Page last updated: 2024-10-22

pimagedine and Necrosis

pimagedine has been researched along with Necrosis in 14 studies

pimagedine: diamine oxidase & nitric oxide synthase inhibitor; an advanced glycosylation end product inhibitor; used in the treatment of diabetic complications; structure
aminoguanidine : A one-carbon compound whose unique structure renders it capable of acting as a derivative of hydrazine, guanidine or formamide.

Necrosis: The death of cells in an organ or tissue due to disease, injury or failure of the blood supply.

Research Excerpts

ExcerptRelevanceReference
"After sham treatment, the necrosis expanded to 8."1.32Secondary growth of a cortical necrosis: effect of NOS inhibition by aminoguanidine post insult. ( Baethmann, A; Plesnila, N; Rinecker, M; Stoffel, M, 2003)
" bolus 10 min prior to trauma (300 mg/kg body weight; n = 10) and a second bolus of the same dosage intraperitoneally 1 h after trauma."1.31Role of nitric oxide in the secondary expansion of a cortical brain lesion from cold injury. ( Baethmann, A; Eriskat, J; Plesnila, N; Rinecker, M; Stoffel, M, 2001)
"Inflammation, demyelination and axonal necrosis were scored in a blinded fashion on spinal cord sections from each mouse."1.30Nitric oxide synthase inhibitor, aminoguanidine, reduces inflammation and demyelination produced by Theiler's virus infection. ( Cross, AH; Fujinami, RS; Hill, KE; Kurtz, CI; Rose, JW; Tsunoda, I; Wada, Y, 1998)
" In this study, the changes in the cellular and extracellular concentrations of these alpha-oxoaldehydes were investigated in murine P388D1 macrophages during necrotic cell death induced by median toxic concentrations of hydrogen peroxide and 1-chloro-2,4-dinitrobenzene (CDNB)."1.30Accumulation of alpha-oxoaldehydes during oxidative stress: a role in cytotoxicity. ( Abordo, EA; Minhas, HS; Thornalley, PJ, 1999)

Research

Studies (14)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's5 (35.71)18.2507
2000's8 (57.14)29.6817
2010's1 (7.14)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Ozturk, A1
Fırat, C1
Parlakpınar, H1
Bay-Karabulut, A1
Kirimlioglu, H1
Gurlek, A1
Neufeld, AH1
Kawai, Si1
Das, S1
Vora, S1
Gachie, E1
Connor, JR1
Manning, PT1
Kimura, H1
Katsuramaki, T1
Isobe, M1
Nagayama, M1
Meguro, M1
Kukita, K1
Nui, A1
Hirata, K1
Knight, TR1
Fariss, MW1
Farhood, A1
Jaeschke, H1
Rinecker, M2
Plesnila, N2
Baethmann, A2
Stoffel, M2
Miyabara, EH1
Tostes, RC1
Selistre-de-Araújo, HS1
Aoki, MS1
Moriscot, AS1
Rose, R1
Banerjee, A1
Ramaiah, SK1
Lecanu, L1
Margaill, I1
Boughali, H1
Cohen-Tenoudji, B1
Boulu, RG1
Plotkine, M1
Rose, JW1
Hill, KE1
Wada, Y1
Kurtz, CI1
Tsunoda, I1
Fujinami, RS1
Cross, AH1
Wada, K1
Chatzipanteli, K1
Kraydieh, S1
Busto, R1
Dietrich, WD1
Abordo, EA1
Minhas, HS1
Thornalley, PJ1
Eriskat, J1
Shiraishi, K1
Naito, K1
Yoshida, K1
Bannai, C1
Yamazaki, M1
Matsushima, Y1
Kunika, K1
Itakura, M1
Okuda, Y1
Yamashita, K1

Other Studies

14 other studies available for pimagedine and Necrosis

ArticleYear
Beneficial effects of aminoguanidine on skin flap survival in diabetic rats.
    Experimental diabetes research, 2012, Volume: 2012

    Topics: Animals; Antioxidants; Blood Glucose; Diabetes Complications; Diabetes Mellitus, Experimental; Femal

