thalidomide has been researched along with Necrosis in 21 studies
Thalidomide: A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, but withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of immunological and inflammatory disorders. Thalidomide displays immunosuppressive and anti-angiogenic activity. It inhibits release of TUMOR NECROSIS FACTOR-ALPHA from monocytes, and modulates other cytokine action.
thalidomide : A racemate comprising equimolar amounts of R- and S-thalidomide.
2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione : A dicarboximide that is isoindole-1,3(2H)-dione in which the hydrogen attached to the nitrogen is substituted by a 2,6-dioxopiperidin-3-yl group.
Necrosis: The death of cells in an organ or tissue due to disease, injury or failure of the blood supply.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Osteonecrosis of the jaw (ONJ) is an emerging serious side effect of the new generation bisphosphonates with a growing number of reports related to this pathological entity." | 7.75 | Osteonecrosis of the jaw in patients with multiple myeloma treated with zoledronic acid. ( Aki, SZ; Cetiner, M; Cetiner, S; Gultekin, SE; Haznedar, R; Kahraman, SA; Kocakahyaoglu, B; Sucak, GT, 2009) |
| " Osteonecrosis of the jaw (ONJ) is an emerging serious side effect of the new generation bisphosphonates with a growing number of reports related to this pathological entity." | 3.75 | Osteonecrosis of the jaw in patients with multiple myeloma treated with zoledronic acid. ( Aki, SZ; Cetiner, M; Cetiner, S; Gultekin, SE; Haznedar, R; Kahraman, SA; Kocakahyaoglu, B; Sucak, GT, 2009) |
| " Lucio's phenomenon is a syndrome distinct from erythema nodosum leprosum as indicated by an absence of fever, leukocytosis and tenderness, a failure to respond to thalidomide, and a restriction to patients with diffuse nonnodular lepromatous leprosy." | 3.66 | Lucio's phenomenon and diffuse nonnodular lepromatous leprosy. ( Levan, NE; Rea, TH, 1978) |
| " Animal models of hemifacial microsomia and thalidomide-induced otomandibular dysostosis are described; the causal mechanism of malformation appeared to be closely related to the formation of a hematoma at the time of development of the stapedial arterial systems." | 3.65 | Hemorrhage in development of the face. ( Poswillo, D, 1975) |
| " The present review examines the drug's pharmacokinetics, discusses the main adverse renal effects that are associated with lenalidomide treatment, and makes recommendations for dosage adjustment in patients with underlying renal impairment." | 2.53 | [Lenalidomide nephrotoxicity]. ( Izzedine, H; Kheder El-Fekih, R, 2016) |
| " This dosage form permits the prolonged drug release." | 1.39 | Evaluation of the effects of thalidomide-loaded biodegradable devices in solid Ehrlich tumor. ( Dantas Cassali, G; Ligorio Fialho, S; Maria de Souza, C; Pereira, BG; Silva-Cunha, A, 2013) |
| " Rats with implanted liver tumors were randomized into four treatment groups: 1) Zd6126 (Zd); 2) Thalidomide (Tha); 3) Zd in combination with Tha (ZdTha); and 4) controls." | 1.38 | Enhanced antitumor efficacy of a vascular disrupting agent combined with an antiangiogenic in a rat liver tumor model evaluated by multiparametric MRI. ( Chen, F; Cona, MM; De Geest, B; De Keyzer, F; Feng, Y; Jiang, Y; Li, J; Marchal, G; Ni, Y; Oyen, R; Verfaillie, C; Wang, H; Yu, J; Zheng, K, 2012) |
