Page last updated: 2024-12-05

methyl tert-butyl ether

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

methyl tert-butyl ether: used to dissolve gallstones; gasoline additive [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

methyl tert-butyl ether : An ether having methyl and tert-butyl as the two alkyl components. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Cross-References

ID SourceID
PubMed CID15413
CHEMBL ID1452799
CHEBI ID27642
MeSH IDM0127360

Synonyms (157)

Synonym
tert-c4h9och3
CHEBI:27642 ,
4-01-00-01615 (beilstein handbook reference)
29i4yb3s89 ,
methyl tert-butyl ether [un2398] [flammable liquid]
ec 216-653-1
unii-29i4yb3s89
2-methoxy-2-methylpropane
methyl t-butyl ether
mtbe
methyl tertiary butyl ether
1,1-dimethylethyl methyl ether
ether, tert-butyl methyl
propane, 2-methoxy-2-methyl-
inchi=1/c5h12o/c1-5(2,3)6-4/h1-4h
NCGC00091717-01
methyl-t-butyl ether
hsdb 5847
methyl tertiary-butyl ether
2-methyl-2-methoxypropane
un2398
methyl 1,1-dimethylethyl ether
methyl-tert-butyl ether
einecs 216-653-1
brn 1730942
ccris 7596
methyl tert-butyl ether
1634-04-4
tert-butyl methyl ether
t-butyl methyl ether
tert-butyl methyl ether, anhydrous, 99.8%
B0991
AKOS000121105
NCGC00091717-02
methyl-tert-butylether
tert-butylmethyl ether
tert-butylmethylether
t-butylmethyl ether
methyltertbutyl ether
methyl-t-butylether
tertbutylmethyl ether
tox21_201184
dtxsid3020833 ,
cas-1634-04-4
dtxcid30833
NCGC00258736-01
tbme
EPITOPE ID:122671
(methyl)(tert-butyl)ether
tert-butylmethyl ether [usp-rs]
methyl tert-butyl ether [iarc]
methyl tert-butyl ether [mi]
t-butyl methyl ether [inci]
tert-butoxymethane
tert-buome
methylt-butyl ether
t-butylmethylether
methyl tert.- butyl ether
tert-butyl methylether
metyl tert-butyl ether
tert.-butyl-methyl ether
tertiary butylmethyl ether
methyl-tertbutyl ether
tert.butylmethyl ether
tertiary butyl methyl ether
methyl-tert.butylether
tertiary-butyl methyl ether
methyl tert butyl ether
tertbutyl(methyl)ether
t-butyl-methyl ether
tert-butyl-methyl-ether
tert-buyl methyl ether
methy tert-butyl ether
tert.-butylmethylether
t-butyl-methylether
methyl tert.butyl ether
(ch3)3coch3
meotbu
tert-buty methyl ether
tert. butyl methyl ether
methyl tert.-butyl ether
tert.butylmethylether
methyltertbutylether
tert butylmethyl ether
tert.-butyl methyl ether
methyltert-butyl ether
methylterbutyloxide
methyl tert-butylether
tert. butyl-methyl-ether
tert-butyl-methylether
tert.butyl methyl ether
methyl-tert.-butylether
methyl-tertiarybutyl ether
methyl tert.-butylether
tert.-butylmethyl ether
methyl-tert. butylether
methyl-tert. butyl ether
methyl tertbutyl ether
methyl-tert-butyl-ether
methyl t-butylether
tert butyl methyl ether
tert.butyl-methylether
t-buome
ter-butyl methyl ether
tert -butylmethylether
tertbutyl methyl ether
tert. butyl-methylether
methyl ter-butyl ether
tbuome
tert.-butyl-methylether
tert.-butyl methylether
tert. butylmethylether
t-butyl-methyl-ether
tert-butylmethyether
tert.-butyl-methyl-ether
tert-butyl-methyl ether
methyl-tert.butyl ether
t-butyl methyi ether
methyl-tertbutyl-ether
methyl-tert butyl ether
t-butyl methylether
tertbutylmethylether
2-methoxy-2-methyl-propane
driveron
un 2398
CHEMBL1452799
1219795-06-8
tert-butyl-d9 methyl ether
mfcd00008812
tert-butyl methyl ether, hplc grade
tert-butylmethyl ether, hplc grade
J-509782
mtbe acs grade
tert-butyl methyl ether, puriss. p.a., >=99.5% (gc)
tert-butyl methyl ether, hplc grade, for hplc, 99.8%
tert-butyl methyl ether, pra grade, >=99%
tert-butyl methyl ether, for hplc, >=99.8% (gc)
tert-butyl methyl ether, reagent grade, >=98%
tert-butyl methyl ether, analytical standard
tert-butyl methyl ether, reagent grade, 98%
tert-butyl methyl ether, for hplc, >=99.8%
tert-butyl methyl ether, acs reagent, >=99.0%
tert-butyl methyl ether, saj special grade, >=99.0%
tert-butyl methyl ether, puriss. p.a., >=99% (gc)
tert-butyl methyl ether, united states pharmacopeia (usp) reference standard
tert-butyl methyl ether, ar, >=99.5%
tert-butyl methyl ether, for hplc, >=99.9%
tert-butyl methyl ether, p.a., 99.5%
tert-butyl methyl ether, lr, >=99%
tert-butyl methyl ether, pharmaceutical secondary standard; certified reference material
methyl-tert-butylether 100 microg/ml in methanol
methyl tert-butyl ether (mtbe) 1000 microg/ml in methanol
Q412346
mtbe acs grade trace metal grade, stainless steel drum
tert-butylmethyl ether 100 microg/ml in methanol
methyl tert-butyl ether 2000 microg/ml in methanol
AMY11032

