Page last updated: 2024-08-07 15:12:01
Beta-1 adrenergic receptor
[no definition available]
Synonyms
Research
Bioassay Publications (27)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 19 (70.37) | 18.7374 |
| 1990's | 6 (22.22) | 18.2507 |
| 2000's | 2 (7.41) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Compounds (28)
Drugs with Inhibition Measurements
Drugs with Activation Measurements
Drugs with Other Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| isoproterenol | Cavia porcellus (domestic guinea pig) | ED25 | 0.0034 | 1 | 1 |
| propranolol | Cavia porcellus (domestic guinea pig) | Affinity constant | 0.0130 | 1 | 1 |
| isoproterenol hydrochloride | Cavia porcellus (domestic guinea pig) | ED25 | 0.0034 | 1 | 1 |
| colterol | Cavia porcellus (domestic guinea pig) | ED25 | 0.0071 | 1 | 1 |
Synthesis and structure-activity relationships of long-acting beta2 adrenergic receptor agonists incorporating arylsulfonamide groups.Journal of medicinal chemistry, , Apr-23, Volume: 52, Issue:8, 2009
Effect of fluorine substitution on the adrenergic properties of 3-(tert-butylamino)-1-(3,4-dihydroxyphenoxy)-2-propanol.Journal of medicinal chemistry, , Volume: 34, Issue:3, 1991
Adrenergic agents. 8.1 Synthesis and beta-adrenergic agonist activity of some 3-tert-butylamino-2-(substituted phenyl)-1-propanols.Journal of medicinal chemistry, , Volume: 20, Issue:10, 1977
Synthesis of a series of compounds related to betaxolol, a new beta 1-adrenoceptor antagonist with a pharmacological and pharmacokinetic profile optimized for the treatment of chronic cardiovascular diseases.Journal of medicinal chemistry, , Volume: 30, Issue:6, 1987
Beta 1-selective adrenoceptor antagonists: examples of the 2-[4-[3-(substituted amino)-2-hydroxypropoxy]phenyl]imidazole class. 2.Journal of medicinal chemistry, , Volume: 29, Issue:6, 1986
Use of (S)-(trifloxymethyl)oxirane in the synthesis of a chiral beta-adrenoceptor antagonist, (R)- and (S)-9-[[3-(tert-butylamino)-2-hydroxypropyl]oximino]fluorene.Journal of medicinal chemistry, , Volume: 25, Issue:8, 1982
Computer-aided mapping of the beta-adrenoceptor. 1. Explanation for effect of para substitution on blocking activity at the beta-1-adrenoceptor.Journal of medicinal chemistry, , Dec-11, Volume: 35, Issue:25, 1992
Synthesis of a series of compounds related to betaxolol, a new beta 1-adrenoceptor antagonist with a pharmacological and pharmacokinetic profile optimized for the treatment of chronic cardiovascular diseases.Journal of medicinal chemistry, , Volume: 30, Issue:6, 1987
Role of the (acyloxy)methyl moiety in eliciting the adrenergic beta-blocking activity of 3-(acyloxy)propanolamines.Journal of medicinal chemistry, , Volume: 30, Issue:4, 1987
An interdisciplinary approach to the design of new structures active at the beta-adrenergic receptor. Aliphatic oxime ether derivatives.Journal of medicinal chemistry, , Volume: 28, Issue:2, 1985
Ultra-short-acting beta-adrenergic receptor blocking agents. 2. (Aryloxy)propanolamines containing esters on the aryl function.Journal of medicinal chemistry, , Volume: 25, Issue:12, 1982
2-Benzodioxinylaminoethanols: a new class of beta-adrenergic blocking and antihypertensive agents.Journal of medicinal chemistry, , Volume: 24, Issue:8, 1981
Conformationally restrained analogs of sympathomimetic catecholamines. Synthesis, conformational analysis, and adrenergic activity of isochroman derivatives.Journal of medicinal chemistry, , Oct-15, Volume: 36, Issue:21, 1993
Synthesis of a series of compounds related to betaxolol, a new beta 1-adrenoceptor antagonist with a pharmacological and pharmacokinetic profile optimized for the treatment of chronic cardiovascular diseases.Journal of medicinal chemistry, , Volume: 30, Issue:6, 1987
Beta 1-selective adrenoceptor antagonists: examples of the 2-[4-[3-(substituted amino)-2-hydroxypropoxy]phenyl]imidazole class. 2.Journal of medicinal chemistry, , Volume: 29, Issue:6, 1986
New chiral and isomeric cyclopropyl ketoxime propanolamine derivatives with potent beta-adrenergic blocking properties.Journal of medicinal chemistry, , Volume: 28, Issue:7, 1985
Synthesis and beta-adrenergic blocking activity of new aliphatic and alicyclic oxime ethers.Journal of medicinal chemistry, , Volume: 27, Issue:10, 1984
The 3,4-catechol derivative of propranolol, a minor dihydroxylated metabolite.Journal of medicinal chemistry, , Volume: 27, Issue:7, 1984
beta 1-selective adrenoceptor antagonists. 1. Synthesis and beta-adrenergic blocking activity of a series of binary (aryloxy)propanolamines.Journal of medicinal chemistry, , Volume: 26, Issue:11, 1983
Ultra-short-acting beta-adrenergic receptor blocking agents. 2. (Aryloxy)propanolamines containing esters on the aryl function.Journal of medicinal chemistry, , Volume: 25, Issue:12, 1982
2-Benzodioxinylaminoethanols: a new class of beta-adrenergic blocking and antihypertensive agents.Journal of medicinal chemistry, , Volume: 24, Issue:8, 1981
Synthesis and beta-adrenergic blocking activity of new aliphatic oxime ethers.Journal of medicinal chemistry, , Volume: 23, Issue:6, 1980
Adrenoceptor blocking agents. 2. 2-(alpha-Hydroxyarylmethyl)-3,3-dimethylaziridines, a new class of selective beta2-adrenoceptor antagonists.Journal of medicinal chemistry, , Volume: 21, Issue:1, 1978