Page last updated: 2024-08-07 21:16:05
Carbonic anhydrase
A protein that is a translation product of the NCE103 gene in Candida albicans SC5314. [PRO:DAN, UniProtKB:Q5AJ71]
Synonyms
EC 4.2.1.1;
Carbonate dehydratase;
Non-classical export protein 103
Research
Bioassay Publications (11)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 5 (45.45) | 29.6817 |
| 2010's | 6 (54.55) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Compounds (63)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| 4-hydroxyphenylacetic acid | Candida albicans SC5314 | Ki | 1.0200 | 1 | 1 |
| phenol | Candida albicans SC5314 | Ki | 17.3000 | 1 | 1 |
| acetazolamide | Candida albicans SC5314 | Ki | 0.1183 | 8 | 9 |
| celecoxib | Candida albicans SC5314 | Ki | 1.5267 | 3 | 4 |
| dichlorphenamide | Candida albicans SC5314 | Ki | 0.9680 | 4 | 5 |
| ethoxzolamide | Candida albicans SC5314 | Ki | 0.9062 | 5 | 6 |
| mafenide | Candida albicans SC5314 | Ki | 5.4542 | 3 | 4 |
| methazolamide | Candida albicans SC5314 | Ki | 0.3787 | 3 | 4 |
| saccharin | Candida albicans SC5314 | Ki | 11.1573 | 2 | 3 |
| sulfanilamide | Candida albicans SC5314 | Ki | 6.2552 | 4 | 5 |
| sulpiride | Candida albicans SC5314 | Ki | 0.7600 | 2 | 2 |
| sulthiame | Candida albicans SC5314 | Ki | 1.0107 | 2 | 3 |
| zonisamide | Candida albicans SC5314 | Ki | 0.9474 | 4 | 5 |
| sulfamic acid | Candida albicans SC5314 | Ki | 700.0000 | 1 | 1 |
| sodium citrate, anhydrous | Candida albicans SC5314 | Ki | 39.1000 | 1 | 1 |
| 4-toluenesulfonamide | Candida albicans SC5314 | Ki | 1.1905 | 3 | 4 |
| benzenearsonic acid | Candida albicans SC5314 | Ki | 30,840.0000 | 1 | 1 |
| benzenesulfonamide | Candida albicans SC5314 | Ki | 2.3600 | 1 | 1 |
| carzenide | Candida albicans SC5314 | Ki | 0.7668 | 3 | 4 |
| 4-hydroxyphenylethanol | Candida albicans SC5314 | Ki | 1.1000 | 1 | 1 |
| benzolamide | Candida albicans SC5314 | Ki | 1.1382 | 3 | 4 |
| phenylethane boronic acid | Candida albicans SC5314 | Ki | 412.0000 | 1 | 1 |
| benzeneboronic acid | Candida albicans SC5314 | Ki | 30,850.0000 | 2 | 2 |
| 4-amino-6-chloro-1,3-benzenedisulfonamide | Candida albicans SC5314 | Ki | 0.7305 | 3 | 4 |
| brinzolamide | Candida albicans SC5314 | Ki | 0.8430 | 3 | 4 |
| 2,4-disulfamyl-5-trifluoromethylaniline | Candida albicans SC5314 | Ki | 4.8283 | 3 | 4 |
| 4-bromobenzenesulfonamide | Candida albicans SC5314 | Ki | 0.8940 | 1 | 1 |
| 2-aminobenzenesulfonamide | Candida albicans SC5314 | Ki | 0.9093 | 3 | 4 |
| 4-bromophenylboric acid | Candida albicans SC5314 | Ki | 15.9000 | 1 | 1 |
| sulfamide | Candida albicans SC5314 | Ki | 300.0000 | 1 | 1 |
| 5-amino-1,3,4-thiadiazole-2-sulfonamide | Candida albicans SC5314 | Ki | 0.8218 | 3 | 4 |
| 4-(hydroxyphenyl)acetamide | Candida albicans SC5314 | Ki | 0.9100 | 1 | 1 |
| 3-chloro-4-hydroxyphenylacetic acid | Candida albicans SC5314 | Ki | 1.0800 | 1 | 1 |
| valdecoxib | Candida albicans SC5314 | Ki | 0.7002 | 3 | 4 |
| 1,1'-biphenyl-4-yl-boronic acid | Candida albicans SC5314 | Ki | 7.8000 | 1 | 1 |
| chlorzolamide | Candida albicans SC5314 | Ki | 1.0645 | 3 | 4 |
| 4-(2-aminoethyl)benzenesulfonamide | Candida albicans SC5314 | Ki | 2.7447 | 3 | 4 |
| 4-methoxyphenylboronic acid | Candida albicans SC5314 | Ki | 15.6000 | 1 | 1 |
| n-(3-chloro-7-indolyl)-1,4-benzenedisulphonamide | Candida albicans SC5314 | Ki | 1.0582 | 3 | 4 |
| sodium acetate, anhydrous | Candida albicans SC5314 | Ki | 36.0000 | 1 | 1 |
| sodium benzoate | Candida albicans SC5314 | Ki | 24.4000 | 1 | 1 |
