N-acylethanolamine-hydrolyzing acid amidase

An N-acylethanolamine-hydrolyzing acid amidase that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q02083]

EC 3.5.1.60;
Acid ceramidase-like protein;
Acylsphingosine deacylase NAAA;
3.5.1.23;
N-acylsphingosine amidohydrolase-like;
ASAH-like protein

Research

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
cannabinol	Homo sapiens (human)	IC50	50.0000	1	1
diacerein	Homo sapiens (human)	IC50	0.7000	3	3
cannabichromene	Homo sapiens (human)	IC50	100.0000	1	1
(6ar-trans)-isomer of tetrahydrocannabivarin 9	Homo sapiens (human)	IC50	100.0000	1	1
delta(9)-tetrahydrocannabinolic acid	Homo sapiens (human)	IC50	50.0000	1	1
cannabidiolic acid	Homo sapiens (human)	IC50	23.0000	1	1
sc 58272	Homo sapiens (human)	IC50	14.1000	1	1
cannabidiol	Homo sapiens (human)	IC50	100.0000	1	1
cannabigerol	Homo sapiens (human)	IC50	100.0000	1	1
cannabigerolic acid	Homo sapiens (human)	IC50	50.0000	1	1
cannabidivarin	Homo sapiens (human)	IC50	72.3000	1	1

This protein enables 6 target(s):

Target	Category	Definition
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	molecular function	Catalysis of the hydrolysis of any carbon-nitrogen bond, C-N, with the exception of peptide bonds. [GOC:jl]
N-acylsphingosine amidohydrolase activity	molecular function	Catalysis of the reaction: N-acylsphingosine + H2O = a fatty acid + sphingosine. [EC:3.5.1.23]
fatty acid amide hydrolase activity	molecular function	Catalysis of the hydrolysis of a fatty acid amide to yield a fatty acid. [PMID:15952893]
N-(long-chain-acyl)ethanolamine deacylase activity	molecular function	Catalysis of the reaction: H2O + N-(long-chain-acyl)ethanolamine = ethanolamine + a fatty acid. [EC:3.5.1.60, MetaCyc:3.5.1.60-RXN]
ceramidase activity	molecular function	Catalysis of the reaction: H2O + a ceramide = a sphingoid base + a fatty acid. [EC:3.5.1.23, GOC:pz]
DNA-binding transcription factor binding	molecular function	Binding to a DNA-binding transcription factor, a protein that interacts with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. [GOC:txnOH-2018]

This protein is located in 5 target(s):

Target	Category	Definition
cytoplasm	cellular component	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684]
lysosome	cellular component	A small lytic vacuole that has cell cycle-independent morphology found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions. [GOC:mah, ISBN:0198506732]
membrane	cellular component	A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. [GOC:dos, GOC:mah, ISBN:0815316194]
lysosomal lumen	cellular component	The volume enclosed within the lysosomal membrane. [GOC:jl, PMID:15213228]
extracellular exosome	cellular component	A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894]

This protein is involved in 5 target(s):

Target	Category	Definition
fatty acid metabolic process	biological process	The chemical reactions and pathways involving fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis. [ISBN:0198547684]
sphingosine metabolic process	biological process	The chemical reactions and pathways involving sphingosine (sphing-4-enine), trans-D-erytho-2-amino-octadec-4-ene-1,3-diol, a long chain amino diol sphingoid base that occurs in most sphingolipids in animal tissues. [GOC:ma, ISBN:0198506732]
lipid catabolic process	biological process	The chemical reactions and pathways resulting in the breakdown of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. [GOC:go_curators]
N-acylethanolamine metabolic process	biological process	The chemical reactions and pathways involving N-acylethanolamines. An N-acylethanolamine is an ethanolamine substituted at nitrogen by an acyl group. [CHEBI:52640, GOC:elh, PMID:14634025, PMID:15878693]
N-acylphosphatidylethanolamine metabolic process	biological process	The chemical reactions and pathways involving N-acylphosphatidylethanolamines. An N-acylphosphatidylethanolamine is a phosphatidylethanolamine substituted at nitrogen by an acyl group. [GOC:elh, GOC:mah, PMID:14634025, PMID:15878693]