; flavanone glycoside; monomethoxyflavanone; rutinoside	mutagen
medroxyprogesterone [no description available]	3.58	2	0	17alpha-hydroxy steroid; 20-oxo steroid; 3-oxo-Delta(4) steroid; tertiary alpha-hydroxy ketone	contraceptive drug; progestin; synthetic oral contraceptive
dimenhydrinate gravinol: has antioxidant and ant-inflammatory activities; structure in first source	3.23	1	0	diarylmethane
copper gluconate Gluconates: Derivatives of gluconic acid (the structural formula HOCH2(CHOH)4COOH), including its salts and esters.	1.95	1	0	organic molecular entity
apronalide apronalide: structure	2.04	1	0	N-acylurea
chlormethiazole Chlormethiazole: A sedative and anticonvulsant often used in the treatment of alcohol withdrawal. Chlormethiazole has also been proposed as a neuroprotective agent. The mechanism of its therapeutic activity is not entirely clear, but it does potentiate GAMMA-AMINOBUTYRIC ACID receptors response and it may also affect glycine receptors.	2.72	3	0	thiazoles
4,6-dinitro-o-cresol 4,6-dinitro-o-cresol: RN given refers to parent cpd; structure. 4,6-dinitro-o-cresol : A hydroxytoluene that is o-cresol carrying nitro substituents at positions 4 and 6.	2.04	1	0	dinitrophenol acaricide; hydroxytoluene; nitrotoluene	dinitrophenol insecticide; fungicide; herbicide
methamphetamine Methamphetamine: A central nervous system stimulant and sympathomimetic with actions and uses similar to DEXTROAMPHETAMINE. The smokable form is a drug of abuse and is referred to as crank, crystal, crystal meth, ice, and speed.. methamphetamine : A member of the class of amphetamines in which the amino group of (S)-amphetamine carries a methyl substituent.	3.58	2	0	amphetamines; secondary amine	central nervous system stimulant; environmental contaminant; neurotoxin; psychotropic drug; xenobiotic
dicyclohexylcarbodiimide 1,3-dicyclohexylcarbodiimide : A carbodiimide compound having a cyclohexyl substituent on both nitrogen atoms.	2.31	1	0	carbodiimide	ATP synthase inhibitor; cross-linking reagent; peptide coupling reagent
levocarnitine (R)-carnitine : The (R)-enantiomer of carnitine.	3.23	1	0	carnitine	antilipemic drug; nootropic agent; nutraceutical; Saccharomyces cerevisiae metabolite; water-soluble vitamin (role)
n-hexadecane n-hexadecane: structure. hexadecane : A straight-chain alkane with 16 carbon atoms. It is a component of essential oil isolated from long pepper.	1.98	1	0	long-chain alkane	non-polar solvent; plant metabolite; volatile oil component
sulfanilylurea sulfanilylurea: antimicrobial agent; structure	3.23	1	0	benzenes; sulfonamide
gentian violet Gentian Violet: A dye that is a mixture of violet rosanilinis with antibacterial, antifungal, and anthelmintic properties.. crystal violet : An organic chloride salt that is the monochloride salt of crystal violet cation. It has been used in creams for the topical treatment of bacterial and fungal infections, being effective against some Gram-positive bacteria (notably Staphylococcus species) and some pathogenic fungi (including Candida species) but use declined following reports of animal carcinogenicity. It has also been used for dying wood, silk, and paper, as well as a histological stain.	2.51	2	0	organic chloride salt	anthelminthic drug; antibacterial agent; antifungal agent; antiseptic drug; histological dye
resazurin resazurin: used as indicator in detection of hyposulfite (sulfoxylate); in food research (reductase test); structure	2.7	3	0	phenoxazine
aminopenicillanic acid aminopenicillanic acid: RN given refers to parent cpd; structure. 6-aminopenicillanic acid : A penicillanic acid compound having a (6R)-amino substituent. The active nucleus common to all penicillins, it may be substituted at the 6-amino position to form the semisynthetic penicillins, resulting in a variety of antibacterial and pharmacologic characteristics.	2.73	3	0	amino acid zwitterion; penicillanic acids	allergen
lithium carbonate Lithium Carbonate: A lithium salt, classified as a mood-stabilizing agent. Lithium ion alters the metabolism of BIOGENIC MONOAMINES in the CENTRAL NERVOUS SYSTEM, and affects multiple neurotransmission systems.	2.04	1	0	carbonate salt; lithium salt	antimanic drug
glycylglycine [no description available]	2.44	2	0	dipeptide zwitterion; dipeptide	human metabolite
4-methyl-1-(1-methylethyl)-3-cyclohexen-1-ol 4-methyl-1-(1-methylethyl)-3-cyclohexen-1-ol: structure in first source. 4-terpineol : A terpineol that is 1-menthene carrying a hydroxy substituent at position 4.	2.15	1	0	terpineol; tertiary alcohol	anti-inflammatory agent; antibacterial agent; antineoplastic agent; antioxidant; antiparasitic agent; apoptosis inducer; plant metabolite; volatile oil component
metahexamide metahexamide: major descriptor (64-83); on-line search SULFONYLUREA COMPOUNDS (64-83); Index Medicus search METAHEXAMIDE (64-83); RN given refers to parent cpd; structure	2.04	1	0	benzenes; sulfonamide
congo red Congo Red: An acid dye used in testing for hydrochloric acid in gastric contents. It is also used histologically to test for AMYLOIDOSIS.. Congo Red : An indicator dye that is blue-violet at pH 3.0 and red at pH 5.0.	2.11	1	0	bis(azo) compound
lactulose [no description available]	3.23	1	0	glycosylfructose	gastrointestinal drug; laxative
toluene 2,4-diisocyanate Toluene 2,4-Diisocyanate: Skin irritant and allergen used in the manufacture of polyurethane foams and other elastomers.. toluene 2,4-diisocyanate : A toluene meta-diisocyanate in which the isocyanato groups are at positions 2 and 4 relative to the methyl group on the benzene ring.	1.95	1	0	toluene meta-diisocyanate	allergen; hapten
levulinic acid levulinic acid: inhibits 5-aminolevulinic acid dehydratase; RN given refers to parent cpd; structure in Merck Index, 9th ed, #5316. 4-oxopentanoic acid : An oxopentanoic acid with the oxo group in the 4-position.	2.06	1	0	oxopentanoic acid; straight-chain saturated fatty acid	plant metabolite
megestrol acetate [no description available]	2.04	1	0	20-oxo steroid; 3-oxo-Delta(4) steroid; acetate ester; steroid ester	antineoplastic agent; appetite enhancer; contraceptive drug; progestin; synthetic oral contraceptive
pamabrom [no description available]	3.23	1	0
toyocamycin Toyocamycin: 4-Amino-5-cyano-7-(D-ribofuranosyl)-7H- pyrrolo(2,3-d)pyrimidine. Antibiotic antimetabolite isolated from Streptomyces toyocaensis cultures. It is an analog of adenosine, blocks RNA synthesis and ribosome function, and is used mainly as a tool in biochemistry.. toyocamycin : An N-glycosylpyrrolopyrimidine that is tubercidin in which the hydrogen at position 5 of the pyrrolopyrimidine moiety has been replaced by a cyano group.	2.04	1	0	antibiotic antifungal agent; N-glycosylpyrrolopyrimidine; nitrile; ribonucleoside	antimetabolite; antineoplastic agent; apoptosis inducer; bacterial metabolite
acetylcysteine N-acetyl-L-cysteine : An N-acetyl-L-amino acid that is the N-acetylated derivative of the natural amino acid L-cysteine.	3.89	3	0	acetylcysteine; L-cysteine derivative; N-acetyl-L-amino acid	antidote to paracetamol poisoning; antiinfective agent; antioxidant; antiviral drug; ferroptosis inhibitor; geroprotector; human metabolite; mucolytic; radical scavenger; vulnerary
methyl isocyanate methyl isocyanate: structure. methyl isocyanate : The isocyanate that is methane modified by a single isocyanato substituent.	2.6	1	0	isocyanates	allergen; apoptosis inducer
6-methyluracil 6-methyluracil: RN given refers to unlabeled cpd; structure. 6-methyluracil : A pyrimidone that is uracil with a methyl group at position 6.	1.96	1	0	pyrimidone	metabolite
erythromycin Erythromycin: A bacteriostatic antibiotic macrolide produced by Streptomyces erythreus. Erythromycin A is considered its major active component. In sensitive organisms, it inhibits protein synthesis by binding to 50S ribosomal subunits. This binding process inhibits peptidyl transferase activity and interferes with translocation of amino acids during translation and assembly of proteins.. erythromycin : Any of several wide-spectrum macrolide antibiotics obtained from actinomycete Saccharopolyspora erythraea (formerly known as Streptomyces erythraeus).. erythromycin A : An erythromycin that consists of erythronolide A having 2,6-dideoxy-3-C-methyl-3-O-methyl-alpha-L-ribo-hexopyranosyl and 3,4,6-trideoxy-3-(dimethylamino)-beta-D-xylo-hexopyranosyl residues attahced at positions 4 and 6 respectively.	11.54	220	3	cyclic ketone; erythromycin
nitrosoguanidines Nitrosoguanidines: Nitrosylated derivatives of guanidine. They are used as MUTAGENS in MOLECULAR BIOLOGY research.	2.37	2	0
hadacidin hadacidin: inhibitor of AMP synthesis; RN given refers to parent cpd; structure. hadacidin : A monocarboxylic acid that is N-hydroxyglycine in which the hydrogen attached to the nitrogen is replaced by a formyl group. It was originally isolated from cultures of Penicillium frequentans.	2.04	1	0	aldehyde; monocarboxylic acid; N-hydroxy-alpha-amino-acid	antimicrobial agent; antineoplastic agent; Penicillium metabolite; teratogenic agent
carbophenothion carbophenothion: structure	2.04	1	0	organic sulfide
levonorgestrel Levonorgestrel: A synthetic progestational hormone with actions similar to those of PROGESTERONE and about twice as potent as its racemic or (+-)-isomer (NORGESTREL). It is used for contraception, control of menstrual disorders, and treatment of endometriosis.	3.58	2	0	17beta-hydroxy steroid; 3-oxo-Delta(4) steroid; terminal acetylenic compound	contraceptive drug; female contraceptive drug; progestin; synthetic oral contraceptive
porfiromycin Porfiromycin: Toxic antibiotic of the mitomycin group, obtained from MITOMYCIN and also from Streptomyces ardus and other species. It is proposed as an antineoplastic agent, with some antibiotic properties.	2.04	1	0
lormetazepam lormetazepam: RN given refers to cpd with specified locant for methyl group; structure given in first source. lormetazepam : A 1,4-benzodiazepinone compound having a methyl substituent at the 1-position, a hydroxy substituent at the 3-position, a 2-chlorophenyl group at the 5-position and a chloro substituent at the 7-position.	2.45	2	0	1,4-benzodiazepinone; organochlorine compound	sedative
vinblastine [no description available]	2.73	3	0
diphenoxylate Diphenoxylate: A MEPERIDINE congener used as an antidiarrheal, usually in combination with ATROPINE. At high doses, it acts like morphine. Its unesterified metabolite difenoxin has similar properties and is used similarly. It has little or no analgesic activity.. diphenoxylate : A piperidinecarboxylate ester that is the ethyl ester of difenoxin.	3.23	1	0	ethyl ester; nitrile; piperidinecarboxylate ester; tertiary amine	antidiarrhoeal drug
deoxyuridine [no description available]	2.04	1	0	pyrimidine 2'-deoxyribonucleoside	Escherichia coli metabolite; human metabolite; mouse metabolite; Saccharomyces cerevisiae metabolite
testolactone Testolactone: An antineoplastic agent that is a derivative of progesterone and used to treat advanced breast cancer.	2.04	1	0	3-oxo-Delta(1),Delta(4)-steroid; seco-androstane
ethambutol Ethambutol: An antitubercular agent that inhibits the transfer of mycolic acids into the cell wall of the tubercle bacillus. It may also inhibit the synthesis of spermidine in mycobacteria. The action is usually bactericidal, and the drug can penetrate human cell membranes to exert its lethal effect. (From Smith and Reynard, Textbook of Pharmacology, 1992, p863). ethambutol : An ethylenediamine derivative that is ethane-1,2-diamine in which one hydrogen attached to each of the nitrogens is sutstituted by a 1-hydroxybutan-2-yl group (S,S-configuration). It is a bacteriostatic antimycobacterial drug, effective against Mycobacterium tuberculosis and some other mycobacteria. It is used (as the dihydrochloride salt) in combination with other antituberculous drugs in the treatment of pulmonary and extrapulmonary tuberculosis; resistant strains of M. tuberculosis are readily produced if ethambutol is used alone.	4.63	8	0	ethanolamines; ethylenediamine derivative	antitubercular agent; environmental contaminant; xenobiotic
pyrithioxin Pyrithioxin: A neurotropic agent which reduces permeability of blood-brain barrier to phosphate. It has no vitamin B6 activity.	2.04	1	0	methylpyridines
tetradecyltrimethylammonium tetradecyltrimethylammonium: cationic surfactant; used to determine thermal stability of DNA; Catrimox-14 is the tradename of the oxalate; Catrimox-14 lyses cells and simultaneously precipitates RNA and was demonstrated useful in isolating RNA from whole blood	2.02	1	0
3,3',4',5-tetrachlorosalicylanilide 3,3',4',5-tetrachlorosalicylanilide : A salicylanilide derivative with chloride substituents at C-3 and C-5 of the salicylate moiety and at C-3 and C-4 of the anilide moiety.	2.4	2	0	dichlorobenzene; salicylanilides	drug allergen
ethidium bromide [no description available]	2.99	4	0	organic bromide salt	geroprotector; intercalator; trypanocidal drug
durapatite Durapatite: The mineral component of bones and teeth; it has been used therapeutically as a prosthetic aid and in the prevention and treatment of osteoporosis.. hydroxylapatite : A phosphate mineral with the formula Ca5(PO4)3(OH).	1.96	1	0
zinc oxide Zinc Oxide: A mild astringent and topical protectant with some antiseptic action. It is also used in bandages, pastes, ointments, dental cements, and as a sunblock.	2.21	1	0	zinc molecular entity
vancomycin Vancomycin: Antibacterial obtained from Streptomyces orientalis. It is a glycopeptide related to RISTOCETIN that inhibits bacterial cell wall assembly and is toxic to kidneys and the inner ear.. vancomycin : A complex glycopeptide from Streptomyces orientalis. It inhibits a specific step in the synthesis of the peptidoglycan layer in the Gram-positive bacteria Staphylococcus aureus and Clostridium difficile.	14.22	293	6	glycopeptide	antibacterial drug; antimicrobial agent; bacterial metabolite
nsc 65346 sangivamycin: RN given refers to parent cpd. sangivamycin : A nucleoside analogue that is adenosine in which the nitrogen at position 7 is replaced by a carbamoyl-substituted carbon. It is a potent inhibitor of protein kinase C.	2.04	1	0	nucleoside analogue	protein kinase inhibitor
d-alpha tocopherol Vitamin E: A generic descriptor for all TOCOPHEROLS and TOCOTRIENOLS that exhibit ALPHA-TOCOPHEROL activity. By virtue of the phenolic hydrogen on the 2H-1-benzopyran-6-ol nucleus, these compounds exhibit varying degree of antioxidant activity, depending on the site and number of methyl groups and the type of ISOPRENOIDS.. tocopherol : A collective name for a group of closely related lipids that contain a chroman-6-ol nucleus substituted at position 2 by a methyl group and by a saturated hydrocarbon chain consisting of three isoprenoid units. They are designated as alpha-, beta-, gamma-, and delta-tocopherol depending on the number and position of additional methyl substituents on the aromatic ring. Tocopherols occur in vegetable oils and vegetable oil products, almost exclusively with R,R,R configuration. Tocotrienols differ from tocopherols only in having three double bonds in the hydrocarbon chain.. vitamin E : Any member of a group of fat-soluble chromanols that exhibit biological activity against vitamin E deficiency. The vitamers in this class consists of a chroman-6-ol core which is substituted at position 2 by a methyl group and (also at position 2) either a saturated or a triply-unsaturated hydrocarbon chain consisting of three isoprenoid units. The major function of vitamin E is to act as a natural antioxidant by scavenging free radicals and molecular oxygen.. (R,R,R)-alpha-tocopherol : An alpha-tocopherol that has R,R,R configuration. The naturally occurring stereoisomer of alpha-tocopherol, it is found particularly in sunflower and olive oils.	3.23	1	0	alpha-tocopherol	algal metabolite; antiatherogenic agent; anticoagulant; antioxidant; antiviral agent; EC 2.7.11.13 (protein kinase C) inhibitor; immunomodulator; micronutrient; nutraceutical; plant metabolite
guanazole Guanazole: A cytostatic triazole derivative which is not to be confused with guanazolo, the generic name for 8-azaguanine.. guanazole : An aromatic amine that is 1,2,4-triazole substituted at positions 3 and 5 by amino groups.	2.04	1	0	aromatic amine; triazoles	antineoplastic agent; DNA synthesis inhibitor; EC 1.17.4.1 (ribonucleoside-diphosphate reductase) inhibitor
ibufenac ibufenac: used in the treatment of rheumatism; also possesses antipyretic properties; minor descriptor (75-84); on-line & Index Medicus search PHENYLACETATES (75-84); RN given refers to parent cpd. ibufenac : A monocarboxylic acid that is acetic acid in which one of the methyl hydrogens is replaced by a 4-isobutylphenyl group. Although it was shown to be effective in treatment of rheumatoid arthritis, the clinical use of ibufenac was discontinued due to hepatotoxic side-effects.	3.23	1	0	monocarboxylic acid	EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor; hepatotoxic agent; non-narcotic analgesic; non-steroidal anti-inflammatory drug
metylperon metylperon: RN given refers to parent cpd	2.04	1	0	aromatic ketone
meturedepa meturedepa: structure in Merck Index, 9th ed, #6031	2.04	1	0	phosphoramide
metaxalone [no description available]	3.23	1	0	aromatic ether
ioxynil ioxynil: RN given refers to parent cpd; structure. ioxynil : A nitrile that is benzonitrile substituted by a hydroxy group at position 4 and iodo groups at positions 3 and 5.	2.04	1	0	iodophenol; nitrile	environmental contaminant; herbicide; xenobiotic
bromoxynil bromoxynil: RN given refers to parent cpd; structure. 3,5-dibromo-4-hydroxybenzonitrile : A dibromobenzene that is 2,6-dibromophenol substituted by a cyano group at position 4.	2.04	1	0	dibromobenzene; hydroxynitrile; phenols	environmental contaminant; herbicide; xenobiotic
spectinomycin Spectinomycin: An antibiotic produced by Streptomyces spectabilis. It is active against gram-negative bacteria and used for the treatment of GONORRHEA.. spectinomycin dihydrochloride : A hydrochloride obtained by combining spectinomycin with two molar equivalents of hydrochloric acid. An antibiotic that is active against gram-negative bacteria and used (as its pentahydrate) to treat gonorrhea.. spectinomycin : A pyranobenzodioxin and antibiotic that is active against gram-negative bacteria and used (as its dihydrochloride pentahydrate) to treat gonorrhea. It is produced by the bacterium Streptomyces spectabilis.	4.42	6	0	cyclic acetal; cyclic hemiketal; cyclic ketone; pyranobenzodioxin; secondary alcohol; secondary amino compound	antibacterial drug; antimicrobial agent; bacterial metabolite
picloram Picloram: A picolinic acid derivative that is used as a herbicide.. picloram : A pyridinemonocarboxylic acid that is pyridine-2-carboxylic acid which is substituted by a chloro group at positions 3,5 and 6, and by an amino group at position 4. It is a systemic herbicide used to control deeply rooted herbaceous weeds and woody plants in rights-of-way, forestry, range lands, pastures, and small grain crops.	2.04	1	0	aminopyridine; chloropyridine; organochlorine pesticide; pyridinemonocarboxylic acid	herbicide; synthetic auxin
2'-deoxyadenosine triphosphate 2'-deoxyadenosine triphosphate: RN given refers to unlabeled parent cpd	1.98	1	0	2'-deoxyadenosine 5'-phosphate; purine 2'-deoxyribonucleoside 5'-triphosphate	Escherichia coli metabolite; mouse metabolite
tetrabutylammonium tetrabutylammonium: lipophilic probe; RN given refers to parent cpd	2.07	1	0	quaternary ammonium ion
ethoglucid Ethoglucid: Alkylating antineoplastic agent used especially in bladder neoplasms. It is toxic to hair follicles, gastro-intestinal tract, and vasculature.	2.04	1	0	epoxide
dronabinol Dronabinol: A psychoactive compound extracted from the resin of Cannabis sativa (marihuana, hashish). The isomer delta-9-tetrahydrocannabinol (THC) is considered the most active form, producing characteristic mood and perceptual changes associated with this compound.. Delta(9)-tetrahydrocannabinol : A diterpenoid that is 6a,7,8,10a-tetrahydro-6H-benzo[c]chromene substituted at position 1 by a hydroxy group, positions 6, 6 and 9 by methyl groups and at position 3 by a pentyl group. The principal psychoactive constituent of the cannabis plant, it is used for treatment of anorexia associated with AIDS as well as nausea and vomiting associated with cancer chemotherapy.	4.05	4	0	benzochromene; diterpenoid; phytocannabinoid; polyketide	cannabinoid receptor agonist; epitope; hallucinogen; metabolite; non-narcotic analgesic
amiloride Amiloride: A pyrazine compound inhibiting SODIUM reabsorption through SODIUM CHANNELS in renal EPITHELIAL CELLS. This inhibition creates a negative potential in the luminal membranes of principal cells, located in the distal convoluted tubule and collecting duct. Negative potential reduces secretion of potassium and hydrogen ions. Amiloride is used in conjunction with DIURETICS to spare POTASSIUM loss. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p705). amiloride : A member of the class of pyrazines resulting from the formal monoacylation of guanidine with the carboxy group of 3,5-diamino-6-chloropyrazine-2-carboxylic acid.	3.54	2	0	aromatic amine; guanidines; organochlorine compound; pyrazines	diuretic; sodium channel blocker
pimozide Pimozide: A diphenylbutylpiperidine that is effective as an antipsychotic agent and as an alternative to HALOPERIDOL for the suppression of vocal and motor tics in patients with Tourette syndrome. Although the precise mechanism of action is unknown, blockade of postsynaptic dopamine receptors has been postulated. (From AMA Drug Evaluations Annual, 1994, p403). pimozide : A member of the class of benzimidazoles that is 1,3-dihydro-2H-benzimidazol-2-one in which one of the nitrogens is substituted by a piperidin-4-yl group, which in turn is substituted on the nitrogen by a 4,4-bis(p-fluorophenyl)butyl group.	3.54	2	0	benzimidazoles; heteroarylpiperidine; organofluorine compound	antidyskinesia agent; dopaminergic antagonist; first generation antipsychotic; H1-receptor antagonist; serotonergic antagonist
benperidol Benperidol: A butyrophenone with general properties similar to those of HALOPERIDOL. It has been used in the treatment of aberrant sexual behavior. (From Martindale, The Extra Pharmacopoeia, 30th ed, p567)	2.04	1	0	aromatic ketone
decyltrimethylammonium decyltrimethylammonium ion : A quarternary ammonium cation having one decyl and three methyl substituents around the central nitrogen.	2.02	1	0	quaternary ammonium ion
2,4-diacetylphloroglucinol 2,4-diacetylphloroglucinol: produced by Pseudomonas aurantiaca. 2,4-diacetylphloroglucinol : A benzenetriol that is phloroglucinol in which two of the ring hydrogens are replaced by acetyl groups.	2.6	1	0	aromatic ketone; benzenetriol; diketone; methyl ketone	antifungal agent; bacterial metabolite
azaribine azaribine: pyrimidine analogue; anti-metabolite used in psoriasis & mycosis fungoides;. azaribine : A N-glycosyl-1,2,4-triazine that is 6-azauridine acetylated at positions 2', 3' and 5' on the sugar ring. It is a prodrug for 6-azauridine and is used for treatment of psoriasis.	2.04	1	0	acetate ester; N-glycosyl-1,2,4-triazine	antipsoriatic; prodrug
dexbrompheniramine dexbrompheniramine : The (pharmacologically active) (S)-(+)-enantiomer of brompheniramine. A histamine H1 receptor antagonist, it is used (commonly as its maleate salt) for the symptomatic relief of allergic conditions, including rhinitis and conjunctivitis.	3.23	1	0	brompheniramine	anti-allergic agent; H1-receptor antagonist
alpha-methyldopamine [no description available]	3.06	1	0	amphetamines
1,3,5-triglycidyl-s-triazinetrione [no description available]	2.04	1	0
etridiazol etridiazol: structure. etridiazole : A member of the class of thiadiazoles that is 1,2,4-thiadiazole which is substituted at positions 3 and 5 by trichloromethyl and ethoxy groups, respectively. A fungicide, it has been used particularly for the control of Phytophthora and Pythium species in soils.	1.96	1	0	aromatic ether; organochlorine compound; thiadiazole antifungal agent; thiadiazoles	antifungal agrochemical; nitrification inhibitor
acetophenazine acetophenazine: major descriptor (73-85); minor descriptor (64-72); on-line search PHENOTHIAZINES (64-85); Index Medicus search PHENOTHIAZINES (64-72); ACETOPHENAZINE (73-85); RN given refers to parent cpd. acetophenazine : A member of the class of phenothiazines that is 10H-phenothiazine substituted by a 3-[4-(2-hydroxyethyl)piperazin-1-yl]propyl group at the nitogen atom and an acetyl group at position 2.	2.04	1	0	N-(2-hydroxyethyl)piperazine; N-alkylpiperazine; phenothiazines	phenothiazine antipsychotic drug
chlordesmethyldiazepam [no description available]	2.04	1	0	benzodiazepine
stavudine Stavudine: A dideoxynucleoside analog that inhibits reverse transcriptase and has in vitro activity against HIV.. stavudine : A nucleoside analogue obtained by formal dehydration across positions 2 and 3 of thymidine. An inhibitor of HIV-1 reverse transcriptase	3.85	3	0	dihydrofuran; nucleoside analogue; organic molecular entity	antimetabolite; antiviral agent; EC 2.7.7.49 (RNA-directed DNA polymerase) inhibitor
doxifluridine doxifluridine : A pyrimidine 5'-deoxyribonucleoside that is 5-fluorouridine in which the hydroxy group at the 5' position is replaced by a hydrogen. It is an oral prodrug of the antineoplastic agent 5-fluorouracil. Designed to circumvent the rapid degradation of 5-fluorouracil by dihydropyrimidine dehydrogenase in the gut wall, it is converted into 5-fluorouracil in the presence of pyrimidine nucleoside phosphorylase.	2.94	4	0	organofluorine compound; pyrimidine 5'-deoxyribonucleoside	antimetabolite; antineoplastic agent; prodrug
dicloxacillin Dicloxacillin: One of the PENICILLINS which is resistant to PENICILLINASE.. dicloxacillin : A penicillin that is 6-aminopenicillanic acid in which one of the amino hydrogens is replaced by a 3-(2,6-dichlorophenyl)-5-methyl-1,2-oxazol-4-yl]formyl group.	12.12	121	3	dichlorobenzene; penicillin	antibacterial drug
fluorescein-5-isothiocyanate Fluorescein-5-isothiocyanate: Fluorescent probe capable of being conjugated to tissue and proteins. It is used as a label in fluorescent antibody staining procedures as well as protein- and amino acid-binding techniques.. fluorescein 5-isothiocyanate : The 5-isomer of fluorescein isothiocyanate. Acts as a fluorescent probe capable of being conjugated to tissue and proteins; used as a label in fluorescent antibody staining procedures as well as protein- and amino acid-binding techniques.	2.02	1	0	fluorescein isothiocyanate
sabinene sabinene: RN given refers to cpd without isomeric designation. sabinene : A thujene that is a bicyclic monoterpene isolated from the essential oils of various plant species.	2.15	1	0	thujene	plant metabolite
improsan improsan: synonyms NSC-102627, alkylating agent 864 & yoshi 864 refer to HCl; RN given refers to parent cpd; structure	2.04	1	0	organosulfonic ester
cyclacillin Cyclacillin: A cyclohexylamido analog of PENICILLANIC ACID.	2.73	3	0	penicillin	antibacterial drug
megestrol Megestrol: A progestational hormone used most commonly as the acetate ester. As the acetate, it is more potent than progesterone both as a progestagen and as an ovulation inhibitor. It has also been used in the palliative treatment of breast cancer.. megestrol : A 3-oxo Delta(4)-steroid that is pregna-4,6-diene-3,20-dione substituted by a methyl group at position 6 and a hydroxy group at position 17.	3.23	1	0	17alpha-hydroxy steroid; 20-oxo steroid; 3-oxo-Delta(4) steroid; tertiary alpha-hydroxy ketone	antineoplastic agent; appetite enhancer; contraceptive drug; progestin; synthetic oral contraceptive
cephaloglycin Cephaloglycin: A cephalorsporin antibiotic.. cefaloglycin : A cephalosporin antibiotic containing at the 7beta-position of the cephem skeleton an (R)-amino(phenyl)acetamido group.	3.45	2	0	beta-lactam antibiotic allergen; cephalosporin	antimicrobial agent
streptomycin [no description available]	10.2	109	3	antibiotic antifungal drug; antibiotic fungicide; streptomycins	antibacterial drug; antifungal agrochemical; antimicrobial agent; antimicrobial drug; bacterial metabolite; protein synthesis inhibitor
piperacetazine piperacetazine: was MH 1975-91 (see under PHENOTHIAZINE TRANQUILIZERS 1975-90)	2.04	1	0	phenothiazines
cladribine [no description available]	3.85	3	0	organochlorine compound; purine 2'-deoxyribonucleoside	antineoplastic agent; immunosuppressive agent
beclomethasone [no description available]	2.04	1	0	11beta-hydroxy steroid; 17alpha-hydroxy steroid; 20-oxo steroid; 21-hydroxy steroid; 3-oxo-Delta(1),Delta(4)-steroid; chlorinated steroid; corticosteroid; glucocorticoid; primary alpha-hydroxy ketone; tertiary alpha-hydroxy ketone	anti-asthmatic drug; anti-inflammatory drug
carbenicillin Carbenicillin: Broad-spectrum semisynthetic penicillin derivative used parenterally. It is susceptible to gastric juice and penicillinase and may damage platelet function.. carbenicillin : A penicillin antibiotic having a 6beta-2-carboxy-2-phenylacetamido side-chain.	9.72	77	1	penicillin allergen; penicillin	antibacterial drug
floxacillin Floxacillin: Antibiotic analog of CLOXACILLIN.. flucloxacillin : A penicillin compound having a 6beta-[3-(2-chloro-6-fluorophenyl)-5-methyl-1,2-oxazole-4-carboxamido] side-chain.	5.16	15	0	penicillin allergen; penicillin	antibacterial drug
clomacran clomacran: RN given refers to parent cpd; structure	3.23	1	0	acridines
pentaquine pentaquine: RN given refers to parent cpd	2.04	1	0
dihydrostreptomycin sulfate Dihydrostreptomycin Sulfate: A semi-synthetic aminoglycoside antibiotic that is used in the treatment of TUBERCULOSIS.	3.04	5	0
beclomethasone dipropionate beclomethasone dipropionate : A steroid ester comprising beclomethasone having propionyl groups at the 17- and 21-positions.	2.04	1	0	11beta-hydroxy steroid; 20-oxo steroid; 3-oxo-Delta(1),Delta(4)-steroid; chlorinated steroid; corticosteroid; enone; glucocorticoid; propanoate ester; steroid ester	anti-arrhythmia drug; anti-asthmatic drug; anti-inflammatory drug; prodrug
cephalonium cephalonium: used in treatment of bovine mastitis; Cepravin D.C. contains 250 mg cephalonium	1.95	1	0	cephalosporin
iodinated glycerol iodinated glycerol: secretolytic agent; RN given refers to cpd without iodine locant	2	1	0	dioxolane
methenamine hippurate methenamine hippurate: both parts of molecule contribute to its antibacterial action	3.23	1	0	N-acylglycine
limonene Limonene: A naturally-occurring class of MONOTERPENES which occur as a clear colorless liquid at room temperature. Limonene is the major component in the oil of oranges which has many uses, including as flavor and fragrance. It is recognized as safe in food by the Food and Drug Administration (FDA).. limonene : A monoterpene that is cyclohex-1-ene substituted by a methyl group at position 1 and a prop-1-en-2-yl group at position 4 respectively.	2.15	1	0	cycloalkene; p-menthadiene	human metabolite
olsalazine olsalazine: cpd with 2 salicylate molecules linked together by an azo bond. olsalazine : An azobenzene that consists of two molecules of 4-aminosalicylic acid joined by an azo linkage. A prodrug for mesalazine, an anti-inflammatory drug, it is used (as the disodium salt) in the treatment of inflammatory bowel disease.	3.58	2	0	azobenzenes; dicarboxylic acid	non-steroidal anti-inflammatory drug; prodrug
terodiline [no description available]	2.45	2	0	diarylmethane
1-(4-carboxyphenyl)-3,3-dimethyltriazene 1-(4-carboxyphenyl)-3,3-dimethyltriazene: RN given refers to parent cpd	2.04	1	0
hepes [no description available]	2.04	1	0	HEPES; organosulfonic acid
mercury Mercury: A silver metallic element that exists as a liquid at room temperature. It has the atomic symbol Hg (from hydrargyrum, liquid silver), atomic number 80, and atomic weight 200.59. Mercury is used in many industrial applications and its salts have been employed therapeutically as purgatives, antisyphilitics, disinfectants, and astringents. It can be absorbed through the skin and mucous membranes which leads to MERCURY POISONING. Because of its toxicity, the clinical use of mercury and mercurials is diminishing.. mercury(0) : Elemental mercury of oxidation state zero.	1.94	1	0	elemental mercury; zinc group element atom	neurotoxin
palladium Palladium: A chemical element having an atomic weight of 106.4, atomic number of 46, and the symbol Pd. It is a white, ductile metal resembling platinum, and following it in abundance and importance of applications. It is used in dentistry in the form of gold, silver, and copper alloys.. palladium : Chemical element (nickel group element atom) with atomic number 46.	2.1	1	0	metal allergen; nickel group element atom; platinum group metal atom
silver Silver: An element with the atomic symbol Ag, atomic number 47, and atomic weight 107.87. It is a soft metal that is used medically in surgical instruments, dental prostheses, and alloys. Long-continued use of silver salts can lead to a form of poisoning known as ARGYRIA.	1.97	1	0	copper group element atom; elemental silver	Escherichia coli metabolite
technetium Technetium: The first artificially produced element and a radioactive fission product of URANIUM. Technetium has the atomic symbol Tc, and atomic number 43. All technetium isotopes are radioactive. Technetium 99m (m=metastable) which is the decay product of Molybdenum 99, has a half-life of about 6 hours and is used diagnostically as a radioactive imaging agent. Technetium 99 which is a decay product of technetium 99m, has a half-life of 210,000 years.	1.97	1	0	manganese group element atom
titanium Titanium: A dark-gray, metallic element of widespread distribution but occurring in small amounts with atomic number, 22, atomic weight, 47.867 and symbol, Ti; specific gravity, 4.5; used for fixation of fractures.	2.63	2	0	titanium group element atom
cerium Cerium: An element of the rare earth family of metals. It has the atomic symbol Ce, atomic number 58, and atomic weight 140.12. Cerium is a malleable metal used in industrial applications.	7.39	2	0	f-block element atom; lanthanoid atom
gold Gold: A yellow metallic element with the atomic symbol Au, atomic number 79, and atomic weight 197. It is used in jewelry, goldplating of other metals, as currency, and in dental restoration. Many of its clinical applications, such as ANTIRHEUMATIC AGENTS, are in the form of its salts.	3.06	1	0	copper group element atom; elemental gold
zalcitabine Zalcitabine: A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by a hydrogen. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. The compound is a potent inhibitor of HIV replication at low concentrations, acting as a chain-terminator of viral DNA by binding to reverse transcriptase. Its principal toxic side effect is axonal degeneration resulting in peripheral neuropathy.. zalcitabine : A pyrimidine 2',3'-dideoxyribonucleoside compound having cytosine as the nucleobase.	2.72	3	0	pyrimidine 2',3'-dideoxyribonucleoside	antimetabolite; antiviral drug; HIV-1 reverse transcriptase inhibitor
acetylglucosamine Acetylglucosamine: The N-acetyl derivative of glucosamine.. N-acetyl-beta-D-glucosamine : An N-acetyl-D-glucosamine having beta-configuration at the anomeric centre.	2.07	1	0	N-acetyl-D-glucosamine	epitope
metocurine iodide [no description available]	2.45	2	0	aromatic ether
isopentenyladenosine Isopentenyladenosine: N(6)-[delta(3)-isopentenyl]adenosine. Isopentenyl derivative of adenosine which is a member of the cytokinin family of plant growth regulators.. N(6)-(Delta(2)-isopentenyl)adenosine : A nucleoside analogue in which adenosine has been modified by substitution at the 6-amino nitrogen by a Delta(2)-isopentenyl group.	2.04	1	0	N-ribosyl-N(6)-isopentenyladenine; nucleoside analogue	antineoplastic agent; plant growth regulator; plant metabolite
ferrous chloride ferrous chloride: induces convulsions; RN given refers to parent cpd	2.07	1	0	iron coordination entity
silver nitrate Silver Nitrate: A silver salt with powerful germicidal activity. It has been used topically to prevent OPHTHALMIA NEONATORUM.	2.64	3	0	inorganic nitrate salt; silver salt	astringent
sodium thiosulfate sodium thiosulfate: do not confuse synonym sodium hyposulfite with sodium hyposulfite, synonym for di-Na salt of dithionous acid. sodium thiosulfate : An inorganic sodium salt composed of sodium and thiosulfate ions in a 2:1 ratio.	3.23	1	0	inorganic sodium salt	antidote to cyanide poisoning; antifungal drug; nephroprotective agent
deuterium Deuterium: The stable isotope of hydrogen. It has one neutron and one proton in the nucleus.	1.95	1	0	dihydrogen
fluorine Fluorine: A nonmetallic, diatomic gas that is a trace element and member of the halogen family. It is used in dentistry as fluoride (FLUORIDES) to prevent dental caries.	1.95	1	0	diatomic fluorine; gas molecular entity	NMR chemical shift reference compound
chlorine Chlorine: An element with atomic symbol Cl, atomic number 17, and atomic weight 35, and member of the halogen family.	1.95	1	0	diatomic chlorine; gas molecular entity	bleaching agent
tellurous acid tellurous acid: tellurite anion inhibits oxidation of NAD-linked substrates in kidney & liver mitochondria; RN given refers to parent cpd	2	1	0	tellurium oxoacid
ancitabine Ancitabine: Congener of CYTARABINE that is metabolized to cytarabine and thereby maintains a more constant antineoplastic action.. ancitabine : An organic heterotricyclic compound resulting from the formal condensation of the oxo group of cytidine to the 2' position with loss of water to give the corresponding cyclic ether. A prodrug, it is metabolised to the antineoplastic agent cytarabine, so is used to maintain a more constant antineoplastic action.	2.04	1	0	diol; organic heterotricyclic compound	antimetabolite; antineoplastic agent; prodrug
trolamine salicylate Arthritis: Acute or chronic inflammation of JOINTS.	3.97	5	0
phenacid phenacid: RN given refers to parent cpd; structure	2.04	1	0
titanium dioxide titanium dioxide: used medically as protectant against externally caused irritation & sunlight; high concentrations of dust may cause irritation to respiratory tract; RN given refers to titanium oxide (TiO2); structure. titanium dioxide : A titanium oxide with the formula TiO2. A naturally occurring oxide sourced from ilmenite, rutile and anatase, it has a wide range of applications.	2.13	1	0	titanium oxides	food colouring
sodium tungstate(vi) sodium tungstate(VI): inactivates molybdoenzymes in Anabaena; RN given refers to tungstic acid [H2WO4], di-Na salt. sodium tungstate : An inorganic sodium salt having tungstate as the counterion. Combines with hydrogen peroxide for the oxidation of secondary amines to nitrones.	2	1	0	inorganic sodium salt	reagent
apazone Apazone: An anti-inflammatory agent used in the treatment of rheumatoid arthritis. It also has uricosuric properties and has been used to treat gout.. apazone : A member of the class of benzotriazines that is 1,2-dihydro-1,2,4-benzotriazine bearing a dimethylamino substitutent at position 3 and a methyl substituent at position 7 and in which the nitrogens at positions 1 and 2 are both acylated by a carboxy group of propylmalonic acid.	2.04	1	0	benzotriazines	non-steroidal anti-inflammatory drug; uricosuric drug
xipamide Xipamide: A sulfamoylbenzamide analog of CLOPAMIDE. It is diuretic and saluretic with antihypertensive activity. It is bound to PLASMA PROTEINS, thus has a delayed onset and prolonged action.	2.04	1	0	benzamides
selegiline Selegiline: A selective, irreversible inhibitor of Type B monoamine oxidase that is used for the treatment of newly diagnosed patients with PARKINSON DISEASE, and for the treatment of depressive disorders. The compound without isomeric designation is Deprenyl.	4.24	5	0	selegiline; terminal acetylenic compound	geroprotector
clemastine Clemastine: A histamine H1 antagonist used as the hydrogen fumarate in hay fever, rhinitis, allergic skin conditions, and pruritus. It causes drowsiness.. clemastine : 2-[(2R)-1-Methylpyrrolidin-2-yl]ethanol in which the hydrogen of the hydroxy group is substituted by a 1-(4-chlorophenyl)-1-phenylethyl group (R configuration). An antihistamine with antimuscarinic and moderate sedative properties, it is used as its fumarate salt for the symptomatic relief of allergic conditions such as rhinitis, urticaria, conjunctivitis and in pruritic (severe itching) skin conditions.	3.87	3	0	monochlorobenzenes; N-alkylpyrrolidine	anti-allergic agent; antipruritic drug; H1-receptor antagonist; muscarinic antagonist
cephalexin Cephalexin: A semisynthetic cephalosporin antibiotic with antimicrobial activity similar to that of CEPHALORIDINE or CEPHALOTHIN, but somewhat less potent. It is effective against both gram-positive and gram-negative organisms.. cephalexin : A semisynthetic first-generation cephalosporin antibiotic having methyl and beta-(2R)-2-amino-2-phenylacetamido groups at the 3- and 7- of the cephem skeleton, respectively. It is effective against both Gram-negative and Gram-positive organisms, and is used for treatment of infections of the skin, respiratory tract and urinary tract.	6.1	23	0	beta-lactam antibiotic allergen; cephalosporin; semisynthetic derivative	antibacterial drug
isosorbide-5-mononitrate isosorbide-5-mononitrate: for prevention of angina pectoris; structure given in first source; a Russian drug	2.73	3	0	glucitol derivative; nitrate ester	nitric oxide donor; vasodilator agent
pentamethylmelamine pentamethylmelamine: RN given refers to parent cpd	2.04	1	0
calusterone calusterone: was MH 1975-92 (see under METHYLTESTOSTERONE 1975-90); use METHYLTESTOSTERONE to search CALUSTERONE 1975-92	2.04	1	0	3-hydroxy steroid	androgen
danazol Danazol: A synthetic steroid with antigonadotropic and anti-estrogenic activities that acts as an anterior pituitary suppressant by inhibiting the pituitary output of gonadotropins. It possesses some androgenic properties. Danazol has been used in the treatment of endometriosis and some benign breast disorders.	3.58	2	0	17beta-hydroxy steroid; terminal acetylenic compound	anti-estrogen; estrogen antagonist; geroprotector
fenclozic acid fenclozic acid: an analgesic & antipyretic with anti-inflammatory properties; minor descriptor (75-86); on-line & INDEX MEDICUS search THIAZOLES (75-86); RN given refers to parent cpd	3.23	1	0
lisuride Lisuride: An ergot derivative that acts as an agonist at dopamine D2 receptors (DOPAMINE AGONISTS). It may also act as an antagonist at dopamine D1 receptors, and as an agonist at some serotonin receptors (SEROTONIN RECEPTOR AGONISTS).	2.04	1	0	monocarboxylic acid amide	antidyskinesia agent; antiparkinson drug; dopamine agonist; serotonergic agonist
etoprine etoprine: do not confuse with 3,5-dicarbethoxy-2,6-dimethyl-4-ethyl-1,4-dihydropyridine, also called DDEP	2.04	1	0
laxagetten 4,4'-diacetoxydiphenylpyridylemethane [no description available]	3.23	1	0
taurolidine [no description available]	2.92	1	0	thiadiazinane
iodine [no description available]	1.94	1	0	halide anion; monoatomic iodine	human metabolite
cannabichromene [no description available]	2.04	1	0	1-benzopyran
daunorubicin Daunorubicin: A very toxic anthracycline aminoglycoside antineoplastic isolated from Streptomyces peucetius and others, used in treatment of LEUKEMIA and other NEOPLASMS.. anthracycline : Anthracyclines are polyketides that have a tetrahydronaphthacenedione ring structure attached by a glycosidic linkage to the amino sugar daunosamine.. daunorubicin : A natural product found in Actinomadura roseola.	4.06	4	0	aminoglycoside antibiotic; anthracycline; p-quinones; tetracenequinones	antineoplastic agent; bacterial metabolite
razoxane Razoxane: An antimitotic agent with immunosuppressive properties.	2.04	1	0	N-alkylpiperazine
cephapirin Cephapirin: Cephalosporin antibiotic, partly plasma-bound, that is effective against gram-negative and gram-positive organisms.. cephapirin : A cephalosporin with acetoxymethyl and 2(pyridin-4-ylsulfanyl)acetamido substituents at positions 3 and 7, respectively, of the cephem skeleton. It is used (as its sodium salt) as an antibiotic, being effective against gram-negative and gram-positive organisms.	3.27	6	0	cephalosporin	antibacterial drug
fludarabine phosphate fludarabine phosphate: structure given in first source. fludarabine phosphate : A purine arabinonucleoside monophosphate having 2-fluoroadenine as the nucleobase. A prodrug, it is rapidly dephosphorylated to 2-fluoro-ara-A and then phosphorylated intracellularly by deoxycytidine kinase to the active triphosphate, 2-fluoro-ara-ATP. Once incorporated into DNA, 2-fluoro-ara-ATP functions as a DNA chain terminator. It is used for the treatment of adult patients with B-cell chronic lymphocytic leukemia (CLL) who have not responded to, or whose disease has progressed during, treatment with at least one standard alkylating-agent containing regimenas.	3.58	2	0	nucleoside analogue; organofluorine compound; purine arabinonucleoside monophosphate	antimetabolite; antineoplastic agent; antiviral agent; DNA synthesis inhibitor; immunosuppressive agent; prodrug
alclofenac alclofenac: was heading 1975-94 (was see under PHENYLACETATES 1975-90); use PHENYLACETATES to search ALCLOFENAC 1975-94; an anti-inflammatory agent used in the treatment of rheumatoid arthritis; acts also as an analgesic and an antipyretic. alclofenac : An aromatic ether in which the ether oxygen links an allyl group to the 4-position of (3-chlorophenyl)acetic acid.A non-steroidal anti-inflammatory drug, it was withdrawn from the UK market in 1979 due to concerns with its association with vasculitis and rash.	3.23	1	0	aromatic ether; monocarboxylic acid; monochlorobenzenes	drug allergen; non-narcotic analgesic; non-steroidal anti-inflammatory drug
bromocriptine Bromocriptine: A semisynthetic ergotamine alkaloid that is a dopamine D2 agonist. It suppresses prolactin secretion.	3.58	2	0	indole alkaloid	antidyskinesia agent; antiparkinson drug; dopamine agonist; hormone antagonist
triamcinolone Triamcinolone: A glucocorticoid given, as the free alcohol or in esterified form, orally, intramuscularly, by local injection, by inhalation, or applied topically in the management of various disorders in which corticosteroids are indicated. (From Martindale, The Extra Pharmacopoeia, 30th ed, p739). triamcinolone : A C21-steroid hormone that is 1,4-pregnadiene-3,20-dione carrying four hydroxy substituents at positions 11beta, 16alpha, 17alpha and 21 as well as a fluoro substituent at position 9. Used in the form of its 16,17-acetonide to treat various skin infections.	2.37	2	0	11beta-hydroxy steroid; 16alpha-hydroxy steroid; 17alpha-hydroxy steroid; 20-oxo steroid; 21-hydroxy steroid; 3-oxo-Delta(4) steroid; C21-steroid hormone; fluorinated steroid; glucocorticoid; primary alpha-hydroxy ketone; tertiary alpha-hydroxy ketone	anti-allergic agent; anti-inflammatory drug
oxyphenisatin [no description available]	3.23	1	0	indoles
azetepa [no description available]	2.04	1	0	phosphoramide
fludrocortisone Fludrocortisone: A synthetic mineralocorticoid with anti-inflammatory activity.	3.48	2	0	11beta-hydroxy steroid; 17alpha-hydroxy steroid; 20-oxo steroid; 21-hydroxy steroid; 3-oxo-Delta(4) steroid; C21-steroid; fluorinated steroid; mineralocorticoid	adrenergic agent; anti-inflammatory drug
ursodeoxycholic acid Ursodeoxycholic Acid: An epimer of chenodeoxycholic acid. It is a mammalian bile acid found first in the bear and is apparently either a precursor or a product of chenodeoxycholate. Its administration changes the composition of bile and may dissolve gallstones. It is used as a cholagogue and choleretic.. ursodeoxycholic acid : A bile acid found in the bile of bears (Ursidae) as a conjugate with taurine. Used therapeutically, it prevents the synthesis and absorption of cholesterol and can lead to the dissolution of gallstones.. ursodeoxycholate : A bile acid anion that is the conjugate base of ursodeoxycholic acid, obtained by deprotonation of the carboxy group; major species at pH 7.3.	3.23	1	0	bile acid; C24-steroid; dihydroxy-5beta-cholanic acid	human metabolite; mouse metabolite
pregnanolone Pregnanolone: A pregnane found in the urine of pregnant women and sows. It has anesthetic, hypnotic, and sedative properties.. 3alpha-hydroxy-5beta-pregnan-20-one : The 3alpha-stereoisomer of 3-hydroxy-5beta-pregnan-20-one.	2.04	1	0	3-hydroxy-5beta-pregnan-20-one; 3alpha-hydroxy steroid	human metabolite; intravenous anaesthetic; sedative
du-21220 Ritodrine: An adrenergic beta-2 agonist used to control PREMATURE LABOR.. 4-[2-[[1-hydroxy-1-(4-hydroxyphenyl)propan-2-yl]amino]ethyl]phenol : A secondary amino compound that is 4-(2-amino-1-hydroxypropyl)phenol in which one of the hydrogens attached to the nitrogen is replaced by a 2-(4-hydroxyphenyl)ethyl group.	2.42	2	0	benzyl alcohols; polyphenol; secondary alcohol; secondary amino compound
alkenes [no description available]	2.1	1	0
dexchlorpheniramine dexchlorpheniramine: RN given refers to parent cpd(S)-isomer	3.23	1	0	chlorphenamine
ribostamycin Ribostamycin: A broad-spectrum antimicrobial isolated from Streptomyces ribosifidicus.. ribostamycin : An amino cyclitol glycoside that is 4,6-diaminocyclohexane-1,2,3-triol having a 2,6-diamino-2,6-dideoxy-alpha-D-glucosyl residue attached at position 1 and a beta-D-ribosyl residue attached at position 2. It is an antibiotic produced by Streptomyces ribosidificus (formerly S. thermoflavus).	2.04	1	0	amino cyclitol glycoside; aminoglycoside antibiotic	antibacterial drug; antimicrobial agent; metabolite
pyoluteorin pyoluteorin: from Pseudomonas fluorescens; protects various plants from diseases caused by soilborne pathogenic fungi. pyoluteorin : A member of the class of resorcinols that is resorcinol in which the hydrogen at position 2 is replaced by a 4,5-dichloro-1H-pyrrole-2-carbonyl group. It is a natural product found in Pseudomonas fluorescens which exhibits antibacterial properties and is a strong inducer of caspase-3-dependent apoptosis.	2.21	1	0	aromatic ketone; beta-hydroxy ketone; diol; organochlorine compound; organochlorine pesticide; polyketide; pyrroles; resorcinols	antibacterial agent; antifungal agent; apoptosis inducer; bacterial metabolite; marine metabolite
