pimagedine has been researched along with Necrosis in 14 studies
pimagedine: diamine oxidase & nitric oxide synthase inhibitor; an advanced glycosylation end product inhibitor; used in the treatment of diabetic complications; structure
aminoguanidine : A one-carbon compound whose unique structure renders it capable of acting as a derivative of hydrazine, guanidine or formamide.
Necrosis: The death of cells in an organ or tissue due to disease, injury or failure of the blood supply.
| Excerpt | Relevance | Reference |
|---|---|---|
| "After sham treatment, the necrosis expanded to 8." | 1.32 | Secondary growth of a cortical necrosis: effect of NOS inhibition by aminoguanidine post insult. ( Baethmann, A; Plesnila, N; Rinecker, M; Stoffel, M, 2003) |
| " bolus 10 min prior to trauma (300 mg/kg body weight; n = 10) and a second bolus of the same dosage intraperitoneally 1 h after trauma." | 1.31 | Role of nitric oxide in the secondary expansion of a cortical brain lesion from cold injury. ( Baethmann, A; Eriskat, J; Plesnila, N; Rinecker, M; Stoffel, M, 2001) |
| "Inflammation, demyelination and axonal necrosis were scored in a blinded fashion on spinal cord sections from each mouse." | 1.30 | Nitric oxide synthase inhibitor, aminoguanidine, reduces inflammation and demyelination produced by Theiler's virus infection. ( Cross, AH; Fujinami, RS; Hill, KE; Kurtz, CI; Rose, JW; Tsunoda, I; Wada, Y, 1998) |
| " In this study, the changes in the cellular and extracellular concentrations of these alpha-oxoaldehydes were investigated in murine P388D1 macrophages during necrotic cell death induced by median toxic concentrations of hydrogen peroxide and 1-chloro-2,4-dinitrobenzene (CDNB)." | 1.30 | Accumulation of alpha-oxoaldehydes during oxidative stress: a role in cytotoxicity. ( Abordo, EA; Minhas, HS; Thornalley, PJ, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 5 (35.71) | 18.2507 |
| 2000's | 8 (57.14) | 29.6817 |
| 2010's | 1 (7.14) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ozturk, A | 1 |
| Fırat, C | 1 |
| Parlakpınar, H | 1 |
| Bay-Karabulut, A | 1 |
| Kirimlioglu, H | 1 |
| Gurlek, A | 1 |
| Neufeld, AH | 1 |
| Kawai, Si | 1 |
| Das, S | 1 |
| Vora, S | 1 |
| Gachie, E | 1 |
| Connor, JR | 1 |
| Manning, PT | 1 |
| Kimura, H | 1 |
| Katsuramaki, T | 1 |
| Isobe, M | 1 |
| Nagayama, M | 1 |
| Meguro, M | 1 |
| Kukita, K | 1 |
| Nui, A | 1 |
| Hirata, K | 1 |
| Knight, TR | 1 |
| Fariss, MW | 1 |
| Farhood, A | 1 |
| Jaeschke, H | 1 |
| Rinecker, M | 2 |
| Plesnila, N | 2 |
| Baethmann, A | 2 |
| Stoffel, M | 2 |
| Miyabara, EH | 1 |
| Tostes, RC | 1 |
| Selistre-de-Araújo, HS | 1 |
| Aoki, MS | 1 |
| Moriscot, AS | 1 |
| Rose, R | 1 |
| Banerjee, A | 1 |
| Ramaiah, SK | 1 |
| Lecanu, L | 1 |
| Margaill, I | 1 |
| Boughali, H | 1 |
| Cohen-Tenoudji, B | 1 |
| Boulu, RG | 1 |
| Plotkine, M | 1 |
| Rose, JW | 1 |
| Hill, KE | 1 |
| Wada, Y | 1 |
| Kurtz, CI | 1 |
| Tsunoda, I | 1 |
| Fujinami, RS | 1 |
| Cross, AH | 1 |
| Wada, K | 1 |
| Chatzipanteli, K | 1 |
| Kraydieh, S | 1 |
| Busto, R | 1 |
| Dietrich, WD | 1 |
| Abordo, EA | 1 |
| Minhas, HS | 1 |
| Thornalley, PJ | 1 |
| Eriskat, J | 1 |
| Shiraishi, K | 1 |
| Naito, K | 1 |
| Yoshida, K | 1 |
| Bannai, C | 1 |
| Yamazaki, M | 1 |
| Matsushima, Y | 1 |
| Kunika, K | 1 |
| Itakura, M | 1 |
| Okuda, Y | 1 |
| Yamashita, K | 1 |
14 other studies available for pimagedine and Necrosis
| Article | Year |
|---|---|
Beneficial effects of aminoguanidine on skin flap survival in diabetic rats.