| "Thalidomide-treated group was given thalidomide (10mg/kg/day) intraperitoneally for 10 consecutive days." | 1.32 | Thalidomide salvages lethal hepatic necroinflammation and accelerates recovery from cirrhosis in rats. ( Chen, MF; Ho, YP; Huang, SF; Jan, YY; Yeh, JN; Yeh, TS, 2004) |
| "Thalidomide has no effect on tumor growth, but is also associated with increased VEGF and p53 expression." | 1.31 | Vascular endothelial growth factor monoclonal antibody inhibits growth of anaplastic thyroid cancer xenografts in nude mice. ( Bauer, AJ; Doniparthi, NK; Francis, GL; Patel, A; Ringel, MD; Saji, M; Terrell, R; Tuttle, RM, 2002) |
| "Thalidomide treatment resulted in a significant reduction in tumor necrosis factor-alpha, interleukin 6 (IL-6) and IL-10 protein levels (blood) and mRNA expression (lungs)." | 1.30 | Effect of cytokine modulation by thalidomide on the granulomatous response in murine tuberculosis. ( Freedman, VH; Freeman, S; Kaplan, G; Laochumroonvorapong, P; Moreira, AL; Tsenova-Berkova, L; Wang, J, 1997) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (28.57) | 18.7374 |
| 1990's | 1 (4.76) | 18.2507 |
| 2000's | 6 (28.57) | 29.6817 |
| 2010's | 8 (38.10) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Khammar, Z | 1 |
| Ouazzani, M | 1 |
| Bennani, B | 1 |
| Oubelkacem, N | 1 |
| Berrady, R | 1 |
| Chen, F | 2 |
| De Keyzer, F | 2 |
| Feng, YB | 1 |
| Cona, MM | 2 |
| Yu, J | 2 |
| Marchal, G | 2 |
| Oyen, R | 2 |
| Ni, YC | 1 |
| Kheder El-Fekih, R | 1 |
| Izzedine, H | 1 |
| Li, KD | 1 |
| Salama, ME | 1 |
| Fernández-Martínez, E | 1 |
| Pérez-Hernández, N | 1 |
| Muriel, P | 1 |
| Pérez-Alvarez, V | 1 |
| Shibayama, M | 1 |
| Tsutsumi, V | 1 |
| Cetiner, S | 1 |
| Sucak, GT | 1 |
| Kahraman, SA | 1 |
| Aki, SZ | 1 |
| Kocakahyaoglu, B | 1 |
| Gultekin, SE | 1 |
| Cetiner, M | 1 |
| Haznedar, R | 1 |
| Skamene, S | 1 |
| Rotondo, RL | 1 |
| Shustik, C | 1 |
| Roberge, D | 1 |
| Feng, Y | 2 |
| Zheng, K | 1 |
| Li, J | 1 |
| Wang, H | 1 |
| Jiang, Y | 1 |
| Verfaillie, C | 1 |
| De Geest, B | 1 |
| Ni, Y | 1 |
| Rigual, D | 1 |
| Qiu, J | 1 |
| Fenstermaker, RA | 1 |
| Fabiano, AJ | 1 |
| Pereira, BG | 1 |
| Ligorio Fialho, S | 1 |
| Maria de Souza, C | 1 |
| Dantas Cassali, G | 1 |
| Silva-Cunha, A | 1 |
| Bauer, AJ | 1 |
| Terrell, R | 1 |
| Doniparthi, NK | 1 |
| Patel, A | 1 |
| Tuttle, RM | 1 |
| Saji, M | 1 |
| Ringel, MD | 1 |
| Francis, GL | 1 |
| Staak, JO | 1 |
| Glossmann, JP | 1 |
| Esser, JM | 1 |
| Diehl, V | 1 |
| Mietz, H | 1 |
| Josting, A | 1 |
| RICKENBACHER, J | 1 |
| Friedman, L | 1 |
| Shue, GM | 1 |
| Hove, EL | 1 |
| Yeh, TS | 1 |
| Ho, YP | 1 |
| Huang, SF | 1 |
| Yeh, JN | 1 |
| Jan, YY | 1 |
| Chen, MF | 1 |
| Zhao, D | 1 |
| Jiang, L | 1 |
| Hahn, EW | 1 |
| Mason, RP | 1 |
| Torras, H | 1 |
| Lecha, M | 1 |
| Mascaró/, JM | 1 |
| Moreira, AL | 1 |
| Tsenova-Berkova, L | 1 |
| Wang, J | 1 |
| Laochumroonvorapong, P | 1 |
| Freeman, S | 1 |
| Freedman, VH | 1 |
| Kaplan, G | 1 |
| Rea, TH | 1 |
| Levan, NE | 1 |
| Poswillo, D | 1 |
| Marin-Padilla, M | 1 |
| Benirschke, K | 1 |
2 reviews available for thalidomide and Necrosis
| Article | Year |
|---|---|
[Lenalidomide nephrotoxicity].
Topics: Graft vs Host Disease; Humans; Immunologic Factors; Kidney; Kidney Tubules; Lenalidomide; Necrosis; | 2016 |
Therapy Effect: Impact on Bone Marrow Morphology.
Topics: Antineoplastic Agents; Atrophy; Bone Marrow; Cytokines; Hematologic Neoplasms; Humans; Imatinib Mesy | 2016 |
19 other studies available for thalidomide and Necrosis
| Article | Year |
|---|---|
[Digital ischemia revealing multiple myeloma].
