| Substance | Description | Relationhip Strength | Studies | Trials | Classes | Roles |
|---|
| glycine | [no description available] | medium | 6 | 0 | alpha-amino acid;
amino acid zwitterion;
proteinogenic amino acid;
serine family amino acid | EC 2.1.2.1 (glycine hydroxymethyltransferase) inhibitor;
fundamental metabolite;
hepatoprotective agent;
micronutrient;
neurotransmitter;
NMDA receptor agonist;
nutraceutical |
| transforming growth factor beta | [no description available] | medium | 1 | 0 | | |
| chenodeoxycholic acid | [no description available] | medium | 33 | 0 | bile acid;
C24-steroid;
dihydroxy-5beta-cholanic acid | human metabolite;
mouse metabolite |
| ursodeoxycholic acid | [no description available] | medium | 18 | 0 | bile acid;
C24-steroid;
dihydroxy-5beta-cholanic acid | human metabolite;
mouse metabolite |
| ursodeoxycholic acid | [no description available] | medium | 18 | 1 | bile acid;
C24-steroid;
dihydroxy-5beta-cholanic acid | human metabolite;
mouse metabolite |
| gw 4064 | [no description available] | medium | 2 | 0 | stilbenoid | |
| glucagon-like peptide 1 | [no description available] | medium | 1 | 0 | | |
| isoxazoles | [no description available] | medium | 2 | 0 | isoxazoles;
mancude organic heteromonocyclic parent;
monocyclic heteroarene | |
| hyodeoxycholic acid | [no description available] | medium | 20 | 0 | 5beta-cholanic acids;
6alpha,20xi-murideoxycholic acid;
bile acid;
C24-steroid | human metabolite;
mouse metabolite |
| deoxycholic acid | [no description available] | medium | 33 | 0 | bile acid;
C24-steroid;
dihydroxy-5beta-cholanic acid | human blood serum metabolite |
| taurocholic acid | [no description available] | medium | 7 | 0 | amino sulfonic acid;
bile acid taurine conjugate | human metabolite |
| methanol | [no description available] | medium | 2 | 0 | alkyl alcohol;
one-carbon compound;
primary alcohol;
volatile organic compound | amphiprotic solvent;
Escherichia coli metabolite;
fuel;
human metabolite;
mouse metabolite;
Mycoplasma genitalium metabolite |
| formic acid | [no description available] | medium | 1 | 0 | monocarboxylic acid | antibacterial agent;
astringent;
metabolite;
protic solvent;
solvent |
| lithocholic acid | [no description available] | medium | 9 | 0 | bile acid;
C24-steroid;
monohydroxy-5beta-cholanic acid | geroprotector;
human metabolite;
mouse metabolite |
| cholic acid | [no description available] | medium | 30 | 0 | 12alpha-hydroxy steroid;
3alpha-hydroxy steroid;
7alpha-hydroxy steroid;
bile acid;
C24-steroid;
trihydroxy-5beta-cholanic acid | human metabolite;
mouse metabolite |
| ursocholic acid | [no description available] | medium | 7 | 0 | 12alpha-hydroxy steroid;
3alpha-hydroxy steroid;
7beta-hydroxy steroid;
bile acid;
C24-steroid;
trihydroxy-5beta-cholanic acid | EC 1.1.1.159 (7alpha-hydroxysteroid dehydrogenase) inhibitor;
human urinary metabolite |
| ursocholic acid | [no description available] | medium | 7 | 1 | 12alpha-hydroxy steroid;
3alpha-hydroxy steroid;
7beta-hydroxy steroid;
bile acid;
C24-steroid;
trihydroxy-5beta-cholanic acid | EC 1.1.1.159 (7alpha-hydroxysteroid dehydrogenase) inhibitor;
human urinary metabolite |
| ampicillin | [no description available] | medium | 3 | 0 | beta-lactam antibiotic;
penicillin allergen;
penicillin | antibacterial drug |
| taurine | [no description available] | medium | 3 | 0 | amino sulfonic acid;
zwitterion | antioxidant;
Escherichia coli metabolite;
glycine receptor agonist;
human metabolite;
mouse metabolite;
nutrient;
radical scavenger;
Saccharomyces cerevisiae metabolite |
| rifampin | [no description available] | medium | 2 | 0 | cyclic ketal;
hydrazone;
N-iminopiperazine;
N-methylpiperazine;
rifamycins;
semisynthetic derivative;
zwitterion | angiogenesis inhibitor;
antiamoebic agent;
antineoplastic agent;
antitubercular agent;
DNA synthesis inhibitor;
EC 2.7.7.6 (RNA polymerase) inhibitor;
Escherichia coli metabolite;
geroprotector;
leprostatic drug;
neuroprotective agent;
pregnane X receptor agonist;
protein synthesis inhibitor |
