Page last updated: 2024-08-07 17:22:44
P2Y purinoceptor 11
A P2Y purinoceptor 11 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q96G91]
Synonyms
P2Y11
Research
Bioassay Publications (6)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (66.67) | 29.6817 |
| 2010's | 2 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Compounds (10)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| suramin | Homo sapiens (human) | Ki | 0.2071 | 2 | 2 |
Drugs with Activation Measurements
Synthesis and structure-activity relationships of suramin-derived P2Y11 receptor antagonists with nanomolar potency.Journal of medicinal chemistry, , Nov-03, Volume: 48, Issue:22, 2005
Purine and pyrimidine (P2) receptors as drug targets.Journal of medicinal chemistry, , Sep-12, Volume: 45, Issue:19, 2002
Identification of Highly Promising Antioxidants/Neuroprotectants Based on Nucleoside 5'-Phosphorothioate Scaffold. Synthesis, Activity, and Mechanisms of Action.Journal of medicinal chemistry, , Nov-12, Volume: 58, Issue:21, 2015
Highly efficient biocompatible neuroprotectants with dual activity as antioxidants and P2Y receptor agonists.Journal of medicinal chemistry, , Jun-27, Volume: 56, Issue:12, 2013
New iantherans from the marine sponge Ianthella quadrangulata: novel agonists of the P2Y(11) receptor.Journal of medicinal chemistry, , Nov-15, Volume: 50, Issue:23, 2007
Purine and pyrimidine (P2) receptors as drug targets.Journal of medicinal chemistry, , Sep-12, Volume: 45, Issue:19, 2002
Identification of Highly Promising Antioxidants/Neuroprotectants Based on Nucleoside 5'-Phosphorothioate Scaffold. Synthesis, Activity, and Mechanisms of Action.Journal of medicinal chemistry, , Nov-12, Volume: 58, Issue:21, 2015
Purine and pyrimidine (P2) receptors as drug targets.Journal of medicinal chemistry, , Sep-12, Volume: 45, Issue:19, 2002
Enables
This protein enables 3 target(s):
| Target | Category | Definition |
|---|
| neurotransmitter receptor activity | molecular function | Combining with a neurotransmitter and transmitting the signal to initiate a change in cell activity. [GOC:jl, GOC:signaling] |
| signaling receptor activity | molecular function | Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response. [GOC:bf, GOC:signaling] |
| G protein-coupled ATP receptor activity | molecular function | Combining with ATP and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. [GOC:mah] |
Located In
This protein is located in 1 target(s):
| Target | Category | Definition |
|---|
| plasma membrane | cellular component | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363] |
Active In
This protein is active in 1 target(s):
| Target | Category | Definition |
|---|
| plasma membrane | cellular component | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363] |
Involved In
This protein is involved in 8 target(s):
| Target | Category | Definition |
|---|
| defense response | biological process | Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. [GOC:go_curators] |
| G protein-coupled receptor signaling pathway | biological process | The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane. [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor] |
| activation of adenylate cyclase activity | biological process | Any process that initiates the activity of the inactive enzyme adenylate cyclase. [GOC:ai] |
| phospholipase C-activating G protein-coupled receptor signaling pathway | biological process | A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation of phospholipase C (PLC) and a subsequent increase in the intracellular concentration of inositol trisphosphate (IP3) and diacylglycerol (DAG). [GOC:dph, GOC:mah, GOC:signaling, GOC:tb, ISBN:0815316194] |
| calcium-mediated signaling | biological process | Any intracellular signal transduction in which the signal is passed on within the cell via calcium ions. [GOC:signaling] |
| neuronal signal transduction | biological process | The process in which an activated neuronal cell receptor conveys information down a signaling pathway, resulting in a change in the function or state of a cell. This process may be intracellular or intercellular. [GOC:mtg_signal] |
| G protein-coupled purinergic nucleotide receptor signaling pathway | biological process | A G protein-coupled receptor signaling pathway initiated by an extracellular purine nucleotide binding to its receptor, and ending with the regulation of a downstream cellular process. [GOC:BHF, PMID:9755289] |
| cellular response to ATP | biological process | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ATP (adenosine 5'-triphosphate) stimulus. [GOC:mah] |