| Flora | Rank | Flora Definition | Family | Family Definition |
|---|---|---|---|---|
| Pterocarpus | genus | A plant genus of the family FABACEAE. Members contain TRITERPENES.[MeSH] | Fabaceae | The large family of plants characterized by pods. Some are edible and some cause LATHYRISM or FAVISM and other forms of poisoning. Other species yield useful materials like gums from ACACIA and various LECTINS like PHYTOHEMAGGLUTININS from PHASEOLUS. Many of them harbor NITROGEN FIXATION bacteria on their roots. Many but not all species of beans belong to this family.[MeSH] |
| ID Source | ID |
|---|---|
| PubMed CID | 5281727 |
| CHEMBL ID | 83527 |
| CHEBI ID | 8630 |
| SCHEMBL ID | 563218 |
| SCHEMBL ID | 20063 |
| MeSH ID | M0280256 |
| Synonym |
|---|
| AC-5283 |
| chebi:8630 , |
| pterostilben |
| 4-(3,5-dimethoxystyryl)phenol |
| CHEMBL83527 , |
| LS-14484 |
| BB 0262300 |
| gtpl2681 |
| nsc-613735 |
| nsc613735 |
| tero-still-bean |
| pteropure |
| pterostilbene, >=97% (hplc), solid |
| MEGXP0_000345 |
| NCGC00180691-01 |
| 3',5'-dimethoxy-4trans-stilbenol |
| trans-3,5-dimethoxy-4'-hydroxystilbene |
| phenol, 4-((1e)-2-(3,5-dimethoxyphenyl)ethenyl)- |
| pterostilbene, (e)- |
| 4-((e)-2-(3,5-dimethoxyphenyl)ethenyl)phenol |
| 3',5'-dimethoxy-4e-stilbenol |
| 3',5'-dimethoxy-resveratrol |
| 4trans-(2-(3,5-dimethoxyphenyl)ethenyl)phenol |
| 3,5-dimethoxy-4'-hydroxy-trans-stilbene |
| trans-pterostilbene |
| pterostilbene , |
| 537-42-8 |
| MLS000759434 |
| cpd000440694 , |
| ACON1_000305 |
| smr000440694 |
| MLS000863581 |
| pterostilbene, pterocarpus marsupium |
| 4-[(e)-2-(3,5-dimethoxyphenyl)ethenyl]phenol |
| LMPK13090015 |
| HMS2051B10 |
| 4''-hydroxy-3,5-dimethoxy stilbene |
| 4-[(e)-2-(3,5-dimethoxy-phenyl)-vinyl]-phenol |
| e 4-[2-(3,5-dimethoxy-phenyl)-vinyl]-phenol |
| 3,5-dimethoxy-4''-hydroxyl-trans-stilbene |
| (e)-4-(3,5-dimethoxystyryl)phenol |
| bdbm50131688 |
| 4-[2-(3,5-dimethoxy-phenyl)-vinyl]-phenol |
| AKOS000277651 |
| 4-[(e)-2-(3,5-dimethoxyphenyl)vinyl]phenol;pterostilbene |
| A829757 |
| P1924 |
| trans-1-(3,5-dimethoxyphenyl)-2-(4-hydroxyphenyl)ethylene |
| 4'-hydroxy-3,5-dimethoxy-trans-stilbene |
| MLS001424135 |
| phenol, 4-(2-(3,5-dimethoxyphenyl)ethenyl)-, (e)- |
| 26r60s6a5i , |
| unii-26r60s6a5i |
| 4-(2-(3,5-dimethoxyphenyl)ethenyl)phenol |
| 4-stilbenol, 3',5'-dimethoxy-, (e)- |
| 3',5'-dimethoxy-4-stilbenol |
| HMS2270J16 |
| S3937 |
| CCG-101015 |
| (e)-3',5'-dimethoxy-4-stilbenol |
| (e)-1-hydroxy-4-(3,5-dimethoxy)styrylbenzene |
| 4-[(e)-2-(3,5-dimethoxyphenyl)vinyl]phenol |
| (e)-4'-hydroxy-3,5-dimethoxystilbene |
| 18259-15-9 |
| SCHEMBL563218 |
| AKOS025310510 |
| NC00265 |
| SCHEMBL20063 |
| W-203025 |
| phenol, 4-[(1e)-2-(3,5-dimethoxyphenyl)ethenyl]- |
| 4-((1e)-2-(3,5-dimethoxyphenyl)ethenyl)phenol |
| eh-301 component pterostilbene |
| pterostilbene [who-dd] |
| HY-N0828 |
| DTXSID9041106 , |
| 4-[(1e)-2-(3,5-dimethoxyphenyl)ethenyl]phenol |
| J-523927 |
| phenol,4-[2-(3,5-dmethoxyphenyl)ethenyl]- |
| CS-W008773 |
| 4'-hydroxy-3,5-dimethoxystilbene |
| 4-((e)-2-(3,5-dimethoxyphenyl)vinyl)phenol |
| dtxcid7021106 |
| 4-?[2-?(3,?5-?dimethoxyphenyl)?ethenyl]?-phenol |
| BCP22675 |
| Q2908011 |
| Z2065715198 |
| AS-13710 |
| AMY24840 |
| phenol, 4-[2-(3,5-dimethoxyphenyl)ethenyl]- |
| EN300-18388389 |
Pterostilbene is a stilbenoid chemically related to resveratrol, and has potential for the treatment of cancers. It is a revesterol analog with a long bioavailability and potent anti-inflammatory activity.
Pterostilbene has been shown to reduce weight gain, liver fat, plasma cholesterol, adiposity, inflammatory biomarkers, blood glucose, and other physiological characteristics of metabolic diseases. The drug has notable cardioprotective effects, but its main mechanisms are not fully understood.
Pterostilbene can suppress hRECs over proliferation, decrease TNF-α and IL-1β, inhibit NF-κB protein expression, reduce ROS production, and increase SOD activity markedly compared with high glucose group. It was found to inhibit the cell proliferating factors like Akt, Bcl-2 and induced the mitochondrial apoptotic signals like Bax.
Pterostilbene treatment to fructose-fed diabetic rats significantly decreased HOMA-IR (p<0.001) values. At concentrations that demonstrated over 75% cell viability, the drug significantly increased gene expression of ACO, CPT-1, and PPAR-α.
| Excerpt | Reference | Relevance |
|---|---|---|
| " Following a 24-hour incubation of a toxic concentration of CEES (1000 μmol L-1), we used the MTT [3-(4,5-dimethylthiazol- 2-yl)-2,5-diphenyltetrazolium bromide] test to analyse cell viability." | ( Ebselen analogues reduce 2-chloroethyl ethyl sulphide toxicity in A-431 cells. Billack, B; Pietka-Ottlik, M; Pino, MA, 2013) | 0.39 |
| " Furthermore, these toxic effects have not been fully explored." | ( Modulation of Innate Immune Toxicity by Silver Nanoparticle Exposure and the Preventive Effects of Pterostilbene. Chen, RJ; Chen, YY; Huang, CC; Lee, YH; Pranata, R; Wang, YJ; Wu, YH, 2021) | 0.84 |
| " In the current study, it has been demonstrated that PTS could enhance the level of glyoxalase 1 (GLO-1) and elevate glutathione (GSH) content to active the glyoxalase system, resulting in elimination of the toxic MGO as well as advanced glycation end products (AGEs) in HUVECs." | ( Pterostilbene prevents methylglyoxal-induced cytotoxicity in endothelial cells by regulating glyoxalase, oxidative stress and apoptosis. Chen, ZQ; Gu, WT; Nie, H; Tang, D; Wang, SM; Xiao, W; Xu, SH; Xu, YH; Zhang, LY; Zhang, ZT, 2021) | 2.06 |
Pterostilbene exhibits much greater bioavailability compared with other stil bene compounds. Other natural stilbenes derived from resveratrol display higher oral bioavailability and bioactivity than the parent compound, but are far less abundant in natural sources.
| Excerpt | Reference | Relevance |
|---|---|---|
| "5 mL/min/kg, respectively, while its absolute oral bioavailability was 12." | ( Determination of pterostilbene in rat plasma by a simple HPLC-UV method and its application in pre-clinical pharmacokinetic study. Ho, PC; Lin, HS; Yue, BD, 2009) | 0.69 |
| "When administered orally, pterostilbene demonstrates greater bioavailability and total plasma levels of both the parent compound and metabolites than does resveratrol." | ( Pharmacokinetics, oral bioavailability, and metabolic profile of resveratrol and its dimethylether analog, pterostilbene, in rats. Huang, Z; Kapetanovic, IM; McCormick, DL; Muzzio, M; Thompson, TN, 2011) | 0.88 |
| " Overall, the results demonstrated that pterostilbene had more potent inhibitory effects on colon cancer cells than resveratrol, which may be associated with the superior bioavailability of pterostilbene to resveratrol." | ( Inhibitory effects of resveratrol and pterostilbene on human colon cancer cells: a side-by-side comparison. Decker, EA; Dong, P; McClements, DJ; Nutakul, W; Qiu, P; Sobers, HS; Xiao, H, 2011) | 0.91 |
| " Additionally, preliminary studies show that pterostilbene exhibits much greater bioavailability compared with other stilbene compounds; however the exact pharmacologic mechanism of pterostilbene and its effects in humans are still under investigation." | ( Pterostilbene and cancer: current review. McCormack, D; McFadden, D, 2012) | 2.08 |
| " This study aimed to investigate the impacts of aqueous solubility, fasting, dose escalation, and dosing route on its bioavailability in Sprague-Dawley rats." | ( Pharmacokinetics of pterostilbene in Sprague-Dawley rats: the impacts of aqueous solubility, fasting, dose escalation, and dosing route on bioavailability. Ho, PC; Lin, HS; Yeo, SC, 2013) | 0.71 |
| " When given in oral suspension (15 mg/kg), PTS had relatively low bioavailability (F = 15." | ( Pharmacokinetics of pterostilbene in Sprague-Dawley rats: the impacts of aqueous solubility, fasting, dose escalation, and dosing route on bioavailability. Ho, PC; Lin, HS; Yeo, SC, 2013) | 0.71 |
| "Aqueous solubility was identified as a barrier to its oral bioavailability while solubilizing PTS with HP-β-CD substantially increased its bioavailability; dose manipulation was a practical strategy to enhance its bioavailability and systemic exposure; and its delivery through oral mucosa was feasible." | ( Pharmacokinetics of pterostilbene in Sprague-Dawley rats: the impacts of aqueous solubility, fasting, dose escalation, and dosing route on bioavailability. Ho, PC; Lin, HS; Yeo, SC, 2013) | 0.71 |
| " It has increased bioavailability in comparison to other stilbene compounds, which may enhance its dietary benefit and possibly contribute to a valuable clinical effect." | ( A review of pterostilbene antioxidant activity and disease modification. McCormack, D; McFadden, D, 2013) | 0.77 |
| " However, the higher in vivo bioavailability of pterostilbene represents a fundamental advantage." | ( Pterostilbene: Biomedical applications. Asensi, M; Estrela, JM; Mena, S; Ortega, A; Rodriguez, ML, ) | 1.83 |
| "Pterostilbene, a methoxylated analog of Resveratrol, is gradually gaining more importance as a therapeutic drug owing to its higher lipophilicity, bioavailability and biological activity than Resveratrol." | ( Protective effect of Pterostilbene against free radical mediated oxidative damage. Acharya, JD; Ghaskadbi, SS, 2013) | 2.15 |
| " Oral administration (same dose) resulted in moderate Pt bioavailability (∼35%) and in an increased abundance of Pt-S in blood (AUC(Pt)/AUC(Pt-S) ∼0." | ( Pharmacokinetics and tissue distribution of pterostilbene in the rat. Azzolini, M; Biasutto, L; La Spina, M; Mattarei, A; Paradisi, C; Zoratti, M, 2014) | 0.66 |
| " The validated method was applied to the study of bioavailability and tissue distribution of PTS in normal and Lewis lung carcinoma (LLC) bearing mice." | ( UPLC-MS method for quantification of pterostilbene and its application to comparative study of bioavailability and tissue distribution in normal and Lewis lung carcinoma bearing mice. Chen, B; Deng, L; Deng, Y; Li, Y; Zhang, X, 2015) | 0.69 |
| " Other natural stilbenes derived from resveratrol such as pterostilbene or piceatannol, display higher oral bioavailability and bioactivity than the parent compound, but are far less abundant in natural sources." | ( Production of highly bioactive resveratrol analogues pterostilbene and piceatannol in metabolically engineered grapevine cell cultures. Bru-Martínez, R; Cusidó, RM; Martínez-Márquez, A; Morante-Carriel, JA; Palazon, J; Ramírez-Estrada, K, 2016) | 0.93 |
| "Pterostilbene, an analog of resveratrol increasing bioavailability has shown to offer antioxidant and anticancer properties in vitro and in vivo." | ( Pterostilbene induces apoptosis through caspase activation in ovarian cancer cells. Chen, Y; Dong, J; Guo, H, 2016) | 3.32 |
| " However, the greater in vivo bioavailability of PS, as compared to resveratrol, is an added advantage for its efficacy." | ( Promising therapeutic potential of pterostilbene and its mechanistic insight based on preclinical evidence. Kosuru, R; Prakash, S; Rai, U; Singh, A; Singh, S, 2016) | 0.71 |
| "Pterostilbene, a structural analog of resveratrol, has higher oral bioavailability and bioactivity than that of the parent compound; but is far less abundant in natural sources." | ( De novo biosynthesis of pterostilbene in an Escherichia coli strain using a new resveratrol O-methyltransferase from Arabidopsis. Heo, KT; Hong, YS; Kang, SY, 2017) | 2.2 |
