Proteins > Voltage-dependent L-type calcium channel subunit alpha-1D
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Voltage-dependent L-type calcium channel subunit alpha-1D
A voltage-dependent L-type calcium channel subunit alpha-1D that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q01668]
Synonyms
Calcium channel, L type, alpha-1 polypeptide, isoform 2;
Voltage-gated calcium channel subunit alpha Cav1.3
Research
Bioassay Publications (11)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (18.18) | 18.2507 |
| 2000's | 1 (9.09) | 29.6817 |
| 2010's | 8 (72.73) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Compounds (69)
Drugs with Inhibition Measurements
Drugs with Activation Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| sumatriptan | Homo sapiens (human) | EC50 | 0.0120 | 1 | 1 |
| l 772405 | Homo sapiens (human) | EC50 | 0.0008 | 1 | 1 |
New Dual Small Molecules for Alzheimer's Disease Therapy Combining Histamine HJournal of medicinal chemistry, , 12-26, Volume: 62, Issue:24, 2019
Dimeric isoxazolyl-1,4-dihydropyridines have enhanced binding at the multi-drug resistance transporter.Bioorganic & medicinal chemistry, , 06-15, Volume: 25, Issue:12, 2017
New 5-unsubstituted dihydropyridines with improved CaV1.3 selectivity as potential neuroprotective agents against ischemic injury.Journal of medicinal chemistry, , May-22, Volume: 57, Issue:10, 2014
MICE models: superior to the HERG model in predicting Torsade de Pointes.Scientific reports, , Volume: 3, 2013
Simulation of multiple ion channel block provides improved early prediction of compounds' clinical torsadogenic risk.Cardiovascular research, , Jul-01, Volume: 91, Issue:1, 2011
Development, synthesis, and biological evaluation of (-)-trans-(2S,5S)-2-[3-[(2-oxopropyl)sulfonyl]-4-n-propoxy-5-(3- hydroxypropoxy)-phenyl]-5-(3,4,5-trimethoxyphenyl)tetrahydrofuran, a potent orally active platelet-activating factor (PAF) antagonist andJournal of medicinal chemistry, , Sep-18, Volume: 35, Issue:19, 1992
Development, synthesis, and biological evaluation of (-)-trans-(2S,5S)-2-[3-[(2-oxopropyl)sulfonyl]-4-n-propoxy-5-(3- hydroxypropoxy)-phenyl]-5-(3,4,5-trimethoxyphenyl)tetrahydrofuran, a potent orally active platelet-activating factor (PAF) antagonist andJournal of medicinal chemistry, , Sep-18, Volume: 35, Issue:19, 1992
Enables
This protein enables 8 target(s):
| Target | Category | Definition |
|---|
| voltage-gated calcium channel activity | molecular function | Enables the transmembrane transfer of a calcium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. [GOC:mtg_transport, GOC:tb, ISBN:0815340729] |
| calcium channel activity | molecular function | Enables the facilitated diffusion of a calcium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. [GOC:mtg_transport, GOC:pr, ISBN:0815340729] |
| protein binding | molecular function | Binding to a protein. [GOC:go_curators] |
| ankyrin binding | molecular function | Binding to ankyrin, a 200 kDa cytoskeletal protein that attaches other cytoskeletal proteins to integral membrane proteins. [GOC:mah, ISBN:0198506732] |
| metal ion binding | molecular function | Binding to a metal ion. [GOC:ai] |
| alpha-actinin binding | molecular function | Binding to alpha-actinin, one of a family of proteins that cross-link F-actin as antiparallel homodimers. Alpha-actinin has a molecular mass of 93-103 KDa; at the N-terminus there are two calponin homology domains, at the C-terminus there are two EF-hands. These two domains are connected by the rod domain. This domain is formed by triple-helical spectrin repeats. [PMID:10984498, PMID:11699871, PMID:15014165] |
| voltage-gated calcium channel activity involved in cardiac muscle cell action potential | molecular function | Enables the transmembrane transfer of a calcium ion by a voltage-gated channel across the plasma membrane of a cardiac muscle cell that contributes to the depolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] |
| voltage-gated calcium channel activity involved SA node cell action potential | molecular function | Enables the transmembrane transfer of a calcium ion by a voltage-gated channel across the plasma membrane of an SA node cardiac muscle cell that contributes to the depolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] |
Located In
This protein is located in 2 target(s):
| Target | Category | Definition |
|---|
