Fluconazole is a triazole antifungal medication used to treat a variety of fungal infections. It is synthesized through a multi-step process involving the reaction of 1-(2,4-difluorophenyl)-2-(1H-1,2,4-triazol-1-yl)ethanone with 1,3-dichloro-2-propanol. Fluconazole inhibits the enzyme lanosterol 14α-demethylase, which is essential for the biosynthesis of ergosterol, a key component of fungal cell membranes. This inhibition disrupts fungal cell membrane integrity, leading to cell death. Fluconazole is effective against a wide range of fungal species, including Candida, Cryptococcus, Aspergillus, and Blastomyces. It is used to treat systemic fungal infections, such as candidiasis, cryptococcosis, and aspergillosis, as well as superficial infections, such as oral thrush and vaginal yeast infections. Fluconazole is well-absorbed orally and has a long half-life, allowing for once-daily dosing. It is generally well-tolerated, with the most common side effects being headache, nausea, and abdominal pain. Fluconazole is studied extensively due to its broad-spectrum antifungal activity, ease of administration, and favorable safety profile. It is a valuable therapeutic option for a wide range of fungal infections, including those that are resistant to other antifungal agents.'
Fluconazole: Triazole antifungal agent that is used to treat oropharyngeal CANDIDIASIS and cryptococcal MENINGITIS in AIDS. [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
fluconazole : A member of the class of triazoles that is propan-2-ol substituted at position 1 and 3 by 1H-1,2,4-triazol-1-yl groups and at position 2 by a 2,4-difluorophenyl group. It is an antifungal drug used for the treatment of mucosal candidiasis and for systemic infections including systemic candidiasis, coccidioidomycosis, and cryptococcosis. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]
deltarasin: inhibits the interaction between PDEdelta and KRAS protein; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
| ID Source | ID |
|---|---|
| PubMed CID | 3365 |
| CHEMBL ID | 106 |
| CHEBI ID | 46081 |
| SCHEMBL ID | 3151 |
| MeSH ID | M0024111 |
| PubMed CID | 73292904 |
| CHEMBL ID | 3286929 |
| SCHEMBL ID | 15474539 |
| MeSH ID | M0024111 |
| Synonym |
|---|
| MLS001066394 |
| smr000471882 |
| BIDD:GT0799 |
| STK619301 |
| AB00052399-07 |
| AB00052399-08 |
| BRD-K05977355-001-02-6 |
| DIVK1C_001030 |
| KBIO1_001030 |
| fuconal |
| uk-049858 |
| diflazon |
| zoltec |
| loitin |
| 2-(2,4-difluorophenyl)-1,3-di-1h-1,2,4-triazol-1-ylpropan-2-ol |
| fluconazole, >=98% (hplc), powder |
| SPECTRUM_001654 |
| FLC , |
| fluconazole & mc-510,011 |
| SPECTRUM5_001277 |
| IDI1_001030 |
| cid_3365 |
| chembl106 , |
| 2-(2,4-difluorophenyl)-1,3-bis(1h-1,2,4-triazol-1-yl)propan-2-ol |
| bdbm25817 |
| MLS001304713 |
| fluconazole (f) |
| flcz |
| uk-49858 |
| triflucan |
| 2-(2,4-difluorophenyl)-1,3-bis(1,2,4-triazol-1-yl)propan-2-ol |
| .alpha.-(2,4-difluorophenyl)-.alpha.-(1h-1,2,4-triazol-1-ylmethyl)-1h-1,2,4-triazole-1-ethanol |
| diflucan |
| fluconazole & hgcsf |
| fluconazole & human recombinant granulocyte colony stimulating factor |
| flucostat |
| alpha-(2,4-difluorophenyl)-alpha-(1h-1,2,4-triazol-1-ylmethyl)-1h-1,2,4-triazole-1-ethanol |
| biocanol |
| 2-(2,4-difluorophenyl)-1,3-bis(1h-1,2,4-triazol-1-yl)-2-propanol |
| elazor |
| biozolene |
| 2,4-difluoro-alpha,alpha-bis(1h-1,2,4-triazol-1-ylmethyl)benzyl alcohol |
| dimycon |
| flukezol |
| flunizol |
| syscan |
| forcan |
| canzol |
| hsdb 7420 |
| c13h12f2n6o |
| fluconazol [spanish] |
| diflucan in sodium chloride 0.9% in plastic container |
| zonal |
| fluconazolum [latin] |
| drg-0005 |
| alflucoz |
| pritenzol |
| cryptal |
| baten |
| mutum |
| ccris 7211 |
| oxifugol |
| diflucan in dextrose 5% in plastic container |
| flucazol |
| 1h-1,2,4-triazole-1-ethanol, alpha-(2,4-difluorophenyl)-alpha-(1h-1,2,4-triazol-1-ylmethyl)- |
| diflucan in sodium chloride 0.9% |
| uk 49858 |
| zemyc |
| fungata |
| fluconazole |
| C07002 |
| 86386-73-4 |
| 2-(2,4-difluorophenyl)-1,3-di(1h-1,2,4-triazol-1-yl)propan-2-ol |
| fluconazolum |
| fluconazol |
| CHEBI:46081 , |
| DB00196 |
| 2-(2,4-difluoro-phenyl)-1,3-bis-[1,2,4]triazol-1-yl-propan-2-ol |
| difluconazole |
| diflucan (tn) |
| D00322 |
| fluconazole (jp17/usp/inn) |
| NCGC00095089-04 |
| NCGC00095089-02 |
| NCGC00095089-01 |
| KBIO3_003009 |
| KBIOSS_002134 |
| KBIO2_007270 |
| KBIO2_002134 |
| KBIO2_004702 |
| KBIOGR_000360 |
| SPECTRUM3_001912 |
| SPECTRUM4_000090 |
| SPBIO_001613 |
| NINDS_001030 |
| SPECTRUM2_001607 |
| SPECTRUM1503975 |
| BSPBIO_003504 |
| NCGC00095089-05 |
| MLS001306492 |
| MLS001165780 |
| MLS001195645 |
| mgcd290 and fluconazole |
| mg-3290 and fluconazole |
| fluconazole in combination with mgcd290 |
| AC-428 |
| HMS2093M21 |
| HMS2090I20 |
| F0677 , |
| AKOS000280854 |
| fluconazoli |
| uk-49,858 |
| alkanazole |
| bayt-006267 |
| nsc-758661 |
| bayt006267 |
| HMS503M21 |
| HMS1922O10 |
| A841625 |
| 2-(2,4-difluorophenyl)-1,3-bis(1,2,4-triazol-1-yl)-2-propanol |
| 2-[2,4-bis(fluoranyl)phenyl]-1,3-bis(1,2,4-triazol-1-yl)propan-2-ol |
| NCGC00095089-07 |
| NCGC00095089-09 |
| NCGC00095089-08 |
| NCGC00095089-06 |
| HMS3259H13 |
| EN300-53634 |
| fluzon [antifungal] |
| triconal |
| nsc 758661 |
| flunazol |
| fluconazole [usan:usp:inn:ban:jan] |
| fluconazole in sodium chloride 0.9% in plastic container |
| fluconazole in sodium chloride 0.9% |
| 8vzv102jfy , |
| unii-8vzv102jfy |
| fluconazole in dextrose 5% in plastic container |
| NCGC00259789-01 |
| NCGC00254412-01 |
| tox21_202240 |
| tox21_300581 |
| BBL005614 |
| pharmakon1600-01503975 |
| fluconazole [usan] |
| nsc758661 |
| dtxsid3020627 , |
| dtxcid10627 |
| tox21_111419 |
| cas-86386-73-4 |
| trican |
| 123631-92-5 |
| HMS2230O22 |
| CCG-39065 |
| BRD-K05977355-001-09-1 |
| FT-0626437 |
| NCGC00095089-11 |
| S1331 |
| HMS3373I19 |
| fluconazole [jan] |
| fluconazole [usp monograph] |
| fluconazole [mart.] |
| fluconazole [vandf] |
| 2,4-difluoro-1',1'-bis(1h-1,2,4-triazol-1-ylmethyl)benzyl alcohol |
| fluconazole [usp-rs] |
| fluconazole [who-ip] |
| 1h-1,2,4-triazole-1-ethanol, 1-(2,4-difluorophenyl)-1-(1h-1,2,4-triazol-1-ylmethyl)- |
| fluconazole [inn] |
| fluconazole [who-dd] |
| fluconazole [mi] |
| fluconazoli [who-ip latin] |
| fluconazole [orange book] |
| fluconazole [ep monograph] |
| fluconazole [hsdb] |
| DL-407 |
| HY-B0101 |
| CS-1835 |
| NC00650 |
| SCHEMBL3151 |
| tox21_111419_1 |
| NCGC00095089-10 |
| KS-1059 , |
| F2173-0496 |
| MLS006011884 |
| Q-201120 |
| AB00052399_10 |
| AB00052399_09 |
| mfcd00274549 |
| SR-01000765440-4 |
| SR-01000765440-2 |
| SR-01000765440-8 |
| sr-01000765440 |
| fluconazole, united states pharmacopeia (usp) reference standard |
| HMS3654P15 |
| fluconazole, european pharmacopoeia (ep) reference standard |
| fluconazole, pharmaceutical secondary standard; certified reference material |
| fluconazole for peak identification, european pharmacopoeia (ep) reference standard |
| Z235354561 |
| fluconazole 2.0 mg/ml in methanol |
| SBI-0051880.P002 |
| HMS3715F21 |
| SW199616-2 |
| Q411478 |
| 2-(2,4-difluorophenyl)-1,3-di(1h- |
| 1,2,4-triazol-1-yl)propan-2-ol |
| fluconazole,(s) |
| fluconazole 100 microg/ml in acetonitrile |
| BCP28522 |
| uk-49858;uk 49858;uk49858 |
| AMY23415 |
| 2-(2,4-difluorfenyl)-1,3-bis(1h-1,2,4-triazool-1-yl)propaan-2-ol |
| HMS3748G19 |
| flucoral |
| a-(2,4-difluorophenyl)-a-(1h-1,2,4-triazol-1- ylmethyl)-1h-1,2,4-triazole-1-ethanol |
| nsc754343 |
| nsc-754343 |
| fluconazole- bio-x |
| BF164466 |
| 1h-1,2,4-triazole-1-ethanol, .alpha.-(2,4-difluorophenyl)-.alpha.-(1h-1,2,4-triazol-1-ylmethyl)- |
| af01 - antifungals |
| fluconazole (usp monograph) |
| fluconazole, sodium chloride |
| fluconazole (usp-rs) |
| expel-f |
| j02ac01 |
| d01ac15 |
| fluzon (antifungal) |
| fluconazole (usan:usp:inn:ban:jan) |
| fluconazole (ep monograph) |
| biozole |
| fluconazole (mart.) |
| fluconazole in sodium chloride |
| fluconazolo |
| fluconazolum (latin) |
| bdbm50019865 |
| chembl3286929 , |
| S7224 |
| deltarasin |
| HY-15747 |
| CS-1611 |
| 1440898-61-2 |
| 1440898-82-7 |
| SCHEMBL15474539 |
| AC-32917 |
| J-690178 |
| EX-A1042 |
| AKOS030526539 |
| 1-benzyl-2-{4-[(2s)-2-(2-phenyl-1h-1,3-benzodiazol-1-yl)-2-(piperidin-4-yl)ethoxy]phenyl}-1h-1,3-benzodiazole |
| (s)-1-benzyl-2-(4-(2-(2-phenyl-1h-benzo[d]imidazol-1-yl)-2-(piperidin-4-yl)ethoxy)phenyl)-1h-benzo[d]imidazole |
| 1-[(1s)-2-[4-(1-benzyl-1h-1,3-benzodiazol-2-yl)phenoxy]-1-(piperidin-4-yl)ethyl]-2-phenyl-1h-1,3-benzodiazole |
| mfcd26793865 |
| SW219816-1 |
| BCP20971 |
| CCG-270204 |
| MS-30649 |
| 1-benzyl-2-[4-[(2s)-2-(2-phenylbenzimidazol-1-yl)-2-piperidin-4-ylethoxy]phenyl]benzimidazole |
| nsc779408 |
| nsc-779408 |
| NCGC00378602-10 |
| O7T , |
Fluconazole (FLZ) is a broad-spectrum antifungal used against Candida infections. It is an alternative treatment especially in Cushing's disease patients with cryptococcal pneumonia. Flu Conazole is a safe, effective, and feasible strategy to prevent IC in a Latin American country.
Fluconazole has a lower propensity to interact with rat hepatic cytochrome P-450. Its in vivo antifungal potency is an order of magnitude greater than ketoconazole. Oral fluconazol has a more significant impact on its drug interactions with tacrolimus.
Fluconazole has a broad spectrum antifungal activity including a wide variety of candida species. It has poor complexing ability (Ka of 34 M(-1) with HPβCD-PAA); thus, it was only tested as a physical mixture.
Fluconazole has a lower propensity to interact with rat hepatic cytochrome P-450 and can be considered a more selective antifungal agent. Its in vivo antif fungus potency is an order of magnitude greater than ketoconazole.
Fluconazole-initiated treatment followed by caspofungin was cost-effective for the treatment of IC/C. The amount of ergosterol and its precursors remain comparable in all three strains tested.
Fluconazole appears to be safe to use in this population, with only minimal reversible hepatobiliary effects. No adverse events were thought to be related to flu Conazole therapy.
Recent studies suggest that fluconazole pharmacodynamic parameters correlate with clinical outcomes. Additional data of correlation to mortality in patients with candidemia would be valuable.
The antifungal activity of retigeric acid B (RAB), a pentacyclic triterpenoid from the lichen species Lobaria kurokawae, was evaluated alone and in combination with fluconazole. Silver nanoparticles synthesized using a green route are efficiently used to inhibit growth of C. albicans.
Fluconazole and itraconazole are widely used in chemoprophylaxis because of their favourable oral bioavailability and safety profiles. The development of new azoles with a better ocular bioavailability has recently influenced the treatment of fungal endophthalmitis.
The present study aimed to evaluate different dosage forms, emulsions, emulgels, lipogels, and thickened microemulsion-based hydrogel. Fluconazol may be preferred in patients unable to tolerate other oral antifungal agents due to the dosing regimen.
