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thalidomide and Necrosis

thalidomide has been researched along with Necrosis in 21 studies

Thalidomide: A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, but withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of immunological and inflammatory disorders. Thalidomide displays immunosuppressive and anti-angiogenic activity. It inhibits release of TUMOR NECROSIS FACTOR-ALPHA from monocytes, and modulates other cytokine action.
thalidomide : A racemate comprising equimolar amounts of R- and S-thalidomide.
2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione : A dicarboximide that is isoindole-1,3(2H)-dione in which the hydrogen attached to the nitrogen is substituted by a 2,6-dioxopiperidin-3-yl group.

Necrosis: The death of cells in an organ or tissue due to disease, injury or failure of the blood supply.

Research Excerpts

ExcerptRelevanceReference
" Osteonecrosis of the jaw (ONJ) is an emerging serious side effect of the new generation bisphosphonates with a growing number of reports related to this pathological entity."7.75Osteonecrosis of the jaw in patients with multiple myeloma treated with zoledronic acid. ( Aki, SZ; Cetiner, M; Cetiner, S; Gultekin, SE; Haznedar, R; Kahraman, SA; Kocakahyaoglu, B; Sucak, GT, 2009)
" Osteonecrosis of the jaw (ONJ) is an emerging serious side effect of the new generation bisphosphonates with a growing number of reports related to this pathological entity."3.75Osteonecrosis of the jaw in patients with multiple myeloma treated with zoledronic acid. ( Aki, SZ; Cetiner, M; Cetiner, S; Gultekin, SE; Haznedar, R; Kahraman, SA; Kocakahyaoglu, B; Sucak, GT, 2009)
" Lucio's phenomenon is a syndrome distinct from erythema nodosum leprosum as indicated by an absence of fever, leukocytosis and tenderness, a failure to respond to thalidomide, and a restriction to patients with diffuse nonnodular lepromatous leprosy."3.66Lucio's phenomenon and diffuse nonnodular lepromatous leprosy. ( Levan, NE; Rea, TH, 1978)
" Animal models of hemifacial microsomia and thalidomide-induced otomandibular dysostosis are described; the causal mechanism of malformation appeared to be closely related to the formation of a hematoma at the time of development of the stapedial arterial systems."3.65Hemorrhage in development of the face. ( Poswillo, D, 1975)
" The present review examines the drug's pharmacokinetics, discusses the main adverse renal effects that are associated with lenalidomide treatment, and makes recommendations for dosage adjustment in patients with underlying renal impairment."2.53[Lenalidomide nephrotoxicity]. ( Izzedine, H; Kheder El-Fekih, R, 2016)
" This dosage form permits the prolonged drug release."1.39Evaluation of the effects of thalidomide-loaded biodegradable devices in solid Ehrlich tumor. ( Dantas Cassali, G; Ligorio Fialho, S; Maria de Souza, C; Pereira, BG; Silva-Cunha, A, 2013)
" Rats with implanted liver tumors were randomized into four treatment groups: 1) Zd6126 (Zd); 2) Thalidomide (Tha); 3) Zd in combination with Tha (ZdTha); and 4) controls."1.38Enhanced antitumor efficacy of a vascular disrupting agent combined with an antiangiogenic in a rat liver tumor model evaluated by multiparametric MRI. ( Chen, F; Cona, MM; De Geest, B; De Keyzer, F; Feng, Y; Jiang, Y; Li, J; Marchal, G; Ni, Y; Oyen, R; Verfaillie, C; Wang, H; Yu, J; Zheng, K, 2012)
"Thalidomide-treated group was given thalidomide (10mg/kg/day) intraperitoneally for 10 consecutive days."1.32Thalidomide salvages lethal hepatic necroinflammation and accelerates recovery from cirrhosis in rats. ( Chen, MF; Ho, YP; Huang, SF; Jan, YY; Yeh, JN; Yeh, TS, 2004)
"Thalidomide has no effect on tumor growth, but is also associated with increased VEGF and p53 expression."1.31Vascular endothelial growth factor monoclonal antibody inhibits growth of anaplastic thyroid cancer xenografts in nude mice. ( Bauer, AJ; Doniparthi, NK; Francis, GL; Patel, A; Ringel, MD; Saji, M; Terrell, R; Tuttle, RM, 2002)
"Thalidomide treatment resulted in a significant reduction in tumor necrosis factor-alpha, interleukin 6 (IL-6) and IL-10 protein levels (blood) and mRNA expression (lungs)."1.30Effect of cytokine modulation by thalidomide on the granulomatous response in murine tuberculosis. ( Freedman, VH; Freeman, S; Kaplan, G; Laochumroonvorapong, P; Moreira, AL; Tsenova-Berkova, L; Wang, J, 1997)