Topics: Animals; Antioxidants; Blood Glucose; Diabetes Complications; Diabetes Mellitus, Experimental; Femal | 2012 |
Loss of retinal ganglion cells following retinal ischemia: the role of inducible nitric oxide synthase.
Topics: Animals; Enzyme Inhibitors; Guanidines; Homoarginine; Ischemia; Male; Necrosis; Neutrophils; Nitric | 2002 |
Role of inducible nitric oxide synthase in pig liver transplantation.
Topics: Animals; Aspartate Aminotransferases; Cold Temperature; Enzyme Inhibitors; Fluorescent Antibody Tech | 2003 |
Role of lipid peroxidation as a mechanism of liver injury after acetaminophen overdose in mice.
Topics: Acetaminophen; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Diet; Drug Overdose; Enzyme | 2003 |
Secondary growth of a cortical necrosis: effect of NOS inhibition by aminoguanidine post insult.
Topics: Animals; Brain Injuries; Cerebral Cortex; Disease Models, Animal; Drug Administration Schedule; Guan | 2003 |
Role of nitric oxide in myotoxic activity induced by crotoxin in vivo.
Topics: Analysis of Variance; Animals; Brazil; Crotalus; Crotoxin; Guanidines; Histological Techniques; Inda | 2004 |
Calpain inhibition attenuates iNOS production and midzonal hepatic necrosis in a repeat dose model of endotoxemia in rats.
Topics: Animals; Anticoagulants; Blood Coagulation; Blotting, Western; Calpain; Carrier Proteins; Chemical a | 2006 |
Deleterious Ca-independent NOS activity after oxidative stress in rat striatum.
Topics: Animals; Calcium; Corpus Striatum; Cyclic N-Oxides; Enzyme Inhibitors; Free Radical Scavengers; Free | 1998 |
Nitric oxide synthase inhibitor, aminoguanidine, reduces inflammation and demyelination produced by Theiler's virus infection.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Axons; Demyelinating Diseases; DNA Frag | 1998 |
Inducible nitric oxide synthase expression after traumatic brain injury and neuroprotection with aminoguanidine treatment in rats.
Topics: Animals; Astrocytes; Brain Injuries; Enzyme Induction; Enzyme Inhibitors; Guanidines; Macrophages; M | 1998 |
Accumulation of alpha-oxoaldehydes during oxidative stress: a role in cytotoxicity.
Topics: Animals; Cell Line; Cell Survival; Deoxyglucose; Dinitrochlorobenzene; Glutathione; Glyoxal; Guanidi | 1999 |
Role of nitric oxide in the secondary expansion of a cortical brain lesion from cold injury.
Topics: Animals; Arginine; Brain; Brain Injuries; Cold Temperature; Enzyme Inhibitors; Guanidines; Male; Nec | 2001 |
Nitric oxide promotes germ cell necrosis in the delayed phase after experimental testicular torsion of rat.
Topics: Animals; Apoptosis; Calpain; DNA Fragmentation; Electrophoresis, Polyacrylamide Gel; Enzyme Activati | 2001 |
Amelioration of dermal lesions in streptozotocin-induced diabetic rats by aminoguanidine.
Topics: Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Electrophoresis, Polyacrylamid | 1992 |