Page last updated: 2024-08-07 16:13:06
Catechol O-methyltransferase
A catechol O-methyltransferase that is encoded in the genome of rat. [OMA:P22734, PRO:DNx]
Synonyms
EC 2.1.1.6
Research
Bioassay Publications (13)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 5 (38.46) | 18.7374 |
| 1990's | 1 (7.69) | 18.2507 |
| 2000's | 2 (15.38) | 29.6817 |
| 2010's | 4 (30.77) | 24.3611 |
| 2020's | 1 (7.69) | 2.80 |
Compounds (27)
Drugs with Inhibition Measurements
Drugs with Activation Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| rosiglitazone | Rattus norvegicus (Norway rat) | EC50 | 0.2200 | 1 | 3 |
Drugs with Other Measurements
Emerging targets and new small molecule therapies in Parkinson's disease treatment.Bioorganic & medicinal chemistry, , Apr-01, Volume: 24, Issue:7, 2016
Synthesis and biological evaluation of a novel series of "ortho-nitrated" inhibitors of catechol-O-methyltransferase.Journal of medicinal chemistry, , Dec-15, Volume: 48, Issue:25, 2005
Evaluation of nitrocatechol chalcone and pyrazoline derivatives as inhibitors of catechol-O-methyltransferase and monoamine oxidase.Bioorganic & medicinal chemistry letters, , 06-15, Volume: 30, Issue:12, 2020
Synthesis and biological evaluation of a novel series of "ortho-nitrated" inhibitors of catechol-O-methyltransferase.Journal of medicinal chemistry, , Dec-15, Volume: 48, Issue:25, 2005