Transient receptor potential cation channel subfamily V member 1

A transient receptor potential cation channel TRPV1 that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q8NER1]

Synonyms

TrpV1;
Capsaicin receptor;
Osm-9-like TRP channel 1;
OTRPC1;
Vanilloid receptor 1

Research

Bioassay Publications (82)

Timeframe	Studies on this Protein(%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	1 (1.22)	18.2507
2000's	30 (36.59)	29.6817
2010's	40 (48.78)	24.3611
2020's	11 (13.41)	2.80

Compounds (68)

Drugs with Inhibition Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
cannabinol	Homo sapiens (human)	IC50	82.0000	1	1
citronellol	Homo sapiens (human)	IC50	100.0000	1	1
citronellyl acetate	Homo sapiens (human)	IC50	100.0000	1	1
cannabichromene	Homo sapiens (human)	IC50	50.0000	1	1
voacamine	Homo sapiens (human)	IC50	34.6667	3	3
(6ar-trans)-isomer of tetrahydrocannabivarin 9	Homo sapiens (human)	IC50	1.3000	1	1
1,1'-biphenyl-4-yl-boronic acid	Homo sapiens (human)	IC50	10.0000	1	1
geraniol	Homo sapiens (human)	IC50	100.0000	1	1
nerol	Homo sapiens (human)	IC50	100.0000	1	1
cannabidiol	Homo sapiens (human)	IC50	3.7000	1	1
sb 366791	Homo sapiens (human)	IC50	0.2300	2	2
(e)-3-(4-t-butylphenyl)-n-(2,3-dihydrobenzo(b)(1,4)dioxin-6-yl)acrylamide	Homo sapiens (human)	IC50	0.6392	5	8
hc 030031	Homo sapiens (human)	IC50	20.0000	1	1
zucapsaicin	Homo sapiens (human)	Ki	1.0800	1	1
capsaicin	Homo sapiens (human)	IC50	0.0080	2	2
capsaicin	Homo sapiens (human)	Ki	1.1865	4	4
geranyl acetate	Homo sapiens (human)	IC50	100.0000	1	1
capsazepine	Homo sapiens (human)	IC50	0.2587	15	17
capsazepine	Homo sapiens (human)	Ki	0.5093	3	3
phorbol 12-phenylacetate 13-acetate 20-homovanillate	Homo sapiens (human)	Ki	2.8334	3	3
6-iodonordihydrocapsaicin	Homo sapiens (human)	IC50	0.0100	1	1
pinosylvin	Homo sapiens (human)	IC50	10.0000	1	1
Pinosylvin methyl ether	Homo sapiens (human)	IC50	19.6750	4	4
pterostilbene	Homo sapiens (human)	IC50	10.0000	1	1
shogaol	Homo sapiens (human)	IC50	0.2900	1	1
4,4'-dihydroxystilbene	Homo sapiens (human)	IC50	10.0000	1	1
4-hydroxystilbene	Homo sapiens (human)	IC50	10.0000	1	1
olvanil	Homo sapiens (human)	Ki	1.5850	1	1
cannabigerol	Homo sapiens (human)	IC50	2.6000	2	2
3,5-dimethoxy-trans-stilbene	Homo sapiens (human)	IC50	10.0000	1	1
albaconol	Homo sapiens (human)	IC50	5.0000	1	1
3,4',5-trimethoxystilbene	Homo sapiens (human)	IC50	10.0000	1	1
iodoresiniferatoxin	Homo sapiens (human)	IC50	4.0000	1	1
iodoresiniferatoxin	Homo sapiens (human)	Ki	0.0088	4	4
1-isoquinolin-5-yl-3-(4-trifluoromethyl-benzyl)-urea	Homo sapiens (human)	IC50	0.0035	8	8
1-isoquinolin-5-yl-3-(4-trifluoromethyl-benzyl)-urea	Homo sapiens (human)	Ki	0.0234	3	3
sb 705498	Homo sapiens (human)	IC50	0.0546	2	2
n-(4-tert-butylphenyl)-4-(3-chloropyridin-2-yl)tetrahydropyrazine-1(2h)-carboxamide	Homo sapiens (human)	IC50	0.0119	18	18
n-(4-tert-butylphenyl)-4-(3-chloropyridin-2-yl)tetrahydropyrazine-1(2h)-carboxamide	Homo sapiens (human)	Ki	0.0058	3	3
arachidonoylserotonin	Homo sapiens (human)	IC50	4.6350	3	4
jyl 1421	Homo sapiens (human)	IC50	0.0540	1	1
jyl 1421	Homo sapiens (human)	Ki	0.0260	1	1
abt 102	Homo sapiens (human)	IC50	0.0031	5	5
abt 102	Homo sapiens (human)	Ki	0.0003	1	1
jnj 17203212	Homo sapiens (human)	IC50	0.0803	3	3
a 784168	Homo sapiens (human)	IC50	11.4080	3	3
a 784168	Homo sapiens (human)	Ki	0.0710	1	1
ly2183240	Homo sapiens (human)	IC50	100.0000	1	1
methylphenidate	Homo sapiens (human)	IC50	10.0000	1	1
cannabidivarin	Homo sapiens (human)	IC50	10.0000	1	1
amg 517	Homo sapiens (human)	IC50	0.0008	10	12
a 803467	Homo sapiens (human)	IC50	10.0000	1	1
mavatrep	Homo sapiens (human)	IC50	0.0115	3	3
mavatrep	Homo sapiens (human)	Ki	0.0065	1	1
am 6701	Homo sapiens (human)	IC50	31.3000	1	1
voacristine	Homo sapiens (human)	IC50	200.0000	1	1
abt 116	Homo sapiens (human)	IC50	0.0110	2	2

