Egl nine homolog 1

An egl nine homolog 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9GZT9]

Synonyms

EC 1.14.11.29;
Hypoxia-inducible factor prolyl hydroxylase 2;
HIF-PH2;
HIF-prolyl hydroxylase 2;
HPH-2;
Prolyl hydroxylase domain-containing protein 2;
PHD2;
SM-20

Research

Bioassay Publications (24)

Timeframe	Studies on this Protein(%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	3 (12.50)	29.6817
2010's	15 (62.50)	24.3611
2020's	6 (25.00)	2.80

Compounds (21)

Drugs with Inhibition Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
succinic acid	Homo sapiens (human)	IC50	3,362.7667	3	3
isocitric acid	Homo sapiens (human)	IC50	10,000.0000	1	1
succinylacetone	Homo sapiens (human)	IC50	59.0000	2	2
2,5-pyridinedicarboxylic acid	Homo sapiens (human)	Ki	300.0000	1	1
2,4-pyridinedicarboxylic acid	Homo sapiens (human)	IC50	5.0333	3	3
2,4-pyridinedicarboxylic acid	Homo sapiens (human)	Ki	7.0000	1	1
daminozide	Homo sapiens (human)	IC50	100.0000	1	1
fumaric acid	Homo sapiens (human)	IC50	119.5000	2	2
5-carboxy-8-hydroxyquinoline	Homo sapiens (human)	IC50	14.6500	2	2
oxalylglycine	Homo sapiens (human)	IC50	14.0500	6	6
oxalylglycine	Homo sapiens (human)	Ki	8.0000	2	2
fg-4592	Homo sapiens (human)	IC50	0.8836	10	10
jnj 42041935	Homo sapiens (human)	IC50	0.1000	1	1
2-[[[4-hydroxy-2-oxo-1-(phenylmethyl)-3-quinolinyl]-oxomethyl]amino]acetic acid	Homo sapiens (human)	IC50	0.0220	2	2
bay 85-3934	Homo sapiens (human)	IC50	0.2901	5	5
gsk1278863	Homo sapiens (human)	IC50	0.0670	1	1

Drugs with Activation Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
alpha-ketoglutaric acid	Homo sapiens (human)	Kd	1.3714	7	7
succinic acid	Homo sapiens (human)	Kd	100.0000	2	2
glycyrrhetinic acid	Homo sapiens (human)	EC50	50.0000	1	1
2,4-pyridinedicarboxylic acid	Homo sapiens (human)	Kd	0.4200	1	1
oleanolic acid	Homo sapiens (human)	EC50	50.0000	1	1
ursolic acid	Homo sapiens (human)	EC50	50.0000	1	1
betulinic acid	Homo sapiens (human)	EC50	50.0000	1	1
maslinic acid	Homo sapiens (human)	EC50	50.0000	1	1
fumaric acid	Homo sapiens (human)	Kd	200.0000	1	1
5-carboxy-8-hydroxyquinoline	Homo sapiens (human)	Kd	60.0000	1	1
oxalylglycine	Homo sapiens (human)	Kd	2.9000	6	6
fg-4592	Homo sapiens (human)	EC50	6.1100	1	1

Drugs with Other Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
alpha-ketoglutaric acid	Homo sapiens (human)	Km	2.0000	1	1
ascorbic acid	Homo sapiens (human)	Km	180.0000	1	1

Enables

This protein enables 8 target(s):