Research Excerpts

Toxicity

ExcerptReferenceRelevance
" IPA had toxic effects similar to those evoked by MTBE."( Systemic and local toxicity in the rat of methyl tert-butyl ether: a gallstone dissolution agent.
Akimoto, R; Hofmann, AF; Moossa, AR; Rieger, E; Wahlstrom, HE, 1992
)
0.55
"We evaluated the toxic effects of four currently used chemolytic solvents--dimethyl sulfoxide (DMSO, 99%), ethyl propionate (EP, 99%), tetrasodium ethyl-dimethyl tetraacetate (4Na-EDTA, 2%, pH 11), and methyl tert-butyl ether (MTBE, purity = 99."( Toxic effects of cholelitholytic solvents on gallbladder and liver. A piglet model study.
Chang, KK; Chen, CY; Chou, TC; Chow, NH; Leow, TC; Lin, XZ, 1995
)
0.48
" All of these chemicals are only moderately to mildly toxic at acute doses."( Acute toxicity of gasoline and some additives.
Kimbrough, RD; Reese, E, 1993
)
0.29
" Depending on time of exposure and endpoint measured, MTBE is toxic to various aquatic organisms at concentrations of 57-> 1000 mg/l (invertebrates), and 388-2600 mg/l (vertebrates)."( Toxicity of methyl-tert-butyl ether to freshwater organisms.
Deanovic, LA; Hinton, DE; Koger, CS; Werner, I, 2001
)
0.31
" To address concerns regarding MTBE environmental effects and to establish safe concentrations in surface waters, a collaborative effort was initiated in 1997 to develop aquatic toxicity databases sufficient to derive ambient water quality criteria for MTBE consistent with United States Environmental Protection Agency (U."( Development of a freshwater aquatic toxicity database for ambient water quality criteria for methyl tertiary-butyl ether.
Arnold, WR; Mancini, ER; Rausina, GA; Steen, AE; Wong, DC, 2001
)
0.31
" Leaded gasoline (TEL) and lead oxide are 383- and 211-fold more toxic than unleaded gasoline (MTBE) in 7 days of exposure and 627- and 290-fold more toxic in 14 days, respectively."( Comparative toxicity of tetra ethyl lead and lead oxide to earthworms, Eisenia fetida (Savigny).
Kavitha, P; Padmanabha Rao, A; Venkateswara Rao, J, 2003
)
0.32
" The toxic effects (EC(50) value) of several pure pesticides (Diuron, Linuron, Dichlofluanid, Sea nine, Irgarol and tributyltin (TBT)) were measured and compared with the EC(50) value of the pesticide mixed with MTBE, using the Vibrio fischeri and Daphnia magna acute toxicity assays."( Combined toxicity effects of MTBE and pesticides measured with Vibrio fischeri and Daphnia magna bioassays.
Chisti, Y; Ejerhoon, M; Fernández-Alba, AR; Hernando, MD, 2003
)
0.32
" MTBE was toxic to both earthworm species and the severity of response increased with increasing MTBE concentrations."( Assessing soil ecotoxicity of methyl tert-butyl ether using earthworm bioassay; closed soil microcosm test for volatile organic compounds.
An, YJ, 2005
)
0.62
" Although 3000 ppm MTBE could exert toxic effects directly on spermatogenic cells, environmental levels of MTBE did not exert toxic effects on cultured spermatogenic cells."( Evaluation of toxicity of methyl tert-butyl ether (MTBE) on mouse spermatogenic cells in vitro.
