Tyrosinase

A tyrosinase that is encoded in the genome of human. [PRO:DNx, UniProtKB:P14679]

Synonyms

EC 1.14.18.1;
LB24-AB;
Monophenol monooxygenase;
SK29-AB;
Tumor rejection antigen AB

Research

Bioassay Publications (29)

Timeframe	Studies on this Protein(%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	12 (41.38)	29.6817
2010's	13 (44.83)	24.3611
2020's	4 (13.79)	2.80

Compounds (63)

Drugs with Inhibition Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
4-hydroxybenzoic acid	Homo sapiens (human)	IC50	9.3500	1	1
benzaldehyde	Homo sapiens (human)	IC50	820.0000	1	1
benzoic acid	Homo sapiens (human)	Ki	520.0000	1	1
cuminaldehyde	Homo sapiens (human)	IC50	50.0000	1	1
hydroquinone	Homo sapiens (human)	IC50	4,400.0000	2	2
hexylresorcinol	Homo sapiens (human)	IC50	47.2800	2	2
hexylresorcinol	Homo sapiens (human)	Ki	39.0000	1	1
beta-thujaplicin	Homo sapiens (human)	IC50	8.9800	2	2
kojic acid	Homo sapiens (human)	IC50	1,014.7415	19	20
kojic acid	Homo sapiens (human)	Ki	350.0000	1	1
resorcinol	Homo sapiens (human)	IC50	3,000.0000	1	1
levodopa	Homo sapiens (human)	IC50	8,400.0000	1	1
salicylaldehyde	Homo sapiens (human)	IC50	3,300.0000	1	1
xanthone	Homo sapiens (human)	IC50	8.8400	1	1
butylphen	Homo sapiens (human)	IC50	10.0000	1	1
gamma-thujaplicin	Homo sapiens (human)	IC50	1.1500	2	2
3-hydroxy-1-benzopyran-2-one	Homo sapiens (human)	Ki	3.4000	1	1
2-tert-butylhydroquinone	Homo sapiens (human)	IC50	54.2000	1	1
4-anisaldehyde	Homo sapiens (human)	IC50	320.0000	1	1
2-hydroxy-4-methoxybenzaldehyde	Homo sapiens (human)	IC50	30.0000	1	1
1-hydroxy-2(1h)-pyridinone	Homo sapiens (human)	IC50	725.0000	2	2
1-hydroxy-2(1h)-pyridinone	Homo sapiens (human)	Ki	128.0000	2	2
2-Methoxyxanthone	Homo sapiens (human)	IC50	8.4700	1	1
alpha-thujaplicin	Homo sapiens (human)	IC50	1,000.0000	1	1
arctiin	Homo sapiens (human)	IC50	50.0000	1	1
glabridin	Homo sapiens (human)	IC50	0.0900	1	1
moracin m	Homo sapiens (human)	IC50	8.0000	1	1
4-n-butylresorcinol	Homo sapiens (human)	IC50	21.0000	2	2
4-n-butylresorcinol	Homo sapiens (human)	Ki	9.1000	1	1
4-methoxyxanthone	Homo sapiens (human)	IC50	5.3300	1	1
mimosine	Homo sapiens (human)	IC50	3.6800	1	1
mimosine	Homo sapiens (human)	Ki	10.3000	1	1
arbutin	Homo sapiens (human)	IC50	6,489.4086	7	7
resveratrol	Homo sapiens (human)	IC50	985.1750	4	4
glabrene	Homo sapiens (human)	IC50	7.5000	1	1
glyasperin D	Homo sapiens (human)	IC50	0.1540	1	1
6-hydroxyindole	Homo sapiens (human)	IC50	22.0000	1	1
trans-4-coumaric acid	Homo sapiens (human)	IC50	2.3333	3	3
phenylthiourea	Homo sapiens (human)	IC50	1.8000	1	1
phenylthiourea	Homo sapiens (human)	Ki	1.7000	1	1
isoeugenol	Homo sapiens (human)	IC50	33.3300	1	1
curcumin	Homo sapiens (human)	IC50	5.0000	1	1
4-hydroxy-5-methyl-3(2h)-furanone	Homo sapiens (human)	IC50	50.0000	1	1
quercetin	Homo sapiens (human)	IC50	44.3800	1	1
luteolin	Homo sapiens (human)	IC50	60.0000	1	1
apigetrin	Homo sapiens (human)	IC50	50.0000	1	1
quercetin 3-o-glucopyranoside	Homo sapiens (human)	IC50	50.0000	1	1
kaempferol	Homo sapiens (human)	IC50	33.0550	2	2
hispidol	Homo sapiens (human)	IC50	38.4000	1	1
7-hydroxycoumarin	Homo sapiens (human)	IC50	420.0000	1	1
euxanthone	Homo sapiens (human)	IC50	4.5200	1	1
trans-2,3',4,5'-tetrahydroxystilbene	Homo sapiens (human)	IC50	6.7967	3	3
linarin	Homo sapiens (human)	IC50	50.0000	1	1
methyl-p-coumarate	Homo sapiens (human)	IC50	30.0000	2	2
tiliroside	Homo sapiens (human)	IC50	78.5300	1	1
tilianin	Homo sapiens (human)	IC50	50.0000	1	1
2,4,3',5'-tetramethoxystilbene	Homo sapiens (human)	IC50	100.0000	1	1
1-hydroxyxanthone	Homo sapiens (human)	IC50	8.8300	1	1
Norartocarpetin	Homo sapiens (human)	IC50	0.0230	1	1
3,4-dihydroxy-xanthone	Homo sapiens (human)	IC50	5.1200	1	1
hylin	Homo sapiens (human)	IC50	250.0000	1	1
apigenin-7-o-rutinoside	Homo sapiens (human)	IC50	50.0000	1	1
morachalcone a	Homo sapiens (human)	IC50	0.0800	1	1
2,4,2',4'-Tetrahydroxychalcone	Homo sapiens (human)	IC50	0.0700	1	1
4-(1-phenylethyl)resorcinol	Homo sapiens (human)	IC50	131.0000	1	1
4-(1-phenylethyl)resorcinol	Homo sapiens (human)	Ki	24.0000	1	1
3-hydroxyphloretin	Homo sapiens (human)	IC50	32.0000	1	1
subamolide a	Homo sapiens (human)	IC50	1.0000	1	1
feruloyldopamine	Homo sapiens (human)	IC50	50.0000	1	1
ascorbic acid	Homo sapiens (human)	IC50	32.5000	1	1