Research

Studies (21)

TimeframeStudies, this research(%)All Research%
pre-19906 (28.57)18.7374
1990's1 (4.76)18.2507
2000's6 (28.57)29.6817
2010's8 (38.10)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Khammar, Z1
Ouazzani, M1
Bennani, B1
Oubelkacem, N1
Berrady, R1
Chen, F2
De Keyzer, F2
Feng, YB1
Cona, MM2
Yu, J2
Marchal, G2
Oyen, R2
Ni, YC1
Kheder El-Fekih, R1
Izzedine, H1
Li, KD1
Salama, ME1
Fernández-Martínez, E1
Pérez-Hernández, N1
Muriel, P1
Pérez-Alvarez, V1
Shibayama, M1
Tsutsumi, V1
Cetiner, S1
Sucak, GT1
Kahraman, SA1
Aki, SZ1
Kocakahyaoglu, B1
Gultekin, SE1
Cetiner, M1
Haznedar, R1
Skamene, S1
Rotondo, RL1
Shustik, C1
Roberge, D1
Feng, Y2
Zheng, K1
Li, J1
Wang, H1
Jiang, Y1
Verfaillie, C1
De Geest, B1
Ni, Y1
Rigual, D1
Qiu, J1
Fenstermaker, RA1
Fabiano, AJ1
Pereira, BG1
Ligorio Fialho, S1
Maria de Souza, C1
Dantas Cassali, G1
Silva-Cunha, A1
Bauer, AJ1
Terrell, R1
Doniparthi, NK1
Patel, A1
Tuttle, RM1
Saji, M1
Ringel, MD1
Francis, GL1
Staak, JO1
Glossmann, JP1
Esser, JM1
Diehl, V1
Mietz, H1
Josting, A1
RICKENBACHER, J1
Friedman, L1
Shue, GM1
Hove, EL1
Yeh, TS1
Ho, YP1
Huang, SF1
Yeh, JN1
Jan, YY1
Chen, MF1
Zhao, D1
Jiang, L1
Hahn, EW1
Mason, RP1
Torras, H1
Lecha, M1
Mascaró/, JM1
Moreira, AL1
Tsenova-Berkova, L1
Wang, J1
Laochumroonvorapong, P1
Freeman, S1
Freedman, VH1
Kaplan, G1
Rea, TH1
Levan, NE1
Poswillo, D1
Marin-Padilla, M1
Benirschke, K1

Reviews

2 reviews available for thalidomide and Necrosis

ArticleYear
[Lenalidomide nephrotoxicity].
    Bulletin du cancer, 2016, Volume: 103, Issue:5

    Topics: Graft vs Host Disease; Humans; Immunologic Factors; Kidney; Kidney Tubules; Lenalidomide; Necrosis;

2016
Therapy Effect: Impact on Bone Marrow Morphology.
    Surgical pathology clinics, 2016, Volume: 9, Issue:1

    Topics: Antineoplastic Agents; Atrophy; Bone Marrow; Cytokines; Hematologic Neoplasms; Humans; Imatinib Mesy

2016

Other Studies

19 other studies available for thalidomide and Necrosis

ArticleYear
[Digital ischemia revealing multiple myeloma].
    Journal de medecine vasculaire, 2018, Volume: 43, Issue:1

    Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Bortezomib; Cryoglobulinemia; Dexamethasone; F

2018
Separate calculation of DW-MRI in assessing therapeutic effect in liver tumors in rats.
    World journal of gastroenterology, 2013, Dec-21, Volume: 19, Issue:47

    Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Combined Chemotherapy Protocols; Diffusion Magnetic

2013
The thalidomide analog 3-phthalimido-3-(3,4-dimethoxyphenyl)-propanoic acid improves the biliary cirrhosis in the rat.
    Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie, 2009, Volume: 61, Issue:5

    Topics: Animals; Fibrosis; Liver Cirrhosis, Biliary; Liver Function Tests; Male; Necrosis; Rats; Rats, Wista

2009
Osteonecrosis of the jaw in patients with multiple myeloma treated with zoledronic acid.
    Journal of bone and mineral metabolism, 2009, Volume: 27, Issue:4

    Topics: Adult; Aged; Bone Density Conservation Agents; Bone Resorption; Dexamethasone; Diphosphonates; Femal

