Phosphatidylinositol 3-kinase catalytic subunit type 3

A phosphatidylinositol 3-kinase catalytic subunit type 3 that is encoded in the genome of human. [PRO:DNx]

Synonyms

PI3-kinase type 3;
PI3K type 3;
PtdIns-3-kinase type 3;
EC 2.7.1.137;
Phosphatidylinositol 3-kinase p100 subunit;
Phosphoinositide-3-kinase class 3;
hVps34

Research

Bioassay Publications (19)

Timeframe	Studies on this Protein(%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	1 (5.26)	29.6817
2010's	17 (89.47)	24.3611
2020's	1 (5.26)	2.80

Compounds (23)

Drugs with Inhibition Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
ML162	Homo sapiens (human)	IC50	0.0215	2	2
PI3-Kinase alpha Inhibitor 2	Homo sapiens (human)	IC50	0.0080	1	1
idelalisib	Homo sapiens (human)	IC50	327.7990	3	3
zstk474	Homo sapiens (human)	IC50	100.0000	1	1
dactolisib	Homo sapiens (human)	IC50	0.4500	1	1
ku 60019	Homo sapiens (human)	IC50	0.0170	1	1
buparlisib	Homo sapiens (human)	IC50	2.4905	2	2
gdc 0941	Homo sapiens (human)	IC50	11.3627	3	10
gdc 0980	Homo sapiens (human)	IC50	2.0000	1	1
ch 5132799	Homo sapiens (human)	IC50	10.0000	1	1
torin 1	Homo sapiens (human)	IC50	0.5330	1	1
gdc-0032	Homo sapiens (human)	IC50	0.3740	2	1
spautin-1	Homo sapiens (human)	IC50	0.7400	1	1
torin 2	Homo sapiens (human)	IC50	0.0086	1	1
cudc-907	Homo sapiens (human)	IC50	10.0000	1	1
sar245408	Homo sapiens (human)	IC50	7.0000	1	1
byl719	Homo sapiens (human)	IC50	9.1000	1	1
amg 511	Homo sapiens (human)	IC50	10.0000	1	1
sar405	Homo sapiens (human)	IC50	0.0076	4	4

Drugs with Activation Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
ku 60019	Homo sapiens (human)	Kd	0.0017	1	1
buparlisib	Homo sapiens (human)	Kd	0.2000	1	1
gdc 0980	Homo sapiens (human)	Kd	0.2500	1	1
azd2014	Homo sapiens (human)	Kd	23.0000	1	1
pki 587	Homo sapiens (human)	Kd	5.1000	1	1
5-(4-amino-1-propan-2-yl-3-pyrazolo[3,4-d]pyrimidinyl)-1,3-benzoxazol-2-amine	Homo sapiens (human)	Kd	8.2000	1	1
cc-223	Homo sapiens (human)	Kd	2.5000	1	1

Enables

This protein enables 6 target(s):

Target	Category	Definition
protein kinase activity	molecular function	Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. [PMID:25399640]
protein binding	molecular function	Binding to a protein. [GOC:go_curators]
ATP binding	molecular function	Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. [ISBN:0198506732]
kinase activity	molecular function	Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. [ISBN:0198506732]
1-phosphatidylinositol-3-kinase activity	molecular function	Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol + ATP = a 1-phosphatidyl-1D-myo-inositol 3-phosphate + ADP + 2 H+. [EC:2.7.1.137, RHEA:12709]
phosphatidylinositol kinase activity	molecular function	Catalysis of the reaction: ATP + a phosphatidylinositol = ADP + a phosphatidylinositol phosphate. [GOC:ai]

Located In

This protein is located in 8 target(s):

Target	Category	Definition
late endosome	cellular component	A prelysosomal endocytic organelle differentiated from early endosomes by lower lumenal pH and different protein composition. Late endosomes are more spherical than early endosomes and are mostly juxtanuclear, being concentrated near the microtubule organizing center. [NIF_Subcellular:nlx_subcell_20090702, PMID:11964142, PMID:2557062]
autophagosome	cellular component	A double-membrane-bounded compartment that engulfs endogenous cellular material as well as invading microorganisms to target them to the lytic vacuole/lysosome for degradation as part of macroautophagy. [GOC:autophagy, ISBN:0198547684, PMID:11099404]
cytosol	cellular component	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]
axoneme	cellular component	The bundle of microtubules and associated proteins that forms the core of cilia (also called flagella) in eukaryotic cells and is responsible for their movements. [GOC:bf, GOC:cilia, ISBN:0198547684]
membrane	cellular component	A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. [GOC:dos, GOC:mah, ISBN:0815316194]
midbody	cellular component	A thin cytoplasmic bridge formed between daughter cells at the end of cytokinesis. The midbody forms where the contractile ring constricts, and may persist for some time before finally breaking to complete cytokinesis. [ISBN:0815316194]
phagocytic vesicle membrane	cellular component	The lipid bilayer surrounding a phagocytic vesicle. [GOC:mah]
autolysosome	cellular component	A type of secondary lysosome in which a primary lysosome has fused with the outer membrane of an autophagosome or amphisome. It is involved in the second step of autophagy in which it degrades contents with acidic lysosomal hydrolases. [GOC:sart, NIF_Subcellular:sao8444068431, PMID:19008921, PMID:24657946]

