Page last updated: 2024-08-07 15:59:21
Tyrosinase
A tyrosinase that is encoded in the genome of human. [PRO:DNx, UniProtKB:P14679]
Synonyms
EC 1.14.18.1;
LB24-AB;
Monophenol monooxygenase;
SK29-AB;
Tumor rejection antigen AB
Research
Bioassay Publications (29)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 12 (41.38) | 29.6817 |
| 2010's | 13 (44.83) | 24.3611 |
| 2020's | 4 (13.79) | 2.80 |
Compounds (63)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| 4-hydroxybenzoic acid | Homo sapiens (human) | IC50 | 9.3500 | 1 | 1 |
| benzaldehyde | Homo sapiens (human) | IC50 | 820.0000 | 1 | 1 |
| benzoic acid | Homo sapiens (human) | Ki | 520.0000 | 1 | 1 |
| cuminaldehyde | Homo sapiens (human) | IC50 | 50.0000 | 1 | 1 |
| hydroquinone | Homo sapiens (human) | IC50 | 4,400.0000 | 2 | 2 |
| hexylresorcinol | Homo sapiens (human) | IC50 | 47.2800 | 2 | 2 |
| hexylresorcinol | Homo sapiens (human) | Ki | 39.0000 | 1 | 1 |
| beta-thujaplicin | Homo sapiens (human) | IC50 | 8.9800 | 2 | 2 |
| kojic acid | Homo sapiens (human) | IC50 | 1,014.7415 | 19 | 20 |
| kojic acid | Homo sapiens (human) | Ki | 350.0000 | 1 | 1 |
| resorcinol | Homo sapiens (human) | IC50 | 3,000.0000 | 1 | 1 |
| levodopa | Homo sapiens (human) | IC50 | 8,400.0000 | 1 | 1 |
| salicylaldehyde | Homo sapiens (human) | IC50 | 3,300.0000 | 1 | 1 |
| xanthone | Homo sapiens (human) | IC50 | 8.8400 | 1 | 1 |
| butylphen | Homo sapiens (human) | IC50 | 10.0000 | 1 | 1 |
| gamma-thujaplicin | Homo sapiens (human) | IC50 | 1.1500 | 2 | 2 |
| 3-hydroxy-1-benzopyran-2-one | Homo sapiens (human) | Ki | 3.4000 | 1 | 1 |
| 2-tert-butylhydroquinone | Homo sapiens (human) | IC50 | 54.2000 | 1 | 1 |
| 4-anisaldehyde | Homo sapiens (human) | IC50 | 320.0000 | 1 | 1 |
| 2-hydroxy-4-methoxybenzaldehyde | Homo sapiens (human) | IC50 | 30.0000 | 1 | 1 |
| 1-hydroxy-2(1h)-pyridinone | Homo sapiens (human) | IC50 | 725.0000 | 2 | 2 |
| 1-hydroxy-2(1h)-pyridinone | Homo sapiens (human) | Ki | 128.0000 | 2 | 2 |
| 2-Methoxyxanthone | Homo sapiens (human) | IC50 | 8.4700 | 1 | 1 |
| alpha-thujaplicin | Homo sapiens (human) | IC50 | 1,000.0000 | 1 | 1 |
| arctiin | Homo sapiens (human) | IC50 | 50.0000 | 1 | 1 |
| glabridin | Homo sapiens (human) | IC50 | 0.0900 | 1 | 1 |
| moracin m | Homo sapiens (human) | IC50 | 8.0000 | 1 | 1 |
| 4-n-butylresorcinol | Homo sapiens (human) | IC50 | 21.0000 | 2 | 2 |
| 4-n-butylresorcinol | Homo sapiens (human) | Ki | 9.1000 | 1 | 1 |
| 4-methoxyxanthone | Homo sapiens (human) | IC50 | 5.3300 | 1 | 1 |
| mimosine | Homo sapiens (human) | IC50 | 3.6800 | 1 | 1 |
| mimosine | Homo sapiens (human) | Ki | 10.3000 | 1 | 1 |
| arbutin | Homo sapiens (human) | IC50 | 6,489.4086 | 7 | 7 |
| resveratrol | Homo sapiens (human) | IC50 | 985.1750 | 4 | 4 |
| glabrene | Homo sapiens (human) | IC50 | 7.5000 | 1 | 1 |
| glyasperin D | Homo sapiens (human) | IC50 | 0.1540 | 1 | 1 |
| 6-hydroxyindole | Homo sapiens (human) | IC50 | 22.0000 | 1 | 1 |
| trans-4-coumaric acid | Homo sapiens (human) | IC50 | 2.3333 | 3 | 3 |
| phenylthiourea | Homo sapiens (human) | IC50 | 1.8000 | 1 | 1 |
| phenylthiourea | Homo sapiens (human) | Ki | 1.7000 | 1 | 1 |
| isoeugenol | Homo sapiens (human) | IC50 | 33.3300 | 1 | 1 |
| curcumin | Homo sapiens (human) | IC50 | 5.0000 | 1 | 1 |
