Page last updated: 2024-08-07 16:22:34
Adenosine receptor A2b
An adenosine receptor A2b that is encoded in the genome of rat. [PRO:WCB]
Synonyms
Research
Bioassay Publications (50)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 15 (30.00) | 18.7374 |
| 1990's | 25 (50.00) | 18.2507 |
| 2000's | 6 (12.00) | 29.6817 |
| 2010's | 4 (8.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Compounds (121)
Drugs with Potency Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| ml106 | Rattus norvegicus (Norway rat) | Potency | 0.0708 | 1 | 0 |
| 6-(1,3-benzodioxol-5-yl)-N-(2-furanylmethyl)-N-methyl-4-quinazolinamine | Rattus norvegicus (Norway rat) | Potency | 0.0631 | 1 | 0 |
| N-(2-furanylmethyl)-6-(3-methoxyphenyl)-N-methyl-4-quinazolinamine | Rattus norvegicus (Norway rat) | Potency | 0.3548 | 1 | 0 |
| 6-(1,3-benzodioxol-5-yl)-N-[(3-methylphenyl)methyl]-4-quinazolinamine | Rattus norvegicus (Norway rat) | Potency | 0.1122 | 1 | 0 |
| 6-(2-chlorophenyl)-N-(3-pyridinylmethyl)-4-quinazolinamine | Rattus norvegicus (Norway rat) | Potency | 12.5893 | 1 | 0 |
| 6-(3-furanyl)-N-[(3-methylphenyl)methyl]-4-quinazolinamine | Rattus norvegicus (Norway rat) | Potency | 0.2512 | 1 | 0 |
| 6-(3-pyridinyl)-N-(3-pyridinylmethyl)-4-quinazolinamine | Rattus norvegicus (Norway rat) | Potency | 7.9433 | 1 | 0 |
| 6-(3-furanyl)-N-(thiophen-2-ylmethyl)-4-quinazolinamine | Rattus norvegicus (Norway rat) | Potency | 0.2239 | 1 | 0 |
| 6-(3-methoxyphenyl)-N-(3-pyridinylmethyl)-4-quinazolinamine | Rattus norvegicus (Norway rat) | Potency | 2.5119 | 1 | 0 |
| 6-(2-chlorophenyl)-N-(2-furanylmethyl)-N-methyl-4-quinazolinamine | Rattus norvegicus (Norway rat) | Potency | 10.0000 | 1 | 0 |
| 6-(3-methoxyphenyl)-N-(thiophen-2-ylmethyl)-4-quinazolinamine | Rattus norvegicus (Norway rat) | Potency | 1.0000 | 1 | 0 |
| 6-(3-furanyl)-N-(3-pyridinylmethyl)-4-quinazolinamine | Rattus norvegicus (Norway rat) | Potency | 0.5623 | 1 | 0 |
| N-[(3-methylphenyl)methyl]-6-(3-pyridinyl)-4-quinazolinamine | Rattus norvegicus (Norway rat) | Potency | 2.8184 | 1 | 0 |
| N-(2-furanylmethyl)-N-methyl-6-(1-methyl-5-indolyl)-4-quinazolinamine | Rattus norvegicus (Norway rat) | Potency | 14.1254 | 1 | 0 |
| 6-(2-chlorophenyl)-N-[(3-methylphenyl)methyl]-4-quinazolinamine | Rattus norvegicus (Norway rat) | Potency | 7.9433 | 1 | 0 |
| 6-(3-methoxyphenyl)-N-[(3-methylphenyl)methyl]-4-quinazolinamine | Rattus norvegicus (Norway rat) | Potency | 1.2589 | 1 | 0 |
| 6-(2,3-dihydro-1,4-benzodioxin-6-yl)-N-[(3-methylphenyl)methyl]-4-quinazolinamine | Rattus norvegicus (Norway rat) | Potency | 0.5623 | 1 | 0 |
| 6-(2-chlorophenyl)-N-(thiophen-2-ylmethyl)-4-quinazolinamine | Rattus norvegicus (Norway rat) | Potency | 6.3096 | 1 | 0 |
| 6-(3-chlorophenyl)-N-(thiophen-2-ylmethyl)-4-quinazolinamine | Rattus norvegicus (Norway rat) | Potency | 3.9811 | 1 | 0 |
| 6-(3-pyridinyl)-N-(thiophen-2-ylmethyl)-4-quinazolinamine | Rattus norvegicus (Norway rat) | Potency | 3.1623 | 1 | 0 |
| 6-(3-methylphenyl)-N-(thiophen-2-ylmethyl)-4-quinazolinamine | Rattus norvegicus (Norway rat) | Potency | 7.9433 | 1 | 0 |
| 6-(1-methyl-5-indolyl)-N-(thiophen-2-ylmethyl)-4-quinazolinamine | Rattus norvegicus (Norway rat) | Potency | 14.1254 | 1 | 0 |
| 6-(2,3-dihydro-1,4-benzodioxin-6-yl)-N-(thiophen-2-ylmethyl)-4-quinazolinamine | Rattus norvegicus (Norway rat) | Potency | 0.1413 | 1 | 0 |
| N-(1,3-benzodioxol-5-ylmethyl)-6-(2,3-dihydro-1,4-benzodioxin-6-yl)-4-quinazolinamine | Rattus norvegicus (Norway rat) | Potency | 1.7783 | 1 | 0 |
| 6-(2,3-dihydro-1,4-benzodioxin-6-yl)-N-(3-pyridinylmethyl)-4-quinazolinamine | Rattus norvegicus (Norway rat) | Potency | 0.3981 | 1 | 0 |
| 6-(1,3-benzodioxol-5-yl)-N-[(3-fluorophenyl)methyl]-4-quinazolinamine | Rattus norvegicus (Norway rat) | Potency | 0.1413 | 1 | 0 |
| 6-(3-chlorophenyl)-N-(3-pyridinylmethyl)-4-quinazolinamine | Rattus norvegicus (Norway rat) | Potency | 4.4668 | 1 | 0 |
| 6-(3-methylphenyl)-N-(3-pyridinylmethyl)-4-quinazolinamine | Rattus norvegicus (Norway rat) | Potency | 6.3096 | 1 | 0 |
| 6-(1,3-benzodioxol-5-yl)-N-(3-pyridinylmethyl)-4-quinazolinamine | Rattus norvegicus (Norway rat) | Potency | 0.1259 | 1 | 0 |
| N-(1,3-benzodioxol-5-ylmethyl)-6-(2-chlorophenyl)-4-quinazolinamine | Rattus norvegicus (Norway rat) | Potency | 14.1254 | 1 | 0 |
| N-(1,3-benzodioxol-5-ylmethyl)-6-(3-methoxyphenyl)-4-quinazolinamine | Rattus norvegicus (Norway rat) | Potency | 1.2589 | 1 | 0 |
| N-(1,3-benzodioxol-5-ylmethyl)-6-(3-pyridinyl)-4-quinazolinamine | Rattus norvegicus (Norway rat) | Potency | 7.0795 | 1 | 0 |
| N-(1,3-benzodioxol-5-ylmethyl)-6-(3-furanyl)-4-quinazolinamine | Rattus norvegicus (Norway rat) | Potency | 0.7079 | 1 | 0 |
| 6-(2-chlorophenyl)-N-[(4-methyl-2-thiophenyl)methyl]-4-quinazolinamine | Rattus norvegicus (Norway rat) | Potency | 8.9125 | 1 | 0 |
| 6-(3-chlorophenyl)-N-[(4-methyl-2-thiophenyl)methyl]-4-quinazolinamine | Rattus norvegicus (Norway rat) | Potency | 12.5893 | 1 | 0 |
| 6-(3-methoxyphenyl)-N-[(4-methyl-2-thiophenyl)methyl]-4-quinazolinamine | Rattus norvegicus (Norway rat) | Potency | 0.8913 | 1 | 0 |
| N-[(4-methyl-2-thiophenyl)methyl]-6-(3-pyridinyl)-4-quinazolinamine | Rattus norvegicus (Norway rat) | Potency | 4.4668 | 1 | 0 |
| 6-(1,3-benzodioxol-5-yl)-N-[(4-methyl-2-thiophenyl)methyl]-4-quinazolinamine | Rattus norvegicus (Norway rat) | Potency | 0.1585 | 1 | 0 |
| 6-(2,3-dihydro-1,4-benzodioxin-6-yl)-N-[(4-methyl-2-thiophenyl)methyl]-4-quinazolinamine | Rattus norvegicus (Norway rat) | Potency | 0.4467 | 1 | 0 |
| 6-(3-furanyl)-N-[(4-methyl-2-thiophenyl)methyl]-4-quinazolinamine | Rattus norvegicus (Norway rat) | Potency | 0.5623 | 1 | 0 |
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| 9-ethyladenine | Rattus norvegicus (Norway rat) | Ki | 5.6000 | 1 | 1 |
| xanthine | Rattus norvegicus (Norway rat) | Ki | 130.0000 | 1 | 1 |
| 1,3-diethyl-8-phenylxanthine | Rattus norvegicus (Norway rat) | Ki | 0.8360 | 1 | 1 |
| 1,3-dipropyl-8-cyclopentylxanthine | Rattus norvegicus (Norway rat) | Ki | 0.3352 | 11 | 16 |
| 1,3-dipropyl-8-(4-sulfophenyl)xanthine | Rattus norvegicus (Norway rat) | Ki | 5.3020 | 3 | 5 |
| enprofylline | Rattus norvegicus (Norway rat) | Ki | 124.6000 | 3 | 5 |
| 7-(2-chloroethyl)theophylline | Rattus norvegicus (Norway rat) | Ki | 5.3900 | 1 | 1 |
| 8-(4-sulfophenyl)theophylline | Rattus norvegicus (Norway rat) | Ki | 5.2500 | 2 | 4 |