| "The biomedical effects of the natural phenol pterostilbene are of great interest but its bioavailability is negatively affected by the phenolic group in position 4' which is an ideal target for the conjugative enzymes of phase II metabolism." | ( New natural amino acid-bearing prodrugs boost pterostilbene's oral pharmacokinetic and distribution profile. Azzolini, M; Biasutto, L; Chiodarelli, G; Fanin, M; La Spina, M; Mattarei, A; Paradisi, C; Romio, M; Zoratti, M, 2017) | 0.97 |
| " However, a key problem is their short half-life and low bioavailability under in vivo conditions." | ( Polyphenolic Phytochemicals in Cancer Prevention and Therapy: Bioavailability versus Bioefficacy. Benlloch, M; Castellano, G; Dellinger, RW; Estrela, JM; Mena, S; Obrador, E; Salvador, R, 2017) | 0.46 |
| " bioavailability promoted by the presence of HPβCD in the complex." | ( Pterostilbene reduces oxidative stress, prevents hypertrophy and preserves systolic function of right ventricle in cor pulmonale model. Belló-Klein, A; Bianchi, SE; Campos-Carraro, C; Colombo, R; Dos Santos Lacerda, D; Duarte Ortiz, V; Gazzi de Lima-Seolin, B; Linck Bassani, V; Poletto Bonetto, JH; Sander da Rosa Araujo, A; Türck, P, 2017) | 1.9 |
| " Nonetheless, the low bioavailability of resveratrol has reduced its attractiveness as a potential anti-cancer treatment." | ( Pterostilbene Suppresses Ovarian Cancer Growth via Induction of Apoptosis and Blockade of Cell Cycle Progression Involving Inhibition of the STAT3 Pathway. Dellinger, TH; Finlay, J; Glackin, CA; Han, ES; Lowe, G; Roberts, CM; Wen, W, 2018) | 1.92 |
| " Moreover, pterostilbene exhibits much greater bioavailability and bioactivity than resveratrol which warrants further investigation in the anti-cancer functions and mechanisms." | ( [Emerging Actions of Pterostilebene on Cancer Research]. Di, S; Gao, Y; Li, X; Ma, Z; Xu, L; Yan, X; Zhang, H; Zhang, J; Zhang, X, 2018) | 0.87 |
| " Its high bioavailability is a major advantage for possible biomedical applications." | ( Pterostilbene Improves Cognitive Performance in Aged Rats: An in Vivo Study. Azzolini, M; Berardi, N; Biasutto, L; La Spina, M; Peruzzo, R; Sale, A; Sansevero, G; Zoratti, M, 2019) | 1.96 |
| "Pterostilbene, a phenolic compound derived from resveratrol, possesses greater bioavailability than its parent compound due to the presence of two methoxyl groups." | ( Effects of Pterostilbene on Diabetes, Liver Steatosis and Serum Lipids. Aguirre, L; Fernández-Quintela, A; Gómez-Zorita, S; Milton-Laskíbar, I; Portillo, MP; Xiao, J, 2021) | 2.45 |
| " These results suggest that pterostilbene might be a potential anticancer agent targeting both cancer cells and cancer stem-like cells of cervical cancer via the superior bioavailability to resveratrol." | ( Pterostilbene Suppresses both Cancer Cells and Cancer Stem-Like Cells in Cervical Cancer with Superior Bioavailability to Resveratrol. Choi, YS; Han, JM; Jung, HJ; Shin, HJ, 2020) | 2.29 |
| " These findings indicate that RA-based self-assembled ultrasmall nanomicelles demonstrate tremendous potential toward the improvement in the ocular bioavailability as well as a therapeutic effect of poor aqueous soluble drugs such as Pt." | ( Novel ultrasmall nanomicelles based on rebaudioside A: A potential nanoplatform for the ocular delivery of pterostilbene. Song, K; Sun, M; Wu, X; Xie, W; Xin, M; Zhang, F, 2020) | 0.77 |
| " However, most of them are rapidly metabolized and excreted, yielding very low phenolic bioavailability what makes it difficult to find out which are the mechanisms responsible for the observed bioactivity." | ( Neuroprotective and Anti-inflammatory Effects of Pterostilbene Metabolites in Human Neuroblastoma SH-SY5Y and RAW 264.7 Macrophage Cells. de-Paz, MV; Lucas, R; Morales, JC; Peñalver, P; Zodio, S, 2020) | 0.81 |
| "Pterostilbene is a revesterol analog with a long bioavailability and having potent anti-inflammatory activity in animal studies." | ( Pterostilbene exert an anti-arthritic effect by attenuating inflammation, oxidative stress, and alteration of gut microbiota. Ding, H; Ding, X; Han, J; Li, X; Liu, Y; Rui, Z; Yuan, Y; Zhang, L, 2022) | 3.61 |
| " However, the therapeutic outcomes of PS are limited by potential side effects associated with the systemic exposure and the modest bioavailability afforded by its oral administration." | ( Oral Delivery of Pterostilbene by L-Arginine-Mediated "Nano-Bomb" Carrier for the Treatment of Ulcerative Colitis. Cao, Y; Li, R; Ma, Y; Wei, W; Yan, X; Yang, M; Zhang, M; Zhang, Y, 2022) | 1.06 |
| " Indeed, due to its higher bioavailability paired with reduced toxicity compared to other stilbenes, PTS has become an attractive drug candidate for the treatment of several disease conditions, including diabetes, cancer, cardiovascular disease, neurodegenerative disorders, and aging." | ( New Insights into Dietary Pterostilbene: Sources, Metabolism, and Health Promotion Effects. Ganesan, K; Mohandas, S; Nagarajan, S; Ramkumar, KM; Xu, B, 2022) | 1.02 |
Pterostilbene was shown to partially prevent high-fat high-fructose feeding induced liver steatosis in rats.
| Role | Description |
|---|---|
| antioxidant | A substance that opposes oxidation or inhibits reactions brought about by dioxygen or peroxides. |
| antineoplastic agent | A substance that inhibits or prevents the proliferation of neoplasms. |
| neurotransmitter | An endogenous compound that is used to transmit information across the synapse between a neuron and another cell. |
| plant metabolite | Any eukaryotic metabolite produced during a metabolic reaction in plants, the kingdom that include flowering plants, conifers and other gymnosperms. |
| apoptosis inducer | Any substance that induces the process of apoptosis (programmed cell death) in multi-celled organisms. |
| neuroprotective agent | Any compound that can be used for the treatment of neurodegenerative disorders. |
| anti-inflammatory agent | Any compound that has anti-inflammatory effects. |
| radical scavenger | A role played by a substance that can react readily with, and thereby eliminate, radicals. |
| hypoglycemic agent | A drug which lowers the blood glucose level. |
| [role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] | |
| Class | Description |
|---|---|
| stilbenol | Any stilbenoid with at least one phenolic group. |
| methoxybenzenes | Any aromatic ether that consists of a benzene skeleton substituted with one or more methoxy groups. |
| diether | A polyether in which the number of ether linkages is 2. |
| [compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] | |
| Pathway | Proteins | Compounds |
|---|---|---|
| pterostilbene biosynthesis | 1 | 6 |
| Protein | Taxonomy | Measurement | Average (µ) | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| Chain A, 2-oxoglutarate Oxygenase | Homo sapiens (human) | Potency | 25.1189 | 0.1778 | 14.3909 | 39.8107 | AID2147 |
| Luciferase | Photinus pyralis (common eastern firefly) | Potency | 13.4591 | 0.0072 | 15.7588 | 89.3584 | AID588342 |
| glp-1 receptor, partial | Homo sapiens (human) | Potency | 5.0119 | 0.0184 | 6.8060 | 14.1254 | AID624417 |
| BRCA1 | Homo sapiens (human) | Potency | 17.7828 | 0.8913 | 7.7225 | 25.1189 | AID624202 |
| phosphopantetheinyl transferase | Bacillus subtilis | Potency | 56.2341 | 0.1413 | 37.9142 | 100.0000 | AID1490 |
| TDP1 protein | Homo sapiens (human) | Potency | 22.1427 | 0.0008 | 11.3822 | 44.6684 | AID686978; AID686979 |
| Microtubule-associated protein tau | Homo sapiens (human) | Potency | 11.2202 | 0.1800 | 13.5574 | 39.8107 | AID1460 |
| lysosomal alpha-glucosidase preproprotein | Homo sapiens (human) | Potency | 11.2202 | 0.0366 | 19.6376 | 50.1187 | AID2100 |
| NPC intracellular cholesterol transporter 1 precursor | Homo sapiens (human) | Potency | 2.5119 | 0.0126 | 2.4518 | 25.0177 | AID485313 |
| mitogen-activated protein kinase 1 | Homo sapiens (human) | Potency | 39.8107 | 0.0398 | 16.7842 | 39.8107 | AID1454 |
| ras-related protein Rab-9A | Homo sapiens (human) | Potency | 3.1623 | 0.0002 | 2.6215 | 31.4954 | AID485297 |
| nuclear receptor ROR-gamma isoform 1 | Mus musculus (house mouse) | Potency | 6.4468 | 0.0079 | 8.2332 | 1,122.0200 | AID2546; AID2551 |
| geminin | Homo sapiens (human) | Potency | 0.1158 | 0.0046 | 11.3741 | 33.4983 | AID624297 |
| TAR DNA-binding protein 43 | Homo sapiens (human) | Potency | 28.1838 | 1.7783 | 16.2081 | 35.4813 | AID652104 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
| Protein | Taxonomy | Measurement | Average | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| Tyrosine-protein kinase ABL1 | Homo sapiens (human) | IC50 (µMol) | 10.0000 | 0.0001 | 0.7128 | 10.0000 | AID264592 |
| Cytochrome P450 1A1 | Homo sapiens (human) | Ki | 0.5700 | 0.0120 | 0.9469 | 3.8000 | AID1452982 |
| ATP-dependent translocase ABCB1 | Homo sapiens (human) | IC50 (µMol) | 42.0000 | 0.0002 | 2.3185 | 10.0000 | AID264590 |
| Neuronal acetylcholine receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | IC50 (µMol) | 0.8200 | 0.0003 | 0.3095 | 2.3000 | AID370920 |
| Polyunsaturated fatty acid 5-lipoxygenase | Homo sapiens (human) | IC50 (µMol) | 4.5867 | 0.0001 | 1.6847 | 9.3200 | AID1570236; AID1570237; AID1614268 |
| Breakpoint cluster region protein | Homo sapiens (human) | IC50 (µMol) | 10.0000 | 0.0003 | 0.6200 | 10.0000 | AID264592 |
| Neuronal acetylcholine receptor subunit beta-2 | Rattus norvegicus (Norway rat) | IC50 (µMol) | 0.8200 | 0.0003 | 0.3209 | 2.3000 | AID370920 |
| Ribosyldihydronicotinamide dehydrogenase [quinone] | Homo sapiens (human) | IC50 (µMol) | 5.1000 | 0.0027 | 1.6287 | 9.9000 | AID770333 |
| Prostaglandin G/H synthase 1 | Homo sapiens (human) | IC50 (µMol) | 0.7000 | 0.0002 | 1.5574 | 10.0000 | AID370919 |
| Prostaglandin G/H synthase 2 | Homo sapiens (human) | IC50 (µMol) | 0.8200 | 0.0001 | 0.9950 | 10.0000 | AID370920 |
| Cytochrome P450 1B1 | Homo sapiens (human) | Ki | 0.9100 | 0.0030 | 0.9741 | 7.4600 | AID1452983 |
| Transient receptor potential cation channel subfamily A member 1 | Rattus norvegicus (Norway rat) | IC50 (µMol) | 7.5000 | 0.4500 | 3.4243 | 7.5000 | AID1272522 |
| Transient receptor potential cation channel subfamily V member 1 | Homo sapiens (human) | IC50 (µMol) | 10.0000 | 0.0002 | 0.6060 | 10.0000 | AID1272526 |
| NACHT, LRR and PYD domains-containing protein 3 | Mus musculus (house mouse) | IC50 (µMol) | 10.0000 | 0.0004 | 1.4419 | 10.0000 | AID1773851 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
| Protein | Taxonomy | Measurement | Average | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| Transient receptor potential cation channel subfamily A member 1 | Rattus norvegicus (Norway rat) | EC50 (µMol) | 3.6000 | 0.0600 | 2.2223 | 8.4000 | AID1272523 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
| Protein | Taxonomy | Measurement | Average | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| FAD-linked sulfhydryl oxidase ALR | Homo sapiens (human) | AC50 | 0.7780 | 0.0050 | 3.2126 | 22.7870 | AID493248 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID1069488 | Inhibition of Rac1 in human MDA-MB-231 cells at 2 uM after 30 mins by G-LISA activity assay | 2014 | Bioorganic & medicinal chemistry letters, Feb-15, Volume: 24, Issue:4 | Urokinase-type plasminogen activator expression and Rac1/WAVE-2/Arp2/3 pathway are blocked by pterostilbene to suppress cell migration and invasion in MDA-MB-231 cells. |
| AID1183065 | Antifungal activity against Candida guilliermondii ATCC 6260 assessed as growth inhibition after 48 hrs by broth microdilution method | 2014 | Journal of natural products, Jul-25, Volume: 77, Issue:7 | Antifungal activity of resveratrol derivatives against Candida species. |
| AID1083164 | Antifungal activity against Eutypa lata BX1-10 assessed as growth inhibition measured after 1 to 10 days | 2012 | Journal of agricultural and food chemistry, Dec-05, Volume: 60, Issue:48 | Phenolics and their antifungal role in grapevine wood decay: focus on the Botryosphaeriaceae family. |