clometacin clometacin: structure	3.23	1	0	N-acylindole
cefazolin Cefazolin: A semisynthetic cephalosporin analog with broad-spectrum antibiotic action due to inhibition of bacterial cell wall synthesis. It attains high serum levels and is excreted quickly via the urine.. cefazolin : A first-generation cephalosporin compound having [(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]methyl and (1H-tetrazol-1-ylacetyl)amino side-groups at positions 3 and 7 respectively.	9.44	51	4	beta-lactam antibiotic allergen; cephalosporin; tetrazoles; thiadiazoles	antibacterial drug
ripazepam [no description available]	2.04	1	0	benzenes
azides Azides: Organic or inorganic compounds that contain the -N3 group.. azide : Any nitrogen molecular entity containing the group -N3.	1.94	1	0	pseudohalide anion	mitochondrial respiratory-chain inhibitor
amoxicillin Amoxicillin: A broad-spectrum semisynthetic antibiotic similar to AMPICILLIN except that its resistance to gastric acid permits higher serum levels with oral administration.. amoxicillin : A penicillin in which the substituent at position 6 of the penam ring is a 2-amino-2-(4-hydroxyphenyl)acetamido group.	7.23	51	0	penicillin allergen; penicillin	antibacterial drug
timolol (S)-timolol (anhydrous) : The (S)-(-) (more active) enantiomer of timolol. A beta-adrenergic antagonist, both the hemihydrate and the maleate salt are used in the mangement of glaucoma, hypertension, angina pectoris and myocardial infarction, and for the prevention of migraine.	4.24	5	0	timolol	anti-arrhythmia drug; antiglaucoma drug; antihypertensive agent; beta-adrenergic antagonist
indoramin Indoramin: An alpha-1 adrenergic antagonist that is commonly used as an antihypertensive agent.	2.42	2	0	tryptamines
oxcarbazepine Oxcarbazepine: A carbamazepine derivative that acts as a voltage-gated sodium channel blocker. It is used for the treatment of PARTIAL SEIZURES with or without secondary generalization. It is also an inducer of CYTOCHROME P-450 CYP3A4.. oxcarbazepine : A dibenzoazepine derivative, having a carbamoyl group at the ring nitrogen, substituted with an oxo group at C-4 of the azepeine ring which is also hydrogenated at C-4 and C-5. It is a anticholinergic anticonvulsant and mood stabilizing drug, used primarily in the treatment of epilepsy.	3.23	1	0	cyclic ketone; dibenzoazepine	anticonvulsant; drug allergen
carbidopa carbidopa (anhydrous) : 3-(3,4-Dihydroxyphenyl)propanoic acid in which the hydrogens alpha- to the carboxyl group are substituted by hydrazinyl and methyl groups (S-configuration). Carbidopa is a dopa decarboxylase inhibitor, so prevents conversion of levodopa to dopamine. It has no antiparkinson activity by itself, but is used (commonly as its hydrate) in the management of Parkinson's disease to reduce peripheral adverse effects of levodopa.	3.23	1	0	catechols; hydrazines; monocarboxylic acid	antiparkinson drug; dopaminergic agent; EC 4.1.1.28 (aromatic-L-amino-acid decarboxylase) inhibitor
prednimustine Prednimustine: Ester of CHLORAMBUCIL and PREDNISOLONE used as a combination alkylating agent and synthetic steroid to treat various leukemias and other neoplasms. It causes gastrointestinal and bone marrow toxicity.	2.04	1	0	corticosteroid hormone
toloxatone toloxatone: oxazolidinone derivative; psychotropic drug; structure. toloxatone : A racemate consisting of equimolar amounts of (R)- and (S)-toloxatone. It is a reversible monoamine oxidase A inhibitor and antidepressant.. 5-(hydroxymethyl)-3-(3-methylphenyl)-1,3-oxazolidin-2-one : A member of the class of oxazolidinones that is 5-(hydroxymethyl)-1,3-oxazolidin-2-one substituted by a 3-methylphenyl group at position 3.	2.45	2	0	oxazolidinone; primary alcohol; toluenes
moricizine Moricizine: An antiarrhythmia agent used primarily for ventricular rhythm disturbances.. moricizine : A phenothiazine substituted on the nitrogen by a 3-(morpholin-4-yl)propanoyl group, and at position 2 by an (ethoxycarbonyl)amino group.	3.54	2	0	carbamate ester; morpholines; phenothiazines	anti-arrhythmia drug
amygdalin [no description available]	2.04	1	0	cyanogenic glycoside; disaccharide derivative; gentiobioside	plant metabolite
amineptin amineptin: used in treatment of neuroses with psychoasthenic, anxio-phobic & depressive manifestations; synonym S 1694 refers to HCl; structure. amineptine : A carbocyclic fatty acid that is 5-aminoheptanoic acid in which one of the hydrogens attached to the nitrogen is replaced by a 10,11-dihydro-5H-dibenzo[a,d][7]annulen-5-yl group. A tricyclic antidepressant, it was never approved in the US and was withdrawn from the French market in 1999 due to concerns over abuse, dependence and severe acne.	3.58	2	0	amino acid; carbocyclic fatty acid; carbotricyclic compound; secondary amino compound	antidepressant; dopamine uptake inhibitor
zidovudine Zidovudine: A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by an azido group. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. The compound is a potent inhibitor of HIV replication, acting as a chain-terminator of viral DNA during reverse transcription. It improves immunologic function, partially reverses the HIV-induced neurological dysfunction, and improves certain other clinical abnormalities associated with AIDS. Its principal toxic effect is dose-dependent suppression of bone marrow, resulting in anemia and leukopenia.. zidovudine : A pyrimidine 2',3'-dideoxyribonucleoside compound having a 3'-azido substituent and thymine as the nucleobase.	4.24	5	0	azide; pyrimidine 2',3'-dideoxyribonucleoside	antimetabolite; antiviral drug; HIV-1 reverse transcriptase inhibitor
pirprofen pirprofen: anti-inflammatory agent used in therapy of rheumatoid arthritis; prostaglandin synthetase inhibitor; more potent than indomethacin; structure	3.23	1	0	pyrroline
medifoxamine medifoxamine: RN given refers to parent cpd; structure given in first source	2	1	0	aromatic ether
sisomicin Sisomicin: Antibiotic produced by Micromonospora inyoensis. It is closely related to gentamicin C1A, one of the components of the gentamicin complex (GENTAMICINS).	5.42	8	2	amino cyclitol glycoside; aminoglycoside antibiotic; beta-L-arabinoside; monosaccharide derivative
amdinocillin Amdinocillin: An amidinopenicillanic acid derivative with broad spectrum antibacterial action.. mecillinam : A penicillin in which the 6beta substituent is [(azepan-1-yl)methylidene]amino; an extended-spectrum penicillin antibiotic that binds specifically to penicillin binding protein 2 (PBP2), and is only considered to be active against Gram-negative bacteria.	2.71	3	0	penicillin	antibacterial drug; antiinfective agent
tobramycin Tobramycin: An aminoglycoside, broad-spectrum antibiotic produced by Streptomyces tenebrarius. It is effective against gram-negative bacteria, especially the PSEUDOMONAS species. It is a 10% component of the antibiotic complex, NEBRAMYCIN, produced by the same species.. tobramycin : A amino cyclitol glycoside that is kanamycin B lacking the 3-hydroxy substituent from the 2,6-diaminoglucose ring.	4.63	27	0	amino cyclitol glycoside	antibacterial agent; antimicrobial agent; toxin
paclitaxel Taxus: Genus of coniferous yew trees or shrubs, several species of which have medicinal uses. Notable is the Pacific yew, Taxus brevifolia, which is used to make the anti-neoplastic drug taxol (PACLITAXEL).	4.41	6	0	taxane diterpenoid; tetracyclic diterpenoid	antineoplastic agent; human metabolite; metabolite; microtubule-stabilising agent
etoposide [no description available]	3.85	3	0	beta-D-glucoside; furonaphthodioxole; organic heterotetracyclic compound	antineoplastic agent; DNA synthesis inhibitor
dobutamine Dobutamine: A catecholamine derivative with specificity for BETA-1 ADRENERGIC RECEPTORS. It is commonly used as a cardiotonic agent after CARDIAC SURGERY and during DOBUTAMINE STRESS ECHOCARDIOGRAPHY.. dobutamine : A catecholamine that is 4-(3-aminobutyl)phenol in which one of the hydrogens attached to the nitrogen is substituted by a 2-(3,4-dihydroxyphenyl)ethyl group. A beta1-adrenergic receptor agonist that has cardiac stimulant action without evoking vasoconstriction or tachycardia, it is used as the hydrochloride to increase the contractility of the heart in the management of acute heart failure.	3.83	3	0	catecholamine; secondary amine	beta-adrenergic agonist; cardiotonic drug; sympathomimetic agent
ticarcillin Ticarcillin: An antibiotic derived from penicillin similar to CARBENICILLIN in action.. ticarcillin : A penicillin compound having a 6beta-[(2R)-2-carboxy-2-thiophen-3-ylacetyl]amino side-group.	4.1	15	0	penicillin allergen; penicillin	antibacterial drug
trimazosin trimazosin: RN given refers to parent cpd; structure	2.04	1	0	N-arylpiperazine
penbutolol Penbutolol: A nonselective beta-blocker used as an antihypertensive and an antianginal agent.	3.54	2	0	ethanolamines
etidocaine Etidocaine: A local anesthetic with rapid onset and long action, similar to BUPIVACAINE.. etidocaine : An amino acid amide in which 2-[ethyl(propyl)amino]butanoic acid and 2,6-dimethylaniline have combined to form the amide bond. Used as a local anaesthetic (amide caine), it has rapid onset and long action properties, similar to bupivacaine, and is given by injection during surgical procedures and during labour and delivery.	2.04	1	0	amino acid amide	local anaesthetic
ribavirin Rebetron: Rebetron is tradename	3.85	3	0	1-ribosyltriazole; aromatic amide; monocarboxylic acid amide; primary carboxamide	anticoronaviral agent; antiinfective agent; antimetabolite; antiviral agent; EC 2.7.7.49 (RNA-directed DNA polymerase) inhibitor
adinazolam adinazolam: structure in first source. adinazolam : A triazolo[4,3-a][1,4]benzodiazepine having a dimethylaminomethyl group at the 1-position, a phenyl group at the 6-position and a chloro substituent at the 8-position.	2.45	2	0	triazolobenzodiazepine	anticonvulsant; antidepressant; anxiolytic drug; sedative
amikacin Amikacin: A broad-spectrum antibiotic derived from KANAMYCIN. It is reno- and oto-toxic like the other aminoglycoside antibiotics.. amikacin : An amino cyclitol glycoside that is kanamycin A acylated at the N-1 position by a 4-amino-2-hydroxybutyryl group.	7.52	24	1	alpha-D-glucoside; amino cyclitol glycoside; aminoglycoside; carboxamide	antibacterial drug; antimicrobial agent; nephrotoxin
tolamolol [no description available]	2.04	1	0
10-carboxymethyl-9-acridanone 10-carboxymethyl-9-acridanone: RN given refers to parent cpd	3.46	1	1	acridines
cephradine Cephradine: A semi-synthetic cephalosporin antibiotic.. cephradine : A first-generation cephalosporin antibiotic with a methyl substituent at position 3, and a (2R)-2-amino-2-cyclohexa-1,4-dien-1-ylacetamido substituent at position 7, of the cephem skeleton.	4.82	10	0	beta-lactam antibiotic allergen; cephalosporin	antibacterial drug
ticrynafen Ticrynafen: A novel diuretic with uricosuric action. It has been proposed as an antihypertensive agent.. tienilic acid : An aromatic ketone that is 2,3-dichlorophenoxyacetic acid in which the hydrogen at position 4 on the benzene ring is replaced by a thiophenecarbonyl group. A loop diuretic used to treat hypertension, it was withdrawn from the market in 1982 due to links with hepatitis.	3.23	1	0	aromatic ether; aromatic ketone; dichlorobenzene; monocarboxylic acid; thiophenes	antihypertensive agent; hepatotoxic agent; loop diuretic
methyldopa Methyldopa: An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent.. alpha-methyl-L-dopa : A derivative of L-tyrosine having a methyl group at the alpha-position and an additional hydroxy group at the 3-position on the phenyl ring.	4.72	5	0	L-tyrosine derivative; non-proteinogenic L-alpha-amino acid	alpha-adrenergic agonist; antihypertensive agent; hapten; peripheral nervous system drug; sympatholytic agent
tocainide Tocainide: An antiarrhythmic agent which exerts a potential- and frequency-dependent block of SODIUM CHANNELS.. tocainide : A monocarboxylic acid amide in which 2,6-dimethylphenylaniline and isobutyric acid have combined to form the amide bond; used as a local anaesthetic.	2.94	4	0	monocarboxylic acid amide	anti-arrhythmia drug; local anaesthetic; sodium channel blocker
sulbenicillin Sulbenicillin: Semisynthetic penicillin-type antibiotic.. sulbenicillin : A penicillin antibiotic having a 6beta-[phenyl(sulfo)acetamido] side-chain.	2.97	4	0	penicillin
sq-11725 Nadolol: A non-selective beta-adrenergic antagonist with a long half-life, used in cardiovascular disease to treat arrhythmias, angina pectoris, and hypertension. Nadolol is also used for MIGRAINE DISORDERS and for tremor.. nadolol : Nadolol is a diastereoisomeric mixture consisting of equimolar amounts of the four possible 2,3-cis-isomers of 5-[3-(tert-butylamino)-2-hydroxypropoxy]-1,2,3,4-tetrahydronaphthalene-2,3-diol.	2.94	4	0
diltiazem Diltiazem: A benzothiazepine derivative with vasodilating action due to its antagonism of the actions of CALCIUM ion on membrane functions.. diltiazem : A 5-[2-(dimethylamino)ethyl]-2-(4-methoxyphenyl)-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepin-3-yl acetate in which both stereocentres have S configuration. A calcium-channel blocker and vasodilator, it is used as the hydrochloride in the management of angina pectoris and hypertension.	4.06	4	0	5-[2-(dimethylamino)ethyl]-2-(4-methoxyphenyl)-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepin-3-yl acetate	antihypertensive agent; calcium channel blocker; vasodilator agent
nimustine Nimustine: Antineoplastic agent especially effective against malignant brain tumors. The resistance which brain tumor cells acquire to the initial effectiveness of this drug can be partially overcome by the simultaneous use of membrane-modifying agents such as reserpine, calcium antagonists such as nicardipine or verapamil, or the calmodulin inhibitor, trifluoperazine. The drug has also been used in combination with other antineoplastic agents or with radiotherapy for the treatment of various neoplasms.. nimustine : An organochlorine compound that is urea in which the two hydrogens on one of the amino groups are replaced by nitroso and 2-chloroethyl groups and one hydrogen from the other amino group is replaced by a 4-amino-2-methylpyrimidin-5-ylmethyl] group. An antineoplastic agent especially effective against malignant brain tumors.	2.04	1	0	aminopyrimidine; N-nitrosoureas; organochlorine compound	alkylating agent; antineoplastic agent
vecuronium bromide Vecuronium Bromide: Monoquaternary homolog of PANCURONIUM. A non-depolarizing neuromuscular blocking agent with shorter duration of action than pancuronium. Its lack of significant cardiovascular effects and lack of dependence on good kidney function for elimination as well as its short duration of action and easy reversibility provide advantages over, or alternatives to, other established neuromuscular blocking agents.. vecuronium bromide : The organic bromide salt of a 5alpha-androstane compound having 3alpha-acetoxy-, 17beta-acetoxy-, 2beta-piperidinino- and 16beta-N-methylpiperidinium substituents.	2.04	1	0	organic bromide salt; quaternary ammonium salt	muscle relaxant; neuromuscular agent; nicotinic antagonist
vecuronium vecuronium : A 5alpha-androstane compound having 3alpha-acetoxy-, 17beta-acetoxy-, 2beta-piperidino- and 16beta-N-methylpiperidinium substituents.	3.23	1	0	acetate ester; androstane; quaternary ammonium ion	drug allergen; muscle relaxant; neuromuscular agent; nicotinic antagonist
benoxaprofen benoxaprofen: RN given refers to parent cpd; structure. benoxaprofen : A monocarboxylic acid that is propionic acid substituted at position 2 by a 2-(4-chlorophenyl)-1,3-benzoxazol-5-yl group. It was used as a non-steroidal anti-inflammatory drug until 1982 when it was withdrawn from the market due to adverse side-effects including liver necrosis, photosensitivity, and carcinogenicity in animals.	3.23	1	0	1,3-benzoxazoles; monocarboxylic acid; monochlorobenzenes	antipsoriatic; antipyretic; EC 1.13.11.34 (arachidonate 5-lipoxygenase) inhibitor; hepatotoxic agent; nephrotoxin; non-narcotic analgesic; non-steroidal anti-inflammatory drug; protein kinase C agonist
exifone [no description available]	3.23	1	0	benzophenones
mefloquine (-)-(11S,2'R)-erythro-mefloquine : An optically active form of [2,8-bis(trifluoromethyl)quinolin-4-yl]-(2-piperidyl)methanol having (-)-(11S,2'R)-erythro-configuration. An antimalarial agent, used in racemic form, which acts as a blood schizonticide; its mechanism of action is unknown.	3.23	1	0	[2,8-bis(trifluoromethyl)quinolin-4-yl]-(2-piperidyl)methanol	antimalarial
meptazinol Meptazinol: A narcotic antagonist with analgesic properties. It is used for the control of moderate to severe pain.	2.72	3	0	azepanes
butibufen butibufen: RN given refers to parent cpd	2.04	1	0	monoterpenoid
nitazoxanide nitazoxanide: a 5-nitrothiazolyl derivative used for a broad range of intestinal parasitic infections including CRYPTOSPORIDIUM and GIARDIA; it is a redox-active nitrothiazolyl-salicylamide prodrug	3.23	1	0	benzamides; carboxylic ester
sufentanil Sufentanil: An opioid analgesic that is used as an adjunct in anesthesia, in balanced anesthesia, and as a primary anesthetic agent.. sufentanil : An anilide resulting from the formal condensation of the aryl amino group of 4-(methoxymethyl)-N-phenyl-1-[2-(2-thienyl)ethyl]piperidin-4-amine with propanoic acid.	3.85	3	0	anilide; ether; piperidines; thiophenes	anaesthesia adjuvant; intravenous anaesthetic; mu-opioid receptor agonist; opioid analgesic
acarbose [no description available]	3.23	1	0	tetrasaccharide derivative	EC 3.2.1.1 (alpha-amylase) inhibitor; EC 3.2.1.20 (alpha-glucosidase) inhibitor; geroprotector; hypoglycemic agent
torsemide Torsemide: A pyridine and sulfonamide derivative that acts as a sodium-potassium chloride symporter inhibitor (loop diuretic). It is used for the treatment of EDEMA associated with CONGESTIVE HEART FAILURE; CHRONIC RENAL INSUFFICIENCY; and LIVER DISEASES. It is also used for the management of HYPERTENSION.. torasemide : An N-sulfonylurea obtained by formal condensation of [(3-methylphenyl)amino]pyridine-3-sulfonic acid with the free amino group of N-isopropylurea. It is a potent loop diuretic used for the treatment of hypertension and edema in patients with congestive heart failure.	3.85	3	0	aminopyridine; N-sulfonylurea; secondary amino compound	antihypertensive agent; loop diuretic
medroxalol medroxalol: RN given refers to parent cpd without isomeric designation	2.04	1	0	salicylamides
epirubicin Epirubicin: An anthracycline which is the 4'-epi-isomer of doxorubicin. The compound exerts its antitumor effects by interference with the synthesis and function of DNA.	3.85	3	0	aminoglycoside; anthracycline antibiotic; anthracycline; deoxy hexoside; monosaccharide derivative; p-quinones; primary alpha-hydroxy ketone; tertiary alpha-hydroxy ketone	antimicrobial agent; antineoplastic agent; EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor
spiromustine [no description available]	2.04	1	0
cefmetazole Cefmetazole: A semisynthetic cephamycin antibiotic with a broad spectrum of activity against both gram-positive and gram-negative microorganisms. It has a high rate of efficacy in many types of infection and to date no severe side effects have been noted.. cefmetazole : A second-generation cephalosporin antibiotic having N(1)-methyltetrazol-5-ylthiomethyl, {[(cyanomethyl)sulfanyl]acetyl}amino and methoxy side-groups at positions 3, 7beta and 7alpha respectively of the parent cephem bicyclic structure.	3.54	8	0	cephalosporin	antibacterial drug
prenalterol Prenalterol: A partial adrenergic agonist with functional beta 1-receptor specificity and inotropic effect. It is effective in the treatment of acute CARDIAC FAILURE, postmyocardial infarction low-output syndrome, SHOCK, and reducing ORTHOSTATIC HYPOTENSION in the SHY-RAGER SYNDROME.	2	1	0	aromatic ether
closantel closantel: structure. N-{5-chloro-4-[(4-chlorophenyl)(cyano)methyl]-2-methylphenyl}-2-hydroxy-3,5-diiodobenzamide : An aromatic amide resulting from the formal condensation of the carboxy group of 3,5-diiodosalicylic acid with the amino group of aniline substituted at positions 2, 4, and 5 by methyl, (4-chlorophenyl)(cyano)methyl, and methyl groups respectively.. closantel : A racemate comprising equimolar amounts of (R)- and (S)-clostanel. An anthelmintic, it is used (as the dihydrate of the sodium salt) in veterinary medicine for the treatment of fluke and nematode infections.	1.99	1	0	aromatic amide; monocarboxylic acid amide; monochlorobenzenes; nitrile; organoiodine compound; phenols
diaziquone diaziquone: RN given refers to parent cpd. diaziquone : A 1,4-benzoquinone that is substituted at positions 2 and 5 have been replaced by aziridin-1-yl groups and at positions 3 and 6 by (ethoxycarbonyl)amino groups.	2.04	1	0	1,4-benzoquinones; aziridines; carbamate ester; enamine	alkylating agent; antineoplastic agent
lorcainide [no description available]	2.72	3	0	acetamides
idarubicin Idarubicin: An orally administered anthracycline antineoplastic. The compound has shown activity against BREAST NEOPLASMS; LYMPHOMA; and LEUKEMIA.	4.07	4	0	anthracycline antibiotic; deoxy hexoside; monosaccharide derivative
propiconazole Orbit: Bony cavity that holds the eyeball and its associated tissues and appendages.	3.46	2	0	conazole fungicide; cyclic ketal; dichlorobenzene; triazole fungicide; triazoles	antifungal agrochemical; EC 1.14.13.70 (sterol 14alpha-demethylase) inhibitor; environmental contaminant; xenobiotic
ceforanide ceforanide: RN given refers to (6R-(trans))-isomer. ceforanide : A second-generation cephalosporin antibiotic with {[1-(carboxymethyl)-1H-tetrazol-5-yl]sulfanyl}methyl and 2-(aminomethyl)phenylacetamido groups at positions 3 and 7, respectively, of the cephem skeleton. It is effective against many coliforms, including Escherichia coli, Klebsiella, Enterobacter and Proteus, and most strains of Salmonella, Shigella, Hemophilus, Citrobacter and Arizona species.	2.04	1	0	cephalosporin	antibacterial drug
cefonicid Cefonicid: A second-generation cephalosporin administered intravenously or intramuscularly. Its bactericidal action results from inhibition of cell wall synthesis. It is used for urinary tract infections, lower respiratory tract infections, and soft tissue and bone infections.. cefonicid : A cephalosporin bearing {[1-(sulfomethyl)-1H-tetrazol-5-yl]sulfanyl}methyl and (R)-2-hydroxy-2-phenylacetamido groups at positions 3 and 7, respectively, of the cephem skeleton.	2.04	1	0	cephalosporin	antibacterial drug
piperacillin Piperacillin: Semisynthetic, broad-spectrum, AMPICILLIN derived ureidopenicillin antibiotic proposed for PSEUDOMONAS infections. It is also used in combination with other antibiotics.. piperacillin : A penicillin in which the substituent at position 6 of the penam ring is a 2-[(4-ethyl-2,3-dioxopiperazin-1-yl)carboxamido]-2-phenylacetamido group.	6	34	0	penicillin allergen; penicillin	antibacterial drug
cefotiam Cefotiam: One of the CEPHALOSPORINS that has a broad spectrum of activity against both gram-positive and gram-negative microorganisms.. cefotiam : A cephalosporin with ({1-[2-(dimethylamino)ethyl]-1H-tetrazol-5-yl}sulfanyl)methyl and (2-amino-1,3-thiazol-4-yl)acetamido substituents at positions 3 and 7, respectively, of the cephem skeleton. A third generation beta-lactam cephalosporin antibiotic, it is active against a broad spectrum of both Gram positive and Gram negative bacteria.	7.68	3	0	beta-lactam antibiotic allergen; cephalosporin; semisynthetic derivative	antibacterial drug
paroxetine Paroxetine: A serotonin uptake inhibitor that is effective in the treatment of depression.. paroxetine : A benzodioxole that consists of piperidine bearing 1,3-benzodioxol-5-yloxy)methyl and 4-fluorophenyl substituents at positions 3 and 4 respectively; the (3S,4R)-diastereomer. Highly potent and selective 5-HT uptake inhibitor that binds with high affinity to the serotonin transporter (Ki = 0.05 nM). Ki values are 1.1, 350 and 1100 nM for inhibition of [3H]-5-HT, [3H]-l-NA and [3H]-DA uptake respectively. Displays minimal affinity for alpha1-, alpha2- or beta-adrenoceptors, 5-HT2A, 5-HT1A, D2 or H1 receptors at concentrations below 1000 nM, however displays weak affinity for muscarinic ACh receptors (Ki = 42 nM). Antidepressant and anxiolytic in vivo.	4.06	4	0	aromatic ether; benzodioxoles; organofluorine compound; piperidines	antidepressant; anxiolytic drug; hepatotoxic agent; P450 inhibitor; serotonin uptake inhibitor
triciribine phosphate [no description available]	2.04	1	0
captopril Captopril: A potent and specific inhibitor of PEPTIDYL-DIPEPTIDASE A. It blocks the conversion of ANGIOTENSIN I to ANGIOTENSIN II, a vasoconstrictor and important regulator of arterial blood pressure. Captopril acts to suppress the RENIN-ANGIOTENSIN SYSTEM and inhibits pressure responses to exogenous angiotensin.. captopril : A L-proline derivative in which L-proline is substituted on nitrogen with a (2S)-2-methyl-3-sulfanylpropanoyl group. It is used as an anti-hypertensive ACE inhibitor drug.	4.39	6	0	alkanethiol; L-proline derivative; N-acylpyrrolidine; pyrrolidinemonocarboxylic acid	antihypertensive agent; EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor
cefoperazone Cefoperazone: Semisynthetic broad-spectrum cephalosporin with a tetrazolyl moiety that is resistant to beta-lactamase. It may be used to treat Pseudomonas infections.. cefoperazone : A semi-synthetic parenteral cephalosporin with a tetrazolyl moiety that confers beta-lactamase resistance.	9.91	11	0	cephalosporin	antibacterial drug
atracurium Atracurium: A non-depolarizing neuromuscular blocking agent with short duration of action. Its lack of significant cardiovascular effects and its lack of dependence on good kidney function for elimination provide clinical advantage over alternate non-depolarizing neuromuscular blocking agents.. atracurium : A diester compound consisting of pentane-1,5-diol with both hydroxyls bearing 3-[1-(3,4-dimethoxybenzyl)-6,7-dimethoxy-2-methyl-3,4-dihydroisoquinolinium-2(1H)-yl]propanoyl groups.	3.58	2	0	diester; quaternary ammonium ion	muscle relaxant; nicotinic antagonist
moxalactam Moxalactam: Broad- spectrum beta-lactam antibiotic similar in structure to the CEPHALOSPORINS except for the substitution of an oxaazabicyclo moiety for the thiaazabicyclo moiety of certain CEPHALOSPORINS. It has been proposed especially for the meningitides because it passes the blood-brain barrier and for anaerobic infections.. moxalactam : A broad-spectrum oxacephem antibiotic in which the oxazine ring is substituted with a tetrazolylthiomethyl group and the azetidinone ring carries methoxy and 2-carboxy-2-(4-hydroxyphenyl)acetamido substituents.	8.95	13	0	cephalosporin; oxacephem	antibacterial drug
endralazine BQ 22-708: RN given refers to parent cpd	2.04	1	0	benzamides
bw-755c 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine: A dual inhibitor of both cyclooxygenase and lipoxygenase pathways. It exerts an anti-inflammatory effect by inhibiting the formation of prostaglandins and leukotrienes. The drug also enhances pulmonary hypoxic vasoconstriction and has a protective effect after myocardial ischemia.	2.04	1	0
pergolide Pergolide: A long-acting dopamine agonist which has been used to treat PARKINSON DISEASE and HYPERPROLACTINEMIA but withdrawn from some markets due to potential for HEART VALVE DISEASES.. pergolide : A diamine that is ergoline in which the beta-hydrogen at position 8 is replaced by a (methylthio)methyl group and the hydrogen attached to the piperidine nitrogen (position 6) is replaced by a propyl group. A dopamine D2 receptor agonist which also has D1 and D2 agonist properties, it is used as the mesylate salt in the management of Parkinson's disease, although it was withdrawn from the U.S. and Canadian markets in 2007 due to an increased risk of cardiac valve dysfunction.	3.23	1	0	diamine; methyl sulfide; organic heterotetracyclic compound	antiparkinson drug; dopamine agonist
cefadroxil anhydrous Cefadroxil: Long-acting, broad-spectrum, water-soluble, CEPHALEXIN derivative.. cefadroxil : A cephalosporin bearing methyl and (2R)-2-amino-2-(4-hydroxyphenyl)acetamido groups at positions 3 and 7, respectively, of the cephem skeleton.	4.54	7	0	cephalosporin	antibacterial drug
encainide Encainide: One of the ANTI-ARRHYTHMIA AGENTS, it blocks VOLTAGE-GATED SODIUM CHANNELS and slows conduction within the His-Purkinje system and MYOCARDIUM.. encainide : 4-Methoxy-N-phenylbenzamide in which the hydrogen at the 2 position of the phenyl group is substituted by a 2-(1-methylpiperidin-2-yl)ethyl group. A class Ic antiarrhythmic, the hydrochloride was used for the treatment of severe or life-threatening ventricular arrhythmias, but it was associated with increased death rates in patients who had asymptomatic heart rhythm abnormalities after a recent heart attack and was withdrawn from the market.	2.72	3	0	benzamides; piperidines	anti-arrhythmia drug; sodium channel blocker
fialuridine [no description available]	3.23	1	0
cefaclor anhydrous Cefaclor: Semisynthetic, broad-spectrum antibiotic derivative of CEPHALEXIN.. cefaclor : A cephalosporin bearing chloro and (R)-2-amino-2-phenylacetamido groups at positions 3 and 7, respectively, of the cephem skeleton.	4.92	11	0	cephalosporin	antibacterial drug; drug allergen
pefloxacin Pefloxacin: A synthetic broad-spectrum fluoroquinolone antibacterial agent active against most gram-negative and gram-positive bacteria.. pefloxacin : A quinolone that is 4-oxo-1,4-dihydroquinoline which is substituted at positions 1, 3, 6 and 7 by ethyl, carboxy, fluorine, and 4-methylpiperazin-1-yl groups, respectively.	11.54	8	2	fluoroquinolone antibiotic; monocarboxylic acid; N-alkylpiperazine; N-arylpiperazine; quinolone antibiotic; quinolone	antibacterial drug; antiinfective agent; DNA synthesis inhibitor
alfentanil Alfentanil: A short-acting opioid anesthetic and analgesic derivative of FENTANYL. It produces an early peak analgesic effect and fast recovery of consciousness. Alfentanil is effective as an anesthetic during surgery, for supplementation of analgesia during surgical procedures, and as an analgesic for critically ill patients.. alfentanil : A member of the class of piperidines that is piperidine having a 2-(4-ethyl-5-oxo-4,5-dihydro-1H-tetrazol-1-yl)ethyl group at the 1-position as well as N-phenylpropanamido- and methoxymethyl groups at the 4-position.	4.07	4	0	monocarboxylic acid amide; piperidines	central nervous system depressant; intravenous anaesthetic; mu-opioid receptor agonist; opioid analgesic; peripheral nervous system drug
miglustat miglustat: a glucosylceramide synthase inhibitor. miglustat : A hydroxypiperidine that is deoxynojirimycin in which the amino hydrogen is replaced by a butyl group.	3.23	1	0	piperidines; tertiary amino compound	anti-HIV agent; EC 2.4.1.80 (ceramide glucosyltransferase) inhibitor
haloperidol decanoate [no description available]	3.23	1	0	organic molecular entity
cefotetan Cefotetan: A semisynthetic cephamycin antibiotic that is administered intravenously or intramuscularly. The drug is highly resistant to a broad spectrum of beta-lactamases and is active against a wide range of both aerobic and anaerobic gram-positive and gram-negative microorganisms.. cefotetan : A semi-synthetic second-generation cephamycin antibiotic with [(1-methyl-1H-tetrazol-5-yl)sulfanyl]methyl, methoxy and {[4-(2-amino-1-carboxy-2-oxoethylidene)-1,3-dithietan-2-yl]carbonyl}amino groups at the 3, 7alpha, and 7beta positions, respectively, of the cephem skeleton. It is resistant to a wide range of beta-lactamases and is active against a broad spectrum of aerobic and anaerobic Gram-positive and Gram-negative microorganisms.	3.8	3	0
recainam recainam: structure given in first source	2.45	2	0
lovastatin Lovastatin: A fungal metabolite isolated from cultures of Aspergillus terreus. The compound is a potent anticholesteremic agent. It inhibits 3-hydroxy-3-methylglutaryl coenzyme A reductase (HYDROXYMETHYLGLUTARYL COA REDUCTASES), which is the rate-limiting enzyme in cholesterol biosynthesis. It also stimulates the production of low-density lipoprotein receptors in the liver.. lovastatin : A fatty acid ester that is mevastatin carrying an additional methyl group on the carbobicyclic skeleton. It is used in as an anticholesteremic drug and has been found in fungal species such as Aspergillus terreus and Pleurotus ostreatus (oyster mushroom).	4.06	4	0	delta-lactone; fatty acid ester; hexahydronaphthalenes; polyketide; statin (naturally occurring)	anticholesteremic drug; antineoplastic agent; Aspergillus metabolite; prodrug
flupirtine flupirtine: RN given refers to parent cpd without isomeric designation	2.45	2	0	aminopyridine
tolrestat tolrestat: RN & structure given in first source	3.23	1	0	naphthalenes	EC 1.1.1.21 (aldehyde reductase) inhibitor
enoximone Enoximone: A selective phosphodiesterase inhibitor with vasodilating and positive inotropic activity that does not cause changes in myocardial oxygen consumption. It is used in patients with CONGESTIVE HEART FAILURE.	2.72	3	0	aromatic ketone
piritrexim piritrexim: RN given refers to parent cpd; structure given in first source	2.04	1	0
simvastatin Simvastatin: A derivative of LOVASTATIN and potent competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase (HYDROXYMETHYLGLUTARYL COA REDUCTASES), which is the rate-limiting enzyme in cholesterol biosynthesis. It may also interfere with steroid hormone production. Due to the induction of hepatic LDL RECEPTORS, it increases breakdown of LDL CHOLESTEROL.. simvastatin : A member of the class of hexahydronaphthalenes that is lovastatin in which the 2-methylbutyrate ester moiety has been replaced by a 2,2-dimethylbutyrate ester group. It is used as a cholesterol-lowering and anti-cardiovascular disease drug.	3.54	2	0	delta-lactone; fatty acid ester; hexahydronaphthalenes; statin (semi-synthetic)	EC 1.1.1.34/EC 1.1.1.88 (hydroxymethylglutaryl-CoA reductase) inhibitor; EC 3.4.24.83 (anthrax lethal factor endopeptidase) inhibitor; ferroptosis inducer; geroprotector; prodrug
idazoxan Idazoxan: A benzodioxane-linked imidazole that has alpha-2 adrenoceptor antagonist activity.. idazoxan : A benzodioxine that is 2,3-dihydro-1,4-benzodioxine in which one of the hydrogens at position 2 has been replaced by a 4,5-dihydro-1H-imidazol-2-yl group.	2.04	1	0	benzodioxine; imidazolines	alpha-adrenergic antagonist
remoxipride Remoxipride: An antipsychotic agent that is specific for dopamine D2 receptors. It has been shown to be effective in the treatment of schizophrenia.	2.45	2	0	dimethoxybenzene
balsalazide balsalazide: a mesalamine 5-aminosalicylate prodrug; 99% of ingested drug remains intact through the stomach and is delivered to and activated in the colon; used for inflammatory bowel disease, ulcerative colitis and radiation-induced proctosigmoiditis but avoided in patients with known hypersensitivity reaction to salicylates or mesalamine; structure in first source. balsalazide : A monohydroxybenzoic acid consisting of 5-aminosalicylic acid (mesalazine) linked to 4-aminobenzoyl-beta-alanine via an azo bond.	3.23	1	0
pravastatin Pravastatin: An antilipemic fungal metabolite isolated from cultures of Nocardia autotrophica. It acts as a competitive inhibitor of HMG CoA reductase (HYDROXYMETHYLGLUTARYL COA REDUCTASES).. pravastatin : A carboxylic ester resulting from the formal condensation of (S)-2-methylbutyric acid with the hydroxy group adjacent to the ring junction of (3R,5R)-7-[(1S,2S,6S,8S,8aR)-6,8-dihydroxy-2-methyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]-3,5-dihydroxyheptanoic acid. Derived from microbial transformation of mevastatin, pravastatin is a reversible inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA). The sodium salt is used for lowering cholesterol and preventing cardiovascular disease. It is one of the lower potency statins, but has the advantage of fewer side effects compared with lovastatin and simvastatin.	3.85	3	0	3-hydroxy carboxylic acid; carbobicyclic compound; carboxylic ester; hydroxy monocarboxylic acid; secondary alcohol; statin (semi-synthetic)	anticholesteremic drug; environmental contaminant; metabolite; xenobiotic
cabergoline Cabergoline: An ergoline derivative and dopamine D2-agonist that inhibits PROLACTIN secretion. It is used in the management of HYPERPROLACTINEMIA, and to suppress lactation following childbirth for medical reasons. Cabergoline is also used in the management of PARKINSON DISEASE.. cabergoline : An N-acylurea that is (8R)-ergoline-8-carboxamide in which the hydrogen attached to the piperidine nitrogen (position 6) is substituted by an allyl group and the hydrogens attached to the carboxamide nitrogen are substituted by a 3-(dimethylamino)propyl group and an N-ethylcarbamoyl group. A dopamine D2 receptor agonist, cabergoline is used in the management of Parkinson's disease and of disorders associated with hyperprolactinaemia.	3.23	1	0	N-acylurea	antineoplastic agent; antiparkinson drug; dopamine agonist
caracemide [no description available]	2.04	1	0
bambuterol bambuterol: selective inhibitor of butyrylcholinesterase & acetylcholinesterase. bambuterol : A carbamate ester that is terbutaline in which both of the phenolic hydroxy groups have been protected as the corresponding N,N-dimethylcarbamates. A long acting beta-adrenoceptor agonist used in the treatment of asthma, it is a prodrug for terbutaline.	2.44	2	0	carbamate ester; phenylethanolamines	anti-asthmatic drug; beta-adrenergic agonist; bronchodilator agent; EC 3.1.1.7 (acetylcholinesterase) inhibitor; prodrug; sympathomimetic agent; tocolytic agent
atomoxetine atomoxetine : A secondary amino compound having methyl and 3-(2-methylphenoxy)-3-phenylpropan-1-yl substituents.	3.85	3	0	aromatic ether; secondary amino compound; toluenes	adrenergic uptake inhibitor; antidepressant; environmental contaminant; xenobiotic
quinapril Quinapril: A tetrahydroisoquinoline derivative and ANGIOTENSIN CONVERTING ENZYME inhibitor that is used in the treatment of HYPERTENSION and HEART FAILURE.. quinapril : A member of the class of isoquinolines that is (3S)-2-L-alanyl-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid in which the alpha-amino group of the alanyl residue has been substituted by a 1-ethoxycarbonyl-4-phenylbutan-2-yl group (the all-S isomer). A prodrug for quinaprilat (by hydrolysis of the ethyl ester to the corresponding carboxylic acid), it is used as an angiotensin-converting enzyme inhibitor (ACE inhibitor) used (generally as the hydrochloride salt) for the treatment of hypertension and congestive heart failure.	3.58	2	0	dicarboxylic acid monoester; ethyl ester; isoquinolines; tertiary carboxamide	antihypertensive agent; EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor; prodrug
alpidem [no description available]	3.23	1	0	imidazoles
mifepristone Mifepristone: A progestational and glucocorticoid hormone antagonist. Its inhibition of progesterone induces bleeding during the luteal phase and in early pregnancy by releasing endogenous prostaglandins from the endometrium or decidua. As a glucocorticoid receptor antagonist, the drug has been used to treat hypercortisolism in patients with nonpituitary CUSHING SYNDROME.	3.23	1	0	3-oxo-Delta(4) steroid; acetylenic compound; tertiary amino compound	abortifacient; contraceptive drug; hormone antagonist; synthetic oral contraceptive
itraconazole Itraconazole: A triazole antifungal agent that inhibits cytochrome P-450-dependent enzymes required for ERGOSTEROL synthesis.. itraconazole : An N-arylpiperazine that is cis-ketoconazole in which the imidazol-1-yl group is replaced by a 1,2,4-triazol-1-yl group and in which the actyl group attached to the piperazine moiety is replaced by a p-[(+-)1-sec-butyl-5-oxo-1,5-dihydro-4H-1,2,4-triazol-4-yl]phenyl group. A potent P-glycoprotein and CYP3A4 inhibitor, it is used as an antifungal drug for the treatment of various fungal infections, including aspergillosis, blastomycosis, candidiasis, chromoblastomycosis, coccidioidomycosis, cryptococcosis, histoplasmosis, and sporotrichosis.	1.98	1	0	aromatic ether; conazole antifungal drug; cyclic ketal; dichlorobenzene; dioxolane; N-arylpiperazine; triazole antifungal drug; triazoles	EC 3.6.3.44 (xenobiotic-transporting ATPase) inhibitor; Hedgehog signaling pathway inhibitor; P450 inhibitor
trospectomycin trospectomycin: active against Neisseria gonorrhoeae; RN refers to 2R-(2alpha,4abeta,5abeta,6beta,7beta,8beta,9beta,9alpha,9aalpha,10abeta)-(9CI)-isomer	2.04	1	0	dioxanes
cilazapril, anhydrous Cilazapril: One of the ANGIOTENSIN-CONVERTING ENZYME INHIBITORS (ACE inhibitors) used for hypertension. It is a prodrug that is hydrolyzed after absorption to its main metabolite cilazaprilat.. cilazapril : A pyridazinodiazepine resulting from the formal condensation of the carboxy group of cilazaprilat with ethanol. It is a drug used in the treatment of hypertension and heart failure.	2.04	1	0	dicarboxylic acid monoester; ethyl ester; pyridazinodiazepine	antihypertensive agent; EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor; prodrug
fosphenytoin fosphenytoin: structure given in first & second source	3.23	1	0	imidazolidine-2,4-dione
ranolazine Ranolazine: An acetanilide and piperazine derivative that functions as a SODIUM CHANNEL BLOCKER and prevents the release of enzymes during MYOCARDIAL ISCHEMIA. It is used in the treatment of ANGINA PECTORIS.. N-(2,6-dimethylphenyl)-2-{4-[2-hydroxy-3-(2-methoxyphenoxy)propyl]piperazin-1-yl}acetamide : An aromatic amide obtained by formal condensation of the carboxy group of 2-{4-[2-hydroxy-3-(2-methoxyphenoxy)propyl]piperazin-1-yl}acetic acid with the amino group of 2,6-dimethylaniline.. ranolazine : A racemate comprising equal amounts of (R)- and (S)-ranolazine. Used for treatment of chronic angina.	3.23	1	0	aromatic amide; monocarboxylic acid amide; monomethoxybenzene; N-alkylpiperazine; secondary alcohol
finasteride Finasteride: An orally active 3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE inhibitor. It is used as a surgical alternative for treatment of benign PROSTATIC HYPERPLASIA.. finasteride : An aza-steroid that is a synthetic drug for the treatment of benign prostatic hyperplasia.	3.85	3	0	3-oxo steroid; aza-steroid; delta-lactam	androgen antagonist; antihyperplasia drug; EC 1.3.1.22 [3-oxo-5alpha-steroid 4-dehydrogenase (NADP(+))] inhibitor
sematilide sematilide: RN refers to HCl; structure given in first source	2.45	2	0
esmolol methyl 3-{4-[2-hydroxy-3-(propan-2-ylamino)propoxy]phenyl}propanoate : A methyl ester that is methyl 3-(4-hydroxyphenyl)propanoate in which the hydrogen attached to the phenolic hydroxy group is substituted by a 2-hydroxy-3-(isopropylamino)propyl group.. esmolol : A racemate comprising equimolar amounts of (R)- and (S)-esmolol. A cardioselective and short-acting beta1 receptor blocker with rapid onset but lacking intrinsic sympathomimetic and membrane-stabilising properties, it is used as the hydrochloride salt in the management of supraventricular arrhythmias, and for the control of hypertension and tachycardia during surgery. While the S enantiomer possesses all of the heart rate control, both enantiomers contribute to lowering blood pressure.	3.58	2	0	aromatic ether; ethanolamines; methyl ester; secondary alcohol; secondary amino compound
temafloxacin temafloxacin: structure given in first source. temafloxacin : A racemate comprising equimolar amounts of (R)- and (S)-temafloxacin. Both enantiomers both exhibit similar pharmacological profiles. Temafloxacin was briefly used (either as the free base or as the hydrochloride salt) as an antibacterial drug but was withdrawn worldwide in 1992 following reports of serious side effects, including severe hypoglycaemia, haemolytic anaemia, liver and kidney dysfunction, anaphylaxis, and death.. 1-(2,4-difluorophenyl)-6-fluoro-7-(3-methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid : A quinolone that is 4-oxo-1,4-dihydroquinoline-3-carboxylic acid which is substituted at positions 1, 6, and 7 by 2,4-difluorophenyl, fluorine, and 3-methylpiperazin-1-yl groups, respectively.	1.97	1	0	amino acid; monocarboxylic acid; N-arylpiperazine; organofluorine compound; quinolone antibiotic; quinolone; secondary amino compound; tertiary amino compound
clinafloxacin clinafloxacin: structure given in first source; RN given is for monoHCl	2.45	2	0	quinolines
adefovir adefovir: inhibitor of African swine fever virus. adefovir(1-) : A organophosphonate oxoanion obtained by removal of a proton from the phosphonate group of adefovir, a nucleoside reverse transcriptase inhibitor. It is the major microspecies at pH 7.3 (according to Marvin v 6.2.0.).. adefovir : A member of the class of phosphonic acids that is methylphosphonic acid in which one of the methyl hydrogens has been replaced by a 2-(6-amino-9H-purin-9-yl)ethoxy group. An inhibitor of HIV-1 reverse transcriptase, the bis(t-butoxycarbonyloxymethyl) ester (dipivoxil ester) prodrug is used to treat chronic hepatitis B viral infection.	3.85	3	0	6-aminopurines; ether; phosphonic acids	antiviral drug; DNA synthesis inhibitor; drug metabolite; HIV-1 reverse transcriptase inhibitor; nephrotoxic agent
loxiglumide loxiglumide: cholecystokinin receptor antagonist; RN refers to (+-)-isomer; structure in first source	2.04	1	0	organic molecular entity
aromasil [no description available]	3.23	1	0	17-oxo steroid; 3-oxo-Delta(1),Delta(4)-steroid	antineoplastic agent; EC 1.14.14.14 (aromatase) inhibitor; environmental contaminant; xenobiotic
sparfloxacin [no description available]	8.26	6	0	fluoroquinolone antibiotic; N-arylpiperazine; quinolinemonocarboxylic acid; quinolone antibiotic; quinolone
zileuton [no description available]	3.23	1	0	1-benzothiophenes; ureas	anti-asthmatic drug; EC 1.13.11.34 (arachidonate 5-lipoxygenase) inhibitor; ferroptosis inhibitor; leukotriene antagonist; non-steroidal anti-inflammatory drug
clopidogrel Clopidogrel: A ticlopidine analog and platelet purinergic P2Y receptor antagonist that inhibits adenosine diphosphate-mediated PLATELET AGGREGATION. It is used to prevent THROMBOEMBOLISM in patients with ARTERIAL OCCLUSIVE DISEASES; MYOCARDIAL INFARCTION; STROKE; or ATRIAL FIBRILLATION.. clopidogrel : A thienopyridine that is 4,5,6,7-tetrahydrothieno[3,2-c]pyridine in which the hydrogen attached to the nitrogen is replaced by an o-chlorobenzyl group, the methylene hydrogen of which is replaced by a methoxycarbonyl group (the S enantiomer). A P2Y12 receptor antagonist, it is used to inhibit blood clots and prevent heart attacks.	3.23	1	0	methyl ester; monochlorobenzenes; thienopyridine	anticoagulant; P2Y12 receptor antagonist; platelet aggregation inhibitor
cidofovir anhydrous Cidofovir: An acyclic nucleoside phosphonate that acts as a competitive inhibitor of viral DNA polymerases. It is used in the treatment of RETINITIS caused by CYTOMEGALOVIRUS INFECTIONS and may also be useful for treating HERPESVIRUS INFECTIONS.. cidofovir anhydrous : Cytosine substituted at the 1 position by a 3-hydroxy-2-(phosphonomethoxy)propyl group (S configuration). A nucleoside analogue, it is an injectable antiviral used for the treatment of cytomegalovirus (CMV) retinitis in AIDS patients.	3.85	3	0	phosphonic acids; pyrimidone	anti-HIV agent; antineoplastic agent; antiviral drug; photosensitizing agent
tiagabine Tiagabine: A nipecotic acid derivative that acts as a GABA uptake inhibitor and anticonvulsant agent. It is used in the treatment of EPILEPSY, for refractory PARTIAL SEIZURES.. tiagabine : A piperidinemonocarboxylic acid that is (R)-nipecotic acid in which the hydrogen attached to the nitrogen has been replaced by a 1,1-bis(3-methyl-2-thienyl)but-1-en-4-yl group. A GABA reuptake inhibitor, it is used (generally as the hydrochloride salt) for the treatment of epilepsy.	3.85	3	0	beta-amino acid; piperidinemonocarboxylic acid; tertiary amino compound; thiophenes	anticonvulsant; GABA reuptake inhibitor
mibefradil Mibefradil: A benzimidazoyl-substituted tetraline that selectively binds and inhibits CALCIUM CHANNELS, T-TYPE.	2.42	2	0	tetralins	T-type calcium channel blocker
topotecan Topotecan: An antineoplastic agent used to treat ovarian cancer. It works by inhibiting DNA TOPOISOMERASES, TYPE I.. topotecan : A pyranoindolizinoquinoline used as an antineoplastic agent. It is a derivative of camptothecin and works by binding to the topoisomerase I-DNA complex and preventing religation of these 328 single strand breaks.	3.85	3	0	pyranoindolizinoquinoline	antineoplastic agent; EC 5.99.1.2 (DNA topoisomerase) inhibitor
bromfenac bromfenac: bromfenac sodium is the active cpd; structure in first source. bromfenac : Amfenac in which the the hydrogen at the 4 position of the benzoyl group is substituted by bromine. It is used for the management of ocular pain and treatment of postoperative inflammation in patients who have undergone cataract extraction. It was withdrawn from the US market in 1998, following concerns over off-label abuse and hepatic failure.	4.06	4	0	aromatic amino acid; benzophenones; organobromine compound; substituted aniline	non-narcotic analgesic; non-steroidal anti-inflammatory drug
gemcitabine gemcitabine : A 2'-deoxycytidine having geminal fluoro substituents in the 2'-position. An inhibitor of ribonucleotide reductase, gemcitabine is used in the treatment of various carcinomas, particularly non-small cell lung cancer, pancreatic cancer, bladder cancer and breast cancer.	3.85	3	0	organofluorine compound; pyrimidine 2'-deoxyribonucleoside	antimetabolite; antineoplastic agent; antiviral drug; DNA synthesis inhibitor; EC 1.17.4.1 (ribonucleoside-diphosphate reductase) inhibitor; environmental contaminant; immunosuppressive agent; photosensitizing agent; prodrug; radiosensitizing agent; xenobiotic
ibutilide ibutilide: RN & structure in first source; RN refers to the fumarate salt	3.85	3	0	benzenes; organic amino compound