| Role | Description |
|---|---|
| P450 inhibitor | An enzyme inhibitor that interferes with the activity of cytochrome P450 involved in catalysis of organic substances. |
| environmental contaminant | Any minor or unwanted substance introduced into the environment that can have undesired effects. |
| xenobiotic | A xenobiotic (Greek, xenos "foreign"; bios "life") is a compound that is foreign to a living organism. Principal xenobiotics include: drugs, carcinogens and various compounds that have been introduced into the environment by artificial means. |
| [role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] | |
| Class | Description |
|---|---|
| tertiary alcohol | A tertiary alcohol is a compound in which a hydroxy group, -OH, is attached to a saturated carbon atom which has three other carbon atoms attached to it. |
| difluorobenzene | Any member of the class of fluorobenzenes containing a mono- or poly-substituted benzene ring carrying two fluorine atoms. |
| conazole antifungal drug | Any conazole antifungal agent that has been used for the treatment of fungal infections in animals or humans. |
| triazole antifungal drug | Any triazole antifungal agent that has been used for the treatment of fungal infections in humans or animals. |
| [compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] | |
| Pathway | Proteins | Compounds |
|---|---|---|
| Signaling Pathways | 1269 | 117 |
| MAPK family signaling cascades | 115 | 19 |
| ERK1/ERK2 pathway | 93 | 19 |
| RAF/MAP kinase cascade | 91 | 19 |
| RAS processing | 13 | 18 |
| Protein | Taxonomy | Measurement | Average (µ) | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| acetylcholinesterase | Homo sapiens (human) | Potency | 101.2440 | 0.0025 | 41.7960 | 15,848.9004 | AID1347395 |
| GLI family zinc finger 3 | Homo sapiens (human) | Potency | 0.2189 | 0.0007 | 14.5928 | 83.7951 | AID1259369 |
| apical membrane antigen 1, AMA1 | Plasmodium falciparum 3D7 | Potency | 3.1623 | 0.7079 | 12.1943 | 39.8107 | AID720542 |
| cytochrome P450 family 3 subfamily A polypeptide 4 | Homo sapiens (human) | Potency | 12.3018 | 0.0123 | 7.9835 | 43.2770 | AID1645841 |
| glucocorticoid receptor [Homo sapiens] | Homo sapiens (human) | Potency | 1.2300 | 0.0002 | 14.3764 | 60.0339 | AID720692 |
| retinoic acid nuclear receptor alpha variant 1 | Homo sapiens (human) | Potency | 69.2179 | 0.0030 | 41.6115 | 22,387.1992 | AID1159552 |
| retinoid X nuclear receptor alpha | Homo sapiens (human) | Potency | 36.9771 | 0.0008 | 17.5051 | 59.3239 | AID1159527; AID1159531 |
| pregnane X nuclear receptor | Homo sapiens (human) | Potency | 31.6228 | 0.0054 | 28.0263 | 1,258.9301 | AID720659 |
| estrogen nuclear receptor alpha | Homo sapiens (human) | Potency | 39.1184 | 0.0002 | 29.3054 | 16,493.5996 | AID743069; AID743078 |
| G | Vesicular stomatitis virus | Potency | 10.9640 | 0.0123 | 8.9648 | 39.8107 | AID1645842 |
| cytochrome P450 2D6 | Homo sapiens (human) | Potency | 13.8029 | 0.0010 | 8.3798 | 61.1304 | AID1645840 |
| chromobox protein homolog 1 | Homo sapiens (human) | Potency | 100.0000 | 0.0060 | 26.1688 | 89.1251 | AID540317 |
| transcriptional regulator ERG isoform 3 | Homo sapiens (human) | Potency | 11.2202 | 0.7943 | 21.2757 | 50.1187 | AID624246 |
| DNA polymerase iota isoform a (long) | Homo sapiens (human) | Potency | 89.1251 | 0.0501 | 27.0736 | 89.1251 | AID588590 |
| geminin | Homo sapiens (human) | Potency | 0.8913 | 0.0046 | 11.3741 | 33.4983 | AID624297 |
| cytochrome P450 3A4 isoform 1 | Homo sapiens (human) | Potency | 39.8107 | 0.0316 | 10.2792 | 39.8107 | AID884; AID885 |
| lamin isoform A-delta10 | Homo sapiens (human) | Potency | 0.5012 | 0.8913 | 12.0676 | 28.1838 | AID1487 |
| Gamma-aminobutyric acid receptor subunit pi | Rattus norvegicus (Norway rat) | Potency | 39.8107 | 1.0000 | 12.2248 | 31.6228 | AID885 |
| Rap guanine nucleotide exchange factor 3 | Homo sapiens (human) | Potency | 100.0000 | 6.3096 | 60.2008 | 112.2020 | AID720709 |
| Interferon beta | Homo sapiens (human) | Potency | 10.9640 | 0.0033 | 9.1582 | 39.8107 | AID1645842 |
| HLA class I histocompatibility antigen, B alpha chain | Homo sapiens (human) | Potency | 10.9640 | 0.0123 | 8.9648 | 39.8107 | AID1645842 |
| Cellular tumor antigen p53 | Homo sapiens (human) | Potency | 38.9241 | 0.0023 | 19.5956 | 74.0614 | AID651631 |
| Gamma-aminobutyric acid receptor subunit beta-1 | Rattus norvegicus (Norway rat) | Potency | 39.8107 | 1.0000 | 12.2248 | 31.6228 | AID885 |
| Gamma-aminobutyric acid receptor subunit delta | Rattus norvegicus (Norway rat) | Potency | 39.8107 | 1.0000 | 12.2248 | 31.6228 | AID885 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | Rattus norvegicus (Norway rat) | Potency | 39.8107 | 1.0000 | 12.2248 | 31.6228 | AID885 |
| Gamma-aminobutyric acid receptor subunit alpha-5 | Rattus norvegicus (Norway rat) | Potency | 39.8107 | 1.0000 | 12.2248 | 31.6228 | AID885 |
| Gamma-aminobutyric acid receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | Potency | 39.8107 | 1.0000 | 12.2248 | 31.6228 | AID885 |
| Gamma-aminobutyric acid receptor subunit gamma-1 | Rattus norvegicus (Norway rat) | Potency | 39.8107 | 1.0000 | 12.2248 | 31.6228 | AID885 |
| Gamma-aminobutyric acid receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | Potency | 39.8107 | 1.0000 | 12.2248 | 31.6228 | AID885 |
| Gamma-aminobutyric acid receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | Potency | 39.8107 | 1.0000 | 12.2248 | 31.6228 | AID885 |
| Gamma-aminobutyric acid receptor subunit gamma-3 | Rattus norvegicus (Norway rat) | Potency | 39.8107 | 1.0000 | 12.2248 | 31.6228 | AID885 |
| Gamma-aminobutyric acid receptor subunit alpha-6 | Rattus norvegicus (Norway rat) | Potency | 39.8107 | 1.0000 | 12.2248 | 31.6228 | AID885 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Rattus norvegicus (Norway rat) | Potency | 39.8107 | 1.0000 | 12.2248 | 31.6228 | AID885 |
| Gamma-aminobutyric acid receptor subunit beta-3 | Rattus norvegicus (Norway rat) | Potency | 39.8107 | 1.0000 | 12.2248 | 31.6228 | AID885 |
| Gamma-aminobutyric acid receptor subunit beta-2 | Rattus norvegicus (Norway rat) | Potency | 39.8107 | 1.0000 | 12.2248 | 31.6228 | AID885 |
| TAR DNA-binding protein 43 | Homo sapiens (human) | Potency | 11.2202 | 1.7783 | 16.2081 | 35.4813 | AID652104 |
| GABA theta subunit | Rattus norvegicus (Norway rat) | Potency | 39.8107 | 1.0000 | 12.2248 | 31.6228 | AID885 |
| Inositol hexakisphosphate kinase 1 | Homo sapiens (human) | Potency | 10.9640 | 0.0123 | 8.9648 | 39.8107 | AID1645842 |
| Gamma-aminobutyric acid receptor subunit epsilon | Rattus norvegicus (Norway rat) | Potency | 39.8107 | 1.0000 | 12.2248 | 31.6228 | AID885 |
| cytochrome P450 2C9, partial | Homo sapiens (human) | Potency | 10.9640 | 0.0123 | 8.9648 | 39.8107 | AID1645842 |
| cytochrome P450 family 3 subfamily A polypeptide 4 | Homo sapiens (human) | Potency | 2.6837 | 0.0123 | 7.9835 | 43.2770 | AID1645841 |
| G | Vesicular stomatitis virus | Potency | 30.1116 | 0.0123 | 8.9648 | 39.8107 | AID1645842 |
| cytochrome P450 2D6 | Homo sapiens (human) | Potency | 11.9877 | 0.0010 | 8.3798 | 61.1304 | AID1645840 |
| Interferon beta | Homo sapiens (human) | Potency | 30.1116 | 0.0033 | 9.1582 | 39.8107 | AID1645842 |
| HLA class I histocompatibility antigen, B alpha chain | Homo sapiens (human) | Potency | 30.1116 | 0.0123 | 8.9648 | 39.8107 | AID1645842 |
| Inositol hexakisphosphate kinase 1 | Homo sapiens (human) | Potency | 30.1116 | 0.0123 | 8.9648 | 39.8107 | AID1645842 |
| cytochrome P450 2C9, partial | Homo sapiens (human) | Potency | 30.1116 | 0.0123 | 8.9648 | 39.8107 | AID1645842 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
| Protein | Taxonomy | Measurement | Average | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| Histone deacetylase 3 | Homo sapiens (human) | IC50 (µMol) | 40.0000 | 0.0004 | 0.6196 | 10.0000 | AID1549163 |
| ATP-binding cassette sub-family C member 3 | Homo sapiens (human) | IC50 (µMol) | 133.0000 | 0.6315 | 4.4531 | 9.3000 | AID1473740 |
| Multidrug resistance-associated protein 4 | Homo sapiens (human) | IC50 (µMol) | 133.0000 | 0.2000 | 5.6774 | 10.0000 | AID1473741 |
| Bile salt export pump | Homo sapiens (human) | IC50 (µMol) | 133.0000 | 0.1100 | 7.1903 | 10.0000 | AID1473738 |
| Chymotrypsinogen A | Bos taurus (cattle) | IC50 (µMol) | 400.0000 | 0.9800 | 4.0560 | 7.2000 | AID52776 |
| Beta-lactamase | Escherichia coli K-12 | IC50 (µMol) | 400.0000 | 0.0150 | 2.4657 | 8.0000 | AID43431 |
| Steroid 17-alpha-hydroxylase/17,20 lyase | Homo sapiens (human) | IC50 (µMol) | 200.0000 | 0.0020 | 0.9818 | 4.7300 | AID1487223; AID1487224 |
| Heme oxygenase 1 | Rattus norvegicus (Norway rat) | IC50 (µMol) | 90.0000 | 1.1000 | 4.3200 | 10.0000 | AID1799166 |
| ATP-dependent translocase ABCB1 | Mus musculus (house mouse) | Ki | 1,000.0000 | 3.5000 | 5.6067 | 6.9300 | AID681138 |
| ATP-dependent translocase ABCB1 | Homo sapiens (human) | Ki | 700.0000 | 0.0200 | 2.3594 | 8.5900 | AID681142; AID681143 |
| Cytochrome P450 3A4 | Homo sapiens (human) | IC50 (µMol) | 26.4933 | 0.0001 | 1.7536 | 10.0000 | AID1487215; AID1557089; AID1634154; AID428564 |
| Lanosterol 14-alpha demethylase | Candida albicans SC5314 | IC50 (µMol) | 0.1296 | 0.1100 | 0.1296 | 0.1480 | AID1728522; AID1818293; AID1864908; AID1888278; AID1918342 |
| Aromatase | Homo sapiens (human) | IC50 (µMol) | 22.0000 | 0.0000 | 1.2904 | 10.0000 | AID1487225 |
| Cytochrome P450 2C9 | Homo sapiens (human) | IC50 (µMol) | 18.7367 | 0.0000 | 2.8005 | 10.0000 | AID1310920; AID1487219; AID1487220 |
| Cytochrome P450 11B1, mitochondrial | Homo sapiens (human) | IC50 (µMol) | 30.0000 | 0.0005 | 0.2902 | 2.7800 | AID1487221 |
| Cytochrome P450 11B2, mitochondrial | Homo sapiens (human) | IC50 (µMol) | 13.0000 | 0.0001 | 0.2738 | 3.5000 | AID1487222 |
| ATP-dependent translocase ABCB1 | Mus musculus (house mouse) | Ki | 1,000.0000 | 2.1000 | 4.3150 | 7.4800 | AID681137 |
| Heme oxygenase 2 | Rattus norvegicus (Norway rat) | IC50 (µMol) | 90.0000 | 1.1000 | 4.4833 | 10.0000 | AID1799166 |
| Histone deacetylase 4 | Homo sapiens (human) | IC50 (µMol) | 40.0000 | 0.0006 | 1.0526 | 10.0000 | AID1549163 |
| Histone deacetylase 1 | Homo sapiens (human) | IC50 (µMol) | 40.0000 | 0.0001 | 0.5543 | 9.9000 | AID1549163 |
| Lanosterol 14-alpha demethylase | Homo sapiens (human) | IC50 (µMol) | 200.0000 | 0.0500 | 1.4390 | 4.0000 | AID322753 |
| Sterol 14-alpha demethylase | Trypanosoma cruzi strain CL Brener | IC50 (µMol) | 0.8800 | 0.0010 | 1.7070 | 10.0000 | AID1383443 |
| Histone deacetylase 7 | Homo sapiens (human) | IC50 (µMol) | 40.0000 | 0.0007 | 1.0260 | 9.9000 | AID1549163 |
| Histone deacetylase 2 | Homo sapiens (human) | IC50 (µMol) | 40.0000 | 0.0001 | 0.7221 | 9.9700 | AID1549163 |
| Canalicular multispecific organic anion transporter 1 | Homo sapiens (human) | IC50 (µMol) | 133.0000 | 2.4100 | 6.3433 | 10.0000 | AID1473739 |
| Polyamine deacetylase HDAC10 | Homo sapiens (human) | IC50 (µMol) | 40.0000 | 0.0005 | 0.7245 | 9.9000 | AID1549163 |
| Histone deacetylase 11 | Homo sapiens (human) | IC50 (µMol) | 40.0000 | 0.0003 | 0.9298 | 9.9000 | AID1549163 |
| Histone deacetylase 8 | Homo sapiens (human) | IC50 (µMol) | 40.0000 | 0.0007 | 0.9947 | 9.9000 | AID1549163 |
| Histone deacetylase 6 | Homo sapiens (human) | IC50 (µMol) | 40.0000 | 0.0000 | 0.5376 | 9.9000 | AID1549163 |
| Histone deacetylase 9 | Homo sapiens (human) | IC50 (µMol) | 40.0000 | 0.0005 | 0.9413 | 9.9000 | AID1549163 |
| Histone deacetylase 5 | Homo sapiens (human) | IC50 (µMol) | 40.0000 | 0.0007 | 0.9610 | 10.0000 | AID1549163 |
| likely tRNA 2'-phosphotransferase | Candida albicans SC5314 | IC50 (µMol) | 49.7510 | 0.0419 | 0.2913 | 0.5407 | AID2838 |
| Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta | Homo sapiens (human) | IC50 (µMol) | 0.0210 | 0.0005 | 1.1353 | 5.2000 | AID1612787 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
| Protein | Taxonomy | Measurement | Average | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| Chain A, BCL-2-RELATED PROTEIN A1 | Homo sapiens (human) | EC50 (µMol) | 350.0000 | 8.0570 | 121.1218 | 338.0000 | AID2765 |
| bcl-2-like protein 11 isoform 1 | Homo sapiens (human) | EC50 (µMol) | 350.0000 | 8.0570 | 121.1218 | 338.0000 | AID2765 |
| Lanosterol 14-alpha demethylase | Candida albicans SC5314 | Kd | 0.0450 | 0.0450 | 0.0970 | 0.1650 | AID575761 |
| Cytochrome P450 144 | Mycobacterium tuberculosis CDC1551 | Kd | 451.5500 | 0.3600 | 2.5990 | 5.3000 | AID1799791 |
| Steroid C26-monooxygenase | Mycobacterium tuberculosis CDC1551 | Kd | 451.5500 | 0.1000 | 2.5967 | 6.1000 | AID1799791 |
| Steroid C26-monooxygenase | Mycobacterium tuberculosis CDC1551 | Kd | 451.5500 | 0.3600 | 2.5990 | 5.3000 | AID1799791 |
| Mycocyclosin synthase | Mycobacterium tuberculosis H37Rv | Kd | 6.0000 | 0.0730 | 1.5547 | 6.0000 | AID572703 |
| Lanosterol 14-alpha demethylase | Mycobacterium tuberculosis H37Rv | Kd | 33.4000 | 0.2000 | 0.4200 | 1.3000 | AID351877; AID351882; AID572699 |
| Lanosterol 14-alpha demethylase | Homo sapiens (human) | Kd | 76.6667 | 0.1100 | 2.7400 | 8.0000 | AID322375; AID322755; AID572704 |
| Sterol 14-alpha demethylase | Aspergillus fumigatus Af293 | Kd | 11.9300 | 1.0100 | 3.0300 | 4.7900 | AID575747 |
| Sterol 14-alpha demethylase | Trypanosoma cruzi strain CL Brener | Kd | 0.2575 | 0.0180 | 0.4285 | 2.3000 | AID1165098; AID1196810; AID1799528 |
| 14-alpha sterol demethylase | Aspergillus fumigatus | Kd | 4.0300 | 0.0310 | 0.8482 | 4.0300 | AID575748 |
| Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta | Homo sapiens (human) | Kd | 0.0183 | 0.0011 | 0.8485 | 2.9000 | AID1154661; AID1475929; AID1612792; AID1658929 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
| Protein | Taxonomy | Measurement | Average | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| heat shock protein HSP 90-alpha isoform 2 | Homo sapiens (human) | AC50 | 4.6870 | 0.1950 | 3.6679 | 18.6960 | AID540270 |
| heat shock protein 90, putative | Plasmodium falciparum 3D7 | AC50 | 2.7210 | 0.1950 | 4.9920 | 98.5000 | AID540268 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID1272752 | Antifungal activity against Penicillium citrinum at 0.06 mol/L after 2 to 4 days by paper disc method | 2016 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 26, Issue:3 | Synthesis, antimicrobial activity of Schiff base compounds of cinnamaldehyde and amino acids. |
| AID55030 | Evaluation of In vitro antifungal activity against Cryptococcus neoformans 87 by broth macro dilution method | 1995 | Journal of medicinal chemistry, Sep-29, Volume: 38, Issue:20 | Synthesis and antifungal activity of new azole derivatives containing an N-acylmorpholine ring. |
| AID776436 | Antifungal activity against Candida albicans ATCC 26555 after 24 hrs by microdilution technique | 2013 | European journal of medicinal chemistry, Nov, Volume: 69 | Synthesis, antimicrobial, antioxidant activities of novel 6-aryl-5-cyano thiouracil derivatives. |
| AID1624168 | Antifungal activity against Candida albicans NR-29449 after 24 hrs by microbroth dilution method | 2019 | Bioorganic & medicinal chemistry letters, 03-01, Volume: 29, Issue:5 | Benzimidazole tethered pyrrolo[3,4-b]quinoline with broad-spectrum activity against fungal pathogens. |
| AID1762388 | Antifungal activity against Candida albicans ATCC 90028 assessed as reduction in microbial growth after 36 hrs by resazurin dye based assay | 2021 | Bioorganic & medicinal chemistry, 05-15, Volume: 38 | Repurposing primaquine as a polyamine conjugate to become an antibiotic adjuvant. |
| AID1903360 | Antifungal activity against fluconazole resistant Cryptococcus neoformans ATCC 32719 assessed as reduction in fungal growth incubated for 24 hrs by two fold broth dilution method | 2022 | European journal of medicinal chemistry, Apr-05, Volume: 233 | Design, synthesis, and biological evaluation of novel spiro[pyrrolidine-2,3'-quinolin]-2'-one derivatives as potential chitin synthase inhibitors and antifungal agents. |
| AID1904288 | Inhibition of Cryptococcus neoformans H99 delta5,6-desaturase assessed as upregulation of ERG4 gene expression at 2 ug/ml incubated for 24 hrs by RT-PCR analysis | 2022 | Journal of medicinal chemistry, 05-12, Volume: 65, Issue:9 | Discovery of Novel Sertraline Derivatives as Potent Anti- |
| AID1510725 | Antibacterial activity against Bacillus subtilis | 2019 | European journal of medicinal chemistry, Oct-01, Volume: 179 | Nitroimidazole-containing compounds and their antibacterial and antitubercular activities. |
| AID521493 | Antifungal activity against Candida albicans ATCC 24433 after 48 hrs by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | In vitro and in vivo antifungal activities of T-2307, a novel arylamidine. |
| AID542090 | Antifungal activity against Candida parapsilosis IFO1396 after 24 hrs by microdilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Discovery of a small-molecule inhibitor of {beta}-1,6-glucan synthesis. |
| AID1199854 | Inhibition of Vps75-stimulated recombinant Saccharomyces cerevisiae histone acetyltransferase Rtt109 using [3H]-acetyl-CoA assessed as acetate incorporation after 30 mins by liquid scintillation counting | 2015 | Journal of medicinal chemistry, Mar-12, Volume: 58, Issue:5 | PAINS in the assay: chemical mechanisms of assay interference and promiscuous enzymatic inhibition observed during a sulfhydryl-scavenging HTS. |