| AID1069489 | Inhibition of DNA binding of NF-kappaB (unknown origin) on uPA promoter at 10 uM by ChIP assay | 2014 | Bioorganic & medicinal chemistry letters, Feb-15, Volume: 24, Issue:4 | Urokinase-type plasminogen activator expression and Rac1/WAVE-2/Arp2/3 pathway are blocked by pterostilbene to suppress cell migration and invasion in MDA-MB-231 cells. |
| AID510869 | Cytotoxicity against human Caco-2 cells after 3 days by [3H]thymidine incorporation assay | 2010 | European journal of medicinal chemistry, Sep, Volume: 45, Issue:9 | In vitro and in vivo studies on stilbene analogs as potential treatment agents for colon cancer. |
| AID1083154 | Antifungal activity against Diplodia seriata BoF98-1 assessed as growth inhibition measured after 1 to 10 days | 2012 | Journal of agricultural and food chemistry, Dec-05, Volume: 60, Issue:48 | Phenolics and their antifungal role in grapevine wood decay: focus on the Botryosphaeriaceae family. |
| AID1371456 | Cmax in mouse at 100 mg/kg, po by HPLC method | 2017 | Journal of medicinal chemistry, 12-14, Volume: 60, Issue:23 | Polyphenolic Phytochemicals in Cancer Prevention and Therapy: Bioavailability versus Bioefficacy. |
| AID1272525 | Agonist activity at human TRPV1 expressed in HEK293 cells assessed as induction of intracellular calcium level relative to allyl isothiocyanate | 2016 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 26, Issue:3 | TRPA1 channels as targets for resveratrol and related stilbenoids. |
| AID403243 | Antihyperglycemic activity in streptozotocin-induced nonfasted diabetic rat assessed as decrease in blood glucose level at 20 mg/kg, po administered for 3 days measured 1 hr after last dose | 1997 | Journal of natural products, Jun, Volume: 60, Issue:6 | Antihyperglycemic activity of phenolics from Pterocarpus marsupium. |
| AID264591 | Proapoptotic activity against MDR human HL60R cell line | 2006 | Journal of medicinal chemistry, May-18, Volume: 49, Issue:10 | Identification of a terphenyl derivative that blocks the cell cycle in the G0-G1 phase and induces differentiation in leukemia cells. |
| AID1354541 | Antiinflammatory activity in mouse J774 cells assessed as reduction in LPS-induced IL6 expression after 24 hrs by ELISA | 2018 | Journal of natural products, 05-25, Volume: 81, Issue:5 | Natural Stilbenoids Have Anti-Inflammatory Properties in Vivo and Down-Regulate the Production of Inflammatory Mediators NO, IL6, and MCP1 Possibly in a PI3K/Akt-Dependent Manner. |
| AID1183064 | Antifungal activity against Candida glabrata ATCC 90030 assessed as growth inhibition after 48 hrs by broth microdilution method | 2014 | Journal of natural products, Jul-25, Volume: 77, Issue:7 | Antifungal activity of resveratrol derivatives against Candida species. |
| AID1183068 | Antifungal activity against Candida krusei ATCC 6258 assessed as growth inhibition after 48 hrs by broth microdilution method | 2014 | Journal of natural products, Jul-25, Volume: 77, Issue:7 | Antifungal activity of resveratrol derivatives against Candida species. |
| AID1183062 | Antifungal activity against Candida dubliniensis ATCC MYA-646 assessed as growth inhibition after 48 hrs by broth microdilution method | 2014 | Journal of natural products, Jul-25, Volume: 77, Issue:7 | Antifungal activity of resveratrol derivatives against Candida species. |
| AID1083160 | Antifungal activity against Neofusicoccum luteum CBS110299 assessed as growth inhibition measured after 1 to 10 days | 2012 | Journal of agricultural and food chemistry, Dec-05, Volume: 60, Issue:48 | Phenolics and their antifungal role in grapevine wood decay: focus on the Botryosphaeriaceae family. |
| AID264589 | Proapoptotic activity against human HL60 cell line | 2006 | Journal of medicinal chemistry, May-18, Volume: 49, Issue:10 | Identification of a terphenyl derivative that blocks the cell cycle in the G0-G1 phase and induces differentiation in leukemia cells. |
| AID1309126 | Activation of Nrf2 in mouse MIN6 cells assessed as upregulation of GST1-ARE-luciferase incubated for 8 hrs by luminometric assay relative to control | 2016 | Bioorganic & medicinal chemistry, 08-15, Volume: 24, Issue:16 | Pterostilbene-mediated Nrf2 activation: Mechanistic insights on Keap1:Nrf2 interface. |
| AID1083155 | Antifungal activity against Diplodia seriata BoF99-1 assessed as growth inhibition measured after 1 to 10 days | 2012 | Journal of agricultural and food chemistry, Dec-05, Volume: 60, Issue:48 | Phenolics and their antifungal role in grapevine wood decay: focus on the Botryosphaeriaceae family. |
| AID370921 | Inhibition of TNFalpha induced NF-kappaB activation in human 293 cells after 24 hrs by luciferase reporter gene assay | 2009 | Bioorganic & medicinal chemistry, Feb-01, Volume: 17, Issue:3 | Synthesis and biological evaluation of a library of resveratrol analogues as inhibitors of COX-1, COX-2 and NF-kappaB. |
| AID57707 | In vitro growth inhibition of DU-145 (human prostate carcinoma) cell line. | 2002 | Journal of medicinal chemistry, Jun-06, Volume: 45, Issue:12 | Antineoplastic agents. 465. Structural modification of resveratrol: sodium resverastatin phosphate. |
| AID1081912 | Antifungal activity against Botryotinia fuckeliana assessed as growth inhibition after 48 hr by NCCLS M27-A broth microdilution method | 2011 | Journal of agricultural and food chemistry, Mar-09, Volume: 59, Issue:5 | Biological activity of peanut (Arachis hypogaea) phytoalexins and selected natural and synthetic Stilbenoids. |
| AID1773848 | Inhibition of NLRP3 inflammasome activation in LPS-stimulated mouse J774A.1 cells assessed as inhibition of cell pyrolysis at 20 uM incubated for 1 hr followed by ATP addition and measured after 30 mins by Hoechst 33342/propidium iodide staining based hig | 2021 | Journal of medicinal chemistry, 09-23, Volume: 64, Issue:18 | Discovery of Novel Pterostilbene-Based Derivatives as Potent and Orally Active NLRP3 Inflammasome Inhibitors with Inflammatory Activity for Colitis. |
| AID470666 | Cytotoxicity against mouse B16-BL6 cells after 72 hrs by MTT assay | 2009 | Journal of natural products, Sep, Volume: 72, Issue:9 | Cytotoxic constituents of Soymida febrifuga from Myanmar. |
| AID1352500 | Toxicity in 3 hrs post fertilized zebra fish AB embryo after 93 hrs | 2018 | European journal of medicinal chemistry, Feb-25, Volume: 146 | Alkylated resveratrol prodrugs and metabolites as potential therapeutics for neurodegenerative diseases. |
| AID1371395 | Cytotoxicity against human COLO201 cells assessed as cell viability at 34 uM after 48 hrs by MTT assay | 2017 | Journal of medicinal chemistry, 12-14, Volume: 60, Issue:23 | Polyphenolic Phytochemicals in Cancer Prevention and Therapy: Bioavailability versus Bioefficacy. |
| AID1069496 | Antiinvasion activity in human MDA-MB-231 cells reduction of cell assessed as inhibition of FBS-induced cell invaded to lower surface at 5 uM after 24 hrs | 2014 | Bioorganic & medicinal chemistry letters, Feb-15, Volume: 24, Issue:4 | Urokinase-type plasminogen activator expression and Rac1/WAVE-2/Arp2/3 pathway are blocked by pterostilbene to suppress cell migration and invasion in MDA-MB-231 cells. |
| AID1354540 | Antiinflammatory activity in mouse J774 cells assessed as reduction in LPS-induced nitric oxide production after 24 hrs by Griess assay | 2018 | Journal of natural products, 05-25, Volume: 81, Issue:5 | Natural Stilbenoids Have Anti-Inflammatory Properties in Vivo and Down-Regulate the Production of Inflammatory Mediators NO, IL6, and MCP1 Possibly in a PI3K/Akt-Dependent Manner. |
| AID1183063 | Antifungal activity against Candida famata VKMY-9 assessed as growth inhibition after 48 hrs by broth microdilution method | 2014 | Journal of natural products, Jul-25, Volume: 77, Issue:7 | Antifungal activity of resveratrol derivatives against Candida species. |
| AID1317152 | Oral bioavailability in rat at 56 or 168 mg/kg/day administered through gavage for 14 consecutive days by HPLC analysis | 2016 | European journal of medicinal chemistry, Aug-25, Volume: 119 | How much successful are the medicinal chemists in modulation of SIRT1: A critical review. |
| AID1371375 | Cytotoxicity against human PANC1 cells assessed as decrease in cell viability after 48 hrs by MTT assay | 2017 | Journal of medicinal chemistry, 12-14, Volume: 60, Issue:23 | Polyphenolic Phytochemicals in Cancer Prevention and Therapy: Bioavailability versus Bioefficacy. |
| AID1069486 | Inhibition of Rac1 in human MDA-MB-231 cells at 10 uM after 30 mins by G-LISA activity assay | 2014 | Bioorganic & medicinal chemistry letters, Feb-15, Volume: 24, Issue:4 | Urokinase-type plasminogen activator expression and Rac1/WAVE-2/Arp2/3 pathway are blocked by pterostilbene to suppress cell migration and invasion in MDA-MB-231 cells. |
| AID1083162 | Antifungal activity against Neofusicoccum parvum Bp0014 assessed as growth inhibition measured after 1 to 10 days | 2012 | Journal of agricultural and food chemistry, Dec-05, Volume: 60, Issue:48 | Phenolics and their antifungal role in grapevine wood decay: focus on the Botryosphaeriaceae family. |
| AID1354549 | Antiinflammatory activity in carrageenan induced C57BL/6 mouse model of inflammation assessed as reduction in IL6 expression in hind paw at 30 mg/kg, ip pretreated for 1 to 2 hrs followed by carrageenan challenge measured after 6 hrs by ELISA | 2018 | Journal of natural products, 05-25, Volume: 81, Issue:5 | Natural Stilbenoids Have Anti-Inflammatory Properties in Vivo and Down-Regulate the Production of Inflammatory Mediators NO, IL6, and MCP1 Possibly in a PI3K/Akt-Dependent Manner. |
| AID1309123 | Activation of Nrf2 in mouse MIN6 cells assessed as increase in nuclear Nrf2 translocation by Western blot analysis | 2016 | Bioorganic & medicinal chemistry, 08-15, Volume: 24, Issue:16 | Pterostilbene-mediated Nrf2 activation: Mechanistic insights on Keap1:Nrf2 interface. |
| AID1272523 | Agonist activity at rat TRPA1 expressed in HEK293 cells assessed as induction of intracellular calcium level | 2016 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 26, Issue:3 | TRPA1 channels as targets for resveratrol and related stilbenoids. |
| AID1183061 | Antifungal activity against Candida albicans SC5314 ATCC MYA-2876 assessed as growth inhibition after 48 hrs by broth microdilution method | 2014 | Journal of natural products, Jul-25, Volume: 77, Issue:7 | Antifungal activity of resveratrol derivatives against Candida species. |
| AID1290889 | Antioxidant activity assessed as AAPH scavenging activity assessed as trolox equivalent after 15 mins measured every min for 90 mins by ORAC-FL method relative to control trolox | 2016 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 26, Issue:8 | Pterostilbene-O-acetamidoalkylbenzylamines derivatives as novel dual inhibitors of cholinesterase with anti-β-amyloid aggregation and antioxidant properties for the treatment of Alzheimer's disease. |
| AID667233 | Cytotoxicity against human MCF7 cells after 96 hrs by SRB assay | 2012 | European journal of medicinal chemistry, Aug, Volume: 54 | Synthesis and biological evaluation of novel (E) stilbene-based antitumor agents. |
| AID1238815 | Cytotoxicity against human HT-29 cells assessed as inhibition of cell growth after 24 hrs by MTT assay | 2015 | Journal of medicinal chemistry, Aug-27, Volume: 58, Issue:16 | Novel Resveratrol-Based Aspirin Prodrugs: Synthesis, Metabolism, and Anticancer Activity. |