aripiprazole Aripiprazole: A piperazine and quinolone derivative that is used primarily as an antipsychotic agent. It is a partial agonist of SEROTONIN RECEPTOR, 5-HT1A and DOPAMINE D2 RECEPTORS, where it also functions as a post-synaptic antagonist, and an antagonist of SEROTONIN RECEPTOR, 5-HT2A. It is used for the treatment of SCHIZOPHRENIA and BIPOLAR DISORDER, and as an adjunct therapy for the treatment of depression.. aripiprazole : An N-arylpiperazine that is piperazine substituted by a 4-[(2-oxo-1,2,3,4-tetrahydroquinolin-7-yl)oxy]butyl group at position 1 and by a 2,3-dichlorophenyl group at position 4. It is an antipsychotic drug used for the treatment of Schizophrenia, and other mood disorders.	3.58	2	0	aromatic ether; delta-lactam; dichlorobenzene; N-alkylpiperazine; N-arylpiperazine; quinolone	drug metabolite; H1-receptor antagonist; second generation antipsychotic; serotonergic agonist
remifentanil Remifentanil: A piperidine-propionate derivative and opioid analgesic structurally related to FENTANYL. It functions as a short-acting MU OPIOID RECEPTOR agonist, and is used as an analgesic during induction or maintenance of general anesthesia, following surgery, during childbirth, and in mechanically ventilated patients under intensive care.. remifentanil : A piperidinecarboxylate ester that is methyl piperidine-4-carboxylate in which the hydrogen attached to the nitrogen is substituted by a 3-methoxy-3-oxopropyl group and the hydrogen at position 4 is substituted the nitrogen of N-propanoylaniline.	3.85	3	0	alpha-amino acid ester; anilide; monocarboxylic acid amide; piperidinecarboxylate ester	intravenous anaesthetic; mu-opioid receptor agonist; opioid analgesic; sedative
atorvastatin [no description available]	3.23	1	0	aromatic amide; dihydroxy monocarboxylic acid; monofluorobenzenes; pyrroles; statin (synthetic)	environmental contaminant; xenobiotic
lamivudine [no description available]	3.85	3	0	monothioacetal; nucleoside analogue; oxacycle; primary alcohol	allergen; anti-HBV agent; antiviral drug; EC 2.7.7.49 (RNA-directed DNA polymerase) inhibitor; HIV-1 reverse transcriptase inhibitor; prodrug
duloxetine [no description available]	3.23	1	0	duloxetine
irinotecan [no description available]	3.85	3	0	carbamate ester; delta-lactone; N-acylpiperidine; pyranoindolizinoquinoline; ring assembly; tertiary alcohol; tertiary amino compound	antineoplastic agent; apoptosis inducer; EC 5.99.1.2 (DNA topoisomerase) inhibitor; prodrug
valsartan Valsartan: A tetrazole derivative and ANGIOTENSIN II TYPE 1 RECEPTOR BLOCKER that is used to treat HYPERTENSION.. valsartan : A monocarboxylic acid amide consisting of L-valine in which the amino hydrogens have been replaced by a pentanoyl and a [2'-(1H-tetrazol-5-yl)biphenyl]-4-yl]methyl group. It exhibits antihypertensive activity.	3.85	3	0	biphenylyltetrazole; monocarboxylic acid amide; monocarboxylic acid	angiotensin receptor antagonist; antihypertensive agent; environmental contaminant; xenobiotic
ibandronic acid Ibandronic Acid: Aminobisphosphonate that is a potent inhibitor of BONE RESORPTION. It is used in the treatment of HYPERCALCEMIA associated with malignancy, for the prevention of fracture and bone complications in patients with breast cancer and bone metastases, and for the treatment and prevention of POSTMENOPAUSAL OSTEOPOROSIS.	3.58	2	0
ziprasidone ziprasidone: a benzisothiazoylpiperazine derivative; has combined dopamine and serotonin receptor antagonist activity; structurally related to tiospirone. ziprasidone : A piperazine compound having 1,2-benzothiazol-3-yl- and 2-(6-chloro-1,3-dihydro-2-oxindol-5-yl)ethyl substituents attached to the nitrogen atoms.	3.85	3	0	1,2-benzisothiazole; indolones; organochlorine compound; piperazines	antipsychotic agent; dopaminergic antagonist; histamine antagonist; muscarinic antagonist; psychotropic drug; serotonergic antagonist
zanamivir Zanamivir: A guanido-neuraminic acid that is used to inhibit NEURAMINIDASE.	2.45	2	0	guanidines	antiviral agent; EC 3.2.1.18 (exo-alpha-sialidase) inhibitor
zolmitriptan zolmitriptan: an antimigraine compound; a serotonin (5HT)-1D receptor agonist. zolmitriptan : A member of the class of tryptamines that is N,N-dimethyltryptamine in which the hydrogen at position 5 of the indole ring has been replaced by a [(4S)-2-oxo-1,3-oxazolidin-4-yl]methyl group. A serotonin 5-HT1 B and D receptor agonist, it is used for the treatment of migraine.	3.85	3	0	oxazolidinone; tryptamines	anti-inflammatory drug; serotonergic agonist; vasoconstrictor agent
emtricitabine Emtricitabine: A deoxycytidine analog and REVERSE TRANSCRIPTASE INHIBITOR with antiviral activity against HIV-1 and HEPATITIS B viruses. It is used to treat HIV INFECTIONS.. emtricitabine : An organofluorine compound that is 5-fluorocytosine substituted at the 1 position by a 2-(hydroxymethyl)-1,3-oxathiolan-5-yl group (2R,5S configuration). It is used in combination therapy for the treatment of HIV-1 infection.	3.23	1	0	monothioacetal; nucleoside analogue; organofluorine compound; pyrimidone	antiviral drug; HIV-1 reverse transcriptase inhibitor
tasosartan tasosartan: angiotensin II antagonist; structure given in first source	3.23	1	0	biphenyls
tiludronic acid tiludronic acid: a bone resorption inhibitor; an antihypercalcemic agent; used in the tratment of Paget's disease; used in the treatment and prevention of osteoporosis; structure given in first source	3.23	1	0	organochlorine compound
tirofiban Tirofiban: Tyrosine analog and PLATELET GLYCOPROTEIN GPIIB-IIIA COMPLEX antagonist that inhibits PLATELET AGGREGATION and is used in the treatment of ACUTE CORONARY SYNDROME.. tirofiban : A member of the class of piperidines that is L-tyrosine in which a hydrogen attached to the amino group is replaced by a butylsulfonyl group and in which the hydrogen attached to the phenolic hydroxy group is replaced by a 4-(piperidin-4-yl)butyl group.	3.85	3	0	L-tyrosine derivative; piperidines; sulfonamide	anticoagulant; fibrin modulating drug; platelet glycoprotein-IIb/IIIa receptor antagonist
capecitabine Capecitabine: A deoxycytidine derivative and fluorouracil PRODRUG that is used as an ANTINEOPLASTIC ANTIMETABOLITE in the treatment of COLON CANCER; BREAST CANCER and GASTRIC CANCER.. capecitabine : A carbamate ester that is cytidine in which the hydrogen at position 5 is replaced by fluorine and in which the amino group attached to position 4 is converted into its N-(penyloxy)carbonyl derivative. Capecitabine is a antineoplastic agent used in the treatment of cancers.	3.23	1	0	carbamate ester; cytidines; organofluorine compound	antimetabolite; antineoplastic agent; prodrug
adenosine quinquefolan B: isolated from roots of Panax quinquefolium L.; RN not in Chemline 10/87; RN from Toxlit	4.12	4	0	adenosines; purines D-ribonucleoside	analgesic; anti-arrhythmia drug; fundamental metabolite; human metabolite; vasodilator agent
2,5-bis(1-aziridinyl)-3,6-bis(2-methoxyethoxy)-4-benzoquinone 2,5-bis(1-aziridinyl)-3,6-bis(2-methoxyethoxy)-4-benzoquinone: structure	2.04	1	0	1,4-benzoquinones
octyl gallate [no description available]	2.44	2	0	gallate ester	food antioxidant; hypoglycemic agent; plant metabolite
morzid morzid: structure	2.04	1	0	morpholines
potassium phosphate potassium phosphate: used in dental materials and to treat hypophosphatemia; RN given refers to cpd with unspecified MF. tripotassium phosphate : An inorganic potassium salt that is the tripotassium salt of phosphoric acid.	2.04	1	0	inorganic phosphate salt; inorganic potassium salt
cisatracurium cisatracurium: RN refers to (1R-(1alpha,2alpha(1'R,2'R)))-isomer. cisatracurium : A diester that is the (1R,1'R,2R,2'R)-diastereoisomer of atracurium, a quaternary ammonium ion consisting of pentane-1,5-diol with both hydroxy functions bearing 3-[1-(3,4-dimethoxybenzyl)-6,7-dimethoxy-2-methyl-3,4-dihydroisoquinolinium-2(1H)-yl]propanoyl groups. The active species in the skeletal muscle relaxant cisatracurium besylate.	2.04	1	0	diester; quaternary ammonium ion	muscle relaxant; nicotinic antagonist
fosinoprilat fosinoprilat: active phosphinic acid metabolite of prodrug fosenopril, which is activated by esterases in vivo; structure given in first source; binds zinc with phosphinic acid group. fosinoprilat : A phosphinic acid-containing N-acyl derivative of (4S)-cyclohexyl-L-proline. An inhibitor of angiotensin converting enzyme (ACE), it is used as the phosphinate ester pro-drug fosinopril for treatment of hypertension and chronic heart failure.	2.04	1	0	L-proline derivative; phosphinic acids	antihypertensive agent; EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor
trovafloxacin trovafloxacin: a trifluoronaphthyridone derivative of 7-(3-azabicyclo(3.1.0)hexyl)naphthyridone; has antineoplastic activity. trovafloxacin : A 1,8-naphthyridine derivative that is 4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid bearing additional 2,4-difluorophenyl, fluoro and 6-amino-3-azabicyclo[3.1.0]hex-3-yl substituents at positions 1, 6 and 7 respectively. A broad-spectrum antibiotic that was withdrawn from the market due to risk of liver failure.	9.22	5	0
cefprozil [no description available]	3.58	2	0	cephalosporin; semisynthetic derivative	antibacterial drug
febrifugine febrifugine: antimalarials; structure	2.04	1	0	quinazolines
efavirenz efavirenz: HIV-1 reverse transcriptase inhibitor. efavirenz : 1,4-Dihydro-2H-3,1-benzoxazin-2-one substituted at the 4 position by cyclopropylethynyl and trifluoromethyl groups (S configuration) and at the 6 position by chlorine. A non-nucleoside reverse transcriptase inhibitor with activity against HIV, it is used with other antiretrovirals for combination therapy of HIV infection.	3.23	1	0	acetylenic compound; benzoxazine; cyclopropanes; organochlorine compound; organofluorine compound	antiviral drug; HIV-1 reverse transcriptase inhibitor
nelfinavir Nelfinavir: A potent HIV protease inhibitor. It is used in combination with other antiviral drugs in the treatment of HIV in both adults and children.. nelfinavir : An aryl sulfide that is used (as its mesylate salt) for treatment of HIV and also exhibits some anticancer properties.	3.23	1	0	aryl sulfide; benzamides; organic heterobicyclic compound; phenols; secondary alcohol; tertiary amino compound	antineoplastic agent; HIV protease inhibitor
glucose, (beta-d)-isomer beta-D-glucose : D-Glucopyranose with beta configuration at the anomeric centre.. (1->4)-beta-D-glucan : A beta-D-glucan in which the glucose units are connected by (1->4) linkages.. (1->3)-beta-D-glucan : A beta-D-glucan in which the glucose units are connected by (1->3) linkages.	2.71	3	0	D-glucopyranose	epitope; mouse metabolite
fenofibric acid fenofibric acid: RN given refers to parent cpd without isomeric designation; structure. fenofibric acid : A monocarboxylic acid that is 2-methylpropanoic acid substituted by a 4-(4-chlorobenzoyl)phenoxy group at position 2. It is a metabolite of the drug fenofibrate.	3.23	1	0	aromatic ketone; chlorobenzophenone; monocarboxylic acid	drug metabolite; marine xenobiotic metabolite
sulfadiazine, trimethoprim drug combination sulfadiazine, trimethoprim drug combination: combination of trimethoprim & sulfadiazine	1.99	1	0
ursolic acid [no description available]	7.15	1	0	hydroxy monocarboxylic acid; pentacyclic triterpenoid	geroprotector; plant metabolite
plerixafor plerixafor: a bicyclam derivate, highly potent & selective inhibitor of HIV-1 & HIV-2. plerixafor : An azamacrocycle consisting of two cyclam rings connected by a 1,4-phenylenebis(methylene) linker. It is a CXCR4 chemokine receptor antagonist and a hematopoietic stem cell mobilizer. It is used in combination with grulocyte-colony stimulating factor (G-CSF) to mobilize hematopoietic stem cells to the perpheral blood for collection and subsequent autologous transplantation in patients with non-Hodgkin's lymphoma and multiple myeloma.	3.23	1	0	azacycloalkane; azamacrocycle; benzenes; crown amine; secondary amino compound; tertiary amino compound	anti-HIV agent; antineoplastic agent; C-X-C chemokine receptor type 4 antagonist; immunological adjuvant
amprenavir [no description available]	3.23	1	0	carbamate ester; sulfonamide; tetrahydrofuryl ester	antiviral drug; HIV protease inhibitor
oseltamivir Oseltamivir: An acetamido cyclohexene that is a structural homolog of SIALIC ACID and inhibits NEURAMINIDASE.. oseltamivir : A cyclohexenecarboxylate ester that is the ethyl ester of oseltamivir acid. An antiviral prodrug (it is hydrolysed to the active free carboxylic acid in the liver), it is used to slow the spread of influenza.	3.23	1	0	acetamides; amino acid ester; cyclohexenecarboxylate ester; primary amino compound	antiviral drug; EC 3.2.1.18 (exo-alpha-sialidase) inhibitor; environmental contaminant; prodrug; xenobiotic
allicin [no description available]	2.03	1	0	botanical anti-fungal agent; sulfoxide	antibacterial agent
thymine arabinoside thymine arabinoside: selectively inhibits replication of herpes simplex virus	2.04	1	0	N-glycosyl compound
epigallocatechin gallate epigallocatechin gallate: a steroid 5alpha-reductase inhibitor and antimutagen in green tea (Camellia sinensis). (-)-epigallocatechin 3-gallate : A gallate ester obtained by the formal condensation of gallic acid with the (3R)-hydroxy group of (-)-epigallocatechin.	2.96	4	0	flavans; gallate ester; polyphenol	antineoplastic agent; antioxidant; apoptosis inducer; geroprotector; Hsp90 inhibitor; neuroprotective agent; plant metabolite
gallocatechol gallocatechol: structure give in first source; RN given for (trans-(+-))-omer; inhibits DNA-dependent DNA & RNA polymerases. (+)-gallocatechin : A gallocatechin that has (2R,3S)-configuration. It is found in green tea and bananas.. gallocatechin : A catechin that is a flavan substituted by hydroxy groups at positions 3, 3', 4', 5, 5' and 7 (the trans isomer). It is isolated from Acacia mearnsii.	2.03	1	0	gallocatechin	antioxidant; metabolite; radical scavenger
psicofuranine [no description available]	2.04	1	0	psicose derivative; purine nucleoside
4-methylumbelliferyl phosphate [no description available]	1.98	1	0
metaperiodate Periodic Acid: A strong oxidizing agent.	1.98	1	0	iodine oxoacid
1,2,3,4,6-pentakis-O-galloyl-beta-D-glucose pentagalloylglucose: pentahydroxy gallic acid ester of glucose; a phytogenic antineoplastic agent and antibacterial agent. 1,2,3,4,6-pentakis-O-galloyl-beta-D-glucose : A galloyl-beta-D-glucose compound having five galloyl groups in the 1-, 2-, 3-, 4- and 6-positions.	2.15	1	0	gallate ester; galloyl beta-D-glucose	anti-inflammatory agent; antineoplastic agent; geroprotector; hepatoprotective agent; plant metabolite; radiation protective agent; radical scavenger
triciribine [no description available]	2.04	1	0	nucleoside analogue	EC 2.7.1.137 (phosphatidylinositol 3-kinase) inhibitor
iopamidol Iopamidol: A non-ionic, water-soluble contrast agent which is used in myelography, arthrography, nephroangiography, arteriography, and other radiological procedures.. iopamidol : A benzenedicarboxamide compound having N-substituted carbamoyl groups at the 1- and 3-positions, iodo substituents at the 2-, 4- and 6-positions and a (2S)-2-hydroxypropanamido group at the 5-position.	2.04	1	0	benzenedicarboxamide; organoiodine compound; pentol	environmental contaminant; radioopaque medium; xenobiotic
5-chloro-2'-deoxyuridine [no description available]	2.04	1	0
histamine phosphate histamine phosphate : A phosphate salt that is the diphosphate salt of histamine.	3.23	1	0	phosphate salt	histamine agonist
cephalosporin c cephalosporin C: RN given refers to parent cpd; structure in Merck, 9th ed, #1937. cephalosporin C : A cephalosporin antibiotic carrying a 3-acetoxymethyl substituent and a 6-oxo-N(6)-L-lysino group at position 7.	16.88	132	5	cephalosporin	fungal metabolite
imipramine n-oxide imipramine N-oxide: RN given refers to parent cpd; structure	2.04	1	0	dibenzooxazepine
tilbroquinol [no description available]	3.23	1	0	organohalogen compound; quinolines
bendamustine [no description available]	3.58	2	0	benzimidazoles
droxicam droxicam: structure given in first source. droxicam : An organic heterotricyclic compound that is 2H,5H-[1,3]oxazino[5,6-c][1,2]benzothiazine-2,4(3H)-dione 6,6-dioxide substituted at positions 3 and 5 by pyridin-2-yl and methyl groups respectively. A prodrug of piroxicam, it is used for the relief of pain and inflammation in musculoskeletal disorders such as rheumatoid arthritis and osteoarthritis.	3.23	1	0	organic heterotricyclic compound; pyridines	cyclooxygenase 1 inhibitor; hepatotoxic agent; non-narcotic analgesic; non-steroidal anti-inflammatory drug; platelet aggregation inhibitor; prodrug
trofosfamide trofosfamide: cyclophosphamide analog; structure	2.04	1	0	ifosfamides
4-aminobenzoic acid-n-xyloside 4-aminobenzoic acid-N-xyloside: K 247 refers to Na salt; RN given refers to (D)-isomer	2.04	1	0
fotrin fotrin: ethyleneamine derivative; antineoplastic; Russian drug; structure	2.04	1	0
sufosfamide sufosfamide: stronger immunosuppressive activity than cyclophosphamide; structure	2.04	1	0
ebrotidine ebrotidine: an H2-receptor antagonist and gastric mucosa protector	3.23	1	0	sulfonamide
fropenem [no description available]	2.46	2	0	faropenem
dexloxiglumide dexloxiglumide: a CCK receptor antagonist; structure given in first source	2.45	2	0	glutamic acid derivative
intoplicine intoplicine: structure in first source	2.04	1	0	pyridoindole
repaglinide [no description available]	3.85	3	0	piperidines
telmisartan Telmisartan: A biphenyl compound and benzimidazole derivative that acts as an angiotensin II type 1 receptor antagonist. It is used in the management of HYPERTENSION.. telmisartan : A member of the class of benzimidazoles used widely in the treatment of hypertension.	3.85	3	0	benzimidazoles; biphenyls; carboxybiphenyl	angiotensin receptor antagonist; antihypertensive agent; EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor; environmental contaminant; xenobiotic
propatyl nitrate propatyl nitrate: structure given in first source	2.04	1	0	nitrate ester
dexfenfluramine Dexfenfluramine: The S-isomer of FENFLURAMINE. It is a serotonin agonist and is used as an anorectic. Unlike fenfluramine, it does not possess any catecholamine agonist activity.. (S)-fenfluramine : The S-enantiomer of fenfluramine. It stimulates the release of serotonin and selectively inhibits its reuptake, but unlike fenfluramine it does not possess catecholamine agonist activity. It was formerly given by mouth as the hydrochloride in the treatment of obesity, but, like fenfluramine, was withdrawn wolrdwide following reports of valvular heart defects.	2.44	2	0	fenfluramine	appetite depressant; serotonergic agonist; serotonin uptake inhibitor
sulfamidochrysoidine sulfamidochrysoidine: RN given refers to parent cpd; structure. prontosil : A diphenyldiazene compound having two amino substituents at the 2- and 4-positions and an aminosulphonyl substituent at the 4'-position. It was the first antibacterial drug, (introduced 1935) and the first of the sulfonamide antibiotics.	2.04	1	0
ethinyl estradiol-17-sulfate ethinyl estradiol-17-sulfate: RN given refers to the (17alpha)-isomer	2.04	1	0
2,4-diaminopyrimidine 2,6-diaminopyrimidine: structure in first source. pyrimidine-2,4-diamine : An aminopyrimidine in which a pyrimidine nucleus is substituted with amino groups at C-2 and C-4.	2.05	1	0	aminopyrimidine
1,7-phenanthroline [no description available]	1.94	1	0	phenanthroline
triazoles Triazoles: Heterocyclic compounds containing a five-membered ring with two carbon atoms and three nitrogen atoms with the molecular formula C2H3N3.. triazoles : An azole in which the five-membered heterocyclic aromatic skeleton contains three N atoms and two C atoms.	2.06	1	0	1,2,3-triazole
deuteroporphyrin-ix [no description available]	2.15	1	0
ibopamine ibopamine: structure given in UD 31;67a & in 2nd source	2.04	1	0	benzoate ester; phenols
ethinylestradiol-3-sulfate ethinylestradiol-3-sulfate: binds to albumin at 2 sites	2.04	1	0	17beta-hydroxy steroid; steroid sulfate	antineoplastic agent; estrogen
sertraline Sertraline: A selective serotonin uptake inhibitor that is used in the treatment of depression.. sertraline : A member of the class of tetralins that is tetralin which is substituted at positions 1 and 4 by a methylamino and a 3,4-dichlorophenyl group, respectively (the S,S diastereoisomer). A selective serotonin-reuptake inhibitor (SSRI), it is administered orally as the hydrochloride salt as an antidepressant for the treatment of depression, obsessive-compulsive disorder, panic disorder and post-traumatic stress disorder.	3.23	1	0	dichlorobenzene; secondary amino compound; tetralins	antidepressant; serotonin uptake inhibitor
sanguinarine chloride [no description available]	2.07	1	0
cefcanel cefcanel: RN given refers to (6R-(6 alpha,7 beta(R*)))-isomer; structure	2.04	1	0
pumitepa pumitepa: structure; RN given refers to unlabeled cpd	2.04	1	0
arbekacin arbekacin: structure given in first source. arbekacin : A kanamycin that is kanamycin B bearing an N-(2S)-4-amino-2-hydroxybutyryl group on the aminocyclitol ring.	9.26	5	0	aminoglycoside; kanamycins	antibacterial agent; antibacterial drug; antimicrobial agent; protein synthesis inhibitor
rilmenidine Rilmenidine: Oxazole derivative that acts as an agonist for ALPHA-2 ADRENERGIC RECEPTORS and IMIDAZOLINE RECEPTORS. It is used in the treatment of HYPERTENSION.	2	1	0	isourea
zoledronic acid Zoledronic Acid: An imidobisphosphonate inhibitor of BONE RESORPTION that is used for the treatment of malignancy-related HYPERCALCEMIA; OSTEITIS DEFORMANS; and OSTEOPOROSIS.. zoledronic acid : An imidazole compound having a 2,2-bis(phosphono)-2-hydroxyethane-1-yl substituent at the 1-position.	3.85	3	0	1,1-bis(phosphonic acid); imidazoles	bone density conservation agent
epristeride epristeride: structure given in first source	2.45	2	0	steroid acid
talinolol [no description available]	2.45	2	0	ureas
elmustine elmustine: structure	2.04	1	0
forphenicinol [no description available]	2.04	1	0
leucyl-glycyl-glycine leucyl-glycyl-glycine: RN given refers to (L-Leu)-isomer. Leu-Gly-Gly : A tripeptide composed of one L-leucine and two glycine residues joined in sequence.	2.44	2	0	tripeptide	metabolite
dipropylacetamide dipropylacetamide: structure. valpromide : A fatty amide derived from valproic acid.	2.04	1	0	fatty amide	geroprotector; metabolite; teratogenic agent
denaverine denaverine: RN given refers to parent cpd; structure	2.04	1	0	diarylmethane
acamprosate Acamprosate: Structural analog of taurine that is used for the prevention of relapse in individuals with ALCOHOLISM.. acamprosate : An organosulfonic acid that is propane-1-sulfonic acid substituted by an acetylamino group at position 3.	3.23	1	0	acetamides; organosulfonic acid	environmental contaminant; neurotransmitter agent; xenobiotic
isaxonine isaxonine: promotes nerve growth	3.23	1	0	aminopyrimidine
enrofloxacin Enrofloxacin: A fluoroquinolone antibacterial and antimycoplasma agent that is used in veterinary practice.. enrofloxacin : A quinolinemonocarboxylic acid that is 1,4-dihydroquinoline-3-carboxylic acid substituted by an oxo group at position 4, a fluoro group at position 6, a cyclopropyl group at position 1 and a 4-ethylpiperazin-1-yl group at position 7. It is a veterinary antibacterial agent used for the treatment of pets.	3.18	5	0	cyclopropanes; N-alkylpiperazine; N-arylpiperazine; organofluorine compound; quinolinemonocarboxylic acid; quinolone	antibacterial agent; antimicrobial agent; antineoplastic agent
diprafenone diprafenone: structure given in first source	2.72	3	0	aromatic compound
nebivolol 2,2'-iminobis[1-(6-fluoro-3,4-dihydro-2H-chromen-2-yl)ethanol] : A member of the class of chromanes that is 2,2'-iminodiethanol in which one hydrogen attached to each hydroxy-bearing carbon is replaced by a 6-fluorochroman-2-yl group.	3.58	2	0	chromanes; diol; organofluorine compound; secondary alcohol; secondary amino compound
uk 68798 [no description available]	4.06	4	0	aromatic ether; sulfonamide; tertiary amino compound	anti-arrhythmia drug; potassium channel blocker
ljc 10627 biapenem: structure given in first source. biapenem : A carbapenem antibiotic in which the azetidine and pyrroline rings carry 1-hydroxymethyl and pyrazolo[1,2-a][1,2,4]triazolium-6-ylthio substituents respectively.	2.45	2	0	carbapenems; organic sulfide; pyrazolotriazole	antibacterial drug
hp 873 iloperidone: an atypical, negative symptom antipsychotic agent. iloperidone : A member of the class of piperidines that is the 4-acetyl-2-methoxyphenyl ether of 3-(piperidin-1-yl)propan-1-ol which is substituted at position 4 of the piperidine ring by a 6-fluoro-1,2-benzoxazol-3-yl group. A member of the group of second generation antipsychotics (also known as an atypical antipsychotics), it is used for the treatment of schizophrenia.	3.23	1	0	1,2-benzoxazoles; aromatic ether; aromatic ketone; methyl ketone; monoamine; organofluorine compound; piperidines; tertiary amino compound	dopaminergic antagonist; second generation antipsychotic; serotonergic antagonist
dexrazoxane Dexrazoxane: The (+)-enantiomorph of razoxane.	3.85	3	0	razoxane	antineoplastic agent; cardiovascular drug; chelator; immunosuppressive agent
fenoxypropazine [no description available]	3.23	1	0	aromatic ether
voriconazole Voriconazole: A triazole antifungal agent that specifically inhibits STEROL 14-ALPHA-DEMETHYLASE and CYTOCHROME P-450 CYP3A.. voriconazole : A triazole-based antifungal agent used for the treatment of esophageal candidiasis, invasive pulmonary aspergillosis, and serious fungal infections caused by Scedosporium apiospermum and Fusarium spp. It is an inhibitor of cytochrome P450 2C9 (CYP2C9) and CYP3A4.	3.58	2	0	conazole antifungal drug; difluorobenzene; pyrimidines; tertiary alcohol; triazole antifungal drug	P450 inhibitor
inproquone inproquone: major descriptor (78-80); replaced major descriptor Bayer E39 (63-77); on-line search AZIRINES (66-80); Index Medicus search Bayer E39 (63-77), INPROQUONE (78-80)	2.04	1	0
betamipron [no description available]	2.04	1	0	organonitrogen compound; organooxygen compound
penicillin n penicillin N: RN given refers to (2S-(2alpha,5alpha,6beta(S*)))-isomer; structure in Merck, 9th ed, #6887	2.07	1	0	penicillin
bufuralol bufuralol: RN given refers to cpd without isomeric designation; structure	2.72	3	0	benzofurans
aceclofenac [no description available]	3.23	1	0	amino acid; carboxylic ester; dichlorobenzene; monocarboxylic acid; secondary amino compound	EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor; non-narcotic analgesic; non-steroidal anti-inflammatory drug
nitrefazole [no description available]	3.23	1	0	imidazoles
epanolol epanolol: structure given in first source	2	1	0	acetamides
panipenem panipenem: synthetic cpd; structure given in first source	2.42	2	0	organic molecular entity
perindoprilat perindoprilat : A dipeptide obtained by formal condensation of one of the carboxy groups of N-[(1S)-1-carboxyethyl]-L-norvaline with the amino group of (2S,3aS,7aS)-octahydroindole-2-carboxylic acid. The major active metabolite of perindopril.	2.04	1	0	dicarboxylic acid; dipeptide; L-alanine derivative; organic heterobicyclic compound	antihypertensive agent; drug metabolite; EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor
7-hydroxystaurosporine [no description available]	2.04	1	0
methotrimeprazine Methotrimeprazine: A phenothiazine with pharmacological activity similar to that of both CHLORPROMAZINE and PROMETHAZINE. It has the histamine-antagonist properties of the antihistamines together with CENTRAL NERVOUS SYSTEM effects resembling those of chlorpromazine. (From Martindale, The Extra Pharmacopoeia, 30th ed, p604). methotrimeprazine : A member of the class of phenothiazines that is 10H-phenothiazine substituted by a (2R)-3-(dimethylamino)-2-methylpropyl group and a methoxy group at positions 10 and 2 respectively.	2.42	2	0	phenothiazines; tertiary amine	anticoronaviral agent; cholinergic antagonist; dopaminergic antagonist; EC 3.4.21.26 (prolyl oligopeptidase) inhibitor; non-narcotic analgesic; phenothiazine antipsychotic drug; serotonergic antagonist
magnolol [no description available]	2.11	1	0	biphenyls
honokiol [no description available]	2.11	1	0	biphenyls
gentamicin c1 [no description available]	2.96	3	0
gentamicin c1a [no description available]	3.81	9	0	gentamycin C
9-aminocamptothecin [no description available]	2.04	1	0	pyranoindolizinoquinoline
sch 34343 Sch 34343: structure given in first source; RN given refers to (5R-(5alpha,6alpha))-isomer	2.45	2	0
grepafloxacin grepafloxacin: structure in first source	1.99	1	0	fluoroquinolone antibiotic; quinolines; quinolone antibiotic
squalamine squalamine: from dogfish shark Squalus acanthias; structure given in first source	2.04	1	0	bile acid
alkannin alkannin: a naphthazarin used to promote wound healing, from the plant Alkanna tinctoria; RN given refers to (S)-isomer; structure	2.01	1	0	hydroxy-1,4-naphthoquinone
vexibinol vexibinol: flavanol from Sophora; structure in first source; RN given refers to (S-(R,S))-isomer. sophoraflavanone G : A tetrahydroxyflavanone having a structure of naringenin bearing an additional hydroxyl substituent at position 2' as well as a (2R)-5-methyl-2-(prop-1-en-2-yl)hex-4-en-1-yl (lavandulyl) substituent at position 8'.	2.05	1	0	(2S)-flavan-4-one; 4'-hydroxyflavanones; tetrahydroxyflavanone	antimalarial; antimicrobial agent; antioxidant; plant metabolite
neplanocin a neplanocin A: neplanocins are antitumor antibiotics & carbocyclic analogs of purine nucleosides from Ampullarilla regularis A11079; see also neplanocin B, neplanocin C, neplanocin D & neplanocin F; structure in first source; a potent inhibitor of S-adenosylhomocysteine hydrolase	2.04	1	0
doripenem Doripenem: A carbapenem derivative antibacterial agent that is more stable to renal dehydropeptidase I than IMIPENEM, but does not need to be given with an enzyme inhibitor such as CILASTATIN. It is used in the treatment of infections such as HOSPITAL-ACQUIRED PNEUMONIA, and complicated intra-abdominal or urinary-tract infections, including PYELONEPHRITIS.	3.57	2	0	carbapenems
corilagin corilagin: isolated from Geranii herba. corilagin : An ellagitannin with a hexahydroxydiphenoyl group bridging over the 3-O and 6-O of the glucose core.	2.42	2	0	ellagitannin; gallate ester	antihypertensive agent; antioxidant; EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor; non-steroidal anti-inflammatory drug
glycyl-histidyl-lysine glycyl-histidyl-lysine: found in human plasma; promotes proliferation of hepatoma cells, lymphocytes & mycoplsma; maintains viability of hepatocytes, eosinophils and macrophages; inhibits growth of glial cells; RN given refers to (L)-isomer. Gly-His-Lys : A tripeptide composed of glycine, L-histidine and L-lysine residues joined in sequence.	2.06	1	0	tripeptide	chelator; hepatoprotective agent; metabolite; vulnerary
oxazolidin-2-one Oxazolidinones: Derivatives of oxazolidin-2-one. They represent an important class of synthetic antibiotic agents.. oxazolidin-2-one : An oxazolidinone that is 1,3-oxazolidine with an oxo substituent at position 2.. oxazolidinone : An oxazolidine containing one or more oxo groups.	5.57	16	1	carbamate ester; oxazolidinone	metabolite
atovaquone Atovaquone: A hydroxynaphthoquinone that has antimicrobial activity and is being used in antimalarial protocols.. atovaquone : A naphthoquinone compound having a 4-(4-chlorophenyl)cyclohexyl group at the 2-position and a hydroxy substituent at the 3-position.	4.06	4	0	hydroxy-1,2-naphthoquinone
1-ethoxysilatrane [no description available]	2.04	1	0
rivastigmine [no description available]	3.85	3	0	carbamate ester; tertiary amino compound	cholinergic drug; EC 3.1.1.8 (cholinesterase) inhibitor; neuroprotective agent
frovatriptan [no description available]	3.85	3	0	carbazoles
eletriptan eletriptan: 5-HT(1B/1D) receptor agonist; structure in first source. eletriptan : An N-alkylpyrrolidine, that is N-methylpyrrolidine in which the pro-R hydrogen at position 2 is replaced by a {5-[2-(phenylsulfonyl)ethyl]-1H-indol-3-yl}methyl group.	3.58	2	0	indoles; N-alkylpyrrolidine; sulfone	non-steroidal anti-inflammatory drug; serotonergic agonist; vasoconstrictor agent
rosiglitazone [no description available]	3.85	3	0	aminopyridine; thiazolidinediones	EC 6.2.1.3 (long-chain-fatty-acid--CoA ligase) inhibitor; ferroptosis inhibitor; insulin-sensitizing drug
2-aminoimidazole 2-aminoimidazole: from catabolism of arginine	2.06	1	0
bexarotene [no description available]	3.23	1	0	benzoic acids; naphthalenes; retinoid	antineoplastic agent
alanylproline alanylproline: RN given refers to all (L)-isomer	2.06	1	0	dipeptide zwitterion; dipeptide	metabolite
clarithromycin Clarithromycin: A semisynthetic macrolide antibiotic derived from ERYTHROMYCIN that is active against a variety of microorganisms. It can inhibit PROTEIN SYNTHESIS in BACTERIA by reversibly binding to the 50S ribosomal subunits. This inhibits the translocation of aminoacyl transfer-RNA and prevents peptide chain elongation.. clarithromycin : The 6-O-methyl ether of erythromycin A, clarithromycin is a macrolide antibiotic used in the treatment of respiratory-tract, skin and soft-tissue infections. It is also used to eradicate Helicobacter pylori in the treatment of peptic ulcer disease. It prevents bacteria from growing by interfering with their protein synthesis.	4.78	9	0	macrolide antibiotic	antibacterial drug; environmental contaminant; protein synthesis inhibitor; xenobiotic
3-phenyl-5-methylisoxazole-4-carbonyl chloride [no description available]	1.96	1	0
coenzyme a [no description available]	2.1	1	0	adenosine 3',5'-bisphosphate	coenzyme; Escherichia coli metabolite; mouse metabolite
Trp-Trp tryptophyltryptophan: an antigelation agent. Trp-Trp : A dipeptide formed from two L-tryptophan residues.	2.06	1	0	dipeptide	Mycoplasma genitalium metabolite
tretazicar tretazicar: minor descriptor (75-84); on-line & Index Medicus search AZIRIDINES (75-84)	2.04	1	0
nicotine (S)-nicotine : A 3-(1-methylpyrrolidin-2-yl)pyridine in which the chiral centre has S-configuration. The naturally occurring and most active enantiomer of nicotine, isolated from Nicotiana tabacum.	2.72	3	0	3-(1-methylpyrrolidin-2-yl)pyridine	anxiolytic drug; biomarker; immunomodulator; mitogen; neurotoxin; nicotinic acetylcholine receptor agonist; peripheral nervous system drug; phytogenic insecticide; plant metabolite; psychotropic drug; teratogenic agent; xenobiotic
nsc-172755 butocin: S-substituted analog of mercaptopurine which functions as a cytostatic agent; minor descriptor (75-85); on-line search 6-MERCAPTOPURINE/AA (75-84); Index Medicus search MERCAPTOPURINE/analogs (75-84)	2.46	2	0
abnormal cannabidiol [no description available]	2.04	1	0	monoterpenoid
fibrinogen Fibrinogen: Plasma glycoprotein clotted by thrombin, composed of a dimer of three non-identical pairs of polypeptide chains (alpha, beta, gamma) held together by disulfide bonds. Fibrinogen clotting is a sol-gel change involving complex molecular arrangements: whereas fibrinogen is cleaved by thrombin to form polypeptides A and B, the proteolytic action of other enzymes yields different fibrinogen degradation products.. D-iditol : The D-enantiomer of iditol.	1.94	1	0	iditol	fungal metabolite
moexipril [no description available]	3.23	1	0	peptide
beta-eudesmol beta-eudesmol: found in Atractylodes and other plants; RN given refers to (2R-(2alpha,4aalpha,8abeta))-isomer. beta-eudesmol : A carbobicyclic compound that is trans-decalin substituted at positions 2, 4a, and 8 by 2-hydroxypropan-2-yl, methyl and methylidene groups, respectively (the 2R,4aR,8aS-diastereoisomer).	2.15	1	0	carbobicyclic compound; eudesmane sesquiterpenoid; tertiary alcohol	volatile oil component
streptovitacin a streptovitacin A: structure	2.04	1	0
cb 10375 trimelamol: structure given in first source	2.04	1	0
mci 9038 [no description available]	3.58	2	0	peptide
propicillin propicillin: major descriptor (64-84); on-line search PENICILLIN, PHENOXYMETHYL/AA (64-84); Index Medicus search PROPICILLIN (64-84); RN given refers to parent cpd(2S-(2alpha,5alpha,6beta))-isomer	4.8	6	0	penicillin
glycidyl nitrate glycidyl nitrate: a nitric oxide donor; structure in first source. peptidoglycan : A peptidoglycosaminoglycan formed by alternating residues of beta-(1->4)-linked N-acetylglucosamine and N-acetylmuramic acid {2-amino-3-O-[(S)-1-carboxyethyl]-2-deoxy-D-glucose} residues. Attached to the carboxy group of the muramic acid is a peptide chain of three to five amino acids.	4.17	16	0
carbenicillin indanyl carbenicillin indanyl: acid stable indanyl ester of carbenicillin for oral use; same side-effects as carbenicillin; minor descriptor (75-86); on line & INDEX MEDICUS search CARBENICILLIN/AA (75-86); RN given refers to (mono-Na salt(2S-(2alpha,5alpha,6beta))-isomer)	2.04	1	0	penicillin
dodecyl glucoside dodecyl glucoside: RN given refers to (beta-D)-isomer	2.15	1	0
cb 1837 CB 1837: RN given refers to parent cpd; structure	2.04	1	0
4',5,6,7-tetramethoxyflavone 4',5,6,7-tetramethoxyflavone: structure given in first source; from plant Eupatorium odoratum. 4',5,6,7-tetramethoxyflavone : A tetramethoxyflavone that is the tetra-O-methyl derivative of scutellarein.	2.25	1	0	tetramethoxyflavone	antimutagen; plant metabolite
hexaphosphamide hexaphosphamide: structure	2.04	1	0
dipin dipin: structure	2.04	1	0
phosphazine phosphazine: structure	2.04	1	0
prolyl-glycyl-glycine prolyl-glycyl-glycine: structure given in first source	2.44	2	0	oligopeptide
eupatorin eupatorin: a flavonoid from the East Asian medicinal plant Orthosiphon spicatus; prevents oxidative inactivation of 15-lipoxygenase; structure given in first source. eupatorin : A trimethoxyflavone that is 6-hydroxyluteolin in which the phenolic hydogens at positions 4', 6 and 7 have been replaced by methyl groups.	2.25	1	0	dihydroxyflavone; polyphenol; trimethoxyflavone	anti-inflammatory agent; antineoplastic agent; apoptosis inducer; Brassica napus metabolite; calcium channel blocker; P450 inhibitor; vasodilator agent
delta(9)-tetrahydrocannabinolic acid Delta(9)-tetrahydrocannabinolic acid : A diterpenoid that is 6a,7,8,10a-tetrahydro-6H-benzo[c]chromene substituted at position 1 by a hydroxy group, positions 6, 6 and 9 by methyl groups and at position 3 by a pentyl group. A biosynthetic precursor to Delta(9)-tetrahydrocannabinol, the principal psychoactive constituent of the cannabis plant.	2.04	1	0	benzochromene; diterpenoid; hydroxy monocarboxylic acid; phytocannabinoid; polyketide	anti-inflammatory agent; biomarker; metabolite; neuroprotective agent
5'-n-methylcarboxamideadenosine 5'-N-methylcarboxamideadenosine: RN given refers to (beta-D)-isomer	2.79	3	0
diiodobenzotepa diiodobenzotepa: structure	2.04	1	0
icig 1163 ICIG 1163: RN given refers to parent cpd; structure in first source	2.04	1	0
bimolane bimolane: structure given in first source	2.04	1	0
thiodipin thiodipin: structure	2.04	1	0
fluoxydine fluoxydine: structure	2.04	1	0
imiphos imiphos: structure	2.04	1	0
4-hydroxycarbazole 4-hydroxycarbazole: structure in first source	2.41	1	0
cobalt Cobalt: A trace element that is a component of vitamin B12. It has the atomic symbol Co, atomic number 27, and atomic weight 58.93. It is used in nuclear weapons, alloys, and pigments. Deficiency in animals leads to anemia; its excess in humans can lead to erythrocytosis.. cobalt(1+) : A monovalent inorganic cation obtained from cobalt.. cobalt atom : A cobalt group element atom that has atomic number 27.	1.94	1	0	cobalt group element atom; metal allergen	micronutrient
fulvestrant Fulvestrant: An estradiol derivative and estrogen receptor antagonist that is used for the treatment of estrogen receptor-positive, locally advanced or metastatic breast cancer.. fulvestrant : A 3-hydroxy steroid that is 17beta-estradiol in which the 7alpha hydrogen has been replaced by a nonyl group in which one of the hydrogens of the terminal methyl has been replaced by a (4,4,5,5,5-pentafluoropentyl)sulfinyl group. An estrogen receptor antagonist, it is used in the treatment of breast cancer.	3.23	1	0	17beta-hydroxy steroid; 3-hydroxy steroid; organofluorine compound; sulfoxide	antineoplastic agent; estrogen antagonist; estrogen receptor antagonist
imipenem, anhydrous Imipenem: Semisynthetic thienamycin that has a wide spectrum of antibacterial activity against gram-negative and gram-positive aerobic and anaerobic bacteria, including many multiresistant strains. It is stable to beta-lactamases. Clinical studies have demonstrated high efficacy in the treatment of infections of various body systems. Its effectiveness is enhanced when it is administered in combination with CILASTATIN, a renal dipeptidase inhibitor.. imipenem : A broad-spectrum, intravenous beta-lactam antibiotic of the carbapenem subgroup.	7.74	50	1	beta-lactam antibiotic allergen; carbapenems; zwitterion	antibacterial drug
bosentan anhydrous Bosentan: A sulfonamide and pyrimidine derivative that acts as a dual endothelin receptor antagonist used to manage PULMONARY HYPERTENSION and SYSTEMIC SCLEROSIS.	3.58	2	0	primary alcohol; pyrimidines; sulfonamide	antihypertensive agent; endothelin receptor antagonist
artesunic acid [no description available]	2.48	2	0
cyanates Cyanates: Organic salts of cyanic acid containing the -OCN radical.. cyanates : Salts and esters of cyanic acid, HOC#N; compounds carrying the cyanate functional group -O-C#N.. isocyanates : Organonitrogen compounds that are derivatives of isocyanic acid; compounds containing the isocyanate functional group -N=C=O (as opposed to the cyanate group, -O-C#N).	1.95	1	0
aldophosphamide aldophosphamide: metabolite of cyclophosphamide	2.04	1	0	nitrogen mustard
perindopril Perindopril: An angiotensin-converting enzyme inhibitor. It is used in patients with hypertension and heart failure.. perindopril : An alpha-amino acid ester that is the ethyl ester of N-{(2S)-1-[(2S,3aS,7aS)-2-carboxyoctahydro-1H-indol-1-yl]-1-oxopropan-2-yl}-L-norvaline	3.58	2	0	alpha-amino acid ester; dicarboxylic acid monoester; ethyl ester; organic heterobicyclic compound	antihypertensive agent; EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor
procyanidin Proanthocyanidins: Dimers and oligomers of flavan-3-ol units (CATECHIN analogs) linked mainly through C4 to C8 bonds to leucoanthocyanidins. They are structurally similar to ANTHOCYANINS but are the result of a different fork in biosynthetic pathways.	2.03	1	0	proanthocyanidin
epicatechin gallate epicatechin gallate: a steroid 5alpha-reductase inhibitor; RN given refers to the (cis)-isomer; structure given in first source; isolated from green tea. (-)-epicatechin-3-O-gallate : A gallate ester obtained by formal condensation of the carboxy group of gallic acid with the (3R)-hydroxy group of epicatechin. A natural product found in Parapiptadenia rigida.	3.29	6	0	catechin; gallate ester; polyphenol	EC 3.2.1.1 (alpha-amylase) inhibitor; EC 3.2.1.20 (alpha-glucosidase) inhibitor; metabolite
asulacrine asulacrine: derivative of amsacrine; structure given in first source	2.04	1	0	acridines
hydroxycotinine hydroxycotinine: metabolite of nicotine; RN given refers to (S)-isomer; structure. trans-3-hydroxycotinine : An N-alkylpyrrolidine that is cotinine substituted at position C-3 by a hydroxy group (the 3R,5S-diastereomer).	2.04	1	0	N-alkylpyrrolidine; pyridines; pyrrolidin-2-ones; pyrrolidine alkaloid
quinaprilat quinaprilat: metabolite of quinapril. quinaprilat : A dicarboxylic acid resulting from the hydrolysis of the ethyl ester group of quinapril to give the corresponding dicarboxylic acid. The active angiotensin-converting enzyme inhibitor (ACE inhibitor) of the prodrug quinapril.	2.45	2	0	dicarboxylic acid; isoquinolines; tertiary carboxamide	antihypertensive agent; EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor; vasodilator agent
2-hydroxyimipramine 2-hydroxyimipramine: RN given refers to parent cpd	2.45	2	0	dibenzoazepine
ecteinascidin 743 [no description available]	2.04	1	0	acetate ester; azaspiro compound; bridged compound; hemiaminal; isoquinoline alkaloid; lactone; organic heteropolycyclic compound; organic sulfide; oxaspiro compound; polyphenol; tertiary amino compound	alkylating agent; angiogenesis modulating agent; anti-inflammatory agent; antineoplastic agent; marine metabolite
tadalafil [no description available]	3.23	1	0	benzodioxoles; pyrazinopyridoindole	EC 3.1.4.35 (3',5'-cyclic-GMP phosphodiesterase) inhibitor; vasodilator agent
3,6-bis(5-chloro-2-piperidyl)-2,5-piperazinedione 3,6-bis(5-chloro-2-piperidyl)-2,5-piperazinedione: isolated from Streptomyces griseoluteus fermentation broth; RN given refers to cpd without isomeric designation; structure	2.04	1	0
florfenicol florfenicol: structure given in first source. florfenicol : A carboxamide that is the N-dichloroacetyl derivative of (1R,2S)-2-amino-3-fluoro-1-[4-(methanesulfonyl)phenyl]propan-1-ol. A synthetic veterinary antibiotic that is used for treatment of bovine respiratory disease and foot rot; also used in aquaculture.	2.75	3	0	organochlorine compound; organofluorine compound; secondary alcohol; secondary carboxamide; sulfone	antimicrobial agent
oxymatrine oxysophoridine: an alkaloid isolated from Sophra alope; structure in first source	2.04	1	0	alkaloid; tertiary amine oxide
dodecyl-beta-d-maltoside dodecyl beta-D-maltoside : A glycoside resulting from attachment of a dodecyl group to the reducing-end anomeric centre of a beta-maltose molecule.	2.15	1	0	disaccharide derivative; glycoside	detergent
paliperidone 3-{2-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl}-9-hydroxy-2-methyl-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidin-4-one : A member of the class of pyridopyrimidines that is 9-hydroxy-2-methyl-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidin-4-one carrying an additional 2-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl group at position 2.. paliperidone : A racemate comprising equimolar amounts of (R)- and (S)-paliperidone. Paliperidone is the primary active metabolite of the older antipsychotic risperidone and is used for treatment of schizophrenia.	3.23	1	0	1,2-benzoxazoles; heteroarylpiperidine; organofluorine compound; pyridopyrimidine; secondary alcohol
nitisinone [no description available]	3.23	1	0	(trifluoromethyl)benzenes; C-nitro compound; cyclohexanones; mesotrione	EC 1.13.11.27 (4-hydroxyphenylpyruvate dioxygenase) inhibitor
clofarabine [no description available]	3.23	1	0	adenosines; organofluorine compound	antimetabolite; antineoplastic agent
1,1,2-trichloroethanol 1,1,2-trichloroethanol: metabolite of 1,1,2-trichloroethylene	2.04	1	0
pramipexole Pramipexole: A benzothiazole derivative and dopamine agonist with antioxidant properties that is used in the treatment of PARKINSON DISEASE and RESTLESS LEGS SYNDROME.. pramipexole : A member of the class of benzothiazoles that is 4,5,6,7-tetrahydro-1,3-benzothiazole in which the hydrogens at the 2 and 6-pro-S-positions are substituted by amino and propylamino groups, respectively.	3.23	1	0	benzothiazoles; diamine	antidyskinesia agent; antiparkinson drug; dopamine agonist; radical scavenger
valdecoxib [no description available]	8.61	2	0	isoxazoles; sulfonamide	antipyretic; antirheumatic drug; cyclooxygenase 2 inhibitor; non-narcotic analgesic; non-steroidal anti-inflammatory drug
ci 934 CI 934: structure given in first source	1.97	1	0
broadcillin broadcillin: combination drug containing above two cpds	4.11	16	0
imatinib mesylate imatinib methanesulfonate : A methanesulfonate (mesylate) salt that is the monomesylate salt of imatinib. Used for treatment of chronic myelogenous leukemia and gastrointestinal stromal tumours.	2.06	1	0	methanesulfonate salt	anticoronaviral agent; antineoplastic agent; apoptosis inducer; tyrosine kinase inhibitor
almotriptan almotriptan : An indole compound having a 2-(dimethylamino)ethyl group at the 3-position and a (pyrrolidin-1-ylsulfonyl)methyl group at the 5-position.	3.85	3	0	indoles; sulfonamide; tertiary amine	non-steroidal anti-inflammatory drug; serotonergic agonist; vasoconstrictor agent
mk 0663 [no description available]	2.04	1	0	bipyridines; organochlorine compound; sulfone	cyclooxygenase 2 inhibitor; non-steroidal anti-inflammatory drug
tazobactam Tazobactam: A penicillanic acid and sulfone derivative and potent BETA-LACTAMASE inhibitor that enhances the activity of other anti-bacterial agents against beta-lactamase producing bacteria.. tazobactam : A member of the class of penicillanic acids that is sulbactam in which one of the exocyclic methyl hydrogens is replaced by a 1,2,3-triazol-1-yl group; used (in the form of its sodium salt) in combination with ceftolozane sulfate for treatment of complicated intra-abdominal infections and complicated urinary tract infections.	3.64	9	0	penicillanic acids; triazoles	antiinfective agent; antimicrobial agent; EC 3.5.2.6 (beta-lactamase) inhibitor
gefitinib [no description available]	3.58	2	0	aromatic ether; monochlorobenzenes; monofluorobenzenes; morpholines; quinazolines; secondary amino compound; tertiary amino compound	antineoplastic agent; epidermal growth factor receptor antagonist
tyrosyl-glycyl-glycine tyrosyl-glycyl-glycine: RN given refers to L-isomer; this may not be the same as IMREG-1. Tyr-Gly-Gly : A tripeptide composed of one L-tyrosine and two glycine residues joined in sequence.	2.02	1	0	tripeptide zwitterion; tripeptide	metabolite
desloratadine desloratadine: major metabolite of loratadine. desloratadine : Loratadine in which the ethoxycarbonyl group attached to the piperidine ring is replaced by hydrogen. The major metabolite of loratidine, desloratadine is an antihistamine which is used for the symptomatic relief of allergic conditions including rhinitis and chronic urticaria. It does not readily enter the central nervous system, so does not cause drowsiness.	3.23	1	0	benzocycloheptapyridine	anti-allergic agent; cholinergic antagonist; drug metabolite; H1-receptor antagonist
desvenlafaxine O-desmethylvenlafaxine : A tertiary amino compound that is N,N-dimethylethanamine substituted at position 1 by a 1-hydroxycyclohexyl and 4-hydroxyphenyl group. It is a metabolite of the drug venlafaxine.	3.23	1	0	cyclohexanols; phenols; tertiary amino compound	antidepressant; drug metabolite; marine xenobiotic metabolite