| AID1890304 | Antifungal activity against Mucor circinelloides M5 strain assessed as complete absence of mycelia at 100 to 150 ug/ml by microscopic analysis | 2022 | Bioorganic & medicinal chemistry letters, 05-01, Volume: 63 | Novel 2-aryl-4-aryloxyquinoline-based fungistatics for Mucor circinelloides. Biological evaluation of activity, QSAR and docking study. |
| AID1193494 | Thermodynamic equilibrium solubility, log S of the compound in simulated gastric fluid at pH 1.2 at RT after 4 hrs by 96 well plate method | 2015 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 25, Issue:7 | Thermodynamic equilibrium solubility measurements in simulated fluids by 96-well plate method in early drug discovery. |
| AID1737524 | Antifungal activity against Aspergillus flavus ATCC 16870 incubated for 48 hrs by two-fold broth dilution analysis | 2020 | European journal of medicinal chemistry, Jun-01, Volume: 195 | Design, synthesis and biological evaluation of novel 3,4-dihydro-2(1H)-quinolinone derivatives as potential chitin synthase inhibitors and antifungal agents. |
| AID300440 | Antifungal activity against Candida albicans ATCC 90028 after 48 hrs by broth microdilution test | 2007 | Bioorganic & medicinal chemistry, Sep-01, Volume: 15, Issue:17 | 1-Acylthiosemicarbazides, 1,2,4-triazole-5(4H)-thiones, 1,3,4-thiadiazoles and hydrazones containing 5-methyl-2-benzoxazolinones: synthesis, analgesic-anti-inflammatory and antimicrobial activities. |
| AID569364 | Antifungal activity against Aspergillus niger at 1000 ug after 24 hrs by paper disc technique | 2011 | European journal of medicinal chemistry, Feb, Volume: 46, Issue:2 | Efficient and novel one-pot synthesis of antifungal active 1-substituted-8-aryl-3-alkyl/aryl-4H-pyrazolo[4,5-f][1,2,4]triazolo[4,3-b][1,2,4]triazepines using solid support. |
| AID526818 | Octanol-phosphate buffer partition coefficient, log D of the compound at pH 7.4 | 2010 | Bioorganic & medicinal chemistry, Nov-01, Volume: 18, Issue:21 | 1,3-Benzoxazole-4-carbonitrile as a novel antifungal scaffold of β-1,6-glucan synthesis inhibitors. |
| AID545271 | Antifungal activity against Candida krusei E28 after 48 hrs by broth microdilution method | 2010 | European journal of medicinal chemistry, Dec, Volume: 45, Issue:12 | New amino acid esters of salicylanilides active against MDR-TB and other microbes. |
| AID765553 | Antimicrobial activity against Saccharomyces cerevisiae RSKK 251 after 18 to 24 hrs by double microdilution method | 2013 | European journal of medicinal chemistry, Sep, Volume: 67 | Microwave assisted synthesis of some hybrid molecules derived from norfloxacin and investigation of their biological activities. |
| AID772317 | Antifungal activity against fluconazole-resistant Candida glabrata DSY2271 increase expressing of CgCDR2 genes after 24 hrs by visually and spectrophotometric analysis | 2013 | ACS medicinal chemistry letters, Sep-12, Volume: 4, Issue:9 | Novel Macrocyclic Amidinoureas: Potent Non-Azole Antifungals Active against Wild-Type and Resistant Candida Species. |
| AID531541 | Antifungal activity against Candida glabrata clinical isolate obtained from vulvovaginal candidiasis patient assessed as resistant isolates by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Antifungal resistance of Candida glabrata vaginal isolates and development of a quantitative reverse transcription-PCR-based azole susceptibility assay. |
| AID717786 | Antimicrobial activity against Candida albicans ATCC 44859 after 48 hrs by broth microdilution test | 2012 | Bioorganic & medicinal chemistry, Dec-15, Volume: 20, Issue:24 | Contribution to investigation of antimicrobial activity of styrylquinolines. |
| AID717772 | Antimicrobial activity against Trichophyton mentagrophytes 445 after 120 hrs by broth microdilution test | 2012 | Bioorganic & medicinal chemistry, Dec-15, Volume: 20, Issue:24 | Contribution to investigation of antimicrobial activity of styrylquinolines. |
| AID1728513 | Inhibition of CYP51 in Candida albicans ATCC SC5314 assessed as lanosterol level at 0.5 ug/ml incubated for 48 hrs by LC/MS analysis | 2021 | European journal of medicinal chemistry, Jan-15, Volume: 210 | Novel naphthylamide derivatives as dual-target antifungal inhibitors: Design, synthesis and biological evaluation. |
| AID521521 | Antifungal activity against Trichophyton rubrum NBRC 5467 after 72 hrs by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | In vitro and in vivo antifungal activities of T-2307, a novel arylamidine. |
| AID1550454 | Antifungal activity against Candida albicans ATCC 90028 assessed as decrease in fungal cell growth incubated for 24 hrs by E-test | 2019 | European journal of medicinal chemistry, Jun-01, Volume: 171 | Antimicrobial and KPC/AmpC inhibitory activity of functionalized benzosiloxaboroles. |
| AID480476 | Antifungal activity against Candida parapsilosis after 24 hrs by serial dilution method | 2010 | Bioorganic & medicinal chemistry letters, May-01, Volume: 20, Issue:9 | Structure-based rational design, synthesis and antifungal activity of oxime-containing azole derivatives. |
| AID567438 | Antifungal activity against Trichosporon inkin after 48 hrs by Etest | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | In vitro antifungal activities of isavuconazole and comparators against rare yeast pathogens. |
| AID546078 | Antifungal activity against Candida kefyr isolated from candidemia patient by AFST-EUCAST microdilution method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | A 10-year survey of antifungal susceptibility of candidemia isolates from intensive care unit patients in Greece. |
| AID1435655 | Antifungal activity against Candida albicans ATCC 44859 after 24 hrs by broth microdilution method | 2017 | European journal of medicinal chemistry, Jan-27, Volume: 126 | S-substituted 3,5-dinitrophenyl 1,3,4-oxadiazole-2-thiols and tetrazole-5-thiols as highly efficient antitubercular agents. |
| AID1888427 | Antifungal activity against azole-resistant Candida albicans 0304103 infected in ICR mouse assessed as reduction in fungal burden in kidney by measuring fungal colonization at 10 mg/kg, ip administered once daily for 5 days by Periodic acid-Schiff stainin | 2022 | European journal of medicinal chemistry, Jan-05, Volume: 227 | Heat shock protein 90 (Hsp90)/Histone deacetylase (HDAC) dual inhibitors for the treatment of azoles-resistant Candida albicans. |
| AID516271 | Antimicrobial activity against Cryptococcus gattii serotype B isolate NIH1123 assessed as concentration required for heteroresistance | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Heteroresistance of Cryptococcus gattii to fluconazole. |
| AID1370737 | Antifungal activity against Candida parapsilosis ATCC 22019 after 24 hrs by serial dilution method | 2018 | Bioorganic & medicinal chemistry letters, 02-01, Volume: 28, Issue:3 | Design, synthesis, and structure-activity relationship studies of novel tetrazole antifungal agents with potent activity, broad antifungal spectrum and high selectivity. |
| AID1493828 | Antifungal activity against Candida parapsilosis 22019 after 24 hrs by spectrophotometric analysis | 2018 | European journal of medicinal chemistry, Jan-01, Volume: 143 | Discovery of simplified sampangine derivatives as novel fungal biofilm inhibitors. |
| AID457999 | Antifungal activity against Trichophyton mentagrophytes 445 after 72 hrs by microdilution method | 2010 | Bioorganic & medicinal chemistry, Mar-01, Volume: 18, Issue:5 | Antifungal 3,5-disubstituted furanones: From 5-acyloxymethyl to 5-alkylidene derivatives. |
| AID386934 | Antifungal activity against Candida albicans ATCC 6019 after 48 hrs by broth microdilution technique | 2008 | European journal of medicinal chemistry, Oct, Volume: 43, Issue:10 | Carbodithioic acid esters of fluoxetine, a novel class of dual-function spermicides. |
| AID532549 | Antifungal activity against wild-type Saccharomyces cerevisiae BY4741 assessed as accumulation of ergosterol at 16 ug/ml (Rvb = 57+/- 1.00 %) | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | Differential azole antifungal efficacies contrasted using a Saccharomyces cerevisiae strain humanized for sterol 14 alpha-demethylase at the homologous locus. |
| AID386828 | Antimicrobial activity against Candida albicans NCIM 3100 after 16 to 18 hrs by serial dilution method | 2008 | European journal of medicinal chemistry, Aug, Volume: 43, Issue:8 | Convenient access to 1,3,4-trisubstituted pyrazoles carrying 5-nitrothiophene moiety via 1,3-dipolar cycloaddition of sydnones with acetylenic ketones and their antimicrobial evaluation. |
| AID762713 | Antimicrobial activity against Aspergillus flavus MTCC 873 at 50 ug/ml after 24 hrs by agar disc diffusion method | 2013 | Bioorganic & medicinal chemistry letters, Aug-15, Volume: 23, Issue:16 | Novel pyrazoline amidoxime and their 1,2,4-oxadiazole analogues: synthesis and pharmacological screening. |
| AID459756 | Antifungal activity against Aspergillus fumigatus by serial dilution method | 2010 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 20, Issue:3 | Synthesis and antifungal activities in vitro of novel pyrazino [2,1-a] isoquinolin derivatives. |
| AID519048 | Antifungal activity against Candida parapsilosis after 48 hrs by broth microdilution | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | Antimicrobial activity of omiganan pentahydrochloride against contemporary fungal pathogens responsible for catheter-associated infections. |
| AID405050 | Antifungal activity against Sporothrix schenckii P26187 isolate from cutaneous-lymphatic sporotrichosis patient after 72 hrs by ATB Fungus 2 method | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | In vitro susceptibility of Sporothrix schenckii to six antifungal agents determined using three different methods. |
| AID1491256 | Inhibition of CYP51 in Candida albicans ATCC SC5314 assessed as obtusifoliol content at 0.03125 ug/ml by GS-MS analysis relative to total sterols (Rvb = 0.6%) | 2017 | European journal of medicinal chemistry, Sep-08, Volume: 137 | Design, synthesis and evaluation of aromatic heterocyclic derivatives as potent antifungal agents. |
| AID352614 | Antifungal activity against Candida parapsilosis ATCC 22019 after 48 hrs by micro broth dilution method | 2009 | European journal of medicinal chemistry, Mar, Volume: 44, Issue:3 | 2,3-Disubstituted-1,4-naphthoquinones, 12H-benzo[b]phenothiazine-6,11-diones and related compounds: synthesis and biological evaluation as potential antiproliferative and antifungal agents. |
| AID489934 | Antifungal activity against Candida glabrata IFO 0622 after 24 hrs by microdilution method | 2010 | Bioorganic & medicinal chemistry letters, Jul-01, Volume: 20, Issue:13 | Novel pyridobenzimidazole derivatives exhibiting antifungal activity by the inhibition of beta-1,6-glucan synthesis. |
| AID1392807 | Antifungal activity against Candida albicans ATCC SC5314 after 24 hrs by serial dilution method | 2018 | Bioorganic & medicinal chemistry, 07-23, Volume: 26, Issue:12 | Design, synthesis and evaluation of benzoheterocycle analogues as potent antifungal agents targeting CYP51. |
| AID495356 | Antimicrobial activity against fluconazole susceptible Candida albicans 5054 expressing low levels of ERG11 and UPC2 mRNA by microdilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | An A643T mutation in the transcription factor Upc2p causes constitutive ERG11 upregulation and increased fluconazole resistance in Candida albicans. |
| AID369388 | Antimicrobial activity against Candida africana isolate | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | In vitro susceptibility to posaconazole of 1,903 yeast isolates recovered in France from 2003 to 2006 and tested by the method of the European committee on antimicrobial susceptibility testing. |
| AID42884 | Inhibition of Candida parapsilosis ATCC 22019 growth for 24 hours in vitro. | 2001 | Journal of medicinal chemistry, Aug-16, Volume: 44, Issue:17 | 3-Phenyl-5-acyloxymethyl-2H,5H-furan-2-ones: synthesis and biological activity of a novel group of potential antifungal drugs. |
| AID608754 | Antifungal activity against Aspergillus niger at 1000 ug/ml after 72 hrs by agar diffusion method | 2011 | European journal of medicinal chemistry, Aug, Volume: 46, Issue:8 | Synthesis, characterization and antimicrobial studies of some new pyrazole incorporated imidazole derivatives. |
| AID545714 | Antifungal activity against Cryptococcus neoformans after 72 hrs by serial dilution method | 2010 | European journal of medicinal chemistry, Dec, Volume: 45, Issue:12 | Novel conformationally restricted triazole derivatives with potent antifungal activity. |
| AID1157175 | Antifungal activity against Trichophyton mentagrophytes PMC 6503 after 72 hrs by CLSI broth microdilution method | 2014 | European journal of medicinal chemistry, Aug-18, Volume: 83 | Synthesis, biological evaluation and structure-activity correlation study of a series of imidazol-based compounds as Candida albicans inhibitors. |
| AID1196800 | Selectivity index, ratio of IC50 for rat L6 cells to IC50 for amastigote stage of Trypanosoma cruzi Tulahuen C4 infected in rat L6 cells | 2015 | Journal of medicinal chemistry, Feb-12, Volume: 58, Issue:3 | Novel 3-nitrotriazole-based amides and carbinols as bifunctional antichagasic agents. |
| AID1918367 | Antifungal activity against Candida albicans infected in mouse assessed as reduction in fungal proliferation in the infection region at 20 mg/kg, ip administered on days 2,4,6,8,10,12 and measured on day 14 by GMS staining based analysis | 2022 | Journal of medicinal chemistry, 11-10, Volume: 65, Issue:21 | Novel Aryl Alkamidazole Derivatives as Multifunctional Antifungal Inhibitors: Design, Synthesis, and Biological Evaluation. |
| AID407017 | Antimicrobial activity against Cdr1, Cdr2 and Mdr1 deficient Candida albicans DSY1050 intact biofilms after 48 hrs by XTT assay | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | Role for cell density in antifungal drug resistance in Candida albicans biofilms. |
| AID1487478 | Antifungal activity against Candida albicans after 24 hrs by well diffusion method | 2017 | Bioorganic & medicinal chemistry letters, 08-15, Volume: 27, Issue:16 | Synthesis, antioxidant, antifungal, molecular docking and ADMET studies of some thiazolyl hydrazones. |
| AID436740 | Antifungal activity against Candida albicans after 24 hrs by serial dilution method | 2009 | European journal of medicinal chemistry, Oct, Volume: 44, Issue:10 | New azoles with potent antifungal activity: design, synthesis and molecular docking. |
| AID1067043 | Antifungal activity against Trichophyton rubrum by micro-broth dilution method | 2014 | European journal of medicinal chemistry, Mar-03, Volume: 74 | Synthesis, antifungal activities and molecular docking studies of novel 2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propyl dithiocarbamates. |
| AID293381 | Antifungal activity against Candida tropicalis by micro-broth dilution method | 2007 | European journal of medicinal chemistry, Aug, Volume: 42, Issue:8 | Synthesis and evaluation of novel 1-(1H-1,2,4-triazol-1-yl)-2-(2,4-difluorophenyl)-3-[(4-substitutedphenyl)-piperazin-1-yl]-propan-2-ols as antifungal agents. |
| AID1287100 | Antimicrobial activity against Bacillus subtilis assessed as inhibition of bacterial growth after 16 hrs by broth dilution method | 2016 | Journal of medicinal chemistry, Mar-10, Volume: 59, Issue:5 | A Designed Tryptophan- and Lysine/Arginine-Rich Antimicrobial Peptide with Therapeutic Potential for Clinical Antibiotic-Resistant Candida albicans Vaginitis. |
| AID1419540 | Selectivity index, ratio of EC50 for toxicity in human BEAS2B cells to MIC50 for antifungal activity against Candida albicans ATCC 64124 | 2017 | European journal of medicinal chemistry, Jun-16, Volume: 133 | Novel alkylated azoles as potent antifungals. |
| AID1487217 | Inhibition of CYP51 in Cryptococcus neoformans assessed as inhibition of microbe growth incubated for 48 hrs by CLSI M27-A3 guideline based method | 2017 | Bioorganic & medicinal chemistry letters, 08-01, Volume: 27, Issue:15 | Design and optimization of highly-selective, broad spectrum fungal CYP51 inhibitors. |
| AID1550465 | Antifungal activity against Saccharomyces cerevisiae ATCC 9763 diameter of zone inhibition at 0.025 mg incubated for 24 hrs by disc diffusion method | 2019 | European journal of medicinal chemistry, Jun-01, Volume: 171 | Antimicrobial and KPC/AmpC inhibitory activity of functionalized benzosiloxaboroles. |
| AID1888268 | Induction of apoptosis in Candida albicans ATCC SC5314 cells assessed as live cells at 8 ug/ml incubated for 72 hrs by Annexin V-FITC/PI staining based flow cytometry method (Rvb = 95.56%) | |||
| AID1401696 | Antifungal against Saccharomyces cerevisiae after 24 hrs by two fold serial dilution method | 2018 | European journal of medicinal chemistry, Jan-01, Volume: 143 | Novel aminopyrimidinyl benzimidazoles as potentially antimicrobial agents: Design, synthesis and biological evaluation. |
| AID564268 | Effect on sterol composition in Candida albicans isolate 108 harboring erg11 and erg5 double mutant eburicol level after 2 hrs by gas chromatography | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | A clinical isolate of Candida albicans with mutations in ERG11 (encoding sterol 14alpha-demethylase) and ERG5 (encoding C22 desaturase) is cross resistant to azoles and amphotericin B. |
