Page last updated: 2024-08-07 20:39:14

Forkhead box protein M1

A forkhead box protein M1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q08050]

Synonyms

Forkhead-related protein FKHL16;
Hepatocyte nuclear factor 3 forkhead homolog 11;
HFH-11;
HNF-3/fork-head homolog 11;
M-phase phosphoprotein 2;
MPM-2 reactive phosphoprotein 2;
Transcription factor Trident;
Winged-helix factor

Research

Bioassay Publications (2)

TimeframeStudies on this Protein(%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's2 (100.00)2.80

Compounds (2)

Drugs with Inhibition Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
troglitazoneHomo sapiens (human)IC50122.400011
troglitazoneHomo sapiens (human)Ki0.052011
ncgc00099374Homo sapiens (human)IC5028.400011
ncgc00099374Homo sapiens (human)Ki0.143010

Enables

This protein enables 5 target(s):

TargetCategoryDefinition
RNA polymerase II transcription regulatory region sequence-specific DNA bindingmolecular functionBinding to a specific sequence of DNA that is part of a regulatory region that controls the transcription of a gene or cistron by RNA polymerase II. [GOC:txnOH]
DNA-binding transcription factor activity, RNA polymerase II-specificmolecular functionA DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II. [GOC:txnOH-2018]
protein bindingmolecular functionBinding to a protein. [GOC:go_curators]
protein kinase bindingmolecular functionBinding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate. [GOC:jl]
DNA-binding transcription factor activitymolecular functionA transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. [GOC:txnOH-2018]

Located In

This protein is located in 1 target(s):

TargetCategoryDefinition
nucleoplasmcellular componentThat part of the nuclear content other than the chromosomes or the nucleolus. [GOC:ma, ISBN:0124325653]

Active In

This protein is active in 1 target(s):

TargetCategoryDefinition
nucleuscellular componentA membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators]

Part Of

This protein is part of 1 target(s):

TargetCategoryDefinition
chromatincellular componentThe ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome. [GOC:elh, PMID:20404130]

Involved In

This protein is involved in 14 target(s):

TargetCategoryDefinition
G2/M transition of mitotic cell cyclebiological processThe mitotic cell cycle transition by which a cell in G2 commits to M phase. The process begins when the kinase activity of M cyclin/CDK complex reaches a threshold high enough for the cell cycle to proceed. This is accomplished by activating a positive feedback loop that results in the accumulation of unphosphorylated and active M cyclin/CDK complex. [GOC:mtg_cell_cycle]
negative regulation of transcription by RNA polymerase IIbiological processAny process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II. [GOC:go_curators, GOC:txnOH]
DNA repairbiological processThe process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. [PMID:11563486]
DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorbiological processA cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, resulting in the induction of the transcription of p21 (also known as WAF1, CIP1 and SDI1) or any equivalent protein, in response to the detection of DNA damage. [PMID:10967424]
positive regulation of cell population proliferationbiological processAny process that activates or increases the rate or extent of cell proliferation. [GOC:go_curators]
negative regulation of stress-activated MAPK cascadebiological processAny process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the stress-activated MAPK cascade. [GOC:mah]
negative regulation of DNA-templated transcriptionbiological processAny process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription. [GOC:go_curators, GOC:txnOH]
positive regulation of DNA-templated transcriptionbiological processAny process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription. [GOC:go_curators, GOC:txnOH]
positive regulation of transcription by RNA polymerase IIbiological processAny process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter. [GOC:go_curators, GOC:txnOH]
regulation of Ras protein signal transductionbiological processAny process that modulates the frequency, rate or extent of Ras protein signal transduction. [GOC:bf]
regulation of reactive oxygen species metabolic processbiological processAny process that modulates the frequency, rate or extent of reactive oxygen species metabolic process. [GOC:mah]
positive regulation of double-strand break repairbiological processAny process that activates or increases the frequency, rate or extent of double-strand break repair. [GOC:BHF]
regulation of cell population proliferationbiological processAny process that modulates the frequency, rate or extent of cell proliferation. [GOC:jl]
regulation of transcription by RNA polymerase IIbiological processAny process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II. [GOC:go_curators, GOC:txnOH]