6,6'-dicorynomycolyl trehalose [no description available]	1.97	1	0
iremycin iremycin: anthracycline antibiotic from Streptomyces violaceus subsp. iremyceticus; RN given refers to parent cpd(7R-trans)-isomer	2.04	1	0
methotrexate [no description available]	10.32	10	0	dicarboxylic acid; monocarboxylic acid amide; pteridines	abortifacient; antimetabolite; antineoplastic agent; antirheumatic drug; dermatologic drug; DNA synthesis inhibitor; EC 1.5.1.3 (dihydrofolate reductase) inhibitor; immunosuppressive agent
n,n'-bis((2-chloroethyl)nitrosocarbamoyl)cystamine N,N'-bis((2-chloroethyl)nitrosocarbamoyl)cystamine: structure given in first source	2.04	1	0
hainanensine hainanensine: structure in first source	2.04	1	0
tamsulosin [no description available]	3.85	3	0	5-(2-{[2-(2-ethoxyphenoxy)ethyl]amino}propyl)-2-methoxybenzenesulfonamide	alpha-adrenergic antagonist; antineoplastic agent
rufinamide rufinamide: for treatment of Lennox-Gastaut syndrome; structure in first source	3.23	1	0	aromatic amide; heteroarene
sulbactam [no description available]	5.63	18	1	penicillanic acids
olmesartan medoxomil Olmesartan Medoxomil: An ANGIOTENSIN II TYPE 1 RECEPTOR BLOCKER that is used to manage HYPERTENSION.	3.23	1	0	biphenyls
phlorofucofuroeckol a phlorofucofuroeckol A: phlorotannin from Ecklonia kurome; structure given in first source	2.08	1	0
dexpanthenol dexpanthenol: The alcohol of pantothenic acid	3.23	1	0	amino alcohol; monocarboxylic acid amide	cholinergic drug; provitamin
fosamprenavir fosamprenavir: a prodrug of the protease inhibitor amprenavir. fosamprenavir : A sulfonamide with a structure based on that of sulfanilamide substituted on the sulfonamide nitrogen by a (2R,3S)-4-phenyl-2-(phosphonooxy)-3-({[(3S)-tetrahydrofuran-3-yloxy]carbonyl}amino)butyl group. It is a pro-drug of the HIV protease inhibitor and antiretroviral drug amprenavir.	3.23	1	0	sulfonamide	prodrug
febuxostat Febuxostat: A thiazole derivative and inhibitor of XANTHINE OXIDASE that is used for the treatment of HYPERURICEMIA in patients with chronic GOUT.. febuxostat : A 1,3-thiazolemonocarboxylic acid that is 4-methyl-1,3-thiazole-5-carboxylic acid which is substituted by a 3-cyano-4-(2-methylpropoxy)phenyl group at position 2. It is an orally-active, potent, and selective xanthine oxidase inhibitor used for the treatment of chronic hyperuricaemia in patients with gout.	3.23	1	0	1,3-thiazolemonocarboxylic acid; aromatic ether; nitrile	EC 1.17.3.2 (xanthine oxidase) inhibitor
dilevalol (R,R)-labetalol : A 2-hydroxy-5-{1-hydroxy-2-[(4-phenylbutan-2-yl)amino]ethyl}benzamide that has 1R,2R-configuration.	2.04	1	0	2-hydroxy-5-{1-hydroxy-2-[(4-phenylbutan-2-yl)amino]ethyl}benzamide
carbapenems [no description available]	5.13	13	0
beta-lactams 2-azetidinone: structure in first source. azetidin-2-one : An unsubstituted beta-lactam compound.. beta-lactam : A lactam in which the amide bond is contained within a four-membered ring, which includes the amide nitrogen and the carbonyl carbon.	10.46	58	0	beta-lactam antibiotic allergen; beta-lactam
ritrosulfan ritrosulfan: RN given refers to parent cpd(R,S)-isomer; structure	2.04	1	0
sinensetin sinensetin: isolated from citrus fruit; exhibit antiadhesive action on platelets. sinensetin : A pentamethoxyflavone that is flavone substituted by methoxy groups at positions 5, 6, 7, 3' and 4' respectively.	2.25	1	0	pentamethoxyflavone	plant metabolite
escitalopram Escitalopram: S-enantiomer of CITALOPRAM. Belongs to a class of drugs known as SELECTIVE SEROTONIN REUPTAKE INHIBITORS, used to treat depression and generalized anxiety disorder.. escitalopram : A 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile that has S-configuration at the chiral centre. It is the active enantiomer of citalopram.	3.23	1	0	1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile	antidepressant; EC 3.4.21.26 (prolyl oligopeptidase) inhibitor
10-propargyl-10-deazaaminopterin 10-propargyl-10-deazaaminopterin: structure in first source. pralatrexate : A pteridine that is the N-4-[1-(2,4-diaminopteridin-6-yl)pent-4-yn-2-yl]benzoyl derivative of L-glutamic acid. Used for treatment of Peripheral T-Cell Lymphoma, an aggressive form of non-Hodgkins lymphoma.	3.23	1	0	N-acyl-L-glutamic acid; pteridines; terminal acetylenic compound	antimetabolite; antineoplastic agent; EC 1.5.1.3 (dihydrofolate reductase) inhibitor
docetaxel [no description available]	2.75	3	0	hydrate; secondary alpha-hydroxy ketone	antineoplastic agent
docetaxel anhydrous Docetaxel: A semisynthetic analog of PACLITAXEL used in the treatment of locally advanced or metastatic BREAST NEOPLASMS and NON-SMALL CELL LUNG CANCER.. docetaxel anhydrous : A tetracyclic diterpenoid that is paclitaxel with the N-benzyloxycarbonyl group replaced by N-tert-butoxycarbonyl, and the acetoxy group at position 10 replaced by a hydroxy group.	3.23	1	0	secondary alpha-hydroxy ketone; tetracyclic diterpenoid	antimalarial; antineoplastic agent; photosensitizing agent
irofulven irofulven: structure in first source	2.04	1	0	cyclohexenones
atazanavir atazanavir : A heavily substituted carbohydrazide that is an antiretroviral drug of the protease inhibitor (PI) class used to treat infection of human immunodeficiency virus (HIV).	3.23	1	0	carbohydrazide	antiviral drug; HIV protease inhibitor
ym 872 YM 872: structure in first source	2.04	1	0
levofloxacin Levofloxacin: The L-isomer of Ofloxacin.. levofloxacin : An optically active form of ofloxacin having (S)-configuration; an inhibitor of bacterial topoisomerase IV and DNA gyrase.	7.46	36	1	9-fluoro-3-methyl-10-(4-methylpiperazin-1-yl)-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid; fluoroquinolone antibiotic; quinolone antibiotic	antibacterial drug; DNA synthesis inhibitor; EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor; topoisomerase IV inhibitor
ezetimibe Ezetimibe: An azetidine derivative and ANTICHOLESTEREMIC AGENT that inhibits intestinal STEROL absorption. It is used to reduce total CHOLESTEROL; LDL CHOLESTEROL, and APOLIPOPROTEINS B in the treatment of HYPERLIPIDEMIAS.. ezetimibe : A beta-lactam that is azetidin-2-one which is substituted at 1, 3, and 4 by p-fluorophenyl, 3-(p-fluorophenyl)-3-hydroxypropyl, and 4-hydroxyphenyl groups, respectively (the 3R,3'S,4S enantiomer).	3.23	1	0	azetidines; beta-lactam; organofluorine compound	anticholesteremic drug; antilipemic drug; antimetabolite
ertapenem Ertapenem: A carbapenem derivative antibacterial agent that is more stable to renal dehydropeptidase I than IMIPENEM, but does not need to be given with an enzyme inhibitor such as CILASTATIN. It is used in the treatment of Gram-positive and Gram-negative bacterial infections including intra-abdominal infections, acute gynecological infections, complicated urinary tract infections, skin infections, and respiratory tract infections. It is also used to prevent infection in colorectal surgery.. ertapenem : Meropenem in which the one of the two methyl groups attached to the amide nitrogen is replaced by hydrogen while the other is replaced by a 3-carboxyphenyl group. The sodium salt is used for the treatment of moderate to severe susceptible infections including intra-abdominal and acute gynaecological infections, pneumonia, and infections of the skin and of the urinary tract.	4.69	8	0	carbapenemcarboxylic acid; pyrrolidinecarboxamide	antibacterial drug
prolylarginine prolylarginine: fragment of tuftsin peptide with analgesic action; RN given refers to all L-isomer. Pro-Arg : A dipeptide formed from L-proline and L-arginine residues.	2.02	1	0	dipeptide	metabolite
dx 8951 [no description available]	2.04	1	0	pyranoindolizinoquinoline
cox 189 lumiracoxib: a COX-2 inhibitor. lumiracoxib : An amino acid that is phenylacetic acid which is substituted at position 2 by the nitrogen of 2-chloro-6-fluoroaniline and at position 5 by a methyl group. A highly selective cyclooxygenase 2 inhibitor, it was briefly used for the treatment of osteoarthritis, but was withdrawn due to concersns of hepatotoxicity.	3.23	1	0	amino acid; monocarboxylic acid; organochlorine compound; organofluorine compound; secondary amino compound	cyclooxygenase 2 inhibitor; non-steroidal anti-inflammatory drug
cilomilast [no description available]	2.45	2	0	methoxybenzenes
conivaptan conivaptan : The amide resulting from the formal condensation of 4-[(biphenyl-2-ylcarbonyl)amino]benzoic acid with the benzazepine nitrogen of 2-methyl-1,4,5,6-tetrahydroimidazo[4,5-d][1]benzazepine. It is an antagonist for two of the three types of arginine vasopressin (AVP) receptors, V1a and V2. It is used as its hydrochloride salt for the treatment of hyponatraemia (low blood sodium levels) caused by syndrome of inappropriate antidiuretic hormone (SIADH).	3.58	2	0	benzazepine	aquaretic; vasopressin receptor antagonist
tezosentan tezosentan: structure in first source	2.04	1	0
sabarubicin sabarubicin: structure given in first source	2.04	1	0
damvar damvar: structure	2.04	1	0
moxifloxacin Moxifloxacin: A fluoroquinolone that acts as an inhibitor of DNA TOPOISOMERASE II and is used as a broad-spectrum antibacterial agent.. moxifloxacin : A quinolone that consists of 4-oxo-1,4-dihydroquinoline-3-carboxylic acid bearing a cyclopropyl substituent at position 1, a fluoro substitiuent at position 6, a (4aS,7aS)-octahydro-6H-pyrrolo[3,4-b]pyridin-6-yl group at position 7 and a methoxy substituent at position 8. A member of the fluoroquinolone class of antibacterial agents.	5.58	21	0	aromatic ether; cyclopropanes; fluoroquinolone antibiotic; pyrrolidinopiperidine; quinolinemonocarboxylic acid; quinolone antibiotic; quinolone	antibacterial drug
pralnacasan pralnacasan: NSAID, ICE inhibitor & metastasis inhibitor; RN & structure in first source	3.23	1	0
clevidipine clevidipine: a calcium channel blocker and antihypertensive agent; structure in first source	3.58	2	0	dihydropyridine
solifenacin [no description available]	3.85	3	0	isoquinolines
dexmethylphenidate dexmethylphenidate : A methyl phenyl(piperidin-2-yl)acetate in which both stereocentres have R configuration. It is the active enantiomer in the racemic drug methylphenidate.	3.23	1	0	methyl phenyl(piperidin-2-yl)acetate	adrenergic agent
xamoterol Xamoterol: A phenoxypropanolamine derivative that is a selective beta-1-adrenergic agonist.	2.72	3	0	morpholines
naproxen Naproxen: An anti-inflammatory agent with analgesic and antipyretic properties. Both the acid and its sodium salt are used in the treatment of rheumatoid arthritis and other rheumatic or musculoskeletal disorders, dysmenorrhea, and acute gout.. naproxen : A methoxynaphthalene that is 2-methoxynaphthalene substituted by a carboxy ethyl group at position 6. Naproxen is a non-steroidal anti-inflammatory drug commonly used for the reduction of pain, fever, inflammation and stiffness caused by conditions such as osteoarthritis, kidney stones, rheumatoid arthritis, psoriatic arthritis, gout, ankylosing spondylitis, menstrual cramps, tendinitis, bursitis, and for the treatment of primary dysmenorrhea. It works by inhibiting both the COX-1 and COX-2 enzymes.	3.54	2	0	methoxynaphthalene; monocarboxylic acid	antipyretic; cyclooxygenase 1 inhibitor; cyclooxygenase 2 inhibitor; drug allergen; environmental contaminant; gout suppressant; non-narcotic analgesic; non-steroidal anti-inflammatory drug; xenobiotic
cinacalcet cinacalcet : A secondary amino compound that is (1R)-1-(naphthalen-1-yl)ethanamine in which one of the hydrogens attached to the nitrogen is substituted by a 3-[3-(trifluoromethyl)phenyl]propyl group.	3.23	1	0	(trifluoromethyl)benzenes; naphthalenes; secondary amino compound	calcimimetic; P450 inhibitor
pirlimycin pirlimycin: RN given refers to (mono-HCl(2S-cis)-isomer)	2.46	2	0
lubiprostone [no description available]	3.23	1	0
telbivudine [no description available]	3.23	1	0	pyrimidine 2'-deoxyribonucleoside	antiviral drug; EC 2.7.7.49 (RNA-directed DNA polymerase) inhibitor
cannabidiolic acid cannabidiolic acid: structure. cannabidiolic acid : A dihydroxybenzoic acid that is olivetolic acid in which the hydrogen at position 3 is substituted by a 3-p-mentha-1,8-dien-3-yl (limonene) group.	2.04	1	0	dihydroxybenzoic acid; phytocannabinoid; polyketide; resorcinols
benzo-tepa benzo-tepa: structure	2.04	1	0
tevenel tevenel: sulfamoyl analog of D-threo-chloramphenicol; structure	2.04	1	0	sulfonamide
tac 278 TAC 278: prodrug of 5-fluorouracil; RN given refers to cpd with unspecified isomeric designation	2.04	1	0
abanoquil [no description available]	2.04	1	0
cannabidiol-3-monomethyl ether cannabidiol-3-monomethyl ether: RN given refers to (1R-trans)-isomer	2.04	1	0
paromomycin Paromomycin: An aminoglycoside antibacterial and antiprotozoal agent produced by species of STREPTOMYCES.. paromomycin : An amino cyclitol glycoside that is the 1-O-(2-amino-2-deoxy-alpha-D-glucopyranoside) and the 3-O-(2,6-diamino-2,6-dideoxy-beta-L-idopyranosyl)-beta-D-ribofuranoside of 4,6-diamino-2,3-dihydroxycyclohexane (the 1R,2R,3S,4R,6S diastereoisomer). It is obtained from various Streptomyces species. A broad-spectrum antibiotic, it is used (generally as the sulfate salt) for the treatment of acute and chronic intestinal protozoal infections, but is not effective for extraintestinal protozoal infections. It is also used as a therapeutic against visceral leishmaniasis.	4.66	5	0	amino cyclitol glycoside; aminoglycoside antibiotic	anthelminthic drug; antibacterial drug; antiparasitic agent; antiprotozoal drug
anidulafungin Anidulafungin: Echinocandin antifungal agent that is used in the treatment of CANDIDEMIA and CANDIDIASIS.. anidulafungin : A semisynthetic echinocandin anti-fungal drug. It is active against Aspergillus and Candida species and is used for the treatment of invasive candidiasis.	3.58	2	0	antibiotic antifungal drug; azamacrocycle; echinocandin; heterodetic cyclic peptide; semisynthetic derivative
metaperiodate metaperiodate: RN given refers to periodic acid, Na salt; structure. periodate : A monovalent inorganic anion obtained by deprotonation of periodic acid.	1.98	1	0	iodine oxoanion; monovalent inorganic anion
aminopterin Aminopterin: A folic acid derivative used as a rodenticide that has been shown to be teratogenic.	2.04	1	0	dicarboxylic acid	EC 1.5.1.3 (dihydrofolate reductase) inhibitor; mutagen
17 alpha-hydroxyprogesterone caproate 17 alpha-Hydroxyprogesterone Caproate: Hydroxyprogesterone derivative that acts as a PROGESTIN and is used to reduce the risk of recurrent MISCARRIAGE and of PREMATURE BIRTH. It is also used in combination with ESTROGEN in the management of MENSTRUATION DISORDERS.	3.23	1	0	corticosteroid hormone
varenicline Varenicline: A benzazepine derivative that functions as an ALPHA4-BETA2 NICOTINIC RECEPTOR partial agonist. It is used for SMOKING CESSATION.. varenicline : An organic heterotetracyclic compound that acts as a partial agonist for nicotinic cholinergic receptors and is used (in the form of its tartate salt) as an aid to giving up smoking.	3.23	1	0
temocillin temocillin: beta-lactam antibiotic with unusual spectrum of antibacterial activity & exceptional stability to bacterial beta-lactamases; RN given refers to di-Na salt (2S-(2alpha,5alpha,6alpha))-isomer; structure in first source. temocillin : A penicillin compound having a 6alpha-methoxy and 6beta-[2-carboxy(thiophen-3-yl)acetamido side-groups.	2.46	2	0	penicillin
(4r)-3-((2s)-3-mercapto-2-methylpropanoyl)-4- thiazolidinecarboxylic acid [no description available]	2.04	1	0
fiduxosin fiduxosin: fiduxosin (ABT-980) is the (3aR,9bR)-isomer; structure in first source	3.23	1	0
methyl 2-pyridyl disulfide methyl 2-pyridyl disulfide: structure given in first source	2.05	1	0
atropine tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate : A tropane alkaloid that is (1R,5)-8-methyl-8-azabicyclo[3.2.1]octane substituted by a (3-hydroxy-2-phenylpropanoyl)oxy group at position 3.	4.24	5	0
ropivacaine Ropivacaine: An anilide used as a long-acting local anesthetic. It has a differential blocking effect on sensory and motor neurons.. ropivacaine : The piperidinecarboxamide obtained by the formal condensation of N-propylpipecolic acid and 2,6-dimethylaniline.. (S)-ropivacaine : A piperidinecarboxamide-based amide-type local anaesthetic (amide caine) in which (S)-N-propylpipecolic acid and 2,6-dimethylaniline are combined to form the amide bond.	2.04	1	0	piperidinecarboxamide; ropivacaine	local anaesthetic
erlotinib [no description available]	3.23	1	0	aromatic ether; quinazolines; secondary amino compound; terminal acetylenic compound	antineoplastic agent; epidermal growth factor receptor antagonist; protein kinase inhibitor
melagatran [no description available]	2.45	2	0	azetidines; carboxamidine; dicarboxylic acid monoamide; non-proteinogenic alpha-amino acid; secondary amino compound	anticoagulant; EC 3.4.21.5 (thrombin) inhibitor; serine protease inhibitor
cirsimaritin cirsimaritin: has antagonist or partial agonist activity on benzodiazepine receptors. cirsimaritin : A dimethoxyflavone that is flavone substituted by methoxy groups at positions 6 and 7 and hydroxy groups at positions 5 and 4' respectively.	2.25	1	0	dihydroxyflavone; dimethoxyflavone
deflazacort deflazacort: structure	2.04	1	0	corticosteroid hormone
hexestrol diphosphate [no description available]	2.04	1	0
carbocysteine Carbocysteine: A compound formed when iodoacetic acid reacts with sulfhydryl groups in proteins. It has been used as an anti-infective nasal spray with mucolytic and expectorant action.. S-carboxymethyl-L-cysteine : An L-cysteine thioether that is L-cysteine in which the hydrogen of the thiol group has been replaced by a carboxymethyl group.	2.04	1	0	L-cysteine thioether; non-proteinogenic L-alpha-amino acid	mucolytic
etravirine [no description available]	3.23	1	0	aminopyrimidine; aromatic ether; dinitrile; organobromine compound	antiviral agent; HIV-1 reverse transcriptase inhibitor
prolylglutamic acid Pro-Glu : A dipeptide formed from L-proline and L-glutamic acid residues.	2.44	2	0	dipeptide	metabolite
troleandomycin Troleandomycin: A macrolide antibiotic that is similar to ERYTHROMYCIN.. troleandomycin : A semi-synthetic macrolide antibiotic obtained by acetylation of the three free hydroxy groups of oleandomycin. Troleandomycin is only found in individuals that have taken the drug.	3.03	1	0	acetate ester; epoxide; macrolide antibiotic; monosaccharide derivative; polyketide; semisynthetic derivative	EC 1.14.13.97 (taurochenodeoxycholate 6alpha-hydroxylase) inhibitor; xenobiotic
dronedarone Dronedarone: A non-iodinated derivative of amiodarone that is used for the treatment of ARRHYTHMIA.. dronedarone : A member of the class of 1-benzofurans used for the treatment of cardiac arrhythmias.	3.23	1	0	1-benzofurans; aromatic ether; aromatic ketone; sulfonamide; tertiary amino compound	anti-arrhythmia drug; environmental contaminant; xenobiotic
tesaglitazar tesaglitazar: structure in first source	2.45	2	0
ramelteon ramelteon: melatonin MT1/MT2 receptor agonist	3.23	1	0	indanes
lapatinib [no description available]	3.23	1	0	furans; organochlorine compound; organofluorine compound; quinazolines	antineoplastic agent; tyrosine kinase inhibitor
darunavir Darunavir: An HIV PROTEASE INHIBITOR that is used in the treatment of AIDS and HIV INFECTIONS. Due to the emergence of ANTIVIRAL DRUG RESISTANCE when used alone, it is administered in combination with other ANTI-HIV AGENTS.. darunavir : An N,N-disubstituted benzenesulfonamide bearing an unsubstituted amino group at the 4-position, used for the treatment of HIV infection. A second-generation HIV protease inhibitor, darunavir was designed to form robust interactions with the protease enzyme from many strains of HIV, including those from treatment-experienced patients with multiple resistance mutations to other protease inhibitors.	3.23	1	0	carbamate ester; furofuran; sulfonamide	antiviral drug; HIV protease inhibitor
iclaprim iclaprim: has antiviral activity. iclaprim : A racemate consisting of equimolar amounts of (R)- and (S)-iclaprim. Both enantiomers exhibit similar, potent bactericidal activity against major Gram-positive pathogens, notably methicillin-sensitive and -resistant Staphylococcus aureus (MSSA and MRSA, respectively).. 5-[(2-cyclopropyl-7,8-dimethoxy-2H-chromen-5-yl)methyl]pyrimidine-2,4-diamine : An aminopyrimidine that is 5-methylpyrimidine-2,4-diamine in which one of the hydrogens of the methyl group has been replaced by a 2-cyclopropyl-7,8-dimethoxy-2H-chromen-5-yl group.	2.05	1	0	aminopyrimidine; chromenes; cyclopropanes
deferasirox Deferasirox: A triazole and benzoate derivative that acts as a selective iron chelator. It is used in the management of chronic IRON OVERLOAD due to blood transfusion or non-transfusion dependent THALASSEMIA.. deferasirox : A member of the class of triazoles, deferasirox is 1,2,4-triazole substituted by a 4-carboxyphenyl group at position 1 and by 2-hydroxyphenyl groups at positions 3 and 5. An orally active iron chelator, it is used to manage chronic iron overload in patients receiving long-term blood transfusions.	3.23	1	0	benzoic acids; monocarboxylic acid; phenols; triazoles	iron chelator
bms204352 BMS204352: a calcium-sensitive opener of maxi-K potassium channels; structure in first source	2.04	1	0
fosfluconazole fosfluconazole: prodrug of fluconazole	2.04	1	0	conazole antifungal drug; triazole antifungal drug; triazoles	prodrug
tbc-11251 sitaxsentan: endothelin A receptor antagonist; structure in first source	3.23	1	0	benzodioxoles
tolvaptan [no description available]	3.23	1	0	benzazepine; benzenedicarboxamide	aquaretic; vasopressin receptor antagonist
sorafenib [no description available]	3.23	1	0	(trifluoromethyl)benzenes; aromatic ether; monochlorobenzenes; phenylureas; pyridinecarboxamide	angiogenesis inhibitor; anticoronaviral agent; antineoplastic agent; EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor; ferroptosis inducer; tyrosine kinase inhibitor
lenalidomide [no description available]	3.23	1	0	aromatic amine; dicarboximide; isoindoles; piperidones	angiogenesis inhibitor; antineoplastic agent; immunomodulator
regadenoson [no description available]	3.23	1	0	purine nucleoside
lacosamide Lacosamide: An acetamide derivative that acts as a blocker of VOLTAGE-GATED SODIUM CHANNELS. It is used as an anticonvulsant, for adjunctive or monotherapy, in the treatment of PARTIAL SEIZURES.	3.23	1	0	N-acyl-amino acid
cp 101,606 traxoprodil mesylate: a selective NMDA antagonist; structure given in first source	2.45	2	0
demecolcine Demecolcine: An alkaloid isolated from Colchicum autumnale L. and used as an antineoplastic.. (-)-demecolcine : A secondary amino compound that is (S)-colchicine in which the N-acetyl group is replaced by an N-methyl group. Isolable from the autumn crocus, Colchicum autumnale, it is less toxic than colchicine and is used as an antineoplastic.	2.04	1	0	alkaloid; secondary amino compound	antineoplastic agent; microtubule-destabilising agent
deoxycholic acid Deoxycholic Acid: A bile acid formed by bacterial action from cholate. It is usually conjugated with glycine or taurine. Deoxycholic acid acts as a detergent to solubilize fats for intestinal absorption, is reabsorbed itself, and is used as a choleretic and detergent.. deoxycholic acid : A bile acid that is 5beta-cholan-24-oic acid substituted by hydroxy groups at positions 3 and 12 respectively.	2.05	1	0	bile acid; C24-steroid; dihydroxy-5beta-cholanic acid	human blood serum metabolite
cortisone [no description available]	2.35	2	0	11-oxo steroid; 17alpha-hydroxy steroid; 20-oxo steroid; 21-hydroxy steroid; 3-oxo-Delta(4) steroid; C21-steroid; glucocorticoid; primary alpha-hydroxy ketone; tertiary alpha-hydroxy ketone	human metabolite; mouse metabolite
3,6-dichlorocarbazole 3,6-dichlorocarbazole: from Bavarian soil; structure in first source	2.41	1	0
vincaleukoblastine [no description available]	3.23	1	0	acetate ester; indole alkaloid fundamental parent; methyl ester; organic heteropentacyclic compound; organic heterotetracyclic compound; tertiary alcohol; tertiary amino compound; vinca alkaloid	antineoplastic agent; immunosuppressive agent; microtubule-destabilising agent; plant metabolite
benzofurans Benzofurans: Compounds that contain a BENZENE ring fused to a furan ring.	2.48	2	0
benzarone benzarone: antihemorrhagic agent; structure	3.23	1	0	1-benzofurans
nsc-89199 estramustine phosphate : A steroid phosphate which is the 17-O-phospho derivative of estramustine.	2.44	2	0	carbamate ester; organochlorine compound; steroid phosphate
estramustine Estramustine: A nitrogen mustard linked to estradiol, usually as phosphate; used to treat prostatic neoplasms; also has radiation protective properties.. estramustine : A carbamate ester obtained by the formal condensation of the hydroxy group of 17beta-estradiol with the carboxy group of bis(2-chloroethyl)carbamic acid.	3.58	2	0	17beta-hydroxy steroid; carbamate ester; organochlorine compound	alkylating agent; antineoplastic agent; radiation protective agent
phenethicillin phenethicillin: minor descriptor (85); major descriptor (63-84); on-line search PENICILLIN, PHENOXYMETHYL/AA (66-85); Index Medicus search PHENETHICILLIN (63-84); RN given refers to (2S-(2alpha,5alpha,6beta))-isomer. phenethicillin : A penicillin in which the substituent at position 6 of the penam ring is a 2-phenoxypropanamido group.	5.9	14	0	penicillin allergen; penicillin
indicine-n-oxide indicine-N-oxide: RN given refers to (1R-(1alpha,7(2R,3S),7abeta))-isomer; structure	2.04	1	0
acivicin [no description available]	2.04	1	0	isoxazoles; non-proteinogenic L-alpha-amino acid; organochlorine compound	antileishmanial agent; antimetabolite; antimicrobial agent; antineoplastic agent; EC 2.3.2.2 (gamma-glutamyltransferase) inhibitor; glutamine antagonist; metabolite
trimethoprim, sulfamethoxazole drug combination Trimethoprim, Sulfamethoxazole Drug Combination: A drug combination with broad-spectrum antibacterial activity against both gram-positive and gram-negative organisms. It is effective in the treatment of many infections, including PNEUMOCYSTIS PNEUMONIA in AIDS.. co-trimoxazole : A two-component mixture comprising trimethoprim and sulfamethoxazole.	6.46	23	2
bortezomib [no description available]	3.58	2	0	amino acid amide; L-phenylalanine derivative; pyrazines	antineoplastic agent; antiprotozoal drug; protease inhibitor; proteasome inhibitor
ritonavir Ritonavir: An HIV protease inhibitor that works by interfering with the reproductive cycle of HIV. It also inhibits CYTOCHROME P-450 CYP3A.. ritonavir : An L-valine derivative that is L-valinamide in which alpha-amino group has been acylated by a [(2-isopropyl-1,3-thiazol-4-yl)methyl]methylcarbamoyl group and in which a hydrogen of the carboxamide amino group has been replaced by a (2R,4S,5S)-4-hydroxy-1,6-diphenyl-5-{[(1,3-thiazol-5-ylmethoxy)carbonyl]amino}hexan-2-yl group. A CYP3A inhibitor and antiretroviral drug from the protease inhibitor class used to treat HIV infection and AIDS, it is often used as a fixed-dose combination with another protease inhibitor, lopinavir. Also used in combination with dasabuvir sodium hydrate, ombitasvir and paritaprevir (under the trade name Viekira Pak) for treatment of chronic hepatitis C virus genotype 1 infection as well as cirrhosis of the liver.	3.23	1	0	1,3-thiazoles; carbamate ester; carboxamide; L-valine derivative; ureas	antiviral drug; environmental contaminant; HIV protease inhibitor; xenobiotic
lanatosides Lanatosides: Glycosides from DIGITALIS lanata leaf. Lanatoside C has actions similar to DIGOXIN. Mixtures of lanatosides A, B, and C have also been used. (From Martindale, The Extra Pharmacopoeia, 30th ed, p670)	1.94	1	0
povidone-iodine Povidone-Iodine: An iodinated polyvinyl polymer used as topical antiseptic in surgery and for skin and mucous membrane infections, also as aerosol. The iodine may be radiolabeled for research purposes.	2.37	2	0
rimiterol rimiterol: was heading 1977-94 (see under CATECHOLS 1977-90); use CATECHOLS to search RIMITEROL 1977-94; predominantly a beta 2 stimulant, therefore affects the cardiovascular system less than isoproterenol, but its action is of shorter duration than that of albuterol	2	1	0	catechols
mbx 1066 MBX 1066: structure in first source	2.05	1	0
glycogen glycogen : A polydisperse, highly branched glucan composed of chains of D-glucopyranose residues in alpha(1->4) glycosidic linkage, joined together by alpha(1->6) glycosidic linkages. A small number of alpha(1->3) glycosidic linkages and some cumulative alpha(1->6) links also may occur. The branches in glycogen typically contain 8 to 12 glucose residues.	1.95	1	0
fibrin Fibrin: A protein derived from FIBRINOGEN in the presence of THROMBIN, which forms part of the blood clot.	8.05	5	0	peptide
oxytocin Oxytocin: A nonapeptide hormone released from the neurohypophysis (PITUITARY GLAND, POSTERIOR). It differs from VASOPRESSIN by two amino acids at residues 3 and 8. Oxytocin acts on SMOOTH MUSCLE CELLS, such as causing UTERINE CONTRACTIONS and MILK EJECTION.. oxytocin : A cyclic nonapeptide hormone with amino acid sequence CYIQNCPLG that also acts as a neurotransmitter in the brain; the principal uterine-contracting and milk-ejecting hormone of the posterior pituitary. Together with the neuropeptide vasopressin, it is believed to influence social cognition and behaviour.	3.8	3	0	heterodetic cyclic peptide; peptide hormone	oxytocic; vasodilator agent
cysteinylglycine cysteinylglycine: RN given refers to (L)-isomer; RN for cpd without isomeric designation not in Chemlne 7/13/83. L-cysteinylglycine : A dipeptide consisting of glycine having an L-cysteinyl attached to its alpha-amino group. It is an intermediate metabolite in glutathione metabolism.	2.44	2	0	dipeptide zwitterion; dipeptide	Escherichia coli metabolite; human metabolite; Saccharomyces cerevisiae metabolite
pentostatin Pentostatin: A potent inhibitor of ADENOSINE DEAMINASE. The drug induces APOPTOSIS of LYMPHOCYTES, and is used in the treatment of many lymphoproliferative malignancies, particularly HAIRY CELL LEUKEMIA. It is also synergistic with some other antineoplastic agents and has immunosuppressive activity.. pentostatin : A member of the class of coformycins that is coformycin in which the hydroxy group at position 2' is replaced with a hydrogen. It is a drug used for the treatment of hairy cell leukaemia.	3.58	2	0	coformycins	antimetabolite; antineoplastic agent; Aspergillus metabolite; bacterial metabolite; EC 3.5.4.4 (adenosine deaminase) inhibitor
quinidine Quinidine: An optical isomer of quinine, extracted from the bark of the CHINCHONA tree and similar plant species. This alkaloid dampens the excitability of cardiac and skeletal muscles by blocking sodium and potassium currents across cellular membranes. It prolongs cellular ACTION POTENTIALS, and decreases automaticity. Quinidine also blocks muscarinic and alpha-adrenergic neurotransmission.. quinidine : A cinchona alkaloid consisting of cinchonine with the hydrogen at the 6-position of the quinoline ring substituted by methoxy.	4.06	4	0	cinchona alkaloid	alpha-adrenergic antagonist; anti-arrhythmia drug; antimalarial; drug allergen; EC 1.14.13.181 (13-deoxydaunorubicin hydroxylase) inhibitor; EC 3.6.3.44 (xenobiotic-transporting ATPase) inhibitor; muscarinic antagonist; P450 inhibitor; potassium channel blocker; sodium channel blocker
meropenem Meropenem: A thienamycin derivative antibacterial agent that is more stable to renal dehydropeptidase I than IMIPENEM, but does not need to be given with an enzyme inhibitor such as CILASTATIN. It is used in the treatment of bacterial infections, including infections in immunocompromised patients.. meropenem : A carbapenemcarboxylic acid in which the azetidine and pyrroline rings carry 1-hydroxymethyl and in which the azetidine and pyrroline rings carry 1-hydroxymethyl and 5-(dimethylcarbamoyl)pyrrolidin-3-ylthio substituents respectively.	7.75	28	1	alpha,beta-unsaturated monocarboxylic acid; carbapenemcarboxylic acid; organic sulfide; pyrrolidinecarboxamide	antibacterial agent; antibacterial drug; drug allergen
griseofulvin Griseofulvin: An antifungal agent used in the treatment of TINEA infections.. griseofulvin : An oxaspiro compound produced by Penicillium griseofulvum. It is used by mouth as an antifungal drug for infections involving the scalp, hair, nails and skin that do not respond to topical treatment.	3.99	2	0	1-benzofurans; antibiotic antifungal drug; benzofuran antifungal drug; organochlorine compound; oxaspiro compound	antibacterial agent; Penicillium metabolite
cefoxitin Cefoxitin: A semisynthetic cephamycin antibiotic resistant to beta-lactamase.. cefoxitin : A semisynthetic cephamycin antibiotic which, in addition to the methoxy group at the 7alpha position, has 2-thienylacetamido and carbamoyloxymethyl side-groups. It is resistant to beta-lactamase.	8.81	140	1	beta-lactam antibiotic allergen; cephalosporin; cephamycin; semisynthetic derivative	antibacterial drug
digitoxin Digitoxin: A cardiac glycoside sometimes used in place of DIGOXIN. It has a longer half-life than digoxin; toxic effects, which are similar to those of digoxin, are longer lasting. (From Martindale, The Extra Pharmacopoeia, 30th ed, p665). digitoxin : A cardenolide glycoside in which the 3beta-hydroxy group of digitoxigenin carries a 2,6-dideoxy-beta-D-ribo-hexopyranosyl-(1->4)-2,6-dideoxy-beta-D-ribo-hexopyranosyl-(1->4)-2,6-dideoxy-beta-D-ribo-hexopyranosyl trisaccharide chain.	2.69	3	0	cardenolide glycoside	EC 3.6.3.9 (Na(+)/K(+)-transporting ATPase) inhibitor
moxalactam disodium [no description available]	2.07	1	0
saquinavir Saquinavir: An HIV protease inhibitor which acts as an analog of an HIV protease cleavage site. It is a highly specific inhibitor of HIV-1 and HIV-2 proteases, and also inhibits CYTOCHROME P-450 CYP3A.. saquinavir : An aspartic acid derivative obtained by formal condensation of the primary amino group of (2S,3R)-4-[(3S,4aS,8aS)-3-(tert-butylcarbamoyl)octahydroisoquinolin-2(1H)-yl]-3-hydroxy-1-phenylbutan-2-ylamine with the carboxy group of N(2)(-quinolin-2-ylcarbonyl)-L-asparagine. An inhibitor of HIV-1 protease.	3.58	2	0	L-asparagine derivative; quinolines	antiviral drug; HIV protease inhibitor
pancuronium Pancuronium: A bis-quaternary steroid that is a competitive nicotinic antagonist. As a neuromuscular blocking agent it is more potent than CURARE but has less effect on the circulatory system and on histamine release.. pancuronium : A steroid ester in which a 5alpha-androstane skeleton is C-3alpha- and C-17beta-disubstituted with acetoxy groups and 2beta- and 16beta-disubstituted with 1-methylpiperidinium-1-yl groups. It is a non-depolarizing curare-mimetic muscle relaxant.	3.58	2	0	acetate ester; steroid ester	cholinergic antagonist; muscle relaxant; nicotinic antagonist
rocuronium Rocuronium: An androstanol non-depolarizing neuromuscular blocking agent. It has a mono-quaternary structure and is a weaker nicotinic antagonist than PANCURONIUM.. rocuronium : A 5alpha-androstane compound having 3alpha-hydroxy-, 17beta-acetoxy-, 2beta-morpholino- and 16beta-N-allyllyrrolidinium substituents.	2.04	1	0	3alpha-hydroxy steroid; acetate ester; androstane; morpholines; quaternary ammonium ion; tertiary amino compound	drug allergen; muscle relaxant; neuromuscular agent
abacavir abacavir: a carbocyclic nucleoside with potent selective anti-HIV activity. abacavir : A 2,6-diaminopurine that is (1S)-cyclopent-2-en-1-ylmethanol in which the pro-R hydrogen at the 4-position is substituted by a 2-amino-6-(cyclopropylamino)-9H-purin-9-yl group. A nucleoside analogue reverse transcriptase inhibitor (NRTI) with antiretroviral activity against HIV, it is used (particularly as the sulfate) with other antiretrovirals in combination therapy of HIV infection.	3.85	3	0	2,6-diaminopurines	antiviral drug; drug allergen; HIV-1 reverse transcriptase inhibitor
netilmicin Netilmicin: Semisynthetic 1-N-ethyl derivative of SISOMYCIN, an aminoglycoside antibiotic with action similar to gentamicin, but less ear and kidney toxicity.	3.6	9	0
miglitol [no description available]	3.85	3	0	piperidines
7-aminocephalosporanic acid 7beta-aminocephalosporanic acid : The alpha,beta-unsaturated monocarboxylic acid that is the active nucleus for the synthesis of cephalosporins and intermediates.	2.02	1	0	alpha,beta-unsaturated monocarboxylic acid; amino acid zwitterion
metyrosine alpha-methyl-L-tyrosine : An L-tyrosine derivative that consists of L-tyrosine bearing an additional methyl substituent at position 2. An inhibitor of the enzyme tyrosine 3-monooxygenase, and consequently of the synthesis of catecholamines. It is used to control the symptoms of excessive sympathetic stimulation in patients with pheochromocytoma.	3.23	1	0	L-tyrosine derivative; non-proteinogenic L-alpha-amino acid	antihypertensive agent; EC 1.14.16.2 (tyrosine 3-monooxygenase) inhibitor
bacampicillin bacampicillin: ester prodrug that is hydrolyzed to ampicillin after its absorption from the gastrointestinal tract; RN given refers to parent cpd; structure. bacampicillin : A penicillanic acid ester that is the 1-ethoxycarbonyloxyethyl ester of ampicillin. It is a semi-synthetic, microbiologically inactive prodrug of ampicillin.	2.04	1	0	penicillanic acid ester	prodrug
linezolid [no description available]	9.13	66	2	acetamides; morpholines; organofluorine compound; oxazolidinone	antibacterial drug; protein synthesis inhibitor
angustibalin angustibalin: sesquiterpene lactone from Balduina angustifolia (Pursh) Robins; structure	2.04	1	0	sesquiterpene lactone
casuarinin casuarinin: a hydrolyzable tannin from the bark of Terminalia arjuna (Combretaceae)	2.15	1	0	tannin
tellimagrandin i tellimagrandin I: isolated from Filipendula palmata; RN given for (D)-isomer	2.02	1	0	tannin
lignans Lignans: A class of dibenzylbutane derivatives which occurs in higher plants and in fluids (bile, serum, urine, etc.) in man and other animals. These compounds, which have a potential anti-cancer role, can be synthesized in vitro by human fecal flora. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed)	2.11	1	0
phenylalanine arginine beta-naphthylamide phenylalanine arginine beta-naphthylamide: a drug efflux pump inhibitor; structure in first source	2.52	2	0	peptide
clindamycin phosphate [no description available]	3.23	1	0
eplerenone Eplerenone: A spironolactone derivative and selective ALDOSTERONE RECEPTOR antagonist that is used in the management of HYPERTENSION and CONGESTIVE HEART FAILURE, post-MYOCARDIAL INFARCTION.	3.23	1	0	3-oxo-Delta(4) steroid; epoxy steroid; gamma-lactone; methyl ester; organic heteropentacyclic compound; oxaspiro compound; steroid acid ester	aldosterone antagonist; antihypertensive agent
tolterodine [no description available]	3.85	3	0	tertiary amine	antispasmodic drug; muscarinic antagonist; muscle relaxant
metrizamide Metrizamide: A solute for density gradient centrifugation offering higher maximum solution density without the problems of increased viscosity. It is also used as a resorbable, non-ionic contrast medium.	2.04	1	0	amino sugar
dironyl dironyl: pronounced antifertility agent in rats; lactation suppressor in other species; serotonin antagonist; RN given refers to parent cpd; structure	2	1	0	organic molecular entity
erythromycin ethylsuccinate Erythromycin Ethylsuccinate: A macrolide antibiotic, produced by Streptomyces erythreus. This compound is an ester of erythromycin base and succinic acid. It acts primarily as a bacteriostatic agent. In sensitive organisms, it inhibits protein synthesis by binding to 50S ribosomal subunits. This binding process inhibits peptidyl transferase activity and interferes with translocation of amino acids during translation and assembly of proteins.. erythromycin ethylsuccinate : A erythromycin derivative that is erythromycin A in which the hydroxy group at position 3R is substituted by a (4-ethoxy-4-oxobutanoyl)oxy group. It is used for the treatment of a wide variety of bacterial infections.	4.29	20	0	cyclic ketone; erythromycin derivative; ethyl ester; succinate ester
sultamicillin sultamicillin: contains ampicillin & sulbactam	2.9	4	0	penicillanic acid ester
darifenacin darifenacin : 2-[(3S)-1-Ethylpyrrolidin-3-yl]-2,2-diphenylacetamide in which one of the hydrogens at the 2-position of the ethyl group is substituted by a 2,3-dihydro-1-benzofuran-5-yl group. It is a selective antagonist for the M3 muscarinic acetylcholine receptor, which is primarily responsible for bladder muscle contractions, and is used as the hydrobromide salt in the management of urinary incontinence.	3.58	2	0	1-benzofurans; monocarboxylic acid amide; pyrrolidines	antispasmodic drug; muscarinic antagonist
fluticasone propionate fluticasone propionate : A trifluorinated corticosteroid that consists of 6alpha,9-difluoro-11beta,17alpha-dihydroxy-17beta-{[(fluoromethyl)sulfanyl]carbonyl}-16-methyl-3-oxoandrosta-1,4-diene bearing a propionyl substituent at position 17; has anti-inflammatory, anti-asthmatic and anti-allergic activity.	2.04	1	0	11beta-hydroxy steroid; 3-oxo-Delta(1),Delta(4)-steroid; corticosteroid; fluorinated steroid; propanoate ester; steroid ester; thioester	adrenergic agent; anti-allergic agent; anti-asthmatic drug; anti-inflammatory drug; bronchodilator agent; dermatologic drug
betadex beta-Cyclodextrins: Cyclic GLUCANS consisting of seven (7) glucopyranose units linked by 1,4-glycosidic bonds.	2.01	1	0	cyclodextrin
acarbose [no description available]	2.04	1	0	amino cyclitol; glycoside
tretinoin Tretinoin: An important regulator of GENE EXPRESSION during growth and development, and in NEOPLASMS. Tretinoin, also known as retinoic acid and derived from maternal VITAMIN A, is essential for normal GROWTH; and EMBRYONIC DEVELOPMENT. An excess of tretinoin can be teratogenic. It is used in the treatment of PSORIASIS; ACNE VULGARIS; and several other SKIN DISEASES. It has also been approved for use in promyelocytic leukemia (LEUKEMIA, PROMYELOCYTIC, ACUTE).. retinoic acid : A retinoid consisting of 3,7-dimethylnona-2,4,6,8-tetraenoic acid substituted at position 9 by a 2,6,6-trimethylcyclohex-1-en-1-yl group (geometry of the four exocyclic double bonds is not specified).. all-trans-retinoic acid : A retinoic acid in which all four exocyclic double bonds have E- (trans-) geometry.	3.54	2	0	retinoic acid; vitamin A	anti-inflammatory agent; antineoplastic agent; antioxidant; AP-1 antagonist; human metabolite; keratolytic drug; retinoic acid receptor agonist; retinoid X receptor agonist; signalling molecule
farnesol Farnesol: A colorless liquid extracted from oils of plants such as citronella, neroli, cyclamen, and tuberose. It is an intermediate step in the biological synthesis of cholesterol from mevalonic acid in vertebrates. It has a delicate odor and is used in perfumery. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed). (2-trans,6-trans)-farnesol : The (2-trans,6-trans)-stereoisomer of farnesol.. farnesol : A farnesane sesquiterpenoid that is dodeca-2,6,10-triene substituted by methyl groups at positions 3, 7 and 11 and a hydroxy group at position 1.	2.63	2	0	farnesol	plant metabolite
resveratrol trans-resveratrol : A resveratrol in which the double bond has E configuration.	2.46	2	0	resveratrol	antioxidant; phytoalexin; plant metabolite; quorum sensing inhibitor; radical scavenger
retinol Vitamin A: Retinol and derivatives of retinol that play an essential role in metabolic functioning of the retina, the growth of and differentiation of epithelial tissue, the growth of bone, reproduction, and the immune response. Dietary vitamin A is derived from a variety of CAROTENOIDS found in plants. It is enriched in the liver, egg yolks, and the fat component of dairy products.. vitamin A : Any member of a group of fat-soluble retinoids produced via metabolism of provitamin A carotenoids that exhibit biological activity against vitamin A deficiency. Vitamin A is involved in immune function, vision, reproduction, and cellular communication.. all-trans-retinol : A retinol in which all four exocyclic double bonds have E- (trans-) geometry.. retinol : A retinoid consisting of 3,7-dimethylnona-2,4,6,8-tetraen-1-ol substituted at position 9 by a 2,6,6-trimethylcyclohex-1-en-1-yl group (geometry of the four exocyclic double bonds is not specified).	3.58	2	0	retinol; vitamin A	human metabolite; mouse metabolite; plant metabolite
tacrolimus Tacrolimus: A macrolide isolated from the culture broth of a strain of Streptomyces tsukubaensis that has strong immunosuppressive activity in vivo and prevents the activation of T-lymphocytes in response to antigenic or mitogenic stimulation in vitro.. tacrolimus (anhydrous) : A macrolide lactam containing a 23-membered lactone ring, originally isolated from the fermentation broth of a Japanese soil sample that contained the bacteria Streptomyces tsukubaensis.	3.85	3	0	macrolide lactam	bacterial metabolite; immunosuppressive agent
cerivastatin cerivastatin: cerivastatin is the ((E)-(+))-isomer; structure given in first source. cerivastatin : (3R,5S)-3,5-dihydroxyhept-6-enoic acid in which the (7E)-hydrogen is substituted by a 4-(4-fluorophenyl)-2,6-diisopropyl-5-(methoxymethyl)pyridin-3-yl group. Formerly used (as its sodium salt) to lower cholesterol and prevent cardiovascular disease, it was withdrawn from the market worldwide in 2001 following reports of a severe form of muscle toxicity.	2.45	2	0	dihydroxy monocarboxylic acid; pyridines; statin (synthetic)
rosuvastatin rosuvastatin : A dihydroxy monocarboxylic acid that is (6E)-7-{4-(4-fluorophenyl)-2-[methyl(methylsulfonyl)amino]-6-(propan-2-yl)pyrimidin-5-yl} hept-6-enoic acid carrying two hydroxy substituents at positions 3 and 5 (the 3R,5S-diastereomer).	3.85	3	0	dihydroxy monocarboxylic acid; monofluorobenzenes; pyrimidines; statin (synthetic); sulfonamide	anti-inflammatory agent; antilipemic drug; cardioprotective agent; CETP inhibitor; environmental contaminant; xenobiotic
cocaine Cocaine: An alkaloid ester extracted from the leaves of plants including coca. It is a local anesthetic and vasoconstrictor and is clinically used for that purpose, particularly in the eye, ear, nose, and throat. It also has powerful central nervous system effects similar to the amphetamines and is a drug of abuse. Cocaine, like amphetamines, acts by multiple mechanisms on brain catecholaminergic neurons; the mechanism of its reinforcing effects is thought to involve inhibition of dopamine uptake.. cocaine : A tropane alkaloid obtained from leaves of the South American shrub Erythroxylon coca.	4.28	4	1	benzoate ester; methyl ester; tertiary amino compound; tropane alkaloid	adrenergic uptake inhibitor; central nervous system stimulant; dopamine uptake inhibitor; environmental contaminant; local anaesthetic; mouse metabolite; plant metabolite; serotonin uptake inhibitor; sodium channel blocker; sympathomimetic agent; vasoconstrictor agent; xenobiotic
mycophenolic acid Mycophenolic Acid: Compound derived from Penicillium stoloniferum and related species. It blocks de novo biosynthesis of purine nucleotides by inhibition of the enzyme inosine monophosphate dehydrogenase (IMP DEHYDROGENASE). Mycophenolic acid exerts selective effects on the immune system in which it prevents the proliferation of T-CELLS, LYMPHOCYTES, and the formation of antibodies from B-CELLS. It may also inhibit recruitment of LEUKOCYTES to sites of INFLAMMATION.. mycophenolate : A monocarboxylic acid anion resulting from the removal of a proton from the carboxy group of mycophenolic acid.. mycophenolic acid : A member of the class of 2-benzofurans that is 2-benzofuran-1(3H)-one which is substituted at positions 4, 5, 6, and 7 by methyl, methoxy, (2E)-5-carboxy-3-methylpent-2-en-1-yl, and hydroxy groups, respectively. It is an antibiotic produced by Penicillium brevi-compactum, P. stoloniferum, P. echinulatum and related species. An immunosuppressant, it is widely used (partiularly as its sodium salt and as the 2-(morpholin-4-yl)ethyl ester prodrug, mycophenolate mofetil) to prevent tissue rejection following organ transplants and for the treatment of certain autoimmune diseases.	3.58	2	0	2-benzofurans; gamma-lactone; monocarboxylic acid; phenols	anticoronaviral agent; antimicrobial agent; antineoplastic agent; EC 1.1.1.205 (IMP dehydrogenase) inhibitor; environmental contaminant; immunosuppressive agent; mycotoxin; Penicillium metabolite; xenobiotic
mupirocin Mupirocin: A topically used antibiotic from a strain of Pseudomonas fluorescens. It has shown excellent activity against gram-positive staphylococci and streptococci. The antibiotic is used primarily for the treatment of primary and secondary skin disorders, nasal infections, and wound healing.. mupirocin : An alpha,beta-unsaturated ester resulting from the formal condensation of the alcoholic hydroxy group of 9-hydroxynonanoic acid with the carboxy group of (2E)-4-[(2S)-tetrahydro-2H-pyran-2-yl]-3-methylbut-2-enoic acid in which the tetrahydropyranyl ring is substituted at positions 3 and 4 by hydroxy groups and at position 5 by a {(2S,3S)-3-[(2S,3S)-3-hydroxybutan-2-yl]oxiran-2-yl}methyl group. Originally isolated from the Gram-negative bacterium Pseudomonas fluorescens, it is used as a topical antibiotic for the treatment of Gram-positive bacterial infections.	4.26	17	0	alpha,beta-unsaturated carboxylic ester; epoxide; monocarboxylic acid; oxanes; secondary alcohol; triol	antibacterial drug; bacterial metabolite; protein synthesis inhibitor
clindamycin Clindamycin: An antibacterial agent that is a semisynthetic analog of LINCOMYCIN.. clindamycin : A carbohydrate-containing antibiotic that is the semisynthetic derivative of lincomycin, a natural antibiotic.	11.07	104	4
fosfomycin Fosfomycin: An antibiotic produced by Streptomyces fradiae.. fosfomycin : A phosphonic acid having an (R,S)-1,2-epoxypropyl group attached to phosphorus.	7.65	26	2	epoxide; phosphonic acids	antimicrobial agent; EC 2.5.1.7 (UDP-N-acetylglucosamine 1-carboxyvinyltransferase) inhibitor