Han, XD; Li, DM, 2006
)
0.63
" MTBE is quite toxic to crop plants in contaminated soils of agricultural systems."( Phytotoxicity of methyl tert-butyl ether to common bean (Phaseolus vulgaris L.) plants.
Beltagi, MS, 2007
)
0.68
" The present data indicate that high dose MTBE may exert a direct toxic effect on Sertoli cells."( Cytotoxicity and oxidative stress study in cultured rat Sertoli cells with methyl tert-butyl ether (MTBE) exposure.
Gong, Y; Han, X; Huang, Y; Li, D; Liu, Q, 2009
)
0.58
" In fact, although available data are somehow conflicting, there is evidence that MTBE is a toxic substance that may have harmful effects on both animals and humans and an unresolved problem is the role played by MTBE metabolites, especially tertiary butyl alcohol (TBA), in determining toxic effects due to MTBE exposure."( Differential toxic effects of methyl tertiary butyl ether and tert-butanol on rat fibroblasts in vitro.
Bergamaschi, A; Bianchino, G; Boninsegna, A; Cittadini, A; De Paola, B; Iavicoli, I; Pietroiusti, A; Sgambato, A, 2009
)
0.35
" Since these additives change the combustion characteristics, this may as well influence toxic effects of the resulting emissions."( Ether oxygenate additives in gasoline reduce toxicity of exhausts.
Brüning, T; Bünger, J; Hallier, E; Krahl, J; Westphal, GA, 2010
)
0.36
" ETBE does not appear to be selectively toxic to reproduction or embryofetal development in the absence of other manifestations of general toxicity."( Ethyl t-butyl ether: review of reproductive and developmental toxicity.
de Peyster, A, 2010
)
0.36
" TBA was significantly less toxic with EC10 and EC50 for acute and chronic toxicity >1000 mg L(-1)."( Microbial toxicity of methyl tert-butyl ether (MTBE) determined with fluorescent and luminescent bioassays.
Hesselsoe, M; Lentz, T; Roslev, P, 2015
)
0.73
" Our results showed that MTBE, in particular, decreased cell viability, which was associated with significant increase at intracellular ROS level and toxic alterations in mitochondria and lysosomes in human blood lymphocytes."( Toxicity of methyl tertiary-butyl ether on human blood lymphocytes.
Pourahmad, J; Salimi, A; Seydi, E; Vaghar-Moussavi, M, 2016
)
0.43
" Although MTBE is toxic for microbial communities, the microbial consortium used here was able to resist MTBE loading rates up to 128."( Biodegradation of Methyl Tertiary Butyl Ether (MTBE) by a Microbial Consortium in a Continuous Up-Flow Packed-Bed Biofilm Reactor: Kinetic Study, Metabolite Identification and Toxicity Bioassays.
Alfonso-Gordillo, G; Cristiani-Urbina, E; Flores-Ortiz, CM; Morales-Barrera, L, 2016
)
0.43
" The adverse effects of MTBE are largely attributed to its low boiling point, resulting in a tendency to evaporate."( Superior gallstone dissolubility and safety of tert-amyl ethyl ether over methyl-tertiary butyl ether.
Ahn, J; Cho, SJ; Choi, HJ; Hong, HE; Hong, TH; Hwang, KS; Jung, JK; Jung, KY; Kim, KH; Kim, OH; Kim, SJ; Lee, SC; Lee, TY; Park, JH; Seo, H; Song, JS; You, DD, 2019
)
0.51