| formic acid, sodium salt | Candida albicans SC5314 | Ki | 35.1000 | 1 | 1 |
| sodium propionate | Candida albicans SC5314 | Ki | 51.5000 | 1 | 1 |
| sodium butyrate | Candida albicans SC5314 | Ki | 26.9000 | 1 | 1 |
| dorzolamide | Candida albicans SC5314 | Ki | 2.7520 | 3 | 4 |
| topiramate | Candida albicans SC5314 | Ki | 0.9602 | 4 | 5 |
| endiandrin a | Candida albicans SC5314 | Ki | 0.7300 | 1 | 1 |
Drugs with Other Measurements
Isatin analogs as novel inhibitors of Candida spp. β-carbonic anhydrase enzymes.Bioorganic & medicinal chemistry, , Apr-15, Volume: 24, Issue:8, 2016
Molecular cloning, characterization, and inhibition studies of a β-carbonic anhydrase from Malassezia globosa, a potential antidandruff target.Journal of medicinal chemistry, , Apr-12, Volume: 55, Issue:7, 2012
Synthesis of rhodamine B-benzenesulfonamide conjugates and their inhibitory activity against human α- and bacterial/fungal β-carbonic anhydrases.Bioorganic & medicinal chemistry letters, , Sep-15, Volume: 21, Issue:18, 2011
Natural product-based phenols as novel probes for mycobacterial and fungal carbonic anhydrases.Journal of medicinal chemistry, , Mar-24, Volume: 54, Issue:6, 2011
Carbonic anhydrase inhibitors. The beta-carbonic anhydrases from the fungal pathogens Cryptococcus neoformans and Candida albicans are strongly inhibited by substituted-phenyl-1H-indole-5-sulfonamides.Bioorganic & medicinal chemistry letters, , Apr-15, Volume: 20, Issue:8, 2010
Carbonic anhydrase inhibitors. Inhibition and homology modeling studies of the fungal beta-carbonic anhydrase from Candida albicans with sulfonamides.Bioorganic & medicinal chemistry, , Jul-01, Volume: 17, Issue:13, 2009
Carbonic anhydrase inhibitors. Inhibition of the fungal beta-carbonic anhydrases from Candida albicans and Cryptococcus neoformans with boronic acids.Bioorganic & medicinal chemistry letters, , May-15, Volume: 19, Issue:10, 2009
Carbonic anhydrase inhibitors: inhibition of the beta-class enzymes from the fungal pathogens Candida albicans and Cryptococcus neoformans with simple anions.Bioorganic & medicinal chemistry letters, , Sep-15, Volume: 18, Issue:18, 2008
Molecular cloning, characterization, and inhibition studies of a β-carbonic anhydrase from Malassezia globosa, a potential antidandruff target.Journal of medicinal chemistry, , Apr-12, Volume: 55, Issue:7, 2012
Carbonic anhydrase inhibitors. Inhibition and homology modeling studies of the fungal beta-carbonic anhydrase from Candida albicans with sulfonamides.Bioorganic & medicinal chemistry, , Jul-01, Volume: 17, Issue:13, 2009
Molecular cloning, characterization, and inhibition studies of a β-carbonic anhydrase from Malassezia globosa, a potential antidandruff target.Journal of medicinal chemistry, , Apr-12, Volume: 55, Issue:7, 2012
Carbonic anhydrase inhibitors. Inhibition and homology modeling studies of the fungal beta-carbonic anhydrase from Candida albicans with sulfonamides.Bioorganic & medicinal chemistry, , Jul-01, Volume: 17, Issue:13, 2009
Carbonic anhydrase inhibitors. Inhibition of the fungal beta-carbonic anhydrases from Candida albicans and Cryptococcus neoformans with boronic acids.Bioorganic & medicinal chemistry letters, , May-15, Volume: 19, Issue:10, 2009
Molecular cloning, characterization, and inhibition studies of a β-carbonic anhydrase from Malassezia globosa, a potential antidandruff target.Journal of medicinal chemistry, , Apr-12, Volume: 55, Issue:7, 2012