zithromax Azithromycin: A semi-synthetic macrolide antibiotic structurally related to ERYTHROMYCIN. It has been used in the treatment of Mycobacterium avium intracellulare infections, toxoplasmosis, and cryptosporidiosis.. azithromycin : A macrolide antibiotic useful for the treatment of bacterial infections.	5.21	14	0	macrolide antibiotic	antibacterial drug; environmental contaminant; xenobiotic
formycin [no description available]	2.04	1	0	formycin	antineoplastic agent
bms 214662 7-cyano-2,3,4,5-tetrahydro-1-(1H-imidazol-4-ylmethyl)-3-(phenylmethyl)-4-(2-thienylsulfonyl)-1H-1,4-benzodiazepine: a farnesyltransferase inhibitor; structure in first source. BMS-214662 : A member of the class of benzodiazepines that is 2,3,4,5-tetrahydro-1H-1,4-benzodiazepine substituted by (1H-imidazol-5-yl)methyl, benzyl, (thiophen-2-yl)sulfonyl, and cyano groups at positions 1, 3R, 4 and 7, respectively. It is a potent inhibitor of farnesyltransferase (IC50 = 1.35nM) which was under clinical development for the treatment of solid tumors.	2.04	1	0	benzenes; benzodiazepine; imidazoles; nitrile; sulfonamide; thiophenes	antineoplastic agent; apoptosis inducer; EC 2.5.1.58 (protein farnesyltransferase) inhibitor
octreotide [no description available]	3.23	1	0
eptifibatide [no description available]	3.58	2	0	homodetic cyclic peptide; macrocycle; organic disulfide	anticoagulant; platelet aggregation inhibitor
gs 4071 GS 4071: The acid form.. oseltamivir acid : A cyclohexenecarboxylic acid that is cyclohex-1-ene-1-carboxylic acid which is substituted at positions 3, 4, and 5 by pentan-3-yloxy, acetamido, and amino groups, respectively (the 3R,4R,5S enantiomer). An antiviral drug, it is used as the corresponding ethyl ester prodrug, oseltamivir, to slow the spread of influenza.	2.45	2	0	acetate ester; amino acid; cyclohexenecarboxylic acid; primary amino compound	antiviral drug; EC 3.2.1.18 (exo-alpha-sialidase) inhibitor; marine xenobiotic metabolite
imidazolidines [no description available]	3.4	1	1	azacycloalkane; imidazolidines; saturated organic heteromonocyclic parent
decitabine [no description available]	3.85	3	0	2'-deoxyribonucleoside
sm 8668 Sch 39304: Sch 42427 is the active entantiomer of the antifungal agent Sch 39304 which consists of Sch 42426 & Sch 42427; Sch 42426, the (S,S)-isomer, is inactive	2.04	1	0
teniposide [no description available]	4.07	4	0	aromatic ether; beta-D-glucoside; cyclic acetal; furonaphthodioxole; gamma-lactone; monosaccharide derivative; phenols; thiophenes	antineoplastic agent; EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor
troxacitabine troxacitabine: shows good anti-HIV activity without cytotoxicity	2.04	1	0	carbohydrate derivative; nucleobase-containing molecular entity
cefamandole Cefamandole: Semisynthetic wide-spectrum cephalosporin with prolonged action, probably due to beta-lactamase resistance. It is used also as the nafate.. cefamandole : A cephalosporin compound having (R)-mandelamido and N-methylthiotetrazole side-groups.	4.47	23	0	cephalosporin; semisynthetic derivative	antibacterial drug
dactinomycin Dactinomycin: A compound composed of a two CYCLIC PEPTIDES attached to a phenoxazine that is derived from STREPTOMYCES parvullus. It binds to DNA and inhibits RNA synthesis (transcription), with chain elongation more sensitive than initiation, termination, or release. As a result of impaired mRNA production, protein synthesis also declines after dactinomycin therapy. (From AMA Drug Evaluations Annual, 1993, p2015)	3.59	2	0	actinomycin	mutagen
tiazofurin tiazofurin: RN given refers to (beta-D)-isomer; structure given in first source. tiazofurine : A C-glycosyl compound that is 1,3-thiazole-4-carboxamide in which the hydrogen at position 2 has been replaced by a beta-D-ribofuranosyl group. It is metabolised to thiazole-4-carboxamide adenine dinucleotide (TAD), a selective inhibitor of inosine monophosphate dehydrogenase (IMP dehydrogenase).	2.44	2	0	1,3-thiazoles; C-glycosyl compound; monocarboxylic acid amide	antineoplastic agent; EC 1.1.1.205 (IMP dehydrogenase) inhibitor; prodrug
azaserine Azaserine: Antibiotic substance produced by various Streptomyces species. It is an inhibitor of enzymatic activities that involve glutamine and is used as an antineoplastic and immunosuppressive agent.. azaserine : A carboxylic ester resulting from the formal condensation of the carboxy group of diazoacetic acid with the alcoholic hydroxy group of L-serine. An antibiotic produced by a Streptomyces species.	2.04	1	0	carboxylic ester; diazo compound; L-serine derivative; non-proteinogenic L-alpha-amino acid	antifungal agent; antimetabolite; antimicrobial agent; antineoplastic agent; glutamine antagonist; immunosuppressive agent; metabolite
melphalan Melphalan: An alkylating nitrogen mustard that is used as an antineoplastic in the form of the levo isomer - MELPHALAN, the racemic mixture - MERPHALAN, and the dextro isomer - MEDPHALAN; toxic to bone marrow, but little vesicant action; potential carcinogen.. melphalan : A phenylalanine derivative comprising L-phenylalanine having [bis(2-chloroethyl)amino group at the 4-position on the phenyl ring.	4.07	4	0	L-phenylalanine derivative; nitrogen mustard; non-proteinogenic L-alpha-amino acid; organochlorine compound	alkylating agent; antineoplastic agent; carcinogenic agent; drug allergen; immunosuppressive agent
sitafloxacin [no description available]	2.45	2	0	fluoroquinolone antibiotic; quinolines; quinolone antibiotic
tenofovir tenofovir (anhydrous) : A member of the class of phosphonic acids that is methylphosphonic acid in which one of the methyl hydrogens is replaced by a [(2R)-1-(6-amino-9H-purin-9-yl)propan-2-yl]oxy group. An inhibitor of HIV-1 reverse transcriptase, the bis(isopropyloxycarbonyloxymethyl) ester (disoproxil ester) prodrug is used as the fumaric acid salt in combination therapy for the treatment of HIV infection.	3.85	3	0	nucleoside analogue; phosphonic acids	antiviral drug; drug metabolite; HIV-1 reverse transcriptase inhibitor
posaconazole [no description available]	3.23	1	0	aromatic ether; conazole antifungal drug; N-arylpiperazine; organofluorine compound; oxolanes; triazole antifungal drug; triazoles	trypanocidal drug
dibekacin Dibekacin: Analog of KANAMYCIN with antitubercular as well as broad-spectrum antimicrobial properties.. dibekacin : A kanamycin that is kanamycin B lacking the 3- and 4-hydroxy groups on the 2,6-diaminosugar ring.	2.96	4	0	kanamycins	antibacterial agent; protein synthesis inhibitor
aspartyl-aspartic acid aspartyl-aspartic acid: do not confuse with cyclo(Asp-Asp). Asp-Asp : A dipeptide formed from two L-aspartic acid units.	2.44	2	0	dipeptide	Mycoplasma genitalium metabolite
micafungin Micafungin: A cyclic lipo-hexapeptide echinocandin antifungal agent that is used for the treatment and prevention of CANDIDIASIS.. micafungin : A cyclic hexapeptide echinocandin antibiotic which exerts its effect by inhibiting the synthesis of 1,3-beta-D-glucan, an integral component of the fungal cell wall. It is used as the sodium salt for the treatment of invasive candidiasis, and of aspergillosis in patients who are intolerant of other therapy.	3.58	2	0	antibiotic antifungal drug; echinocandin	antiinfective agent
shikonin shikonin: a naphthazarin; has antineoplastic and angiogenesis inhibiting activities	2.01	1	0	hydroxy-1,4-naphthoquinone
riboflavin vitamin B2 : Any member of a group of vitamers that belong to the chemical structural class called flavins that exhibit biological activity against vitamin B2 deficiency. Symptoms associated with vitamin B2 deficiency include glossitis, seborrhea, angular stomaitis, cheilosis and photophobia. The vitamers include riboflavin and its phosphate derivatives (and includes their salt, ionised and hydrate forms).	3.23	1	0	flavin; vitamin B2	anti-inflammatory agent; antioxidant; cofactor; Escherichia coli metabolite; food colouring; fundamental metabolite; human urinary metabolite; mouse metabolite; photosensitizing agent; plant metabolite
sodium bicarbonate Sodium Bicarbonate: A white, crystalline powder that is commonly used as a pH buffering agent, an electrolyte replenisher, systemic alkalizer and in topical cleansing solutions.	3.68	2	0	one-carbon compound; organic sodium salt	antacid; food anticaking agent
arsenic trioxide Tetraarsenic Oxide: A form of As2O3 that exists as As4O6 in the solid state. It dissociates to As2O3 upon heating to the vapor phase above 800 degrees Celsius.	3.23	1	0	arsenic oxide	antineoplastic agent; insecticide
dipyrone Dipyrone: A drug that has analgesic, anti-inflammatory, and antipyretic properties. It is the sodium sulfonate of AMINOPYRINE.. metamizole sodium : An organic sodium salt of antipyrine substituted at C-4 by a methyl(sulfonatomethyl)amino group, commonly used as a powerful analgesic and antipyretic.	2.39	2	0	organic sodium salt	anti-inflammatory agent; antipyretic; antirheumatic drug; cyclooxygenase 3 inhibitor; non-narcotic analgesic; peripheral nervous system drug; prodrug
vulgarone b vulgarone B: sesquiterpene ketone antifungal constituent in the steam-distilled fraction of Artemisia douglasiana; structure in first source	7.05	1	0
4-[[bis(2-hydroxyethyl)amino]methyl]-2,6-ditert-butylphenol [no description available]	2.04	1	0	alkylbenzene
aceglatone aceglatone: structure in Merck	2.04	1	0	organic molecular entity
sr 90107 fondaparinux sodium : An organic sodium salt, being the decasodium salt of fondaparinux.	3.23	1	0
carbenoxolone [no description available]	2.04	1	0
meglumine iodipamide [no description available]	3.23	1	0	organoammonium salt	radioopaque medium
glycosides [no description available]	2.66	3	0
isomethyleugenol Methylation: Addition of methyl groups. In histo-chemistry methylation is used to esterify carboxyl groups and remove sulfate groups by treating tissue sections with hot methanol in the presence of hydrochloric acid. (From Stedman, 25th ed)	1.94	1	0	isomethyleugenol
stilbenes Stilbenes: Organic compounds that contain 1,2-diphenylethylene as a functional group.. trans-stilbene : The trans-isomer of stilbene.	2.02	1	0	stilbene
thyrotropin-releasing hormone PR 546: no other info available 9/89. protirelin : A tripeptide composed of L-pyroglutamyl, L-histidyl and L-prolinamide residues joined in sequence.	3.23	1	0	peptide hormone; tripeptide	human metabolite
xanthohumol xanthohumol: from hop plant, Humulus lupulus. xanthohumol : A member of the class of chalcones that is trans-chalcone substituted by hydroxy groups at positions 4, 2' and 4', a methoxy group at position 6' and a prenyl group at position 3'. Isolated from Humulus lupulus, it induces apoptosis in human malignant glioblastoma cells.	2.08	1	0	aromatic ether; chalcones; polyphenol	anti-HIV-1 agent; antineoplastic agent; antiviral agent; apoptosis inducer; EC 2.3.1.20 (diacylglycerol O-acyltransferase) inhibitor; metabolite
cannabidiol Cannabidiol: Compound isolated from Cannabis sativa extract.. cannabidiol : An cannabinoid that is cyclohexene which is substituted by a methyl group at position 1, a 2,6-dihydroxy-4-pentylphenyl group at position 3, and a prop-1-en-2-yl group at position 4.	2.04	1	0	olefinic compound; phytocannabinoid; resorcinols	antimicrobial agent; plant metabolite
arginine vasopressin Arginine Vasopressin: The predominant form of mammalian antidiuretic hormone. It is a nonapeptide containing an ARGININE at residue 8 and two disulfide-linked cysteines at residues of 1 and 6. Arg-vasopressin is used to treat DIABETES INSIPIDUS or to improve vasomotor tone and BLOOD PRESSURE.. argipressin : The predominant form of mammalian vasopressin (antidiuretic hormone). It is a nonapeptide containing an arginine at residue 8 and two disulfide-linked cysteines at residues of 1 and 6.	3.23	1	0	vasopressin	cardiovascular drug; hematologic agent; mitogen
s 1033 [no description available]	3.23	1	0	(trifluoromethyl)benzenes; imidazoles; pyridines; pyrimidines; secondary amino compound; secondary carboxamide	anticoronaviral agent; antineoplastic agent; tyrosine kinase inhibitor
3,6-dimethoxy-9H-carbazole [no description available]	2.41	1	0	carbazoles
mezlocillin Mezlocillin: Semisynthetic ampicillin-derived acylureido penicillin. It has been proposed for infections with certain anaerobes and may be useful in inner ear, bile, and CNS infections.. mezlocillin : A penicillin in which the substituent at position 6 of the penam ring is a (2R)-2-[3-(methanesulfonyl)-2-oxoimidazolidine-1-carboxamido]-2-phenylacetamido group.	8.57	39	12	penicillin allergen; penicillin	antibacterial drug
amygdalin (R)-amygdalin : An amygdalin in which the stereocentre on the cyanohydrin function has R-configuration.	2.04	1	0	amygdalin	antineoplastic agent; apoptosis inducer; plant metabolite
cefsulodin Cefsulodin: A pyridinium-substituted semisynthetic, broad-spectrum antibacterial used especially for Pseudomonas infections in debilitated patients.. cefsulodin : A pyridinium-substituted semi-synthetic, broad-spectrum, cephalosporin antibiotic.	2.93	4	0	cephalosporin; organosulfonic acid; primary carboxamide	antibacterial drug
polidocanol Polidocanol: An alkyl polyglycol ether of LAURYL ALCOHOL, chemically defined as an alcohol ethoxylate having an average alkyl chain of 12–14 carbon atoms, and an ethylene oxide chain of 9 ethylene oxide units. It is used as a detergent, and medically as a local anesthetic, and as a sclerosing agent for the treatment of ESOPHAGEAL AND GASTRIC VARICES and VARICOSE VEINS.. polidocanol : A hydroxypolyether that is nonaethylene glycol in which one of the terminal hydroxy functions is substituted by a lauryl (dodecyl) group.	1.96	1	0	hydroxypolyether	hepatotoxic agent; nonionic surfactant; sclerotherapy agent
mitobronitol Mitobronitol: Brominated analog of MANNITOL which is an antineoplastic agent appearing to act as an alkylating agent.	2.04	1	0	alcohol; organobromine compound
tropisetron Tropisetron: An indole derivative and 5-HT3 RECEPTOR antagonist that is used for the prevention of nausea and vomiting.. tropisetron : An indolyl carboxylate ester obtained by formal condensation of the carboxy group of indole-3-carboxylic acid with the hydroxy group of tropine.	2.04	1	0	indolyl carboxylic acid
tiamulin tiamulin: 81723 HFU and tiamutin are for fumarate salt; prevents senescence in ascomycete; pleuromutilin derivative; RN given refers to ((3aS-(3aalpha,4beta,5alpha,6alpha,8beta,9alpha,9abeta,10S*))-isomer. tiamulin : A carbotricyclic compound that is pleuromutilin in which the hydroxyacetate group is replaced by a 2-{[2-(diethylamino)ethyl]sulfanyl}acetate group. An antibacterial drug, tiamulin is used in veterinary medicine (generally as its hydrogen fumarate salt) for the treatment of swine dysentery caused by Serpulina hyodysenteriae.	2.74	3	0	carbotricyclic compound; carboxylic ester; cyclic ketone; organic sulfide; secondary alcohol; semisynthetic derivative; tertiary amino compound; tetracyclic diterpenoid	antibacterial drug
leuprolide Leuprolide: A potent synthetic long-acting agonist of GONADOTROPIN-RELEASING HORMONE that regulates the synthesis and release of pituitary gonadotropins, LUTEINIZING HORMONE and FOLLICLE STIMULATING HORMONE.. leuprolide : An oligopeptide comprising pyroglutamyl, histidyl, tryptophyl, seryl, tyrosyl, D-leucyl, leucyl, arginyl, and N-ethylprolinamide residues joined in sequence. It is a synthetic nonapeptide analogue of gonadotropin-releasing hormone, and is used as a subcutaneous hydrogel implant (particularly as the acetate salt) for the treatment of prostate cancer and for the suppression of gonadal sex hormone production in children with central precocious puberty.	2.44	2	0	oligopeptide	anti-estrogen; antineoplastic agent; gonadotropin releasing hormone agonist
octotropine methylbromide octotropine methylbromide: minor descriptor (65-86); on line & INDEX MEDICUS search TROPANES (69-86); RN given refers to endo-isomer. anisotropine methylbromide : A quaternary ammonium salt resulting from the reaction of the amino group of anisotropine with methyl bromide.	2.04	1	0
fludarabine [no description available]	2.44	2	0	purine nucleoside
propylthiouracil Propylthiouracil: A thiourea antithyroid agent. Propythiouracil inhibits the synthesis of thyroxine and inhibits the peripheral conversion of throxine to tri-iodothyronine. It is used in the treatment of hyperthyroidism. (From Martindale, The Extra Pharmacopeoia, 30th ed, p534). 6-propyl-2-thiouracil : A pyrimidinethione consisting of uracil in which the 2-oxo group is substituted by a thio group and the hydrogen at position 6 is substituted by a propyl group.	4.73	5	0	pyrimidinethione	antidote to paracetamol poisoning; antimetabolite; antioxidant; antithyroid drug; carcinogenic agent; EC 1.14.13.39 (nitric oxide synthase) inhibitor; hormone antagonist
methylatropine nitrate [no description available]	2.04	1	0
sesquiterpenes [no description available]	2.48	2	0
etomidate Etomidate: Imidazole derivative anesthetic and hypnotic with little effect on blood gases, ventilation, or the cardiovascular system. It has been proposed as an induction anesthetic.. etomidate : The ethyl ester of 1-[(1R)-1-phenylethyl]-1H-imidazole-5-carboxylic acid. It is an intravenous general anaesthetic with no analgesic activity.	3.58	2	0	ethyl ester; imidazoles	intravenous anaesthetic; sedative
mercaptopurine Mercaptopurine: An antimetabolite antineoplastic agent with immunosuppressant properties. It interferes with nucleic acid synthesis by inhibiting purine metabolism and is used, usually in combination with other drugs, in the treatment of or in remission maintenance programs for leukemia.. purine-6-thiol : A thiol that is the tautomer of mercaptopurine.. mercaptopurine : A member of the class of purines that is 6,7-dihydro-1H-purine carrying a thione group at position 6. An adenine analogue, it is used in the treatment of acute lymphocytic leukemia (ALL), chronic myeloid leukemia (CML), Crohn's disease, and ulcerative colitis.	4.24	5	0	aryl thiol; purines; thiocarbonyl compound	anticoronaviral agent; antimetabolite; antineoplastic agent
thioinosine Thioinosine: Sulfhydryl analog of INOSINE that inhibits nucleoside transport across erythrocyte plasma membranes, and has immunosuppressive properties. It has been used similarly to MERCAPTOPURINE in the treatment of leukemia. (From Martindale, The Extra Pharmacopoeia, 30th ed, p503)	2.04	1	0
pyrantel Pyrantel: A depolarizing neuromuscular-blocking agent, that causes persistent nicotinic activation resulting in spastic paralysis of susceptible nematodes. It is a drug of second-choice after benzimidazoles for treatment of ascariasis, hookworm, and pinworm infections, being effective after a single dose. (From Smith and Reynard, Textbook of Pharmacology, 1992, p920). pyrantel : A carboxamidine that is 1,4,5,6-tetrahydropyrimidine that is substituted at position 1 by a methyl group and at position 2 by an (E)-2-(2-thienyl)vinyl group. It is used, particularly as the embonate [4,4'-methylenebis(3-hydroxy-2-naphthoate)] salt, as an anthelmintic that is effective against intestinal nematodes including threadworms, roundworms and hookworms, and is included in the WHO 'Model List of Essential Medicines'.	3.23	1	0	1,4,5,6-tetrahydropyrimidines; carboxamidine; thiophenes	antinematodal drug
cotinine Cotinine: The N-glucuronide conjugate of cotinine is a major urinary metabolite of NICOTINE. It thus serves as a biomarker of exposure to tobacco SMOKING. It has CNS stimulating properties.. (-)-cotinine : An N-alkylpyrrolidine that consists of N-methylpyrrolidinone bearing a pyridin-3-yl substituent at position C-5 (the 5S-enantiomer). It is an alkaloid commonly found in Nicotiana tabacum.	2.04	1	0	N-alkylpyrrolidine; pyridines; pyrrolidin-2-ones; pyrrolidine alkaloid	antidepressant; biomarker; human xenobiotic metabolite; plant metabolite
thiothixene [no description available]	3.23	1	0	N-methylpiperazine	anticoronaviral agent
eszopiclone Eszopiclone: A pyridine, pyrazine, and piperazine derivative that is used as a HYPNOTIC AND SEDATIVE in the treatment of INSOMNIA.. eszopiclone : The (5S)- (active) enantiomer of zopiclone. Unlike almost all other hypnotic sedatives, which are approved only for the relief of short-term (6-8 weeks) insomnia, eszopiclone is approved by the U.S. Food and Drug Administration for long-term use.	3.23	1	0	zopiclone	central nervous system depressant; sedative
curcumin Curcumin: A yellow-orange dye obtained from tumeric, the powdered root of CURCUMA longa. It is used in the preparation of curcuma paper and the detection of boron. Curcumin appears to possess a spectrum of pharmacological properties, due primarily to its inhibitory effects on metabolic enzymes.. curcumin : A beta-diketone that is methane in which two of the hydrogens are substituted by feruloyl groups. A natural dyestuff found in the root of Curcuma longa.	2.54	2	0	aromatic ether; beta-diketone; diarylheptanoid; enone; polyphenol	anti-inflammatory agent; antifungal agent; antineoplastic agent; biological pigment; contraceptive drug; dye; EC 1.1.1.205 (IMP dehydrogenase) inhibitor; EC 1.1.1.21 (aldehyde reductase) inhibitor; EC 1.1.1.25 (shikimate dehydrogenase) inhibitor; EC 1.6.5.2 [NAD(P)H dehydrogenase (quinone)] inhibitor; EC 1.8.1.9 (thioredoxin reductase) inhibitor; EC 2.7.10.2 (non-specific protein-tyrosine kinase) inhibitor; EC 3.5.1.98 (histone deacetylase) inhibitor; flavouring agent; food colouring; geroprotector; hepatoprotective agent; immunomodulator; iron chelator; ligand; lipoxygenase inhibitor; metabolite; neuroprotective agent; nutraceutical; radical scavenger
benztropine Benztropine: A centrally active muscarinic antagonist that has been used in the symptomatic treatment of PARKINSON DISEASE. Benztropine also inhibits the uptake of dopamine.. benzatropine : Tropane in which a hydrogen at position 3 is substituted by a diphenylmethoxy group (endo-isomer). An acetylcholine receptor antagonist, it is used (particularly as its methanesulphonate salt) in the treatment of Parkinson's disease, and to reduce parkinsonism and akathisia side effects of antipsychotic treatments.	3.23	1	0	diarylmethane
thiouracil Thiouracil: Occurs in seeds of Brassica and Crucifera species. Thiouracil has been used as antithyroid, coronary vasodilator, and in congestive heart failure although its use has been largely supplanted by other drugs. It is known to cause blood dyscrasias and suspected of terato- and carcinogenesis.. thiouracil : A nucleobase analogue that is uracil in which the oxo group at C-2 is replaced by a thioxo group.	2.04	1	0	nucleobase analogue; thiocarbonyl compound	antithyroid drug; metabolite
thiohydantoins Thiohydantoins: Sulfur analogs of hydantoins with one or both carbonyl groups replaced by thiocarbonyl groups.	2.13	1	0
methimazole Methimazole: A thioureylene antithyroid agent that inhibits the formation of thyroid hormones by interfering with the incorporation of iodine into tyrosyl residues of thyroglobulin. This is done by interfering with the oxidation of iodide ion and iodotyrosyl groups through inhibition of the peroxidase enzyme.. methimazole : A member of the class of imidazoles that it imidazole-2-thione in which a methyl group replaces the hydrogen which is attached to a nitrogen.	3.85	3	0	1,3-dihydroimidazole-2-thiones	antithyroid drug
sulindac Sulindac: A sulfinylindene derivative prodrug whose sulfinyl moiety is converted in vivo to an active NSAID analgesic. Specifically, the prodrug is converted by liver enzymes to a sulfide which is excreted in the bile and then reabsorbed from the intestine. This helps to maintain constant blood levels with reduced gastrointestinal side effects.. sulindac : A monocarboxylic acid that is 1-benzylidene-1H-indene which is substituted at positions 2, 3, and 5 by methyl, carboxymethyl, and fluorine respectively, and in which the phenyl group of the benzylidene moiety is substituted at the para position by a methylsulfinyl group. It is a prodrug for the corresponding sulfide, a non-steroidal anti-inflammatory drug, used particularly in the treatment of acute and chronic inflammatory conditions.	3.23	1	0	monocarboxylic acid; organofluorine compound; sulfoxide	analgesic; antineoplastic agent; antipyretic; apoptosis inducer; EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor; non-narcotic analgesic; non-steroidal anti-inflammatory drug; prodrug; tocolytic agent
terbinafine [no description available]	3.54	2	0	acetylenic compound; allylamine antifungal drug; enyne; naphthalenes; tertiary amine	EC 1.14.13.132 (squalene monooxygenase) inhibitor; P450 inhibitor; sterol biosynthesis inhibitor
n-glycylalanine Gly-Ala : A dipeptide formed from glycine and L-alanine residues.	2.06	1	0	dipeptide	metabolite
drotaverin drotaverin: Hungarian drug; RN given refers to parent cpd; structure	2.45	2	0	isoquinolines
thioguanine anhydrous Thioguanine: An antineoplastic compound which also has antimetabolite action. The drug is used in the therapy of acute leukemia.. tioguanine : A 2-aminopurine that is the 6-thiono derivative of 2-amino-1,9-dihydro-6H-purine. Incorporates into DNA and inhibits synthesis. Used in the treatment of leukaemia.	3.58	2	0	2-aminopurines	anticoronaviral agent; antimetabolite; antineoplastic agent
thiourea Thiourea: A photographic fixative used also in the manufacture of resins. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), this substance may reasonably be anticipated to be a carcinogen (Merck Index, 9th ed). Many of its derivatives are ANTITHYROID AGENTS and/or FREE RADICAL SCAVENGERS.. thiourea : The simplest member of the thiourea class, consisting of urea with the oxygen atom substituted by sulfur.	2.49	2	0	one-carbon compound; thioureas; ureas	antioxidant; chromophore
D-fructopyranose [no description available]	1.94	1	0	cyclic hemiketal; D-fructose; fructopyranose	sweetening agent
succimer Succimer: A mercaptodicarboxylic acid used as an antidote to heavy metal poisoning because it forms strong chelates with them.. succimer : A sulfur-containing carboxylic acid that is succinic acid bearing two mercapto substituents at positions 2 and 3. A lead chelator used as an antedote to lead poisoning.	3.6	2	0	dicarboxylic acid; dithiol; sulfur-containing carboxylic acid	chelator
digoxin Digoxin: A cardiotonic glycoside obtained mainly from Digitalis lanata; it consists of three sugars and the aglycone DIGOXIGENIN. Digoxin has positive inotropic and negative chronotropic activity. It is used to control ventricular rate in ATRIAL FIBRILLATION and in the management of congestive heart failure with atrial fibrillation. Its use in congestive heart failure and sinus rhythm is less certain. The margin between toxic and therapeutic doses is small. (From Martindale, The Extra Pharmacopoeia, 30th ed, p666). digoxin : A cardenolide glycoside that is digitoxin beta-hydroxylated at C-12. A cardiac glycoside extracted from the foxglove plant, Digitalis lanata, it is used to control ventricular rate in atrial fibrillation and in the management of congestive heart failure with atrial fibrillation, but the margin between toxic and therapeutic doses is small.	4.21	5	0	cardenolide glycoside; steroid saponin	anti-arrhythmia drug; cardiotonic drug; EC 3.6.3.9 (Na(+)/K(+)-transporting ATPase) inhibitor; epitope
6-thioguanosine 6-thioguanosine: RN given refers to cpd without isomeric designation	2.04	1	0	purine nucleoside
streptozocin [no description available]	3.58	2	0
tamoxifen [no description available]	3.69	2	0	stilbenoid; tertiary amino compound	angiogenesis inhibitor; antineoplastic agent; bone density conservation agent; EC 1.2.3.1 (aldehyde oxidase) inhibitor; EC 2.7.11.13 (protein kinase C) inhibitor; estrogen antagonist; estrogen receptor antagonist; estrogen receptor modulator
ethionamide Ethionamide: A second-line antitubercular agent that inhibits mycolic acid synthesis.. ethionamide : A thiocarboxamide that is pyridine-4-carbothioamide substituted by an ethyl group at position 2. A prodrug that undergoes metabolic activation by conversion to the corresponding S-oxide.	3.99	4	0	pyridines; thiocarboxamide	antilipemic drug; antitubercular agent; fatty acid synthesis inhibitor; leprostatic drug; prodrug
cancidas [no description available]	3.58	2	0
fusidic acid Fusidic Acid: An antibiotic isolated from the fermentation broth of Fusidium coccineum. (From Merck Index, 11th ed). It acts by inhibiting translocation during protein synthesis.. fusidic acid : A steroid antibiotic that is isolated from the fermentation broth of Fusidium coccineum.	5.05	42	0	11alpha-hydroxy steroid; 3alpha-hydroxy steroid; alpha,beta-unsaturated monocarboxylic acid; steroid acid; steroid antibiotic; sterol ester	EC 2.7.1.33 (pantothenate kinase) inhibitor; Escherichia coli metabolite; protein synthesis inhibitor
lincomycin Lincomycin: An antibiotic produced by Streptomyces lincolnensis var. lincolnensis. It has been used in the treatment of staphylococcal, streptococcal, and Bacteroides fragilis infections.. lincomycin : A carbohydrate-containing antibiotic produced by the actinomyces Streptomyces lincolnensis.	7.09	48	0	carbohydrate-containing antibiotic; L-proline derivative; monocarboxylic acid amide; pyrrolidinecarboxamide; S-glycosyl compound	antimicrobial agent; bacterial metabolite
thiopental Thiopental: A barbiturate that is administered intravenously for the induction of general anesthesia or for the production of complete anesthesia of short duration.. thiopental : A barbiturate, the structure of which is that of 2-thiobarbituric acid substituted at C-5 by ethyl and sec-pentyl groups.	2.68	3	0	barbiturates	anticonvulsant; drug allergen; environmental contaminant; intravenous anaesthetic; sedative; xenobiotic
ranitidine Ranitidine: A non-imidazole blocker of those histamine receptors that mediate gastric secretion (H2 receptors). It is used to treat gastrointestinal ulcers.. ranitidine : A member of the class of furans used to treat peptic ulcer disease (PUD) and gastroesophageal reflux disease.	5.73	3	2	C-nitro compound; furans; organic sulfide; tertiary amino compound	anti-ulcer drug; drug allergen; environmental contaminant; H2-receptor antagonist; xenobiotic
aplaviroc aplaviroc: a spiro-diketo-piperazine; a potent noncompetitive allosteric antagonist of the CCR5 receptor with concomitantly potent antiviral effects for HIV-1; structure in first source	3.23	1	0
thiocarlide thiocarlide: major descriptor (68-85); on-line search PHENYLTHIOUREA/AA (68-85); Index Medicus search THIOCARLIDE (68-85); Antitubercular Agent	2.04	1	0	thioureas
hmr 3647 [no description available]	4.4	6	0
maraviroc [no description available]	3.23	1	0	tropane alkaloid
toremifene Toremifene: A first generation selective estrogen receptor modulator (SERM). Like TAMOXIFEN, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.	3.23	1	0	aromatic ether; organochlorine compound; tertiary amine	antineoplastic agent; bone density conservation agent; estrogen antagonist; estrogen receptor modulator
nelarabine nelarabine: prodrug of ara-G. nelarabine : A purine nucleoside in which O-methylguanine is attached to arabinofuranose via a beta-N(9)-glycosidic bond. Inhibits DNA synthesis and causes cell death; a prodrug of 9-beta-D-arabinofuranosylguanine (ara-G).	3.58	2	0	beta-D-arabinoside; monosaccharide derivative; purine nucleoside	antineoplastic agent; DNA synthesis inhibitor; prodrug
glycylproline Gly-Pro : A dipeptide consisting of L-proline having a glycyl residue attached to its alpha-amino group.	2.02	1	0	dipeptide zwitterion; dipeptide	metabolite
2-[(2-ethoxyphenoxy)-phenylmethyl]morpholine [no description available]	2.45	2	0	aromatic ether
dermatan sulfate Dermatan Sulfate: A naturally occurring glycosaminoglycan found mostly in the skin and in connective tissue. It differs from CHONDROITIN SULFATE A (see CHONDROITIN SULFATES) by containing IDURONIC ACID in place of glucuronic acid, its epimer, at carbon atom 5. (from Merck, 12th ed). alpha-L-IdopA-(1->3)-beta-D-GalpNAc4S : An oligosaccharide sulfate that is 2-acetamido-2-deoxy-4-O-sulfo-beta-D-galactopyranose in which the hydroxy group at position 3 has been converted to the corresponding alpha-L-idopyranuronoside.. dermatan sulfate : Any of a group of glycosaminoglycans with repeating units consisting of variously sulfated beta1->4-linked L-iduronyl-(alpha1->3)-N-acetyl-D-galactosamine units.	3.23	1	0	amino disaccharide; glycosylgalactose derivative; iduronic acids; oligosaccharide sulfate
raclopride Raclopride: A substituted benzamide that has antipsychotic properties. It is a dopamine D2 receptor (see RECEPTORS, DOPAMINE D2) antagonist.	2	1	0	salicylamides
dolasetron [no description available]	3.58	2	0	indolyl carboxylic acid
or 1259 [no description available]	2.04	1	0	hydrazone; nitrile; pyridazinone	anti-arrhythmia drug; cardiotonic drug; EC 3.1.4.17 (3',5'-cyclic-nucleotide phosphodiesterase) inhibitor; vasodilator agent
mannomustine Mannomustine: Nitrogen mustard derivative alkylating agent used as antineoplastic. It causes severe bone marrow depression and is a powerful vesicant.	2.04	1	0	amino alcohol
gestodene Gestodene: synthetic steroid with progestational activity; RN given refers to (17alpha)-isomer	2.44	2	0	steroid	estrogen
glucametacin glucametacin: indomethacin analog; structure	2.04	1	0
orlistat Orlistat: A lactone derivative of LEUCINE that acts as a pancreatic lipase inhibitor to limit the absorption of dietary fat; it is used in the management of obesity.. orlistat : A carboxylic ester resulting from the formal condensation of the carboxy group of N-formyl-L-leucine with the hydroxy group of (3S,4S)-3-hexyl-4-[(2S)-2-hydroxytridecyl]oxetan-2-one. A pancreatic lipase inhibitor, it is used as an anti-obesity drug.	3.23	1	0	beta-lactone; carboxylic ester; formamides; L-leucine derivative	anti-obesity agent; bacterial metabolite; EC 2.3.1.85 (fatty acid synthase) inhibitor; EC 3.1.1.3 (triacylglycerol lipase) inhibitor
quinine [no description available]	4.2	5	0	cinchona alkaloid	antimalarial; muscle relaxant; non-narcotic analgesic
zofenoprilate zofenoprilate: RN given refers to ((1(R*),2alpha,4alpha)-isomer; RN for cpd without isomeric designation not avail 9/90. zofenoprilat : A proline derivative that is 4-(phenylsulfanyl)-L-proline in which the amine proton is replaced by a (2S)-2-methyl-3-sulfanylpropanoyl group. The active metabolite of zofenopril.	2	1	0	aryl sulfide; L-proline derivative; N-acyl-L-amino acid; thiol	anticonvulsant; apoptosis inhibitor; cardioprotective agent; drug metabolite; EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor; vasodilator agent
1-(2-(2-(4-pyridyl)-2-imidazoline-1-yl)ethyl)-3-(4-carboxyphenyl)urea 1-(2-(2-(4-pyridyl)-2-imidazoline-1-yl)ethyl)-3-(4-carboxyphenyl)urea: RN given refers to parent cpd; structure in first source	2.04	1	0
isepamicin [no description available]	2.04	1	0
ifetroban ifetroban: thromboxane receptor antagonist; structure given in first source; a 7-oxabicyclo(2.2.1)heptane derivative	2.04	1	0	benzenes; monocarboxylic acid
lamifiban lamifiban: a nonpeptide glycoprotein IIb/IIIa antagonist; prevents platelet loss during experimental cardiopulmonary bypass	2.04	1	0	N-acylglycine
fospropofol [no description available]	3.23	1	0	alkylbenzene
rasagiline [no description available]	3.23	1	0	indanes; secondary amine; terminal acetylenic compound	EC 1.4.3.4 (monoamine oxidase) inhibitor; neuroprotective agent
dasatinib N-(2-chloro-6-methylphenyl)-2-((6-(4-(2-hydroxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-yl)amino)-1,3-thiazole-5-carboxamide: a dasatinib prodrug; structure in first source. dasatinib (anhydrous) : An aminopyrimidine that is 2-methylpyrimidine which is substituted at position 4 by the primary amino group of 2-amino-1,3-thiazole-5-carboxylic acid and at position 6 by a 4-(2-hydroxyethyl)piperazin-1-yl group, and in which the carboxylic acid group has been formally condensed with 2-chloro-6-methylaniline to afford the corresponding amide. A multi-targeted kinase inhibitor, it is used, particularly as the monohydrate, for the treatment of chronic, accelerated, or myeloid or lymphoid blast phase chronic myeloid leukemia. Note that the name 'dasatinib' is used to refer to the monohydrate (USAN) as well as to anhydrous dasatinib (INN).	3.23	1	0	1,3-thiazoles; aminopyrimidine; monocarboxylic acid amide; N-(2-hydroxyethyl)piperazine; N-arylpiperazine; organochlorine compound; secondary amino compound; tertiary amino compound	anticoronaviral agent; antineoplastic agent; tyrosine kinase inhibitor
telavancin telavancin: an anti-infective agent; structure in first source. telavancin : A glycopeptide that is vancomycin substituted at position N-3'' by a 2-(decylamino)ethyl group and at position C-29 by a (phosphonomethyl)aminomethyl group. Used as its hydrochloride salt for treatment of adults with complicated skin and skin structure infections caused by bacteria.	3.44	7	0	glycopeptide	antibacterial drug; antimicrobial agent
cannabidiol dimethyl ether cannabidiol dimethyl ether: metabolite of cannabidiol; structure given in first source	2.04	1	0
trimethionine [no description available]	2.44	2	0	oligopeptide
3,5-dibromo-2-(2,4-dibromophenoxy)phenol 3,5-dibromo-2-(2,4-dibromophenoxy)phenol: isolated from the marine sponge Callyspongidae; inhibits contraction of smooth muscle in ileum; structure in first source	2.13	1	0
sodium dodecyl sulfate Sodium Dodecyl Sulfate: An anionic surfactant, usually a mixture of sodium alkyl sulfates, mainly the lauryl; lowers surface tension of aqueous solutions; used as fat emulsifier, wetting agent, detergent in cosmetics, pharmaceuticals and toothpastes; also as research tool in protein biochemistry.. sodium dodecyl sulfate : An organic sodium salt that is the sodium salt of dodecyl hydrogen sulfate.	2.44	2	0	organic sodium salt	detergent; protein denaturant
mtt formazan MTT formazan: a blue MEM-insoluble mitochondrial byproduct; used to determine viability of cells with active mitochondrial dehydrogenase enzymes	2.02	1	0
alpha-chymotrypsin Chymotrypsin: A serine endopeptidase secreted by the pancreas as its zymogen, CHYMOTRYPSINOGEN and carried in the pancreatic juice to the duodenum where it is activated by TRYPSIN. It selectively cleaves aromatic amino acids on the carboxyl side.	3.2	6	0
17-ketosteroids 17-Ketosteroids: Steroids that contain a ketone group at position 17.. 17-oxo steroid : Any oxo steroid carrying the oxo group at position 17.	2.35	2	0
naphthoquinones Naphthoquinones: Naphthalene rings which contain two ketone moieties in any position. They can be substituted in any position except at the ketone groups.	2.85	3	0
sitagliptin sitagliptin : A triazolopyrazine that exhibits hypoglycemic activity.	3.85	3	0	triazolopyrazine; trifluorobenzene	EC 3.4.14.5 (dipeptidyl-peptidase IV) inhibitor; environmental contaminant; hypoglycemic agent; serine proteinase inhibitor; xenobiotic
tolcapone Tolcapone: A benzophenone and nitrophenol compound that acts as an inhibitor of CATECHOL O-METHYLTRANSFERASE, an enzyme involved in the metabolism of DOPAMINE and LEVODOPA. It is used in the treatment of PARKINSON DISEASE in patients for whom levodopa is ineffective or contraindicated.. tolcapone : Benzophenone substituted on one of the phenyl rings at C-3 and C-4 by hydroxy groups and at C-5 by a nitro group, and on the other phenyl ring by a methyl group at C-4. It is an inhibitor of catechol O-methyltransferase.	3.85	3	0	2-nitrophenols; benzophenones; catechols	antiparkinson drug; EC 2.1.1.6 (catechol O-methyltransferase) inhibitor
catechin gallate catechin gallate: structure in first source. (+)-catechin-3-O-gallate : A gallate ester obtained by formal condensation of the carboxy group of gallic acid with the (3S)-hydroxy group of (+)-catechin.	2.02	1	0	flavans; gallate ester; polyphenol	metabolite
quercetin [no description available]	2.47	2	0	7-hydroxyflavonol; pentahydroxyflavone	antibacterial agent; antineoplastic agent; antioxidant; Aurora kinase inhibitor; chelator; EC 1.10.99.2 [ribosyldihydronicotinamide dehydrogenase (quinone)] inhibitor; geroprotector; phytoestrogen; plant metabolite; protein kinase inhibitor; radical scavenger
bilirubin [no description available]	3.33	7	0	biladienes; dicarboxylic acid	antioxidant; human metabolite; mouse metabolite
calcitriol dihydroxy-vitamin D3: as a major in vitro metabolite of 1alpha,25-dihydroxyvitamin D3, produced in primary cultures of neonatal human keratinocytes	3.23	1	0	D3 vitamins; hydroxycalciol; triol	antineoplastic agent; antipsoriatic; bone density conservation agent; calcium channel agonist; calcium channel modulator; hormone; human metabolite; immunomodulator; metabolite; mouse metabolite; nutraceutical
pinosylvin pinosylvin: phytoalexin found in pine and eucalyptus	2.02	1	0	pinosylvin
hymecromone Hymecromone: A coumarin derivative possessing properties as a spasmolytic, choleretic and light-protective agent. It is also used in ANALYTICAL CHEMISTRY TECHNIQUES for the determination of NITRIC ACID.	2.41	2	0	hydroxycoumarin	antineoplastic agent; hyaluronic acid synthesis inhibitor
alprostadil [no description available]	2.04	1	0	prostaglandins E	anticoagulant; human metabolite; platelet aggregation inhibitor; vasodilator agent
vitamin d 2 Ergocalciferols: Derivatives of ERGOSTEROL formed by ULTRAVIOLET RAYS breaking of the C9-C10 bond. They differ from CHOLECALCIFEROL in having a double bond between C22 and C23 and a methyl group at C24.. vitamin D2 : A vitamin D supplement and has been isolated from alfalfa.	3.23	1	0	hydroxy seco-steroid; seco-ergostane; vitamin D	bone density conservation agent; nutraceutical; plant metabolite; rodenticide
rutin Hydroxyethylrutoside: Monohydroxyethyl derivative of rutin. Peripheral circulation stimulant used in treatment of venous disorders.	2.11	1	0	disaccharide derivative; quercetin O-glucoside; rutinoside; tetrahydroxyflavone	antioxidant; metabolite
amphotericin b Amphotericin B: Macrolide antifungal antibiotic produced by Streptomyces nodosus obtained from soil of the Orinoco river region of Venezuela.. amphotericin B : A macrolide antibiotic used to treat potentially life-threatening fungal infections.	12.09	16	1	antibiotic antifungal drug; macrolide antibiotic; polyene antibiotic	antiamoebic agent; antiprotozoal drug; bacterial metabolite
clavulanic acid Clavulanic Acid: A beta-lactam antibiotic produced by the actinobacterium Streptomyces clavuligerus. It is a suicide inhibitor of bacterial beta-lactamase enzymes. Administered alone, it has only weak antibacterial activity against most organisms, but given in combination with other beta-lactam antibiotics it prevents antibiotic inactivation by microbial lactamase.. clavulanate : The conjugate base of clavulanic acid.. clavulanic acid : Antibiotic isolated from Streptomyces clavuligerus. It acts as a suicide inhibitor of bacterial beta-lactamase enzymes.	9.31	19	0	oxapenam	antibacterial drug; anxiolytic drug; bacterial metabolite; EC 3.5.2.6 (beta-lactamase) inhibitor
pulmicort Budesonide: A glucocorticoid used in the management of ASTHMA, the treatment of various skin disorders, and allergic RHINITIS.. budesonide : A glucocorticoid steroid having a highly oxygenated pregna-1,4-diene structure. It is used mainly in the treatment of asthma and non-infectious rhinitis and for treatment and prevention of nasal polyposis.	3.85	3	0	11beta-hydroxy steroid; 20-oxo steroid; 21-hydroxy steroid; 3-oxo-Delta(1),Delta(4)-steroid; cyclic acetal; glucocorticoid; primary alpha-hydroxy ketone	anti-inflammatory drug; bronchodilator agent; drug allergen
oxymetholone Oxymetholone: A synthetic hormone with anabolic and androgenic properties. It is used mainly in the treatment of anemias. According to the Fourth Annual Report on Carcinogens (NTP 85-002), this compound may reasonably be anticipated to be a carcinogen. (From Merck Index, 11th ed). oxymetholone : A 3-oxo-5alpha- steroid that is 4,5alpha-dihydrotestosterone which is substituted by a hydroxymethylidene group at position 2 and by a methyl group at the 17alpha position. A synthetic androgen, it was mainly used for the treatment of anaemias until being replaced by treatments with fewer side effects.	3.23	1	0
eprosartan eprosartan: angiotensin II receptor antagonist. eprosartan : A member of the class of imidazoles and thiophenes that is an angiotensin II receptor antagonist used for the treatment of high blood pressure.	3.85	3	0	dicarboxylic acid; imidazoles; thiophenes	angiotensin receptor antagonist; antihypertensive agent; environmental contaminant; xenobiotic
montelukast montelukast: a leukotriene D4 receptor antagonist	3.85	3	0	aliphatic sulfide; monocarboxylic acid; quinolines	anti-arrhythmia drug; anti-asthmatic drug; leukotriene antagonist
mivacurium Mivacurium: An isoquinoline derivative that is used as a short-acting non-depolarizing agent.	3.58	2	0	isoquinolines
hemabate carboprost tromethamine : The tromethamine salt of carboprost. It is used as an abortifacient agent that is effective in both the first and second trimesters of pregnancy.	3.23	1	0
mycophenolate mofetil mycophenolate mofetil : A carboxylic ester resulting from the formal condensation between the carboxylic acid group of mycophenolic acid and the hydroxy group of 2-(morpholin-4-yl)ethanol. In the liver, it is metabolised to mycophenolic acid, an immunosuppressant for which it is a prodrug. It is widely used to prevent tissue rejection following organ transplants as well as for the treatment of certain autoimmune diseases.	3.23	1	0	carboxylic ester; ether; gamma-lactone; phenols; tertiary amino compound	anticoronaviral agent; EC 1.1.1.205 (IMP dehydrogenase) inhibitor; immunosuppressive agent; prodrug
entacapone entacapone: structure given in first source. entacapone : A monocarboxylic acid amide that is N,N-diethylprop-2-enamide in which the hydrogen at position 2 is substituted by a cyano group and the hydrogen at the 3E position is substituted by a 3,4-dihydroxy-5-nitrophenyl group.	3.85	3	0	2-nitrophenols; catechols; monocarboxylic acid amide; nitrile	antidyskinesia agent; antiparkinson drug; central nervous system drug; EC 2.1.1.6 (catechol O-methyltransferase) inhibitor
paricalcitol [no description available]	3.85	3	0	hydroxy seco-steroid; seco-cholestane	antiparathyroid drug
mangostin mangostin: xanthone from rind of Garcinia mangostana Linn. fruit. alpha-mangostin : A member of the class of xanthones that is 9H-xanthene substituted by hydroxy group at positions 1, 3 and 6, a methoxy group at position 7, an oxo group at position 9 and prenyl groups at positions 2 and 8. Isolated from the stems of Cratoxylum cochinchinense, it exhibits antioxidant, antimicrobial and antitumour activities.	7.13	1	0	aromatic ether; phenols; xanthones	antimicrobial agent; antineoplastic agent; antioxidant; plant metabolite
morin morin: a light yellowish pigment found in the wood of old fustic (Chlorophora tinctoria). morin : A pentahydroxyflavone that is 7-hydroxyflavonol bearing three additional hydroxy substituents at positions 2' 4' and 5.	2.52	2	0	7-hydroxyflavonol; pentahydroxyflavone	angiogenesis modulating agent; anti-inflammatory agent; antibacterial agent; antihypertensive agent; antineoplastic agent; antioxidant; EC 5.99.1.2 (DNA topoisomerase) inhibitor; hepatoprotective agent; metabolite; neuroprotective agent
polydatin trans-piceid : A stilbenoid that is trans-resveratrol substituted at position 3 by a beta-D-glucosyl residue.	2.02	1	0	beta-D-glucoside; monosaccharide derivative; polyphenol; stilbenoid	anti-arrhythmia drug; antioxidant; geroprotector; hepatoprotective agent; metabolite; nephroprotective agent; potassium channel modulator
cynarine cynarine: active principle of the artichoke; functions primarily as a cholagogue and choleretic and also as antilipemic agent	2.04	1	0	alkyl caffeate ester; quinic acid	plant metabolite
sdz psc 833 valspodar: nonimmunosuppressive cyclosporin analog which is a potent multidrug resistance modifier; 7-10 fold more potent than cyclosporin A; a potent P glycoprotein inhibitor; MW 1215	2.04	1	0	homodetic cyclic peptide
cerulenin Cerulenin: An epoxydodecadienamide isolated from several species, including ACREMONIUM, Acrocylindrum, and Helicoceras. It inhibits the biosynthesis of several lipids by interfering with enzyme function.. cerulenin : An epoxydodecadienamide isolated from several species, including Acremonium, Acrocylindrum and Helicoceras. It inhibits the biosynthesis of several lipids by interfering with enzyme function.	2.72	2	0	epoxide; monocarboxylic acid amide	antifungal agent; antiinfective agent; antilipemic drug; antimetabolite; antimicrobial agent; fatty acid synthesis inhibitor
7432 s Ceftibuten: A cephalosporin antibacterial agent that is used in the treatment of infections, including urinary-tract and respiratory-tract infections.. ceftibuten : A third-generation cephalosporin antibiotic with a [(2Z)-2-(2-amino-1,3-thiazol-4-yl)-4-carboxybut-2-enoyl]amino substituent at the 7 position of the cephem skeleton. An orally-administered agent, ceftibuten is used as the dihydrate to treat urinary-tract and respiratory-tract infections.	4.41	6	0	cephalosporin; dicarboxylic acid	antibacterial drug
isotretinoin Isotretinoin: A topical dermatologic agent that is used in the treatment of ACNE VULGARIS and several other skin diseases. The drug has teratogenic and other adverse effects.. isotretinoin : A retinoic acid that is all-trans-retinoic acid in which the double bond which is alpha,beta- to the carboxy group is isomerised to Z configuration. A synthetic retinoid, it is used for the treatment of severe cases of acne and other skin diseases.	3.23	1	0	retinoic acid	antineoplastic agent; keratolytic drug; teratogenic agent
epoprostenol [no description available]	3.23	1	0	prostaglandins I	mouse metabolite
indocyanine green [no description available]	3.58	2	0	1,1-diunsubstituted alkanesulfonate; benzoindole; cyanine dye
triprolidine Triprolidine: Histamine H1 antagonist used in allergic rhinitis; ASTHMA; and URTICARIA. It is a component of COUGH and COLD medicines. It may cause drowsiness.. triprolidine : An N-alkylpyrrolidine that is acrivastine in which the pyridine ring is lacking the propenoic acid substituent. It is a sedating antihistamine that is used (generally as the monohydrochloride monohydrate) for the relief of the symptoms of uticaria, rhinitis, and various pruritic skin disorders.	3.23	1	0	N-alkylpyrrolidine; olefinic compound; pyridines	H1-receptor antagonist