| AID1239968 | Antifungal activity against Aspergillus flavus ATCC 204304 after 24 hrs by microbroth dilution method | 2015 | Bioorganic & medicinal chemistry letters, Sep-01, Volume: 25, Issue:17 | Design and biological evaluation of novel quinolone-based metronidazole derivatives as potent Cu(2+) mediated DNA-targeting antibacterial agents. |
| AID279118 | Antimicrobial activity against Candida lusitaniae at 48 hrs | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Association of fluconazole area under the concentration-time curve/MIC and dose/MIC ratios with mortality in nonneutropenic patients with candidemia. |
| AID47867 | Evaluation of In vitro antifungal activity against Candida parapsilosis C292 by broth macro dilution method | 1995 | Journal of medicinal chemistry, Sep-29, Volume: 38, Issue:20 | Synthesis and antifungal activity of new azole derivatives containing an N-acylmorpholine ring. |
| AID48567 | Minimum concentration required to inhibit the growth of Candida albicans ATCC 24433 was determined | 2002 | Bioorganic & medicinal chemistry letters, Oct-07, Volume: 12, Issue:19 | Synthesis and evaluation of novel pyrrolidinyl sordaricin derivatives as antifungal agents. |
| AID1864917 | Toxicity in mouse infected with Candida albicans assessed as spleen injury at 10 ug per 20 g, ip administered on day 2, 4, 6, 8, 10 and 12 and measured on day 14 by H and E staining based assay | |||
| AID567447 | Antifungal activity against Trichosporon sp. after 3 days by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | In vitro antifungal activities of isavuconazole and comparators against rare yeast pathogens. |
| AID1287608 | Antifungal activity against Candida albicans ATCC 90028 after 18 to 24 hrs by micro-dilution method | 2016 | European journal of medicinal chemistry, May-04, Volume: 113 | Synthesis of newer 1,2,3-triazole linked chalcone and flavone hybrid compounds and evaluation of their antimicrobial and cytotoxic activities. |
| AID351033 | Antimicrobial activity against Candida albicans ATCC 10231 after 72 hrs by broth microdilution method | 2009 | European journal of medicinal chemistry, Mar, Volume: 44, Issue:3 | 2-Acylhydrazino-5-arylpyrrole derivatives: synthesis and antifungal activity evaluation. |
| AID405113 | Antimicrobial activity against Apophysomyces elegans assessed as percent of susceptible isolates after 24 hrs | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | In vitro susceptibilities of 217 clinical isolates of zygomycetes to conventional and new antifungal agents. |
| AID567333 | Antifungal activity against Saccharomyces cerevisiae after 5 days by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | In vitro antifungal activities of isavuconazole and comparators against rare yeast pathogens. |
| AID274916 | Antifungal activity against Candida albicans ATCC 90028 | 2006 | Journal of medicinal chemistry, Dec-28, Volume: 49, Issue:26 | Synthesis, antifungal activity, and structure-activity relationships of coruscanone A analogues. |
| AID584406 | Antifungal activity against 25 days cultured Candida glabrata isolated from invasive fungal infected subject blood receiving antifungal therapy for 25 days after 3 days of prophylaxis by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Impact of antifungal prophylaxis on colonization and azole susceptibility of Candida species. |
| AID1472814 | Antifungal activity against Candida albicans ATCC 64124 after 48 hrs by broth dilution method | 2018 | Journal of medicinal chemistry, 01-11, Volume: 61, Issue:1 | Alkylated Piperazines and Piperazine-Azole Hybrids as Antifungal Agents. |
| AID1918346 | Increase in intracellular ROS level in Candida albicans assessed as fold increase in fluorescence intensity measured after 12 hrs by fluorescence microscopic analysis relative to control | 2022 | Journal of medicinal chemistry, 11-10, Volume: 65, Issue:21 | Novel Aryl Alkamidazole Derivatives as Multifunctional Antifungal Inhibitors: Design, Synthesis, and Biological Evaluation. |
| AID655724 | Antifungal activity against Curvularia lunata MTCC 581 after 48 hrs by poison food method | 2012 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 22, Issue:8 | Design, synthesis, synergistic antimicrobial activity and cytotoxicity of 4-aryl substituted 3,4-dihydropyrimidinones of curcumin. |
| AID1864879 | Antifungal activity against Candida krusei ATCC 6258 assessed as fungal growth inhibition measured after 72 hrs by double dilution method | |||
| AID1651347 | Antifungal activity against Microsporum gypseum CMCC by NCCLS protocol based broth microdilution assay | 2020 | Bioorganic & medicinal chemistry letters, 02-15, Volume: 30, Issue:4 | Design, synthesis, and structure-activity relationship studies of novel triazole agents with strong antifungal activity against Aspergillus fumigatus. |
| AID214293 | Inhibition of Trichophyton mentagrophytes 445 growth for 72 hours in vitro. | 2001 | Journal of medicinal chemistry, Aug-16, Volume: 44, Issue:17 | 3-Phenyl-5-acyloxymethyl-2H,5H-furan-2-ones: synthesis and biological activity of a novel group of potential antifungal drugs. |
| AID1506722 | Antibacterial activity against Bacillus subtilis MTCC 121 by agar dilution method | 2017 | MedChemComm, Mar-01, Volume: 8, Issue:3 | Design, synthesis, molecular-docking and antimycobacterial evaluation of some novel 1,2,3-triazolyl xanthenones. |
| AID1890287 | Cytotoxicity against mouse NIH/3T3 cells assessed as reduction in cell viability at 25 ug/ml incubated for 48 hrs by MTT assay (Rvb = 93.8 +/- 4.9 %) | 2022 | Bioorganic & medicinal chemistry letters, 05-01, Volume: 63 | Novel 2-aryl-4-aryloxyquinoline-based fungistatics for Mucor circinelloides. Biological evaluation of activity, QSAR and docking study. |
| AID598295 | Antimicrobial activity against Candida glabrata isolate 49 after 48 hrs by microdilution broth method | 2011 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 21, Issue:11 | Synthesis and in vitro antimicrobial activities of new (cyano-NNO-azoxy)pyrazole derivatives. |
| AID50154 | Evaluation of In vitro antifungal activity against Candida krusei C64 by broth macro dilution method | 1995 | Journal of medicinal chemistry, Sep-29, Volume: 38, Issue:20 | Synthesis and antifungal activity of new azole derivatives containing an N-acylmorpholine ring. |
| AID1157155 | Antifungal activity against Candida krusei DSM 6128 after 48 hrs by CLSI broth microdilution method | 2014 | European journal of medicinal chemistry, Aug-18, Volume: 83 | Synthesis, biological evaluation and structure-activity correlation study of a series of imidazol-based compounds as Candida albicans inhibitors. |
| AID1885957 | Antifungal activity against Cryptococcus gattii WM179 assessed as fungal growth inhibition incubated for 72 hrs by broth microdilution method | |||
| AID1890267 | Antifungal activity against Mucor circinelloides R7B wild type strain assessed as reduction in spore germination at 50 ug/ml relative to control | 2022 | Bioorganic & medicinal chemistry letters, 05-01, Volume: 63 | Novel 2-aryl-4-aryloxyquinoline-based fungistatics for Mucor circinelloides. Biological evaluation of activity, QSAR and docking study. |
| AID1904358 | Antifungal activity against Candida tropicalis CGMCC 2.3739 assessed as fungal growth inhibition by CLSI based serial microbroth dilution method | 2022 | European journal of medicinal chemistry, Apr-05, Volume: 233 | Design, synthesis, and evaluation of novel 3-thiophene derivatives as potent fungistatic and fungicidal reagents based on a conformational restriction strategy. |
| AID424891 | Antimicrobial activity against azole-resistant Candida albicans isolate CA10 assessed as growth at 1 ug/ml cotreated with 0.016 ug/ml calcineurin signaling inhibitor tacrolimus after 48 hrs by microdilution checkerboard technique relative to control | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | In vitro interactions between tacrolimus and azoles against Candida albicans determined by different methods. |
| AID747354 | Antibacterial activity against Micrococcus luteus ATCC 4698 by NCCLS method | 2013 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 23, Issue:11 | Synthesis and biological evaluation of a class of quinolone triazoles as potential antimicrobial agents and their interactions with calf thymus DNA. |
| AID274918 | Antifungal activity against fluconazole-resistant Candida albicans | 2006 | Journal of medicinal chemistry, Dec-28, Volume: 49, Issue:26 | Synthesis, antifungal activity, and structure-activity relationships of coruscanone A analogues. |
| AID458000 | Antifungal activity against Trichophyton mentagrophytes 445 after 120 hrs by microdilution method | 2010 | Bioorganic & medicinal chemistry, Mar-01, Volume: 18, Issue:5 | Antifungal 3,5-disubstituted furanones: From 5-acyloxymethyl to 5-alkylidene derivatives. |
| AID8002 | Observed volume of distribution | 2004 | Journal of medicinal chemistry, Feb-26, Volume: 47, Issue:5 | Prediction of human volume of distribution values for neutral and basic drugs. 2. Extended data set and leave-class-out statistics. |
| AID285858 | Antimicrobial susceptibility of Pichia anomala from nosocomial fungemia patient assessed as percent susceptible isolates at 1 ug/ml by CLSI method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Antifungal drug susceptibility profile of Pichia anomala isolates from patients presenting with nosocomial fungemia. |
| AID405011 | Antifungal activity against Sporothrix schenckii P0019 isolate from cutaneous-lymphatic sporotrichosis patient after 72 hrs by ATB Fungus 2 method | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | In vitro susceptibility of Sporothrix schenckii to six antifungal agents determined using three different methods. |
| AID47583 | Evaluation of In vitro antifungal activity against Candida albicans 76 by broth macro dilution method | 1995 | Journal of medicinal chemistry, Sep-29, Volume: 38, Issue:20 | Synthesis and antifungal activity of new azole derivatives containing an N-acylmorpholine ring. |
| AID519053 | Antifungal activity against Paecilomyces variotii after 48 hrs by broth microdilution | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | Antimicrobial activity of omiganan pentahydrochloride against contemporary fungal pathogens responsible for catheter-associated infections. |
| AID531238 | Antifungal activity against Candida krusei after 48 hrs by CLSI method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | In vitro susceptibilities of invasive isolates of Candida species: rapid increase in rates of fluconazole susceptible-dose dependent Candida glabrata isolates. |
| AID1859329 | Antimicrobial activity against Candida glabrata ATCC 1182 | 2022 | Journal of medicinal chemistry, 02-24, Volume: 65, Issue:4 | Application of the All-Hydrocarbon Stapling Technique in the Design of Membrane-Active Peptides. |
| AID521537 | Antifungal activity against Aspergillus fumigatus clinical isolates after 48 hrs by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | In vitro and in vivo antifungal activities of T-2307, a novel arylamidine. |
| AID555593 | Antimicrobial activity against Trichosporon ovoides by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Activity profile in vitro of micafungin against Spanish clinical isolates of common and emerging species of yeasts and molds. |
| AID1419499 | Antifungal activity against ITC and FLC-resistant Candida albicans ATCC MYA-1003 incubated for 48 hrs by modified CLSI M27-A3 protocol based method | 2017 | European journal of medicinal chemistry, Jun-16, Volume: 133 | Novel alkylated azoles as potent antifungals. |
| AID521535 | Antifungal activity against Candida tropicalis clinical isolates after 48 hrs by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | In vitro and in vivo antifungal activities of T-2307, a novel arylamidine. |
| AID287823 | Antifungal activity against Candida krusei E28 after 24 hrs | 2007 | Bioorganic & medicinal chemistry, Apr-15, Volume: 15, Issue:8 | Hybrid molecules of estrone: new compounds with potential antibacterial, antifungal, and antiproliferative activities. |
| AID750175 | Antifungal activity against Candida tropicalis after 24 hrs by NCCLS method | 2013 | European journal of medicinal chemistry, Jun, Volume: 64 | Discovery of highly potent triazole antifungal derivatives by heterocycle-benzene bioisosteric replacement. |
| AID655710 | Antifungal activity against Aspergillus flavus MTCC 1021 at 160 uM/ml after 48 hrs by paper disc diffusion method | 2012 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 22, Issue:8 | Design, synthesis, synergistic antimicrobial activity and cytotoxicity of 4-aryl substituted 3,4-dihydropyrimidinones of curcumin. |
| AID1918370 | Antifungal activity against Candida albicans infected in mouse assessed as reduction in necrotic cell fragments in intercellular spaces of the infection region at 20 mg/kg, ip administered on days 2,4,6,8,10,12 and measured on day 14 by GMS staining based | 2022 | Journal of medicinal chemistry, 11-10, Volume: 65, Issue:21 | Novel Aryl Alkamidazole Derivatives as Multifunctional Antifungal Inhibitors: Design, Synthesis, and Biological Evaluation. |
| AID245494 | Minimum inhibitory concentration against Candida parapsilosis ATCC 22019 evaluated by in vitro agar diffusion and micro-broth dilution assay | 2005 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 15, Issue:15 | Synthesis of some diguanidino 1-methyl-2,5-diaryl-1H-pyrroles as antifungal agents. |
| AID1369449 | Antifungal activity against fluconazole-resistant Candida albicans 56452 after 48 hrs by broth microdilution method | 2018 | Journal of medicinal chemistry, 05-10, Volume: 61, Issue:9 | Combating Drug-Resistant Fungi with Novel Imperfectly Amphipathic Palindromic Peptides. |
| AID1911620 | Antifungal activity against Candida albicans CA17 assessed as fungal growth inhibition by broth microdilution assay | 2022 | Journal of medicinal chemistry, 06-09, Volume: 65, Issue:11 | Development of Lipo-γ-AA Peptides as Potent Antifungal Agents. |
| AID1287613 | Antifungal activity against Dermatophyte clinical isolate after 18 to 24 hrs by micro-dilution method | 2016 | European journal of medicinal chemistry, May-04, Volume: 113 | Synthesis of newer 1,2,3-triazole linked chalcone and flavone hybrid compounds and evaluation of their antimicrobial and cytotoxic activities. |
| AID429398 | Antifungal activity against Candida albicans MTCC 227 after 24 to 72 hrs by broth dilution method | 2009 | European journal of medicinal chemistry, Aug, Volume: 44, Issue:8 | Mechanism of unusual formation of 3-(5-phenyl-3H-[1,2,4]dithiazol-3-yl)chromen-4-ones and 4-oxo-4H-chromene-3-carbothioic acid N-phenylamides and their antimicrobial evaluation. |
| AID1487214 | Inhibition of CYP51 in Aspergillus fumigatus assessed as inhibition of microbe growth incubated for 48 to 168 hrs by CLSI M27-A3 guideline based method | 2017 | Bioorganic & medicinal chemistry letters, 08-01, Volume: 27, Issue:15 | Design and optimization of highly-selective, broad spectrum fungal CYP51 inhibitors. |
| AID530981 | Antifungal activity against Candida albicans ATCC 200955 after 48 hrs by CLSI method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Potent in vitro antifungal activities of naturally occurring acetylenic acids. |
| AID531239 | Antifungal activity against Candida lusitaniae after 48 hrs by CLSI method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | In vitro susceptibilities of invasive isolates of Candida species: rapid increase in rates of fluconazole susceptible-dose dependent Candida glabrata isolates. |
| AID598231 | Antimicrobial activity against Candida tropicalis isolate 15 after 48 hrs by microdilution broth method | 2011 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 21, Issue:11 | Synthesis and in vitro antimicrobial activities of new (cyano-NNO-azoxy)pyrazole derivatives. |
| AID329035 | Antifungal activity against Candida albicans ATCC 90028 at 25 ug/disc after 24 hrs by disc diffusion assay | 2008 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 18, Issue:8 | Synthesis and antimicrobial properties of monensin A esters. |
| AID1885995 | Antifungal activity against Cryptococcus neoformans clinical isolate HN20 assessed as fungal growth inhibition incubated for 72 hrs in presence of P163-0892 by broth microdilution method | |||
| AID670397 | Antifungal activity against Candida parapsilosis MTCC 1744 by well diffusion method | 2012 | Bioorganic & medicinal chemistry letters, Jul-15, Volume: 22, Issue:14 | Synthesis, biological evaluation of 5-carbomethoxymethyl-7-hydroxy-2-pentylchromone, 5-carboethoxymethyl-4',7-dihydroxyflavone and their analogues. |
| AID525411 | Fungistatic activity against Candida parapsilosis ATCC 22019 assessed as 99.9% reduction of int initial fungal load at 8 times MIC after 48 hrs using colony count method by time-kill method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Posaconazole against Candida glabrata isolates with various susceptibilities to fluconazole. |
| AID670395 | Antifungal activity against Candida albicans MTCC 7315 by well diffusion method | 2012 | Bioorganic & medicinal chemistry letters, Jul-15, Volume: 22, Issue:14 | Synthesis, biological evaluation of 5-carbomethoxymethyl-7-hydroxy-2-pentylchromone, 5-carboethoxymethyl-4',7-dihydroxyflavone and their analogues. |