Drugs with Activation Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
2-aminoethoxydiphenyl borate	Homo sapiens (human)	EC50	129.0000	1	1
benzyl isothiocyanate	Homo sapiens (human)	EC50	223.0000	1	1
cannabinol	Homo sapiens (human)	EC50	6.2000	2	2
palmidrol	Homo sapiens (human)	EC50	10.0000	2	2
allyl isothiocyanate	Homo sapiens (human)	EC50	160.0000	1	1
phenethyl isothiocyanate	Homo sapiens (human)	EC50	180.0000	1	1
cannabichromene	Homo sapiens (human)	EC50	24.2000	1	1
voacamine	Homo sapiens (human)	Kd	19.9526	1	1
(6ar-trans)-isomer of tetrahydrocannabivarin 9	Homo sapiens (human)	EC50	0.8500	2	2
cp-55,940	Homo sapiens (human)	EC50	0.0100	1	1
4-hydroxybenzyl isothiocyanate	Homo sapiens (human)	EC50	170.0000	1	1
Tetrahydropiperine	Homo sapiens (human)	EC50	6.3096	1	1
piperine	Homo sapiens (human)	EC50	3.1623	1	1
ilepcimide	Homo sapiens (human)	EC50	19.9526	1	1
cannabidiol	Homo sapiens (human)	EC50	4.1000	1	1
sb 366791	Homo sapiens (human)	EC50	0.0200	1	1
(e)-3-(4-t-butylphenyl)-n-(2,3-dihydrobenzo(b)(1,4)dioxin-6-yl)acrylamide	Homo sapiens (human)	EC50	4.0000	1	1
zucapsaicin	Homo sapiens (human)	EC50	0.0282	1	1
capsaicin	Homo sapiens (human)	EC50	1.8463	17	18
capsazepine	Homo sapiens (human)	EC50	1.2719	2	2
shogaol	Homo sapiens (human)	EC50	0.3200	1	1
anandamide	Homo sapiens (human)	EC50	0.3072	5	5
arachidonyl dopamine	Homo sapiens (human)	EC50	0.7645	2	2
linoleoyl ethanolamide	Homo sapiens (human)	EC50	0.6300	1	1
n-oleoylethanolamine	Homo sapiens (human)	EC50	2.0575	4	4
olvanil	Homo sapiens (human)	EC50	0.0005	1	1
cannabigerol	Homo sapiens (human)	EC50	1.3000	2	2
Piperanine	Homo sapiens (human)	EC50	3.9811	1	1
piperlonguminine	Homo sapiens (human)	EC50	0.0063	1	1
catharanthine	Homo sapiens (human)	EC50	20.0000	1	1
arvanil	Homo sapiens (human)	EC50	0.0005	1	1
am 404	Homo sapiens (human)	EC50	0.0260	1	1
1-isoquinolin-5-yl-3-(4-trifluoromethyl-benzyl)-urea	Homo sapiens (human)	EC50	0.0085	3	4
sb 705498	Homo sapiens (human)	EC50	0.0320	1	1
jyl 1421	Homo sapiens (human)	EC50	0.0080	1	1
cannabidivarin	Homo sapiens (human)	EC50	3.6000	1	1
am 6701	Homo sapiens (human)	EC50	5.0000	1	1

Drugs with Other Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
2-aminoethoxydiphenyl borate	Homo sapiens (human)	Activity	10.0000	1	1
citronellol	Homo sapiens (human)	Activity	43.0000	1	1
allicin	Homo sapiens (human)	Activity	0.0990	1	1
voacamine	Homo sapiens (human)	Kb	18.0000	1	1
geraniol	Homo sapiens (human)	Activity	102.0000	1	1
piperine	Homo sapiens (human)	Activity	10.0000	1	1
capsaicin	Homo sapiens (human)	Activity	0.0100	1	1
anandamide	Homo sapiens (human)	Activity	1.0000	1	1
olvanil	Homo sapiens (human)	Activity	0.0100	1	1