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Bortezomib; Cryoglobulinemia; Dexamethasone; F | 2018 |
Separate calculation of DW-MRI in assessing therapeutic effect in liver tumors in rats.
Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Combined Chemotherapy Protocols; Diffusion Magnetic | 2013 |
The thalidomide analog 3-phthalimido-3-(3,4-dimethoxyphenyl)-propanoic acid improves the biliary cirrhosis in the rat.
Topics: Animals; Fibrosis; Liver Cirrhosis, Biliary; Liver Function Tests; Male; Necrosis; Rats; Rats, Wista | 2009 |
Osteonecrosis of the jaw in patients with multiple myeloma treated with zoledronic acid.
Topics: Adult; Aged; Bone Density Conservation Agents; Bone Resorption; Dexamethasone; Diphosphonates; Femal | 2009 |
Necrosis following skull base irradiation and stem cell transplant for multiple myeloma.
Topics: Antineoplastic Combined Chemotherapy Protocols; Cranial Irradiation; Dexamethasone; Diphosphonates; | 2010 |
Enhanced antitumor efficacy of a vascular disrupting agent combined with an antiangiogenic in a rat liver tumor model evaluated by multiparametric MRI.
Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protoc | 2012 |
Tumoral Bing-Neel Syndrome presenting as a cerebellar mass.
Topics: Anti-Inflammatory Agents; Antibodies, Monoclonal, Murine-Derived; Antineoplastic Agents; Antineoplas | 2013 |
Evaluation of the effects of thalidomide-loaded biodegradable devices in solid Ehrlich tumor.
Topics: Absorbable Implants; Angiogenesis Inducing Agents; Angiogenesis Inhibitors; Animals; Antineoplastic | 2013 |
Vascular endothelial growth factor monoclonal antibody inhibits growth of anaplastic thyroid cancer xenografts in nude mice.
Topics: Angiogenesis Inhibitors; Animals; Antibodies, Monoclonal; Body Weight; Carcinoma; Cell Division; End | 2002 |
Thalidomide for systemic capillary leak syndrome.
Topics: Capillary Leak Syndrome; Capillary Permeability; Compartment Syndromes; Humans; Immunosuppressive Ag | 2003 |
[EXPERIMENTS WITH CONTERGAN IN CHICK EMBRYOS. PRELIMINARY RESULTS].
Topics: Abnormalities, Drug-Induced; Cardiovascular System; Chick Embryo; Ectromelia; Kidney; Liver; Myocard | 1963 |
RESPONSE OF RATS TO THALIDOMIDE AS AFFECTED BY RIBOFLAVIN OR FOLIC ACID DEFICIENCY.
Topics: Amino Acid Oxidoreductases; Avitaminosis; D-Amino-Acid Oxidase; Electron Transport Complex II; Flavi | 1965 |
Thalidomide salvages lethal hepatic necroinflammation and accelerates recovery from cirrhosis in rats.
Topics: Animals; Collagenases; Hepatitis; Kupffer Cells; Liver; Liver Cirrhosis, Experimental; Male; Matrix | 2004 |
Continuous low-dose (metronomic) chemotherapy on rat prostate tumors evaluated using MRI in vivo and comparison with histology.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Area Under Curve; Cyclophosphami | 2005 |
[Thalidomide in the treatment of aphthosis and Behçet's disease. 4 years' experience].
Topics: Adolescent; Adult; Aged; Behcet Syndrome; Drug Evaluation; Female; Humans; Male; Middle Aged; Necros | 1982 |
Effect of cytokine modulation by thalidomide on the granulomatous response in murine tuberculosis.
Topics: Acute Disease; Animals; Apoptosis; Cytokines; Female; Immunosuppressive Agents; Interleukin-10; Inte | 1997 |
Lucio's phenomenon and diffuse nonnodular lepromatous leprosy.
Topics: Adult; Dapsone; Erythema Nodosum; Female; Humans; Ischemia; Leprosy; Lymphopenia; Male; Middle Aged; | 1978 |
Hemorrhage in development of the face.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Animals; Arteries; Craniofacial Dysostosis; Di | 1975 |
Thalidomide injury to the myocardium of armadillo embryos.
Topics: Abnormalities, Drug-Induced; Animals; Embryo, Mammalian; Female; Heart; Myocardium; Necrosis; Pregna | 1965 |