| AID289663 | Antimicrobial activity against Bacillus anthracis at 400 ug/ml after 48 hrs by disc-diffusion assay | 2007 | Bioorganic & medicinal chemistry letters, Jan-15, Volume: 17, Issue:2 | N/C-4 substituted azetidin-2-ones: synthesis and preliminary evaluation as new class of antimicrobial agents. |
| AID1498766 | Antifungal activity against Beer yeast after 24 hrs by two fold serial dilution based spectrophotometric analysis | 2018 | Bioorganic & medicinal chemistry letters, 08-01, Volume: 28, Issue:14 | Azoalkyl ether imidazo[2,1-b]benzothiazoles as potentially antimicrobial agents with novel structural skeleton. |
| AID1905252 | Synergistic antifungal activity against fluconazole-resistant Candida albicans 901 assessed as inhibition of fungal growth in presence of fluconazole by checker board microdilution assay | 2022 | Journal of medicinal chemistry, 04-14, Volume: 65, Issue:7 | Species-Selective Targeting of Fungal Hsp90: Design, Synthesis, and Evaluation of Novel 4,5-Diarylisoxazole Derivatives for the Combination Treatment of Azole-Resistant Candidiasis. |
| AID490328 | Antimicrobial activity against Bacillus subtilis ATCC 6633 at 4 ug/disk by disk diffusion method | 2010 | European journal of medicinal chemistry, Jul, Volume: 45, Issue:7 | Synthesis and biological evaluation of some thio containing pyrrolo [2,3-d]pyrimidine derivatives for their anti-inflammatory and anti-microbial activities. |
| AID1491264 | Inhibition of CYP51 in Candida albicans ATCC SC5314 assessed as lanosterol content at 8 ug/ml by GS-MS analysis relative to total sterols | 2017 | European journal of medicinal chemistry, Sep-08, Volume: 137 | Design, synthesis and evaluation of aromatic heterocyclic derivatives as potent antifungal agents. |
| AID745260 | Antifungal activity against Candida krusei ATCC 6258 after 18 to 24 hrs by micro-dilution method | 2013 | European journal of medicinal chemistry, May, Volume: 63 | Design, synthesis and antimicrobial activity of novel benzothiazole analogs. |
| AID365072 | Antifungal activity against Aspergillus fumigatus ATCC 46645 after 3 days by broth macrodilution method | 2008 | Bioorganic & medicinal chemistry, Sep-01, Volume: 16, Issue:17 | Antifungal activity of synthetic di(hetero)arylamines based on the benzo[b]thiophene moiety. |
| AID1565879 | Antifungal activity against Aspergillus flavus ATCC 16870 assessed as growth inhibition measured after 24 hrs by two-fold broth dilution method | 2019 | European journal of medicinal chemistry, Nov-15, Volume: 182 | Design, synthesis and biological evaluation of novel diazaspiro[4.5]decan-1-one derivatives as potential chitin synthase inhibitors and antifungal agents. |
| AID294851 | Antifungal activity against Cryptococcus neoformans ATCC BLS108 after 72 hrs by micro-broth dilution method | 2007 | European journal of medicinal chemistry, Sep, Volume: 42, Issue:9 | Synthesis of novel triazole derivatives as inhibitors of cytochrome P450 14alpha-demethylase (CYP51). |
| AID1595078 | Antifungal activity against Saccharomyces cerevisiae | 2019 | European journal of medicinal chemistry, May-15, Volume: 170 | Tetrazole hybrids and their antifungal activities. |
| AID245571 | In vitro concentration required to inhibit 80% growth of Saccharomyces cerevisiae strain YEM171 (CDR2 over-expressed) after 48 h | 2004 | Bioorganic & medicinal chemistry letters, Oct-18, Volume: 14, Issue:20 | Quinazolinone fungal efflux pump inhibitors. Part 2: In vitro structure-activity relationships of (N-methyl-piperazinyl)-containing derivatives. |
| AID670551 | Antifungal activity against Candida aaseri MTCC 1962 after 24 hrs by well diffusion method | 2012 | Bioorganic & medicinal chemistry letters, Jul-15, Volume: 22, Issue:14 | Total synthesis and antifungal activity of (2S,3R)-2-aminododecan-3-ol. |
| AID719032 | Antifungal activity against Candida albicans ATCC 44859 assessed as growth inhibition after 48 hrs by CLSI M27-A2 broth microdilution method | 2012 | Bioorganic & medicinal chemistry, Dec-15, Volume: 20, Issue:24 | Anti-infective and herbicidal activity of N-substituted 2-aminobenzothiazoles. |
| AID1419500 | Antifungal activity against Candida glabrata ATCC 2001 incubated for 48 hrs by modified CLSI M27-A3 protocol based method | 2017 | European journal of medicinal chemistry, Jun-16, Volume: 133 | Novel alkylated azoles as potent antifungals. |
| AID307400 | Antifungal activity against Aspergillus fumigatus ATCC 16424 by broth microdilution assay | 2007 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 17, Issue:12 | Discovery of novel indazole-linked triazoles as antifungal agents. |
| AID555008 | Antifungal activity against Candida holmii assessed as percent susceptible isolates at 25 ug/disc by CLSI M44-A disk diffusion method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | In vitro activities of fluconazole and voriconazole against clinical isolates of Candida spp. determined by disk diffusion testing in Turin, Italy. |
| AID1767306 | Antifungal activity against Candida albicans ATCC 90023 assessed as fungal growth inhibition by CLSI protocol based microbroth dilution method | 2021 | European journal of medicinal chemistry, Oct-05, Volume: 221 | Discovery of novel purinylthiazolylethanone derivatives as anti-Candida albicans agents through possible multifaceted mechanisms. |
| AID424651 | Antimicrobial activity against azole-resistant Candida albicans isolate CA10 assessed as growth at 0.5 ug/ml cotreated with 0.063 ug/ml calcineurin signaling inhibitor Tacrolimus after 48 hrs by microdilution checkboard technique relative to control | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | In vitro interactions between tacrolimus and azoles against Candida albicans determined by different methods. |
| AID1224553 | Antifungal activity against Trichosporon asahii 1188 after 24 hrs by broth microdilution method | 2014 | European journal of medicinal chemistry, Jul-23, Volume: 82 | 1-Substituted-5-[(3,5-dinitrobenzyl)sulfanyl]-1H-tetrazoles and their isosteric analogs: A new class of selective antitubercular agents active against drug-susceptible and multidrug-resistant mycobacteria. |
| AID1595044 | Antifungal activity against Cryptococcus neoformans LA314 assessed as reduction in fungal cell growth incubated for 48 hrs by broth microdilution method | 2019 | European journal of medicinal chemistry, May-15, Volume: 170 | Tetrazole hybrids and their antifungal activities. |
| AID623056 | Antifungal activity against Trichophyton mentagrophytes 445 after 72 hrs by microdilution method | 2011 | Bioorganic & medicinal chemistry letters, Oct-15, Volume: 21, Issue:20 | Synthesis and biological activity of desmethoxy analogues of coruscanone A. |
| AID1600161 | Antifungal activity against azole-susceptible Candida albicans ATCC 90028 assessed as reduction in fungal growth incubated for 48 hrs by broth microdilution method | 2019 | European journal of medicinal chemistry, Oct-01, Volume: 179 | Discovery of new azoles with potent activity against Candida spp. and Candida albicans biofilms through virtual screening. |
| AID519496 | Antifungal activity against Candida parapsilosis isolates after 48 hrs by CLSI M27-A2 procedure based assay | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | In vitro antifungal activities of isavuconazole (BAL4815), voriconazole, and fluconazole against 1,007 isolates of zygomycete, Candida, Aspergillus, Fusarium, and Scedosporium species. |
| AID1471215 | Antifungal activity against Sporothrix schenckii by spectrophotometric method | 2017 | Bioorganic & medicinal chemistry letters, 07-01, Volume: 27, Issue:13 | Diversity-oriented sustainable synthesis of antimicrobial spiropyrrolidine/thiapyrrolizidine oxindole derivatives: New ligands for a metallo-β-lactamase from Klebsiella pneumonia. |
| AID1543303 | Antimicrobial activity against Cryptococcus neoformans ATCC 90113 assessed as inhibition of microbial growth by CLSI based method | 2019 | Journal of natural products, 07-26, Volume: 82, Issue:7 | Anthraquinone-Based Specialized Metabolites from Rhizomes of |
| AID530921 | Antifungal activity against Candida albicans ATCC 200955 at 163.3 uM after 48 hrs by CLSI method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Potent in vitro antifungal activities of naturally occurring acetylenic acids. |
| AID584384 | Ratio of ERG11 gene expression in Candida glabrata isolated from patient 491 receiving antifungal drug to ERG11 gene expression in Candida glabrata isolated from patient 491 by RT-PCR analysis | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Impact of antifungal prophylaxis on colonization and azole susceptibility of Candida species. |
| AID1888270 | Induction of apoptosis in Candida albicans ATCC SC5314 cells assessed as necrotic cells at 8 ug/ml incubated for 72 hrs by Annexin V-FITC/PI staining based flow cytometry method (Rvb = 3.76%) | |||
| AID1061736 | Antimicrobial activity against Microsporum gypseum by broth microdilution method | 2014 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 24, Issue:1 | Synthesis and evaluation of novel azoles as potent antifungal agents. |
| AID220226 | In vitro for antifungal activity against 10 yeasts | 1998 | Journal of medicinal chemistry, May-21, Volume: 41, Issue:11 | New azole antifungals. 3. Synthesis and antifungal activity of 3-substituted-4(3H)-quinazolinones. |
| AID1254072 | Antibacterial activity against Escherichia coli CCARM 1356 after 24 hrs by two-fold serial dilution method | 2015 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 25, Issue:22 | Synthesis and biological evaluation of 1,3-diaryl pyrazole derivatives as potential antibacterial and anti-inflammatory agents. |
| AID567428 | Antifungal activity against Dipodascus capitatus after 4 days by Etest | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | In vitro antifungal activities of isavuconazole and comparators against rare yeast pathogens. |
| AID1154827 | Inhibition of biofilm formation of fluconazole-sensitive Candida albicans SC5314 at 64 ug/ml after 48 hrs by XTT assay relative to control | 2014 | ACS medicinal chemistry letters, May-08, Volume: 5, Issue:5 | Novel carboline derivatives as potent antifungal lead compounds: design, synthesis, and biological evaluation. |
| AID1624170 | Antifungal activity against Candida albicans NR-29448 after 24 hrs by microbroth dilution method | 2019 | Bioorganic & medicinal chemistry letters, 03-01, Volume: 29, Issue:5 | Benzimidazole tethered pyrrolo[3,4-b]quinoline with broad-spectrum activity against fungal pathogens. |
| AID1405038 | Antifungal activity against Aspergillus fumigatus after 24 hrs by two-fold broth microdilution assay | 2018 | European journal of medicinal chemistry, Jul-15, Volume: 155 | Novel carbazole-triazole conjugates as DNA-targeting membrane active potentiators against clinical isolated fungi. |
| AID1698474 | Antifungal activity against Candida albicans ATCC 10231 assessed as reduction in microbial growth after 5 days by microdilution method | 2020 | Journal of natural products, 10-23, Volume: 83, Issue:10 | Paecilosetin Derivatives as Potent Antimicrobial Agents from |
| AID365068 | Antifungal activity against Trichophyton mentagrophytes FF7 after 5 days by broth macrodilution method | 2008 | Bioorganic & medicinal chemistry, Sep-01, Volume: 16, Issue:17 | Antifungal activity of synthetic di(hetero)arylamines based on the benzo[b]thiophene moiety. |
| AID1418537 | Cytotoxicity against rat H9c2 cells by MTT assay | 2018 | Bioorganic & medicinal chemistry letters, 12-01, Volume: 28, Issue:22 | Design, synthesis, and biological evaluation of 4-chloro-2H-thiochromenes featuring nitrogen-containing side chains as potent antifungal agents. |
| AID1355705 | Antifungal activity against FLC resistant Candida albicans 0304103 after 48 hrs by checkerboard microdilution method | 2018 | Journal of medicinal chemistry, Jul-26, Volume: 61, Issue:14 | Discovery of Janus Kinase 2 (JAK2) and Histone Deacetylase (HDAC) Dual Inhibitors as a Novel Strategy for the Combinational Treatment of Leukemia and Invasive Fungal Infections. |
| AID419589 | Antimicrobial activity against Aspergillus niger after 7 days by tube dilution method | 2009 | European journal of medicinal chemistry, Jun, Volume: 44, Issue:6 | Synthesis, antimicrobial and antiviral evaluation of substituted imidazole derivatives. |
| AID712900 | Antifungal activity against Aspergillus flavus after 72 hrs by broth dilution method | 2012 | European journal of medicinal chemistry, Aug, Volume: 54 | Synthesis and evaluation of antimicrobial activity of 4H-pyrimido[2,1-b]benzothiazole, pyrazole and benzylidene derivatives of curcumin. |
| AID1557085 | Antifungal activity against Candida albicans ATCC 90028 assessed as reduction in fungal cell growth incubated for 48 hrs by MTT based broth double dilution method | 2019 | European journal of medicinal chemistry, Oct-01, Volume: 179 | Antifungal activity, mode of action variability, and subcellular distribution of coumarin-based antifungal azoles. |
| AID1719181 | Antifungal activity against fluconazole-resistant Candida albicans Gu5 assessed as reduction in microbial growth | 2021 | Bioorganic & medicinal chemistry letters, 03-01, Volume: 35 | A new 1-nitro-9-aminoacridine derivative targeting yeast topoisomerase II able to overcome fluconazole-resistance. |
| AID521972 | Antibacterial activity against azole-susceptible Candida albicans DSY294 containing CIp10 to restore URA3 function infected in BALB/c mouse assessed as weight change administered intraperitoneally 1 hr post bacterial challenge measured 3 days post infecti | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Genetic dissection of azole resistance mechanisms in Candida albicans and their validation in a mouse model of disseminated infection. |
| AID547564 | Antifungal activity against Candida tropicalis after 24 to 72 hrs by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | In vitro antifungal activities of bis(alkylpyridinium)alkane compounds against pathogenic yeasts and molds. |
| AID424902 | Antimicrobial activity against azole-resistant Candida albicans isolate CA10 assessed as growth at 1 ug/ml cotreated with 0.008 ug/ml calcineurin signaling inhibitor Tacrolimus after 48 hrs by microdilution checkboard technique relative to control | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | In vitro interactions between tacrolimus and azoles against Candida albicans determined by different methods. |
| AID574604 | Antifungal activity against Aspergillus fumigatus 231 after 24 hrs by broth microdilution method | 2011 | Bioorganic & medicinal chemistry, Feb-15, Volume: 19, Issue:4 | Synthesis and antimycobacterial properties of N-substituted 6-amino-5-cyanopyrazine-2-carboxamides. |
| AID1408110 | Antifungal activity against Aspergillus flavus 3375 after 48 hrs by two-fold serial dilution method | 2018 | European journal of medicinal chemistry, Sep-05, Volume: 157 | Design, synthesis, antimicrobial, antiquorum-sensing and antitumor evaluation of new series of pyrazolopyridine derivatives. |
| AID642929 | Antifungal activity against Trichophyton mentagrophytes ATCC 9533 | 2011 | ACS medicinal chemistry letters, May-12, Volume: 2, Issue:5 | Natural Product Based 6-Hydroxy-2,3,4,6-tetrahydropyrrolo[1,2-a]pyrimidinium Scaffold as A New Antifungal Template. |
| AID301288 | Antifungal activity against Candida krusei ATCC 6258 after 48 hrs by broth micro dilution technique | 2007 | Bioorganic & medicinal chemistry, Nov-01, Volume: 15, Issue:21 | Synthesis of disulfide esters of dialkylaminocarbothioic acid as potent, non-detergent spermicidal agents. |
| AID562988 | Antifungal activity against Candida albicans isolate 03-2718 infected BALB/c mouse vaginitis model assessed as reduction in fungal load in vagina at 20 mg/kg, administered through oral gavage twice daily for 5 days measured on day 6 post inoculation | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | Efficacy of albaconazole against Candida albicans in a vaginitis model. |
| AID609890 | Antifungal activity against Candida albicans Y0109 by micro-broth dilution method | 2011 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 21, Issue:15 | Synthesis, in vitro evaluation and molecular docking studies of new triazole derivatives as antifungal agents. |
| AID1235460 | Antifungal activity against clinical isolates of Candida albicans 2367 after 48 hrs by disc diffusion assay | 2015 | Bioorganic & medicinal chemistry, Aug-01, Volume: 23, Issue:15 | Imidazole clubbed 1,3,4-oxadiazole derivatives as potential antifungal agents. |
| AID519056 | Antifungal activity against Candida albicans assessed as susceptible isolates after 48 hrs by broth microdilution | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | Antimicrobial activity of omiganan pentahydrochloride against contemporary fungal pathogens responsible for catheter-associated infections. |
| AID1367152 | Antifungal activity against Candida tropicalis 156 after 48 hrs by microdilution broth method | 2017 | Bioorganic & medicinal chemistry letters, 12-01, Volume: 27, Issue:23 | Synthesis and biological evolution of hydrazones derived from 4-(trifluoromethyl)benzohydrazide. |
| AID1859330 | Antimicrobial activity against Candida glabrata 896 | 2022 | Journal of medicinal chemistry, 02-24, Volume: 65, Issue:4 | Application of the All-Hydrocarbon Stapling Technique in the Design of Membrane-Active Peptides. |
