Thiopurine S-methyltransferase

A thiopurine S-methyltransferase that is encoded in the genome of human. [PRO:DNx, UniProtKB:P51580]

EC 2.1.1.67;
Thiopurine methyltransferase

Research

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
4-hydroxybenzoic acid	Homo sapiens (human)	IC50	1,737.8000	1	1
3-chlorobenzoic acid	Homo sapiens (human)	IC50	194.9840	1	1
4-aminobenzoic acid	Homo sapiens (human)	IC50	2,884.0300	1	1
4-nitrobenzoic acid	Homo sapiens (human)	IC50	501.1870	1	1
4-chlorobenzoic acid	Homo sapiens (human)	IC50	186.2090	1	1
veratric acid	Homo sapiens (human)	IC50	100.0000	1	1
4-tert-butylbenzoic acid	Homo sapiens (human)	IC50	2,089.3000	1	1
3-toluic acid	Homo sapiens (human)	IC50	173.7800	1	1
3,5-dinitrobenzoic acid	Homo sapiens (human)	IC50	1,122.0200	1	1
4-toluic acid	Homo sapiens (human)	IC50	288.4030	1	1
4-anisic acid	Homo sapiens (human)	IC50	288.4030	1	1
vanillic acid	Homo sapiens (human)	IC50	478.6300	1	1
3-nitrobenzoic acid	Homo sapiens (human)	IC50	371.5350	1	1
carzenide	Homo sapiens (human)	IC50	616.5950	1	1
3,5-dimethylbenzoic acid	Homo sapiens (human)	IC50	33.1131	1	1
3-methoxybenzoic acid	Homo sapiens (human)	IC50	199.5260	1	1
isovanillic acid	Homo sapiens (human)	IC50	1,288.2500	1	1
3,4-dimethoxy-5-hydroxybenzoic acid	Homo sapiens (human)	IC50	19.9526	1	1
3,5-dihydroxy-4-methoxybenzoic acid	Homo sapiens (human)	IC50	602.5600	1	1

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
sinefungin	Homo sapiens (human)	Kd	10.0000	1	1

This protein enables 3 target(s):

Target	Category	Definition
protein binding	molecular function	Binding to a protein. [GOC:go_curators]
thiopurine S-methyltransferase activity	molecular function	Catalysis of the reaction: S-adenosyl-L-methionine + a thiopurine = S-adenosyl-L-homocysteine + a thiopurine S-methylether. [EC:2.1.1.67]
S-adenosyl-L-methionine binding	molecular function	Binding to S-adenosyl-L-methionine. [GO_REF:0000067, GOC:BHF, GOC:hal, GOC:TermGenie, PMID:22985361]

This protein is located in 1 target(s):

Target	Category	Definition
cytosol	cellular component	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]

This protein is involved in 4 target(s):

Target	Category	Definition
nucleobase-containing compound metabolic process	biological process	Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids. [GOC:ai]
xenobiotic metabolic process	biological process	The chemical reactions and pathways involving a xenobiotic compound, a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical. [GOC:cab2, GOC:krc]
methylation	biological process	The process in which a methyl group is covalently attached to a molecule. [GOC:mah]
xenobiotic catabolic process	biological process	The chemical reactions and pathways resulting in the breakdown of a xenobiotic compound, a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical. [GOC:jl, GOC:krc]