Somatostatin receptor type 2

A somatostatin receptor type 2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P30874]

Synonyms

SS-2-R;
SS2-R;
SS2R;
SRIF-1

Research

Bioassay Publications (25)

Timeframe	Studies on this Protein(%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	2 (8.00)	18.2507
2000's	16 (64.00)	29.6817
2010's	6 (24.00)	24.3611
2020's	1 (4.00)	2.80

Compounds (16)

Drugs with Inhibition Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
astemizole	Homo sapiens (human)	Ki	10.0000	1	1
camptothecin	Homo sapiens (human)	IC50	0.0022	1	1
edotreotide	Homo sapiens (human)	IC50	0.0140	1	1
octreotide	Homo sapiens (human)	Ki	0.0004	1	1
l803087	Homo sapiens (human)	IC50	7.0000	3	3
l803087	Homo sapiens (human)	Ki	4.7200	1	1
seglitide	Homo sapiens (human)	IC50	0.0016	1	1
seglitide	Homo sapiens (human)	Ki	0.0002	2	2
lanreotide	Homo sapiens (human)	Ki	0.0005	1	1
nnc 26-9100	Homo sapiens (human)	Ki	1.2877	3	3
l 363301	Homo sapiens (human)	Ki	0.0029	2	2
pasireotide	Homo sapiens (human)	Ki	0.0010	1	1
naluzotan	Homo sapiens (human)	Ki	2.0000	1	1
(1's, 2s)-4-amino-n-(1'-carbamoyl-2'-phenylethyl)-2-(4''-methyl-1''-naphthalenesulfonylamino)butanamide	Homo sapiens (human)	Ki	5.0000	1	1
l 054522	Homo sapiens (human)	Ki	0.0000	2	2
somatostatin	Homo sapiens (human)	IC50	0.0007	5	6
somatostatin	Homo sapiens (human)	Ki	0.0001	8	8

Drugs with Activation Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
octreotide	Homo sapiens (human)	EC50	0.0000	1	1
obelin	Homo sapiens (human)	Kd	36.3078	1	1
l 363301	Homo sapiens (human)	Kd	0.0008	1	1
somatostatin	Homo sapiens (human)	EC50	0.0001	1	1
prosomatostatin	Homo sapiens (human)	EC50	0.0023	1	1

Enables

This protein enables 4 target(s):

Target	Category	Definition
protein binding	molecular function	Binding to a protein. [GOC:go_curators]
PDZ domain binding	molecular function	Binding to a PDZ domain of a protein, a domain found in diverse signaling proteins. [GOC:go_curators, Pfam:PF00595]
somatostatin receptor activity	molecular function	Combining with somatostatin to initiate a change in cell activity. Somatostatin is a peptide hormone that regulates the endocrine system by signaling via G protein-coupled somatostatin receptors. Somatostatin has two active forms produced by proteolytic cleavage: a 14 amino acid peptide (SST-14) and a 28 amino acid peptide (SST-28). [GOC:ai, GOC:bf, Wikipedia:Somatostatin]
neuropeptide binding	molecular function	Interacting selectively and non-covalently and stoichiometrically with neuropeptides, peptides with direct synaptic effects (peptide neurotransmitters) or indirect modulatory effects on the nervous system (peptide neuromodulators). [http://www.wormbook.org/chapters/www_neuropeptides/neuropeptides.html]

Located In

This protein is located in 2 target(s):

Target	Category	Definition
cytosol	cellular component	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]
plasma membrane	cellular component	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]

Active In

This protein is active in 2 target(s):

Target	Category	Definition
neuron projection	cellular component	A prolongation or process extending from a nerve cell, e.g. an axon or dendrite. [GOC:jl, http://www.cogsci.princeton.edu/~wn/]
plasma membrane	cellular component	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]

Involved In

This protein is involved in 12 target(s):

Target	Category	Definition
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	biological process	A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation or inhibition of a nucleotide cyclase activity and a subsequent change in the concentration of a cyclic nucleotide. [GOC:mah, GOC:signaling, ISBN:0815316194]
adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	biological process	A G protein-coupled receptor signaling pathway in which the signal is transmitted via the inhibition of adenylyl cyclase activity and a subsequent decrease in the intracellular concentration of cyclic AMP (cAMP). [GOC:dph, GOC:mah, GOC:signaling, GOC:tb, ISBN:0815316194]
spermatogenesis	biological process	The developmental process by which male germ line stem cells self renew or give rise to successive cell types resulting in the development of a spermatozoa. [GOC:jid, ISBN:9780878933846, PMID:28073824, PMID:30990821]
negative regulation of cell population proliferation	biological process	Any process that stops, prevents or reduces the rate or extent of cell proliferation. [GOC:go_curators]
cerebellum development	biological process	The process whose specific outcome is the progression of the cerebellum over time, from its formation to the mature structure. The cerebellum is the portion of the brain in the back of the head between the cerebrum and the pons. In mice, the cerebellum controls balance for walking and standing, modulates the force and range of movement and is involved in the learning of motor skills. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
peristalsis	biological process	A wavelike sequence of involuntary muscular contraction and relaxation that passes along a tubelike structure, such as the intestine, impelling the contents onwards. [ISBN:0198506732]
forebrain development	biological process	The process whose specific outcome is the progression of the forebrain over time, from its formation to the mature structure. The forebrain is the anterior of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes especially the cerebral hemispheres, the thalamus, and the hypothalamus and especially in higher vertebrates is the main control center for sensory and associative information processing, visceral functions, and voluntary motor functions). [http://www2.merriam-webster.com/cgi-bin/mwmednlm?book=Medical&va=forebrain]
somatostatin signaling pathway	biological process	A G protein-coupled receptor signaling pathway initiated by somatostatin binding to a somatostatin receptor (SSTR), and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:bf, GOC:nhn, GOC:signaling, PMID:18006219, Wikipedia:Somatostatin]
response to starvation	biological process	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a starvation stimulus, deprivation of nourishment. [GOC:go_curators]
cellular response to glucocorticoid stimulus	biological process	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucocorticoid stimulus. Glucocorticoids are hormonal C21 corticosteroids synthesized from cholesterol with the ability to bind with the cortisol receptor and trigger similar effects. Glucocorticoids act primarily on carbohydrate and protein metabolism, and have anti-inflammatory effects. [GOC:mah]
cellular response to estradiol stimulus	biological process	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by estradiol, a C18 steroid hormone hydroxylated at C3 and C17 that acts as a potent estrogen. [GOC:mah]
neuropeptide signaling pathway	biological process	A G protein-coupled receptor signaling pathway initiated by a neuropeptide binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process. [GOC:mah, ISBN:0815316194]

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