Pharmacokinetics

ExcerptReferenceRelevance
" The objective of this study was to develop a physiologically based pharmacokinetic (PBPK) model for MTBE and TBA in rats that will form the basis for a human model."( Development of physiologically based pharmacokinetic model for methyl tertiary-butyl ether and tertiary-butanol in male Fisher-344 rats.
Borghoff, SJ; Medinsky, MA; Murphy, JE, 1996
)
0.29
" Plasma concentrations of MTBE and t-butyl alcohol (TBA) were quantified and mean values used for pharmacokinetic analysis."( Pharmacokinetics and disposition of methyl t-butyl ether in Fischer-344 rats.
Andrews, LS; Douglas, JF; Ferdinandi, ES; Klan, M; Kneiss, JJ; Miller, MJ, 1997
)
0.3
" The current research evaluates acute CNS effects during bathing/showering by application of physiologically-based pharmacokinetic (PBPK) techniques to compare internal doses in animal toxicity studies to human exposure scenarios."( A physiologically-based pharmacokinetic model assessment of methyl t-butyl ether in groundwater for a bathing and showering determination.
Ginsberg, GL; Rao, HV, 1997
)
0.3
" The objectives of this study were to verify the ability of a physiologically based pharmacokinetic (PBPK) model to predict MTBE blood levels in humans and to investigate the effect of variability in the metabolism of MTBE and its influence on the predicted MTBE blood levels."( A physiologically based pharmacokinetic model for methyl tert-butyl ether in humans: implementing sensitivity and variability analyses.
Borghoff, SJ; Dekant, W; Licata, AC; Smith, CE, 2001
)
0.56
" These data provide the risk assessment process of pharmacokinetic information relevant to the media through which most exposures occur-air and drinking water."( Dermal, oral, and inhalation pharmacokinetics of methyl tertiary butyl ether (MTBE) in human volunteers.
Ashley, D; Blount, B; Cardinali, F; Case, M; Leavens, T; Pleil, J; Prah, J, 2004
)
0.32
" We find that individual biomarker measurements are a valuable tool in reconstruction of previous exposures and that a simple pharmacokinetic model can identify the time frames over which an exogenous chemical and the related chemical biomarker are useful."( Exposure reconstruction for reducing uncertainty in risk assessment: example using MTBE biomarkers and a simple pharmacokinetic model.
Kim, D; Pleil, JD; Prah, JD; Rappaport, SM,
)
0.13
" The method was successfully applied to a clinical pharmacokinetic study of lacidipine in healthy volunteers following oral administration."( Ultra-performance liquid chromatography-tandem mass spectrometry for the determination of lacidipine in human plasma and its application in a pharmacokinetic study.
Cheng, G; Peng, W; Tang, J; Zhao, R; Zhu, R, 2008
)
0.35
"Current physiologically based pharmacokinetic (PBPK) models for the fuel additive methyl tertiary butyl ether (MTBE) and its metabolite tertiary butyl alcohol (TBA) have not included a mechanism for chemical binding to the male rat-specific protein alpha2u-globulin, which has been postulated to be responsible for renal effects in male rats observed in toxicity and carcinogenicity studies with MTBE."( Physiologically based pharmacokinetic model of methyl tertiary butyl ether and tertiary butyl alcohol dosimetry in male rats based on binding to alpha2u-globulin.
Borghoff, SJ; Leavens, TL, 2009
)
0.35
" Recently an updated rat physiologically based pharmacokinetic (PBPK) model was published that relied on a description of MTBE and its metabolite tertiary-butyl alcohol (TBA) binding to alpha 2u-globulin, a male rat-specific protein."( Physiologically based pharmacokinetic rat model for methyl tertiary-butyl ether; comparison of selected dose metrics following various MTBE exposure scenarios used for toxicity and carcinogenicity evaluation.
Borghoff, SJ; Leavens, TL; Parkinson, H, 2010
)
0.36
" The proposed method was successfully applied to pharmacokinetic studies in humans."( A highly sensitive method for the quantification of fludrocortisone in human plasma using ultra-high-performance liquid chromatography tandem mass spectrometry and its pharmacokinetic application.
Banda, J; Gudla, SP; Lakshmanan, R; Prudhivi, R; Vvs, SP, 2015
)
0.42
" This method was successfully applied to a pharmacokinetic study of IKH12 in rat."( Development and validation of a LC-MS assay for the quantification of ikh12 a novel anti-tumor candidate in rat plasma and tissues and its application in a pharmacokinetic study.
Alcalá, M; Aldaba, E; Cossío, FP; Masdeu, C; Otaegui, D; Rodriguez-Gascón, A; San Sebastian, E; Vara, Y; Villafruela, S; Zubia, A, 2015
)
0.42
" The developed method was successfully applied to the pharmacokinetic study of the seven taxoids in rat plasma after oral administration of the crude extract of the twigs and leaves of Taxus yunnanensis."( Simultaneous determination of seven taxoids in rat plasma by UPLC-MS/MS and pharmacokinetic study after oral administration of Taxus yunnanensis extracts.
Bai, X; Gou, X; Hou, X; Huang, M; Jin, J; Li, D; Liu, B; Zhong, G, 2015
)
0.42