Enables

This protein enables 15 target(s):

Target	Category	Definition
transmembrane signaling receptor activity	molecular function	Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity or state as part of signal transduction. [GOC:go_curators, Wikipedia:Transmembrane_receptor]
extracellular ligand-gated monoatomic ion channel activity	molecular function	Enables the transmembrane transfer of an ion by a channel that opens when a specific extracellular ligand has been bound by the channel complex or one of its constituent parts. [GOC:mtg_transport, ISBN:0815340729]
excitatory extracellular ligand-gated monoatomic ion channel activity	molecular function	Enables the transmembrane transfer of an ion by a channel that opens when a specific extracellular ligand has been bound by the channel complex or one of its constituent parts, where channel opening contributes to an increase in membrane potential. [GOC:mah, ISBN:0323037070]
voltage-gated calcium channel activity	molecular function	Enables the transmembrane transfer of a calcium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. [GOC:mtg_transport, GOC:tb, ISBN:0815340729]
calcium channel activity	molecular function	Enables the facilitated diffusion of a calcium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. [GOC:mtg_transport, GOC:pr, ISBN:0815340729]
protein binding	molecular function	Binding to a protein. [GOC:go_curators]
calmodulin binding	molecular function	Binding to calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states. [GOC:krc]
ATP binding	molecular function	Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. [ISBN:0198506732]
intracellularly gated calcium channel activity	molecular function	Enables the transmembrane transfer of a calcium ion by a channel that opens when a specific intracellular ligand has been bound by the channel complex or one of its constituent parts. [GOC:mah]
chloride channel regulator activity	molecular function	Binds to and modulates the activity of a chloride channel. [GOC:mah]
phosphatidylinositol binding	molecular function	Binding to an inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives. [GOC:bf, ISBN:0198506732, PMID:11395417]
identical protein binding	molecular function	Binding to an identical protein or proteins. [GOC:jl]
metal ion binding	molecular function	Binding to a metal ion. [GOC:ai]
phosphoprotein binding	molecular function	Binding to a phosphorylated protein. [GOC:ai]
temperature-gated ion channel activity	molecular function	Enables the transmembrane transfer of an ion by a channel that opens in response to a temperature stimulus (e.g. exposure to a temperature range different than the optimal temperature for that organism). [GOC:ha, GOC:pr, PMID:23027824]

Located In

This protein is located in 6 target(s):

Target	Category	Definition
plasma membrane	cellular component	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]
external side of plasma membrane	cellular component	The leaflet of the plasma membrane that faces away from the cytoplasm and any proteins embedded or anchored in it or attached to its surface. [GOC:dos, GOC:tb]
membrane	cellular component	A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. [GOC:dos, GOC:mah, ISBN:0815316194]
dendritic spine membrane	cellular component	The portion of the plasma membrane surrounding a dendritic spine. [GOC:mah]
neuronal cell body	cellular component	The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites. [GOC:go_curators]
postsynaptic membrane	cellular component	A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane. [ISBN:0198506732]

Active In

This protein is active in 1 target(s):

Target	Category	Definition
plasma membrane	cellular component	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]

Involved In

This protein is involved in 36 target(s):