| 8-cyclopentyl-1,3-dimethylxanthine | Rattus norvegicus (Norway rat) | Ki | 0.5733 | 2 | 3 |
| 8-phenyltheophylline | Rattus norvegicus (Norway rat) | IC50 | 1.1000 | 1 | 1 |
| 8-phenyltheophylline | Rattus norvegicus (Norway rat) | Ki | 1.2510 | 5 | 8 |
| theophylline | Rattus norvegicus (Norway rat) | Ki | 15.3896 | 18 | 24 |
| caffeine | Rattus norvegicus (Norway rat) | IC50 | 63.0000 | 1 | 5 |
| caffeine | Rattus norvegicus (Norway rat) | Ki | 35.3050 | 15 | 20 |
| cgs 15943 | Rattus norvegicus (Norway rat) | IC50 | 0.0028 | 1 | 5 |
| 1-methyl-3-isobutylxanthine | Rattus norvegicus (Norway rat) | IC50 | 13.0000 | 1 | 5 |
| 1-methyl-3-isobutylxanthine | Rattus norvegicus (Norway rat) | Ki | 6.1500 | 6 | 9 |
| n 0840 | Rattus norvegicus (Norway rat) | Ki | 25.0000 | 1 | 1 |
| rolipram | Rattus norvegicus (Norway rat) | IC50 | 100.0000 | 1 | 5 |
| sq 22536 | Rattus norvegicus (Norway rat) | Ki | 2.4000 | 1 | 1 |
| theobromine | Rattus norvegicus (Norway rat) | Ki | 250.0000 | 2 | 3 |
| 8-(4-((2-aminoethyl)aminocarbonylmethyloxy)phenyl)-1,3-dipropylxanthine | Rattus norvegicus (Norway rat) | Ki | 0.0420 | 3 | 4 |
| 2-chloroadenosine | Rattus norvegicus (Norway rat) | IC50 | 0.1600 | 1 | 2 |
| 2-chloroadenosine | Rattus norvegicus (Norway rat) | Ki | 0.1880 | 5 | 6 |
| cyproterone acetate | Rattus norvegicus (Norway rat) | Ki | 0.3360 | 1 | 3 |
| toyocamycin | Rattus norvegicus (Norway rat) | IC50 | 3,235,940.0000 | 1 | 1 |
| nsc 65346 | Rattus norvegicus (Norway rat) | IC50 | 2,137,960.0000 | 1 | 1 |
| adenosine | Rattus norvegicus (Norway rat) | Ki | 0.0210 | 2 | 2 |
| rolofylline | Rattus norvegicus (Norway rat) | Ki | 0.4450 | 2 | 2 |
| isoguanosine | Rattus norvegicus (Norway rat) | Ki | 0.3300 | 1 | 1 |
| 9-methyladenine | Rattus norvegicus (Norway rat) | Ki | 24.0000 | 1 | 1 |
| 3-methylxanthine | Rattus norvegicus (Norway rat) | Ki | 240.0000 | 1 | 2 |
| 1-methylxanthine | Rattus norvegicus (Norway rat) | Ki | 20.8800 | 3 | 5 |
| n(6)-benzyladenosine | Rattus norvegicus (Norway rat) | Ki | 0.2800 | 1 | 1 |
| 1,3-dipropyl-8-(2-amino-4-chlorophenyl)xanthine | Rattus norvegicus (Norway rat) | Ki | 1.0000 | 1 | 1 |
| phenylisopropyladenosine | Rattus norvegicus (Norway rat) | IC50 | 0.2898 | 2 | 4 |
| phenylisopropyladenosine | Rattus norvegicus (Norway rat) | Ki | 2.6838 | 11 | 12 |
| bromotubercidin | Rattus norvegicus (Norway rat) | IC50 | 8,317,640.0000 | 1 | 1 |
| 5-iodotubercidin | Rattus norvegicus (Norway rat) | IC50 | 38,904,500.0000 | 1 | 1 |
| 5-chlorotubercidin | Rattus norvegicus (Norway rat) | IC50 | 4,786,300.0000 | 1 | 1 |
| 5'-n-methylcarboxamideadenosine | Rattus norvegicus (Norway rat) | Ki | 0.0668 | 1 | 2 |
| n(6)-phenyladenosine | Rattus norvegicus (Norway rat) | IC50 | 0.6600 | 1 | 1 |
| n(6)-phenyladenosine | Rattus norvegicus (Norway rat) | Ki | 25.6000 | 2 | 2 |
| bw a1433u | Rattus norvegicus (Norway rat) | Ki | 0.2500 | 2 | 3 |
| n-(2-(dimethylamino)ethyl)-n-methyl-4-(2,3,6,7-tetrahydro-2,6-dioxo-1,3-dipropyl-1h-purin-8-yl)benzenesulfonamide | Rattus norvegicus (Norway rat) | Ki | 0.0225 | 2 | 3 |
| n(6)-(3-iodobenzyl)-5'-n-methylcarboxamidoadenosine | Rattus norvegicus (Norway rat) | Ki | 0.0560 | 1 | 2 |
| 2-chloro-n(6)cyclopentyladenosine | Rattus norvegicus (Norway rat) | Ki | 0.9500 | 1 | 1 |
| cp 66713 | Rattus norvegicus (Norway rat) | IC50 | 0.0210 | 1 | 5 |
| 8-(4-carboxymethyloxy)phenyl-1,3-dipropylxanthine | Rattus norvegicus (Norway rat) | Ki | 2.2000 | 1 | 1 |
| 1-propylxanthine | Rattus norvegicus (Norway rat) | Ki | 22.6267 | 2 | 3 |
| 1,3-dipropyl-8-phenylxanthine | Rattus norvegicus (Norway rat) | Ki | 1.0691 | 6 | 11 |
| 8-(dicyclopropylmethyl)-1,3-dipropylxanthine | Rattus norvegicus (Norway rat) | Ki | 0.4300 | 3 | 3 |
| kfm 19 | Rattus norvegicus (Norway rat) | Ki | 2.7000 | 1 | 1 |
| 8-cyclopentyl-3-(3-((4-(fluorosulfonyl)benzoyl)oxy)propyl)-1-propylxanthine | Rattus norvegicus (Norway rat) | IC50 | 9.0000 | 1 | 1 |
| 2-(1-octynyl)adenosine | Rattus norvegicus (Norway rat) | Ki | 0.0067 | 3 | 6 |
| 1-isoamyl-3-isobutylxanthine | Rattus norvegicus (Norway rat) | Ki | 6.5000 | 1 | 2 |
| 1-deazaadenosine | Rattus norvegicus (Norway rat) | Ki | 2.9000 | 1 | 1 |
| 1,3-dipropyl-7-methylxanthine | Rattus norvegicus (Norway rat) | Ki | 6.0333 | 3 | 6 |
| 2-hexynyladenosine-5'-n-ethylcarboxamide | Rattus norvegicus (Norway rat) | Ki | 0.0045 | 2 | 4 |
| 1,3-dipropylxanthine | Rattus norvegicus (Norway rat) | Ki | 4.7500 | 8 | 12 |
| sch 58261 | Rattus norvegicus (Norway rat) | Ki | 1.0000 | 1 | 1 |
| 8-cyclohexylcaffeine | Rattus norvegicus (Norway rat) | Ki | 2.1450 | 2 | 4 |
| adenosine-5'-(n-ethylcarboxamide) | Rattus norvegicus (Norway rat) | IC50 | 0.0175 | 3 | 8 |
| adenosine-5'-(n-ethylcarboxamide) | Rattus norvegicus (Norway rat) | Ki | 0.2480 | 7 | 11 |
| 1-deaza-2-chloro-n(6)-cyclopentyladenosine | Rattus norvegicus (Norway rat) | Ki | 13.2000 | 1 | 1 |
| n(6)-cyclopentyladenosine | Rattus norvegicus (Norway rat) | IC50 | 1.1600 | 1 | 2 |
| n(6)-cyclopentyladenosine | Rattus norvegicus (Norway rat) | Ki | 0.8668 | 7 | 8 |
| 2-((2-aminoethylamino)carbonylethylphenylethylamino)-5'-n-ethylcarboxamidoadenosine | Rattus norvegicus (Norway rat) | Ki | 0.0057 | 1 | 2 |
| 2-(4-(2-carboxyethyl)phenethylamino)-5'-n-ethylcarboxamidoadenosine | Rattus norvegicus (Norway rat) | Ki | 0.0095 | 2 | 5 |
| pd 168,077 | Rattus norvegicus (Norway rat) | Ki | 0.1770 | 1 | 1 |
| cyclo(d-tyrosyl-arginyl-arginyl-3-(2-naphthyl)alanyl-glycyl) | Rattus norvegicus (Norway rat) | IC50 | 0.1260 | 1 | 1 |
| psb 1115 | Rattus norvegicus (Norway rat) | Ki | 3.1400 | 1 | 1 |
| n-(1-methyl-2-phenylethyl)adenosine, (s)-isomer | Rattus norvegicus (Norway rat) | Ki | 14.9586 | 6 | 7 |
| fk 453 | Rattus norvegicus (Norway rat) | IC50 | 8.1000 | 1 | 1 |
| kf 17837 | Rattus norvegicus (Norway rat) | IC50 | 10.0000 | 1 | 1 |
| kf 17837 | Rattus norvegicus (Norway rat) | Ki | 0.0061 | 3 | 4 |
| dihydrexidine | Rattus norvegicus (Norway rat) | Ki | 3.0000 | 1 | 1 |
| mrs 1754 | Rattus norvegicus (Norway rat) | Ki | 0.0128 | 3 | 3 |
| cv 1808 | Rattus norvegicus (Norway rat) | IC50 | 0.1450 | 1 | 2 |
| cv 1808 | Rattus norvegicus (Norway rat) | Ki | 0.0962 | 3 | 5 |
| n(6)-cyclohexyladenosine | Rattus norvegicus (Norway rat) | IC50 | 0.5880 | 4 | 9 |
| n(6)-cyclohexyladenosine | Rattus norvegicus (Norway rat) | Ki | 6.2686 | 4 | 5 |