pitavastatin pitavastatin : A dihydroxy monocarboxylic acid that is (6E)-7-[2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl]hept-6-enoic acid in which the two hydroxy groups are located at positions 3 and 5 (the 3R,5S-stereoisomer). Used as its calcium salt for treatment of hypercholesterolemia (elevated levels of cholesterol in the blood) on patients unable to sufficiently lower their cholesterol levels by diet and exercise.	3.23	1	0	cyclopropanes; dihydroxy monocarboxylic acid; monofluorobenzenes; quinolines; statin (synthetic)	antioxidant
ethamolin monoethanolamine oleate: used for treatment of pyogenic granuloma	3.23	1	0	long-chain fatty acid
alatrofloxacin mesylate [no description available]	3.23	1	0
codeine [no description available]	4.24	5	0	morphinane alkaloid; organic heteropentacyclic compound	antitussive; drug allergen; environmental contaminant; opioid analgesic; opioid receptor agonist; prodrug; xenobiotic
cyclosporine ramihyphin A: one of the metabolites produced by Fusarium sp. S-435; RN given refers to cpd with unknown MF	4.07	4	0	homodetic cyclic peptide	anti-asthmatic drug; anticoronaviral agent; antifungal agent; antirheumatic drug; carcinogenic agent; dermatologic drug; EC 3.1.3.16 (phosphoprotein phosphatase) inhibitor; geroprotector; immunosuppressive agent; metabolite
perhexiline maleate [no description available]	3.06	1	0
phenylephrine hydrochloride Nose: A part of the upper respiratory tract. It contains the organ of SMELL. The term includes the external nose, the nasal cavity, and the PARANASAL SINUSES.. phenylephrine hydrochloride : A hydrochloride that is the monohydrochloride salt of phenylephrine.	5.32	13	1	hydrochloride
acitretin Acitretin: An oral retinoid effective in the treatment of psoriasis. It is the major metabolite of ETRETINATE with the advantage of a much shorter half-life when compared with etretinate.. acitretin : A retinoid that consists of 3,7-dimethylnona-2,4,6,8-tetraenoic acid having a 4-methoxy-2,3,6-trimethylphenyl group attached at position 9.	3.23	1	0	acitretin; alpha,beta-unsaturated monocarboxylic acid; retinoid	keratolytic drug
dihydrocodeine dihydrocodeine: RN refers to parent cpd(5alpha,6alpha)-isomer	2.04	1	0	morphinane alkaloid
estropipate estropipate: used therapeutically in menopausal patients	3.23	1	0	piperazinium salt; steroid sulfate
hydromorphone Hydromorphone: An opioid analgesic made from MORPHINE and used mainly as an analgesic. It has a shorter duration of action than morphine.. hydromorphone : A morphinane alkaloid that is a hydrogenated ketone derivative of morphine. A semi-synthetic drug, it is a centrally acting pain medication of the opioid class.	3.58	2	0	morphinane alkaloid; organic heteropentacyclic compound	mu-opioid receptor agonist; opioid analgesic
levetiracetam Levetiracetam: A pyrrolidinone and acetamide derivative that is used primarily for the treatment of SEIZURES and some movement disorders, and as a nootropic agent.. levetiracetam : A pyrrolidinone and carboxamide that is N-methylpyrrolidin-2-one in which one of the methyl hydrogens is replaced by an aminocarbonyl group, while another is replaced by an ethyl group (the S enantiomer). An anticonvulsant, it is used for the treatment of epilepsy in both human and veterinary medicine.	3.23	1	0	pyrrolidin-2-ones	anticonvulsant; environmental contaminant; xenobiotic
ly 163892 loracarbef: 1-carbacephem antibiotic; has a broad spectrum of antimicrobial activity; structure given in first source; carbacephems differ from cephalosporins in the substitution of a sulfur atom in the dihydrothiazine ring with a methylene group to form a tetrahydropyridine ring. loracarbef : A synthetic "carba" analogue of cefaclor, with carbon replacing sulfur at position 1. Used to treat a wide range of infections caused by both gram-positive and gram-negative bacteria.	3.58	2	0	carbacephem; zwitterion	antibacterial drug; antimicrobial agent
nabilone nabilone: cannabinol deriv; RN given refers to cpd without isomeric designation; structure	3.23	1	0
nalmefene nalmefene: RN given refers to 5-alpha isomer	2.45	2	0	morphinane alkaloid
naloxone Naloxone: A specific opiate antagonist that has no agonist activity. It is a competitive antagonist at mu, delta, and kappa opioid receptors.. naloxone : A synthetic morphinane alkaloid that is morphinone in which the enone double bond has been reduced to a single bond, the hydrogen at position 14 has been replaced by a hydroxy group, and the methyl group attached to the nitrogen has been replaced by an allyl group. A specific opioid antagonist, it is used (commonly as its hydrochloride salt) to reverse the effects of opioids, both following their use of opioids during surgery and in cases of known or suspected opioid overdose.	4.24	5	0	morphinane alkaloid; organic heteropentacyclic compound; tertiary alcohol	antidote to opioid poisoning; central nervous system depressant; mu-opioid receptor antagonist
oxycodone Oxycodone: A semisynthetic derivative of CODEINE.. oxycodone : A semisynthetic opioid of formula C18H21NO4 that is derived from thebaine. It is a moderately potent opioid analgesic, generally used for relief of moderate to severe pain.	3.85	3	0	organic heteropentacyclic compound; semisynthetic derivative	antitussive; mu-opioid receptor agonist; opioid analgesic
oxymorphone Oxymorphone: An opioid analgesic with actions and uses similar to those of MORPHINE, apart from an absence of cough suppressant activity. It is used in the treatment of moderate to severe pain, including pain in obstetrics. It may also be used as an adjunct to anesthesia. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1092)	3.23	1	0	morphinane alkaloid
vitamin k 1 Vitamin K 1: A family of phylloquinones that contains a ring of 2-methyl-1,4-naphthoquinone and an isoprenoid side chain. Members of this group of vitamin K 1 have only one double bond on the proximal isoprene unit. Rich sources of vitamin K 1 include green plants, algae, and photosynthetic bacteria. Vitamin K1 has antihemorrhagic and prothrombogenic activity.. phylloquinone : A member of the class of phylloquinones that consists of 1,4-naphthoquinone having methyl and phytyl groups at positions 2 and 3 respectively. The parent of the class of phylloquinones.	3.23	1	0	phylloquinones; vitamin K	cofactor; human metabolite; plant metabolite
sirolimus Sirolimus: A macrolide compound obtained from Streptomyces hygroscopicus that acts by selectively blocking the transcriptional activation of cytokines thereby inhibiting cytokine production. It is bioactive only when bound to IMMUNOPHILINS. Sirolimus is a potent immunosuppressant and possesses both antifungal and antineoplastic properties.. sirolimus : A macrolide lactam isolated from Streptomyces hygroscopicus consisting of a 29-membered ring containing 4 trans double bonds, three of which are conjugated. It is an antibiotic, immunosupressive and antineoplastic agent.	3.23	1	0	antibiotic antifungal drug; cyclic acetal; cyclic ketone; ether; macrolide lactam; organic heterotricyclic compound; secondary alcohol	antibacterial drug; anticoronaviral agent; antineoplastic agent; bacterial metabolite; geroprotector; immunosuppressive agent; mTOR inhibitor
topiramate Topiramate: A sulfamate-substituted fructose analog that was originally identified as a hypoglycemic agent. It is used for the treatment of EPILEPSY and MIGRAINE DISORDERS, and may also promote weight loss.. topiramate : A hexose derivative that is 2,3:4,5-di-O-isopropylidene-beta-D-fructopyranose in which the hydroxy group has been converted to the corresponding sulfamate ester. It blocks voltage-dependent sodium channels and is used as an antiepileptic and for the prevention of migraine.	3.23	1	0	cyclic ketal; ketohexose derivative; sulfamate ester	anticonvulsant; sodium channel blocker
trospium chloride trospium chloride : An organic chloride salt of trospium. It is an antispasmodic drug used for the treatment of overactive bladder.	3.23	1	0
alvocidib alvocidib: structure given in first source. alvocidib : A synthetic dihydroxyflavone that is 5,7-dihydroxyflavone which is substituted by a 3-hydroxy-1-methylpiperidin-4-yl group at position 8 and by a chlorine at the 2' position (the (-)-3S,4R stereoisomer). A cyclin-dependent kinase 9 (CDK9) inhibitor, it has been studied for the treatment of acute myeloid leukaemia, arthritis and atherosclerotic plaque formation.	2.04	1	0	dihydroxyflavone; hydroxypiperidine; monochlorobenzenes; tertiary amino compound	antineoplastic agent; antirheumatic drug; apoptosis inducer; EC 2.7.11.22 (cyclin-dependent kinase) inhibitor
morphine Meconium: The thick green-to-black mucilaginous material found in the intestines of a full-term fetus. It consists of secretions of the INTESTINAL GLANDS; BILE PIGMENTS; FATTY ACIDS; AMNIOTIC FLUID; and intrauterine debris. It constitutes the first stools passed by a newborn.	4.24	5	0	morphinane alkaloid; organic heteropentacyclic compound; tertiary amino compound	anaesthetic; drug allergen; environmental contaminant; geroprotector; mu-opioid receptor agonist; opioid analgesic; plant metabolite; vasodilator agent; xenobiotic
pactamycin Pactamycin: Antibiotic produced by Streptomyces pactum used as an antineoplastic agent. It is also used as a tool in biochemistry because it inhibits certain steps in protein synthesis.	2.04	1	0
anthramycin [no description available]	2.04	1	0
benzphetamine Benzphetamine: A sympathomimetic agent with properties similar to DEXTROAMPHETAMINE. It is used in the treatment of obesity. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1222). benzphetamine : Dextroamphetamine in which the the hydrogens attached to the amino group are substituted by a methyl and a benzyl group. A sympathomimetic agent with properties similar to dextroamphetamine, it is used as its hydrochloride salt in the treatment of obesity.	3.23	1	0	amphetamines; tertiary amine	adrenergic uptake inhibitor; appetite depressant; dopamine uptake inhibitor; sympathomimetic agent
cicaprost cicaprost: RN given refers to (3aS-(2E,3aalpha,4alpha(3R,4R),5beta,6aalpha))-isomer	2.04	1	0	monoterpenoid
deamino arginine vasopressin Deamino Arginine Vasopressin: A synthetic analog of the pituitary hormone, ARGININE VASOPRESSIN. Its action is mediated by the VASOPRESSIN receptor V2. It has prolonged antidiuretic activity, but little pressor effects. It also modulates levels of circulating FACTOR VIII and VON WILLEBRAND FACTOR.	3.23	1	0	heterodetic cyclic peptide	diagnostic agent; renal agent; vasopressin receptor agonist
dexmedetomidine [no description available]	3.58	2	0	medetomidine	alpha-adrenergic agonist; analgesic; non-narcotic analgesic; sedative
goserelin Goserelin: A synthetic long-acting agonist of GONADOTROPIN-RELEASING HORMONE. Goserelin is used in treatments of malignant NEOPLASMS of the prostate, uterine fibromas, and metastatic breast cancer.	3.23	1	0	organic molecular entity
iloprost Iloprost: An eicosanoid, derived from the cyclooxygenase pathway of arachidonic acid metabolism. It is a stable and synthetic analog of EPOPROSTENOL, but with a longer half-life than the parent compound. Its actions are similar to prostacyclin. Iloprost produces vasodilation and inhibits platelet aggregation.. iloprost : A carbobicyclic compound that is prostaglandin I2 in which the endocyclic oxygen is replaced by a methylene group and in which the (1E,3S)-3-hydroxyoct-1-en-1-yl side chain is replaced by a (3R)-3-hydroxy-4-methyloct-1-en-6-yn-1-yl group. A synthetic analogue of prostacyclin, it is used as the trometamol salt (generally by intravenous infusion) for the treatment of peripheral vascular disease and pulmonary hypertension.	2.04	1	0	carbobicyclic compound; monocarboxylic acid; secondary alcohol	platelet aggregation inhibitor; vasodilator agent
lacidipine [no description available]	2.04	1	0	cinnamate ester; tert-butyl ester
cytochalasin b Cytochalasin B: A cytotoxic member of the CYTOCHALASINS.. cytochalasin B : An organic heterotricyclic compound, that is a mycotoxin which is cell permeable an an inhibitor of cytoplasmic division by blocking the formation of contractile microfilaments.	2.04	1	0	cytochalasin; lactam; lactone; organic heterotricyclic compound	actin polymerisation inhibitor; metabolite; mycotoxin; platelet aggregation inhibitor
nalbuphine Nalbuphine: A narcotic used as a pain medication. It appears to be an agonist at KAPPA RECEPTORS and an antagonist or partial agonist at MU RECEPTORS.	4.06	4	0	organic heteropentacyclic compound	mu-opioid receptor antagonist; opioid analgesic
nateglinide Nateglinide: A phenylalanine and cyclohexane derivative that acts as a hypoglycemic agent by stimulating the release of insulin from the pancreas. It is used in the treatment of TYPE 2 DIABETES.. nateglinide : An N-acyl-D-phenylalanine resulting from the formal condensation of the amino group of D-phenylalanine with the carboxy group of trans-4-isopropylcyclohexanecarboxylic acid. An orally-administered, rapidly-absorbed, short-acting insulinotropic agent, it is used for the treatment of type 2 diabetes mellitus.	3.85	3	0	phenylalanine derivative
vinorelbine [no description available]	4.07	4	0	acetate ester; methyl ester; organic heteropentacyclic compound; organic heterotetracyclic compound; ring assembly; vinca alkaloid	antineoplastic agent; photosensitizing agent
zuclopenthixol zuclopenthixol : The (Z)-isomer of clopenthixol.	2	1	0	clopenthixol	alpha-adrenergic antagonist; dopaminergic antagonist; first generation antipsychotic; H1-receptor antagonist; serotonergic antagonist
silodosin silodosin: an alpha(1a)-adrenoceptor-selective antagonist; structure given in first source	3.23	1	0	indolecarboxamide
cannabigerol cannabigerol: RN given refers to (E)-isomer; structure given in first source. cannabigerol : A member of the class of resorcinols that is resorcinol which is substituted by a (2E)-3,7-dimethylocta-2,6-dien-1-yl group at position 2 and by a pentyl group at position 5. It is a natural product found in Cannabis sativa and Helichrysum species.	2.04	1	0	phytocannabinoid; resorcinols	anti-inflammatory agent; antibacterial agent; antioxidant; appetite enhancer; cannabinoid receptor agonist; neuroprotective agent; plant metabolite
irisquinone irisquinone: from seeds of Iris pallasii Iridaceae; RN given refers to (Z)-isomer	2.04	1	0
fluvoxamine Fluvoxamine: A selective serotonin reuptake inhibitor that is used in the treatment of DEPRESSION and a variety of ANXIETY DISORDERS.. fluvoxamine : An oxime O-ether that is benzene substituted by a (1E)-N-(2-aminoethoxy)-5-methoxypentanimidoyl group at position 1 and a trifluoromethyl group at position 4. It is a selective serotonin reuptake inhibitor that is used for the treatment of obsessive-compulsive disorder.	3.54	2	0	(trifluoromethyl)benzenes; 5-methoxyvalerophenone O-(2-aminoethyl)oxime	antidepressant; anxiolytic drug; serotonin uptake inhibitor
su 11248 [no description available]	3.23	1	0	monocarboxylic acid amide; pyrroles	angiogenesis inhibitor; antineoplastic agent; EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor; immunomodulator; neuroprotective agent; vascular endothelial growth factor receptor antagonist
mitoguazone Mitoguazone: Antineoplastic agent effective against myelogenous leukemia in experimental animals. Also acts as an inhibitor of animal S-adenosylmethionine decarboxylase.. mitoguazone : A hydrazone obtained by formal condensation of the two carbonyl groups of methylglyoxal with the primary amino groups of two molecules of aminoguanidine.	2.04	1	0	guanidines; hydrazone	antineoplastic agent; apoptosis inducer; EC 4.1.1.50 (adenosylmethionine decarboxylase) inhibitor
romidepsin depsipeptide : A natural or synthetic compound having a sequence of amino and hydroxy carboxylic acid residues (usually alpha-amino and alpha-hydroxy acids), commonly but not necessarily regularly alternating.	2.04	1	0	cyclodepsipeptide; heterocyclic antibiotic; organic disulfide	antineoplastic agent; EC 3.5.1.98 (histone deacetylase) inhibitor
(6E)-7-[3-(4-fluorophenyl)-1-(propan-2-yl)-1H-indol-2-yl]-3,5-dihydroxyhept-6-enoic acid (6E)-7-[3-(4-fluorophenyl)-1-(propan-2-yl)-1H-indol-2-yl]-3,5-dihydroxyhept-6-enoic acid : A dihydroxy monocarboxylic acid that is N-isopropylindole which is substituted at position 3 by a p-fluorophenyl group and at position 2 by a 6-carboxy-3,5-dihydroxyhex-1-en-1-yl group. It has four possible diastereoisomers.	3.83	3	0	dihydroxy monocarboxylic acid; indoles; organofluorine compound
15-hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic acid 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid: A stable prostaglandin endoperoxide analog which serves as a thromboxane mimetic. Its actions include mimicking the hydro-osmotic effect of VASOPRESSIN and activation of TYPE C PHOSPHOLIPASES. (From J Pharmacol Exp Ther 1983;224(1): 108-117; Biochem J 1984;222(1):103-110)	1.97	1	0
levorphanol Levorphanol: A narcotic analgesic that may be habit-forming. It is nearly as effective orally as by injection.	3.23	1	0	morphinane alkaloid
arsenic Arsenic: A shiny gray element with atomic symbol As, atomic number 33, and atomic weight 75. It occurs throughout the universe, mostly in the form of metallic arsenides. Most forms are toxic. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), arsenic and certain arsenic compounds have been listed as known carcinogens. (From Merck Index, 11th ed)	3.04	1	0	metalloid atom; pnictogen	micronutrient
naltrexone Naltrexone: Derivative of noroxymorphone that is the N-cyclopropylmethyl congener of NALOXONE. It is a narcotic antagonist that is effective orally, longer lasting and more potent than naloxone, and has been proposed for the treatment of heroin addiction. The FDA has approved naltrexone for the treatment of alcohol dependence.. naltrexone : An organic heteropentacyclic compound that is naloxone substituted in which the allyl group attached to the nitrogen is replaced by a cyclopropylmethyl group. A mu-opioid receptor antagonist, it is used to treat alcohol dependence.	3.83	3	0	cyclopropanes; morphinane-like compound; organic heteropentacyclic compound	antidote to opioid poisoning; central nervous system depressant; environmental contaminant; mu-opioid receptor antagonist; xenobiotic
morphine-6-glucuronide morphine-6-glucuronide: RN given refers to (5alpha,6alpha)-isomer	2.04	1	0	morphinane alkaloid
dextromethorphan Dextromethorphan: Methyl analog of DEXTRORPHAN that shows high affinity binding to several regions of the brain, including the medullary cough center. This compound is an NMDA receptor antagonist (RECEPTORS, N-METHYL-D-ASPARTATE) and acts as a non-competitive channel blocker. It is one of the widely used ANTITUSSIVES, and is also used to study the involvement of glutamate receptors in neurotoxicity.. dextromethorphan : A 6-methoxy-11-methyl-1,3,4,9,10,10a-hexahydro-2H-10,4a-(epiminoethano)phenanthrene in which the sterocenters at positions 4a, 10 and 10a have S-configuration. It is a prodrug of dextrorphan and used as an antitussive drug for suppressing cough.	3.23	1	0	6-methoxy-11-methyl-1,3,4,9,10,10a-hexahydro-2H-10,4a-(epiminoethano)phenanthrene	antitussive; environmental contaminant; neurotoxin; NMDA receptor antagonist; oneirogen; prodrug; xenobiotic
butorphanol Butorphanol: A synthetic morphinan analgesic with narcotic antagonist action. It is used in the management of severe pain.. butorphanol : Levorphanol in which a hydrogen at position 14 of the morphinan skeleton is substituted by hydroxy and one of the hydrogens of the N-methyl group is substituted by cyclopropyl. A semi-synthetic opioid agonist-antagonist analgesic, it is used as its (S,S)-tartaric acid salt for relief or moderate to severe pain.	3.85	3	0	morphinane alkaloid	antitussive; kappa-opioid receptor agonist; mu-opioid receptor agonist; opioid analgesic
cefodizime cefodizime: RN given refers to (6R-(6alpha,7beta(Z)))-isomer. cefodizime : A cephalosporin compound having 5-(carboxymethyl)-4-methyl-1,3-thiazol-2-yl]sulfanyl}methyl and [2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino side groups located at positions 3 and 7 respectively.	2.95	4	0	1,3-thiazoles; cephalosporin; oxime O-ether	antibacterial drug; EC 1.14.18.1 (tyrosinase) inhibitor
methylnaltrexone methylnaltrexone: RN given refers to parent cpd(5alpha)-isomer	2.04	1	0	phenanthrenes
cefixime [no description available]	4.53	7	0	cephalosporin	antibacterial drug; drug allergen
lisinopril Lisinopril: One of the ANGIOTENSIN-CONVERTING ENZYME INHIBITORS (ACE inhibitors), orally active, that has been used in the treatment of hypertension and congestive heart failure.	3.85	3	0	dipeptide	EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor
benazepril benazepril: structure given in first source. benazepril : A benzazepine that is benazeprilat in which the carboxy group of the 2-amino-4-phenylbutanoic acid moiety has been converted to the corresponding ethyl ester. It is used (generally as its hydrochloride salt) as a prodrug for the angiotensin-converting enzyme inhibitor benazeprilat in the treatment of hypertension and heart failure.	3.23	1	0	benzazepine; dicarboxylic acid monoester; ethyl ester; lactam	EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor; prodrug
ramipril Ramipril: A long-acting angiotensin-converting enzyme inhibitor. It is a prodrug that is transformed in the liver to its active metabolite ramiprilat.. ramipril : A dipeptide that is the prodrug for ramiprilat, the active metabolite obtained by hydrolysis of the ethyl ester group. An angiotensin-converting enzyme (ACE) inhibitor, used to treat high blood pressure and congestive heart failure.. quark : Quarks comprise one of two classes of the fundamental particles. Quarks possess fractional electric charges and are not observed in free state. The word "quark" first appears in James Joyce's Finnegans Wake and has been chosen by Murray Gell-Mann as a name for fundamental building blocks of particles.	3.58	2	0	azabicycloalkane; cyclopentapyrrole; dicarboxylic acid monoester; dipeptide; ethyl ester	bradykinin receptor B2 agonist; cardioprotective agent; EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor; matrix metalloproteinase inhibitor; prodrug
verteporfin (2R,2(1)S)-8-ethenyl-2(1),2(2)-bis(methoxycarbonyl)-17-(3-methoxy-3-oxopropyl)-2,7,12,18-tetramethyl-2,2(1)-dihydrobenzo[b]porphyrin-13-propanoic acid : The 2(1),2(2),17-trimethyl ester of (2R,2(1)S)-2(1),2(2)-dicarboxy-8-ethenyl-2,7,12,18-tetramethyl-2,2(1)-dihydrobenzo[b]porphyrin-13,17-dipropanoic acid.	3.23	1	0
indinavir sulfate Indinavir: A potent and specific HIV protease inhibitor that appears to have good oral bioavailability.	3.85	3	0	dicarboxylic acid diamide; N-(2-hydroxyethyl)piperazine; piperazinecarboxamide	HIV protease inhibitor
zimeldine Zimeldine: One of the SEROTONIN UPTAKE INHIBITORS formerly used for depression but was withdrawn worldwide in September 1983 because of the risk of GUILLAIN-BARRE SYNDROME associated with its use. (From Martindale, The Extra Pharmacopoeia, 29th ed, p385)	3.23	1	0	styrenes
2',4'-dihydroxychalcone 2',4'-dihydroxychalcone: RN given refers to (E)-isomer; RN for cpd without isomeric designation not available 6/89; structure given in first source	7.05	1	0
enalapril Enalapril: An angiotensin-converting enzyme inhibitor that is used to treat HYPERTENSION and HEART FAILURE.. enalapril : A dicarboxylic acid monoester that is ethyl 4-phenylbutanoate in which a hydrogen alpha to the carboxy group is substituted by the amino group of L-alanyl-L-proline (S-configuration).	3.58	2	0	dicarboxylic acid monoester; dipeptide	antihypertensive agent; EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor; geroprotector; prodrug
nitrofurazone Nitrofurazone: A topical anti-infective agent effective against gram-negative and gram-positive bacteria. It is used for superficial WOUNDS AND INJURIES and skin infections. Nitrofurazone has also been administered orally in the treatment of TRYPANOSOMIASIS.. nitrofurazone : A semicarbazone resulting from the formal condensation of semicarbazide with 5-nitrofuraldehyde. A broad spectrum antibacterial drug, although with little activity against Pseudomonas species, it is used as a local application for burns, ulcers, wounds and skin infections.	2.68	3	0
trientine hydrochloride [no description available]	3.23	1	0
n-methylscopolamine bromide scopolamine methobromide : A quaternary ammonium salt resulting from the reaction of the amino group of scopolamine with methyl bromide.	3.23	1	0
streptogramin a Streptogramin A: A specific streptogramin group A antibiotic produced by Streptomyces graminofaciens and other bacteria.	2.46	2	0	1,3-oxazoles; cyclic ketone; enamide; lactam; macrolide antibiotic; macrolide; pyrroline; secondary alcohol; secondary carboxamide; tertiary carboxamide	antibacterial drug; Mycoplasma genitalium metabolite
bleomycin [no description available]	3.23	1	0	bleomycin	antineoplastic agent; metabolite
heroin Heroin: A narcotic analgesic that may be habit-forming. It is a controlled substance (opium derivative) listed in the U.S. Code of Federal Regulations, Title 21 Parts 329.1, 1308.11 (1987). Sale is forbidden in the United States by Federal statute. (Merck Index, 11th ed). heroin : A morphinane alkaloid that is morphine bearing two acetyl substituents on the O-3 and O-6 positions. As with other opioids, heroin is used as both an analgesic and a recreational drug. Frequent and regular administration is associated with tolerance and physical dependence, which may develop into addiction. Its use includes treatment for acute pain, such as in severe physical trauma, myocardial infarction, post-surgical pain, and chronic pain, including end-stage cancer and other terminal illnesses.	2.35	2	0	morphinane alkaloid	mu-opioid receptor agonist; opioid analgesic; prodrug
enalaprilat anhydrous Enalaprilat: The active metabolite of ENALAPRIL and one of the potent, intravenously administered, ANGIOTENSIN-CONVERTING ENZYME INHIBITORS. It is an effective agent for the treatment of essential hypertension and has beneficial hemodynamic effects in heart failure. The drug produces renal vasodilation with an increase in sodium excretion.. enalaprilat dihydrate : The dihydrate form of enalaprilat, an angiotensin-converting enzyme (ACE) inhibitor that is used (often in the form of its prodrug, enalapril) in the treatment of hypertension and heart failure, for reduction of proteinuria and renal disease in patients with nephropathies, and for the prevention of stroke, myocardial infarction, and cardiac death in high-risk patients. Unlike enalapril, enalaprilat is not absorbed by mouth but is administered by intravenous injection.. enalaprilat (anhydrous) : Enalapril in which the ethyl ester group has been hydrolysed to the corresponding carboxylic acid. Enalaprilat is an angiotensin-converting enzyme (ACE) inhibitor and is used (often in the form of its prodrug, enalapril) in the treatment of hypertension and heart failure, for reduction of proteinuria and renal disease in patients with nephropathies, and for the prevention of stroke, myocardial infarction, and cardiac death in high-risk patients. Unlike enalapril, enalaprilat is not absorbed by mouth but is given by intravenous injection, usually as the dihydrate.	3.85	3	0	dicarboxylic acid; dipeptide	antihypertensive agent; EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor
imidapril imidapril: structure given in first source. imidapril : A member of the class of imidazolidines that is (4S)-1-methyl-2-oxoimidazolidine-4-carboxylic acid in which the hydrogen of the imidazolidine nitrogen has been substituted by (1S)-1-{[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino}ethyl group. It is the prodrug for imidaprilat, an ACE inhibitor used for the treatment of chronic heart failure.	3.4	1	1	dicarboxylic acid monoester; dipeptide; ethyl ester; imidazolidines; N-acylurea; secondary amino compound	antihypertensive agent; EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor; prodrug
mbx 1090 [no description available]	2.05	1	0
alanyl-alanyl-alanine alanyl-alanyl-alanine: RN given refers to all (L)-isomer. Ala-Ala-Ala : A tripeptide composed of three L-alanine units joined by peptide linkages.	2.44	2	0	tripeptide	metabolite
ximelagatran ximelagatran: prodrug (via hydroxylation) of melagatran & a direct thrombin inhibitor; liver toxicity concerns so AZD0837 being developed to replace this. ximelagatran : A member of the class of azetidines that is melagatran in which the carboxylic acid group has been converted to the corresponding ethyl ester and in which the amidine group has been converted into the corresponding amidoxime. A prodrug for melagatran, ximelagatran was the first orally available direct thrombin inhibitor to be brought to market as an anticoagulant, but was withdrawn in 2006 following reports of it causing liver damage.	3.23	1	0	amidoxime; azetidines; carboxamide; ethyl ester; hydroxylamines; secondary amino compound; secondary carboxamide; tertiary carboxamide	anticoagulant; EC 3.4.21.5 (thrombin) inhibitor; prodrug; serine protease inhibitor
cefuroxime [no description available]	5.4	18	0	3-(carbamoyloxymethyl)cephalosporin; furans; oxime O-ether	drug allergen
ceftriaxone [no description available]	6.84	19	1	1,2,4-triazines; 1,3-thiazoles; cephalosporin; oxime O-ether	antibacterial drug; drug allergen; EC 3.5.2.6 (beta-lactamase) inhibitor
cefepime Cefepime: A fourth-generation cephalosporin antibacterial agent that is used in the treatment of infections, including those of the abdomen, urinary tract, respiratory tract, and skin. It is effective against PSEUDOMONAS AERUGINOSA and may also be used in the empiric treatment of FEBRILE NEUTROPENIA.. cefepime : A cephalosporin bearing (1-methylpyrrolidinium-1-yl)methyl and (2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetamido groups at positions 3 and 7, respectively, of the cephem skeleton.	12.72	28	1	cephalosporin; oxime O-ether	antibacterial drug
hr 810 cefpirome: structure in first source. cefpirome : A fourth-generation cephalosporin antibiotic having 6,7-dihydro-5H-cyclopenta[b]pyridinium-1-ylmethyl and [(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino side groups located at positions 3 and 7 respectively.	3.13	5	0	cephalosporin; cyclopentapyridine
pafuramidine pafuramidine: a prodrug of furamidine	3.23	1	0
ceftazidime [no description available]	7.1	25	1	cephalosporin; oxime O-ether	antibacterial drug; drug allergen; EC 2.4.1.129 (peptidoglycan glycosyltransferase) inhibitor
alanylalanine L-alanyl-L-alanine : A dipeptide consisting of two L-alanine units joined by a peptide linkage.	2.44	2	0	dipeptide zwitterion; dipeptide	Mycoplasma genitalium metabolite
trandolapril trandolapril : A heterobicylic compound that is (2S,3aR,7aS)-1-[(2S)-2-aminopropanoyl]octahydro-1H-indole-2-carboxylic acid in which the hydrogen of the amino group is substituted by a (2R)-1-ethoxy-1-oxo-4-phenylbutan-2-yl group. It is a angiotensin-converting enzyme inhibitor and a prodrug used for the treatment of hypertension.	3.23	1	0	dicarboxylic acid monoester; dipeptide; ethyl ester; organic heterobicyclic compound; secondary amino compound; tertiary carboxamide	antihypertensive agent; EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor; prodrug
3,3'-dipentyl-2,2'-oxacarbocyanine 3,3'-dipentyl-2,2'-oxacarbocyanine: RN given refers to parent cpd. 3,3'-dipentyloxacarbocyanine : The cationic form of a C3 cyanine dye having 3-pentyl-1,3-benzoxazol-2(3H)-yl units at each end. A fluorescent compound that preferentially stains chronic myelogenic leukemia cells.	1.98	1	0	benzoxazolium ion; cyanine dye	fluorochrome
tyrosyl-alanyl-glycine tyrosyl-alanyl-glycine: RN given refers to unlabeled (L-Tyr-D-Ala)-isomer	2.02	1	0
pregabalin Pregabalin: A gamma-aminobutyric acid (GABA) derivative that functions as a CALCIUM CHANNEL BLOCKER and is used as an ANTICONVULSANT as well as an ANTI-ANXIETY AGENT. It is also used as an ANALGESIC in the treatment of NEUROPATHIC PAIN and FIBROMYALGIA.. pregabalin : A gamma-amino acid that is gamma-aminobutyric acid (GABA) carrying an isobutyl substitutent at the beta-position (the S-enantiomer). Binds with high affinity to the alpha2-delta site (an auxiliary subunit of voltage-gated calcium channels) in central nervous system tissues.	3.23	1	0	gamma-amino acid	anticonvulsant; calcium channel blocker
cefetamet cefetamet: active against Neisseria gonorrhoeae; structure given in first source. cefetamet : A cephalosporin compound having methyl and [(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino side-groups; a cephalosporin antibiotic active against Neisseria gonorrhoeae.	2.45	2	0	cephalosporin
phenylalanylalanine phenylalanylalanine: RN given refers to (L)-isomer. Phe-Ala : A dipeptide formed from L-phenylalanine and L-alanine residues.	2.44	2	0	dipeptide zwitterion; dipeptide	metabolite
alvimopan anhydrous alvimopan: mu opioid receptor antagonist; intended to treat constipation in patients taking opiates for pain	3.23	1	0	peptide
alpha-aspartylalanine alpha-aspartylalanine: found in pig brain. Asp-Ala : A dipeptide formed from L-alpha-aspartyl and L-valine residues.	2.02	1	0	dipeptide	metabolite
aliskiren aliskiren: orally active nonpeptidic renin inhibitor. aliskiren : A monomethoxybenzene compound having a 3-methoxypropoxy group at the 2-position and a multi-substituted branched alkyl substituent at the 4-position.	3.23	1	0	monocarboxylic acid amide; monomethoxybenzene	antihypertensive agent
alanyltyrosine Tyr-Ala : A dipeptide formed from L-tyrosine and L-alanine residues.	2.44	2	0	dipeptide	metabolite
triolein Triolein: (Z)-9-Octadecenoic acid 1,2,3-propanetriyl ester.. triolein : A triglyceride formed by esterification of the three hydroxy groups of glycerol with oleic acid. Triolein is one of the two components of Lorenzo's oil.	1.94	1	0	triglyceride	Caenorhabditis elegans metabolite; plant metabolite
famotidine [no description available]	4.06	4	0	1,3-thiazoles; guanidines; sulfonamide	anti-ulcer drug; H2-receptor antagonist; P450 inhibitor
carbocyanines Carbocyanines: Compounds that contain three methine groups. They are frequently used as cationic dyes used for differential staining of biological materials.	1.98	1	0	cyanine dye; organic iodide salt	fluorochrome
cefotaxime Cefotaxime: Semisynthetic broad-spectrum cephalosporin.. cefotaxime : A cephalosporin compound having acetoxymethyl and [2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino side groups.	6.41	53	0	1,3-thiazoles; cephalosporin; oxime O-ether	antibacterial drug; drug allergen
aztreonam [no description available]	5.74	15	0	beta-lactam antibiotic allergen; monobactam	antibacterial drug; drug allergen; EC 2.4.1.129 (peptidoglycan glycosyltransferase) inhibitor
ammonium sulfate Ammonium Sulfate: Sulfuric acid diammonium salt. It is used in CHEMICAL FRACTIONATION of proteins.. ammonium sulfate : An inorganic sulfate salt obtained by reaction of sulfuric acid with two equivalents of ammonia. A high-melting (decomposes above 280degreeC) white solid which is very soluble in water (70.6 g/100 g water at 0degreeC; 103.8 g/100 g water at 100degreeC), it is widely used as a fertilizer for alkaline soils.	2.07	1	0	ammonium salt; inorganic sulfate salt	fertilizer
cci 15641 [no description available]	2.05	1	0	cephalosporin
rifamycin sv rifamycin SV: RN given refers to parent cpd; structure in Merck Index, 9th ed, #8009. rifamycin SV : A member of the class of rifamycins that exhibits antibiotic and antitubercular properties.	2.63	3	0	acetate ester; cyclic ketal; lactam; macrocycle; organic heterotetracyclic compound; polyphenol; rifamycins	antimicrobial agent; antitubercular agent; bacterial metabolite
ginkgolide b [no description available]	2.04	1	0
tellurium Tellurium: An element that is a member of the chalcogen family. It has the atomic symbol Te, atomic number 52, and atomic weight 127.60. It has been used as a coloring agent and in the manufacture of electrical equipment. Exposure may cause nausea, vomiting, and CNS depression.	2.37	2	0	chalcogen; metalloid atom
ceftiofur [no description available]	2.46	2	0
cefpodoxime [no description available]	3.85	3	0	carboxylic acid; cephalosporin	antibacterial drug
palonosetron Palonosetron: Isoquinoline and quinuclidine derivative that acts as a 5-HT3 RECEPTOR antagonist. It is used in the prevention of nausea and vomiting induced by cytotoxic chemotherapy, and for the prevention of post-operative nausea and vomiting.. palonosetron : An organic heterotricyclic compound that is an antiemetic used (as its hydrochloride salt) in combination with netupitant (under the trade name Akynzeo) to treat nausea and vomiting in patients undergoing cancer chemotherapy.	3.58	2	0	azabicycloalkane; delta-lactam; organic heterotricyclic compound	antiemetic; serotonergic antagonist
cefatrizine Cefatrizine: Orally active semisynthetic cephalosporin antibiotic with broad-spectrum activity.. cefatrizine : A cephalosporin compound having (1H-1,2,3-triazol-4-ylsulfanyl)methyl and [(2R)-2-amino-2-(4-hydroxyphenyl)]acetamido side-groups. An antibacterial drug first prepared in the 1970s, it has more recently been found to be an inhibitor of eukaryotic elongation factor-2 kinase (eEF2K), which is known to regulate apoptosis, autophagy and ER stress in many types of human cancers.	2.45	2	0	amino acid amide; carboxylic acid; cephalosporin; phenols; semisynthetic derivative; triazoles	antibacterial drug; EC 2.7.11.20 (elongation factor 2 kinase) inhibitor
aspartyllysine aspartyllysine: from feces of axenic mice. Asp-Lys : A dipeptide formed from L-alpha-aspartyl and L-lysine residues.	2.02	1	0	dipeptide	metabolite
eniporide eniporide: inhibits NHE-1 isoform; structure in first source	2.04	1	0
cilastatin [no description available]	2.73	3	0	carboxamide; L-cysteine derivative; non-proteinogenic L-alpha-amino acid; organic sulfide	EC 3.4.13.19 (membrane dipeptidase) inhibitor; environmental contaminant; protease inhibitor; xenobiotic
nitrocefin nitrocefin: chromogenic cephalosporin used for detection of beta-lactamase activity; Cefinase is name for nitrocefin on paper disc; RN given refers to (6R-(3(E),6 alpha,7 beta))-isomer; structure for mono-Na salt in second source	2.49	2	0
rifaximin [no description available]	3.23	1	0	acetate ester; cyclic ketal; lactam; macrocycle; organic heterohexacyclic compound; rifamycins; semisynthetic derivative	antimicrobial agent; gastrointestinal drug; orphan drug
sibiromycin [no description available]	2.04	1	0	aminoglycoside antibiotic; hemiaminal; phenols; pyrrolobenzodiazepine	antineoplastic agent; bacterial metabolite
everolimus [no description available]	3.23	1	0	cyclic acetal; cyclic ketone; ether; macrolide lactam; primary alcohol; secondary alcohol	anticoronaviral agent; antineoplastic agent; geroprotector; immunosuppressive agent; mTOR inhibitor
ixabepilone [no description available]	3.58	2	0	1,3-thiazoles; beta-hydroxy ketone; epoxide; lactam; macrocycle	antineoplastic agent; microtubule-destabilising agent
cannabigerolic acid cannabigerolic acid: structure in first source. cannabigerolic acid : A dihydroxybenzoic acid that is olivetolic acid in which the hydrogen at position 3 is substituted by a geranyl group. A biosynthetic precursor to Delta(9)-tetrahydrocannabinol, the principal psychoactive constituent of the cannabis plant.	2.04	1	0	dihydroxybenzoic acid; diterpenoid; phytocannabinoid; polyketide; resorcinols
azlocillin Azlocillin: A semisynthetic ampicillin-derived acylureido penicillin.. azlocillin : A semisynthetic penicillin having a 6beta-{(2R)-2-[(2-oxoimidazolidine-1-carbonyl)amino]-2-phenylacetyl}amino side-group. It is an antibiotic used in treating infections caused by Pseudomonas aeruginosa, Escherichia coli and Haemophilus influenzae.	10.11	10	1	penicillin allergen; penicillin; semisynthetic derivative	antibacterial drug
panduratin a panduratin A: isolated from Kaempferia pandurata; structure in first source	2.05	1	0	diarylheptanoid	metabolite
verlukast verlukast: LTD4 receptor antagonist	2.04	1	0
ceftizoxime [no description available]	4.65	8	0	cephalosporin	antibacterial drug
1-methyl-d-lysergic acid butanolamide [no description available]	3.58	2	0	ergot alkaloid; monocarboxylic acid amide	serotonergic antagonist; sympatholytic agent; vasoconstrictor agent
carumonam carumonam: structure given in first source; RN given refers to (2S-(2alpha,3alpha(Z))-isomer. carumonam : An N-sulfonated monobactam antibiotic.	2.45	2	0	monobactam	antibacterial drug
beta-escin [no description available]	2.15	1	0
nitrofurantoin Nitrofurantoin: A urinary anti-infective agent effective against most gram-positive and gram-negative organisms. Although sulfonamides and antibiotics are usually the agents of choice for urinary tract infections, nitrofurantoin is widely used for prophylaxis and long-term suppression.. nitrofurantoin : An imidazolidine-2,4-dione that is hydantoin substituted at position 1 by a [(5-nitro-2-furyl)methylene]amino group. An antibiotic that damages bacterial DNA.	5.73	16	0	imidazolidine-2,4-dione; nitrofuran antibiotic; organonitrogen heterocyclic antibiotic; organooxygen heterocyclic antibiotic	antibacterial drug; antiinfective agent; hepatotoxic agent
methampicillin methampicillin: RN given refers to parent cpd(2S-(2alpha,5alpha,6beta(S*)))-isomer. metampicillin : A penicillin compound having a 6beta-(2R)-2-(methylideneamino)-2-phenylacetamido side-group.	2.73	3	0	penicillin allergen; penicillin
nifurtimox Nifurtimox: A nitrofuran thiazine that has been used against TRYPANOSOMIASIS.	2	1	0	nitrofuran antibiotic
butylscopolammonium bromide Butylscopolammonium Bromide: Antimuscarinic quaternary ammonium derivative of scopolamine used to treat cramps in gastrointestinal, urinary, uterine, and biliary tracts, and to facilitate radiologic visualization of the gastrointestinal tract.	2.04	1	0
furagin Furagin: Nitrofuran derivative anti-infective agent used for urinary tract infections.. furagin : An imidazolidine-2,4-dione that is hydantoin substituted at position 1 by a [3-(5-nitro-2-furyl)prop-2-en-1-ylidene]amino group (the configuration of the C=C and C=N bonds in the grouping that links the two heterocycles is not specified). A nitrofuran antibiotic with properties similar to nitrofurantoin, furagin is used in the treatment of urinary tract infections.	3.35	1	1
eritoran eritoran : A lipid A derivative used for the treatment of severe sepsis.	2.04	1	0	lipid As
dantrolene [no description available]	3.58	2	0
roxithromycin (E)-roxithromycin : A major geometrical isomer of roxithromycin.	2.15	1	0	roxithromycin	environmental contaminant; xenobiotic
cefdinir [no description available]	3.23	1	0	cephalosporin; ketoxime	antibacterial drug
fumagillin [no description available]	2.04	1	0	antibiotic antifungal drug; carboxylic ester; dicarboxylic acid monoester; meroterpenoid; organooxygen heterocyclic antibiotic; spiro-epoxide	angiogenesis inhibitor; antibacterial drug; antimicrobial agent; antiprotozoal drug; fungal metabolite; methionine aminopeptidase 2 inhibitor
etonogestrel [no description available]	3.23	1	0	17beta-hydroxy steroid; 3-oxo-Delta(4) steroid; terminal acetylenic compound	contraceptive drug; female contraceptive drug; progestin
artesunate artesunic acid: RN given for (3R-(3alpha,5abeta,6beta,8abeta,9alpha,10alpha,12beta,(2aR*))-isomer; succinic ester of artemether	2.04	1	0	artemisinin derivative; cyclic acetal; dicarboxylic acid monoester; hemisuccinate; semisynthetic derivative; sesquiterpenoid	antimalarial; antineoplastic agent; ferroptosis inducer
dexniguldipine niguldipine: structure given in first source; clinical modulator of multidrug resistance	2.04	1	0	diarylmethane
napsagatran napsagatran: structure given in first source	2.04	1	0
temsirolimus [no description available]	3.58	2	0	macrolide lactam
dutasteride Dutasteride: A 5-ALPHA-REDUCTASE INHIBITOR that is reported to inhibit both type-1 and type2 isoforms of the enzyme and is used to treat BENIGN PROSTATIC HYPERPLASIA.. dutasteride : An aza-steroid that is inasteride in which the tert-butyl group is replaced by a 2,5-bis(trifluoromethyl)phenyl group. A synthetic 4-azasteroid, dutasteride is a selective inhibitor of both the type 1 and type 2 isoforms of steroid 5alpha-reductase, an intracellular enzyme that converts testosterone to 5alpha-dihydrotestosterone. Dutasteride is used for the treatment of symptomatic benign prostatic hyperplasia in men with an enlarged prostate gland.	3.23	1	0	(trifluoromethyl)benzenes; aza-steroid; delta-lactam	antihyperplasia drug; EC 1.3.1.22 [3-oxo-5alpha-steroid 4-dehydrogenase (NADP(+))] inhibitor
retapamulin retapamulin: a synthetic pleuromutilin	2.04	1	0	carbotricyclic compound; carboxylic ester; cyclic ketone
lu 208075 ambrisentan: an ET(A) receptor antagonist and antihypertensive agent; studied for use in pulmonary arterial hypertension	3.23	1	0	diarylmethane
bms188797 [no description available]	2.04	1	0
bibx 1382bs BIBX 1382BS: an ErbB receptor kinase inhibitor; no further information available 4/2001	3.23	1	0	substituted aniline
fesoterodine fesoterodine: a muscarinic antagonist for treatment of overactive bladder	3.23	1	0	diarylmethane
phenylalanylglycine phenylalanylglycine: RN given refers to (DL)-isomer. Phe-Gly : A dipeptide formed from L-phenylalanine and glycine residues.	2.06	1	0	dipeptide	metabolite
glutamylalanine Glu-Ala : A dipeptide formed from L-alpha-glutamyl and L-alanine residues.	2.44	2	0	dipeptide	metabolite
phenylalanylphenylalanine Phe-Phe : A dipeptide formed from two L-phenylalanine residues.	2.44	2	0	dipeptide; L-aminoacyl-L-amino acid zwitterion	human blood serum metabolite; Mycoplasma genitalium metabolite
phenylalanyl-valine Val-Phe : A dipeptide formed from L-valine and L-phenylalanine residues.	2.44	2	0	dipeptide	metabolite
alanylglycine [no description available]	2.44	2	0	dipeptide zwitterion; dipeptide	metabolite
valyltyrosine valyltyrosine: from sardine muscle hydrolyzate. Val-Tyr : A dipeptide formed from L-valine and L-tyrosine residues.	2.44	2	0	dipeptide	metabolite
lysylglutamic acid lysylglutamic acid: a geroprotective agent. Lys-Glu : A dipeptide formed from L-lysine and L-glutamic acid residues.	2.02	1	0	dipeptide	metabolite
Ala-Lys Ala-Lys : A dipeptide obtained by formal condensation of the carboxy group of L-alanine with the alpha-amino group of L-lysine.	2.44	2	0	dipeptide	marine metabolite
glycylhistidine glycylhistidine: RN given refers to (L)-isomer. Gly-His : A dipeptide composed of glycine and L-histidine joined by a peptide linkage.	2.44	2	0	dipeptide zwitterion; dipeptide	metabolite
13-epi-sclareol 13-epi-sclareol: an unusual labdane diterpene from the roots of Coleus forskohlii with cell growth inhibitory action in breast and uterine cancers in vitro; structure in first source	2.25	1	0
isoleucyl-tyrosine isoleucyl-tyrosine: a dipeptide with antihypertensive effect. Ile-Tyr : A dipeptide formed from L-isoleucine and L-tyrosine residues.	2.44	2	0	dipeptide	metabolite
formazans Formazans: Colored azo compounds formed by the reduction of tetrazolium salts. Employing this reaction, oxidoreductase activity can be determined quantitatively in tissue sections by allowing the enzymes to act on their specific substrates in the presence of tetrazolium salts.	2.02	1	0
thioacetazone Thioacetazone: A thiosemicarbazone that is used in association with other antimycobacterial agents in the initial and continuation phases of antituberculosis regimens. Thiacetazone containing regimens are less effective than the short-course regimen recommended by the International Union Against Tuberculosis and are used in some developing countries to reduce drug costs. (From Martindale, The Extra Pharmacopoeia, 30th ed, p217). thiosemicarbazone : A hydrazone resulting from the formal condensation of an aldehyde or ketone with the non-thioacylated nitrogen of thiosemicarbazide or its substituted derivatives.	2.04	1	0
azimilide azimilide: structure given in first source; RN given refers to dihydrochloride	2.04	1	0	imidazolidine-2,4-dione
gemifloxacin Gemifloxacin: A naphthyridine and fluoroquinolone derivative antibacterial agent and DNA TOPOISOMERASE II inhibitor that is used for the treatment of community-acquired pneumonia and acute bacterial infections associated with chronic bronchitis.. gemifloxacin : A 1,4-dihydro-1,8-naphthyridine with a carboxy group at the 3-position, an oxo sustituent at the 4-position, a fluoro substituent at the 5-position and a substituted pyrrolin-1-yl group at the 7-position.	4.08	4	0	1,8-naphthyridine derivative; fluoroquinolone antibiotic; monocarboxylic acid; quinolone antibiotic	antibacterial drug; antimicrobial agent; topoisomerase IV inhibitor
dexlansoprazole Dexlansoprazole: The R-isomer of lansoprazole that is used to treat severe GASTROESOPHAGEAL REFLUX DISEASE.	3.23	1	0	benzimidazoles; sulfoxide
fosinopril [no description available]	3.23	1	0
armodafinil armodafinil : A 2-[(diphenylmethyl)sulfinyl]acetamide that has R configuration at the sulfur atom. Like its racemate, modafinil, it is used for the treatment of sleeping disorders such as narcolepsy, obstructive sleep apnoea, and shift-work sleep disorder. Peak concentration in the blood later occurs later following administration than with modafinil, so it is thought that armodafinil may be more effective than modafinil in treating people with excessive daytime sleepiness.	3.23	1	0	2-[(diphenylmethyl)sulfinyl]acetamide	central nervous system stimulant; eugeroic
amoxicillin-potassium clavulanate combination Amoxicillin-Potassium Clavulanate Combination: A fixed-ratio combination of amoxicillin trihydrate and potassium clavulanate.	7.57	16	1
tomopenem [no description available]	2.73	3	0
valyl-prolyl-proline Val-Pro-Pro : A tripeptide composed of L-valine and two L-proline units joined by peptide linkages.	2.44	2	0	tripeptide	metabolite
sincalide Sincalide: An octapeptide hormone present in the intestine and brain. When secreted from the gastric mucosa, it stimulates the release of bile from the gallbladder and digestive enzymes from the pancreas.	3.23	1	0	oligopeptide