| AID582233 | Antifungal activity against Candida krusei isolated from neutropenic subjects with AML or MDS receiving posaconazole by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Impact of antifungal prophylaxis on colonization and azole susceptibility of Candida species. |
| AID293379 | Antifungal activity against Candida parapsilosis ATCC 22019 by micro-broth dilution method | 2007 | European journal of medicinal chemistry, Aug, Volume: 42, Issue:8 | Synthesis and evaluation of novel 1-(1H-1,2,4-triazol-1-yl)-2-(2,4-difluorophenyl)-3-[(4-substitutedphenyl)-piperazin-1-yl]-propan-2-ols as antifungal agents. |
| AID519679 | Antimicrobial activity against Saccharomyces cerevisiae containing disruption in APL2 gene by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Genomewide screening for genes associated with gliotoxin resistance and sensitivity in Saccharomyces cerevisiae. |
| AID584413 | Antifungal activity against 9 days cultured Candida tropicalis isolated from neutropenic subject with AML or MDS stool receiving antifungal therapy for 45 days after 24 days of prophylaxis by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Impact of antifungal prophylaxis on colonization and azole susceptibility of Candida species. |
| AID1419571 | Selectivity index, ratio of EC50 for toxicity in human A549 cells to MIC50 for antifungal activity against Aspergillus nidulans ATCC 38163 | 2017 | European journal of medicinal chemistry, Jun-16, Volume: 133 | Novel alkylated azoles as potent antifungals. |
| AID167736 | In vivo antifungal activity against systemic candidosis in rabbit kidney at a dose of 12.5 mg/kg, qd, po. | 1998 | Journal of medicinal chemistry, May-21, Volume: 41, Issue:11 | New azole antifungals. 3. Synthesis and antifungal activity of 3-substituted-4(3H)-quinazolinones. |
| AID1905289 | Anti biofilm activity in Candida albicans 904 assessed as downregulation of ALS3 at 32 ug/ml incubated for 24 hrs by RT-PCR analysis | 2022 | Journal of medicinal chemistry, 04-14, Volume: 65, Issue:7 | Species-Selective Targeting of Fungal Hsp90: Design, Synthesis, and Evaluation of Novel 4,5-Diarylisoxazole Derivatives for the Combination Treatment of Azole-Resistant Candidiasis. |
| AID1392818 | Inhibition of Cyp51 in Candida albicans ATCC SC5314 assessed as obtusifoliol content at 0.125 ug/ml after 16 hrs by GC-MS analysis (Rvb = 0.6%) | 2018 | Bioorganic & medicinal chemistry, 07-23, Volume: 26, Issue:12 | Design, synthesis and evaluation of benzoheterocycle analogues as potent antifungal agents targeting CYP51. |
| AID1634361 | Antifungal activity against Aspergillus fumigatus cgmcc 3.7795 assessed as inhibition of visible microbe growth by broth microdilution method | 2019 | Bioorganic & medicinal chemistry letters, 09-01, Volume: 29, Issue:17 | Design, synthesis and evaluation of biphenyl imidazole analogues as potent antifungal agents. |
| AID1738700 | Antifungal activity against Candida albicans CPCC400616 measured after 24 hrs by micro-broth dilution assay | 2020 | European journal of medicinal chemistry, Jul-15, Volume: 198 | Design, synthesis, and biological evaluation of novel miconazole analogues containing selenium as potent antifungal agents. |
| AID310269 | Antimicrobial activity against Saccharomyces cerevisiae AD by serial dilution microplate method | 2007 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 17, Issue:23 | Rational design of N-alkyl derivatives of 2-amino-2-deoxy-d-glucitol-6P as antifungal agents. |
| AID356366 | Antifungal activity against Candida albicans ATCC 90028 by sphingolipid reversal assay in presence of 2.5 ug/mL dihydrosphingosine | 2003 | Journal of natural products, Aug, Volume: 66, Issue:8 | Acetylenic acids inhibiting azole-resistant Candida albicans from Pentagonia gigantifolia. |
| AID1890299 | Antifungal activity against Mucor circinelloides R7B wild type strain assessed as few mycelia with several spores at 50 ug/ml by microscopic analysis | 2022 | Bioorganic & medicinal chemistry letters, 05-01, Volume: 63 | Novel 2-aryl-4-aryloxyquinoline-based fungistatics for Mucor circinelloides. Biological evaluation of activity, QSAR and docking study. |
| AID606219 | Antifungal activity against Microsporum gypseum after 7 days by micro-broth dilution method | 2011 | European journal of medicinal chemistry, Jul, Volume: 46, Issue:7 | Design, synthesis and antifungal activities of novel 1,2,4-triazole derivatives. |
| AID518680 | Antimicrobial activity against Cryptococcus gattii serotype C isolate H0058-1-818 assessed as heteroresistant isolates at 8 ug/ml | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Heteroresistance of Cryptococcus gattii to fluconazole. |
| AID1728460 | Antifungal activity against Candida tropicalis ATCC 1369 assessed as inhibition of microbial growth by NCCLS protocol based method | 2021 | European journal of medicinal chemistry, Jan-15, Volume: 210 | Novel naphthylamide derivatives as dual-target antifungal inhibitors: Design, synthesis and biological evaluation. |
| AID519052 | Antifungal activity against Fusarium sp. after 48 hrs by broth microdilution | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | Antimicrobial activity of omiganan pentahydrochloride against contemporary fungal pathogens responsible for catheter-associated infections. |
| AID644829 | Antifungal activity against Candida albicans ATCC 24433 after 48 hrs by M27-A3 CLSI method | 2012 | European journal of medicinal chemistry, Mar, Volume: 49 | Synthesis and antifungal activity of a new series of 2-(1H-imidazol-1-yl)-1-phenylethanol derivatives. |
| AID1302234 | Antifungal activity against azole-susceptible Candida albicans isolate DSY294 in immunocompetent Balb/c mouse candidiasis model assessed as reduction in CFU count in spleen at 8 mg/kg/day, ip regime measured on day 7 post infection | 2016 | Journal of medicinal chemistry, 04-28, Volume: 59, Issue:8 | Biological Characterization and in Vivo Assessment of the Activity of a New Synthetic Macrocyclic Antifungal Compound. |
| AID1698052 | Antifungal activity against Candida albicans assessed as inhibition of bacterial growth incubated for overnight by CLSI based method | 2020 | Bioorganic & medicinal chemistry letters, 11-15, Volume: 30, Issue:22 | Design and synthesis of new indanol-1,2,3-triazole derivatives as potent antitubercular and antimicrobial agents. |
| AID1809924 | Induction of drug resistance in Candida albicans ATCC SC5314 assessed as increase in FCZ IC50 at 8 times IC50 measured after 5 to 22 days | 2021 | Journal of medicinal chemistry, 11-11, Volume: 64, Issue:21 | Optimization and Evaluation of Novel Antifungal Agents for the Treatment of Fungal Infection. |
| AID1864895 | Antifungal activity against fluconazole -resistant Candida albicans 904 assessed as fungal growth inhibition measured after 72 hrs by double dilution method | |||
| AID572693 | Binding affinity to Mycobacterium smegmatis ATCC 700084 CYP51 in presence of 0.5 M NaCl at pH7.5 | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Identification, characterization, and azole-binding properties of Mycobacterium smegmatis CYP164A2, a homolog of ML2088, the sole cytochrome P450 gene of Mycobacterium leprae. |
| AID1551295 | Antibacterial activity against Pseudomonas aeruginosa 2742 assessed as reduction in bacterial cell growth incubated for 24 hrs by ELISA | 2019 | European journal of medicinal chemistry, Jun-15, Volume: 172 | Synthesis and biological evaluation of tryptophan-derived rhodanine derivatives as PTP1B inhibitors and anti-bacterial agents. |
| AID419590 | Antimicrobial activity against Candida albicans after 48 hrs by tube dilution method | 2009 | European journal of medicinal chemistry, Jun, Volume: 44, Issue:6 | Synthesis, antimicrobial and antiviral evaluation of substituted imidazole derivatives. |
| AID519677 | Antimicrobial activity against Saccharomyces cerevisiae containing disruption in OP11 gene by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Genomewide screening for genes associated with gliotoxin resistance and sensitivity in Saccharomyces cerevisiae. |
| AID546073 | Antifungal activity against Candida tropicalis isolated from candidemia patient by AFST-EUCAST microdilution method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | A 10-year survey of antifungal susceptibility of candidemia isolates from intensive care unit patients in Greece. |
| AID1079938 | Chronic liver disease either proven histopathologically, or through a chonic elevation of serum amino-transferase activity after 6 months. Value is number of references indexed. [column 'CHRON' in source] | |||
| AID1348787 | Antifungal activity against Candida albicans ATCC 66027 after 48 hrs by broth microdilution method | 2018 | European journal of medicinal chemistry, Jan-01, Volume: 143 | Substituted carbamothioic amine-1-carbothioic thioanhydrides as novel trichomonicidal fungicides: Design, synthesis, and biology. |
| AID595737 | Antimicrobial activity against Aspergillus flavus after 48 hrs by broth microdilution method | 2011 | European journal of medicinal chemistry, May, Volume: 46, Issue:5 | Design, synthesis and in vitro antimicrobial evaluation of novel Imidazo[1,2-a]pyridine and imidazo[2,1-b][1,3]benzothiazole motifs. |
| AID521505 | Antifungal activity against Malassezia furfur NBRC 0656 after 48 hrs by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | In vitro and in vivo antifungal activities of T-2307, a novel arylamidine. |
| AID1472825 | Antifungal activity against Aspergillus terreus ATCC MYA-3633 after 48 hrs by broth dilution method | 2018 | Journal of medicinal chemistry, 01-11, Volume: 61, Issue:1 | Alkylated Piperazines and Piperazine-Azole Hybrids as Antifungal Agents. |
| AID459757 | Antifungal activity against Trichophyton rubrum by serial dilution method | 2010 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 20, Issue:3 | Synthesis and antifungal activities in vitro of novel pyrazino [2,1-a] isoquinolin derivatives. |
| AID519467 | Antimicrobial activity against Cryptococcus neoformans var. grubii obtained from non-AIDS patient by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | In Vitro activity of the new azole isavuconazole (BAL4815) compared with six other antifungal agents against 162 Cryptococcus neoformans isolates from Cuba. |
| AID1759454 | Induction of morphological changes in Cryptococcus neoformans PFCC 93-589 assessed as disorganization of cytoplasmic content at 4 ug/ml after 48 hrs by TEM analysis | 2021 | Bioorganic & medicinal chemistry letters, 06-01, Volume: 41 | Inhibitory effects and mechanism of antifungal action of the natural cyclic depsipeptide, aureobasidin A against Cryptococcus neoformans. |
| AID1898175 | Antifungal activity against Candida glabrata ATCC2001 | |||
| AID416851 | Toxicity to human skin assessed as damage of skin integrity at 2 fold MIC administered 30 mins post inoculation followed by once in every 2 days for 7 days by scanning electron microscopy | 2007 | Antimicrobial agents and chemotherapy, Oct, Volume: 51, Issue:10 | Targeting the calcineurin pathway enhances ergosterol biosynthesis inhibitors against Trichophyton mentagrophytes in vitro and in a human skin infection model. |
| AID567426 | Antifungal activity against Rhodotorula mucilaginosa after 7 days by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | In vitro antifungal activities of isavuconazole and comparators against rare yeast pathogens. |
| AID642924 | Antifungal activity against Aspergillus flavus ATCC 204304 at 160 ug/ml | 2011 | ACS medicinal chemistry letters, May-12, Volume: 2, Issue:5 | Natural Product Based 6-Hydroxy-2,3,4,6-tetrahydropyrrolo[1,2-a]pyrimidinium Scaffold as A New Antifungal Template. |
| AID1595070 | Antifungal activity against Candida albicans assessed as inhibition zone at 20 ug/ml by disk diffusion method | 2019 | European journal of medicinal chemistry, May-15, Volume: 170 | Tetrazole hybrids and their antifungal activities. |
| AID1888273 | Antifungal activity against Candida albicans ATCC SC5314 assessed as change in squalene level at 4 ug/ml incubated for 48 hrs by LC-MS analysis | |||
| AID371467 | Antimicrobial activity against Candida albicans ATCC 10231 after 24 to 48 hrs after 24 hrs by disk diffusion method | 2008 | European journal of medicinal chemistry, Jul, Volume: 43, Issue:7 | Synthesis and biological activity of some new benzoxazoles. |
| AID521533 | Antifungal activity against Candida krusei clinical isolates after 48 hrs by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | In vitro and in vivo antifungal activities of T-2307, a novel arylamidine. |
| AID1818272 | Antifungal activity against Candida tropicalis ATCC 1369 assessed as reduction in fungal growth incubated for 72 hrs by CLSI protocol based broth microdilution method | |||
| AID678588 | Antifungal activity against Aspergillus flavus KCCM 11899 after 2 days by twofold broth dilution method | 2012 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 22, Issue:18 | Synthesis and antifungal activity of 1-thia-4b-aza-cyclopenta[b]fluorene-4,10-diones. |
| AID472406 | Antifungal activity against Candida albicans ATCC 90018 after 48 hrs by broth microdilution method | 2010 | Bioorganic & medicinal chemistry, Apr-15, Volume: 18, Issue:8 | Synthesis, anticonvulsant and antimicrobial activities of some new 2-acetylnaphthalene derivatives. |
| AID518145 | Antimicrobial activity against Cryptococcus gattii serotype B isolate RAM-15 assessed as concentration required for heteroresistance | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Heteroresistance of Cryptococcus gattii to fluconazole. |
| AID1383917 | Antifungal activity against Candida albicans ATCC 76615 after 24 hrs by NCCLS micro broth dilution method | 2018 | European journal of medicinal chemistry, Apr-25, Volume: 150 | Molecular interaction of novel benzothiazolyl triazolium analogues with calf thymus DNA and HSA-their biological investigation as potent antimicrobial agents. |
| AID549045 | Antifungal activity against Candida albicans CA2 after 48 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | In vitro activities of retigeric acid B alone and in combination with azole antifungal agents against Candida albicans. |
| AID1898199 | Inhibition of CYP51 in Candida albicans SC5314 assessed as sterol level at 4 ug/ml measured after 12 hrs by GC-MS analysis (Rvb = 25.23%) | |||
| AID469170 | Antifungal activity against Aspergillus flavus at MIC after 72 hrs by disk diffusion assay | 2010 | European journal of medicinal chemistry, Feb, Volume: 45, Issue:2 | Synthesis, anti-bacterial and anti-fungal activities of some novel Schiff bases containing 2,4-disubstituted thiazole ring. |
| AID1465978 | Antifungal activity against Candida parapsilosis ATCC 22019 after 44 hrs by broth dilution assay | 2017 | Bioorganic & medicinal chemistry, 06-01, Volume: 25, Issue:11 | Investigation of aryl isonitrile compounds with potent, broad-spectrum antifungal activity. |
| AID551059 | Antifungal activity against Aspergillus niger assessed as macroscopically visible colonies after 48 and 72 hrs by standard agar dilution method | 2011 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 21, Issue:1 | Microwave assisted one pot synthesis of some novel 2,5-disubstituted 1,3,4-oxadiazoles as antifungal agents. |
| AID351031 | Antimicrobial activity against Candida parapsilosis by broth microdilution method | 2009 | European journal of medicinal chemistry, Mar, Volume: 44, Issue:3 | 2-Acylhydrazino-5-arylpyrrole derivatives: synthesis and antifungal activity evaluation. |
| AID1674379 | Antifungal activity against Cryptococcus neoformans JEC21 by CLSI protocol-based broth serial dilution method | |||
| AID245566 | In vitro concentration required to inhibit 80% growth of Saccharomyces cerevisiae strain Y170 (CgCDR1 over-expressed) after 48 h | 2004 | Bioorganic & medicinal chemistry letters, Oct-18, Volume: 14, Issue:20 | Quinazolinone-based fungal efflux pump inhibitors. Part 1: Discovery of an (N-methylpiperazine)-containing derivative with activity in clinically relevant Candida spp. |
| AID547565 | Antifungal activity against Candida glabrata after 24 to 72 hrs by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | In vitro antifungal activities of bis(alkylpyridinium)alkane compounds against pathogenic yeasts and molds. |
| AID1904368 | Antifungal activity against FLC-resistant Candida albicans 632 assessed as fungal growth inhibition by CLSI based serial microbroth dilution method | 2022 | European journal of medicinal chemistry, Apr-05, Volume: 233 | Design, synthesis, and evaluation of novel 3-thiophene derivatives as potent fungistatic and fungicidal reagents based on a conformational restriction strategy. |
| AID598889 | Bactericidal activity against Staphylococcus epidermidis assessed as concentration required to less than 0.1% survival of organism after 2 hrs | 2011 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 21, Issue:12 | Novel fungicidal benzylsulfanyl-phenylguanidines. |
| AID1198421 | Anticandidal activity against Candida glabrata ATCC 90030 incubated at 37 degC for 24 hrs in presence of 8-((1-Benzyl-1H-1,2,3-triazol-4-yl)methoxy)quinoline by broth micro dilution method | 2015 | European journal of medicinal chemistry, Mar-26, Volume: 93 | Synthesis, QSAR and anticandidal evaluation of 1,2,3-triazoles derived from naturally bioactive scaffolds. |
| AID486424 | Antibacterial activity against Candida albicans NCIM 3100 after 72 hrs by disc diffusion method | 2010 | European journal of medicinal chemistry, Jun, Volume: 45, Issue:6 | Synthesis and biological evaluation of beta-chloro vinyl chalcones as inhibitors of TNF-alpha and IL-6 with antimicrobial activity. |