| 3-iodo-4-aminobenzyl-5'-N-methylcarboxamidoadenosine | Rattus norvegicus (Norway rat) | Ki | 0.1970 | 1 | 2 |
| n(6)-(2,2-diphenylethyl)adenosine | Rattus norvegicus (Norway rat) | Ki | 0.0250 | 2 | 2 |
| cgs 24012 | Rattus norvegicus (Norway rat) | Ki | 0.0051 | 4 | 9 |
| n-cyclopropyl adenosine-5'-carboxamide | Rattus norvegicus (Norway rat) | Ki | 0.0108 | 2 | 3 |
Drugs with Activation Measurements
Drugs with Other Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| 1,3-dipropyl-8-cyclopentylxanthine | Rattus norvegicus (Norway rat) | Kb | 0.2500 | 1 | 1 |
| 1,3-dipropyl-8-cyclopentylxanthine | Rattus norvegicus (Norway rat) | Ratio | 0.3400 | 1 | 2 |
| 8-(4-sulfophenyl)theophylline | Rattus norvegicus (Norway rat) | Ratio | 1.5000 | 1 | 2 |
| 8-cyclopentyl-1,3-dimethylxanthine | Rattus norvegicus (Norway rat) | Ratio | 1.4000 | 1 | 2 |
| 8-phenyltheophylline | Rattus norvegicus (Norway rat) | Ratio | 0.8500 | 1 | 2 |
| theophylline | Rattus norvegicus (Norway rat) | Ratio | 25.0000 | 1 | 2 |
| caffeine | Rattus norvegicus (Norway rat) | Ratio | 48.0000 | 1 | 2 |
| cgs 15943 | Rattus norvegicus (Norway rat) | Ratio | 0.0033 | 1 | 2 |
| 8-(4-((2-aminoethyl)aminocarbonylmethyloxy)phenyl)-1,3-dipropylxanthine | Rattus norvegicus (Norway rat) | Ratio | 0.0600 | 1 | 2 |
| 2-chloroadenosine | Rattus norvegicus (Norway rat) | EC25 | 0.0130 | 1 | 1 |
| 2-chloroadenosine | Rattus norvegicus (Norway rat) | Ratio | 0.0630 | 1 | 2 |
| rolofylline | Rattus norvegicus (Norway rat) | Ratio | 0.3800 | 1 | 2 |
| n(6)-benzyladenosine | Rattus norvegicus (Norway rat) | EC25 | 0.0350 | 1 | 1 |
| 1,3-dipropyl-8-(2-amino-4-chlorophenyl)xanthine | Rattus norvegicus (Norway rat) | Ratio | 0.0920 | 1 | 2 |
| phenylisopropyladenosine | Rattus norvegicus (Norway rat) | EC25 | 0.0100 | 1 | 1 |
| phenylisopropyladenosine | Rattus norvegicus (Norway rat) | Ratio | 0.1240 | 1 | 2 |
| 3,7-dimethyl-1-propargylxanthine | Rattus norvegicus (Norway rat) | Ratio | 9.6000 | 1 | 2 |
| n(6)-phenyladenosine | Rattus norvegicus (Norway rat) | Ratio | 0.6630 | 1 | 2 |
| bw a1433u | Rattus norvegicus (Norway rat) | Kb | 0.6400 | 1 | 1 |
| 2-chloro-n(6)cyclopentyladenosine | Rattus norvegicus (Norway rat) | Ratio | 0.9500 | 1 | 2 |
| cp 66713 | Rattus norvegicus (Norway rat) | Ratio | 0.0210 | 1 | 2 |
| adenosine amine congener | Rattus norvegicus (Norway rat) | Ratio | 0.2100 | 1 | 2 |
| 8-(4-carboxymethyloxy)phenyl-1,3-dipropylxanthine | Rattus norvegicus (Norway rat) | Ratio | 2.2000 | 1 | 2 |
| 1,3-dipropyl-8-phenylxanthine | Rattus norvegicus (Norway rat) | Kb | 2.3000 | 1 | 1 |
| 8-(dicyclopropylmethyl)-1,3-dipropylxanthine | Rattus norvegicus (Norway rat) | Ratio | 0.4300 | 1 | 2 |
| kfm 19 | Rattus norvegicus (Norway rat) | Ratio | 1.5100 | 1 | 2 |
| 2-(1-octynyl)adenosine | Rattus norvegicus (Norway rat) | Ratio | 0.0120 | 1 | 2 |
| 1,3-dipropylxanthine | Rattus norvegicus (Norway rat) | Kb | 5.4000 | 1 | 1 |
| adenosine-5'-(n-ethylcarboxamide) | Rattus norvegicus (Norway rat) | Ratio | 0.0103 | 1 | 2 |
| n(6)-cyclopentyladenosine | Rattus norvegicus (Norway rat) | EC25 | 0.1000 | 1 | 1 |
| n(6)-cyclopentyladenosine | Rattus norvegicus (Norway rat) | Ratio | 0.4620 | 1 | 2 |
| 2-(4-(2-carboxyethyl)phenethylamino)-5'-n-ethylcarboxamidoadenosine | Rattus norvegicus (Norway rat) | Ratio | 0.0150 | 1 | 2 |
| cv 1808 | Rattus norvegicus (Norway rat) | EC25 | 0.0030 | 1 | 1 |
| cv 1808 | Rattus norvegicus (Norway rat) | Ratio | 0.1190 | 1 | 2 |
| n(6)-cyclohexyladenosine | Rattus norvegicus (Norway rat) | Ratio | 0.5140 | 1 | 2 |
| n(6)-(2,2-diphenylethyl)adenosine | Rattus norvegicus (Norway rat) | EC25 | 0.0100 | 1 | 1 |
| n(6)-(2,2-diphenylethyl)adenosine | Rattus norvegicus (Norway rat) | Ratio | 0.0250 | 1 | 2 |
| cgs 24012 | Rattus norvegicus (Norway rat) | Ratio | 0.0044 | 1 | 2 |
Structure-activity relationships at human and rat A2B adenosine receptors of xanthine derivatives substituted at the 1-, 3-, 7-, and 8-positions.Journal of medicinal chemistry, , May-23, Volume: 45, Issue:11, 2002
Synthesis and biological evaluation of the enantiomers of the potent and selective A1-adenosine antagonist 1,3-dipropyl-8-[2-(5,6-epoxynorbonyl)]-xanthine.Journal of medicinal chemistry, , Jun-06, Volume: 40, Issue:12, 1997
Adenosine A1 antagonists. 3. Structure-activity relationships on amelioration against scopolamine- or N6-((R)-phenylisopropyl)adenosine-induced cognitive disturbance.Journal of medicinal chemistry, , Aug-20, Volume: 36, Issue:17, 1993
8-Polycycloalkyl-1,3-dipropylxanthines as potent and selective antagonists for A1-adenosine receptors.Journal of medicinal chemistry, , Mar-06, Volume: 35, Issue:5, 1992
(E)-1,3-dialkyl-7-methyl-8-(3,4,5-trimethoxystyryl)xanthines: potent and selective adenosine A2 antagonists.Journal of medicinal chemistry, , Jun-12, Volume: 35, Issue:12, 1992
Adenosine receptors: pharmacology, structure-activity relationships, and therapeutic potential.Journal of medicinal chemistry, , Feb-07, Volume: 35, Issue:3, 1992
8-(Dicyclopropylmethyl)-1,3-dipropylxanthine: a potent and selective adenosine A1 antagonist with renal protective and diuretic activities.Journal of medicinal chemistry, , Volume: 34, Issue:1, 1991
Structure-activity relationships of 8-cycloalkyl-1,3-dipropylxanthines as antagonists of adenosine receptors.Journal of medicinal chemistry, , Volume: 33, Issue:7, 1990
Sulfur-containing 1,3-dialkylxanthine derivatives as selective antagonists at A1-adenosine receptors.Journal of medicinal chemistry, , Volume: 32, Issue:8, 1989
Effects of 8-phenyl and 8-cycloalkyl substituents on the activity of mono-, di-, and trisubstituted alkylxanthines with substitution at the 1-, 3-, and 7-positions.Journal of medicinal chemistry, , Volume: 32, Issue:6, 1989
8-Aryl-and 8-cycloalkyl-1,3-dipropylxanthines: further potent and selective antagonists for A1-adenosine receptors.Journal of medicinal chemistry, , Volume: 31, Issue:3, 1988
Effects of 8-phenyl and 8-cycloalkyl substituents on the activity of mono-, di-, and trisubstituted alkylxanthines with substitution at the 1-, 3-, and 7-positions.Journal of medicinal chemistry, , Volume: 32, Issue:6, 1989
Analogues of 1,3-dipropyl-8-phenylxanthine: enhancement of selectivity at A1-adenosine receptors by aryl substituents.Journal of medicinal chemistry, , Volume: 29, Issue:8, 1986
Imidazodiazepinediones: a new class of adenosine receptor antagonists.Journal of medicinal chemistry, , Volume: 33, Issue:10, 1990