| streptomycin | [no description available] | medium | 1 | 0 | antibiotic antifungal drug;
antibiotic fungicide;
streptomycins | antibacterial drug;
antifungal agrochemical;
antimicrobial agent;
antimicrobial drug;
bacterial metabolite;
protein synthesis inhibitor |
| framycetin | [no description available] | medium | 1 | 0 | aminoglycoside | allergen;
antibacterial drug;
Escherichia coli metabolite |
| oxytetracycline, anhydrous | [no description available] | medium | 1 | 0 | | |
| cholanic acid | [no description available] | medium | 1 | 0 | cholanic acids | |
| bilirubin | [no description available] | medium | 2 | 0 | biladienes;
dicarboxylic acid | antioxidant;
human metabolite;
mouse metabolite |
| theophylline | [no description available] | medium | 1 | 0 | dimethylxanthine | adenosine receptor antagonist;
anti-asthmatic drug;
anti-inflammatory agent;
bronchodilator agent;
drug metabolite;
EC 3.1.4.* (phosphoric diester hydrolase) inhibitor;
fungal metabolite;
human blood serum metabolite;
immunomodulator;
muscle relaxant;
vasodilator agent |
| glucagon | [no description available] | medium | 1 | 0 | peptide hormone | |
| gamma-sitosterol | [no description available] | medium | 1 | 0 | 3beta-hydroxy-Delta(5)-steroid;
3beta-sterol;
phytosterols | marine metabolite;
plant metabolite |
| cytellin | [no description available] | medium | 1 | 0 | | |
| norcholate | [no description available] | medium | 1 | 0 | bile acid | |
| allocholic acid | [no description available] | medium | 2 | 0 | 12alpha-hydroxy steroid;
3alpha-hydroxy steroid;
7alpha-hydroxy steroid;
allo-bile acid;
C24-steroid | human metabolite;
marine metabolite;
rat metabolite |
| 1,3,7,12-tetrahydroxycholanoic acid | [no description available] | medium | 1 | 0 | | |
| 2-acetylaminofluorene | [no description available] | medium | 1 | 0 | 2-acetamidofluorenes | antimitotic;
carcinogenic agent;
epitope;
mutagen |
| diethylnitrosamine | [no description available] | medium | 1 | 0 | nitrosamine | carcinogenic agent;
hepatotoxic agent;
mutagen |
| sodium borohydride | [no description available] | medium | 1 | 0 | inorganic sodium salt;
metal tetrahydridoborate | |
| glycocholic acid | [no description available] | medium | 2 | 0 | bile acid glycine conjugate | human metabolite |
| methylnitrosourea | [no description available] | medium | 1 | 0 | N-nitrosoureas | alkylating agent;
carcinogenic agent;
mutagen;
teratogenic agent |
| sulfolithocholic acid | [no description available] | medium | 1 | 0 | steroid sulfate | |
| 1,2-dimethylhydrazine | [no description available] | medium | 1 | 0 | hydrazines | alkylating agent;
carcinogenic agent |
| dimethylhydrazines | [no description available] | medium | 1 | 0 | | |
| lithium | [no description available] | medium | 1 | 0 | alkali metal atom | |
| ammonium hydroxide | [no description available] | medium | 1 | 0 | azane;
gas molecular entity;
mononuclear parent hydride | EC 3.5.1.4 (amidase) inhibitor;
metabolite;
mouse metabolite;
neurotoxin;
NMR chemical shift reference compound;
nucleophilic reagent;
refrigerant |
| phenyl acetate | [no description available] | medium | 1 | 0 | benzenes;
phenyl acetates | |
| pravastatin | [no description available] | medium | 1 | 0 | 3-hydroxy carboxylic acid;
carbobicyclic compound;
carboxylic ester;
hydroxy monocarboxylic acid;
secondary alcohol;
statin (semi-synthetic) | anticholesteremic drug;
environmental contaminant;
metabolite;
xenobiotic |
| taurochenodeoxycholic acid | [no description available] | medium | 3 | 0 | bile acid taurine conjugate | human metabolite;
mouse metabolite |
| ursodoxicoltaurine | [no description available] | medium | 3 | 0 | bile acid taurine conjugate | anti-inflammatory agent;
apoptosis inhibitor;
bone density conservation agent;
cardioprotective agent;
human metabolite;
neuroprotective agent |
| clofibrate | [no description available] | medium | 1 | 0 | aromatic ether;
ethyl ester;
monochlorobenzenes | anticholesteremic drug;
antilipemic drug;
geroprotector;
PPARalpha agonist |