Active In

This protein is active in 5 target(s):

Target	Category	Definition
peroxisome	cellular component	A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism. [GOC:pm, PMID:9302272, UniProtKB-KW:KW-0576]
endosome	cellular component	A vacuole to which materials ingested by endocytosis are delivered. [ISBN:0198506732, PMID:19696797]
membrane	cellular component	A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. [GOC:dos, GOC:mah, ISBN:0815316194]
phagophore assembly site	cellular component	Punctate structures proximal to the endoplasmic reticulum which are the sites where the Atg machinery assembles upon autophagy induction. [GOC:elh, PMID:11689437, PMID:12048214, PMID:12554655]
cytoplasm	cellular component	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684]

Part Of

This protein is part of 3 target(s):

Target	Category	Definition
phosphatidylinositol 3-kinase complex, class III	cellular component	A phosphatidylinositol 3-kinase complex that contains a catalytic class III phosphoinositide 3-kinase (PI3K) subunit bound to a regulatory (adaptor) subunit. Additional adaptor proteins may be present. Class III PI3Ks have a substrate specificity restricted to phosphatidylinositol (PI). [GOC:bf, PMID:9255069]
phosphatidylinositol 3-kinase complex, class III, type II	cellular component	A class III phosphatidylinositol 3-kinase complex that is involved in vacuolar protein sorting (VPS) via endosomes. In budding yeast, this complex consists of Vps30p, Vps34p, Vps38 and Vps15p. [GOC:ha, GOC:rb, PMID:11157979, PMID:16421251]
phosphatidylinositol 3-kinase complex, class III, type I	cellular component	A class III phosphatidylinositol 3-kinase complex that is involved in autophagy. In budding yeast, this complex consists of Vps30p, Vps34p, Apg14p and Vps15p. [GOC:ha, GOC:rb, PMID:11157979, PMID:16421251]

Involved In

This protein is involved in 17 target(s):

Target	Category	Definition
autophagosome assembly	biological process	The formation of a double membrane-bounded structure, the autophagosome, that occurs when a specialized membrane sac, called the isolation membrane, starts to enclose a portion of the cytoplasm. [GOC:autophagy, PMID:9412464]
protein targeting to lysosome	biological process	The process of directing proteins towards the lysosome using signals contained within the protein. [GOC:curators]
regulation of autophagy	biological process	Any process that modulates the frequency, rate or extent of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm. [GOC:dph, GOC:tb]
macroautophagy	biological process	The autophagic process that proceeds via the formation of an autophagosome. [PMID:24366339]
regulation of macroautophagy	biological process	Any process that modulates the frequency, rate or extent of macroautophagy. [GOC:krc]
regulation of cytokinesis	biological process	Any process that modulates the frequency, rate or extent of the division of the cytoplasm of a cell and its separation into two daughter cells. [GOC:mah]
protein localization to phagophore assembly site	biological process	Any process in which a protein is transported to, or maintained at, the phagophore assembly site (PAS). [GOC:rb]
phosphatidylinositol-3-phosphate biosynthetic process	biological process	The chemical reactions and pathways resulting in the formation of phosphatidylinositol-3-phosphate, a phosphatidylinositol monophosphate carrying the phosphate group at the 3-position. [GOC:al, GOC:vw]
cellular response to glucose starvation	biological process	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of glucose. [GOC:jl]
positive regulation by host of viral genome replication	biological process	A process in which a host organism activates or increases the frequency, rate or extent of viral genome replication. [GOC:jl]
early endosome to late endosome transport	biological process	The directed movement of substances, in membrane-bounded vesicles, from the early sorting endosomes to the late sorting endosomes; transport occurs along microtubules and can be experimentally blocked with microtubule-depolymerizing drugs. [ISBN:0815316194, PMID:29980602]
phosphatidylinositol phosphate biosynthetic process	biological process	The chemical reactions and pathways resulting in the formation of phosphatidylinositol phosphate. [ISBN:0198506732]
cell division	biological process	The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells. [GOC:di, GOC:go_curators, GOC:pr]
autophagosome maturation	biological process	Removal of PI3P and Atg8/LC3 after the closure of the phagophore and before the fusion with the endosome/lysosome (e.g. mammals and insects) or vacuole (yeast), and that very likely destabilizes other Atg proteins and thus enables their efficient dissociation and recycling. [GOC:autophagy, GOC:lf, PMID:28077293]
autophagy of peroxisome	biological process	The process in which peroxisomes are delivered to a type of vacuole and degraded in response to changing nutrient conditions. [GOC:autophagy, PMID:10547367, PMID:20083110]
endocytosis	biological process	A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a part of the plasma membrane to form a new membrane-bounded vesicle. [GOC:mah, ISBN:0198506732, ISBN:0716731363, Wikipedia:Endocytosis]
phosphatidylinositol-mediated signaling	biological process	The series of molecular signals in which a cell uses a phosphatidylinositol-mediated signaling to convert a signal into a response. Phosphatidylinositols include phosphatidylinositol (PtdIns) and its phosphorylated derivatives. [GOC:bf, GOC:ceb, ISBN:0198506732]

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