Effects of 8-phenyl and 8-cycloalkyl substituents on the activity of mono-, di-, and trisubstituted alkylxanthines with substitution at the 1-, 3-, and 7-positions.Journal of medicinal chemistry, , Volume: 32, Issue:6, 1989
Adenosine receptors: pharmacology, structure-activity relationships, and therapeutic potential.Journal of medicinal chemistry, , Feb-07, Volume: 35, Issue:3, 1992
Effects of 8-phenyl and 8-cycloalkyl substituents on the activity of mono-, di-, and trisubstituted alkylxanthines with substitution at the 1-, 3-, and 7-positions.Journal of medicinal chemistry, , Volume: 32, Issue:6, 1989
Adenosine receptors: pharmacology, structure-activity relationships, and therapeutic potential.Journal of medicinal chemistry, , Feb-07, Volume: 35, Issue:3, 1992
Sulfur-containing 1,3-dialkylxanthine derivatives as selective antagonists at A1-adenosine receptors.Journal of medicinal chemistry, , Volume: 32, Issue:8, 1989
Effects of 8-phenyl and 8-cycloalkyl substituents on the activity of mono-, di-, and trisubstituted alkylxanthines with substitution at the 1-, 3-, and 7-positions.Journal of medicinal chemistry, , Volume: 32, Issue:6, 1989
2-Alkynyl-8-aryl-9-methyladenines as novel adenosine receptor antagonists: their synthesis and structure-activity relationships toward hepatic glucose production induced via agonism of the A(2B) receptor.Journal of medicinal chemistry, , Jan-18, Volume: 44, Issue:2, 2001
Synthesis and structure-activity relationships of deazaxanthines: analogs of potent A1- and A2-adenosine receptor antagonists.Journal of medicinal chemistry, , May-13, Volume: 37, Issue:10, 1994
Adenosine receptors: pharmacology, structure-activity relationships, and therapeutic potential.Journal of medicinal chemistry, , Feb-07, Volume: 35, Issue:3, 1992
Sulfur-containing 1,3-dialkylxanthine derivatives as selective antagonists at A1-adenosine receptors.Journal of medicinal chemistry, , Volume: 32, Issue:8, 1989
Effects of 8-phenyl and 8-cycloalkyl substituents on the activity of mono-, di-, and trisubstituted alkylxanthines with substitution at the 1-, 3-, and 7-positions.Journal of medicinal chemistry, , Volume: 32, Issue:6, 1989
Adenosine receptors: targets for future drugs.Journal of medicinal chemistry, , Volume: 25, Issue:3, 1982
2-Amino-5-benzoyl-4-phenylthiazoles: Development of potent and selective adenosine A1 receptor antagonists.Bioorganic & medicinal chemistry, , Mar-15, Volume: 18, Issue:6, 2010
1-alkyl-8-(piperazine-1-sulfonyl)phenylxanthines: development and characterization of adenosine A2B receptor antagonists and a new radioligand with subnanomolar affinity and subtype specificity.Journal of medicinal chemistry, , Jul-09, Volume: 52, Issue:13, 2009
Structure-activity relationships at human and rat A2B adenosine receptors of xanthine derivatives substituted at the 1-, 3-, 7-, and 8-positions.Journal of medicinal chemistry, , May-23, Volume: 45, Issue:11, 2002
Synthesis and structure-activity relationships of deazaxanthines: analogs of potent A1- and A2-adenosine receptor antagonists.Journal of medicinal chemistry, , May-13, Volume: 37, Issue:10, 1994
Adenosine A1 antagonists. 3. Structure-activity relationships on amelioration against scopolamine- or N6-((R)-phenylisopropyl)adenosine-induced cognitive disturbance.Journal of medicinal chemistry, , Aug-20, Volume: 36, Issue:17, 1993
(E)-1,3-dialkyl-7-methyl-8-(3,4,5-trimethoxystyryl)xanthines: potent and selective adenosine A2 antagonists.Journal of medicinal chemistry, , Jun-12, Volume: 35, Issue:12, 1992
Adenosine receptors: pharmacology, structure-activity relationships, and therapeutic potential.Journal of medicinal chemistry, , Feb-07, Volume: 35, Issue:3, 1992
8-(Dicyclopropylmethyl)-1,3-dipropylxanthine: a potent and selective adenosine A1 antagonist with renal protective and diuretic activities.Journal of medicinal chemistry, , Volume: 34, Issue:1, 1991
Imidazodiazepinediones: a new class of adenosine receptor antagonists.Journal of medicinal chemistry, , Volume: 33, Issue:10, 1990
Sulfur-containing 1,3-dialkylxanthine derivatives as selective antagonists at A1-adenosine receptors.Journal of medicinal chemistry, , Volume: 32, Issue:8, 1989
Effects of 8-phenyl and 8-cycloalkyl substituents on the activity of mono-, di-, and trisubstituted alkylxanthines with substitution at the 1-, 3-, and 7-positions.Journal of medicinal chemistry, , Volume: 32, Issue:6, 1989
Benzo[1,2-c:5,4-c']dipyrazoles: non-xanthine adenosine antagonists.Journal of medicinal chemistry, , Volume: 31, Issue:10, 1988
Adenosine receptors: targets for future drugs.Journal of medicinal chemistry, , Volume: 25, Issue:3, 1982
Fluorescent-Labeled Selective Adenosine AJournal of medicinal chemistry, , 05-24, Volume: 61, Issue:10, 2018
Synthesis and structure-activity relationships of deazaxanthines: analogs of potent A1- and A2-adenosine receptor antagonists.Journal of medicinal chemistry, , May-13, Volume: 37, Issue:10, 1994
Adenosine A1 antagonists. 3. Structure-activity relationships on amelioration against scopolamine- or N6-((R)-phenylisopropyl)adenosine-induced cognitive disturbance.Journal of medicinal chemistry, , Aug-20, Volume: 36, Issue:17, 1993
8-Polycycloalkyl-1,3-dipropylxanthines as potent and selective antagonists for A1-adenosine receptors.Journal of medicinal chemistry, , Mar-06, Volume: 35, Issue:5, 1992
(E)-1,3-dialkyl-7-methyl-8-(3,4,5-trimethoxystyryl)xanthines: potent and selective adenosine A2 antagonists.Journal of medicinal chemistry, , Jun-12, Volume: 35, Issue:12, 1992
Adenosine receptors: pharmacology, structure-activity relationships, and therapeutic potential.Journal of medicinal chemistry, , Feb-07, Volume: 35, Issue:3, 1992
8-(Dicyclopropylmethyl)-1,3-dipropylxanthine: a potent and selective adenosine A1 antagonist with renal protective and diuretic activities.Journal of medicinal chemistry, , Volume: 34, Issue:1, 1991
4-Amino[1,2,4]triazolo[4,3-a]quinoxalines. A novel class of potent adenosine receptor antagonists and potential rapid-onset antidepressants.Journal of medicinal chemistry, , Volume: 33, Issue:8, 1990
Imidazodiazepinediones: a new class of adenosine receptor antagonists.Journal of medicinal chemistry, , Volume: 33, Issue:10, 1990