2009
Necrosis following skull base irradiation and stem cell transplant for multiple myeloma.
    American journal of hematology, 2010, Volume: 85, Issue:9

    Topics: Antineoplastic Combined Chemotherapy Protocols; Cranial Irradiation; Dexamethasone; Diphosphonates;

2010
Enhanced antitumor efficacy of a vascular disrupting agent combined with an antiangiogenic in a rat liver tumor model evaluated by multiparametric MRI.
    PloS one, 2012, Volume: 7, Issue:7

    Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protoc

2012
Tumoral Bing-Neel Syndrome presenting as a cerebellar mass.
    Clinical neurology and neurosurgery, 2013, Volume: 115, Issue:6

    Topics: Anti-Inflammatory Agents; Antibodies, Monoclonal, Murine-Derived; Antineoplastic Agents; Antineoplas

2013
Evaluation of the effects of thalidomide-loaded biodegradable devices in solid Ehrlich tumor.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2013, Volume: 67, Issue:2

    Topics: Absorbable Implants; Angiogenesis Inducing Agents; Angiogenesis Inhibitors; Animals; Antineoplastic

2013
Vascular endothelial growth factor monoclonal antibody inhibits growth of anaplastic thyroid cancer xenografts in nude mice.
    Thyroid : official journal of the American Thyroid Association, 2002, Volume: 12, Issue:11

    Topics: Angiogenesis Inhibitors; Animals; Antibodies, Monoclonal; Body Weight; Carcinoma; Cell Division; End

2002
Thalidomide for systemic capillary leak syndrome.
    The American journal of medicine, 2003, Volume: 115, Issue:4

    Topics: Capillary Leak Syndrome; Capillary Permeability; Compartment Syndromes; Humans; Immunosuppressive Ag

2003
[EXPERIMENTS WITH CONTERGAN IN CHICK EMBRYOS. PRELIMINARY RESULTS].
    Deutsche medizinische Wochenschrift (1946), 1963, Nov-15, Volume: 88

    Topics: Abnormalities, Drug-Induced; Cardiovascular System; Chick Embryo; Ectromelia; Kidney; Liver; Myocard

1963
RESPONSE OF RATS TO THALIDOMIDE AS AFFECTED BY RIBOFLAVIN OR FOLIC ACID DEFICIENCY.
    The Journal of nutrition, 1965, Volume: 85, Issue:3

    Topics: Amino Acid Oxidoreductases; Avitaminosis; D-Amino-Acid Oxidase; Electron Transport Complex II; Flavi

1965
Thalidomide salvages lethal hepatic necroinflammation and accelerates recovery from cirrhosis in rats.
    Journal of hepatology, 2004, Volume: 41, Issue:4

    Topics: Animals; Collagenases; Hepatitis; Kupffer Cells; Liver; Liver Cirrhosis, Experimental; Male; Matrix

2004
Continuous low-dose (metronomic) chemotherapy on rat prostate tumors evaluated using MRI in vivo and comparison with histology.
    Neoplasia (New York, N.Y.), 2005, Volume: 7, Issue:7

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Area Under Curve; Cyclophosphami

2005
[Thalidomide in the treatment of aphthosis and Behçet's disease. 4 years' experience].
    Medicina cutanea ibero-latino-americana, 1982, Volume: 10, Issue:2

    Topics: Adolescent; Adult; Aged; Behcet Syndrome; Drug Evaluation; Female; Humans; Male; Middle Aged; Necros

1982
Effect of cytokine modulation by thalidomide on the granulomatous response in murine tuberculosis.
    Tubercle and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease, 1997, Volume: 78, Issue:1

    Topics: Acute Disease; Animals; Apoptosis; Cytokines; Female; Immunosuppressive Agents; Interleukin-10; Inte

1997
Lucio's phenomenon and diffuse nonnodular lepromatous leprosy.
    Archives of dermatology, 1978, Volume: 114, Issue:7

    Topics: Adult; Dapsone; Erythema Nodosum; Female; Humans; Ischemia; Leprosy; Lymphopenia; Male; Middle Aged;

1978
Hemorrhage in development of the face.
    Birth defects original article series, 1975, Volume: 11, Issue:7

    Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Animals; Arteries; Craniofacial Dysostosis; Di

1975
Thalidomide injury to the myocardium of armadillo embryos.
    Journal of embryology and experimental morphology, 1965, Volume: 13, Issue:3

    Topics: Abnormalities, Drug-Induced; Animals; Embryo, Mammalian; Female; Heart; Myocardium; Necrosis; Pregna

1965