| AID1083166 | Antifungal activity against Diplodia seriata assessed as growth inhibition measured after 1 to 10 days | 2012 | Journal of agricultural and food chemistry, Dec-05, Volume: 60, Issue:48 | Phenolics and their antifungal role in grapevine wood decay: focus on the Botryosphaeriaceae family. |
| AID1069497 | Antiinvasion activity in human MDA-MB-231 cells reduction of cell assessed as inhibition of FBS-induced cell invaded to lower surface at 2 uM after 24 hrs | 2014 | Bioorganic & medicinal chemistry letters, Feb-15, Volume: 24, Issue:4 | Urokinase-type plasminogen activator expression and Rac1/WAVE-2/Arp2/3 pathway are blocked by pterostilbene to suppress cell migration and invasion in MDA-MB-231 cells. |
| AID1354538 | Inhibition of PI3K/Akt in mouse J774 cells assessed as reduction in LPS-induced Akt phosphorylation at Ser473 after 4 hrs by Western blot analysis | 2018 | Journal of natural products, 05-25, Volume: 81, Issue:5 | Natural Stilbenoids Have Anti-Inflammatory Properties in Vivo and Down-Regulate the Production of Inflammatory Mediators NO, IL6, and MCP1 Possibly in a PI3K/Akt-Dependent Manner. |
| AID1371398 | Cytotoxicity against human BxPC3 cells assessed as cell viability at 34 uM after 48 hrs by MTT assay | 2017 | Journal of medicinal chemistry, 12-14, Volume: 60, Issue:23 | Polyphenolic Phytochemicals in Cancer Prevention and Therapy: Bioavailability versus Bioefficacy. |
| AID470661 | Cytotoxicity against human PANC1 cells in nutrient-deprived condition after 24 hrs by WST8 assay | 2009 | Journal of natural products, Sep, Volume: 72, Issue:9 | Cytotoxic constituents of Soymida febrifuga from Myanmar. |
| AID1371466 | Plasma concentration in mouse at 10 mg/kg, iv at 120 mins by LC-MS/MS method | 2017 | Journal of medicinal chemistry, 12-14, Volume: 60, Issue:23 | Polyphenolic Phytochemicals in Cancer Prevention and Therapy: Bioavailability versus Bioefficacy. |
| AID1674577 | Antimicrobial activity against vancomycin-resistant Staphylococcus aureus 510 after 24 hrs by broth microdilution method | 2020 | Journal of natural products, 08-28, Volume: 83, Issue:8 | Generation of Stilbene Antimicrobials against Multiresistant Strains of |
| AID1898527 | Acute toxicity in po dosed ICR mouse assessed as maximum tolerated dose measured after 7 days | 2021 | Journal of medicinal chemistry, 06-10, Volume: 64, Issue:11 | Discovery of STAT3 and Histone Deacetylase (HDAC) Dual-Pathway Inhibitors for the Treatment of Solid Cancer. |
| AID1773939 | Inhibition of NFkappaB activation in LPS-stimulated mouse bone marrow-derived macrophages assessed as reduction in TNFalpha secretion preincubated for 30 mins followed by nigericin addition and measured after 30 mins by ELISA | 2021 | Journal of medicinal chemistry, 09-23, Volume: 64, Issue:18 | Discovery of Novel Pterostilbene-Based Derivatives as Potent and Orally Active NLRP3 Inflammasome Inhibitors with Inflammatory Activity for Colitis. |
| AID1674579 | Antimicrobial activity against Pseudomonas aeruginosa ATCC 27853 at 256 ug/ml after 24 hrs by broth microdilution assay | 2020 | Journal of natural products, 08-28, Volume: 83, Issue:8 | Generation of Stilbene Antimicrobials against Multiresistant Strains of |
| AID470664 | Cytotoxicity against human HeLa cells after 72 hrs by MTT assay | 2009 | Journal of natural products, Sep, Volume: 72, Issue:9 | Cytotoxic constituents of Soymida febrifuga from Myanmar. |
| AID470663 | Cytotoxicity against human A549 cells after 72 hrs by MTT assay | 2009 | Journal of natural products, Sep, Volume: 72, Issue:9 | Cytotoxic constituents of Soymida febrifuga from Myanmar. |
| AID1069495 | Antiinvasion activity in human MDA-MB-231 cells reduction of cell assessed as inhibition of FBS-induced cell invaded to lower surface at 10 uM after 24 hrs | 2014 | Bioorganic & medicinal chemistry letters, Feb-15, Volume: 24, Issue:4 | Urokinase-type plasminogen activator expression and Rac1/WAVE-2/Arp2/3 pathway are blocked by pterostilbene to suppress cell migration and invasion in MDA-MB-231 cells. |
| AID1069492 | Inhibition of uPA activity in human MDA-MB-231 cells at 5 uM | 2014 | Bioorganic & medicinal chemistry letters, Feb-15, Volume: 24, Issue:4 | Urokinase-type plasminogen activator expression and Rac1/WAVE-2/Arp2/3 pathway are blocked by pterostilbene to suppress cell migration and invasion in MDA-MB-231 cells. |
| AID1069503 | Cytotoxicity against human MDA-MB-231 cells assessed as cell viability at 20 uM after 24 hrs by MTT assay relative to control | 2014 | Bioorganic & medicinal chemistry letters, Feb-15, Volume: 24, Issue:4 | Urokinase-type plasminogen activator expression and Rac1/WAVE-2/Arp2/3 pathway are blocked by pterostilbene to suppress cell migration and invasion in MDA-MB-231 cells. |
| AID1183071 | Antifungal activity against Candida parapsilosis ATCC 22019 assessed as growth inhibition after 48 hrs by broth microdilution method | 2014 | Journal of natural products, Jul-25, Volume: 77, Issue:7 | Antifungal activity of resveratrol derivatives against Candida species. |
| AID1183070 | Antifungal activity against Candida norvegensis clinical isolate assessed as growth inhibition after 48 hrs by broth microdilution method | 2014 | Journal of natural products, Jul-25, Volume: 77, Issue:7 | Antifungal activity of resveratrol derivatives against Candida species. |
| AID1372025 | Antioxidant activity assessed as relative scavenging rate constant for photolysis-induced hydroxyl radical scavenging activity by measuring Kaox/Kst ratio using DMPO spin trap by ESR spectroscopic method | 2017 | Bioorganic & medicinal chemistry letters, 12-01, Volume: 27, Issue:23 | Resveratrol analogues like piceatannol are potent antioxidants as quantitatively demonstrated through the high scavenging ability against reactive oxygen species and methyl radical. |
| AID1371403 | Cytotoxicity against human LN229 cells assessed as cell viability at 34 uM after 48 hrs by MTT assay | 2017 | Journal of medicinal chemistry, 12-14, Volume: 60, Issue:23 | Polyphenolic Phytochemicals in Cancer Prevention and Therapy: Bioavailability versus Bioefficacy. |
| AID1372027 | Antioxidant activity assessed as relative scavenging rate constant for photolysis-induced alkoxyl scavenging activity by measuring Kaox/Kst ratio using DMPO spin trap by ESR spectroscopic method | 2017 | Bioorganic & medicinal chemistry letters, 12-01, Volume: 27, Issue:23 | Resveratrol analogues like piceatannol are potent antioxidants as quantitatively demonstrated through the high scavenging ability against reactive oxygen species and methyl radical. |
| AID1083165 | Antifungal activity against Neofusicoccum parvum assessed as growth inhibition measured after 1 to 10 days | 2012 | Journal of agricultural and food chemistry, Dec-05, Volume: 60, Issue:48 | Phenolics and their antifungal role in grapevine wood decay: focus on the Botryosphaeriaceae family. |
| AID1069502 | Cytotoxicity against human MDA-MB-231 cells assessed as cell viability at 40 uM after 24 hrs by MTT assay relative to control | 2014 | Bioorganic & medicinal chemistry letters, Feb-15, Volume: 24, Issue:4 | Urokinase-type plasminogen activator expression and Rac1/WAVE-2/Arp2/3 pathway are blocked by pterostilbene to suppress cell migration and invasion in MDA-MB-231 cells. |
| AID1507466 | Cytotoxicity against human SH-SY5Y cells assessed as cell survival at 500 uM after 24 hrs by MTT assay relative to control | 2017 | European journal of medicinal chemistry, Aug-18, Volume: 136 | Discovery of efficient stimulators for adult hippocampal neurogenesis based on scaffolds in dragon's blood. |
| AID1272524 | Agonist activity at rat TRPA1 expressed in HEK293 cells assessed as induction of intracellular calcium level relative to allyl isothiocyanate | 2016 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 26, Issue:3 | TRPA1 channels as targets for resveratrol and related stilbenoids. |
| AID1371374 | Cytotoxicity against human BxPC3 cells assessed as decrease in cell viability after 48 hrs by MTT assay | 2017 | Journal of medicinal chemistry, 12-14, Volume: 60, Issue:23 | Polyphenolic Phytochemicals in Cancer Prevention and Therapy: Bioavailability versus Bioefficacy. |
| AID1371453 | Tmax in mouse at 10 mg/kg, iv by LC-MS/MS method | 2017 | Journal of medicinal chemistry, 12-14, Volume: 60, Issue:23 | Polyphenolic Phytochemicals in Cancer Prevention and Therapy: Bioavailability versus Bioefficacy. |
| AID1371368 | Cytotoxicity against human MDA-MB-231 cells assessed as decrease in cell viability after 48 hrs by MTT assay | 2017 | Journal of medicinal chemistry, 12-14, Volume: 60, Issue:23 | Polyphenolic Phytochemicals in Cancer Prevention and Therapy: Bioavailability versus Bioefficacy. |
| AID1069499 | Inhibition of cell migration in human MDA-MB-231 reduction of cell assessed as cells migrated into scratched area at 5 uM after 24 hrs by wound healing assay | 2014 | Bioorganic & medicinal chemistry letters, Feb-15, Volume: 24, Issue:4 | Urokinase-type plasminogen activator expression and Rac1/WAVE-2/Arp2/3 pathway are blocked by pterostilbene to suppress cell migration and invasion in MDA-MB-231 cells. |
| AID320801 | Inhibition of beta amyloid 25-35 fibril formation at 10 uM | 2008 | Bioorganic & medicinal chemistry letters, Jan-15, Volume: 18, Issue:2 | New polyphenols active on beta-amyloid aggregation. |
| AID82982 | In vitro inhibitory concentration against proliferation of HL60 cells | 2003 | Journal of medicinal chemistry, Jul-31, Volume: 46, Issue:16 | Synthesis and biological evaluation of resveratrol and analogues as apoptosis-inducing agents. |
| AID692940 | Cytotoxicity against human SW480 cells at 10 uM for 2 days by vi-cell cell viability analysis | 2011 | Journal of medicinal chemistry, Mar-10, Volume: 54, Issue:5 | Fluorinated N,N-dialkylaminostilbenes for Wnt pathway inhibition and colon cancer repression. |
| AID1898526 | Cytotoxicity against human L02 cells assessed as reduction in cell viability at 32 uM incubated for 48 hrs by MTT assay relative to control | 2021 | Journal of medicinal chemistry, 06-10, Volume: 64, Issue:11 | Discovery of STAT3 and Histone Deacetylase (HDAC) Dual-Pathway Inhibitors for the Treatment of Solid Cancer. |
| AID1552788 | Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS/IFNgamma-induced NO production by measuring NO level preincubated for 2 hrs and followed by LPS/IFNgamma addition and measured after 24 hrs by Griess assay | 2019 | Bioorganic & medicinal chemistry letters, 09-01, Volume: 29, Issue:17 | Comparative analysis of stilbene and benzofuran neolignan derivatives as acetylcholinesterase inhibitors with neuroprotective and anti-inflammatory activities. |
| AID1309125 | Activation of Nrf2 in mouse MIN6 cells assessed as upregulation of human NQO1-ARE-luciferase incubated for 8 hrs by luminometric assay relative to control | 2016 | Bioorganic & medicinal chemistry, 08-15, Volume: 24, Issue:16 | Pterostilbene-mediated Nrf2 activation: Mechanistic insights on Keap1:Nrf2 interface. |
| AID57709 | The concentration causing 50% reduction in the net protein increase (cell growth inhibition, GI50) against central nervous system (CNS) SF-268 cells | 2002 | Journal of medicinal chemistry, Jun-06, Volume: 45, Issue:12 | Antineoplastic agents. 465. Structural modification of resveratrol: sodium resverastatin phosphate. |
| AID1083158 | Antifungal activity against Diplodia seriata PLU03 assessed as growth inhibition measured after 1 to 10 days | 2012 | Journal of agricultural and food chemistry, Dec-05, Volume: 60, Issue:48 | Phenolics and their antifungal role in grapevine wood decay: focus on the Botryosphaeriaceae family. |