Carbonic anhydrase inhibitors. The beta-carbonic anhydrases from the fungal pathogens Cryptococcus neoformans and Candida albicans are strongly inhibited by substituted-phenyl-1H-indole-5-sulfonamides.Bioorganic & medicinal chemistry letters, , Apr-15, Volume: 20, Issue:8, 2010
Carbonic anhydrase inhibitors. Inhibition and homology modeling studies of the fungal beta-carbonic anhydrase from Candida albicans with sulfonamides.Bioorganic & medicinal chemistry, , Jul-01, Volume: 17, Issue:13, 2009
Carbonic anhydrase inhibitors. Inhibition of the fungal beta-carbonic anhydrases from Candida albicans and Cryptococcus neoformans with boronic acids.Bioorganic & medicinal chemistry letters, , May-15, Volume: 19, Issue:10, 2009
Molecular cloning, characterization, and inhibition studies of a β-carbonic anhydrase from Malassezia globosa, a potential antidandruff target.Journal of medicinal chemistry, , Apr-12, Volume: 55, Issue:7, 2012
Carbonic anhydrase inhibitors. Inhibition and homology modeling studies of the fungal beta-carbonic anhydrase from Candida albicans with sulfonamides.Bioorganic & medicinal chemistry, , Jul-01, Volume: 17, Issue:13, 2009
Molecular cloning, characterization, and inhibition studies of a β-carbonic anhydrase from Malassezia globosa, a potential antidandruff target.Journal of medicinal chemistry, , Apr-12, Volume: 55, Issue:7, 2012
Carbonic anhydrase inhibitors. Inhibition and homology modeling studies of the fungal beta-carbonic anhydrase from Candida albicans with sulfonamides.Bioorganic & medicinal chemistry, , Jul-01, Volume: 17, Issue:13, 2009
Molecular cloning, characterization, and inhibition studies of a β-carbonic anhydrase from Malassezia globosa, a potential antidandruff target.Journal of medicinal chemistry, , Apr-12, Volume: 55, Issue:7, 2012
Natural product-based phenols as novel probes for mycobacterial and fungal carbonic anhydrases.Journal of medicinal chemistry, , Mar-24, Volume: 54, Issue:6, 2011
Carbonic anhydrase inhibitors. Inhibition and homology modeling studies of the fungal beta-carbonic anhydrase from Candida albicans with sulfonamides.Bioorganic & medicinal chemistry, , Jul-01, Volume: 17, Issue:13, 2009
Molecular cloning, characterization, and inhibition studies of a β-carbonic anhydrase from Malassezia globosa, a potential antidandruff target.Journal of medicinal chemistry, , Apr-12, Volume: 55, Issue:7, 2012
Carbonic anhydrase inhibitors. Inhibition and homology modeling studies of the fungal beta-carbonic anhydrase from Candida albicans with sulfonamides.Bioorganic & medicinal chemistry, , Jul-01, Volume: 17, Issue:13, 2009
Molecular cloning, characterization, and inhibition studies of a β-carbonic anhydrase from Malassezia globosa, a potential antidandruff target.Journal of medicinal chemistry, , Apr-12, Volume: 55, Issue:7, 2012
Natural product-based phenols as novel probes for mycobacterial and fungal carbonic anhydrases.Journal of medicinal chemistry, , Mar-24, Volume: 54, Issue:6, 2011
Carbonic anhydrase inhibitors. Inhibition and homology modeling studies of the fungal beta-carbonic anhydrase from Candida albicans with sulfonamides.Bioorganic & medicinal chemistry, , Jul-01, Volume: 17, Issue:13, 2009
Molecular cloning, characterization, and inhibition studies of a β-carbonic anhydrase from Malassezia globosa, a potential antidandruff target.Journal of medicinal chemistry, , Apr-12, Volume: 55, Issue:7, 2012