2012
Loss of retinal ganglion cells following retinal ischemia: the role of inducible nitric oxide synthase.
    Experimental eye research, 2002, Volume: 75, Issue:5

    Topics: Animals; Enzyme Inhibitors; Guanidines; Homoarginine; Ischemia; Male; Necrosis; Neutrophils; Nitric

2002
Role of inducible nitric oxide synthase in pig liver transplantation.
    The Journal of surgical research, 2003, May-01, Volume: 111, Issue:1

    Topics: Animals; Aspartate Aminotransferases; Cold Temperature; Enzyme Inhibitors; Fluorescent Antibody Tech

2003
Role of lipid peroxidation as a mechanism of liver injury after acetaminophen overdose in mice.
    Toxicological sciences : an official journal of the Society of Toxicology, 2003, Volume: 76, Issue:1

    Topics: Acetaminophen; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Diet; Drug Overdose; Enzyme

2003
Secondary growth of a cortical necrosis: effect of NOS inhibition by aminoguanidine post insult.
    Acta neurochirurgica, 2003, Volume: 145, Issue:11

    Topics: Animals; Brain Injuries; Cerebral Cortex; Disease Models, Animal; Drug Administration Schedule; Guan

2003
Role of nitric oxide in myotoxic activity induced by crotoxin in vivo.
    Toxicon : official journal of the International Society on Toxinology, 2004, Mar-15, Volume: 43, Issue:4

    Topics: Analysis of Variance; Animals; Brazil; Crotalus; Crotoxin; Guanidines; Histological Techniques; Inda

2004
Calpain inhibition attenuates iNOS production and midzonal hepatic necrosis in a repeat dose model of endotoxemia in rats.
    Toxicologic pathology, 2006, Volume: 34, Issue:6

    Topics: Animals; Anticoagulants; Blood Coagulation; Blotting, Western; Calpain; Carrier Proteins; Chemical a

2006
Deleterious Ca-independent NOS activity after oxidative stress in rat striatum.
    Neuroreport, 1998, Feb-16, Volume: 9, Issue:3

    Topics: Animals; Calcium; Corpus Striatum; Cyclic N-Oxides; Enzyme Inhibitors; Free Radical Scavengers; Free

1998
Nitric oxide synthase inhibitor, aminoguanidine, reduces inflammation and demyelination produced by Theiler's virus infection.
    Journal of neuroimmunology, 1998, Volume: 81, Issue:1-2

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Axons; Demyelinating Diseases; DNA Frag

1998
Inducible nitric oxide synthase expression after traumatic brain injury and neuroprotection with aminoguanidine treatment in rats.
    Neurosurgery, 1998, Volume: 43, Issue:6

    Topics: Animals; Astrocytes; Brain Injuries; Enzyme Induction; Enzyme Inhibitors; Guanidines; Macrophages; M

1998
Accumulation of alpha-oxoaldehydes during oxidative stress: a role in cytotoxicity.
    Biochemical pharmacology, 1999, Aug-15, Volume: 58, Issue:4

    Topics: Animals; Cell Line; Cell Survival; Deoxyglucose; Dinitrochlorobenzene; Glutathione; Glyoxal; Guanidi

1999
Role of nitric oxide in the secondary expansion of a cortical brain lesion from cold injury.
    Journal of neurotrauma, 2001, Volume: 18, Issue:4

    Topics: Animals; Arginine; Brain; Brain Injuries; Cold Temperature; Enzyme Inhibitors; Guanidines; Male; Nec

2001
Nitric oxide promotes germ cell necrosis in the delayed phase after experimental testicular torsion of rat.
    Biology of reproduction, 2001, Volume: 65, Issue:2

    Topics: Animals; Apoptosis; Calpain; DNA Fragmentation; Electrophoresis, Polyacrylamide Gel; Enzyme Activati

2001
Amelioration of dermal lesions in streptozotocin-induced diabetic rats by aminoguanidine.
    Diabetes research (Edinburgh, Scotland), 1992, Volume: 20, Issue:4

    Topics: Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Electrophoresis, Polyacrylamid

1992