| 4-hydroxy-5-methyl-3(2h)-furanone | Homo sapiens (human) | IC50 | 50.0000 | 1 | 1 |
| quercetin | Homo sapiens (human) | IC50 | 44.3800 | 1 | 1 |
| luteolin | Homo sapiens (human) | IC50 | 60.0000 | 1 | 1 |
| apigetrin | Homo sapiens (human) | IC50 | 50.0000 | 1 | 1 |
| quercetin 3-o-glucopyranoside | Homo sapiens (human) | IC50 | 50.0000 | 1 | 1 |
| kaempferol | Homo sapiens (human) | IC50 | 33.0550 | 2 | 2 |
| hispidol | Homo sapiens (human) | IC50 | 38.4000 | 1 | 1 |
| 7-hydroxycoumarin | Homo sapiens (human) | IC50 | 420.0000 | 1 | 1 |
| euxanthone | Homo sapiens (human) | IC50 | 4.5200 | 1 | 1 |
| trans-2,3',4,5'-tetrahydroxystilbene | Homo sapiens (human) | IC50 | 6.7967 | 3 | 3 |
| linarin | Homo sapiens (human) | IC50 | 50.0000 | 1 | 1 |
| methyl-p-coumarate | Homo sapiens (human) | IC50 | 30.0000 | 2 | 2 |
| tiliroside | Homo sapiens (human) | IC50 | 78.5300 | 1 | 1 |
| tilianin | Homo sapiens (human) | IC50 | 50.0000 | 1 | 1 |
| 2,4,3',5'-tetramethoxystilbene | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| 1-hydroxyxanthone | Homo sapiens (human) | IC50 | 8.8300 | 1 | 1 |
| Norartocarpetin | Homo sapiens (human) | IC50 | 0.0230 | 1 | 1 |
| 3,4-dihydroxy-xanthone | Homo sapiens (human) | IC50 | 5.1200 | 1 | 1 |
| hylin | Homo sapiens (human) | IC50 | 250.0000 | 1 | 1 |
| apigenin-7-o-rutinoside | Homo sapiens (human) | IC50 | 50.0000 | 1 | 1 |
| morachalcone a | Homo sapiens (human) | IC50 | 0.0800 | 1 | 1 |
| 2,4,2',4'-Tetrahydroxychalcone | Homo sapiens (human) | IC50 | 0.0700 | 1 | 1 |
| 4-(1-phenylethyl)resorcinol | Homo sapiens (human) | IC50 | 131.0000 | 1 | 1 |
| 4-(1-phenylethyl)resorcinol | Homo sapiens (human) | Ki | 24.0000 | 1 | 1 |
| 3-hydroxyphloretin | Homo sapiens (human) | IC50 | 32.0000 | 1 | 1 |
| subamolide a | Homo sapiens (human) | IC50 | 1.0000 | 1 | 1 |
| feruloyldopamine | Homo sapiens (human) | IC50 | 50.0000 | 1 | 1 |
| ascorbic acid | Homo sapiens (human) | IC50 | 32.5000 | 1 | 1 |
Drugs with Other Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| kojic acid | Homo sapiens (human) | Km | 79.0000 | 4 | 4 |
Enables
This protein enables 5 target(s):
| Target | Category | Definition |
|---|---|---|
| tyrosinase activity | molecular function | Catalysis of the reaction: L-tyrosine + O2 = L-DOPAquinone + H2O. This reaction can use both monophenols (such as tyrosine) and catechols (o-diphenols) as substrates. [PMID:4965136, RHEA:18117] |
| copper ion binding | molecular function | Binding to a copper (Cu) ion. [GOC:ai] |
| protein binding | molecular function | Binding to a protein. [GOC:go_curators] |
| identical protein binding | molecular function | Binding to an identical protein or proteins. [GOC:jl] |
| protein homodimerization activity | molecular function | Binding to an identical protein to form a homodimer. [GOC:jl] |
Located In
This protein is located in 7 target(s):
| Target | Category | Definition |
|---|---|---|
| cytoplasm | cellular component | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684] |
| lysosome | cellular component | A small lytic vacuole that has cell cycle-independent morphology found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions. [GOC:mah, ISBN:0198506732] |
| Golgi-associated vesicle | cellular component | Any vesicle associated with the Golgi complex and involved in mediating transport within the Golgi or between the Golgi and other parts of the cell. [GOC:mah] |