Effects of 8-phenyl and 8-cycloalkyl substituents on the activity of mono-, di-, and trisubstituted alkylxanthines with substitution at the 1-, 3-, and 7-positions.Journal of medicinal chemistry, , Volume: 32, Issue:6, 1989
Adenosine receptors: targets for future drugs.Journal of medicinal chemistry, , Volume: 25, Issue:3, 1982
Adenosine receptors: pharmacology, structure-activity relationships, and therapeutic potential.Journal of medicinal chemistry, , Feb-07, Volume: 35, Issue:3, 1992
4-Amino[1,2,4]triazolo[4,3-a]quinoxalines. A novel class of potent adenosine receptor antagonists and potential rapid-onset antidepressants.Journal of medicinal chemistry, , Volume: 33, Issue:8, 1990
4-Amino[1,2,4]triazolo[4,3-a]quinoxalines. A novel class of potent adenosine receptor antagonists and potential rapid-onset antidepressants.Journal of medicinal chemistry, , Volume: 33, Issue:8, 1990
Imidazodiazepinediones: a new class of adenosine receptor antagonists.Journal of medicinal chemistry, , Volume: 33, Issue:10, 1990
Adenosine receptors: targets for future drugs.Journal of medicinal chemistry, , Volume: 25, Issue:3, 1982
(E)-1,3-dialkyl-7-methyl-8-(3,4,5-trimethoxystyryl)xanthines: potent and selective adenosine A2 antagonists.Journal of medicinal chemistry, , Jun-12, Volume: 35, Issue:12, 1992
Adenosine receptors: pharmacology, structure-activity relationships, and therapeutic potential.Journal of medicinal chemistry, , Feb-07, Volume: 35, Issue:3, 1992
Sulfur-containing 1,3-dialkylxanthine derivatives as selective antagonists at A1-adenosine receptors.Journal of medicinal chemistry, , Volume: 32, Issue:8, 1989
Adenosine receptors: pharmacology, structure-activity relationships, and therapeutic potential.Journal of medicinal chemistry, , Feb-07, Volume: 35, Issue:3, 1992
Highly selective adenosine A2 receptor agonists in a series of N-alkylated 2-aminoadenosines.Journal of medicinal chemistry, , Volume: 34, Issue:8, 1991
C2,N6-disubstituted adenosines: synthesis and structure-activity relationships.Journal of medicinal chemistry, , Volume: 32, Issue:8, 1989
N6-(arylalkyl)adenosines. Identification of N6-(9-fluorenylmethyl)adenosine as a highly potent agonist for the adenosine A2 receptor.Journal of medicinal chemistry, , Volume: 31, Issue:1, 1988
N6-cycloalkyladenosines. Potent, A1-selective adenosine agonists.Journal of medicinal chemistry, , Volume: 28, Issue:10, 1985
Adenosine receptors: targets for future drugs.Journal of medicinal chemistry, , Volume: 25, Issue:3, 1982
Synthesis and biological evaluation of N4-substituted imidazo- and v-triazolo[4,5-d]pyridazine nucleosides.Journal of medicinal chemistry, , Dec-10, Volume: 36, Issue:25, 1993
4-Amino[1,2,4]triazolo[4,3-a]quinoxalines. A novel class of potent adenosine receptor antagonists and potential rapid-onset antidepressants.Journal of medicinal chemistry, , Volume: 33, Issue:8, 1990
C2,N6-disubstituted adenosines: synthesis and structure-activity relationships.Journal of medicinal chemistry, , Volume: 32, Issue:8, 1989
Synthesis and biological evaluation of the enantiomers of the potent and selective A1-adenosine antagonist 1,3-dipropyl-8-[2-(5,6-epoxynorbonyl)]-xanthine.Journal of medicinal chemistry, , Jun-06, Volume: 40, Issue:12, 1997
8-Polycycloalkyl-1,3-dipropylxanthines as potent and selective antagonists for A1-adenosine receptors.Journal of medicinal chemistry, , Mar-06, Volume: 35, Issue:5, 1992
Adenosine receptors: pharmacology, structure-activity relationships, and therapeutic potential.Journal of medicinal chemistry, , Feb-07, Volume: 35, Issue:3, 1992
Synthesis and structure-activity relationships of deazaxanthines: analogs of potent A1- and A2-adenosine receptor antagonists.Journal of medicinal chemistry, , May-13, Volume: 37, Issue:10, 1994
Effects of 8-phenyl and 8-cycloalkyl substituents on the activity of mono-, di-, and trisubstituted alkylxanthines with substitution at the 1-, 3-, and 7-positions.Journal of medicinal chemistry, , Volume: 32, Issue:6, 1989
Benzo[1,2-c:5,4-c']dipyrazoles: non-xanthine adenosine antagonists.Journal of medicinal chemistry, , Volume: 31, Issue:10, 1988
Adenosine receptors: pharmacology, structure-activity relationships, and therapeutic potential.Journal of medicinal chemistry, , Feb-07, Volume: 35, Issue:3, 1992
Analogues of 1,3-dipropyl-8-phenylxanthine: enhancement of selectivity at A1-adenosine receptors by aryl substituents.Journal of medicinal chemistry, , Volume: 29, Issue:8, 1986
Adenosine receptors: pharmacology, structure-activity relationships, and therapeutic potential.Journal of medicinal chemistry, , Feb-07, Volume: 35, Issue:3, 1992
2-Alkynyl derivatives of adenosine and adenosine-5'-N-ethyluronamide as selective agonists at A2 adenosine receptors.Journal of medicinal chemistry, , Jun-26, Volume: 35, Issue:13, 1992
Highly selective adenosine A2 receptor agonists in a series of N-alkylated 2-aminoadenosines.Journal of medicinal chemistry, , Volume: 34, Issue:8, 1991
Activity of N6-substituted 2-chloroadenosines at A1 and A2 adenosine receptors.Journal of medicinal chemistry, , Volume: 34, Issue:12, 1991
4-Amino[1,2,4]triazolo[4,3-a]quinoxalines. A novel class of potent adenosine receptor antagonists and potential rapid-onset antidepressants.Journal of medicinal chemistry, , Volume: 33, Issue:8, 1990
C2,N6-disubstituted adenosines: synthesis and structure-activity relationships.Journal of medicinal chemistry, , Volume: 32, Issue:8, 1989
N6-(arylalkyl)adenosines. Identification of N6-(9-fluorenylmethyl)adenosine as a highly potent agonist for the adenosine A2 receptor.Journal of medicinal chemistry, , Volume: 31, Issue:1, 1988
Adenosine receptor agonists: synthesis and biological evaluation of 1-deaza analogues of adenosine derivatives.Journal of medicinal chemistry, , Volume: 31, Issue:6, 1988
N6-[2-(3,5-dimethoxyphenyl)-2-(2-methylphenyl)ethyl]adenosine and its uronamide derivatives. Novel adenosine agonists with both high affinity and high selectivity for the adenosine A2 receptor.Journal of medicinal chemistry, , Volume: 31, Issue:7, 1988
N6-cycloalkyladenosines. Potent, A1-selective adenosine agonists.Journal of medicinal chemistry, , Volume: 28, Issue:10, 1985
C4-substituted 1-beta-D-ribofuranosylpyrazolo[3,4-d]pyrimidines as adenosine agonist analogues.Journal of medicinal chemistry, , Volume: 26, Issue:11, 1983
Adenosine receptors: targets for future drugs.Journal of medicinal chemistry, , Volume: 25, Issue:3, 1982