Carbonic anhydrase inhibitors. Inhibition and homology modeling studies of the fungal beta-carbonic anhydrase from Candida albicans with sulfonamides.Bioorganic & medicinal chemistry, , Jul-01, Volume: 17, Issue:13, 2009
Molecular cloning, characterization, and inhibition studies of a β-carbonic anhydrase from Malassezia globosa, a potential antidandruff target.Journal of medicinal chemistry, , Apr-12, Volume: 55, Issue:7, 2012
Carbonic anhydrase inhibitors. Inhibition and homology modeling studies of the fungal beta-carbonic anhydrase from Candida albicans with sulfonamides.Bioorganic & medicinal chemistry, , Jul-01, Volume: 17, Issue:13, 2009
Molecular cloning, characterization, and inhibition studies of a β-carbonic anhydrase from Malassezia globosa, a potential antidandruff target.Journal of medicinal chemistry, , Apr-12, Volume: 55, Issue:7, 2012
Carbonic anhydrase inhibitors. Inhibition and homology modeling studies of the fungal beta-carbonic anhydrase from Candida albicans with sulfonamides.Bioorganic & medicinal chemistry, , Jul-01, Volume: 17, Issue:13, 2009
Carbonic anhydrase inhibitors. Inhibition of the fungal beta-carbonic anhydrases from Candida albicans and Cryptococcus neoformans with boronic acids.Bioorganic & medicinal chemistry letters, , May-15, Volume: 19, Issue:10, 2009
Carbonic anhydrase inhibitors: inhibition of the beta-class enzymes from the fungal pathogens Candida albicans and Cryptococcus neoformans with simple anions.Bioorganic & medicinal chemistry letters, , Sep-15, Volume: 18, Issue:18, 2008
Carbonic anhydrase inhibitors. Inhibition of the beta-class enzyme from the yeast Saccharomyces cerevisiae with anions.Bioorganic & medicinal chemistry letters, , Dec-15, Volume: 18, Issue:24, 2008
Molecular cloning, characterization, and inhibition studies of a β-carbonic anhydrase from Malassezia globosa, a potential antidandruff target.Journal of medicinal chemistry, , Apr-12, Volume: 55, Issue:7, 2012
Carbonic anhydrase inhibitors. Inhibition and homology modeling studies of the fungal beta-carbonic anhydrase from Candida albicans with sulfonamides.Bioorganic & medicinal chemistry, , Jul-01, Volume: 17, Issue:13, 2009
Molecular cloning, characterization, and inhibition studies of a β-carbonic anhydrase from Malassezia globosa, a potential antidandruff target.Journal of medicinal chemistry, , Apr-12, Volume: 55, Issue:7, 2012
Carbonic anhydrase inhibitors. Inhibition and homology modeling studies of the fungal beta-carbonic anhydrase from Candida albicans with sulfonamides.Bioorganic & medicinal chemistry, , Jul-01, Volume: 17, Issue:13, 2009
Molecular cloning, characterization, and inhibition studies of a β-carbonic anhydrase from Malassezia globosa, a potential antidandruff target.Journal of medicinal chemistry, , Apr-12, Volume: 55, Issue:7, 2012
Carbonic anhydrase inhibitors. Inhibition and homology modeling studies of the fungal beta-carbonic anhydrase from Candida albicans with sulfonamides.Bioorganic & medicinal chemistry, , Jul-01, Volume: 17, Issue:13, 2009
Molecular cloning, characterization, and inhibition studies of a β-carbonic anhydrase from Malassezia globosa, a potential antidandruff target.Journal of medicinal chemistry, , Apr-12, Volume: 55, Issue:7, 2012
Carbonic anhydrase inhibitors. Inhibition and homology modeling studies of the fungal beta-carbonic anhydrase from Candida albicans with sulfonamides.Bioorganic & medicinal chemistry, , Jul-01, Volume: 17, Issue:13, 2009
Carbonic anhydrase inhibitors: inhibition of the beta-class enzymes from the fungal pathogens Candida albicans and Cryptococcus neoformans with simple anions.Bioorganic & medicinal chemistry letters, , Sep-15, Volume: 18, Issue:18, 2008