| AID1309128 | Inhibition of Nrf2-Keap1 (unknown origin) interaction co-expressed in HEK293T cells using D-luciferin as substrate assessed as decrease in luciferase signal intensity at 0.5 to 10 uM by bioluminescence-based IVIS imaging analysis | 2016 | Bioorganic & medicinal chemistry, 08-15, Volume: 24, Issue:16 | Pterostilbene-mediated Nrf2 activation: Mechanistic insights on Keap1:Nrf2 interface. |
| AID1309124 | Activation of Nrf2 in mouse MIN6 cells assessed as decrease in cytoplasmic Nrf2 fraction by Western blot analysis | 2016 | Bioorganic & medicinal chemistry, 08-15, Volume: 24, Issue:16 | Pterostilbene-mediated Nrf2 activation: Mechanistic insights on Keap1:Nrf2 interface. |
| AID1371400 | Cytotoxicity against human MML1 cells assessed as cell viability at 34 uM after 48 hrs by MTT assay | 2017 | Journal of medicinal chemistry, 12-14, Volume: 60, Issue:23 | Polyphenolic Phytochemicals in Cancer Prevention and Therapy: Bioavailability versus Bioefficacy. |
| AID370920 | Inhibition of COX2 | 2009 | Bioorganic & medicinal chemistry, Feb-01, Volume: 17, Issue:3 | Synthesis and biological evaluation of a library of resveratrol analogues as inhibitors of COX-1, COX-2 and NF-kappaB. |
| AID403245 | Effect on nondiabetic rat assessed as blood glucose level per 100 mL at 20 mg/kg, po | 1997 | Journal of natural products, Jun, Volume: 60, Issue:6 | Antihyperglycemic activity of phenolics from Pterocarpus marsupium. |
| AID1069490 | Inhibition of NF-kappaB activation in human MDA-MB-231 cells after 24 hrs by luciferase assay | 2014 | Bioorganic & medicinal chemistry letters, Feb-15, Volume: 24, Issue:4 | Urokinase-type plasminogen activator expression and Rac1/WAVE-2/Arp2/3 pathway are blocked by pterostilbene to suppress cell migration and invasion in MDA-MB-231 cells. |
| AID692956 | Cytotoxicity against human SW480 cells at 10 uM for 4 days by vi-cell cell viability analysis | 2011 | Journal of medicinal chemistry, Mar-10, Volume: 54, Issue:5 | Fluorinated N,N-dialkylaminostilbenes for Wnt pathway inhibition and colon cancer repression. |
| AID1069500 | Inhibition of cell migration in human MDA-MB-231 cells reduction of cell assessed as cells migrated into scratched area at 2 uM after 24 hrs by wound healing assay | 2014 | Bioorganic & medicinal chemistry letters, Feb-15, Volume: 24, Issue:4 | Urokinase-type plasminogen activator expression and Rac1/WAVE-2/Arp2/3 pathway are blocked by pterostilbene to suppress cell migration and invasion in MDA-MB-231 cells. |
| AID1371378 | Cytotoxicity against human U87 cells assessed as decrease in cell viability after 48 hrs by MTT assay | 2017 | Journal of medicinal chemistry, 12-14, Volume: 60, Issue:23 | Polyphenolic Phytochemicals in Cancer Prevention and Therapy: Bioavailability versus Bioefficacy. |
| AID1371455 | Plasma concentration in mouse at 10 mg/kg, iv at 60 mins by LC-MS/MS method | 2017 | Journal of medicinal chemistry, 12-14, Volume: 60, Issue:23 | Polyphenolic Phytochemicals in Cancer Prevention and Therapy: Bioavailability versus Bioefficacy. |
| AID1371379 | Cytotoxicity against human LN229 cells assessed as decrease in cell viability after 48 hrs by MTT assay | 2017 | Journal of medicinal chemistry, 12-14, Volume: 60, Issue:23 | Polyphenolic Phytochemicals in Cancer Prevention and Therapy: Bioavailability versus Bioefficacy. |
| AID1371392 | Cytotoxicity against human MDA-MB-231 cells assessed as cell viability at 34 uM after 48 hrs by MTT assay | 2017 | Journal of medicinal chemistry, 12-14, Volume: 60, Issue:23 | Polyphenolic Phytochemicals in Cancer Prevention and Therapy: Bioavailability versus Bioefficacy. |
| AID1272526 | Antagonist activity at human TRPV1 expressed in HEK293 cells assessed as inhibition of allyl isothiocyanate-induced increase of intracellular calcium level | 2016 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 26, Issue:3 | TRPA1 channels as targets for resveratrol and related stilbenoids. |
| AID667229 | Cytotoxicity against human A549 cells after 96 hrs by SRB assay | 2012 | European journal of medicinal chemistry, Aug, Volume: 54 | Synthesis and biological evaluation of novel (E) stilbene-based antitumor agents. |
| AID82976 | In vitro concentration required to induce apoptosis in HL60 cells | 2003 | Journal of medicinal chemistry, Jul-31, Volume: 46, Issue:16 | Synthesis and biological evaluation of resveratrol and analogues as apoptosis-inducing agents. |
| AID1354542 | Antiinflammatory activity in mouse J774 cells assessed as reduction in LPS-induced MCP1 expression after 24 hrs by ELISA | 2018 | Journal of natural products, 05-25, Volume: 81, Issue:5 | Natural Stilbenoids Have Anti-Inflammatory Properties in Vivo and Down-Regulate the Production of Inflammatory Mediators NO, IL6, and MCP1 Possibly in a PI3K/Akt-Dependent Manner. |
| AID1069501 | Cytotoxicity against human MDA-MB-231 cells assessed as cell viability up to 10 uM after 24 hrs by MTT assay relative to control | 2014 | Bioorganic & medicinal chemistry letters, Feb-15, Volume: 24, Issue:4 | Urokinase-type plasminogen activator expression and Rac1/WAVE-2/Arp2/3 pathway are blocked by pterostilbene to suppress cell migration and invasion in MDA-MB-231 cells. |
| AID1898495 | Cytotoxicity against human HCT-116 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay | 2021 | Journal of medicinal chemistry, 06-10, Volume: 64, Issue:11 | Discovery of STAT3 and Histone Deacetylase (HDAC) Dual-Pathway Inhibitors for the Treatment of Solid Cancer. |
| AID1354546 | Antiinflammatory activity in carrageenan induced C57BL/6 mouse model of inflammation assessed as reduction in paw edema at 30 mg/kg, ip pretreated for 1 to 2 hrs followed by carrageenan challenge measured after 3 to 6 hrs by plethysmometer | 2018 | Journal of natural products, 05-25, Volume: 81, Issue:5 | Natural Stilbenoids Have Anti-Inflammatory Properties in Vivo and Down-Regulate the Production of Inflammatory Mediators NO, IL6, and MCP1 Possibly in a PI3K/Akt-Dependent Manner. |
| AID510868 | Cytotoxicity against human HT-29 cells after 3 days by [3H]thymidine incorporation assay | 2010 | European journal of medicinal chemistry, Sep, Volume: 45, Issue:9 | In vitro and in vivo studies on stilbene analogs as potential treatment agents for colon cancer. |
| AID1371376 | Cytotoxicity against human MML1 cells assessed as decrease in cell viability after 48 hrs by MTT assay | 2017 | Journal of medicinal chemistry, 12-14, Volume: 60, Issue:23 | Polyphenolic Phytochemicals in Cancer Prevention and Therapy: Bioavailability versus Bioefficacy. |
| AID1083170 | Antifungal activity against Diplodia seriata assessed as growth inhibition at 500 uM measured after 1 to 10 days relative to control | 2012 | Journal of agricultural and food chemistry, Dec-05, Volume: 60, Issue:48 | Phenolics and their antifungal role in grapevine wood decay: focus on the Botryosphaeriaceae family. |
| AID1083159 | Antifungal activity against Diplodia mutila BRA08 assessed as growth inhibition measured after 1 to 10 days | 2012 | Journal of agricultural and food chemistry, Dec-05, Volume: 60, Issue:48 | Phenolics and their antifungal role in grapevine wood decay: focus on the Botryosphaeriaceae family. |
| AID1773849 | Cytotoxicity against human L-02 cells incubated for 24 hrs by MTT assay | 2021 | Journal of medicinal chemistry, 09-23, Volume: 64, Issue:18 | Discovery of Novel Pterostilbene-Based Derivatives as Potent and Orally Active NLRP3 Inflammasome Inhibitors with Inflammatory Activity for Colitis. |
| AID492062 | Inhibition of human aromatase preincubated with NADP+ for 10 mins before substrate addition measured after 30 mins | 2010 | Bioorganic & medicinal chemistry, Jul-15, Volume: 18, Issue:14 | Design, synthesis, and biological evaluation of resveratrol analogues as aromatase and quinone reductase 2 inhibitors for chemoprevention of cancer. |
| AID692943 | Cytotoxicity against human LS 174T cells at 10 uM for 4 days by vi-cell cell viability analysis | 2011 | Journal of medicinal chemistry, Mar-10, Volume: 54, Issue:5 | Fluorinated N,N-dialkylaminostilbenes for Wnt pathway inhibition and colon cancer repression. |
| AID1371369 | Cytotoxicity against human T47D cells assessed as decrease in cell viability after 48 hrs by MTT assay | 2017 | Journal of medicinal chemistry, 12-14, Volume: 60, Issue:23 | Polyphenolic Phytochemicals in Cancer Prevention and Therapy: Bioavailability versus Bioefficacy. |
| AID1371401 | Cytotoxicity against human SK-MEL-2 cells assessed as cell viability at 34 uM after 48 hrs by MTT assay | 2017 | Journal of medicinal chemistry, 12-14, Volume: 60, Issue:23 | Polyphenolic Phytochemicals in Cancer Prevention and Therapy: Bioavailability versus Bioefficacy. |
| AID1847356 | Oral bioavailability in BALB/c mouse relative to control | 2021 | European journal of medicinal chemistry, Nov-05, Volume: 223 | Recent research and development of NDM-1 inhibitors. |
| AID1372021 | Antioxidant activity assessed as Trolox equivalents of photolysis-induced alkoxyl scavenging activity using DMPO spin trap by ESR spectroscopic method | 2017 | Bioorganic & medicinal chemistry letters, 12-01, Volume: 27, Issue:23 | Resveratrol analogues like piceatannol are potent antioxidants as quantitatively demonstrated through the high scavenging ability against reactive oxygen species and methyl radical. |
| AID1183067 | Antifungal activity against Candida kefyr clinical isolate assessed as growth inhibition after 48 hrs by broth microdilution method | 2014 | Journal of natural products, Jul-25, Volume: 77, Issue:7 | Antifungal activity of resveratrol derivatives against Candida species. |
| AID370919 | Inhibition of COX1 | 2009 | Bioorganic & medicinal chemistry, Feb-01, Volume: 17, Issue:3 | Synthesis and biological evaluation of a library of resveratrol analogues as inhibitors of COX-1, COX-2 and NF-kappaB. |
| AID1371399 | Cytotoxicity against human PANC1 cells assessed as cell viability at 34 uM after 48 hrs by MTT assay | 2017 | Journal of medicinal chemistry, 12-14, Volume: 60, Issue:23 | Polyphenolic Phytochemicals in Cancer Prevention and Therapy: Bioavailability versus Bioefficacy. |
| AID667226 | Cytotoxicity against human 518A2 cells after 96 hrs by SRB assay | 2012 | European journal of medicinal chemistry, Aug, Volume: 54 | Synthesis and biological evaluation of novel (E) stilbene-based antitumor agents. |
| AID1847355 | Inhibition of NDM-1 (unknown origin) by using nitrocefin as substrate preincubated for 10 min followed by nitrocefin addition incubated after 30 min | 2021 | European journal of medicinal chemistry, Nov-05, Volume: 223 | Recent research and development of NDM-1 inhibitors. |
| AID614082 | Antibacterial activity against Enterobacter dissolvens ATCC 222 at 10 mg/ml after 24 to 72 hrs by agar diffusion method | 2011 | Bioorganic & medicinal chemistry, Sep-01, Volume: 19, Issue:17 | Synthesis and antimicrobial activity of (E) stilbene derivatives. |
| AID1371377 | Cytotoxicity against human SK-MEL-2 cells assessed as decrease in cell viability after 48 hrs by MTT assay | 2017 | Journal of medicinal chemistry, 12-14, Volume: 60, Issue:23 | Polyphenolic Phytochemicals in Cancer Prevention and Therapy: Bioavailability versus Bioefficacy. |
| AID1290887 | Inhibition of rat serum butyrylcholinesterase using butyrylthiocholine iodide substrate after 15 mins by spectrophotometric method | 2016 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 26, Issue:8 | Pterostilbene-O-acetamidoalkylbenzylamines derivatives as novel dual inhibitors of cholinesterase with anti-β-amyloid aggregation and antioxidant properties for the treatment of Alzheimer's disease. |
