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50S ribosomal protein L1
A large ribosomal subunit protein uL1 that is encoded in the genome of Escherichia coli K-12. [PRO:DNx, UniProtKB:P0A7L0]
Synonyms
Large ribosomal subunit protein uL1
Research
Bioassay Publications (18)
Timeframe | Studies on this Protein(%) | All Drugs % |
pre-1990 | 2 (11.11) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 4 (22.22) | 29.6817 |
2010's | 8 (44.44) | 24.3611 |
2020's | 4 (22.22) | 2.80 |
Compounds (21)
Drugs with Inhibition Measurements
Drugs with Activation Measurements
Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
erythromycin | Escherichia coli K-12 | Kd | 0.5388 | 4 | 4 |
tiamulin | Escherichia coli K-12 | Kd | 0.0363 | 1 | 1 |
hmr 3647 | Escherichia coli K-12 | Kd | 0.0064 | 1 | 1 |
albocycline | Escherichia coli K-12 | Kd | 0.0024 | 1 | 1 |
evernimicin | Escherichia coli K-12 | Kd | 0.0840 | 1 | 1 |
cem 101 | Escherichia coli K-12 | Kd | 0.0006 | 1 | 1 |
Drugs with Other Measurements
Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
puromycin | Escherichia coli K-12 | Km | 234.0000 | 1 | 1 |
Distinct mode of interaction of a novel ketolide antibiotic that displays enhanced antimicrobial activity.Antimicrobial agents and chemotherapy, , Volume: 53, Issue:4, 2009
Activity of the novel macrolide BAL19403 against ribosomes from erythromycin-resistant Propionibacterium acnes.Antimicrobial agents and chemotherapy, , Volume: 51, Issue:12, 2007
Structure-activity relationships among the O-acyl derivatives of leucomycin. Correlation of minimal inhibitory concentrations with binding to Escherichia coli ribosomes.Journal of medicinal chemistry, , Volume: 20, Issue:5, 1977
Rigid spiroethers targeting the decoding center of the bacterial ribosome.Bioorganic & medicinal chemistry, , Feb-15, Volume: 22, Issue:4, 2014
Second generation analogs of rigid 6,7-spiro scaffolds targeting the bacterial ribosome.Bioorganic & medicinal chemistry letters, , Dec-15, Volume: 20, Issue:24, 2010
Influence of ring size in conformationally restricted ring I analogs of paromomycin on antiribosomal and antibacterial activity.RSC medicinal chemistry, , Sep-23, Volume: 12, Issue:9, 2021
Synthesis, ribosomal selectivity, and antibacterial activity of netilmicin 4'-derivatives.MedChemComm, , Jun-01, Volume: 10, Issue:6, 2019