| AID1247374 | Antifungal activity against Aspergillus fumigatus 7544 after 48 hrs by serial dilution method | 2015 | European journal of medicinal chemistry, Sep-18, Volume: 102 | Design, synthesis, and structure-activity relationship studies of novel thienopyrrolidone derivatives with strong antifungal activity against Aspergillus fumigates. |
| AID1176265 | Antifungal activity against Microsporum gypseum after 2 to 7 days by serial plate dilution method | 2015 | Bioorganic & medicinal chemistry letters, Jan-15, Volume: 25, Issue:2 | Ionic liquid catalyzed synthesis of 2-(indole-3-yl)-thiochroman-4-ones and their novel antifungal activities. |
| AID1758027 | Inhibition of CYP51 in Candida albicans ATCC SC5314 assessed as ergosterol level at 0.125 ug/ml after 16 hrs by GC-MS analysis (Rvb = 98.3%) | 2021 | European journal of medicinal chemistry, Apr-15, Volume: 216 | Lead optimization generates selenium-containing miconazole CYP51 inhibitors with improved pharmacological profile for the treatment of fungal infections. |
| AID1885968 | Antifungal activity against Cryptococcus neoformans clinical isolate HN15 assessed as fungal growth inhibition incubated for 72 hrs by broth microdilution method | |||
| AID1198412 | Fungicidal activity against Candida glabrata ATCC 90030 incubated at 37 degC for 48 hrs by broth dilution method | 2015 | European journal of medicinal chemistry, Mar-26, Volume: 93 | Synthesis, QSAR and anticandidal evaluation of 1,2,3-triazoles derived from naturally bioactive scaffolds. |
| AID535687 | Antibacterial activity against Cryptococcus neoformans serotype D after 72 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Antifungal susceptibilities among different serotypes of Cryptococcus gattii and Cryptococcus neoformans. |
| AID1754263 | Antifungal activity against Cryptococcus neoformans ATCC 32609 by microplate reader assay | 2021 | Bioorganic & medicinal chemistry, 07-01, Volume: 41 | A new sulfated triterpene glycoside from the sea cucumber Colochirus quadrangularis, and evaluation of its antifungal, antitumor and immunomodulatory activities. |
| AID1311672 | Antifungal activity against Candida albicans MTCC 3017 assessed as zone of inhibition at 100 ug/well measured after 48 hrs by agar well diffusion method | 2016 | Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15 | Synthesis, characterization and antimicrobial activity of novel Schiff base tethered boronate esters of 1,2-O-isopropylidene-α-d-xylofuranose. |
| AID1864955 | Antiinflammatory activity in mouse infected with Candida albicans ATCC SC5314 assessed as reduction in COX-2 expression in spleen in presence of naproxen by hematoxylin staining based inverted microscopic analysis | |||
| AID274125 | Antifungal activity against Microsporum canis after 7 days | 2006 | Bioorganic & medicinal chemistry letters, Oct-15, Volume: 16, Issue:20 | Design, synthesis, and antifungal activities in vitro of novel tetrahydroisoquinoline compounds based on the structure of lanosterol 14alpha-demethylase (CYP51) of fungi. |
| AID429399 | Antifungal activity against Candida tropicalis MTCC 230 after 24 to 72 hrs by broth dilution method | 2009 | European journal of medicinal chemistry, Aug, Volume: 44, Issue:8 | Mechanism of unusual formation of 3-(5-phenyl-3H-[1,2,4]dithiazol-3-yl)chromen-4-ones and 4-oxo-4H-chromene-3-carbothioic acid N-phenylamides and their antimicrobial evaluation. |
| AID691709 | Antifungal activity against Microsporum gypseum MTCC 4490 after 24 hrs by serial dilution method | 2012 | Bioorganic & medicinal chemistry letters, Oct-15, Volume: 22, Issue:20 | Synthesis of β-ionone derived chalcones as potent antimicrobial agents. |
| AID519058 | Antifungal activity against Candida krusei assessed as susceptible isolates after 48 hrs by broth microdilution | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | Antimicrobial activity of omiganan pentahydrochloride against contemporary fungal pathogens responsible for catheter-associated infections. |
| AID1592218 | Antifungal activity against Aspergillus fumigatus KM8001 assessed as inhibition of microbial growth by NCCLS protocol based method | 2019 | Bioorganic & medicinal chemistry, 06-15, Volume: 27, Issue:12 | Design, synthesis and biological evaluation of amide-pyridine derivatives as novel dual-target (SE, CYP51) antifungal inhibitors. |
| AID662995 | Growth inhibition of Mycobacterium tuberculosis H37Rv at 250 ug/mL | 2012 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 22, Issue:12 | An improved microwave assisted one-pot synthesis, and biological investigations of some novel aryldiazenyl chromeno fused pyrrolidines. |
| AID1254329 | Antifungal activity against Trichophyton mentagrophytes 445 after 48 hrs by microdilution broth method | 2015 | Bioorganic & medicinal chemistry, Nov-15, Volume: 23, Issue:22 | Novel derivatives of nitro-substituted salicylic acids: Synthesis, antimicrobial activity and cytotoxicity. |
| AID1287094 | Antimicrobial activity against antibiotic resistant Candida albicans clinical isolate 08022710 after 16 hrs by broth dilution method | 2016 | Journal of medicinal chemistry, Mar-10, Volume: 59, Issue:5 | A Designed Tryptophan- and Lysine/Arginine-Rich Antimicrobial Peptide with Therapeutic Potential for Clinical Antibiotic-Resistant Candida albicans Vaginitis. |
| AID1549163 | Inhibition of HDAC in HUVEC using Boc-Lys(Ac)-AMC as substrate preincubated for 12 hrs followed by substrate addition and measured after 4 hrs by fluorimetry | 2020 | Journal of medicinal chemistry, 05-28, Volume: 63, Issue:10 | Discovery of Novel Fungal Lanosterol 14α-Demethylase (CYP51)/Histone Deacetylase Dual Inhibitors to Treat Azole-Resistant Candidiasis. |
| AID425165 | Antifungal activity against Candida glabrata isolate 4293 after 48 hrs by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | Posaconazole activity against Candida glabrata after exposure to caspofungin or amphotericin B. |
| AID1254075 | Antibacterial activity against Salmonella typhimurium 2421 after 24 hrs by two-fold serial dilution method | 2015 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 25, Issue:22 | Synthesis and biological evaluation of 1,3-diaryl pyrazole derivatives as potential antibacterial and anti-inflammatory agents. |
| AID1861418 | Antifungal activity against fluconazole-resistant Candida albicans SC5314FR assessed as inhibition of fungal growth by microdilution method | 2022 | Bioorganic & medicinal chemistry letters, 09-01, Volume: 71 | Discovery of novel indole and indoline derivatives against Candida albicans as potent antifungal agents. |
| AID1357638 | Cytotoxicity against human HEK293 cells after 72 hrs by MTT assay | 2018 | European journal of medicinal chemistry, May-10, Volume: 151 | Synthesis, molecular modeling studies and evaluation of antifungal activity of a novel series of thiazole derivatives. |
| AID1546138 | Antifungal activity against Candida utilis after 24 hrs | 2019 | European journal of medicinal chemistry, Dec-15, Volume: 184 | Current scenario of tetrazole hybrids for antibacterial activity. |
| AID1549141 | Antifungal activity against azole-sensitive Cryptococcus neoformans H99 after 72 hrs by spectrophotometry-based serial microdilution method | 2020 | Journal of medicinal chemistry, 05-28, Volume: 63, Issue:10 | Discovery of Novel Fungal Lanosterol 14α-Demethylase (CYP51)/Histone Deacetylase Dual Inhibitors to Treat Azole-Resistant Candidiasis. |
| AID527142 | Antifungal activity against Candida parapsilosis LMGO 05 after 5 days microdilution technique | 2010 | Journal of natural products, Oct-22, Volume: 73, Issue:10 | Search for antifungal compounds from the wood of durable tropical trees. |
| AID1758011 | Antifungal activity against fluconazole-resistant Candida albicans 632 assessed as inhibition of microbial growth after 24 hrs by broth microdilution method | 2021 | European journal of medicinal chemistry, Apr-15, Volume: 216 | Lead optimization generates selenium-containing miconazole CYP51 inhibitors with improved pharmacological profile for the treatment of fungal infections. |
| AID283842 | Antifungal activity against Aspergillus fumigatus NCIM no. 902 after 3 to 4 days by serial plate dilution method | 2007 | European journal of medicinal chemistry, Jan, Volume: 42, Issue:1 | Synthesis and antimicrobial studies on novel chloro-fluorine containing hydroxy pyrazolines. |
| AID1254321 | Antifungal activity against Candida glabrata 20/I after 48 hrs by microdilution broth method | 2015 | Bioorganic & medicinal chemistry, Nov-15, Volume: 23, Issue:22 | Novel derivatives of nitro-substituted salicylic acids: Synthesis, antimicrobial activity and cytotoxicity. |
| AID365069 | Antifungal activity against Microsporum canis FF1 after 5 days by broth macrodilution method | 2008 | Bioorganic & medicinal chemistry, Sep-01, Volume: 16, Issue:17 | Antifungal activity of synthetic di(hetero)arylamines based on the benzo[b]thiophene moiety. |
| AID486420 | Antibacterial activity against Aspergillus niger NCIM 545 after 72 hrs by disc diffusion method | 2010 | European journal of medicinal chemistry, Jun, Volume: 45, Issue:6 | Synthesis and biological evaluation of beta-chloro vinyl chalcones as inhibitors of TNF-alpha and IL-6 with antimicrobial activity. |
| AID582239 | Antifungal activity against Candida albicans isolated from HSCT recipients with acute or chronic GVHD prior to initiation of fluconazole therapy by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Impact of antifungal prophylaxis on colonization and azole susceptibility of Candida species. |
| AID521500 | Antifungal activity against Candida parapsilosis NBRC 10219 after 48 hrs by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | In vitro and in vivo antifungal activities of T-2307, a novel arylamidine. |
| AID388082 | Antifungal activity at Cryptococcus neoformans | 2008 | Bioorganic & medicinal chemistry letters, Oct-15, Volume: 18, Issue:20 | Synthesis of chimeric tetrapeptide-linked cholic acid derivatives: impending synergistic agents. |
| AID549309 | Antifungal activity against Candida albicans ATCC 10231 by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | In vitro activities of retigeric acid B alone and in combination with azole antifungal agents against Candida albicans. |
| AID1904383 | Disruption of membrane integrity in Candida albicans ATCC SC5314 assessed as cell membrane damage at 16 ug/ml incubated for 48 hrs by transmission electron microscopy | 2022 | European journal of medicinal chemistry, Apr-05, Volume: 233 | Design, synthesis, and evaluation of novel 3-thiophene derivatives as potent fungistatic and fungicidal reagents based on a conformational restriction strategy. |
| AID398057 | Antifungal activity against Saccharomyces cerevisiae DSY 390 after 40 to 48 hrs by serial dilution method | 2003 | Journal of natural products, Dec, Volume: 66, Issue:12 | Reversal of fluconazole resistance in multidrug efflux-resistant fungi by the Dysidea arenaria sponge sterol 9alpha,11alpha-epoxycholest-7-ene-3beta,5alpha,6alpha,19-tetrol 6-acetate. |
| AID555584 | Antimicrobial activity against Candida zeylanoides by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Activity profile in vitro of micafungin against Spanish clinical isolates of common and emerging species of yeasts and molds. |
| AID50320 | Compound was tested in vitro for antifungal activity against Cryptococcus neoformans (CY1057) in experiment 2 | 1998 | Bioorganic & medicinal chemistry letters, Jul-21, Volume: 8, Issue:14 | Modeling, synthesis and biological activity of novel antifungal agents (1). |
| AID584400 | Antifungal activity against 35 days cultured Candida glabrata isolated from HSCT recipient with acute or chronic GVHD mouth receiving antifungal therapy for 165 days after 138 days of prophylaxis by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Impact of antifungal prophylaxis on colonization and azole susceptibility of Candida species. |
| AID613452 | Antifungal activity against Candida albicans isolate NCL1 after 48 hrs by broth dilution method | 2011 | European journal of medicinal chemistry, Sep, Volume: 46, Issue:9 | Stereoselective synthesis and antimicrobial activity of steroidal C-20 tertiary alcohols with thiazole/pyridine side chain. |
| AID1334852 | Anti-fungal activity against fluconazole-resistant Candida albicans 100 by broth microdilution method | 2017 | Bioorganic & medicinal chemistry, 01-15, Volume: 25, Issue:2 | Discovery of biphenyl imidazole derivatives as potent antifungal agents: Design, synthesis, and structure-activity relationship studies. |
| AID566727 | Antifungal activity against Candida tropicalis after 24 hrs by MTT assay | 2011 | European journal of medicinal chemistry, Jan, Volume: 46, Issue:1 | Synthesis and biological evaluation of novel 2,4-disubstituted-1,3-thiazoles as anti-Candida spp. agents. |
| AID1392826 | Inhibition of Cyp51 in Candida albicans ATCC SC5314 assessed as eburicol content at 0.125 ug/ml after 16 hrs by GC-MS analysis (Rvb = 0.4%) | 2018 | Bioorganic & medicinal chemistry, 07-23, Volume: 26, Issue:12 | Design, synthesis and evaluation of benzoheterocycle analogues as potent antifungal agents targeting CYP51. |
| AID1179571 | Antifungal activity against fluconazole-resistant Candida albicans at 100 ug/well after 24 hrs by well diffusion assay | 2014 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 24, Issue:15 | Synthesis and SAR study of novel anticancer and antimicrobial naphthoquinone amide derivatives. |
| AID665133 | Antifungal activity against 4 strains of Candida glabrata after 24 hrs by EUCAST broth microdilution method | 2012 | European journal of medicinal chemistry, Jul, Volume: 53 | Synthesis, anti-Candida activity, and cytotoxicity of new (4-(4-iodophenyl)thiazol-2-yl)hydrazine derivatives. |
| AID457987 | Antifungal activity against Candida tropicalis 156 after 24 hrs by microdilution method | 2010 | Bioorganic & medicinal chemistry, Mar-01, Volume: 18, Issue:5 | Antifungal 3,5-disubstituted furanones: From 5-acyloxymethyl to 5-alkylidene derivatives. |
| AID594998 | Antifungal activity against Penicillium marneffei after 48 hrs by Halo zone test | 2011 | Bioorganic & medicinal chemistry letters, May-15, Volume: 21, Issue:10 | Thermal solvent-free synthesis of novel pyrazolyl chalcones and pyrazolines as potential antimicrobial agents. |
| AID581873 | Antifungal activity against Candida glabrata isolated from neutropenic subject 1187 with AML or MDS stool receiving antifungal drug after 22 days prophylaxis by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Impact of antifungal prophylaxis on colonization and azole susceptibility of Candida species. |
| AID525400 | Antifungal activity against Candida glabrata isolate 4198 after 48 hrs by microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Posaconazole against Candida glabrata isolates with various susceptibilities to fluconazole. |
| AID519678 | Antimicrobial activity against Saccharomyces cerevisiae containing disruption in RTG2 gene by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Genomewide screening for genes associated with gliotoxin resistance and sensitivity in Saccharomyces cerevisiae. |
| AID567431 | Antifungal activity against Rhodotorula mucilaginosa after 48 hrs by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | In vitro antifungal activities of isavuconazole and comparators against rare yeast pathogens. |
| AID1738744 | Inhibition of CYP51 in azole-resistant Candida albicans ATCC SC531 assessed as Eburicol level at 0.125 ug/ml incubated for 16 hrs by LC-MS analysis relative to control | 2020 | European journal of medicinal chemistry, Jul-15, Volume: 198 | Design, synthesis, and biological evaluation of novel miconazole analogues containing selenium as potent antifungal agents. |
| AID467904 | Antifungal activity against Cryptococcus neoformans after 48 hrs by broth microdilution technique | 2010 | European journal of medicinal chemistry, Feb, Volume: 45, Issue:2 | Imidazole derivatives as possible microbicides with dual protection. |
| AID49634 | Minimum inhibitory concentration of compound for antifungal activity against Candida albicans 2 | 2000 | Bioorganic & medicinal chemistry letters, Oct-02, Volume: 10, Issue:19 | Novel antifungals based on 4-substituted imidazole: a combinatorial chemistry approach to lead discovery and optimization. |
| AID1755827 | Antimicrobial activity against Candida parapsilosis ATCC 22019 | 2021 | European journal of medicinal chemistry, Jan-15, Volume: 210 | Metronidazole-conjugates: A comprehensive review of recent developments towards synthesis and medicinal perspective. |
| AID490330 | Antimicrobial activity against Staphylococcus aureus ATCC 29213 after 24 hrs by microdilution assay | 2010 | European journal of medicinal chemistry, Jul, Volume: 45, Issue:7 | Synthesis and biological evaluation of some thio containing pyrrolo [2,3-d]pyrimidine derivatives for their anti-inflammatory and anti-microbial activities. |
| AID518138 | Antimicrobial activity against Cryptococcus gattii serotype B isolate RB-26 assessed as concentration required for heteroresistance | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Heteroresistance of Cryptococcus gattii to fluconazole. |