| AID1371461 | Cytotoxicity against human HT-29 cells assessed as decrease in cell viability at 20 uM after 48 hrs by SRB method relative to control | 2017 | Journal of medicinal chemistry, 12-14, Volume: 60, Issue:23 | Polyphenolic Phytochemicals in Cancer Prevention and Therapy: Bioavailability versus Bioefficacy. |
| AID1371371 | Cytotoxicity against human COLO201 cells assessed as decrease in cell viability after 48 hrs by MTT assay | 2017 | Journal of medicinal chemistry, 12-14, Volume: 60, Issue:23 | Polyphenolic Phytochemicals in Cancer Prevention and Therapy: Bioavailability versus Bioefficacy. |
| AID1372023 | Antioxidant activity assessed as Trolox equivalents of photolysis-induced superoxide anion scavenging activity using CYPMPO spin trap by ESR spectroscopic method | 2017 | Bioorganic & medicinal chemistry letters, 12-01, Volume: 27, Issue:23 | Resveratrol analogues like piceatannol are potent antioxidants as quantitatively demonstrated through the high scavenging ability against reactive oxygen species and methyl radical. |
| AID1371459 | Cytotoxicity against human A375 cells assessed as decrease in cell viability at 20 uM after 48 hrs by SRB method relative to control | 2017 | Journal of medicinal chemistry, 12-14, Volume: 60, Issue:23 | Polyphenolic Phytochemicals in Cancer Prevention and Therapy: Bioavailability versus Bioefficacy. |
| AID1069487 | Inhibition of Rac1 in human MDA-MB-231 cells at 5 uM after 30 mins by G-LISA activity assay | 2014 | Bioorganic & medicinal chemistry letters, Feb-15, Volume: 24, Issue:4 | Urokinase-type plasminogen activator expression and Rac1/WAVE-2/Arp2/3 pathway are blocked by pterostilbene to suppress cell migration and invasion in MDA-MB-231 cells. |
| AID1898497 | Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay | 2021 | Journal of medicinal chemistry, 06-10, Volume: 64, Issue:11 | Discovery of STAT3 and Histone Deacetylase (HDAC) Dual-Pathway Inhibitors for the Treatment of Solid Cancer. |
| AID264588 | Antiproliferative activity against human HL60 cell line | 2006 | Journal of medicinal chemistry, May-18, Volume: 49, Issue:10 | Identification of a terphenyl derivative that blocks the cell cycle in the G0-G1 phase and induces differentiation in leukemia cells. |
| AID1256166 | Inhibition of Quorum sensing system in Chromobacterium violaceum CV026 after 24 hrs by agar-well diffusion method | 2015 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 25, Issue:22 | The quorum-sensing inhibiting effects of stilbenoids and their potential structure-activity relationship. |
| AID1440407 | Antifungal activity against Candida albicans by broth dilution assay | 2017 | Journal of medicinal chemistry, 03-23, Volume: 60, Issue:6 | Tackling Fungal Resistance by Biofilm Inhibitors. |
| AID1372024 | Antioxidant activity assessed as Trolox equivalents of photolysis-induced singlet oxygen scavenging activity using 4-HO-TEMP spin trap by ESR spectroscopic method | 2017 | Bioorganic & medicinal chemistry letters, 12-01, Volume: 27, Issue:23 | Resveratrol analogues like piceatannol are potent antioxidants as quantitatively demonstrated through the high scavenging ability against reactive oxygen species and methyl radical. |
| AID1081915 | Antifungal activity against Phomopsis obscurans assessed as growth inhibition at 30 uM after 144 hr by NCCLS M27-A broth microdilution method | 2011 | Journal of agricultural and food chemistry, Mar-09, Volume: 59, Issue:5 | Biological activity of peanut (Arachis hypogaea) phytoalexins and selected natural and synthetic Stilbenoids. |
| AID1570236 | Inhibition of human 5-LOX expressed in Escherichia coli BL21 using arachidonic acid as substrate preincubated for 15 mins followed by substrate addition by HPLC analysis | 2019 | European journal of medicinal chemistry, Oct-15, Volume: 180 | Protective effect of piceatannol and bioactive stilbene derivatives against hypoxia-induced toxicity in H9c2 cardiomyocytes and structural elucidation as 5-LOX inhibitors. |
| AID1083156 | Antifungal activity against Diplodia seriata LAT28 assessed as growth inhibition measured after 1 to 10 days | 2012 | Journal of agricultural and food chemistry, Dec-05, Volume: 60, Issue:48 | Phenolics and their antifungal role in grapevine wood decay: focus on the Botryosphaeriaceae family. |
| AID1371454 | Plasma concentration in mouse at 100 mg/kg, po at 60 mins by LC-MS/MS method | 2017 | Journal of medicinal chemistry, 12-14, Volume: 60, Issue:23 | Polyphenolic Phytochemicals in Cancer Prevention and Therapy: Bioavailability versus Bioefficacy. |
| AID470665 | Cytotoxicity against mouse Colon 26-L5 cells after 72 hrs by MTT assay | 2009 | Journal of natural products, Sep, Volume: 72, Issue:9 | Cytotoxic constituents of Soymida febrifuga from Myanmar. |
| AID1773851 | Inhibition of NLRP3 inflammasome activation in LPS-stimulated mouse bone marrow-derived macrophages assessed as reduction in IL-1beta secretion preincubated for 30 mins followed by nigericin addition and measured after 30 mins by ELISA | 2021 | Journal of medicinal chemistry, 09-23, Volume: 64, Issue:18 | Discovery of Novel Pterostilbene-Based Derivatives as Potent and Orally Active NLRP3 Inflammasome Inhibitors with Inflammatory Activity for Colitis. |
| AID1183075 | Antifungal activity against Candida albicans SC5314 ATCC MYA-2876 assessed as inhibition of hyphal formation at 14 ug/ml after 48 hrs by microscopy | 2014 | Journal of natural products, Jul-25, Volume: 77, Issue:7 | Antifungal activity of resveratrol derivatives against Candida species. |
| AID1371370 | Cytotoxicity against human HT-29 cells assessed as decrease in cell viability after 48 hrs by MTT assay | 2017 | Journal of medicinal chemistry, 12-14, Volume: 60, Issue:23 | Polyphenolic Phytochemicals in Cancer Prevention and Therapy: Bioavailability versus Bioefficacy. |
| AID1309127 | Inhibition of Nrf2-Keap1 (unknown origin) interaction co-expressed in HEK293T cells using D-luciferin as substrate assessed as decrease in luciferase signal intensity incubated for 24 hrs by bioluminescence-based IVIS imaging analysis | 2016 | Bioorganic & medicinal chemistry, 08-15, Volume: 24, Issue:16 | Pterostilbene-mediated Nrf2 activation: Mechanistic insights on Keap1:Nrf2 interface. |
| AID492060 | Inhibition of human aromatase at 20 ug/ml preincubated with NADP+ for 10 mins before substrate addition measured after 30 mins | 2010 | Bioorganic & medicinal chemistry, Jul-15, Volume: 18, Issue:14 | Design, synthesis, and biological evaluation of resveratrol analogues as aromatase and quinone reductase 2 inhibitors for chemoprevention of cancer. |
| AID264592 | Antiproliferative activity against human K562 cell line expressing Bcr-Abl | 2006 | Journal of medicinal chemistry, May-18, Volume: 49, Issue:10 | Identification of a terphenyl derivative that blocks the cell cycle in the G0-G1 phase and induces differentiation in leukemia cells. |
| AID40024 | In vitro growth inhibition of BXPC-3 (human pancreatic adenocarcinoma) cell line. | 2002 | Journal of medicinal chemistry, Jun-06, Volume: 45, Issue:12 | Antineoplastic agents. 465. Structural modification of resveratrol: sodium resverastatin phosphate. |
| AID1069493 | Down-regulation of uPAR mRNA expression in human MDA-MB-231 cells at 2 to 10 uM after 24 hrs by RT-PCR analysis | 2014 | Bioorganic & medicinal chemistry letters, Feb-15, Volume: 24, Issue:4 | Urokinase-type plasminogen activator expression and Rac1/WAVE-2/Arp2/3 pathway are blocked by pterostilbene to suppress cell migration and invasion in MDA-MB-231 cells. |
| AID1507467 | Cytotoxicity against human SH-SY5Y cells assessed as cell survival at 1000 uM after 24 hrs by MTT assay relative to control | 2017 | European journal of medicinal chemistry, Aug-18, Volume: 136 | Discovery of efficient stimulators for adult hippocampal neurogenesis based on scaffolds in dragon's blood. |
| AID1372029 | Antioxidant activity assessed as relative scavenging rate constant for photolysis-induced super-oxide anion scavenging activity by measuring Kaox/Kst ratio using CYPMPO spin trap by ESR spectroscopic method | 2017 | Bioorganic & medicinal chemistry letters, 12-01, Volume: 27, Issue:23 | Resveratrol analogues like piceatannol are potent antioxidants as quantitatively demonstrated through the high scavenging ability against reactive oxygen species and methyl radical. |
| AID1272522 | Antagonist activity at rat TRPA1 expressed in HEK293 cells assessed as inhibition of allyl isothiocyanate-induced increase of intracellular calcium level | 2016 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 26, Issue:3 | TRPA1 channels as targets for resveratrol and related stilbenoids. |
| AID1570233 | Cytoprotective activity against hypoxia-induced toxicity rat H9c2 cells assessed as increase in cell viability at 80 nM preincubated for 18 hrs followed by incubated in hypoxia for 48 hrs by MTT assay | 2019 | European journal of medicinal chemistry, Oct-15, Volume: 180 | Protective effect of piceatannol and bioactive stilbene derivatives against hypoxia-induced toxicity in H9c2 cardiomyocytes and structural elucidation as 5-LOX inhibitors. |
| AID1083163 | Antifungal activity against Botryosphaeria dothidea OGE14 assessed as growth inhibition measured after 1 to 10 days relative to control | 2012 | Journal of agricultural and food chemistry, Dec-05, Volume: 60, Issue:48 | Phenolics and their antifungal role in grapevine wood decay: focus on the Botryosphaeriaceae family. |
| AID614089 | Cytotoxicity against mouse NIH/3T3 cells after 96 hrs by sulforhodamine-B colorimetric assay | 2011 | Bioorganic & medicinal chemistry, Sep-01, Volume: 19, Issue:17 | Synthesis and antimicrobial activity of (E) stilbene derivatives. |
| AID1898525 | Cytotoxicity against human MCF-10 A cells assessed as reduction in cell viability at 32 uM incubated for 48 hrs by MTT assay relative to control | 2021 | Journal of medicinal chemistry, 06-10, Volume: 64, Issue:11 | Discovery of STAT3 and Histone Deacetylase (HDAC) Dual-Pathway Inhibitors for the Treatment of Solid Cancer. |
| AID1570235 | Cytoprotective activity against hypoxia-induced apoptosis in rat H9c2 cells assessed as early apoptotic cells at 2 uM preincubated for 18 hrs followed by incubated in hypoxia for 48 hrs by annexin V based flow cytometry (Rvb = 60 %) | 2019 | European journal of medicinal chemistry, Oct-15, Volume: 180 | Protective effect of piceatannol and bioactive stilbene derivatives against hypoxia-induced toxicity in H9c2 cardiomyocytes and structural elucidation as 5-LOX inhibitors. |
| AID667228 | Cytotoxicity against human A253 cells after 96 hrs by SRB assay | 2012 | European journal of medicinal chemistry, Aug, Volume: 54 | Synthesis and biological evaluation of novel (E) stilbene-based antitumor agents. |
| AID103219 | Cell growth inhibition of breast MCF-7 cells, expressed as 50% reduction in the net protein increase | 2002 | Journal of medicinal chemistry, Jun-06, Volume: 45, Issue:12 | Antineoplastic agents. 465. Structural modification of resveratrol: sodium resverastatin phosphate. |
| AID1081919 | Octanol-water partition coefficient, log P of the compound by HPLC analysis | 2011 | Journal of agricultural and food chemistry, Mar-09, Volume: 59, Issue:5 | Biological activity of peanut (Arachis hypogaea) phytoalexins and selected natural and synthetic Stilbenoids. |
| AID1069491 | Inhibition of uPA activity in human MDA-MB-231 cells at 10 uM | 2014 | Bioorganic & medicinal chemistry letters, Feb-15, Volume: 24, Issue:4 | Urokinase-type plasminogen activator expression and Rac1/WAVE-2/Arp2/3 pathway are blocked by pterostilbene to suppress cell migration and invasion in MDA-MB-231 cells. |
