Page last updated: 2024-08-07 16:09:32
DNA gyrase subunit A
[no definition available]
Synonyms
EC 5.6.2.2
Research
Bioassay Publications (32)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (12.50) | 29.6817 |
| 2010's | 20 (62.50) | 24.3611 |
| 2020's | 8 (25.00) | 2.80 |
Compounds (14)
Drugs with Inhibition Measurements
Drugs with Other Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| ciprofloxacin | Staphylococcus aureus | CC50 | 101.6667 | 3 | 3 |
| gatifloxacin | Staphylococcus aureus | CC50 | 12.2333 | 3 | 3 |
| novobiocin | Staphylococcus aureus | MIC | 0.0100 | 1 | 1 |
1,3-Dioxane-Linked Novel Bacterial Topoisomerase Inhibitors: Expanding Structural Diversity and the Antibacterial Spectrum.ACS medicinal chemistry letters, , Jun-09, Volume: 13, Issue:6, 2022
Solid-phase synthesis and biological evaluation of piperazine-based novel bacterial topoisomerase inhibitors.Bioorganic & medicinal chemistry letters, , 02-01, Volume: 57, 2022
Optimization of TopoIV Potency, ADMET Properties, and hERG Inhibition of 5-Amino-1,3-dioxane-Linked Novel Bacterial Topoisomerase Inhibitors: Identification of a Lead with Journal of medicinal chemistry, , 10-28, Volume: 64, Issue:20, 2021
Dioxane-Linked Amide Derivatives as Novel Bacterial Topoisomerase Inhibitors against Gram-Positive ACS medicinal chemistry letters, , Dec-10, Volume: 11, Issue:12, 2020
One-pot synthesis and molecular docking of some new spiropyranindol-2-one derivatives as immunomodulatory agents and in vitro antimicrobial potential with DNA gyrase inhibitor.European journal of medicinal chemistry, , Feb-15, Volume: 188, 2020
Virtual Screening Approach and Investigation of Structure-Activity Relationships To Discover Novel Bacterial Topoisomerase Inhibitors Targeting Gram-Positive and Gram-Negative Pathogens.Journal of medicinal chemistry, , 08-22, Volume: 62, Issue:16, 2019
[no title available]Journal of medicinal chemistry, , 03-28, Volume: 62, Issue:6, 2019
Synthesis and anti-staphylococcal activity of novel bacterial topoisomerase inhibitors with a 5-amino-1,3-dioxane linker moiety.Bioorganic & medicinal chemistry letters, , 08-01, Volume: 28, Issue:14, 2018
Discovery and Optimization of Isoquinoline Ethyl Ureas as Antibacterial Agents.Journal of medicinal chemistry, , 05-11, Volume: 60, Issue:9, 2017
Development of a Dual-Acting Antibacterial Agent (TNP-2092) for the Treatment of Persistent Bacterial Infections.Journal of medicinal chemistry, , 07-28, Volume: 59, Issue:14, 2016
Repurposing the antihistamine terfenadine for antimicrobial activity against Staphylococcus aureus.Journal of medicinal chemistry, , Oct-23, Volume: 57, Issue:20, 2014
Design, synthesis, and characterization of novel tetrahydropyran-based bacterial topoisomerase inhibitors with potent anti-gram-positive activity.Journal of medicinal chemistry, , Sep-26, Volume: 56, Issue:18, 2013
Selenophene-containing inhibitors of type IIA bacterial topoisomerases.Journal of medicinal chemistry, , May-12, Volume: 54, Issue:9, 2011
Exploration of the activity of 7-pyrrolidino-8-methoxyisothiazoloquinolones against methicillin-resistant Staphylococcus aureus (MRSA).Journal of medicinal chemistry, , May-12, Volume: 54, Issue:9, 2011
Comparison of in vitro activities of fluoroquinolone-like 2,4- and 1,3-diones.Antimicrobial agents and chemotherapy, , Volume: 54, Issue:7, 2010
In vitro evaluation of CBR-2092, a novel rifamycin-quinolone hybrid antibiotic: studies of the mode of action in Staphylococcus aureus.Antimicrobial agents and chemotherapy, , Volume: 52, Issue:7, 2008
Isothiazoloquinolones with enhanced antistaphylococcal activities against multidrug-resistant strains: effects of structural modifications at the 6-, 7-, and 8-positions.Journal of medicinal chemistry, , Jan-25, Volume: 50, Issue:2, 2007
Dual targeting of DNA gyrase and topoisomerase IV: target interactions of heteroaryl isothiazolones in Staphylococcus aureus.Antimicrobial agents and chemotherapy, , Volume: 51, Issue:7, 2007
Development of a Dual-Acting Antibacterial Agent (TNP-2092) for the Treatment of Persistent Bacterial Infections.Journal of medicinal chemistry, , 07-28, Volume: 59, Issue:14, 2016