Target	Category	Definition
protein binding	molecular function	Binding to a protein. [GOC:go_curators]
ferrous iron binding	molecular function	Binding to a ferrous iron ion, Fe(II). [GOC:ai]
2-oxoglutarate-dependent dioxygenase activity	molecular function	Catalysis of the reaction: A + 2-oxoglutarate + O2 = B + succinate + CO2. This is an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from 2-oxoglutarate and one other donor, and one atom of oxygen is incorporated into each donor. [GOC:mah]
enzyme binding	molecular function	Binding to an enzyme, a protein with catalytic activity. [GOC:jl]
L-ascorbic acid binding	molecular function	Binding to L-ascorbic acid, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate; L-ascorbic acid is vitamin C and has co-factor and anti-oxidant activities in many species. [GOC:mah]
peptidyl-proline dioxygenase activity	molecular function	Catalysis of the reaction: peptidyl L-proline + 2-oxoglutarate + O2 = peptidyl hydroxy-L-proline + succinate + CO2. [GOC:mah, GOC:vw, PMID:24550447, PMID:24550462]
hypoxia-inducible factor-proline dioxygenase activity	molecular function	Catalysis of the reaction: 2-oxoglutarate + L-prolyl-[hypoxia-inducible factor alpha subunit] + O2 = CO2 + succinate + trans-4-hydroxy-L-prolyl-[hypoxia-inducible factor alpha subunit]. [PMID:11595184, PMID:11598268]
peptidyl-proline 4-dioxygenase activity	molecular function	Catalysis of the reaction: peptidyl L-proline + 2-oxoglutarate + O2 = peptidyl trans-4-hydroxy-L-proline + succinate + CO2. [GOC:mah]

Located In

This protein is located in 5 target(s):

Target	Category	Definition
cytoplasm	cellular component	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684]
cytosol	cellular component	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]
postsynaptic density	cellular component	An electron dense network of proteins within and adjacent to the postsynaptic membrane of an asymmetric, neuron-neuron synapse. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize them such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components. [GOC:BHF, GOC:dos, GOC:ef, GOC:jid, GOC:pr, GOC:sjp, http://molneuro.kaist.ac.kr/psd, PMID:14532281, Wikipedia:Postsynaptic_density]
intracellular membrane-bounded organelle	cellular component	Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane. [GOC:go_curators]
glutamatergic synapse	cellular component	A synapse that uses glutamate as a neurotransmitter. [GOC:dos]

Active In

This protein is active in 2 target(s):

Target	Category	Definition
nucleus	cellular component	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators]
cytoplasm	cellular component	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684]

Involved In

This protein is involved in 16 target(s):

Target	Category	Definition
response to hypoxia	biological process	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level. [GOC:hjd]
intracellular iron ion homeostasis	biological process	A homeostatic process involved in the maintenance of a steady state level of iron ions within a cell. [GOC:ai, GOC:mah]
intracellular oxygen homeostasis	biological process	A homeostatic process involved in the maintenance of a steady state level of oxygen within a cell. [GOC:rph]
negative regulation of DNA-binding transcription factor activity	biological process	Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription. [GOC:jl]
regulation of angiogenesis	biological process	Any process that modulates the frequency, rate or extent of angiogenesis. [GOC:go_curators]
positive regulation of transcription by RNA polymerase II	biological process	Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter. [GOC:go_curators, GOC:txnOH]
negative regulation of cyclic-nucleotide phosphodiesterase activity	biological process	Any process that stops or reduces the rate of cyclic nucleotide phosphodiesterase activity, the catalysis of the reaction: nucleotide 3',5'-cyclic phosphate + H2O = nucleotide 5'-phosphate. [GOC:ai, GOC:tb]
cardiac muscle tissue morphogenesis	biological process	The process in which the anatomical structures of cardiac muscle tissue are generated and organized. [GOC:devbiol]
heart trabecula formation	biological process	The process of creating a trabecula in the heart. A trabecula is a tissue element in the form of a small beam, strut or rod. [GOC:dph]
ventricular septum morphogenesis	biological process	The developmental process in which a ventricular septum is generated and organized. A ventricular septum is an anatomical structure that separates the lower chambers (ventricles) of the heart from one another. [GOC:dph]
labyrinthine layer development	biological process	The process in which the labyrinthine layer of the placenta progresses, from its formation to its mature state. [GOC:dph]
response to nitric oxide	biological process	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitric oxide stimulus. [GOC:mah, GOC:yaf]
regulation of modification of postsynaptic structure	biological process	Any process that modulates the frequency, rate or extent of modification of postsynaptic structure. [GOC:dos]
regulation protein catabolic process at postsynapse	biological process	Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein at the postsynapse. [PMID:17062563]
peptidyl-proline hydroxylation to 4-hydroxy-L-proline	biological process	The modification of peptidyl-proline to form 4-hydroxy-L-proline; catalyzed by procollagen-proline,2-oxoglutarate-4-dioxygenase. [RESID:AA0030]
cellular response to hypoxia	biological process	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level. [GOC:mah]