Target	Category	Definition
negative regulation of transcription by RNA polymerase II	biological process	Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II. [GOC:go_curators, GOC:txnOH]
fever generation	biological process	The heat generation process that results in a rise in body temperature above the normal, often as a response to infection. [GOC:dph, GOC:jl]
microglial cell activation	biological process	The change in morphology and behavior of a microglial cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor. [GOC:mgi_curators, PMID:10626665, PMID:10695728, PMID:12580336, PMID:9893949]
diet induced thermogenesis	biological process	The process that results in increased metabolic rate in tissues of an organism. It is triggered by the detection of dietary excess. This process is achieved via signaling in the sympathetic nervous system. [PMID:12161655]
peptide secretion	biological process	The controlled release of a peptide from a cell or a tissue. [GOC:add]
negative regulation of systemic arterial blood pressure	biological process	The process that reduces the force with which blood travels through the systemic arterial circulatory system. [GOC:mtg_cardio]
lipid metabolic process	biological process	The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. [GOC:ma]
cell surface receptor signaling pathway	biological process	The series of molecular signals initiated by an extracellular ligand binding to a receptor located on the cell surface. The pathway ends with regulation of a downstream cellular process, e.g. transcription. [GOC:signaling]
positive regulation of cytosolic calcium ion concentration	biological process	Any process that increases the concentration of calcium ions in the cytosol. [GOC:ai]
chemosensory behavior	biological process	Behavior that is dependent upon the sensation of chemicals. [GOC:go_curators]
negative regulation of heart rate	biological process	Any process that stops, prevents or reduces the frequency or rate of heart contraction. [GOC:dph, GOC:tb]
negative regulation of mitochondrial membrane potential	biological process	Any process that stops, prevents, or reduces the frequency, rate or extent of establishment or extent of a mitochondrial membrane potential, the electric potential existing across any mitochondrial membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane. [GOC:dph, GOC:tb]
glutamate secretion	biological process	The controlled release of glutamate by a cell. The glutamate is the most abundant excitatory neurotransmitter in the nervous system. [GOC:ef]
calcium-mediated signaling	biological process	Any intracellular signal transduction in which the signal is passed on within the cell via calcium ions. [GOC:signaling]
cellular response to heat	biological process	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism. [GOC:mah]
positive regulation of apoptotic process	biological process	Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process. [GOC:jl, GOC:mtg_apoptosis]
response to peptide hormone	biological process	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide hormone stimulus. A peptide hormone is any of a class of peptides that are secreted into the blood stream and have endocrine functions in living animals. [PMID:11027914, PMID:15134857, Wikipedia:Peptide_hormone]
positive regulation of nitric oxide biosynthetic process	biological process	Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of nitric oxide. [GOC:go_curators]
behavioral response to pain	biological process	Any process that results in a change in the behavior of an organism as a result of a pain stimulus. Pain stimuli cause activation of nociceptors, peripheral receptors for pain, include receptors which are sensitive to painful mechanical stimuli, extreme heat or cold, and chemical stimuli. [GOC:jid]
sensory perception of mechanical stimulus	biological process	The series of events required for an organism to receive a sensory mechanical stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. [GOC:ai]
detection of temperature stimulus involved in thermoception	biological process	The series of events in which a temperature stimulus is received and converted into a molecular signal as part of thermoception. [GOC:ai, GOC:dos]
detection of temperature stimulus involved in sensory perception of pain	biological process	The series of events involved in the perception of pain in which a temperature stimulus is received and converted into a molecular signal. [GOC:ai, GOC:dos]
detection of chemical stimulus involved in sensory perception of pain	biological process	The series of events involved in the perception of pain in which a chemical stimulus is received and converted into a molecular signal. [GOC:ai]
protein homotetramerization	biological process	The formation of a protein homotetramer, a macromolecular structure consisting of four noncovalently associated identical subunits. [GOC:go_curators]
excitatory postsynaptic potential	biological process	A process that leads to a temporary increase in postsynaptic potential due to the flow of positively charged ions into the postsynaptic cell. The flow of ions that causes an EPSP is an excitatory postsynaptic current (EPSC) and makes it easier for the neuron to fire an action potential. [GOC:dph, GOC:ef]
smooth muscle contraction involved in micturition	biological process	The process leading to shortening and/or development of tension in the urinary bladder smooth muscle tissue involved in the expulsion urine from the body. [GOC:dph, PMID:15827347]
calcium ion transmembrane transport	biological process	A process in which a calcium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore. [GOC:mah]
cellular response to alkaloid	biological process	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an alkaloid stimulus. Alkaloids are a large group of nitrogenous substances found in naturally in plants, many of which have extracts that are pharmacologically active. [GOC:mah]
cellular response to ATP	biological process	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ATP (adenosine 5'-triphosphate) stimulus. [GOC:mah]
cellular response to tumor necrosis factor	biological process	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tumor necrosis factor stimulus. [GOC:mah]
cellular response to acidic pH	biological process	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pH stimulus with pH < 7. pH is a measure of the acidity or basicity of an aqueous solution. [GOC:go_curators, GOC:mah, Wikipedia:PH]
cellular response to temperature stimulus	biological process	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a temperature stimulus. [GOC:mah]
negative regulation of establishment of blood-brain barrier	biological process	Any process that decreases the rate, frequency or extent of the establishment of the blood-brain barrier, a selectively permeable structural and functional barrier that exists between the capillaries and the brain. [GOC:dph, GOC:tb]
calcium ion import across plasma membrane	biological process	The directed movement of calcium ions from outside of a cell, across the plasma membrane and into the cytosol. [GOC:dos]
response to capsazepine	biological process	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a capsazepine stimulus. [GOC:TermGenie]
cellular response to nerve growth factor stimulus	biological process	A process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nerve growth factor stimulus. [PMID:22399805, Wikipedia:Nerve_growth_factor]