Page last updated: 2024-08-07 13:21:57
Thiopurine S-methyltransferase
A thiopurine S-methyltransferase that is encoded in the genome of human. [PRO:DNx, UniProtKB:P51580]
Synonyms
EC 2.1.1.67;
Thiopurine methyltransferase
Research
Bioassay Publications (2)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 1 (50.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Compounds (20)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| 4-hydroxybenzoic acid | Homo sapiens (human) | IC50 | 1,737.8000 | 1 | 1 |
| 3-chlorobenzoic acid | Homo sapiens (human) | IC50 | 194.9840 | 1 | 1 |
| 4-aminobenzoic acid | Homo sapiens (human) | IC50 | 2,884.0300 | 1 | 1 |
| 4-nitrobenzoic acid | Homo sapiens (human) | IC50 | 501.1870 | 1 | 1 |
| 4-chlorobenzoic acid | Homo sapiens (human) | IC50 | 186.2090 | 1 | 1 |
| veratric acid | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| 4-tert-butylbenzoic acid | Homo sapiens (human) | IC50 | 2,089.3000 | 1 | 1 |
| 3-toluic acid | Homo sapiens (human) | IC50 | 173.7800 | 1 | 1 |
| 3,5-dinitrobenzoic acid | Homo sapiens (human) | IC50 | 1,122.0200 | 1 | 1 |
| 4-toluic acid | Homo sapiens (human) | IC50 | 288.4030 | 1 | 1 |
| 4-anisic acid | Homo sapiens (human) | IC50 | 288.4030 | 1 | 1 |
| vanillic acid | Homo sapiens (human) | IC50 | 478.6300 | 1 | 1 |
| 3-nitrobenzoic acid | Homo sapiens (human) | IC50 | 371.5350 | 1 | 1 |
| carzenide | Homo sapiens (human) | IC50 | 616.5950 | 1 | 1 |
| 3,5-dimethylbenzoic acid | Homo sapiens (human) | IC50 | 33.1131 | 1 | 1 |
| 3-methoxybenzoic acid | Homo sapiens (human) | IC50 | 199.5260 | 1 | 1 |
| isovanillic acid | Homo sapiens (human) | IC50 | 1,288.2500 | 1 | 1 |
| 3,4-dimethoxy-5-hydroxybenzoic acid | Homo sapiens (human) | IC50 | 19.9526 | 1 | 1 |
| 3,5-dihydroxy-4-methoxybenzoic acid | Homo sapiens (human) | IC50 | 602.5600 | 1 | 1 |
Drugs with Activation Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| sinefungin | Homo sapiens (human) | Kd | 10.0000 | 1 | 1 |
Enables
This protein enables 3 target(s):
| Target | Category | Definition |
|---|---|---|
| protein binding | molecular function | Binding to a protein. [GOC:go_curators] |
| thiopurine S-methyltransferase activity | molecular function | Catalysis of the reaction: S-adenosyl-L-methionine + a thiopurine = S-adenosyl-L-homocysteine + a thiopurine S-methylether. [EC:2.1.1.67] |
| S-adenosyl-L-methionine binding | molecular function | Binding to S-adenosyl-L-methionine. [GO_REF:0000067, GOC:BHF, GOC:hal, GOC:TermGenie, PMID:22985361] |
Located In
This protein is located in 1 target(s):
| Target | Category | Definition |
|---|---|---|
| cytosol | cellular component | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl] |
Involved In
This protein is involved in 4 target(s):
| Target | Category | Definition |
|---|---|---|
| nucleobase-containing compound metabolic process | biological process | Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids. [GOC:ai] |
| xenobiotic metabolic process | biological process | The chemical reactions and pathways involving a xenobiotic compound, a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical. [GOC:cab2, GOC:krc] |
| methylation | biological process | The process in which a methyl group is covalently attached to a molecule. [GOC:mah] |
| xenobiotic catabolic process | biological process | The chemical reactions and pathways resulting in the breakdown of a xenobiotic compound, a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical. [GOC:jl, GOC:krc] |