Carbonic anhydrase inhibitors. Inhibition of the beta-class enzyme from the yeast Saccharomyces cerevisiae with anions.Bioorganic & medicinal chemistry letters, , Dec-15, Volume: 18, Issue:24, 2008
Molecular cloning, characterization, and inhibition studies of a β-carbonic anhydrase from Malassezia globosa, a potential antidandruff target.Journal of medicinal chemistry, , Apr-12, Volume: 55, Issue:7, 2012
Carbonic anhydrase inhibitors. Inhibition and homology modeling studies of the fungal beta-carbonic anhydrase from Candida albicans with sulfonamides.Bioorganic & medicinal chemistry, , Jul-01, Volume: 17, Issue:13, 2009
Molecular cloning, characterization, and inhibition studies of a β-carbonic anhydrase from Malassezia globosa, a potential antidandruff target.Journal of medicinal chemistry, , Apr-12, Volume: 55, Issue:7, 2012
Carbonic anhydrase inhibitors. Inhibition and homology modeling studies of the fungal beta-carbonic anhydrase from Candida albicans with sulfonamides.Bioorganic & medicinal chemistry, , Jul-01, Volume: 17, Issue:13, 2009
Molecular cloning, characterization, and inhibition studies of a β-carbonic anhydrase from Malassezia globosa, a potential antidandruff target.Journal of medicinal chemistry, , Apr-12, Volume: 55, Issue:7, 2012
Carbonic anhydrase inhibitors. Inhibition and homology modeling studies of the fungal beta-carbonic anhydrase from Candida albicans with sulfonamides.Bioorganic & medicinal chemistry, , Jul-01, Volume: 17, Issue:13, 2009
Molecular cloning, characterization, and inhibition studies of a β-carbonic anhydrase from Malassezia globosa, a potential antidandruff target.Journal of medicinal chemistry, , Apr-12, Volume: 55, Issue:7, 2012
Carbonic anhydrase inhibitors. Inhibition and homology modeling studies of the fungal beta-carbonic anhydrase from Candida albicans with sulfonamides.Bioorganic & medicinal chemistry, , Jul-01, Volume: 17, Issue:13, 2009
Molecular cloning, characterization, and inhibition studies of a β-carbonic anhydrase from Malassezia globosa, a potential antidandruff target.Journal of medicinal chemistry, , Apr-12, Volume: 55, Issue:7, 2012
Carbonic anhydrase inhibitors. Inhibition and homology modeling studies of the fungal beta-carbonic anhydrase from Candida albicans with sulfonamides.Bioorganic & medicinal chemistry, , Jul-01, Volume: 17, Issue:13, 2009
Molecular cloning, characterization, and inhibition studies of a β-carbonic anhydrase from Malassezia globosa, a potential antidandruff target.Journal of medicinal chemistry, , Apr-12, Volume: 55, Issue:7, 2012
Carbonic anhydrase inhibitors. Inhibition and homology modeling studies of the fungal beta-carbonic anhydrase from Candida albicans with sulfonamides.Bioorganic & medicinal chemistry, , Jul-01, Volume: 17, Issue:13, 2009
Molecular cloning, characterization, and inhibition studies of a β-carbonic anhydrase from Malassezia globosa, a potential antidandruff target.Journal of medicinal chemistry, , Apr-12, Volume: 55, Issue:7, 2012
Natural product-based phenols as novel probes for mycobacterial and fungal carbonic anhydrases.Journal of medicinal chemistry, , Mar-24, Volume: 54, Issue:6, 2011
Carbonic anhydrase inhibitors. Inhibition and homology modeling studies of the fungal beta-carbonic anhydrase from Candida albicans with sulfonamides.Bioorganic & medicinal chemistry, , Jul-01, Volume: 17, Issue:13, 2009