An ATP-binding cassette sub-family C member 2 that is encoded in the genome of rat. [OMA:Q63120, PRO:DNx]
ATP-binding cassette sub-family C member 2;
Canalicular multidrug resistance protein;
Multidrug resistance-associated protein 2;
7.6.2.2
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 14 (73.68) | 18.2507 |
| 2000's | 5 (26.32) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| ono 1078 | Rattus norvegicus (Norway rat) | Ki | 41.1000 | 1 | 1 |
| probenecid | Rattus norvegicus (Norway rat) | Ki | 44.6000 | 1 | 1 |
| sulfobromophthalein sodium | Rattus norvegicus (Norway rat) | Ki | 2.5250 | 2 | 2 |
| glycyrrhizic acid | Rattus norvegicus (Norway rat) | Ki | 1.3750 | 2 | 2 |
| pravastatin | Rattus norvegicus (Norway rat) | Ki | 172.0000 | 1 | 1 |
| baicalin | Rattus norvegicus (Norway rat) | Ki | 7.9500 | 1 | 1 |
| grepafloxacin | Rattus norvegicus (Norway rat) | Ki | 1,890.0000 | 1 | 1 |
| methotrexate | Rattus norvegicus (Norway rat) | Ki | 341.3333 | 3 | 3 |
| temocaprilat | Rattus norvegicus (Norway rat) | Ki | 343.0000 | 1 | 1 |
| bq 123 | Rattus norvegicus (Norway rat) | Ki | 84.1000 | 1 | 1 |
| E3040 glucuronide | Rattus norvegicus (Norway rat) | Ki | 3.8400 | 1 | 1 |
| fusidic acid | Rattus norvegicus (Norway rat) | Ki | 8.7000 | 3 | 3 |
| leukotriene d4 | Rattus norvegicus (Norway rat) | IC50 | 5.4800 | 1 | 1 |
| leukotriene e4 | Rattus norvegicus (Norway rat) | IC50 | 9.8300 | 1 | 1 |
| estradiol-17 beta-glucuronide | Rattus norvegicus (Norway rat) | IC50 | 13.3000 | 1 | 1 |
| l 660,711 | Rattus norvegicus (Norway rat) | IC50 | 2.6200 | 1 | 1 |
| cyclosporine | Rattus norvegicus (Norway rat) | Ki | 5.9800 | 2 | 2 |
| cefodizime | Rattus norvegicus (Norway rat) | Ki | 10.0000 | 1 | 1 |
| 5-methyltetrahydrofolate | Rattus norvegicus (Norway rat) | Ki | 121.0000 | 1 | 1 |
| 5,10-methylenetetrahydrofolic acid | Rattus norvegicus (Norway rat) | Ki | 269.0000 | 1 | 1 |
| leucovorin | Rattus norvegicus (Norway rat) | Ki | 132.0000 | 1 | 1 |
| 5,6,7,8-tetrahydrofolic acid | Rattus norvegicus (Norway rat) | Ki | 358.0000 | 1 | 1 |
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| sulfobromophthalein sodium | Rattus norvegicus (Norway rat) | Km | 31.0000 | 1 | 1 |
| pravastatin | Rattus norvegicus (Norway rat) | Km | 223.0000 | 1 | 1 |
| 4-nitrophenylglucuronide | Rattus norvegicus (Norway rat) | Km | 20.0000 | 1 | 1 |
| fluo-3 | Rattus norvegicus (Norway rat) | Km | 3.7000 | 1 | 1 |
| methotrexate | Rattus norvegicus (Norway rat) | Km | 296.0000 | 1 | 1 |
| temocaprilat | Rattus norvegicus (Norway rat) | Km | 92.5000 | 1 | 1 |
| bq 123 | Rattus norvegicus (Norway rat) | Km | 110.9000 | 2 | 2 |
| E3040 glucuronide | Rattus norvegicus (Norway rat) | Km | 5.7000 | 1 | 1 |
| leukotriene d4 | Rattus norvegicus (Norway rat) | Km | 1.5000 | 1 | 1 |
| estradiol-17 beta-glucuronide | Rattus norvegicus (Norway rat) | Km | 28.6033 | 3 | 3 |
| 5-methyltetrahydrofolate | Rattus norvegicus (Norway rat) | Km | 126.0000 | 1 | 1 |