| AID1083171 | Antifungal activity against Togninia minima SO21 assessed as susceptibility at 500 uM measured after 1 to 10 days | 2012 | Journal of agricultural and food chemistry, Dec-05, Volume: 60, Issue:48 | Phenolics and their antifungal role in grapevine wood decay: focus on the Botryosphaeriaceae family. |
| AID1372026 | Antioxidant activity assessed as relative scavenging rate constant for photolysis-induced methyl radical scavenging activity by measuring Kaox/Kst ratio using DMPO spin trap by ESR spectroscopic method | 2017 | Bioorganic & medicinal chemistry letters, 12-01, Volume: 27, Issue:23 | Resveratrol analogues like piceatannol are potent antioxidants as quantitatively demonstrated through the high scavenging ability against reactive oxygen species and methyl radical. |
| AID1083152 | Antifungal activity against Diplodia seriata assessed as mycelium seemed to be halted measured after 2 days environmental scanning electron microscopy | 2012 | Journal of agricultural and food chemistry, Dec-05, Volume: 60, Issue:48 | Phenolics and their antifungal role in grapevine wood decay: focus on the Botryosphaeriaceae family. |
| AID1674578 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus ATCC 33591 after 24 hrs by broth microdilution method | 2020 | Journal of natural products, 08-28, Volume: 83, Issue:8 | Generation of Stilbene Antimicrobials against Multiresistant Strains of |
| AID1083161 | Antifungal activity against Neofusicoccum parvum PER20 assessed as growth inhibition measured after 1 to 10 days | 2012 | Journal of agricultural and food chemistry, Dec-05, Volume: 60, Issue:48 | Phenolics and their antifungal role in grapevine wood decay: focus on the Botryosphaeriaceae family. |
| AID1372020 | Antioxidant activity assessed as Trolox equivalents of photolysis-induced methyl radical scavenging activity using DMPO spin trap by ESR spectroscopic method | 2017 | Bioorganic & medicinal chemistry letters, 12-01, Volume: 27, Issue:23 | Resveratrol analogues like piceatannol are potent antioxidants as quantitatively demonstrated through the high scavenging ability against reactive oxygen species and methyl radical. |
| AID1507472 | In vivo neurogenic activity in Sprague-Dawley rat neural progenitor cells at 4 mg/kg, ip qd pretreated for 28 days followed by BrdU addition at 2 hrs interval for twice on day 29 measured after 24 hrs by BrdU incorporation assay relative to control | 2017 | European journal of medicinal chemistry, Aug-18, Volume: 136 | Discovery of efficient stimulators for adult hippocampal neurogenesis based on scaffolds in dragon's blood. |
| AID1371462 | Cytotoxicity against human MCF7 cells assessed as decrease in cell viability at 20 uM after 48 hrs by SRB method relative to control | 2017 | Journal of medicinal chemistry, 12-14, Volume: 60, Issue:23 | Polyphenolic Phytochemicals in Cancer Prevention and Therapy: Bioavailability versus Bioefficacy. |
| AID264590 | Antiproliferative activity against MDR human HL60R cell line | 2006 | Journal of medicinal chemistry, May-18, Volume: 49, Issue:10 | Identification of a terphenyl derivative that blocks the cell cycle in the G0-G1 phase and induces differentiation in leukemia cells. |
| AID1083157 | Antifungal activity against Lasiodiplodia theobromae CBS116460 assessed as growth inhibition measured after 1 to 10 days | 2012 | Journal of agricultural and food chemistry, Dec-05, Volume: 60, Issue:48 | Phenolics and their antifungal role in grapevine wood decay: focus on the Botryosphaeriaceae family. |
| AID770333 | Inhibition of human quinone reductase 2 expressed in Escherichia coli BL21(DE3) using N-methyldihydronicotinamide as co-substrate | 2013 | Bioorganic & medicinal chemistry, Oct-01, Volume: 21, Issue:19 | Design, synthesis, biological and structural evaluation of functionalized resveratrol analogues as inhibitors of quinone reductase 2. |
| AID1070113 | Allosteric modulation of rat GABAA alpha1beta2gamma2S receptor expressed in Xenopus laevis oocytes assessed as potentiation of GABA-induced chloride ion current at holding potential -70 mV at 100 uM by two-microelectrode voltage clamp assay relative to GA | 2014 | Bioorganic & medicinal chemistry, Feb-15, Volume: 22, Issue:4 | Identification of dihydrostilbenes in Pholidota chinensis as a new scaffold for GABAA receptor modulators. |
| AID1069498 | Inhibition of cell migration in human MDA-MB-231 cells assessed as reduction of cell migrated into scratched area at 10 uM after 24 hrs by wound healing assay | 2014 | Bioorganic & medicinal chemistry letters, Feb-15, Volume: 24, Issue:4 | Urokinase-type plasminogen activator expression and Rac1/WAVE-2/Arp2/3 pathway are blocked by pterostilbene to suppress cell migration and invasion in MDA-MB-231 cells. |
| AID614080 | Antibacterial activity against Bacillus brevis ATTC 9999 at 10 mg/ml after 24 to 72 hrs by agar diffusion method | 2011 | Bioorganic & medicinal chemistry, Sep-01, Volume: 19, Issue:17 | Synthesis and antimicrobial activity of (E) stilbene derivatives. |
| AID1083169 | Antifungal activity against Neofusicoccum parvum assessed as growth inhibition at 500 uM measured after 1 to 10 days relative to control | 2012 | Journal of agricultural and food chemistry, Dec-05, Volume: 60, Issue:48 | Phenolics and their antifungal role in grapevine wood decay: focus on the Botryosphaeriaceae family. |
| AID1372028 | Antioxidant activity assessed as relative scavenging rate constant for photolysis-induced peroxyl scavenging activity by measuring Kaox/Kst ratio using CYPMPO spin trap by ESR spectroscopic method | 2017 | Bioorganic & medicinal chemistry letters, 12-01, Volume: 27, Issue:23 | Resveratrol analogues like piceatannol are potent antioxidants as quantitatively demonstrated through the high scavenging ability against reactive oxygen species and methyl radical. |
| AID1372030 | Antioxidant activity assessed as relative scavenging rate constant for photolysis-induced singlet oxygen scavenging activity by measuring Kaox/Kst ratio using 4-HO-TEMP spin trap by ESR spectroscopic method | 2017 | Bioorganic & medicinal chemistry letters, 12-01, Volume: 27, Issue:23 | Resveratrol analogues like piceatannol are potent antioxidants as quantitatively demonstrated through the high scavenging ability against reactive oxygen species and methyl radical. |
| AID1704238 | Antibacterial activity against Methicillin-resistant Staphylococcus aureus ATCC 33591 incubated for 20 hrs by broth two-fold dilution method | 2020 | European journal of medicinal chemistry, Nov-15, Volume: 206 | 1,2,3-Triazole-containing hybrids with potential antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA). |
| AID692942 | Cytotoxicity against human HCT116 cells at 10 uM for 4 days by vi-cell cell viability analysis | 2011 | Journal of medicinal chemistry, Mar-10, Volume: 54, Issue:5 | Fluorinated N,N-dialkylaminostilbenes for Wnt pathway inhibition and colon cancer repression. |
| AID1183066 | Antifungal activity against Candida inconspicua clinical isolate assessed as growth inhibition after 48 hrs by broth microdilution method | 2014 | Journal of natural products, Jul-25, Volume: 77, Issue:7 | Antifungal activity of resveratrol derivatives against Candida species. |
| AID1069485 | Inhibition of Rac1-mediated WAVE-2/Arp2/3 expression in human MDA-MB-231 cells after 24 mins by Western blotting analysis | 2014 | Bioorganic & medicinal chemistry letters, Feb-15, Volume: 24, Issue:4 | Urokinase-type plasminogen activator expression and Rac1/WAVE-2/Arp2/3 pathway are blocked by pterostilbene to suppress cell migration and invasion in MDA-MB-231 cells. |
| AID1371397 | Cytotoxicity against human NCI-H460 cells assessed as cell viability at 34 uM after 48 hrs by MTT assay | 2017 | Journal of medicinal chemistry, 12-14, Volume: 60, Issue:23 | Polyphenolic Phytochemicals in Cancer Prevention and Therapy: Bioavailability versus Bioefficacy. |
| AID667232 | Cytotoxicity against human Lipo cells after 96 hrs by SRB assay | 2012 | European journal of medicinal chemistry, Aug, Volume: 54 | Synthesis and biological evaluation of novel (E) stilbene-based antitumor agents. |
| AID255902 | Inhibitory concentration required for antiproliferative activity against human MDA-MB-231 cells | 2005 | Journal of medicinal chemistry, Nov-03, Volume: 48, Issue:22 | Synthesis of a resveratrol analogue with high ceramide-mediated proapoptotic activity on human breast cancer cells. |
| AID667227 | Cytotoxicity against human 850C cells after 96 hrs by SRB assay | 2012 | European journal of medicinal chemistry, Aug, Volume: 54 | Synthesis and biological evaluation of novel (E) stilbene-based antitumor agents. |
| AID482994 | Inhibition of amyloid beta 25-35 fibril formation at 10 uM by using UV-visible measurements and electron microscopy analysis | 2010 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 20, Issue:11 | New stilbene dimers against amyloid fibril formation. |
| AID667231 | Cytotoxicity against human DLD1 cells after 96 hrs by SRB assay | 2012 | European journal of medicinal chemistry, Aug, Volume: 54 | Synthesis and biological evaluation of novel (E) stilbene-based antitumor agents. |
| AID1371396 | Cytotoxicity against human A549 cells assessed as cell viability at 34 uM after 48 hrs by MTT assay | 2017 | Journal of medicinal chemistry, 12-14, Volume: 60, Issue:23 | Polyphenolic Phytochemicals in Cancer Prevention and Therapy: Bioavailability versus Bioefficacy. |
| AID1081911 | Antifungal activity against Botryotinia fuckeliana assessed as growth inhibition after 72 hr by NCCLS M27-A broth microdilution method | 2011 | Journal of agricultural and food chemistry, Mar-09, Volume: 59, Issue:5 | Biological activity of peanut (Arachis hypogaea) phytoalexins and selected natural and synthetic Stilbenoids. |
| AID1371457 | Tmax in mouse at 100 mg/kg, po by HPLC method | 2017 | Journal of medicinal chemistry, 12-14, Volume: 60, Issue:23 | Polyphenolic Phytochemicals in Cancer Prevention and Therapy: Bioavailability versus Bioefficacy. |
| AID1371460 | Cytotoxicity against human A549 cells assessed as decrease in cell viability at 20 uM after 48 hrs by SRB method relative to control | 2017 | Journal of medicinal chemistry, 12-14, Volume: 60, Issue:23 | Polyphenolic Phytochemicals in Cancer Prevention and Therapy: Bioavailability versus Bioefficacy. |
| AID1372022 | Antioxidant activity assessed as Trolox equivalents of photolysis-induced peroxyl scavenging activity using CYPMPO spin trap by ESR spectroscopic method | 2017 | Bioorganic & medicinal chemistry letters, 12-01, Volume: 27, Issue:23 | Resveratrol analogues like piceatannol are potent antioxidants as quantitatively demonstrated through the high scavenging ability against reactive oxygen species and methyl radical. |
| AID1069494 | Down-regulation of uPA mRNA expression in human MDA-MB-231 cells after 24 hrs by RT-PCR analysis | 2014 | Bioorganic & medicinal chemistry letters, Feb-15, Volume: 24, Issue:4 | Urokinase-type plasminogen activator expression and Rac1/WAVE-2/Arp2/3 pathway are blocked by pterostilbene to suppress cell migration and invasion in MDA-MB-231 cells. |
| AID264593 | Proapoptotic activity against human K562 cell line expressing Bcr-Abl | 2006 | Journal of medicinal chemistry, May-18, Volume: 49, Issue:10 | Identification of a terphenyl derivative that blocks the cell cycle in the G0-G1 phase and induces differentiation in leukemia cells. |
| AID403247 | Decrease in body weight in nondiabetic rat | 1997 | Journal of natural products, Jun, Volume: 60, Issue:6 | Antihyperglycemic activity of phenolics from Pterocarpus marsupium. |