In vitro evaluation of CBR-2092, a novel rifamycin-quinolone hybrid antibiotic: studies of the mode of action in Staphylococcus aureus.Antimicrobial agents and chemotherapy, , Volume: 52, Issue:7, 2008
Spiropyrimidinetrione DNA Gyrase Inhibitors with Potent and Selective Antituberculosis Activity.Journal of medicinal chemistry, , 05-12, Volume: 65, Issue:9, 2022
Selenophene-containing inhibitors of type IIA bacterial topoisomerases.Journal of medicinal chemistry, , May-12, Volume: 54, Issue:9, 2011
Exploration of the activity of 7-pyrrolidino-8-methoxyisothiazoloquinolones against methicillin-resistant Staphylococcus aureus (MRSA).Journal of medicinal chemistry, , May-12, Volume: 54, Issue:9, 2011
Isothiazoloquinolones with enhanced antistaphylococcal activities against multidrug-resistant strains: effects of structural modifications at the 6-, 7-, and 8-positions.Journal of medicinal chemistry, , Jan-25, Volume: 50, Issue:2, 2007
Dual targeting of DNA gyrase and topoisomerase IV: target interactions of heteroaryl isothiazolones in Staphylococcus aureus.Antimicrobial agents and chemotherapy, , Volume: 51, Issue:7, 2007
Selenophene-containing inhibitors of type IIA bacterial topoisomerases.Journal of medicinal chemistry, , May-12, Volume: 54, Issue:9, 2011
Exploration of the activity of 7-pyrrolidino-8-methoxyisothiazoloquinolones against methicillin-resistant Staphylococcus aureus (MRSA).Journal of medicinal chemistry, , May-12, Volume: 54, Issue:9, 2011
Isothiazoloquinolones with enhanced antistaphylococcal activities against multidrug-resistant strains: effects of structural modifications at the 6-, 7-, and 8-positions.Journal of medicinal chemistry, , Jan-25, Volume: 50, Issue:2, 2007
Dual targeting of DNA gyrase and topoisomerase IV: target interactions of heteroaryl isothiazolones in Staphylococcus aureus.Antimicrobial agents and chemotherapy, , Volume: 51, Issue:7, 2007
New dual ATP-competitive inhibitors of bacterial DNA gyrase and topoisomerase IV active against ESKAPE pathogens.European journal of medicinal chemistry, , Mar-05, Volume: 213, 2021
Exploring the Chemical Space of Benzothiazole-Based DNA Gyrase B Inhibitors.ACS medicinal chemistry letters, , Dec-10, Volume: 11, Issue:12, 2020
[no title available]Journal of medicinal chemistry, , 03-28, Volume: 62, Issue:6, 2019
New MedChemComm, , Jun-01, Volume: 10, Issue:6, 2019
An optimised series of substituted N-phenylpyrrolamides as DNA gyrase B inhibitors.European journal of medicinal chemistry, , Apr-01, Volume: 167, 2019
Discovery of substituted oxadiazoles as a novel scaffold for DNA gyrase inhibitors.European journal of medicinal chemistry, , Apr-21, Volume: 130, 2017
Discovery and Optimization of Isoquinoline Ethyl Ureas as Antibacterial Agents.Journal of medicinal chemistry, , 05-11, Volume: 60, Issue:9, 2017
New N-phenyl-4,5-dibromopyrrolamides and N-Phenylindolamides as ATPase inhibitors of DNA gyrase.European journal of medicinal chemistry, , Jul-19, Volume: 117, 2016
Discovery of 4,5,6,7-Tetrahydrobenzo[1,2-d]thiazoles as Novel DNA Gyrase Inhibitors Targeting the ATP-Binding Site.Journal of medicinal chemistry, , Jul-23, Volume: 58, Issue:14, 2015
Dual inhibition of Staphylococcus aureus DNA gyrase and topoisomerase IV activity by phenylalanine-derived (Z)-5-arylmethylidene rhodanines.Bioorganic & medicinal chemistry, , Sep-15, Volume: 23, Issue:18, 2015
Structure-guided design and development of novel benzimidazole class of compounds targeting DNA gyraseB enzyme of Staphylococcus aureus.Bioorganic & medicinal chemistry, , Nov-01, Volume: 22, Issue:21, 2014
Kibdelomycin A, a congener of kibdelomycin, derivatives and their antibacterial activities.Bioorganic & medicinal chemistry letters, , Dec-01, Volume: 22, Issue:23, 2012
Novel dual-targeting benzimidazole urea inhibitors of DNA gyrase and topoisomerase IV possessing potent antibacterial activity: intelligent design and evolution through the judicious use of structure-guided design and structure-activity relationships.Journal of medicinal chemistry, , Sep-11, Volume: 51, Issue:17, 2008