Transmembrane prolyl 4-hydroxylase

A transmembrane prolyl 4-hydroxylase that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NXG6]

P4H-TM;
EC 1.14.11.29;
Hypoxia-inducible factor prolyl hydroxylase 4;
HIF-PH4;
HIF-prolyl hydroxylase 4;
HPH-4

Research

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
picolinic acid	Homo sapiens (human)	IC50	105.7500	2	2
2,2'-dipyridyl	Homo sapiens (human)	IC50	34.2000	1	1
fusaric acid	Homo sapiens (human)	IC50	149.0000	1	1
2,5-pyridinedicarboxylic acid	Homo sapiens (human)	IC50	5.3933	3	3

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
glycyrrhetinic acid	Homo sapiens (human)	EC50	50.0000	1	1
oleanolic acid	Homo sapiens (human)	EC50	50.0000	1	1
ursolic acid	Homo sapiens (human)	EC50	50.0000	1	1
betulinic acid	Homo sapiens (human)	EC50	50.0000	1	1
maslinic acid	Homo sapiens (human)	EC50	50.0000	1	1

This protein enables 6 target(s):

Target	Category	Definition
iron ion binding	molecular function	Binding to an iron (Fe) ion. [GOC:ai]
calcium ion binding	molecular function	Binding to a calcium ion (Ca2+). [GOC:ai]
2-oxoglutarate-dependent dioxygenase activity	molecular function	Catalysis of the reaction: A + 2-oxoglutarate + O2 = B + succinate + CO2. This is an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from 2-oxoglutarate and one other donor, and one atom of oxygen is incorporated into each donor. [GOC:mah]
L-ascorbic acid binding	molecular function	Binding to L-ascorbic acid, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate; L-ascorbic acid is vitamin C and has co-factor and anti-oxidant activities in many species. [GOC:mah]
hypoxia-inducible factor-proline dioxygenase activity	molecular function	Catalysis of the reaction: 2-oxoglutarate + L-prolyl-[hypoxia-inducible factor alpha subunit] + O2 = CO2 + succinate + trans-4-hydroxy-L-prolyl-[hypoxia-inducible factor alpha subunit]. [PMID:11595184, PMID:11598268]
procollagen-proline 4-dioxygenase activity	molecular function	Catalysis of the reaction: procollagen L-proline + 2-oxoglutarate + O2 = procollagen trans-4-hydroxy-L-proline + succinate + CO2. [EC:1.14.11.2]

This protein is located in 1 target(s):

Target	Category	Definition
endoplasmic reticulum membrane	cellular component	The lipid bilayer surrounding the endoplasmic reticulum. [GOC:mah]

This protein is active in 1 target(s):

Target	Category	Definition
endoplasmic reticulum	cellular component	The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). [ISBN:0198506732]

This protein is involved in 2 target(s):

Target	Category	Definition
regulation of erythrocyte differentiation	biological process	Any process that modulates the frequency, rate or extent of erythrocyte differentiation. [GOC:go_curators]
peptidyl-proline hydroxylation to 4-hydroxy-L-proline	biological process	The modification of peptidyl-proline to form 4-hydroxy-L-proline; catalyzed by procollagen-proline,2-oxoglutarate-4-dioxygenase. [RESID:AA0030]