Page last updated: 2024-08-07 23:31:52
Galanin receptor type 1
A galanin receptor type 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P47211]
Synonyms
GAL1-R;
GALR-1
Research
Bioassay Publications (2)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (50.00) | 29.6817 |
| 2010's | 1 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Compounds (5)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| m 35 | Homo sapiens (human) | Ki | 0.0000 | 1 | 1 |
| galantide | Homo sapiens (human) | Ki | 0.0000 | 1 | 1 |
| m40 | Homo sapiens (human) | Ki | 0.0001 | 1 | 1 |
| galmic | Homo sapiens (human) | Ki | 34.2000 | 1 | 1 |
Drugs with Activation Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| m 35 | Homo sapiens (human) | Kd | 0.0001 | 1 | 1 |
| galantide | Homo sapiens (human) | Kd | 0.0003 | 1 | 1 |
| galanin (1-16) | Homo sapiens (human) | Kd | 0.0032 | 1 | 1 |
Engineering galanin analogues that discriminate between GalR1 and GalR2 receptor subtypes and exhibit anticonvulsant activity following systemic delivery.Journal of medicinal chemistry, , Feb-25, Volume: 53, Issue:4, 2010
Design, synthesis, and characterization of high-affinity, systemically-active galanin analogues with potent anticonvulsant activities.Journal of medicinal chemistry, , Dec-25, Volume: 51, Issue:24, 2008
Engineering galanin analogues that discriminate between GalR1 and GalR2 receptor subtypes and exhibit anticonvulsant activity following systemic delivery.Journal of medicinal chemistry, , Feb-25, Volume: 53, Issue:4, 2010
Design, synthesis, and characterization of high-affinity, systemically-active galanin analogues with potent anticonvulsant activities.Journal of medicinal chemistry, , Dec-25, Volume: 51, Issue:24, 2008
Enables
This protein enables 5 target(s):
| Target | Category | Definition |
|---|
| galanin receptor activity | molecular function | Combining with galanin to initiate a change in cell activity. [GOC:ai] |
| protein binding | molecular function | Binding to a protein. [GOC:go_curators] |
| peptide hormone binding | molecular function | Binding to a peptide with hormonal activity in animals. [GOC:jl, ISBN:0198506732] |
| neuropeptide binding | molecular function | Interacting selectively and non-covalently and stoichiometrically with neuropeptides, peptides with direct synaptic effects (peptide neurotransmitters) or indirect modulatory effects on the nervous system (peptide neuromodulators). [http://www.wormbook.org/chapters/www_neuropeptides/neuropeptides.html] |
| G protein-coupled peptide receptor activity | molecular function | Combining with a peptide and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. [GOC:dph, GOC:tb] |
Located In
This protein is located in 2 target(s):
| Target | Category | Definition |
|---|
| plasma membrane | cellular component | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363] |
| membrane | cellular component | A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. [GOC:dos, GOC:mah, ISBN:0815316194] |
Active In
This protein is active in 1 target(s):
| Target | Category | Definition |
|---|
| plasma membrane | cellular component | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363] |
Involved In
This protein is involved in 6 target(s):
| Target | Category | Definition |
|---|
| adenylate cyclase-activating G protein-coupled receptor signaling pathway | biological process | A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation of adenylyl cyclase activity which results in an increase in the intracellular concentration of cyclic AMP (cAMP). This pathway is negatively regulated by phosphodiesterase, which cleaves cAMP and terminates the signaling. [GOC:dph, GOC:mah, GOC:signaling, GOC:tb, ISBN:0815316194] |
| negative regulation of adenylate cyclase activity | biological process | Any process that stops, prevents, or reduces the frequency, rate or extent of adenylate cyclase activity. [GOC:go_curators] |
| positive regulation of cytosolic calcium ion concentration | biological process | Any process that increases the concentration of calcium ions in the cytosol. [GOC:ai] |
| positive regulation of transcription by RNA polymerase II | biological process | Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter. [GOC:go_curators, GOC:txnOH] |
| positive regulation of cortisol secretion | biological process | Any process that activates or increases the frequency, rate or extent of the regulated release of cortisol from a cell. [GOC:ai] |
| neuropeptide signaling pathway | biological process | A G protein-coupled receptor signaling pathway initiated by a neuropeptide binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process. [GOC:mah, ISBN:0815316194] |