| melanosome membrane | cellular component | The lipid bilayer surrounding a melanosome. [GOC:mah] |
| melanosome | cellular component | A tissue-specific, membrane-bounded cytoplasmic organelle within which melanin pigments are synthesized and stored. Melanosomes are synthesized in melanocyte cells. [GOC:jl, PMID:11584301] |
| intracellular membrane-bounded organelle | cellular component | Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane. [GOC:go_curators] |
| perinuclear region of cytoplasm | cellular component | Cytoplasm situated near, or occurring around, the nucleus. [GOC:jid] |
Involved In
This protein is involved in 11 target(s):
| Target | Category | Definition |
|---|---|---|
| melanin biosynthetic process from tyrosine | biological process | The chemical reactions and pathways resulting in the formation of melanin from other compounds, including tyrosine. [GOC:go_curators] |
| eye pigment biosynthetic process | biological process | The chemical reactions and pathways resulting in the formation of eye pigments, any general or particular coloring matter in living organisms, found or utilized in the eye. [GOC:ai] |
| visual perception | biological process | The series of events required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual stimuli are detected in the form of photons and are processed to form an image. [GOC:ai] |
| cell population proliferation | biological process | The multiplication or reproduction of cells, resulting in the expansion of a cell population. [GOC:mah, GOC:mb] |
| response to UV | biological process | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ultraviolet radiation (UV light) stimulus. Ultraviolet radiation is electromagnetic radiation with a wavelength in the range of 10 to 380 nanometers. [GOC:hb] |
| response to blue light | biological process | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a blue light stimulus. Blue light is electromagnetic radiation with a wavelength of between 440 and 500nm. [GOC:ai, GOC:mtg_far_red] |
| response to vitamin D | biological process | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin D stimulus. [GOC:sl] |
| melanin biosynthetic process | biological process | The chemical reactions and pathways resulting in the formation of melanins, pigments largely of animal origin. High molecular weight polymers of indole quinone, they are irregular polymeric structures and are divided into three groups: allomelanins in the plant kingdom and eumelanins and phaeomelanins in the animal kingdom. [GOC:curators] |
| thymus development | biological process | The process whose specific outcome is the progression of the thymus over time, from its formation to the mature structure. The thymus is a symmetric bi-lobed organ involved primarily in the differentiation of immature to mature T cells, with unique vascular, nervous, epithelial, and lymphoid cell components. [GOC:add, ISBN:0781735149] |
| response to cAMP | biological process | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate) stimulus. [GOC:ai] |
| pigmentation | biological process | The accumulation of pigment in an organism, tissue or cell, either by increased deposition or by increased number of cells. [GOC:jl] |