Drugs with Other Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
kojic acid	Homo sapiens (human)	Km	79.0000	4	4

Enables

This protein enables 5 target(s):

Target	Category	Definition
tyrosinase activity	molecular function	Catalysis of the reaction: L-tyrosine + O2 = L-DOPAquinone + H2O. This reaction can use both monophenols (such as tyrosine) and catechols (o-diphenols) as substrates. [PMID:4965136, RHEA:18117]
copper ion binding	molecular function	Binding to a copper (Cu) ion. [GOC:ai]
protein binding	molecular function	Binding to a protein. [GOC:go_curators]
identical protein binding	molecular function	Binding to an identical protein or proteins. [GOC:jl]
protein homodimerization activity	molecular function	Binding to an identical protein to form a homodimer. [GOC:jl]

Located In

This protein is located in 7 target(s):

Target	Category	Definition
cytoplasm	cellular component	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684]
lysosome	cellular component	A small lytic vacuole that has cell cycle-independent morphology found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions. [GOC:mah, ISBN:0198506732]
Golgi-associated vesicle	cellular component	Any vesicle associated with the Golgi complex and involved in mediating transport within the Golgi or between the Golgi and other parts of the cell. [GOC:mah]
melanosome membrane	cellular component	The lipid bilayer surrounding a melanosome. [GOC:mah]
melanosome	cellular component	A tissue-specific, membrane-bounded cytoplasmic organelle within which melanin pigments are synthesized and stored. Melanosomes are synthesized in melanocyte cells. [GOC:jl, PMID:11584301]
intracellular membrane-bounded organelle	cellular component	Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane. [GOC:go_curators]
perinuclear region of cytoplasm	cellular component	Cytoplasm situated near, or occurring around, the nucleus. [GOC:jid]

Involved In

This protein is involved in 11 target(s):

Target	Category	Definition
melanin biosynthetic process from tyrosine	biological process	The chemical reactions and pathways resulting in the formation of melanin from other compounds, including tyrosine. [GOC:go_curators]
eye pigment biosynthetic process	biological process	The chemical reactions and pathways resulting in the formation of eye pigments, any general or particular coloring matter in living organisms, found or utilized in the eye. [GOC:ai]
visual perception	biological process	The series of events required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual stimuli are detected in the form of photons and are processed to form an image. [GOC:ai]
cell population proliferation	biological process	The multiplication or reproduction of cells, resulting in the expansion of a cell population. [GOC:mah, GOC:mb]
response to UV	biological process	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ultraviolet radiation (UV light) stimulus. Ultraviolet radiation is electromagnetic radiation with a wavelength in the range of 10 to 380 nanometers. [GOC:hb]
response to blue light	biological process	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a blue light stimulus. Blue light is electromagnetic radiation with a wavelength of between 440 and 500nm. [GOC:ai, GOC:mtg_far_red]
response to vitamin D	biological process	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin D stimulus. [GOC:sl]
melanin biosynthetic process	biological process	The chemical reactions and pathways resulting in the formation of melanins, pigments largely of animal origin. High molecular weight polymers of indole quinone, they are irregular polymeric structures and are divided into three groups: allomelanins in the plant kingdom and eumelanins and phaeomelanins in the animal kingdom. [GOC:curators]
thymus development	biological process	The process whose specific outcome is the progression of the thymus over time, from its formation to the mature structure. The thymus is a symmetric bi-lobed organ involved primarily in the differentiation of immature to mature T cells, with unique vascular, nervous, epithelial, and lymphoid cell components. [GOC:add, ISBN:0781735149]
response to cAMP	biological process	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate) stimulus. [GOC:ai]
pigmentation	biological process	The accumulation of pigment in an organism, tissue or cell, either by increased deposition or by increased number of cells. [GOC:jl]