avibactam avibactam : A member of the class of azabicycloalkanes that is (2S,5R)-7-oxo-1,6-diazabicyclo[3.2.1]octane-2-carboxamide in which the amino hydrogen at position 6 is replaced by a sulfooxy group. Used (in the form of its sodium salt) in combination with ceftazidime pentahydrate for the treatment of complicated urinary tract infections including pyelonephritis.	2.25	1	0	azabicycloalkane; hydroxylamine O-sulfonic acid; monocarboxylic acid amide; ureas	antibacterial drug; antimicrobial agent; EC 3.5.2.6 (beta-lactamase) inhibitor
prolylvaline Val-Pro : A dipeptide formed from L-valine and L-proline residues.	2.06	1	0	dipeptide	metabolite
tapentadol Tapentadol: An opioid analgesic, MU OPIOID RECEPTOR agonist, and noradrenaline reuptake inhibitor that is used in the treatment of moderate to severe pain, and of pain associated with DIABETIC NEUROPATHIES.	3.23	1	0	alkylbenzene
bb-83698 BB-83698: peptide deformylase inhibitor	2.04	1	0
valnemulin [no description available]	2.05	1	0
gambogic acid gambogic acid: RN given refers to (1R-(1alpha,1(Z),3abeta,5alpha,11beta,14aS*))-isomer	2.13	1	0	pyranoxanthones	metabolite
ppi-0903 ceftaroline : A cephalosporin that is the active metabolite of the prodrug ceftaroline fosamil. Used for the treatment of adults with acute bacterial skin and skin structure infections.	3.61	8	0	1,3-thiazoles; cephalosporin; iminium betaine; organic phosphoramidate; oxime O-ether; thiadiazoles	antibacterial drug; antimicrobial agent; prodrug
pentagastrin Pentagastrin: A synthetic pentapeptide that has effects like gastrin when given parenterally. It stimulates the secretion of gastric acid, pepsin, and intrinsic factor, and has been used as a diagnostic aid.	3.23	1	0	organic molecular entity
cefditoren cefditoren: structure given in first source; RN given refers to the (6R-(3(Z),6alpha,7beta(Z)))-isomer. cefditoren : A broad spectrum, third-generation cephalosporin antibiotic with (Z)-2-(4-methyl-1,3-thiazol-5-yl)ethenyl and (2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetamido groups at positions 3 and 7, respectively, of the cephem skeleton. Generally administered as its orally absorbed pivaloyloxymethyl ester prodrug, it is used for the treatment of mild to moderate infections caused by susceptible strains of microorganisms in acute bacterial exacerbation of chronic bronchitis, community-acquired pneumonia, pharyngitis/tonsillitis, and uncomplicated skin and skin-structure infections.	3.23	1	0	carboxylic acid; cephalosporin	antibacterial drug
zotarolimus zotarolimus: synthetic analog of rapamycin; structure in first source	2.04	1	0	lactam; macrolide
treosulfan treosulfan: immunosuppressant; RN given refers to (S-(R,R))-isomer	2.04	1	0	methanesulfonate ester
sucrose monolaurate sucrose monolaurate: RN given refers to monolaurate	2.15	1	0
gentamicin sulfate [no description available]	6	25	1
bn 52020 [no description available]	2.04	1	0
nkp 608 [no description available]	2.04	1	0
isoleucyl-prolyl-proline [no description available]	2.02	1	0	oligopeptide
ganu GANU: differs from chlorozotocin by placement of cytotoxic group on C-1 of the glucose ring; less myelosuppressive than chlorozotocin; structure	2.04	1	0
pazopanib pazopanib: a protein kinase inhibitor. pazopanib : A pyrimidine that is 5-(pyrimidin-2-yl}amino-2-methylbenzenesulfonamide substituted at position 4 by a (2,3-dimethylindazol-6-yl)(methyl)amino group. Used as its hydrochloride salt for treatment of kidney cancer.	3.23	1	0	aminopyrimidine; indazoles; sulfonamide	angiogenesis modulating agent; antineoplastic agent; tyrosine kinase inhibitor; vascular endothelial growth factor receptor antagonist
prasugrel hydrochloride Prasugrel Hydrochloride: A piperazine derivative and PLATELET AGGREGATION INHIBITOR that is used to prevent THROMBOSIS in patients with ACUTE CORONARY SYNDROME; UNSTABLE ANGINA and MYOCARDIAL INFARCTION, as well as in those undergoing PERCUTANEOUS CORONARY INTERVENTIONS.. prasugrel hydrochloride : A racemate comprising equal amounts of (R)- and (S)-prasugrel hydrochloride. Used to prevent blood clots in people with acute coronary syndrome who are undergoing a procedure after a recent heart attack or stroke, and in people with certain disorders of the heart or blood vessels.	3.23	1	0
besifloxacin [no description available]	2.05	1	0	quinolines
oxadiazoles Oxadiazoles: Compounds containing five-membered heteroaromatic rings containing two carbons, two nitrogens, and one oxygen atom which exist in various regioisomeric forms.	2.38	2	0
baci-im [no description available]	4.54	7	0	homodetic cyclic peptide; polypeptide; zwitterion	antibacterial agent; antimicrobial agent
ribose ribopyranose : The pyranose form of ribose.	1.94	1	0	D-ribose; ribopyranose
metamelfalan [no description available]	2.04	1	0
isoleucyl-valyl-tyrosine [no description available]	2.44	2	0	oligopeptide
polymyxin b(1) [no description available]	2.25	1	0
tedizolid DA 7157: an anti-infective agent; structure in first source. tedizolid : A member of the class of pyridines that is pyridine which is substituted by a 2-methyl-2H-tetrazol-5-yl group at position 2 and by a 2-fluoro-4-[(5R)-5-(hydroxymethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl group at position 5. It is used as its phosphate pro-drug used for the treatment of acute bacterial skin and skin structure infections caused by certain susceptible bacteria, including Staphylococcus aureus (including methicillin-resistant strains (MRSA) and methicillin-susceptible strains), various Streptococcus species, and Enterococcus faecalis.	2.45	2	0	carbamate ester; organofluorine compound; oxazolidinone; primary alcohol; pyridines; tetrazoles	antimicrobial agent; drug metabolite; protein synthesis inhibitor
bms 477118 [no description available]	3.23	1	0	adamantanes; azabicycloalkane; monocarboxylic acid amide; nitrile; tertiary alcohol	EC 3.4.14.5 (dipeptidyl-peptidase IV) inhibitor; hypoglycemic agent
nystatin a1 Nystatin: Macrolide antifungal antibiotic complex produced by Streptomyces noursei, S. aureus, and other Streptomyces species. The biologically active components of the complex are nystatin A1, A2, and A3.. nystatin : A heterogeneous mixture of polyene compounds produced by cultures of Streptomyces noursei. It mainly consists of three biologically active components designated nystatin A1, nystatin A2, and nystatin A3. It is used to treat oral and dermal fungal infections.. nystatin A1 : A polyene macrolide antibiotic; part of the nystatin complex produced by several Streptomyces species. It is an antifungal antibiotic used for the treatment of topical fungal infections caused by a broad spectrum of fungal pathogens comprising yeast-like and filamentous species.	4.87	11	0	nystatins
prolyl-proline Pro-Pro : A dipeptide formed from two L-proline residues.	2.02	1	0	dipeptide	human urinary metabolite; Mycoplasma genitalium metabolite
milnacipran [no description available]	3.23	1	0	acetamides
vindesine [no description available]	2.44	2	0
cefdinir Cefdinir: A third-generation oral cephalosporin antibacterial agent that is used to treat bacterial infections of the respiratory tract and skin.. cefdinir : A cephalosporin compound having 7beta-2-(2-amino-thiazol-4-yl)-2-[(Z)-hydroxyimino]-acetylamino- and 3-vinyl side groups.	2.4	2	0
ru 66647 telithromycin: a ketolide; semisynthetic derivative of erythromycin with cycling of the C11-12 positions to form a carbamate ring to avoid acquired resistance to macrolides; binds 70S bacterial rRNA, specifically to the 23S part (23S RIBOSOMAL RNA), preventing protein synthesis;	2.13	1	0
diflucortolone Diflucortolone: A topical glucocorticoid used in various DERMATOSES. It is absorbed through the skin, bound to plasma albumin, and may cause adrenal suppression. It is also administered as the valerate.	2.04	1	0	21-hydroxy steroid
scopolamine hydrobromide [no description available]	3.83	3	0
pituitrin Pituitrin: A substance or extract from the neurohypophysis (PITUITARY GLAND, POSTERIOR).	1.94	1	0
virginiamycin Virginiamycin: A cyclic polypeptide antibiotic complex from Streptomyces virginiae, S. loidensis, S. mitakaensis, S. pristina-spiralis, S. ostreogriseus, and others. It consists of 2 major components, VIRGINIAMYCIN FACTOR M1 and virginiamycin Factor S1. It is used to treat infections with gram-positive organisms and as a growth promoter in cattle, swine, and poultry.. virginiamycin : A mixture of cyclic polypeptide streptogramin antibiotics produced by Streptomyces virginiae, S. loidensis, S. mitakaensis, S. pristina-spiralis, S. ostreogriseus, and others. The two major components are virginiamycin M1 (also known as pristinamycin IIA) and virginiamycin S1. Virginiamycin has been widely used as a growth promotion agent in livestock and has been to have bacteriostatic activity against Gram-positive organisms such as staphylococci and streptococci.	6.36	15	3
rifamycins [no description available]	2.86	4	0
2-((3-chloroethyl)-3-nitrosoureido)glucopyranose [no description available]	2.04	1	0
ro 6-4563 glibornuride: was MH 1975-92 (see under SULFONYLUREA COMPOUNDS 1975-90); use SULFONYLUREA COMPOUNDS to search GLIBORNURIDE 1975-92; an oral, sulfonylurea hypoglycemic agent which stimulates insulin secretion	2.04	1	0	monoterpenoid
acid phosphatase Acid Phosphatase: An enzyme that catalyzes the conversion of an orthophosphoric monoester and water to an alcohol and orthophosphate. EC 3.1.3.2.	2.34	2	0
4,6-dibromo-2-(2',4'-dibromo)phenoxyanisole 4,6-dibromo-2-(2',4'-dibromo)phenoxyanisole: a brominated compound, detected in the blubber of dolphins and other marine mammals from Queensland (northeast Australia)	2.13	1	0
rwj-416457 RWJ-416457: pyrrolopyrazolyl-substituted oxazolidinone; structure in first source	2.03	1	0
ach 702 ACH 702: an anti-tubercular agent; structure in first source	2.06	1	0
forbesione forbesione: structure in first source	2.13	1	0
bisaramil [no description available]	2.04	1	0
melitten Melitten: Basic polypeptide from the venom of the honey bee (Apis mellifera). It contains 26 amino acids, has cytolytic properties, causes contracture of muscle, releases histamine, and disrupts surface tension, probably due to lysis of cell and mitochondrial membranes.	2.25	1	0
bivalirudin bivalirudin: designed to bind to the alpha-thrombin catalytic site and anion-binding exosite for fibrin(ogen) recognition. bivalirudin : A synthetic peptide of 20 amino acids, comprising D-Phe, Pro, Arg, Pro, Gly, Gly, Gly, Gly, Asn, Gly, Asp, Phe, Glu, Glu, Ile, Pro, Glu, Glu, Tyr, and Leu in sequence. A congener of hirudin (a naturally occurring drug found in the saliva of the medicinal leech), it a specific and reversible inhibitor of thrombin, and is used as an anticoagulant.	3.23	1	0	polypeptide	anticoagulant; EC 3.4.21.5 (thrombin) inhibitor
teicoplanin teicoplanin A2-1 : A teicoplanin A2 that has (4Z)-dec-4-enoyl as the variable N-acyl group.	2.45	2	0
enfuvirtide Enfuvirtide: A synthetic 36-amino acid peptide that corresponds to the heptad repeat sequence of HIV-1 gp41. It blocks HIV cell fusion and viral entry and is used with other anti-retrovirals for combination therapy of HIV INFECTIONS and AIDS.. enfuvirtide : A synthetic 36-amino acid peptide consisting of N-acetyltyrosyl, threonyl, seryl, leucyl, isoleucyl, histidyl, seryl, leucyl, isoleucyl, alpha-glutamyl, alpha-glutamyl, seryl, glutaminyl, asparaginyl, glutaminyl, glutaminyl, alpha-glutamyl, lysyl, asparaginyl, alpha-glutamyl, alpha-glutamyl, alpha-glutamyl, leucyl, leucyl, alpha-glutamyl, leucyl, alpha-aspartyl, lysyl, tryptophyl, alanyl, seryl, leucyl, tryptophyl, asparaginyl, tryptophyl, and phenylalaninamide residues joined in sequence. An HIV fusion inhibitor, it was the first of a novel class of antiretroviral drugs used in combination therapy for the treatment of HIV-1 infection. It interferes with entry of HIV into cells by binding to the gp41 sub-unit of the viral envelope glycoprotein, so inhibiting fusion of viral and cellular membranes.	3.23	1	0
ganirelix [no description available]	3.23	1	0	polypeptide
mbi-226 omiganan pentahydrochloride: a cationic peptide with antibacterial activity	2.02	1	0
teriparatide [no description available]	3.23	1	0	polypeptide
forapin Forapin: used as ointment for treatment of myositis & arthritis; contains bee venom, salicylate, nicotinate & vanillylnonamide	2.63	2	0	peptidyl amide; polypeptide	animal metabolite; antineoplastic agent; apoptosis inducer; EC 2.7.11.13 (protein kinase C) inhibitor; hepatoprotective agent; neuroprotective agent; venom
salmon calcitonin [no description available]	3.23	1	0	heterodetic cyclic peptide; peptide hormone; polypeptide	bone density conservation agent; metabolite
tannins Tannins: Polyphenolic compounds with molecular weights of around 500-3000 daltons and containing enough hydroxyl groups (1-2 per 100 MW) for effective cross linking of other compounds (ASTRINGENTS). The two main types are HYDROLYZABLE TANNINS and CONDENSED TANNINS. Historically, the term has applied to many compounds and plant extracts able to render skin COLLAGEN impervious to degradation. The word tannin derives from the Celtic word for OAK TREE which was used for leather processing.	2.44	2	0
ly-146032 [no description available]	5.5	20	0	heterodetic cyclic peptide; lipopeptide antibiotic; lipopeptide; macrocycle; macrolide	antibacterial drug; bacterial metabolite; calcium-dependent antibiotics
dalbavancin [no description available]	2.04	1	0	carbohydrate acid derivative; glycopeptide; monosaccharide derivative; semisynthetic derivative	antibacterial drug; antimicrobial agent
acetyl-2-naphthylalanyl-3-chlorophenylalanyl-1-oxohexadecyl-seryl-4-aminophenylalanyl(hydroorotyl)-4-aminophenylalanyl(carbamoyl)-leucyl-ilys-prolyl-alaninamide acetyl-2-naphthylalanyl-3-chlorophenylalanyl-1-oxohexadecyl-seryl-4-aminophenylalanyl(hydroorotyl)-4-aminophenylalanyl(carbamoyl)-leucyl-ILys-prolyl-alaninamide: FE-200486 is the acetate salt	3.23	1	0	polypeptide
oritavancin oritavancin : A semisynthetic glycopeptide used (as its bisphosphate salt) for the treatment of acute bacterial skin and skin structure infections caused or suspected to be caused by susceptible isolates of designated Gram-positive microorganisms including MRSA.	2.77	3	0	disaccharide derivative; glycopeptide; semisynthetic derivative	antibacterial drug; antimicrobial agent
exenatide [no description available]	3.23	1	0
ropocamptide ropocamptide: from granulocytes & keratinocytes, precursor to cathelicidins; MW 16-18 kDa; GenBank AJ224927 (eCATH-1). cathelicidin : A group of small, cationic polypeptides (consisting of 12-97 amino acids) that are found in humans and other species, including farm animals (E.g. cattle, horses, pigs, sheep etc). They show a broad spectrum of antimicrobial activity against bacteria, enveloped viruses and fungi.	2.21	1	0
ristocetin Ristocetin: An antibiotic mixture of two components, A and B, obtained from Nocardia lurida (or the same substance produced by any other means). It is no longer used clinically because of its toxicity. It causes platelet agglutination and blood coagulation and is used to assay those functions in vitro.. ristocetin : A heterodetic cyclic peptide that is produced by species of Amycolatopsis and Nocardia.	4.65	9	0	glycopeptide; heterodetic cyclic peptide; macrocycle; tetrasaccharide derivative	antibacterial drug; antimicrobial agent; bacterial metabolite; platelet-activating factor receptor agonist
ceftiofur ceftiofur: structure in first source	2.42	2	0
cefamandole nafate, monosodium salt, 14c-labeled, (6r-(6alpha,7beta,(r)))-isomer cefamandole nafate: RN given refers to (6R-(6alpha,7beta(R)))-isomer. cefamandole nafate : A cephalosporin prodrug having (R)-O-formylmandelamido and N-methylthiotetrazole side-groups.	1.97	1	0
flucloronide flucloronide: synthetic glucocorticoid with anti-inflammatory properties; minor descriptor (75-83); on-line & Index Medicus search PREGNADIENETROLS (75-83); RN given refers to (6alpha,11beta,16alpha)-isomer; structure	2.04	1	0	21-hydroxy steroid
chitosan [no description available]	2.13	1	0
mesna Mesna: A sulfhydryl compound used to prevent urothelial toxicity by inactivating metabolites from ANTINEOPLASTIC AGENTS, such as IFOSFAMIDE or CYCLOPHOSPHAMIDE.	3.23	1	0	organosulfonic acid
sodium lactate Sodium Lactate: The sodium salt of racemic or inactive lactic acid. It is a hygroscopic agent used intravenously as a systemic and urinary alkalizer.. sodium lactate : An organic sodium salt having lactate as the counterion.	3.23	1	0	lactate salt; organic sodium salt	food acidity regulator; food preservative
sodium iothalamate [no description available]	3.23	1	0
cephapirin sodium cephapirin sodium : The sodium salt of cephapirin. A first-generation cephalosporin antibiotic, it is effective against gram-negative and gram-positive organisms. Being more resistant to beta-lactamases than penicillins, it is effective agains most staphylococci, though not methicillin-resistant staphylococci.	2.06	1	0	cephalosporin; organic sodium salt	antibacterial drug
ro13-9904 Ceftriaxone: A broad-spectrum cephalosporin antibiotic and cefotaxime derivative with a very long half-life and high penetrability to meninges, eyes and inner ears.. ceftriaxone : A third-generation cephalosporin compound having 2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetylamino and [(2-methyl-5,6-dioxo-1,2,5,6-tetrahydro-1,2,4-triazin-3-yl)sulfanyl]methyl side-groups.	9.07	26	2
piperacillin, tazobactam drug combination Piperacillin, Tazobactam Drug Combination: An antibiotic combination product of piperacillin and tazobactam, a penicillanic acid derivative with enhanced beta-lactamase inhibitory activity, that is used for the intravenous treatment of intra-abdominal, pelvic, and skin infections and for community-acquired pneumonia of moderate severity. It is also used for the treatment of PSEUDOMONAS AERUGINOSA INFECTIONS.	2.97	4	0
quinupristin quinupristin: component of RP 59500; structure in first source	2.03	1	0	cyclodepsipeptide
quinupristin-dalfopristin quinupristin-dalfopristin: RP 59500 is a combination of RP 57669 & RP 54476, which are water soluble derivatives of pristinamycin IA & pristinamycin IIB, respectively	9.9	8	1	organic molecular entity
4,4-difluoro-4-bora-3a,4a-diaza-s-indacene [no description available]	2.08	1	0	BODIPY compound
cetrorelix cetrorelix: LHRH antagonist. cetrorelix : A synthetic ten-membered oligopeptide comprising N-acetyl-3-(naphthalen-2-yl)-D-alanyl, 4-chloro-D-phenylalanyl, 3-(pyridin-3-yl)-D-alanyl, L-seryl, L-tyrosyl, N(5)-carbamoyl-D-ornithyl, L-leucyl, L-arginyl, L-prolyl, and D-alaninamide residues coupled in sequence. A gonadotrophin-releasing hormone (GnRH) antagonist, it is used for treatment of infertility and of hormone-sensitive cancers of the prostate and breast.	3.58	2	0	oligopeptide	antineoplastic agent; GnRH antagonist
hainanolide hainanolide: from bark of Cephalotaxux hainensis	2.04	1	0
gliocladic acid gliocladic acid: from Gliocladium virens, Chaetomium globosum & Trichoderma viride; structure given in first source	2.04	1	0	p-menthane monoterpenoid
glycolipids [no description available]	2.07	1	0
cleistanthin cleistanthin: lignan lactone toxic glycoside from Cleistanthus collinus (Roxb); structure. cleistanthin A : A member of the class of cleistanthins that is the 4-O-3,4-di-O-methyl-beta-D-xylopyranoside of 1,3-dihydronaphtho[2,3-c]furan-4-ol which is substituted by an oxo group at position 1, methoxy groups at positions 6 and 7, and a 1,3-benzodioxol-5-yl group at position 9. It is one of the toxic principles in Cleistanthus collinus.	2.04	1	0	cleistanthins; xylose derivative	alpha-adrenergic antagonist; antihypertensive agent; diuretic
punicalagin punicalagin: hepatoprotective agent isolated from Terminalia catappa; structure in first source	7.17	1	0	tannin
colistin Colistin: Cyclic polypeptide antibiotic from Bacillus colistinus. It is composed of Polymyxins E1 and E2 (or Colistins A, B, and C) which act as detergents on cell membranes. Colistin is less toxic than Polymyxin B, but otherwise similar; the methanesulfonate is used orally.. colistin : A multi-component mixture comprising mostly of colistin A (R = Me) and B (R = H), with small amounts of colistin C and other polymyxins, produced by certain strains of Bacillus polymyxa var. colistinus. An antibiotic, it is used as its sulfate salt (for oral or topical use) or as the sodium salt of the N-methylsulfonic acid derivative (the injectable form) in the treatment of severe Gram-negative infections, partiularly those due to Pseudomonas aeruginosa.	12.48	45	0
tylosin [no description available]	2.41	1	0
nimorazole [no description available]	2.04	1	0
methylcellulose Methylcellulose: Methylester of cellulose. Methylcellulose is used as an emulsifying and suspending agent in cosmetics, pharmaceutics and the chemical industry. It is used therapeutically as a bulk laxative.	1.94	1	0
bocillin fl BOCILLIN FL: used for detecting pencillin-binding proteins; structure in first source	2.44	2	0
chondroitin Chondroitin: A mucopolysaccharide constituent of chondrin. (Grant & Hackh's Chemical Dictionary, 5th ed)	1.94	1	0
caffeinol caffeinol: has neuroprotective effects	2.03	1	0
ascorbic acid Ascorbic Acid: A six carbon compound related to glucose. It is found naturally in citrus fruits and many vegetables. Ascorbic acid is an essential nutrient in human diets, and necessary to maintain connective tissue and bone. Its biologically active form, vitamin C, functions as a reducing agent and coenzyme in several metabolic pathways. Vitamin C is considered an antioxidant.. L-ascorbic acid : The L-enantiomer of ascorbic acid and conjugate acid of L-ascorbate.. L-ascorbate : The L-enantiomer of ascorbate and conjugate base of L-ascorbic acid, arising from selective deprotonation of the 3-hydroxy group. Required for a range of essential metabolic reactions in all animals and plants.. vitamin C : Any member of a group of vitamers that belong to the chemical structural class called butenolides that exhibit biological activity against vitamin C deficiency in animals. The vitamers include L-ascorbic acid and its salt, ionized and oxidized forms.	4.16	5	0	ascorbic acid; vitamin C	coenzyme; cofactor; flour treatment agent; food antioxidant; food colour retention agent; geroprotector; plant metabolite; skin lightening agent
raltegravir [no description available]	3.23	1	0	1,2,4-oxadiazole; dicarboxylic acid amide; hydroxypyrimidine; monofluorobenzenes; pyrimidone; secondary carboxamide	antiviral drug; HIV-1 integrase inhibitor
coumermycin coumermycin: RN given refers to coumermycin A1; structure. coumermycin A1 : A hydroxycoumarin antibiotic that is obtained from Streptomyces rishiriensis and exhibits potent antibacterial and anticancer activity.	1.97	1	0	aromatic amide; coumarins; glycoside; heteroarenecarboxylate ester; pyrroles	antimicrobial agent; antineoplastic agent; bacterial metabolite; DNA synthesis inhibitor; Hsp90 inhibitor; topoisomerase IV inhibitor
novobiocin Novobiocin: An antibiotic compound derived from Streptomyces niveus. It has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, and blocks adenosine triphosphatase (ATPase) activity. (From Reynolds, Martindale The Extra Pharmacopoeia, 30th ed, p189). novobiocin : A coumarin-derived antibiotic obtained from Streptomyces niveus.	6.05	39	0	carbamate ester; ether; hexoside; hydroxycoumarin; monocarboxylic acid amide; monosaccharide derivative; phenols	antibacterial agent; antimicrobial agent; EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor; Escherichia coli metabolite; hepatoprotective agent
tetracycline Tetracycline: A naphthacene antibiotic that inhibits AMINO ACYL TRNA binding during protein synthesis.. tetracycline : A broad-spectrum polyketide antibiotic produced by the Streptomyces genus of actinobacteria.	9.07	187	0
chlortetracycline Chlortetracycline: A TETRACYCLINE with a 7-chloro substitution.. chlortetracycline : A member of the class of tetracyclines with formula C22H23ClN2O8 isolated from Streptomyces aureofaciens.	10.19	16	0
oxytetracycline, anhydrous Oxytetracycline: A TETRACYCLINE analog isolated from the actinomycete STREPTOMYCES RIMOSUS and used in a wide variety of clinical conditions.. oxytetracycline : A tetracycline used for treatment of infections caused by a variety of Gram positive and Gram negative microorganisms including Mycoplasma pneumoniae, Pasteurella pestis, Escherichia coli, Haemophilus influenzae (respiratory infections), and Diplococcus pneumoniae.	7.08	27	1
minocycline Minocycline: A TETRACYCLINE analog, having a 7-dimethylamino and lacking the 5 methyl and hydroxyl groups, which is effective against tetracycline-resistant STAPHYLOCOCCUS infections.. minocycline : A tetracycline analogue having a dimethylamino group at position 7 and lacking the methyl and hydroxy groups at position 5.	10.33	17	0
methacycline Methacycline: A broad-spectrum semisynthetic antibiotic related to TETRACYCLINE but excreted more slowly and maintaining effective blood levels for a more extended period.. methacycline : A tetracycline that is the 6-methylene analogue of oxytetracycline, obtained by formal dehydration at position 6.	3.2	6	0
salicylates Salicylates: The salts or esters of salicylic acids, or salicylate esters of an organic acid. Some of these have analgesic, antipyretic, and anti-inflammatory activities by inhibiting prostaglandin synthesis.. hydroxybenzoate : Any benzoate derivative carrying a single carboxylate group and at least one hydroxy substituent.. salicylates : Any salt or ester arising from reaction of the carboxy group of salicylic acid, or any ester resulting from the condensation of the phenolic hydroxy group of salicylic acid with an organic acid.. salicylate : A monohydroxybenzoate that is the conjugate base of salicylic acid.	1.94	1	0	monohydroxybenzoate	plant metabolite
dicumarol Dicumarol: An oral anticoagulant that interferes with the metabolism of vitamin K. It is also used in biochemical experiments as an inhibitor of reductases.	1.95	1	0	hydroxycoumarin	anticoagulant; EC 1.6.5.2 [NAD(P)H dehydrogenase (quinone)] inhibitor; Hsp90 inhibitor; vitamin K antagonist
piroxicam [no description available]	3.23	1	0	benzothiazine; monocarboxylic acid amide; pyridines	analgesic; antirheumatic drug; cyclooxygenase 1 inhibitor; EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor; non-steroidal anti-inflammatory drug
roquinimex roquinimex: structure in first source	2.04	1	0	aromatic amide
bactobolin bactobolin: from Pseudomonas sp. BN-183; has MF C14-H20-Cl2-N2-O6; RN given refers to parent cpd(R*)-isomer	2.04	1	0	amino acid amide
mobic Meloxicam: A benzothiazine and thiazole derivative that acts as a NSAID and cyclooxygenase-2 (COX-2) inhibitor. It is used in the treatment of RHEUMATOID ARTHRITIS; OSTEOARTHRITIS; and ANKYLOSING SPONDYLITIS.. meloxicam : A benzothiazine that is piroxicam in which the pyridin-2-yl group is replaced by a 5-methyl-1,3-thiazol-2-yl group. A non-steroidal anti-inflammatory drug and selective inhibitor of COX-2, it is used particularly for the management of rheumatoid arthritis.	3.85	3	0	1,3-thiazoles; benzothiazine; monocarboxylic acid amide	analgesic; antirheumatic drug; cyclooxygenase 2 inhibitor; non-steroidal anti-inflammatory drug
mobiflex tenoxicam : A thienothiazine-derived monocarboxylic acid amide obtained by formal condensation of the carboxy group of 4-hydroxy-2-methylthieno[2,3-e][1,2]thiazine-3-carboxylic acid 1,1-dioxide with the amino group of 2-aminopyridine. Used for the treatment of pain and inflammation in osteoarthritis and rheumatoid arthritis. It is also indicated for short term treatment of acute musculoskeletal disorders including strains, sprains and other soft-tissue injuries.	2.94	4	0	heteroaryl hydroxy compound; monocarboxylic acid amide; pyridines; thienothiazine	antipyretic; EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor; non-narcotic analgesic; non-steroidal anti-inflammatory drug
isoxicam isoxicam : A monocarboxylic acid amide that is piroxicam in which the pyrid-2-yl group is replaced by a 5-methyl-1,2-oxazol-3-yl group. A non-steroidal anti-inflammatory drug, it was withdrawn from the market in the 1980s following its association with cases of Stevens-Johnson syndrome.	2.45	2	0	benzothiazine; isoxazoles; monocarboxylic acid amide	antirheumatic drug; non-steroidal anti-inflammatory drug
warfarin Warfarin: An anticoagulant that acts by inhibiting the synthesis of vitamin K-dependent coagulation factors. Warfarin is indicated for the prophylaxis and/or treatment of venous thrombosis and its extension, pulmonary embolism, and atrial fibrillation with embolization. It is also used as an adjunct in the prophylaxis of systemic embolism after myocardial infarction. Warfarin is also used as a rodenticide.. warfarin : A racemate comprising equal amounts of (R)- and (S)-warfarin. Extensively used as both an anticoagulant drug and as a pesticide against rats and mice.. 4-hydroxy-3-(3-oxo-1-phenylbutyl)-1-benzopyran-2-one : A member of the class of coumarins that is 4-hydroxycoumarin which is substituted at position 3 by a 1-phenyl-3-oxo-1-butyl group.	4.98	7	0	benzenes; hydroxycoumarin; methyl ketone
demeclocycline Demeclocycline: A TETRACYCLINE analog having a 7-chloro and a 6-methyl. Because it is excreted more slowly than tetracycline, it maintains effective blood levels for longer periods of time.. demeclocycline : Tetracycline which lacks the methyl substituent at position 7 and in which the hydrogen para- to the phenolic hydroxy group is substituted by chlorine. Like tetracycline, it is an antibiotic, but being excreted more slowly, effective blood levels are maintained for longer. It is used (mainly as the hydrochloride) for the treatment of Lyme disease, acne and bronchitis, as well as for hyponatraemia (low blood sodium concentration) due to the syndrome of inappropriate antidiuretic hormone (SIADH) where fluid restriction alone has been ineffective.	4.83	6	0
tipranavir tipranavir: inhibits HIV-1 protease. tipranavir : A pyridine-2-sulfonamide substituted at C-5 by a trifluoromethyl group and at the sulfonamide nitrogen by a dihydropyrone-containing m-tolyl substituent. It is an HIV-1 protease inhibitor.	3.23	1	0	sulfonamide	antiviral drug; HIV protease inhibitor
rolitetracycline Rolitetracycline: A pyrrolidinylmethyl TETRACYCLINE.. rolitetracycline : A derivative of tetracycline in which the amide function is substituted with a pyrrolidinomethyl group.	2.04	1	0
tigecycline [no description available]	10.12	13	0
rpx7009 RPX7009: a beta-lactamase inhibitor; structure in first source	2.25	1	0
optocillin optocillin: combination of mezlocillin & oxacillin	5.41	8	2
brine brine: not from seawater; contains sodium chloride; calcium chloride; magnesium chloride; one or all of the above	2.21	1	0
ajmaline [no description available]	2	1	0
agar Agar: A complex sulfated polymer of galactose units, extracted from Gelidium cartilagineum, Gracilaria confervoides, and related red algae. It is used as a gel in the preparation of solid culture media for microorganisms, as a bulk laxative, in making emulsions, and as a supporting medium for immunodiffusion and immunoelectrophoresis.. agar : A complex mixture of polysaccharides extracted from species of red algae. Its two main components are agarose and agaropectin. Agarose is the component responsible for the high-strength gelling properties of agar, while agaropectin provides the viscous properties.	4.92	36	0
fertinex [no description available]	3.23	1	0
indolicidin [no description available]	7.04	1	0
hyaluronoglucosaminidase Hyaluronoglucosaminidase: An enzyme that catalyzes the random hydrolysis of 1,4-linkages between N-acetyl-beta-D-glucosamine and D-glucuronate residues in hyaluronate. (From Enzyme Nomenclature, 1992) There has been use as ANTINEOPLASTIC AGENTS to limit NEOPLASM METASTASIS.	1.93	1	0
daptomycin [no description available]	5.01	38	0
chloroorienticin a chloroorienticin A: structure given in first source; isolated from Amycolatopsis orientalis	1.97	1	0
dalfopristin dalfopristin: component of RP-59500; structure in first source. dalfopristin : A macrolide that is pristinamycin IIA in which the double bond between positions 26 and 26a of the pyrroline ring has been reduced and position 26R carries a [2-(diethylamino)ethyl]sulfonyl group. It is a semi-synthetic streptogramin antibiotic and often used as a mixture with quinupristin for the treatment of vancomycin-resistant Enterococcus faecium.	2.03	1	0
silybin Silybin: The major active component of silymarin flavonoids extracted from seeds of the MILK THISTLE, Silybum marianum; it is used in the treatment of HEPATITIS; LIVER CIRRHOSIS; and CHEMICAL AND DRUG INDUCED LIVER INJURY, and has antineoplastic activity; silybins A and B are diastereomers.	2.06	1	0
technetium tc 99m medronate Technetium Tc 99m Medronate: A gamma-emitting radionuclide imaging agent used primarily in skeletal scintigraphy. Because of its absorption by a variety of tumors, it is useful for the detection of neoplasms.	2.05	1	0
muramidase Muramidase: A basic enzyme that is present in saliva, tears, egg white, and many animal fluids. It functions as an antibacterial agent. The enzyme catalyzes the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrin. EC 3.2.1.17.	3.34	7	0
cord factors Cord Factors: Toxic glycolipids composed of trehalose dimycolate derivatives. They are produced by MYCOBACTERIUM TUBERCULOSIS and other species of MYCOBACTERIUM. They induce cellular dysfunction in animals.	2.39	2	0
exudates Malaysia: A parliamentary democracy with a constitutional monarch in southeast Asia, consisting of 11 states (West Malaysia) on the Malay Peninsula and two states (East Malaysia) on the island of BORNEO. It is also called the Federation of Malaysia. Its capital is Kuala Lumpur. Before 1963 it was the Union of Malaya. It reorganized in 1948 as the Federation of Malaya, becoming independent from British Malaya in 1957 and becoming Malaysia in 1963 as a federation of Malaya, Sabah, Sarawak, and Singapore (which seceded in 1965). The form Malay- probably derives from the Tamil malay, mountain, with reference to its geography. (From Webster's New Geographical Dictionary, 1988, p715 & Room, Brewer's Dictionary of Names, 1992, p329)	2.02	1	0
pyridomycin pyridomycin: extract of Streptomyces	2.41	1	0
entecavir entecavir (anhydrous) : Guanine substituted at the 9 position by a 4-hydroxy-3-(hydroxymethyl)-2-methylidenecyclopentyl group. A synthetic analogue of 2'-deoxyguanosine, it is a nucleoside reverse transcriptase inhibitor with selective antiviral activity against hepatitis B virus. Entecavir is phosphorylated intracellularly to the active triphosphate form, which competes with deoxyguanosine triphosphate, the natural substrate of hepatitis B virus reverse transcriptase, inhibiting every stage of the enzyme's activity, although it has no activity against HIV. It is used for the treatment of chronic hepatitis B.	3.23	1	0	2-aminopurines; oxopurine; primary alcohol; secondary alcohol	antiviral drug; EC 2.7.7.49 (RNA-directed DNA polymerase) inhibitor
acyclovir Acyclovir: A GUANOSINE analog that acts as an antimetabolite. Viruses are especially susceptible. Used especially against herpes.. acyclovir : An oxopurine that is guanine substituted by a (2-hydroxyethoxy)methyl substituent at position 9. Used in the treatment of viral infections.	4.07	4	0	2-aminopurines; oxopurine	antimetabolite; antiviral drug
cyclic gmp Cyclic GMP: Guanosine cyclic 3',5'-(hydrogen phosphate). A guanine nucleotide containing one phosphate group which is esterified to the sugar moiety in both the 3'- and 5'-positions. It is a cellular regulatory agent and has been described as a second messenger. Its levels increase in response to a variety of hormones, including acetylcholine, insulin, and oxytocin and it has been found to activate specific protein kinases. (From Merck Index, 11th ed). 3',5'-cyclic GMP : A 3',5'-cyclic purine nucleotide in which the purine nucleobase is specified as guanidine.	1.96	1	0	3',5'-cyclic purine nucleotide; guanyl ribonucleotide	Escherichia coli metabolite; human metabolite; mouse metabolite; plant metabolite; Saccharomyces cerevisiae metabolite
guanosine triphosphate Guanosine Triphosphate: Guanosine 5'-(tetrahydrogen triphosphate). A guanine nucleotide containing three phosphate groups esterified to the sugar moiety.	1.96	1	0	guanosine 5'-phosphate; purine ribonucleoside 5'-triphosphate	Escherichia coli metabolite; mouse metabolite; uncoupling protein inhibitor
guanine [no description available]	2.17	1	0	2-aminopurines; oxopurine; purine nucleobase	algal metabolite; Escherichia coli metabolite; human metabolite; mouse metabolite; Saccharomyces cerevisiae metabolite
folic acid folcysteine: used to promote fertility in chickens. vitamin B9 : Any B-vitamin that exhibits biological activity against vitamin B9 deficiency. Vitamin B9 refers to the many forms of folic acid and its derivatives, including tetrahydrofolic acid (the active form), methyltetrahydrofolate (the primary form found in blood), methenyltetrahydrofolate, folinic acid amongst others. They are present in abundance in green leafy vegetables, citrus fruits, and animal products. Lack of vitamin B9 leads to anemia, a condition in which the body cannot produce sufficient number of red blood cells. Symptoms of vitamin B9 deficiency include fatigue, muscle weakness, and pale skin.	3.23	1	0	folic acids; N-acyl-amino acid	human metabolite; mouse metabolite; nutrient
rifampin Rifampin: A semisynthetic antibiotic produced from Streptomyces mediterranei. It has a broad antibacterial spectrum, including activity against several forms of Mycobacterium. In susceptible organisms it inhibits DNA-dependent RNA polymerase activity by forming a stable complex with the enzyme. It thus suppresses the initiation of RNA synthesis. Rifampin is bactericidal, and acts on both intracellular and extracellular organisms. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p1160)	10.95	87	3	cyclic ketal; hydrazone; N-iminopiperazine; N-methylpiperazine; rifamycins; semisynthetic derivative; zwitterion	angiogenesis inhibitor; antiamoebic agent; antineoplastic agent; antitubercular agent; DNA synthesis inhibitor; EC 2.7.7.6 (RNA polymerase) inhibitor; Escherichia coli metabolite; geroprotector; leprostatic drug; neuroprotective agent; pregnane X receptor agonist; protein synthesis inhibitor
clozapine Clozapine: A tricylic dibenzodiazepine, classified as an atypical antipsychotic agent. It binds several types of central nervous system receptors, and displays a unique pharmacological profile. Clozapine is a serotonin antagonist, with strong binding to 5-HT 2A/2C receptor subtype. It also displays strong affinity to several dopaminergic receptors, but shows only weak antagonism at the dopamine D2 receptor, a receptor commonly thought to modulate neuroleptic activity. Agranulocytosis is a major adverse effect associated with administration of this agent.. clozapine : A benzodiazepine that is 5H-dibenzo[b,e][1,4]diazepine substituted by a chloro group at position 8 and a 4-methylpiperazin-1-yl group at position 11. It is a second generation antipsychotic used in the treatment of psychiatric disorders like schizophrenia.	4.06	4	0	benzodiazepine; N-arylpiperazine; N-methylpiperazine; organochlorine compound	adrenergic antagonist; dopaminergic antagonist; EC 3.4.21.26 (prolyl oligopeptidase) inhibitor; environmental contaminant; GABA antagonist; histamine antagonist; muscarinic antagonist; second generation antipsychotic; serotonergic antagonist; xenobiotic
dacarbazine (E)-dacarbazine : A dacarbazine in which the N=N double bond adopts a trans-configuration.	3.85	3	0	dacarbazine
didanosine Didanosine: A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by a hydrogen. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. Didanosine is a potent inhibitor of HIV replication, acting as a chain-terminator of viral DNA by binding to reverse transcriptase; ddI is then metabolized to dideoxyadenosine triphosphate, its putative active metabolite.. didanosine : A purine 2',3'-dideoxyribonucleoside that is inosine in which the hydroxy groups at both the 2' and the 3' positions on the sugar moiety have been replaced by hydrogen. An antiviral drug, it is used as a medication to treat HIV/AIDS.	3.85	3	0	purine 2',3'-dideoxyribonucleoside	antimetabolite; antiviral drug; EC 2.4.2.1 (purine-nucleoside phosphorylase) inhibitor; geroprotector; HIV-1 reverse transcriptase inhibitor
ganciclovir [no description available]	9.24	5	0	2-aminopurines; oxopurine	antiinfective agent; antiviral drug
valacyclovir Valacyclovir: A prodrug of acyclovir that is used in the treatment of HERPES ZOSTER and HERPES SIMPLEX VIRUS INFECTION of the skin and mucous membranes, including GENITAL HERPES.	3.23	1	0	L-valyl ester	antiviral drug
sildenafil sildenafil : A pyrazolo[4,3-d]pyrimidin-7-one having a methyl substituent at the 1-position, a propyl substituent at the 3-position and a 2-ethoxy-5-[(4-methylpiperazin-1-yl)sulfonyl]phenyl group at the 5-position.	3.85	3	0	piperazines; pyrazolopyrimidine; sulfonamide	EC 3.1.4.35 (3',5'-cyclic-GMP phosphodiesterase) inhibitor; vasodilator agent
olanzapine Olanzapine: A benzodiazepine derivative that binds SEROTONIN RECEPTORS; MUSCARINIC RECEPTORS; HISTAMINE H1 RECEPTORS; ADRENERGIC ALPHA-1 RECEPTORS; and DOPAMINE RECEPTORS. It is an antipsychotic agent used in the treatment of SCHIZOPHRENIA; BIPOLAR DISORDER; and MAJOR DEPRESSIVE DISORDER; it may also reduce nausea and vomiting in patients undergoing chemotherapy.. olanzapine : A benzodiazepine that is 10H-thieno[2,3-b][1,5]benzodiazepine substituted by a methyl group at position 2 and a 4-methylpiperazin-1-yl group at position 4.	3.54	2	0	benzodiazepine; N-arylpiperazine; N-methylpiperazine	antiemetic; dopaminergic antagonist; histamine antagonist; muscarinic antagonist; second generation antipsychotic; serotonergic antagonist; serotonin uptake inhibitor
penciclovir penciclovir : A member of the class of 2-aminopurines that is guanine in which the hydrogen at position 9 is substituted by a 4-hydroxy-3-(hydroxymethyl)but-1-yl group. An antiviral drug, it is administered topically for treatment of herpes labialis. A prodrug, famciclovir, is used for oral administration.	2.45	2	0	2-aminopurines; propane-1,3-diols	antiviral drug
vardenafil vardenafil : The sulfonamide resulting from formal condensation of the sulfo group of 4-ethoxy-3-(5-methyl-7-propylimidazo[5,1-f][1,2,4]triazin-4(1H)-one-2-yl)benzenesulfonic acid and the secondary amino group of 4-ethylpiperazine.	3.85	3	0	imidazotriazine; N-alkylpiperazine; N-sulfonylpiperazine	EC 3.1.4.* (phosphoric diester hydrolase) inhibitor; vasodilator agent
allopurinol Allopurinol: A XANTHINE OXIDASE inhibitor that decreases URIC ACID production. It also acts as an antimetabolite on some simpler organisms.. allopurinol : A bicyclic structure comprising a pyrazole ring fused to a hydroxy-substituted pyrimidine ring.	4.24	5	0	nucleobase analogue; organic heterobicyclic compound	antimetabolite; EC 1.17.3.2 (xanthine oxidase) inhibitor; gout suppressant; radical scavenger
azaguanine Azaguanine: One of the early purine analogs showing antineoplastic activity. It functions as an antimetabolite and is easily incorporated into ribonucleic acids.. 8-azaguanine : A triazolopyrimidine that consists of 3,6-dihydro-7H-[1,2,3]triazolo[4,5-d]pyrimidine bearing amino and oxo substituents at positions 5 and 7 respectively.	2.04	1	0	nucleobase analogue; triazolopyrimidines	antimetabolite; antineoplastic agent; EC 2.4.2.1 (purine-nucleoside phosphorylase) inhibitor
citrovorum factor [no description available]	3.23	1	0	tetrahydrofolic acid
leucovorin 5-formyltetrahydrofolic acid : A formyltetrahydrofolic acid in which the formyl group is located at position 5.	3.85	3	0	formyltetrahydrofolic acid	Escherichia coli metabolite; mouse metabolite
rifapentine rifapentine: cyclopentyl derivative of rifampicin	3.23	1	0	N-alkylpiperazine; N-iminopiperazine; rifamycins	antitubercular agent; leprostatic drug
alanosine [no description available]	2.04	1	0
bl 4162a anagrelide: imidazoquinazoline derivative which lowers platelet count probably by inhibiting thrombopoiesis and reduces platelet aggregation; used for thrombocythemia; structure in first source. anagrelide : A 1,5-dihydroimidazo[2,1-]quinazoline having an oxo substituent at the 2-position and chloro substituents at the 6- and 7-positions.	3.23	1	0	imidazoquinazoline	anticoagulant; antifibrinolytic drug; cardiovascular drug; platelet aggregation inhibitor
tegaserod tegaserod: a nonbenzamide 5-hydroxytryptamine(4) agonist; used in treatment of irritable bowel syndrome; marketing suspended 2007 in US due to higher incidence of MI, stroke, and unstable angina; structure given in first source	3.85	3	0	carboxamidine; guanidines; hydrazines; indoles	gastrointestinal drug; serotonergic agonist
pemetrexed pemetrexed disodium : An organic sodium salt that is the disodium salt of N-{4-[2-(2-amino-4-oxo-4,7-dihydro-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl}-L-glutamic acid. Inhibits thymidylate synthase (TS), 421 dihydrofolate reductase (DHFR), and glycinamide ribonucleotide formyltransferase (GARFT).	3.23	1	0	N-acyl-L-glutamic acid; pyrrolopyrimidine	antimetabolite; antineoplastic agent; EC 1.5.1.3 (dihydrofolate reductase) inhibitor; EC 2.1.1.45 (thymidylate synthase) inhibitor; EC 2.1.2.2 (phosphoribosylglycinamide formyltransferase) inhibitor
7-deazaguanosine 7-deazaguanosine: structure given in first source	2.04	1	0
tirapazamine Tirapazamine: A triazine derivative that introduces breaks into DNA strands in hypoxic cells, sensitizing tumor cells to the cytotoxic activity of other drugs and radiation.. tirapazamine : A member of the class of benzotriazines that is 1,2,4-benzotriazine carrying an amino substituent at position 3 and two oxido substituents at positions 1 and 4.	2.04	1	0	aromatic amine; benzotriazines; N-oxide	antibacterial agent; antineoplastic agent; apoptosis inducer
valganciclovir Valganciclovir: A ganciclovir prodrug and antiviral agent that is used to treat CYTOMEGALOVIRUS RETINITIS in patients with AIDS, and for the prevention of CYTOMEGALOVIRUS INFECTIONS in organ transplant recipients who have received an organ from a CMV-positive donor.. valganciclovir : The L-valinyl ester of ganciclovir, into which it is rapidly converted by intestinal and hepatic esterases. It is a synthetic analogue of 2'-deoxyguanosine.	3.23	1	0	L-valyl ester; purines	antiviral drug; prodrug
aprepitant Aprepitant: A morpholine neurokinin-1 (NK1) receptor antagonist that is used in the management of nausea and vomiting caused by DRUG THERAPY, and for the prevention of POSTOPERATIVE NAUSEA AND VOMITING.. aprepitant : A morpholine-based antiemetic, which is or the prevention of acute and delayed nausea and vomiting associated with initial and repeat courses of highly emetogenic cancer chemotherapy. Aprepitant is a selective high-affinity antagonist of human substance P/neurokinin 1 (NK1) receptors.	3.58	2	0	(trifluoromethyl)benzenes; cyclic acetal; morpholines; triazoles	antidepressant; antiemetic; neurokinin-1 receptor antagonist; peripheral nervous system drug; substance P receptor antagonist
fosaprepitant fosaprepitant: a pro-drug form of aprepitant. fosaprepitant : A morpholine derivative that is the (1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl ether of (3-{[(2R,3S)-3-(4-fluorophenyl)-2-hydroxymorpholin-4-yl]methyl}-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl)phosphonic acid.	3.23	1	0	(trifluoromethyl)benzenes; cyclic acetal; morpholines; phosphoramide; triazoles	antiemetic; neurokinin-1 receptor antagonist; prodrug
ceftobiprole ceftobiprole: BAL5788 is Ceftobiprole medocaril sodium. ceftobiprole : A fifth-generation cephalosporin antibiotic having (E)-[(3'R)-2-oxo[1,3'-bipyrrolidin]-3-ylidene]methyl and [(2Z)-2-(5-amino-1,2,4-thiadiazol-3-yl)-2-(hydroxyimino)acetyl]amino side groups located at positions 3 and 7 respectively; developed for the treatment of hospital-acquired pneumonia (HAP, excluding ventilator-associated pneumonia, VAP) and community-acquired pneumonia (CAP).	4.81	7	1	cephalosporin; thiadiazoles	antimicrobial agent
pyrazofurin pirazofurin : A C-glycosyl compound that is 4-hydroxy-1H-pyrazole-5-carboxamide in which the hydrogen at position 3 has been replaced by a beta-D-ribofuranosyl group.	2.04	1	0	C-glycosyl compound; pyrazoles	antimetabolite; antimicrobial agent; antineoplastic agent; EC 4.1.1.23 (orotidine-5'-phosphate decarboxylase) inhibitor
rifabutin [no description available]	3.85	3	0
n(10)-methylfolate [no description available]	2.04	1	0	folic acids
methylnitronitrosoguanidine Methylnitronitrosoguanidine: A nitrosoguanidine derivative with potent mutagenic and carcinogenic properties.. N-methyl-N'-nitro-N-nitrosoguanidine : An N-nitroguanidine compound having nitroso and methyl substituents at the N'-position	1.95	1	0	nitroso compound	alkylating agent
5-methyltetrahydrohomofolic acid 5-methyltetrahydrohomofolic acid: RN given refers to parent cpd	2.04	1	0
ninopterin ninopterin: structure	2.04	1	0
levomefolate calcium levomefolate calcium: an ingredient in Contraceptives, Oral, Combined. levomefolate calcium : An organic calcium salt of (6S)-5-methyltetrahydrofolic acid.	3.23	1	0	organic calcium salt	antidepressant
lipoteichoic acid lipoteichoic acid: lipopolysaccharides with an acyl group anchored to the cell membrane of gram-positive bacteria; functions as an adhesion molecule to facilitate the binding of bacteria to cells, colonization, and invasion; interacts with CD14 to induce NF-κB activation and inflammatory cytokine production; can function as surface antigen; inhibits remineraliztion of artificial lesions and surface-softened enamels;. lipoteichoic acid : A teichoic acid which is covalently bound to a lipid.	2.93	4	0
eye [no description available]	2.35	2	0
concanavalin a Concanavalin A: A MANNOSE/GLUCOSE binding lectin isolated from the jack bean (Canavalia ensiformis). It is a potent mitogen used to stimulate cell proliferation in lymphocytes, primarily T-lymphocyte, cultures.	1.98	1	0