Adenosine receptors: pharmacology, structure-activity relationships, and therapeutic potential.Journal of medicinal chemistry, , Feb-07, Volume: 35, Issue:3, 1992
Activity of N6-substituted 2-chloroadenosines at A1 and A2 adenosine receptors.Journal of medicinal chemistry, , Volume: 34, Issue:12, 1991
4-Amino[1,2,4]triazolo[4,3-a]quinoxalines. A novel class of potent adenosine receptor antagonists and potential rapid-onset antidepressants.Journal of medicinal chemistry, , Volume: 33, Issue:8, 1990
N6-phenyladenosines: pronounced effect of phenyl substituents on affinity for A2 adenosine receptors.Journal of medicinal chemistry, , Volume: 30, Issue:5, 1987
Effects of 8-phenyl and 8-cycloalkyl substituents on the activity of mono-, di-, and trisubstituted alkylxanthines with substitution at the 1-, 3-, and 7-positions.Journal of medicinal chemistry, , Volume: 32, Issue:6, 1989
8-Aryl-and 8-cycloalkyl-1,3-dipropylxanthines: further potent and selective antagonists for A1-adenosine receptors.Journal of medicinal chemistry, , Volume: 31, Issue:3, 1988
Analogues of 1,3-dipropyl-8-phenylxanthine: enhancement of selectivity at A1-adenosine receptors by aryl substituents.Journal of medicinal chemistry, , Volume: 29, Issue:8, 1986
Adenosine receptors: pharmacology, structure-activity relationships, and therapeutic potential.Journal of medicinal chemistry, , Feb-07, Volume: 35, Issue:3, 1992
Activity of N6-substituted 2-chloroadenosines at A1 and A2 adenosine receptors.Journal of medicinal chemistry, , Volume: 34, Issue:12, 1991
Adenosine receptors: pharmacology, structure-activity relationships, and therapeutic potential.Journal of medicinal chemistry, , Feb-07, Volume: 35, Issue:3, 1992
4-Amino[1,2,4]triazolo[4,3-a]quinoxalines. A novel class of potent adenosine receptor antagonists and potential rapid-onset antidepressants.Journal of medicinal chemistry, , Volume: 33, Issue:8, 1990
Adenosine receptors: pharmacology, structure-activity relationships, and therapeutic potential.Journal of medicinal chemistry, , Feb-07, Volume: 35, Issue:3, 1992
Sulfur-containing 1,3-dialkylxanthine derivatives as selective antagonists at A1-adenosine receptors.Journal of medicinal chemistry, , Volume: 32, Issue:8, 1989
Structure-activity relationships at human and rat A2B adenosine receptors of xanthine derivatives substituted at the 1-, 3-, 7-, and 8-positions.Journal of medicinal chemistry, , May-23, Volume: 45, Issue:11, 2002
Synthesis and structure-activity relationships of deazaxanthines: analogs of potent A1- and A2-adenosine receptor antagonists.Journal of medicinal chemistry, , May-13, Volume: 37, Issue:10, 1994
Synthesis and structure-activity relationships of deazaxanthines: analogs of potent A1- and A2-adenosine receptor antagonists.Journal of medicinal chemistry, , May-13, Volume: 37, Issue:10, 1994
Sulfur-containing 1,3-dialkylxanthine derivatives as selective antagonists at A1-adenosine receptors.Journal of medicinal chemistry, , Volume: 32, Issue:8, 1989
Effects of 8-phenyl and 8-cycloalkyl substituents on the activity of mono-, di-, and trisubstituted alkylxanthines with substitution at the 1-, 3-, and 7-positions.Journal of medicinal chemistry, , Volume: 32, Issue:6, 1989
8-Aryl-and 8-cycloalkyl-1,3-dipropylxanthines: further potent and selective antagonists for A1-adenosine receptors.Journal of medicinal chemistry, , Volume: 31, Issue:3, 1988
Analogues of 1,3-dipropyl-8-phenylxanthine: enhancement of selectivity at A1-adenosine receptors by aryl substituents.Journal of medicinal chemistry, , Volume: 29, Issue:8, 1986
Adenosine A1 antagonists. 3. Structure-activity relationships on amelioration against scopolamine- or N6-((R)-phenylisopropyl)adenosine-induced cognitive disturbance.Journal of medicinal chemistry, , Aug-20, Volume: 36, Issue:17, 1993
8-Polycycloalkyl-1,3-dipropylxanthines as potent and selective antagonists for A1-adenosine receptors.Journal of medicinal chemistry, , Mar-06, Volume: 35, Issue:5, 1992
Adenosine receptors: pharmacology, structure-activity relationships, and therapeutic potential.Journal of medicinal chemistry, , Feb-07, Volume: 35, Issue:3, 1992
8-(Dicyclopropylmethyl)-1,3-dipropylxanthine: a potent and selective adenosine A1 antagonist with renal protective and diuretic activities.Journal of medicinal chemistry, , Volume: 34, Issue:1, 1991
Adenosine A1 antagonists. 3. Structure-activity relationships on amelioration against scopolamine- or N6-((R)-phenylisopropyl)adenosine-induced cognitive disturbance.Journal of medicinal chemistry, , Aug-20, Volume: 36, Issue:17, 1993
Adenosine receptors: pharmacology, structure-activity relationships, and therapeutic potential.Journal of medicinal chemistry, , Feb-07, Volume: 35, Issue:3, 1992
Nucleosides and nucleotides. 112. 2-(1-Hexyn-1-yl)adenosine-5'-uronamides: a new entry of selective A2 adenosine receptor agonists with potent antihypertensive activity.Journal of medicinal chemistry, , Jul-24, Volume: 35, Issue:15, 1992
Nucleosides and nucleotides. 107. 2-(cycloalkylalkynyl)adenosines: adenosine A2 receptor agonists with potent antihypertensive effects.Journal of medicinal chemistry, , Jun-12, Volume: 35, Issue:12, 1992
Adenosine receptors: pharmacology, structure-activity relationships, and therapeutic potential.Journal of medicinal chemistry, , Feb-07, Volume: 35, Issue:3, 1992
2-Alkynyl derivatives of adenosine and adenosine-5'-N-ethyluronamide as selective agonists at A2 adenosine receptors.Journal of medicinal chemistry, , Jun-26, Volume: 35, Issue:13, 1992
Synthesis and structure-activity relationships of deazaxanthines: analogs of potent A1- and A2-adenosine receptor antagonists.Journal of medicinal chemistry, , May-13, Volume: 37, Issue:10, 1994
Effects of 8-phenyl and 8-cycloalkyl substituents on the activity of mono-, di-, and trisubstituted alkylxanthines with substitution at the 1-, 3-, and 7-positions.Journal of medicinal chemistry, , Volume: 32, Issue:6, 1989
Nucleosides and nucleotides. 112. 2-(1-Hexyn-1-yl)adenosine-5'-uronamides: a new entry of selective A2 adenosine receptor agonists with potent antihypertensive activity.Journal of medicinal chemistry, , Jul-24, Volume: 35, Issue:15, 1992
2-Alkynyl derivatives of adenosine and adenosine-5'-N-ethyluronamide as selective agonists at A2 adenosine receptors.Journal of medicinal chemistry, , Jun-26, Volume: 35, Issue:13, 1992
