Proteins > Lanosterol 14-alpha demethylase
Page last updated: 2024-08-07 12:58:10
Lanosterol 14-alpha demethylase
A protein that is a translation product of the ERG11 gene in Candida albicans SC5314. [PRO:DNx, UniProtKB:P10613]
Synonyms
EC 1.14.14.154;
CYPLI;
Cytochrome P450 51;
Cytochrome P450-14DM;
Cytochrome P450-LIA1;
Sterol 14-alpha demethylase
Research
Bioassay Publications (8)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (37.50) | 24.3611 |
| 2020's | 5 (62.50) | 2.80 |
Compounds (5)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| fluconazole | Candida albicans SC5314 | IC50 | 0.1296 | 5 | 5 |
Drugs with Activation Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| fluconazole | Candida albicans SC5314 | Kd | 0.0450 | 1 | 1 |
| voriconazole | Candida albicans SC5314 | Kd | 0.1650 | 1 | 1 |
| posaconazole | Candida albicans SC5314 | Kd | 0.0810 | 1 | 1 |
| vt-1161 | Candida albicans SC5314 | Kd | 0.0390 | 1 | 1 |
Drugs with Other Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| lanosterol | Candida albicans SC5314 | Km | 7.4000 | 1 | 1 |
[no title available]European journal of medicinal chemistry, , Jan-15, Volume: 228, 2022
Novel Aryl Alkamidazole Derivatives as Multifunctional Antifungal Inhibitors: Design, Synthesis, and Biological Evaluation.Journal of medicinal chemistry, , 11-10, Volume: 65, Issue:21, 2022
[no title available]European journal of medicinal chemistry, , Jan-05, Volume: 227, 2022
[no title available]Journal of medicinal chemistry, , 09-22, Volume: 65, Issue:18, 2022
Novel naphthylamide derivatives as dual-target antifungal inhibitors: Design, synthesis and biological evaluation.European journal of medicinal chemistry, , Jan-15, Volume: 210, 2021
Expression, purification, and characterization of Aspergillus fumigatus sterol 14-alpha demethylase (CYP51) isoenzymes A and B.Antimicrobial agents and chemotherapy, , Volume: 54, Issue:10, 2010
Sterol 14α-Demethylase Structure-Based Design of VNI (( R)- N-(1-(2,4-Dichlorophenyl)-2-(1 H-imidazol-1-yl)ethyl)-4-(5-phenyl-1,3,4-oxadiazol-2-yl)benzamide)) Derivatives To Target Fungal Infections: Synthesis, Biological Evaluation, and Crystallographic Journal of medicinal chemistry, , 07-12, Volume: 61, Issue:13, 2018
Sterol 14α-Demethylase Structure-Based Design of VNI (( R)- N-(1-(2,4-Dichlorophenyl)-2-(1 H-imidazol-1-yl)ethyl)-4-(5-phenyl-1,3,4-oxadiazol-2-yl)benzamide)) Derivatives To Target Fungal Infections: Synthesis, Biological Evaluation, and Crystallographic Journal of medicinal chemistry, , 07-12, Volume: 61, Issue:13, 2018