oxacillin

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Research Demand Index: 79.66

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Clinical Response (Cure, Failure, or Indeterminate) as Determined by the Investigator Based the Presence or Absence of Clinical Signs and Symptoms Associated With Bacteremia, Metastatic Complications, or Positive Culture at the Test of Cure Evaluation

Any Creatine Phosphokinase (CPK) Elevation > 500 Units Per Liter (U/L)

Pharmacokinetic Parameter: Area Under the Concentration-time Curve During a Dosing Interval at Steady State (AUCss)

Pharmacokinetic Parameter: Maximum Plasma Concentration (Cmax)

Microbiological Response

Overall Clinical Outcome

Safety - Notable Laboratory Abnormalities

Pharmacokinetics (PK): Area Under the Plasma Concentration-Time Curve for Daptomycin From 0 to the Last Sampling Time Point (AUC[0-t])

Percentage of Participants With an Overall Therapeutic Response at Test of Cure Visit

Percentage of Participants With Treatment-Emergent Adverse Events (TEAEs)

Number of Participants With Treatment-emergent Creatine Phosphokinase (CPK) Elevations Through End of Therapy/Early Termination (EOT/ET)

Overall Therapeutic Outcome at Test of Cure (TOC)/Safety Visit

Duration of Treatment (Intravenous)

Duration of Treatment (Intravenous and Oral)

Number of Participants With Microbiological Response at Test-of-Cure (TOC) Visit

Number of Patients With Adverse Events, Serious Adverse Events and Death

Number of Patients With Clinical Success at the Test-Of-Cure (TOC) Visit

Cure Rate

Number of Participants That Changed From Vancomycin to Another Study Antibiotic Due to an Adverse Event

Number of Participants With Adverse Events Leading to Study Drug Withdrawal

Number of Participants With Serious Adverse Events

Antibiotic Days by Treatment Group

Investigator Clinical Response (Success or Failure) at EOT in the Microbiological All-treated (mAT) Population

Number of Participants With a Clinical Outcome of Cure at Test of Cure (TOC)

Number of Participants With an Investigator Clinical Outcome of Cure at TOC in the Microbiological All-treated (mAT) Population

Number of Participants With the Development of a New Metastatic Foci of S. Aureus Infection at Test of Cure (TOC) in the Microbiological All-treated (mAT) Populations

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