Synthesis and structure-activity relationships of deazaxanthines: analogs of potent A1- and A2-adenosine receptor antagonists.Journal of medicinal chemistry, , May-13, Volume: 37, Issue:10, 1994
(E)-1,3-dialkyl-7-methyl-8-(3,4,5-trimethoxystyryl)xanthines: potent and selective adenosine A2 antagonists.Journal of medicinal chemistry, , Jun-12, Volume: 35, Issue:12, 1992
8-(Dicyclopropylmethyl)-1,3-dipropylxanthine: a potent and selective adenosine A1 antagonist with renal protective and diuretic activities.Journal of medicinal chemistry, , Volume: 34, Issue:1, 1991
Sulfur-containing 1,3-dialkylxanthine derivatives as selective antagonists at A1-adenosine receptors.Journal of medicinal chemistry, , Volume: 32, Issue:8, 1989
Effects of 8-phenyl and 8-cycloalkyl substituents on the activity of mono-, di-, and trisubstituted alkylxanthines with substitution at the 1-, 3-, and 7-positions.Journal of medicinal chemistry, , Volume: 32, Issue:6, 1989
Benzo[1,2-c:5,4-c']dipyrazoles: non-xanthine adenosine antagonists.Journal of medicinal chemistry, , Volume: 31, Issue:10, 1988
8-Aryl-and 8-cycloalkyl-1,3-dipropylxanthines: further potent and selective antagonists for A1-adenosine receptors.Journal of medicinal chemistry, , Volume: 31, Issue:3, 1988
Design, synthesis, and biological evaluation of C9- and C2-substituted pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidines as new A2A and A3 adenosine receptors antagonists.Journal of medicinal chemistry, , Mar-27, Volume: 46, Issue:7, 2003
Nucleosides and nucleotides. 177. 9-(6,7-dideoxy-beta-D-allo-hept-5- ynofuranosyl)adenine: a selective and potent ligand for P3 purinoceptor-like protein.Journal of medicinal chemistry, , Jul-16, Volume: 41, Issue:15, 1998
Structure-activity relationships of N6-benzyladenosine-5'-uronamides as A3-selective adenosine agonists.Journal of medicinal chemistry, , Mar-04, Volume: 37, Issue:5, 1994
Nucleosides and nucleotides. 112. 2-(1-Hexyn-1-yl)adenosine-5'-uronamides: a new entry of selective A2 adenosine receptor agonists with potent antihypertensive activity.Journal of medicinal chemistry, , Jul-24, Volume: 35, Issue:15, 1992
Adenosine receptors: pharmacology, structure-activity relationships, and therapeutic potential.Journal of medicinal chemistry, , Feb-07, Volume: 35, Issue:3, 1992
2-Alkynyl derivatives of adenosine and adenosine-5'-N-ethyluronamide as selective agonists at A2 adenosine receptors.Journal of medicinal chemistry, , Jun-26, Volume: 35, Issue:13, 1992
Highly selective adenosine A2 receptor agonists in a series of N-alkylated 2-aminoadenosines.Journal of medicinal chemistry, , Volume: 34, Issue:8, 1991
4-Amino[1,2,4]triazolo[4,3-a]quinoxalines. A novel class of potent adenosine receptor antagonists and potential rapid-onset antidepressants.Journal of medicinal chemistry, , Volume: 33, Issue:8, 1990
Adenosine receptor agonists: synthesis and biological evaluation of 1-deaza analogues of adenosine derivatives.Journal of medicinal chemistry, , Volume: 31, Issue:6, 1988
N6-[2-(3,5-dimethoxyphenyl)-2-(2-methylphenyl)ethyl]adenosine and its uronamide derivatives. Novel adenosine agonists with both high affinity and high selectivity for the adenosine A2 receptor.Journal of medicinal chemistry, , Volume: 31, Issue:7, 1988
N6-phenyladenosines: pronounced effect of phenyl substituents on affinity for A2 adenosine receptors.Journal of medicinal chemistry, , Volume: 30, Issue:5, 1987
N6-substituted N-alkyladenosine-5'-uronamides: bifunctional ligands having recognition groups for A1 and A2 adenosine receptors.Journal of medicinal chemistry, , Volume: 29, Issue:9, 1986
N6-cycloalkyladenosines. Potent, A1-selective adenosine agonists.Journal of medicinal chemistry, , Volume: 28, Issue:10, 1985
N6,C8-distributed adenosine derivatives as partial agonists for adenosine A1 receptors.Journal of medicinal chemistry, , Mar-29, Volume: 39, Issue:7, 1996
Adenosine receptors: pharmacology, structure-activity relationships, and therapeutic potential.Journal of medicinal chemistry, , Feb-07, Volume: 35, Issue:3, 1992
2-Alkynyl derivatives of adenosine and adenosine-5'-N-ethyluronamide as selective agonists at A2 adenosine receptors.Journal of medicinal chemistry, , Jun-26, Volume: 35, Issue:13, 1992
Highly selective adenosine A2 receptor agonists in a series of N-alkylated 2-aminoadenosines.Journal of medicinal chemistry, , Volume: 34, Issue:8, 1991
Activity of N6-substituted 2-chloroadenosines at A1 and A2 adenosine receptors.Journal of medicinal chemistry, , Volume: 34, Issue:12, 1991
C2,N6-disubstituted adenosines: synthesis and structure-activity relationships.Journal of medicinal chemistry, , Volume: 32, Issue:8, 1989
N6-(arylalkyl)adenosines. Identification of N6-(9-fluorenylmethyl)adenosine as a highly potent agonist for the adenosine A2 receptor.Journal of medicinal chemistry, , Volume: 31, Issue:1, 1988
Adenosine receptor agonists: synthesis and biological evaluation of 1-deaza analogues of adenosine derivatives.Journal of medicinal chemistry, , Volume: 31, Issue:6, 1988
N6-[2-(3,5-dimethoxyphenyl)-2-(2-methylphenyl)ethyl]adenosine and its uronamide derivatives. Novel adenosine agonists with both high affinity and high selectivity for the adenosine A2 receptor.Journal of medicinal chemistry, , Volume: 31, Issue:7, 1988
N6-cycloalkyladenosines. Potent, A1-selective adenosine agonists.Journal of medicinal chemistry, , Volume: 28, Issue:10, 1985
Nucleosides and nucleotides. 112. 2-(1-Hexyn-1-yl)adenosine-5'-uronamides: a new entry of selective A2 adenosine receptor agonists with potent antihypertensive activity.Journal of medicinal chemistry, , Jul-24, Volume: 35, Issue:15, 1992
Nucleosides and nucleotides. 107. 2-(cycloalkylalkynyl)adenosines: adenosine A2 receptor agonists with potent antihypertensive effects.Journal of medicinal chemistry, , Jun-12, Volume: 35, Issue:12, 1992
Adenosine receptors: pharmacology, structure-activity relationships, and therapeutic potential.Journal of medicinal chemistry, , Feb-07, Volume: 35, Issue:3, 1992
AJournal of medicinal chemistry, , 04-25, Volume: 62, Issue:8, 2019
4-Amino[1,2,4]triazolo[4,3-a]quinoxalines. A novel class of potent adenosine receptor antagonists and potential rapid-onset antidepressants.Journal of medicinal chemistry, , Volume: 33, Issue:8, 1990
N6-cycloalkyladenosines. Potent, A1-selective adenosine agonists.Journal of medicinal chemistry, , Volume: 28, Issue:10, 1985