| AID1183072 | Antifungal activity against Candida tropicalis ATCC MYA-3404/T1 assessed as growth inhibition after 48 hrs by broth microdilution method | 2014 | Journal of natural products, Jul-25, Volume: 77, Issue:7 | Antifungal activity of resveratrol derivatives against Candida species. |
| AID1704239 | Bactericidal activity against methicillin-resistant Staphylococcus aureus ATCC 33591 measured after 20 hrs | 2020 | European journal of medicinal chemistry, Nov-15, Volume: 206 | 1,2,3-Triazole-containing hybrids with potential antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA). |
| AID470662 | Cytotoxicity against human HT1080 cells after 72 hrs by MTT assay | 2009 | Journal of natural products, Sep, Volume: 72, Issue:9 | Cytotoxic constituents of Soymida febrifuga from Myanmar. |
| AID94870 | In vitro growth inhibition of KM20L2 cell line. | 2002 | Journal of medicinal chemistry, Jun-06, Volume: 45, Issue:12 | Antineoplastic agents. 465. Structural modification of resveratrol: sodium resverastatin phosphate. |
| AID1371394 | Cytotoxicity against human HT-29 cells assessed as cell viability at 34 uM after 48 hrs by MTT assay | 2017 | Journal of medicinal chemistry, 12-14, Volume: 60, Issue:23 | Polyphenolic Phytochemicals in Cancer Prevention and Therapy: Bioavailability versus Bioefficacy. |
| AID692941 | Cytotoxicity against human HCT116 cells at 10 uM for 2 days by vi-cell cell viability analysis | 2011 | Journal of medicinal chemistry, Mar-10, Volume: 54, Issue:5 | Fluorinated N,N-dialkylaminostilbenes for Wnt pathway inhibition and colon cancer repression. |
| AID146551 | In vitro growth inhibition of NCI-H460 (human non-small cell lung carcinoma) cell line. | 2002 | Journal of medicinal chemistry, Jun-06, Volume: 45, Issue:12 | Antineoplastic agents. 465. Structural modification of resveratrol: sodium resverastatin phosphate. |
| AID1371373 | Cytotoxicity against human NCI-H460 cells assessed as decrease in cell viability after 48 hrs by MTT assay | 2017 | Journal of medicinal chemistry, 12-14, Volume: 60, Issue:23 | Polyphenolic Phytochemicals in Cancer Prevention and Therapy: Bioavailability versus Bioefficacy. |
| AID667230 | Cytotoxicity against human A2780 cells after 96 hrs by SRB assay | 2012 | European journal of medicinal chemistry, Aug, Volume: 54 | Synthesis and biological evaluation of novel (E) stilbene-based antitumor agents. |
| AID614088 | Antifungal activity against Botrytis cinerea FSU 883 at 10 mg/ml after 24 to 72 hrs by agar diffusion method | 2011 | Bioorganic & medicinal chemistry, Sep-01, Volume: 19, Issue:17 | Synthesis and antimicrobial activity of (E) stilbene derivatives. |
| AID692944 | Cytotoxicity against human LS 174T cells at 10 uM for 2 days by vi-cell cell viability analysis | 2011 | Journal of medicinal chemistry, Mar-10, Volume: 54, Issue:5 | Fluorinated N,N-dialkylaminostilbenes for Wnt pathway inhibition and colon cancer repression. |
| AID1372019 | Antioxidant activity assessed as Trolox equivalents of photolysis-induced hydroxyl radical scavenging activity using DMPO spin trap by ESR spectroscopic method | 2017 | Bioorganic & medicinal chemistry letters, 12-01, Volume: 27, Issue:23 | Resveratrol analogues like piceatannol are potent antioxidants as quantitatively demonstrated through the high scavenging ability against reactive oxygen species and methyl radical. |
| AID1614268 | Inhibition of human 5-LOX using arachidonic acid as substrate measured after 10 mins by ELISA | 2019 | Bioorganic & medicinal chemistry, 02-15, Volume: 27, Issue:4 | Design, synthesis and identification of novel coumaperine derivatives for inhibition of human 5-LOX: Antioxidant, pseudoperoxidase and docking studies. |
| AID1570237 | Inhibition of 5-LOX in human PMNL cells assessed as A23187-stimulated LTB4 production preincubated for 15 mins followed by A23187 addition and measured after 10 mins by HPLC analysis | 2019 | European journal of medicinal chemistry, Oct-15, Volume: 180 | Protective effect of piceatannol and bioactive stilbene derivatives against hypoxia-induced toxicity in H9c2 cardiomyocytes and structural elucidation as 5-LOX inhibitors. |
| AID150946 | In vitro inhibition of P388 (murine leukemia) cell proliferation. | 2002 | Journal of medicinal chemistry, Jun-06, Volume: 45, Issue:12 | Antineoplastic agents. 465. Structural modification of resveratrol: sodium resverastatin phosphate. |
| AID1238814 | Cytotoxicity against human HCT116 cells assessed as inhibition of cell growth after 24 hrs by MTT assay | 2015 | Journal of medicinal chemistry, Aug-27, Volume: 58, Issue:16 | Novel Resveratrol-Based Aspirin Prodrugs: Synthesis, Metabolism, and Anticancer Activity. |
| AID1290886 | Inhibition of Electrophorus electricus acetylcholinesterase using acetylthiocholine iodide substrate after 15 mins by spectrophotometric method | 2016 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 26, Issue:8 | Pterostilbene-O-acetamidoalkylbenzylamines derivatives as novel dual inhibitors of cholinesterase with anti-β-amyloid aggregation and antioxidant properties for the treatment of Alzheimer's disease. |
| AID1183069 | Antifungal activity against Candida lusitaniae CBS 6936 assessed as growth inhibition after 48 hrs by broth microdilution method | 2014 | Journal of natural products, Jul-25, Volume: 77, Issue:7 | Antifungal activity of resveratrol derivatives against Candida species. |
| AID1507465 | Cytotoxicity against human SH-SY5Y cells assessed as cell survival at 100 uM after 24 hrs by MTT assay relative to control | 2017 | European journal of medicinal chemistry, Aug-18, Volume: 136 | Discovery of efficient stimulators for adult hippocampal neurogenesis based on scaffolds in dragon's blood. |
| AID1083153 | Antifungal activity against Diplodia seriata assessed as mycelium denser around the initial plug and colonizing measured after 2 days by macroscopic analysis | 2012 | Journal of agricultural and food chemistry, Dec-05, Volume: 60, Issue:48 | Phenolics and their antifungal role in grapevine wood decay: focus on the Botryosphaeriaceae family. |
| AID1371393 | Cytotoxicity against human T47D cells assessed as cell viability at 34 uM after 48 hrs by MTT assay | 2017 | Journal of medicinal chemistry, 12-14, Volume: 60, Issue:23 | Polyphenolic Phytochemicals in Cancer Prevention and Therapy: Bioavailability versus Bioefficacy. |
| AID667234 | Cytotoxicity against mouse NIH/3T3 cells after 96 hrs by SRB assay | 2012 | European journal of medicinal chemistry, Aug, Volume: 54 | Synthesis and biological evaluation of novel (E) stilbene-based antitumor agents. |
| AID1452982 | Inhibition of recombinant human CYP1A1 expressed in supersomes coexpressing NADPH-CYP reductase using 7-ethoxyresorufin as substrate after 15 mins in presence of NADP+ by Lineweaver-Burk plot analysis | 2017 | European journal of medicinal chemistry, Jul-28, Volume: 135 | Inhibitors of cytochrome P450 (CYP) 1B1. |
| AID1371402 | Cytotoxicity against human U87 cells assessed as cell viability at 34 uM after 48 hrs by MTT assay | 2017 | Journal of medicinal chemistry, 12-14, Volume: 60, Issue:23 | Polyphenolic Phytochemicals in Cancer Prevention and Therapy: Bioavailability versus Bioefficacy. |
| AID1452983 | Inhibition of recombinant human CYP1B1 expressed in supersomes coexpressing NADPH-CYP reductase using 7-ethoxyresorufin as substrate after 15 mins in presence of NADP+ by Lineweaver-Burk plot analysis | 2017 | European journal of medicinal chemistry, Jul-28, Volume: 135 | Inhibitors of cytochrome P450 (CYP) 1B1. |
| AID1371372 | Cytotoxicity against human A549 cells assessed as decrease in cell viability after 48 hrs by MTT assay | 2017 | Journal of medicinal chemistry, 12-14, Volume: 60, Issue:23 | Polyphenolic Phytochemicals in Cancer Prevention and Therapy: Bioavailability versus Bioefficacy. |
| AID1354550 | Antiinflammatory activity in carrageenan induced C57BL/6 mouse model of inflammation assessed as reduction in MCP1 expression in hind paw at 30 mg/kg, ip pretreated for 1 to 2 hrs followed by carrageenan challenge measured after 6 hrs by ELISA | 2018 | Journal of natural products, 05-25, Volume: 81, Issue:5 | Natural Stilbenoids Have Anti-Inflammatory Properties in Vivo and Down-Regulate the Production of Inflammatory Mediators NO, IL6, and MCP1 Possibly in a PI3K/Akt-Dependent Manner. |
| AID1371452 | Cmax in mouse at 10 mg/kg, iv by LC-MS/MS method | 2017 | Journal of medicinal chemistry, 12-14, Volume: 60, Issue:23 | Polyphenolic Phytochemicals in Cancer Prevention and Therapy: Bioavailability versus Bioefficacy. |
| AID588497 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
| AID588497 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5 | Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
| AID588497 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1 | High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
| AID588499 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
| AID588499 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5 | Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
| AID588499 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1 | High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
| AID588501 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
| AID588501 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5 | Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
| AID588501 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1 | High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
| AID1745845 | Primary qHTS for Inhibitors of ATXN expression | |||
| AID651635 | Viability Counterscreen for Primary qHTS for Inhibitors of ATXN expression | |||
| AID1347082 | qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lassa (LASV) Arenavirus: LASV Primary Screen - GLuc reporter signal | 2020 | Antiviral research, 01, Volume: 173 | A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity. |
| AID1347083 | qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lassa (LASV) Arenavirus: Viability assay - alamar blue signal for LASV Primary Screen | 2020 | Antiviral research, 01, Volume: 173 | A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity. |
| AID504812 | Inverse Agonists of the Thyroid Stimulating Hormone Receptor: HTS campaign | 2010 | Endocrinology, Jul, Volume: 151, Issue:7 | A small molecule inverse agonist for the human thyroid-stimulating hormone receptor. |
| AID1347086 | qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lymphocytic Choriomeningitis Arenaviruses (LCMV): LCMV Primary Screen - GLuc reporter signal | 2020 | Antiviral research, 01, Volume: 173 | A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity. |
| AID504810 | Antagonists of the Thyroid Stimulating Hormone Receptor: HTS campaign | 2010 | Endocrinology, Jul, Volume: 151, Issue:7 | A small molecule inverse agonist for the human thyroid-stimulating hormone receptor. |
| AID1159607 | Screen for inhibitors of RMI FANCM (MM2) intereaction | 2016 | Journal of biomolecular screening, Jul, Volume: 21, Issue:6 | A High-Throughput Screening Strategy to Identify Protein-Protein Interaction Inhibitors That Block the Fanconi Anemia DNA Repair Pathway. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (0.37) | 18.2507 |
| 2000's | 37 (6.83) | 29.6817 |
| 2010's | 329 (60.70) | 24.3611 |
| 2020's | 174 (32.10) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be strong demand-to-supply ratio for research on this compound.
| This Compound (41.36) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 8 (1.46%) | 5.53% |
| Reviews | 37 (6.74%) | 6.00% |
| Case Studies | 1 (0.18%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 503 (91.62%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||