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Vasopressin V1b receptor
A vasopressin V1b receptor that is encoded in the genome of rat. [OMA:P48974, PRO:DNx]
Synonyms
V1bR;
AVPR V1b;
AVPR V3;
Antidiuretic hormone receptor 1b;
Vasopressin V3 receptor
Research
Bioassay Publications (9)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 1 (11.11) | 18.7374 |
| 1990's | 4 (44.44) | 18.2507 |
| 2000's | 2 (22.22) | 29.6817 |
| 2010's | 2 (22.22) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Compounds (7)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| mozavaptan | Rattus norvegicus (Norway rat) | IC50 | 5.0000 | 1 | 1 |
| conivaptan | Rattus norvegicus (Norway rat) | Ki | 10.0000 | 1 | 1 |
| oxytocin | Rattus norvegicus (Norway rat) | Ki | 0.0610 | 1 | 1 |
| arginine vasopressin | Rattus norvegicus (Norway rat) | Ki | 0.0003 | 1 | 1 |
| ssr 149415 | Rattus norvegicus (Norway rat) | Ki | 0.0010 | 2 | 2 |
Drugs with Activation Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| arginine vasopressin | Rattus norvegicus (Norway rat) | Kd | 0.0006 | 2 | 2 |
Drugs with Other Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| arginine vasopressin | Rattus norvegicus (Norway rat) | Kact | 0.0023 | 1 | 1 |
| l 701324 | Rattus norvegicus (Norway rat) | Kb | 0.0280 | 1 | 1 |
| mdl 104653 | Rattus norvegicus (Norway rat) | Kb | 0.8800 | 1 | 1 |
Design and synthesis of the first selective agonists for the rat vasopressin V(1b) receptor: based on modifications of deamino-[Cys1]arginine vasopressin at positions 4 and 8.Journal of medicinal chemistry, , Feb-22, Volume: 50, Issue:4, 2007
Synthesis of oxytocin antagonists containing conformationally constrained amino acids in position 2.Bioorganic & medicinal chemistry letters, , Mar-08, Volume: 9, Issue:5, 1999
Enhanced selectivity of oxytocin antagonists containing sarcosine in position 7.Journal of medicinal chemistry, , Jan-21, Volume: 37, Issue:2, 1994
Synthesis and SAR studies of novel 2-(4-oxo-2-aryl-quinazolin-3(4H)-yl)acetamide vasopressin V1b receptor antagonists.Bioorganic & medicinal chemistry letters, , Mar-15, Volume: 21, Issue:6, 2011
Tetrahydroquinoline sulfonamides as vasopressin 1b receptor antagonists.Bioorganic & medicinal chemistry letters, , Nov-01, Volume: 19, Issue:21, 2009