Adenosine receptors: targets for future drugs.Journal of medicinal chemistry, , Volume: 25, Issue:3, 1982
2-Alkynyl-8-aryl-9-methyladenines as novel adenosine receptor antagonists: their synthesis and structure-activity relationships toward hepatic glucose production induced via agonism of the A(2B) receptor.Journal of medicinal chemistry, , Jan-18, Volume: 44, Issue:2, 2001
Adenosine A1 antagonists. 3. Structure-activity relationships on amelioration against scopolamine- or N6-((R)-phenylisopropyl)adenosine-induced cognitive disturbance.Journal of medicinal chemistry, , Aug-20, Volume: 36, Issue:17, 1993
Photoisomerization of a potent and selective adenosine A2 antagonist, (E)-1,3-Dipropyl-8-(3,4-dimethoxystyryl)-7-methylxanthine.Journal of medicinal chemistry, , Nov-12, Volume: 36, Issue:23, 1993
(E)-1,3-dialkyl-7-methyl-8-(3,4,5-trimethoxystyryl)xanthines: potent and selective adenosine A2 antagonists.Journal of medicinal chemistry, , Jun-12, Volume: 35, Issue:12, 1992
(5aR,11bS)-4,5,5a,6,7,11b-hexahydro-2-propyl-3-thia-5-azacyclopent-1- ena[c]-phenanthrene-9,10-diol (A-86929): a potent and selective dopamine D1 agonist that maintains behavioral efficacy following repeated administration and characterization of its diacJournal of medicinal chemistry, , Sep-01, Volume: 38, Issue:18, 1995
AJournal of medicinal chemistry, , 04-25, Volume: 62, Issue:8, 2019
1-alkyl-8-(piperazine-1-sulfonyl)phenylxanthines: development and characterization of adenosine A2B receptor antagonists and a new radioligand with subnanomolar affinity and subtype specificity.Journal of medicinal chemistry, , Jul-09, Volume: 52, Issue:13, 2009
Structure-activity relationships at human and rat A2B adenosine receptors of xanthine derivatives substituted at the 1-, 3-, 7-, and 8-positions.Journal of medicinal chemistry, , May-23, Volume: 45, Issue:11, 2002
Nucleosides and nucleotides. 112. 2-(1-Hexyn-1-yl)adenosine-5'-uronamides: a new entry of selective A2 adenosine receptor agonists with potent antihypertensive activity.Journal of medicinal chemistry, , Jul-24, Volume: 35, Issue:15, 1992
Adenosine receptors: pharmacology, structure-activity relationships, and therapeutic potential.Journal of medicinal chemistry, , Feb-07, Volume: 35, Issue:3, 1992
Highly selective adenosine A2 receptor agonists in a series of N-alkylated 2-aminoadenosines.Journal of medicinal chemistry, , Volume: 34, Issue:8, 1991
C2,N6-disubstituted adenosines: synthesis and structure-activity relationships.Journal of medicinal chemistry, , Volume: 32, Issue:8, 1989
N6-(arylalkyl)adenosines. Identification of N6-(9-fluorenylmethyl)adenosine as a highly potent agonist for the adenosine A2 receptor.Journal of medicinal chemistry, , Volume: 31, Issue:1, 1988
N6-[2-(3,5-dimethoxyphenyl)-2-(2-methylphenyl)ethyl]adenosine and its uronamide derivatives. Novel adenosine agonists with both high affinity and high selectivity for the adenosine A2 receptor.Journal of medicinal chemistry, , Volume: 31, Issue:7, 1988
Adenosine receptors: pharmacology, structure-activity relationships, and therapeutic potential.Journal of medicinal chemistry, , Feb-07, Volume: 35, Issue:3, 1992
Highly selective adenosine A2 receptor agonists in a series of N-alkylated 2-aminoadenosines.Journal of medicinal chemistry, , Volume: 34, Issue:8, 1991
4-Amino[1,2,4]triazolo[4,3-a]quinoxalines. A novel class of potent adenosine receptor antagonists and potential rapid-onset antidepressants.Journal of medicinal chemistry, , Volume: 33, Issue:8, 1990
C2,N6-disubstituted adenosines: synthesis and structure-activity relationships.Journal of medicinal chemistry, , Volume: 32, Issue:8, 1989
N6-phenyladenosines: pronounced effect of phenyl substituents on affinity for A2 adenosine receptors.Journal of medicinal chemistry, , Volume: 30, Issue:5, 1987
N6-cycloalkyladenosines. Potent, A1-selective adenosine agonists.Journal of medicinal chemistry, , Volume: 28, Issue:10, 1985
C4-substituted 1-beta-D-ribofuranosylpyrazolo[3,4-d]pyrimidines as adenosine agonist analogues.Journal of medicinal chemistry, , Volume: 26, Issue:11, 1983
Adenosine receptors: targets for future drugs.Journal of medicinal chemistry, , Volume: 25, Issue:3, 1982
Adenosine receptors: pharmacology, structure-activity relationships, and therapeutic potential.Journal of medicinal chemistry, , Feb-07, Volume: 35, Issue:3, 1992
C2,N6-disubstituted adenosines: synthesis and structure-activity relationships.Journal of medicinal chemistry, , Volume: 32, Issue:8, 1989
N6-(arylalkyl)adenosines. Identification of N6-(9-fluorenylmethyl)adenosine as a highly potent agonist for the adenosine A2 receptor.Journal of medicinal chemistry, , Volume: 31, Issue:1, 1988
N6-[2-(3,5-dimethoxyphenyl)-2-(2-methylphenyl)ethyl]adenosine and its uronamide derivatives. Novel adenosine agonists with both high affinity and high selectivity for the adenosine A2 receptor.Journal of medicinal chemistry, , Volume: 31, Issue:7, 1988
Nucleosides and nucleotides. 112. 2-(1-Hexyn-1-yl)adenosine-5'-uronamides: a new entry of selective A2 adenosine receptor agonists with potent antihypertensive activity.Journal of medicinal chemistry, , Jul-24, Volume: 35, Issue:15, 1992
Nucleosides and nucleotides. 107. 2-(cycloalkylalkynyl)adenosines: adenosine A2 receptor agonists with potent antihypertensive effects.Journal of medicinal chemistry, , Jun-12, Volume: 35, Issue:12, 1992
Adenosine receptors: pharmacology, structure-activity relationships, and therapeutic potential.Journal of medicinal chemistry, , Feb-07, Volume: 35, Issue:3, 1992
C2,N6-disubstituted adenosines: synthesis and structure-activity relationships.Journal of medicinal chemistry, , Volume: 32, Issue:8, 1989
N6-[2-(3,5-dimethoxyphenyl)-2-(2-methylphenyl)ethyl]adenosine and its uronamide derivatives. Novel adenosine agonists with both high affinity and high selectivity for the adenosine A2 receptor.Journal of medicinal chemistry, , Volume: 31, Issue:7, 1988
Structure-activity relationships of N6-benzyladenosine-5'-uronamides as A3-selective adenosine agonists.Journal of medicinal chemistry, , Mar-04, Volume: 37, Issue:5, 1994
N6-substituted N-alkyladenosine-5'-uronamides: bifunctional ligands having recognition groups for A1 and A2 adenosine receptors.Journal of medicinal chemistry, , Volume: 29, Issue:9, 1986
Adenosine receptors: targets for future drugs.Journal of medicinal chemistry, , Volume: 25, Issue:3, 1982