| cholestyramine resin | [no description available] | medium | 1 | 0 | | |
| moxalactam | [no description available] | medium | 1 | 0 | cephalosporin;
oxacephem | antibacterial drug |
| cefotaxime | [no description available] | medium | 1 | 0 | 1,3-thiazoles;
cephalosporin;
oxime O-ether | antibacterial drug;
drug allergen |
| 6 beta-hydroxycortisol | [no description available] | medium | 1 | 0 | 11beta-hydroxy steroid;
17alpha-hydroxy steroid;
20-oxo steroid;
21-hydroxy steroid;
3-oxo-Delta(4) steroid;
6beta-hydroxy steroid;
C21-steroid;
primary alpha-hydroxy ketone;
tertiary alpha-hydroxy ketone | human metabolite;
mammalian metabolite;
probe |
| triiodothyronine | [no description available] | medium | 1 | 0 | 2-halophenol;
amino acid zwitterion;
iodophenol;
iodothyronine | human metabolite;
mouse metabolite;
thyroid hormone |
| azoxymethane | [no description available] | medium | 1 | 0 | | |
| isoursodeoxycholic acid | [no description available] | medium | 1 | 0 | dihydroxy-5beta-cholanic acid | human metabolite |
| 1,2-bis(2-aminophenoxy)ethane-n,n,n',n'-tetraacetic acid | [no description available] | medium | 1 | 0 | polyamino carboxylic acid;
tetracarboxylic acid | chelator |
| bucladesine | [no description available] | medium | 2 | 0 | 3',5'-cyclic purine nucleotide | |
| pyrroles | [no description available] | medium | 1 | 0 | pyrrole;
secondary amine | |
| 1-(5-isoquinolinesulfonyl)-2-methylpiperazine | [no description available] | medium | 1 | 0 | isoquinolines;
N-sulfonylpiperazine | EC 2.7.11.13 (protein kinase C) inhibitor |
| taurolithocholic acid | [no description available] | medium | 1 | 0 | bile acid taurine conjugate;
monocarboxylic acid amide | human metabolite |
| staurosporine | [no description available] | medium | 1 | 0 | ammonium ion derivative | |
| egtazic acid | [no description available] | medium | 1 | 0 | diether;
tertiary amino compound;
tetracarboxylic acid | chelator |
| kt 5720 | [no description available] | medium | 1 | 0 | carboxylic ester;
gamma-lactam;
hemiaminal;
indolocarbazole;
organic heterooctacyclic compound;
semisynthetic derivative;
tertiary alcohol | EC 2.7.11.11 (cAMP-dependent protein kinase) inhibitor |
| hydrogen carbonate | [no description available] | medium | 3 | 0 | carbon oxoanion | cofactor;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite |
| colchicine | [no description available] | medium | 1 | 0 | alkaloid;
colchicine | anti-inflammatory agent;
gout suppressant;
mutagen |
| tauromuricholate | [no description available] | medium | 1 | 0 | | |
| cellulose | [no description available] | medium | 1 | 0 | glycoside | |
| calcimycin | [no description available] | medium | 1 | 0 | benzoxazole | |
| verapamil | [no description available] | medium | 1 | 0 | aromatic ether;
nitrile;
polyether;
tertiary amino compound | |
| sucrose | [no description available] | medium | 1 | 0 | glycosyl glycoside | algal metabolite;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
osmolyte;
Saccharomyces cerevisiae metabolite;
sweetening agent |
| silicon | [no description available] | medium | 1 | 0 | carbon group element atom;
metalloid atom;
nonmetal atom | |
| tetrahydrocortisol | [no description available] | low | 0 | 0 | 11beta-hydroxy steroid;
17alpha-hydroxy steroid;
20-oxo steroid;
21-hydroxy steroid;
3alpha-hydroxy steroid;
glucocorticoid;
primary alpha-hydroxy ketone;
tertiary alpha-hydroxy ketone | |
| androsterone | [no description available] | low | 0 | 0 | 17-oxo steroid;
3alpha-hydroxy steroid;
androstanoid;
C19-steroid | androgen;
anticonvulsant;
human blood serum metabolite;
human metabolite;
human urinary metabolite;
mouse metabolite;
pheromone |
| etiocholanolone | [no description available] | low | 0 | 0 | 17-oxo steroid;
3alpha-hydroxy steroid;
androstanoid | human metabolite;
mouse metabolite |
| pregnanolone | [no description available] | low | 0 | 0 | 3-hydroxy-5beta-pregnan-20-one;
3alpha-hydroxy steroid | human metabolite;
intravenous anaesthetic;
sedative |
| 3 alpha,17 alpha-dihydroxy-5 beta-pregnan-20-one | [no description available] | low | 0 | 0 | 17alpha-hydroxy steroid;