| plasma membrane | cellular component | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363] |
| Z disc | cellular component | Platelike region of a muscle sarcomere to which the plus ends of actin filaments are attached. [GOC:mtg_muscle, ISBN:0815316194] |
Part Of
This protein is part of 2 target(s):
| Target | Category | Definition |
|---|
| voltage-gated calcium channel complex | cellular component | A protein complex that forms a transmembrane channel through which calcium ions may pass in response to changes in membrane potential. [GOC:mah] |
| L-type voltage-gated calcium channel complex | cellular component | A type of voltage-dependent calcium channel responsible for excitation-contraction coupling of skeletal, smooth, and cardiac muscle. 'L' stands for 'long-lasting' referring to the length of activation. [GOC:ame, PMID:12946355] |
Involved In
This protein is involved in 15 target(s):
| Target | Category | Definition |
|---|
| calcium ion transport | biological process | The directed movement of calcium (Ca) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai] |
| adenylate cyclase-modulating G protein-coupled receptor signaling pathway | biological process | A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation or inhibition of adenylyl cyclase activity and a subsequent change in the intracellular concentration of cyclic AMP (cAMP). [GOC:mah, GOC:signaling, ISBN:0815316194] |
| sensory perception of sound | biological process | The series of events required for an organism to receive an auditory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Sonic stimuli are detected in the form of vibrations and are processed to form a sound. [GOC:ai] |
| positive regulation of adenylate cyclase activity | biological process | Any process that activates or increases the frequency, rate or extent of adenylate cyclase activity. [GOC:go_curators] |
| positive regulation of calcium ion transport | biological process | Any process that activates or increases the frequency, rate or extent of the directed movement of calcium ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai] |
| regulation of atrial cardiac muscle cell membrane repolarization | biological process | Any process that modulates the establishment or extent of a membrane potential in the polarizing direction towards the resting potential in an atrial cardiomyocyte. [GOC:dph, GOC:tb] |
| calcium ion import | biological process | The directed movement of calcium ions into a cell or organelle. [GOC:mah] |
| calcium ion transmembrane transport | biological process | A process in which a calcium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore. [GOC:mah] |
| cardiac muscle cell action potential involved in contraction | biological process | An action potential that occurs in a cardiac muscle cell and is involved in its contraction. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] |
| membrane depolarization during cardiac muscle cell action potential | biological process | The process in which cardiac muscle cell membrane potential changes in the depolarizing direction from the negative resting potential towards the positive membrane potential that will be the peak of the action potential. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] |
| membrane depolarization during SA node cell action potential | biological process | The process in which SA node cardiac muscle cell membrane potential changes in the depolarizing direction from the negative resting potential towards the positive membrane potential that will be the peak of the action potential. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] |
| regulation of heart rate by cardiac conduction | biological process | A cardiac conduction process that modulates the frequency or rate of heart contraction. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] |
| regulation of potassium ion transmembrane transporter activity | biological process | Any process that modulates the frequency, rate or extent of potassium ion transmembrane transporter activity. [GOC:BHF, GOC:TermGenie] |
| regulation of potassium ion transmembrane transport | biological process | Any process that modulates the frequency, rate or extent of potassium ion transmembrane transport. [GOC:BHF, GOC:TermGenie] |
| calcium ion import across plasma membrane | biological process | The directed movement of calcium ions from outside of a cell, across the plasma membrane and into the cytosol. [GOC:dos] |