Bioavailability

ExcerptReferenceRelevance
" This is primarily due to the adsorption of toluene to soil particles, leading to less bioavailability of toluene to the earthworm in soil."( Comparative and combined toxicities of toluene and methyl tert-butyl ether to an Asian earthworm Perionyx excavatus.
An, YJ; Lee, WM, 2008
)
0.6
" The validated method was successfully employed for bioavailability study after oral administration of 10 mg of alfuzosin hydrochloride and 5mg of solifenacin succinate tablet formulations in eight healthy volunteers under fed condition."( Highly sensitive and rapid LC-ESI-MS/MS method for the simultaneous quantification of uroselective alpha1-blocker, alfuzosin and an antimuscarinic agent, solifenacin in human plasma.
Jangid, AG; Mistri, HN; Pudage, A; Rathod, DM; Shrivastav, PS, 2008
)
0.35

Dosage Studied

ExcerptRelevanceReference
" The uncertainties in this conclusion are based on the lack of information on dose-response relationship at reasonable, projected exposure levels and of studies examining end points of concern in sensitive species."( Health effects of oxygenated fuels.
Costantini, MG, 1993
)
0.29
"To estimate potential public health benefits from ozone (O3) pollution reduction attributable to the use of methyl tertiary-butyl ether (MTBE) in gasoline, O3 dose-response estimates from the biomedical literature were combined with model estimates of O3 reduction."( Projection of health benefits from ambient ozone reduction related to the use of methyl tertiary butyl ether (MTBE) in the reformulated gasoline program.
Erdal, S; Gong, H; Linn, WS; Rykowski, R, 1997
)
0.3
" To study tert-butyl alcohol metabolism, rats were dosed either with tert-butyl alcohol at natural carbon isotope ratio or with 13C-enriched tert-butyl alcohol (250 mg/kg of body weight), urine was collected, and metabolites were identified by NMR and GC/MS."( Biotransformation of 12C- and 2-13C-labeled methyl tert-butyl ether, ethyl tert-butyl ether, and tert-butyl alcohol in rats: identification of metabolites in urine by 13C nuclear magnetic resonance and gas chromatography/mass spectrometry.
Amberg, A; Bernauer, U; Dekant, W; Scheutzow, D, 1998
)
0.56
" In rat primary hepatocyte UDS assay, a dose-response relationship was observed, which meant that MTBE might damage normal DNA and induce unscheduled DNA synthesis."( Mutagenicity of methyl tertiary butyl ether.
Huang, G; Ye, S; Yuan, D; Zhang, H; Zhou, W, 2000
)
0.31
" Thus, the present study, although showing increased total symptoms among SRSs when exposed to gasoline with 15% MTBE, did not support a dose-response relationship for MTBE exposure nor the symptom specificity associated with MTBE in epidemiologic studies."( Controlled human exposure to methyl tertiary butyl ether in gasoline: symptoms, psychophysiologic and neurobehavioral responses of self-reported sensitive persons.
Edelberg, R; Fiedler, N; Hamer, R; Kelly-McNeil, K; Lee, C; Lehrer, P; Lioy, PJ; Mohr, S; Opiekun, RE; Wainman, T; Weisel, C, 2000
)
0.31
" Studies of olfaction did not support unusual sensitivity, defined as lower odor thresholds, among MCS subjects; however, a dose-response pattern of symptoms was observed in response to suprathreshold concentrations of phenyl ethyl alcohol."( Controlled exposures to volatile organic compounds in sensitive groups.
Fiedler, N; Kipen, HM, 2001
)
0.31
" It was found that MTBE definitely formed adducts with DNA in mouse lung, liver, and kidney in a log/log linear dose-response relationship."( Formation of MTBE-DNA adducts in mice measured with accelerator mass spectrometry.
Du, HF; Liu, KX; Liu, YF; Peng, SX; Tang, XY; Wang, HF; Xu, LH, 2005
)
0.33
" Cmax values for MTBE are achieved almost immediately after oral dosing and within 2 h of continuous inhalation."( Methyl tertiary-butyl ether: studies for potential human health hazards.
McGregor, D, 2006
)
0.33
" While MTBE photodegradation rates increased with increasing dosage of H2O2 (5-15 mM) and TiO2 (0."( Photodegradation of methyl tert-butyl ether (MTBE) by UV/H2O2 and UV/TiO2.
Chen, Y; Hu, Q; Mao, K; Wang, Z; Xiong, Y; Zhang, C; Zhang, X; Zhu, M, 2008
)
0.67
" The treatment was conducted in a semi-batch reactor under different experimental conditions by varying ozone gas dosage and incident UV light intensity."( Treatment of groundwater contaminated with gasoline components by an ozone/UV process.
Garoma, T; Gurol, MD; Osibodu, O; Thotakura, L, 2008
)
0.35
" Using a similar dosing protocol, others had initially reported disruption of seminiferous tubules in MTBE-gavaged mice, although later conclusions published were consistent with our findings."( Effect of oral methyl-t-butyl ether (MTBE) on the male mouse reproductive tract and oxidative stress in liver.
de Peyster, A; Goldberg, B; Gonzales, F; Klaunig, JE; Pu, X; Rodriguez, Y; Shuto, R,
)
0.13
" Early postnatal rat pup deaths show no clear dose-response and have largely been attributed to total litter losses with accompanying evidence of maternal neglect or frank maternal morbidity."( Ethyl t-butyl ether: review of reproductive and developmental toxicity.
de Peyster, A, 2010
)
0.36
" The results indicated that the DCAce production increased with the increase of chloramine dosage when the chloramine addition was in the range of 5-30 mg · L(-1)."( [Formation Mechanism of the Disinfection By-product 1, 1-Dichloroacetone in Drinking Water].
Ding, CS; Meng, Z; Miao, J; Xu, YY, 2015
)
0.42
" Dose-Response model was found to best describe the breakthrough curves."( Adsorption of methyl tert-butyl ether (MTBE) onto ZSM-5 zeolite: Fixed-bed column tests, breakthrough curve modelling and regeneration.
Al-Tabbaa, A; Jin, F; Lynch, R; Shen, Z; Wang, F; Zhang, Y, 2019
)
0.87
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Roles (3)

