Mitogen-activated protein kinase kinase kinase 8

A mitogen-activated protein kinase kinase kinase 8 that is encoded in the genome of human. [PRO:DNx]

EC 2.7.11.25;
Cancer Osaka thyroid oncogene;
Proto-oncogene c-Cot;
Serine/threonine-protein kinase cot;
Tumor progression locus 2;
TPL-2

Research

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
ro 31-8220	Homo sapiens (human)	IC50	9.9500	1	1
gefitinib	Homo sapiens (human)	IC50	1.0000	1	1
ellagic acid	Homo sapiens (human)	IC50	2.3700	1	1
a 770041	Homo sapiens (human)	IC50	25.0000	1	1
pd 0325901	Homo sapiens (human)	IC50	25.0000	1	1
nvp-aew541	Homo sapiens (human)	IC50	10.0000	1	1
pf 00299804	Homo sapiens (human)	IC50	3.5700	1	1
4-[2-(2-chloro-4-fluoroanilino)-5-methyl-4-pyrimidinyl]-N-[(1S)-1-(3-chlorophenyl)-2-hydroxyethyl]-1H-pyrrole-2-carboxamide	Homo sapiens (human)	Ki	4.0000	1	1
2-({2-[(3-hydroxyphenyl)amino]pyrimidin-4-yl}amino)benzamide	Homo sapiens (human)	IC50	50.0000	1	1
8-chloro-4-(3-chloro-4-fluoroanilino)-6-[[1-(1-ethyl-4-piperidinyl)-4-triazolyl]methylamino]-3-quinolinecarbonitrile	Homo sapiens (human)	IC50	0.0016	2	2

This protein enables 6 target(s):

Target	Category	Definition
magnesium ion binding	molecular function	Binding to a magnesium (Mg) ion. [GOC:ai]
protein serine/threonine kinase activity	molecular function	Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. [GOC:bf, MetaCyc:PROTEIN-KINASE-RXN, PMID:2956925]
MAP kinase kinase kinase activity	molecular function	Catalysis of the phosphorylation and activation of a MAP kinase kinase; each MAP kinase kinase can be phosphorylated by any of several MAP kinase kinase kinases. [PMID:9561267]
protein binding	molecular function	Binding to a protein. [GOC:go_curators]
ATP binding	molecular function	Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. [ISBN:0198506732]
protein serine kinase activity	molecular function	Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate. [RHEA:17989]

This protein is located in 1 target(s):

Target	Category	Definition
cytosol	cellular component	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]

This protein is involved in 3 target(s):

Target	Category	Definition
MAPK cascade	biological process	An intracellular protein kinase cascade containing at least a MAP kinase (MAPK). It starts with the activation of a MAP3K, and the consecutive activation of a MPK2K and a MAPK. The cascade can also contain an additional tier: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinase in the downstream tier to transmit a signal within a cell. [PMID:20811974, PMID:9561267]
protein phosphorylation	biological process	The process of introducing a phosphate group on to a protein. [GOC:hb]
T cell costimulation	biological process	The process of providing, via surface-bound receptor-ligand pairs, a second, antigen-independent, signal in addition to that provided by the T cell receptor to augment T cell activation. [ISBN:0781735149]