Receptor-type tyrosine-protein phosphatase epsilon

A receptor-type tyrosine-protein phosphatase epsilon that is encoded in the genome of human. [PRO:DNx, UniProtKB:P23469]

Protein-tyrosine phosphatase epsilon;
R-PTP-epsilon;
EC 3.1.3.48

Research

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
5-iodo-2-(oxaloamino)benzoic acid	Homo sapiens (human)	Ki	33.0000	1	1
oleanolic acid	Homo sapiens (human)	IC50	40.0000	1	1
ursolic acid	Homo sapiens (human)	IC50	40.0000	1	1
celastrol	Homo sapiens (human)	IC50	500.0000	1	1
2-(oxaloamino)benzoic acid	Homo sapiens (human)	Ki	130.0000	1	1
cefsulodin	Homo sapiens (human)	IC50	200.0000	1	1
illudalic acid	Homo sapiens (human)	IC50	100.0000	1	1
corosolic acid	Homo sapiens (human)	IC50	40.0000	1	1

This protein enables 3 target(s):

Target	Category	Definition
transmembrane receptor protein tyrosine phosphatase activity	molecular function	Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate. [EC:3.1.3.48]
protein binding	molecular function	Binding to a protein. [GOC:go_curators]
protein tyrosine phosphatase activity	molecular function	Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate. [EC:3.1.3.48]

This protein is located in 3 target(s):

Target	Category	Definition
nucleus	cellular component	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators]
cytoplasm	cellular component	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684]
plasma membrane	cellular component	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]

This protein is involved in 2 target(s):

Target	Category	Definition
protein dephosphorylation	biological process	The process of removing one or more phosphoric residues from a protein. [GOC:hb]
negative regulation of insulin receptor signaling pathway	biological process	Any process that stops, prevents, or reduces the frequency, rate or extent of insulin receptor signaling. [GOC:bf]