RoleDescription
non-polar solventnull
fuel additiveAny additive that enhances the efficiency of fuel.
metaboliteAny intermediate or product resulting from metabolism. The term 'metabolite' subsumes the classes commonly known as primary and secondary metabolites.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Drug Classes (1)

ClassDescription
etherAn organooxygen compound with formula ROR, where R is not hydrogen.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Pathways (1)

PathwayProteinsCompounds
methyl tert-butyl ether degradation1425

Protein Targets (5)

Potency Measurements

ProteinTaxonomyMeasurementAverage (µ)Min (ref.)Avg (ref.)Max (ref.)Bioassay(s)
RAR-related orphan receptor gammaMus musculus (house mouse)Potency0.03340.006038.004119,952.5996AID1159521
aldehyde dehydrogenase 1 family, member A1Homo sapiens (human)Potency17.78280.011212.4002100.0000AID1030
progesterone receptorHomo sapiens (human)Potency13.29670.000417.946075.1148AID1346784
retinoic acid nuclear receptor alpha variant 1Homo sapiens (human)Potency8.38960.003041.611522,387.1992AID1159555
farnesoid X nuclear receptorHomo sapiens (human)Potency59.92920.375827.485161.6524AID743217
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (977)

TimeframeStudies, This Drug (%)All Drugs %
pre-199089 (9.11)18.7374
1990's241 (24.67)18.2507
2000's405 (41.45)29.6817
2010's213 (21.80)24.3611
2020's29 (2.97)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 84.64

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be very strong demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index84.64 (24.57)
Research Supply Index6.98 (2.92)
Research Growth Index4.79 (4.65)
Search Engine Demand Index151.86 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (84.64)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials14 (1.32%)5.53%
Reviews128 (12.08%)6.00%
Case Studies30 (2.83%)4.05%
Observational0 (0.00%)0.25%
Other888 (83.77%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]