20-oxo steroid;
3alpha-hydroxy steroid;
C21-steroid;
corticosteroid hormone | human urinary metabolite |
| brassinolide | [no description available] | low | 0 | 0 | 22-hydroxy steroid;
23-hydroxy steroid;
2alpha-hydroxy steroid;
3alpha-hydroxy steroid;
brassinosteroid | plant growth stimulator;
plant hormone |
| 3,7,12-trihydroxycoprostanic acid | [no description available] | low | 0 | 0 | 12alpha-hydroxy steroid;
3alpha-hydroxy steroid;
7alpha-hydroxy steroid;
cholestanoic acid;
hydroxy monocarboxylic acid | human metabolite |
| 3,7,12-trihydroxycholestan-26-oic acid | [no description available] | low | 0 | 0 | 12alpha-hydroxy steroid;
3alpha-hydroxy steroid;
7alpha-hydroxy steroid;
hydroxy monocarboxylic acid;
steroid acid | human metabolite |
| castasterone | [no description available] | low | 0 | 0 | 22-hydroxy steroid;
23-hydroxy steroid;
2alpha-hydroxy steroid;
3alpha-hydroxy steroid;
6-oxo steroid;
brassinosteroid | plant growth stimulator |
| 3,7,12-trihydroxycoprostane | [no description available] | low | 0 | 0 | 12alpha-hydroxy steroid;
3alpha-hydroxy steroid;
7alpha-hydroxy steroid | human metabolite;
mouse metabolite |
| scymnol | [no description available] | low | 0 | 0 | 12alpha-hydroxy steroid;
24-hydroxy steroid;
26-hydroxy steroid;
27-hydroxy steroid;
3alpha-hydroxy steroid;
7alpha-hydroxy steroid | |
| cholestane-3,7,12,26-tetrol | [no description available] | low | 0 | 0 | 12alpha-hydroxy steroid;
26-hydroxy steroid;
3alpha-hydroxy steroid;
7alpha-hydroxy steroid | human metabolite;
mouse metabolite |
| rocuronium | [no description available] | low | 0 | 0 | 3alpha-hydroxy steroid;
acetate ester;
androstane;
morpholines;
quaternary ammonium ion;
tertiary amino compound | drug allergen;
muscle relaxant;
neuromuscular agent |
| 7-ketolithocholic acid | [no description available] | low | 0 | 0 | 3alpha-hydroxy steroid;
bile acid;
monohydroxy-5beta-cholanic acid;
oxo-5beta-cholanic acid | human metabolite |
| obeticholic acid | [no description available] | low | 0 | 0 | 3alpha-hydroxy steroid;
7alpha-hydroxy steroid;
dihydroxy-5beta-cholanic acid | farnesoid X receptor agonist;
hepatoprotective agent |
| fusidic acid | [no description available] | low | 0 | 0 | 11alpha-hydroxy steroid;
3alpha-hydroxy steroid;
alpha,beta-unsaturated monocarboxylic acid;
steroid acid;
steroid antibiotic;
sterol ester | EC 2.7.1.33 (pantothenate kinase) inhibitor;
Escherichia coli metabolite;
protein synthesis inhibitor |
| 3,7,12,24-tetrahydroxycholestanoic acid | [no description available] | low | 0 | 0 | 12alpha-hydroxy steroid;
24-hydroxy steroid;
3alpha-hydroxy steroid;
7alpha-hydroxy steroid;
hydroxy monocarboxylic acid | bile acid metabolite |
| dihydroxycoprostane | [no description available] | low | 0 | 0 | 3alpha-hydroxy steroid;
7alpha-hydroxy steroid | human metabolite;
mouse metabolite |
| 3alpha,12alpha-dihydroxy-4alpha-methylergosta-8,24(28)-dien-7,11-dione-26-oic acid | [no description available] | low | 0 | 0 | 11-oxo steroid;
12alpha-hydroxy steroid;
3alpha-hydroxy steroid;
7-oxo steroid;
monocarboxylic acid;
secondary alpha-hydroxy ketone;
steroid acid | antineoplastic agent;
metabolite |
| 3alpha-hydroxy-4alpha-methylergosta-8,24(28)-dien-7,11-dione-26-oic acid | [no description available] | low | 0 | 0 | 11-oxo steroid;
3alpha-hydroxy steroid;
7-oxo steroid;
monocarboxylic acid;
steroid acid | antineoplastic agent;
cholinergic antagonist;
metabolite;
serotonergic antagonist |
| squalamine | [no description available] | low | 0 | 0 | bile acid | |
| 12-ketolithocholic acid | [no description available] | low | 0 | 0 | bile acid | |
| 3,7,12-trihydroxycholest-24-enoic acid | [no description available] | low | 0 | 0 | bile acid | |
| msi 1436 | [no description available] | low | 0 | 0 | bile acid | |
| methyl cholate | [no description available] | low | 0 | 0 | bile acid | |
| dehydroeburicoic acid | [no description available] | low | 0 | 0 | bile acid | |
| antcin k | [no description available] | low | 0 | 0 | bile acid | metabolite |