molsidomine has been researched along with Necrosis in 8 studies
Molsidomine: A morpholinyl sydnone imine ethyl ester, having a nitrogen in place of the keto oxygen. It acts as NITRIC OXIDE DONORS and is a vasodilator that has been used in ANGINA PECTORIS.
molsidomine : A member of the class of oxadiazoles that is 1,2,3-oxadiazole substituted by morpholin-4-yl and (ethoxycarbonyl)azanidyl groups at positions 3 and 5, respectively. It is used as a vasodilator drug for the treatment of myocardial ischemic syndrome and congestive heart failure.
Necrosis: The death of cells in an organ or tissue due to disease, injury or failure of the blood supply.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We observed that N-nitro-L-arginine (NOLA), a nitric oxide biosynthesis inhibitor, exacerbated necrosis in the rabbit heart during ischemia-reperfusion while 3-morpholino-sydnonimine-hydrochloride (SIN-1) (a nitric oxide donor) reduced myocardial damage in the same model." | 3.69 | The opposing effects of an inhibitor of nitric oxide synthesis and of a donor of nitric oxide in rabbits undergoing myocardial ischemia reperfusion. ( Fung, KP; Wu, J; Wu, TW; Zeng, LH, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (12.50) | 18.7374 |
| 1990's | 4 (50.00) | 18.2507 |
| 2000's | 1 (12.50) | 29.6817 |
| 2010's | 2 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| He, Y | 1 |
| Zhang, Y | 1 |
| Zhang, D | 1 |
| Zhang, M | 1 |
| Wang, M | 1 |
| Jiang, Z | 1 |
| Otero, M | 1 |
| Chen, J | 1 |
| Agbani, E | 1 |
| Coats, P | 1 |
| Wadsworth, RM | 1 |
| Bonfoco, E | 1 |
| Krainc, D | 1 |
| Ankarcrona, M | 1 |
| Nicotera, P | 1 |
| Lipton, SA | 1 |
| Fung, KP | 1 |
| Wu, TW | 2 |
| Zeng, LH | 2 |
| Wu, J | 2 |
| Law, A | 1 |
| Gow, AJ | 1 |
| Chen, Q | 1 |
| Gole, M | 1 |
| Themistocleous, M | 1 |
| Lee, VM | 1 |
| Ischiropoulos, H | 1 |
| Vértesi, C | 1 |
| Knopf, E | 1 |
| Körmöczy, PS | 1 |
| Khal'fen, ESh | 1 |
| Shvarts, IL | 1 |
| Zolotarev, VA | 1 |
8 other studies available for molsidomine and Necrosis
| Article | Year |
|---|---|
3-morpholinosydnonimine (SIN-1)-induced oxidative stress leads to necrosis in hypertrophic chondrocytes in vitro.
Topics: Animals; Apoptosis; Cartilage; Case-Control Studies; Cell Line; Cell Survival; Chondrocytes; Dose-Re | 2018 |
Threshold of peroxynitrite cytotoxicity in bovine pulmonary artery endothelial and smooth muscle cells.
Topics: Animals; Apoptosis; Caspase 3; Cattle; Endothelial Cells; Endothelium, Vascular; L-Lactate Dehydroge | 2011 |
Apoptosis and necrosis: two distinct events induced, respectively, by mild and intense insults with N-methyl-D-aspartate or nitric oxide/superoxide in cortical cell cultures.
Topics: Animals; Apoptosis; Cells, Cultured; Cerebral Cortex; Cysteine; DNA; Free Radicals; Kinetics; Molsid | 1995 |
The opposing effects of an inhibitor of nitric oxide synthesis and of a donor of nitric oxide in rabbits undergoing myocardial ischemia reperfusion.
Topics: Analysis of Variance; Animals; Arginine; Blood Pressure; Heart; Molsidomine; Myocardial Ischemia; My | 1994 |
Aortic endothelial cells damaged by a nitric oxide donor and protected by flavonoids.
Topics: Animals; Aorta; Cells, Cultured; Dose-Response Relationship, Drug; Endothelium, Vascular; Flavonoids | 1999 |
Two distinct mechanisms of nitric oxide-mediated neuronal cell death show thiol dependency.
Topics: Acetylcysteine; Animals; Cell Death; Cell Differentiation; Cell Line; Cell Survival; Cyclic GMP; Hyd | 2000 |
Effect of nitroglycerin and a nitroglycerin-like substance in isoprenaline (ISO) necrosis and hypoxia.
Topics: Animals; Hypoxia; Isoproterenol; Molsidomine; Necrosis; Nitroglycerin; Rats | 1990 |
[Effect of corvaton on ischemic left-ventricular damage and hemodynamic indicators in patients with acute myocardial infarction].
Topics: Adult; Aged; Coronary Circulation; Female; Heart Ventricles; Hemodynamics; Humans; Male; Middle Aged | 1988 |