| AID532952 | Antifungal activity against Candida albicans isolate V2 with CAI genotype by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | Correlation between azole susceptibilities, genotypes, and ERG11 mutations in Candida albicans isolates associated with vulvovaginal candidiasis in China. |
| AID1239800 | Antifungal activity against Candida albicans ATCC 10231 at 100 ug/ml after 48 hrs by cup plate method | 2015 | Bioorganic & medicinal chemistry letters, Sep-01, Volume: 25, Issue:17 | Design, synthesis and evaluation of benzotriazole derivatives as novel antifungal agents. |
| AID1199844 | Inhibition of Vps75-stimulated recombinant Saccharomyces cerevisiae histone acetyltransferase Rtt109 using Asf1-dH3-H4 as substrate assessed as coenzyme A production after 45 mins by CPM based HTS assay | 2015 | Journal of medicinal chemistry, Mar-12, Volume: 58, Issue:5 | PAINS in the assay: chemical mechanisms of assay interference and promiscuous enzymatic inhibition observed during a sulfhydryl-scavenging HTS. |
| AID1732429 | Antifungal activity against Candida albicans ATCC 90028 assessed as growth inhibition after 36 hrs by monochromator plate assay | 2021 | Bioorganic & medicinal chemistry letters, 05-01, Volume: 39 | Design, synthesis and bioactivity evaluation of novel pyrazole linked phenylthiazole derivatives in context of antibacterial activity. |
| AID525398 | Antifungal activity against Candida parapsilosis ATCC 22019 after 48 hrs by microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Posaconazole against Candida glabrata isolates with various susceptibilities to fluconazole. |
| AID1244342 | Antifungal activity against Candida albicans incubated for 48 hrs by broth micro-dilution method | 2015 | European journal of medicinal chemistry, Aug-28, Volume: 101 | N-Alkyl/aryl-4-(3-substituted-3-phenylpropyl)piperazine-1-carbothioamide as dual-action vaginal microbicides with reverse transcriptase inhibition. |
| AID529546 | Antifungal activity against Candida glabrata 06-3170 harboring FSK1p T1896G and D632E mutant obtained from patient on compound therapy by M27-A2 method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Reduced Candida glabrata susceptibility secondary to an FKS1 mutation developed during candidemia treatment. |
| AID737322 | Antimicrobial activity against Aspergillus terreus MTCC 1782 at 1000 ug/ml after 72 hrs by cup plate method | 2013 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 23, Issue:7 | Synthesis of novel 2-amino-4-(5'-substituted 2'-phenyl-1H-indol-3'-yl)-6-aryl-4H-pyran-3-carbonitrile derivatives as antimicrobial and antioxidant agents. |
| AID555599 | Antimicrobial activity against Cryptococcus laurentii by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Activity profile in vitro of micafungin against Spanish clinical isolates of common and emerging species of yeasts and molds. |
| AID563117 | Antifungal activity against Candida glabrata ATCC 90030 after 48 hrs by broth microdilution method in presence of 0.1% glucose | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | T-2307 shows efficacy in a murine model of Candida glabrata infection despite in vitro trailing growth phenomena. |
| AID609980 | Antifungal activity against Penicillium notatum sp. at 1000 ug after 24 hrs by paper disc technique | 2011 | Bioorganic & medicinal chemistry letters, Aug-15, Volume: 21, Issue:16 | Efficient synthesis of antifungal active 9-substituted-3-aryl-5H,13aH-quinolino[3,2-f][1,2,4]triazolo[4,3-b][1,2,4]triazepines in ionic liquids. |
| AID1754369 | Antifungal activity against Lichtheimia corymbifera CCM 8077 assessed as reduction in fungal growth incubated for 48 hrs by broth microdilution method based spectrophotometric analysis | 2021 | Bioorganic & medicinal chemistry, 07-01, Volume: 41 | Iodinated 1,2-diacylhydrazines, benzohydrazide-hydrazones and their analogues as dual antimicrobial and cytotoxic agents. |
| AID574600 | Antifungal activity against Candida tropicalis 156 after 24 hrs by broth microdilution method | 2011 | Bioorganic & medicinal chemistry, Feb-15, Volume: 19, Issue:4 | Synthesis and antimycobacterial properties of N-substituted 6-amino-5-cyanopyrazine-2-carboxamides. |
| AID582228 | Antifungal activity against Candida albicans isolated from neutropenic subjects with AML or MDS prior to initiation of posaconazole therapy by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Impact of antifungal prophylaxis on colonization and azole susceptibility of Candida species. |
| AID42685 | In vitro antifungal activity against Candida parapsilosis 2372E | 2002 | Journal of medicinal chemistry, Oct-24, Volume: 45, Issue:22 | Synthesis, antifungal activity, and molecular modeling studies of new inverted oxime ethers of oxiconazole. |
| AID1419523 | Effect on sterol composition in Candida albicans ATCC 10231 assessed as ergosterol level at 0.125 ug/mL incubated for 10 mins by LC-MS analysis (Rvb = 91.15%) | 2017 | European journal of medicinal chemistry, Jun-16, Volume: 133 | Novel alkylated azoles as potent antifungals. |
| AID518881 | Antimicrobial activity against Cryptococcus gattii serotype B isolate NIH286 assessed as heteroresistant isolates at 32 ug/ml | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Heteroresistance of Cryptococcus gattii to fluconazole. |
| AID1328361 | Antifungal activity against Cryptococcus gattii ATCC 32609 assessed as growth inhibition measured after 72 hrs by CLSI method | 2016 | Journal of natural products, 09-23, Volume: 79, Issue:9 | Synthesis of Natural Acylphloroglucinol-Based Antifungal Compounds against Cryptococcus Species. |
| AID1079945 | Animal toxicity known. [column 'TOXIC' in source] | |||
| AID405036 | Antifungal activity against Sporothrix schenckii P24255 isolate from cutaneous-lymphatic sporotrichosis patient after 72 hrs by modified NCCLS M38-A method | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | In vitro susceptibility of Sporothrix schenckii to six antifungal agents determined using three different methods. |
| AID407004 | Antimicrobial activity against Candida albicans FH1 at planktonic cell density of 10'8 cells/ml after 48 hrs by XTT assay | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | Role for cell density in antifungal drug resistance in Candida albicans biofilms. |
| AID1168331 | Binding affinity to human serum albumin at 302 K by Scatchard method | 2014 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 24, Issue:21 | Study the interactions between human serum albumin and two antifungal drugs: fluconazole and its analogue DTP. |
| AID977602 | Inhibition of sodium fluorescein uptake in OATP1B3-transfected CHO cells at an equimolar substrate-inhibitor concentration of 10 uM | 2013 | Molecular pharmacology, Jun, Volume: 83, Issue:6 | Structure-based identification of OATP1B1/3 inhibitors. |
| AID1154815 | Antifungal activity against Candida parapsilosis ATCC 22019 after 24 hrs by serial dilution method | 2014 | ACS medicinal chemistry letters, May-08, Volume: 5, Issue:5 | Novel carboline derivatives as potent antifungal lead compounds: design, synthesis, and biological evaluation. |
| AID470598 | Antifungal activity against Sporothrix schenckii after 72 hrs by microbroth dilution technique | 2009 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 19, Issue:18 | Design and synthesis of bile acid-based amino sterols as antimicrobial agents. |
| AID1271240 | Antifungal activity against Candida glabrata NCYC 388 after 72 hrs by broth microdilution method | 2015 | ACS medicinal chemistry letters, Nov-12, Volume: 6, Issue:11 | Silicon Incorporated Morpholine Antifungals: Design, Synthesis, and Biological Evaluation. |
| AID1689817 | Antifungal activity against fluconazole-resistant Candida albicans DSY735 over expression of CDR1/CDR2 assessed as reduction in microbial growth after 24 hrs by resazurin staining based spectrofluorometric method | 2020 | European journal of medicinal chemistry, Mar-01, Volume: 189 | New azole antifungals with a fused triazinone scaffold. |
| AID555578 | Antimicrobial activity against Candida norvegensis by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Activity profile in vitro of micafungin against Spanish clinical isolates of common and emerging species of yeasts and molds. |
| AID283234 | Antifungal activity against Coccidioides immitis by broth macrodilution method | 2007 | Antimicrobial agents and chemotherapy, Mar, Volume: 51, Issue:3 | Comparison of itraconazole and fluconazole treatments in a murine model of coccidioidal meningitis. |
| AID521495 | Antifungal activity against Candida albicans TIMM 1623 after 48 hrs by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | In vitro and in vivo antifungal activities of T-2307, a novel arylamidine. |
| AID1059350 | Fungicidal activity against Candida albicans clinical isolate by micro dilution method | 2013 | European journal of medicinal chemistry, , Volume: 70 | Designing and synthesis of novel antimicrobial heterocyclic analogs of fatty acids. |
| AID1770938 | Antifungal activity against Candida albicans CPCC400616 assessed as fungal growth inhibition by CLSI protocol based method | 2021 | European journal of medicinal chemistry, Dec-05, Volume: 225 | Design, synthesis and evaluation of novel 5-phenylthiophene derivatives as potent fungicidal of Candida albicans and antifungal reagents of fluconazole-resistant fungi. |
| AID531244 | Antifungal activity against Candida guilliermondii assessed as susceptible isolates after 48 hrs by CLSI method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | In vitro susceptibilities of invasive isolates of Candida species: rapid increase in rates of fluconazole susceptible-dose dependent Candida glabrata isolates. |
| AID569365 | Antifungal activity against Aspergillus flavus at 500 ug after 24 hrs by paper disc technique | 2011 | European journal of medicinal chemistry, Feb, Volume: 46, Issue:2 | Efficient and novel one-pot synthesis of antifungal active 1-substituted-8-aryl-3-alkyl/aryl-4H-pyrazolo[4,5-f][1,2,4]triazolo[4,3-b][1,2,4]triazepines using solid support. |
| AID279103 | Mortality rate in Candida parapsilosis infected candidemia patient | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Association of fluconazole area under the concentration-time curve/MIC and dose/MIC ratios with mortality in nonneutropenic patients with candidemia. |
| AID47245 | In vitro antifungal activity against Candida albicans CY 1002 | 2000 | Bioorganic & medicinal chemistry letters, Jul-03, Volume: 10, Issue:13 | Synthesis and structure-activity relationships of novel fungal chitin synthase inhibitors. |
| AID1380519 | Antifungal activity against Candida albicans DSY296 assessed as inhibition of fungal growth incubated for 48 hrs by broth microdilution assay | 2018 | Bioorganic & medicinal chemistry letters, 06-01, Volume: 28, Issue:10 | Biofilm inhibition and anti-Candida activity of a cationic lipo-benzamide molecule with twin-nonyl chain. |
| AID415955 | Antimicrobial activity against Aspergillus fumigatus by micro-broth dilution method | 2009 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 19, Issue:6 | Design, synthesis, and biological evaluation of novel 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-substituted benzylamino-2-propanols. |
| AID1063948 | Antifungal activity against Aspergillus fumigatus 231 after 24 hrs by broth microdilution method | 2014 | Bioorganic & medicinal chemistry, Jan-15, Volume: 22, Issue:2 | Salicylanilide diethyl phosphates: synthesis, antimicrobial activity and cytotoxicity. |
| AID555587 | Antimicrobial activity against Yarrowia lipolytica by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Activity profile in vitro of micafungin against Spanish clinical isolates of common and emerging species of yeasts and molds. |
| AID1877831 | Antifungal activity against Candida albicans ATCC14053 by microdilution method | 2022 | Bioorganic & medicinal chemistry letters, 02-15, Volume: 58 | Synthesis and antifungal evaluation of phenol-derived bis(indolyl)methanes combined with FLC against Candida albicans. |
| AID665400 | Antifungal activity against Candida albicans MTCC 183 after 72 hrs by serial dilution technique | 2012 | European journal of medicinal chemistry, Jul, Volume: 53 | Synthesis, characterization, antimicrobial activities and QSAR studies of some 10a-phenylbenzo[b]indeno[1,2-e][1,4]thiazin-11(10aH)-ones. |
| AID1689832 | Inhibition of sterol biosynthesis in Candida albicans CAAL93 assessed as fecosterol level at 10 ng/ml after 18 hrs by GC-MS analysis relative to control | 2020 | European journal of medicinal chemistry, Mar-01, Volume: 189 | New azole antifungals with a fused triazinone scaffold. |
| AID1918342 | Inhibition of CYP51 in Candida albicans ATCC SC5314 assessed as reduction in substrate consumption using lanosterol as substrate preincubated for 30 mins followed by substrate addition and measured after 60 mins by HPLC analysis | 2022 | Journal of medicinal chemistry, 11-10, Volume: 65, Issue:21 | Novel Aryl Alkamidazole Derivatives as Multifunctional Antifungal Inhibitors: Design, Synthesis, and Biological Evaluation. |
| AID372244 | Fungistatic activity against Candida albicans CHK23 after 24 to 48 hrs by broth microdilution assay | 2007 | Antimicrobial agents and chemotherapy, Oct, Volume: 51, Issue:10 | The Ssk1p response regulator and Chk1p histidine kinase mutants of Candida albicans are hypersensitive to fluconazole and voriconazole. |
| AID1681018 | Antifungal activity against Aspergillus niger assessed as diameter of inhibition zone at 1 mg/ml incubated for 24 hrs by agar well diffusion assay | 2020 | Bioorganic & medicinal chemistry letters, 10-01, Volume: 30, Issue:19 | Novel isoniazid embedded triazole derivatives: Synthesis, antitubercular and antimicrobial activity evaluation. |
| AID434897 | Antifungal activity against Candida tropicalis isolate 13 in RPMI 1640 medium by broth dilution susceptibility test | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | In vitro study of Candida tropicalis isolates exhibiting paradoxical growth in the presence of high concentrations of caspofungin. |
| AID582791 | Antifungal activity against Candida albicans isolate 6 assessed as eburicol content in total sterol composition at 0.5 times MIC by GC-MS analysis | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | Identification and characterization of four azole-resistant erg3 mutants of Candida albicans. |
| AID285861 | Antimicrobial susceptibility of Pichia anomala from nosocomial fungemia patient assessed as percent susceptible isolates at 8 ug/ml by CLSI method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Antifungal drug susceptibility profile of Pichia anomala isolates from patients presenting with nosocomial fungemia. |
| AID1201582 | Antifungal activity against Aspergillus flavus at 1 mg/ml incubated for 3 days | 2015 | European journal of medicinal chemistry, May-05, Volume: 95 | Synthesis and biological evaluation of new imidazo[2,1-b][1,3,4]thiadiazole-benzimidazole derivatives. |
| AID424905 | Antimicrobial activity against azole-resistant Candida albicans isolate CA10 assessed as growth at 8 ug/ml co-treated with 0.008 ug/ml calcineurin signaling inhibitor tacrolimus after 48 hrs by microdilution checkboard technique relative to control | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | In vitro interactions between tacrolimus and azoles against Candida albicans determined by different methods. |
| AID518418 | Antimicrobial activity against Cryptococcus gattii serotype C isolate NIH34 assessed as heteroresistant isolates at 2 ug/ml | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Heteroresistance of Cryptococcus gattii to fluconazole. |
| AID551058 | Antifungal activity against Aspergillus flavus assessed as macroscopically visible colonies after 48 and 72 hrs by standard agar dilution method | 2011 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 21, Issue:1 | Microwave assisted one pot synthesis of some novel 2,5-disubstituted 1,3,4-oxadiazoles as antifungal agents. |
| AID574607 | Antifungal activity against Trichophyton mentagrophytes 445 after 120 hrs by broth microdilution method | 2011 | Bioorganic & medicinal chemistry, Feb-15, Volume: 19, Issue:4 | Synthesis and antimycobacterial properties of N-substituted 6-amino-5-cyanopyrazine-2-carboxamides. |
| AID1369455 | Antifungal activity against Candida parapsilosis cgmcc 2.3989 after 48 hrs by broth microdilution method | 2018 | Journal of medicinal chemistry, 05-10, Volume: 61, Issue:9 | Combating Drug-Resistant Fungi with Novel Imperfectly Amphipathic Palindromic Peptides. |
| AID538382 | Antifungal activity against Candida albicans by serial dilution method | 2010 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 20, Issue:23 | Synthesis and in vitro antifungal activities of new 3-substituted benzopyrone derivatives. |
| AID1609946 | Cytotoxicity against human A549 cells assessed as cell survival at 2 uM/l incubated for 24 hrs by MTT assay relative to control | |||
| AID537527 | Antifungal activity against Candida krusei after 48 hrs by broth microdilution method | 2010 | Bioorganic & medicinal chemistry, Nov-15, Volume: 18, Issue:22 | Synthesis of new antifungal peptides selective against Cryptococcus neoformans. |
| AID42868 | Inhibition of Candida glabrata 20/I growth for 24 hours in vitro. | 2001 | Journal of medicinal chemistry, Aug-16, Volume: 44, Issue:17 | 3-Phenyl-5-acyloxymethyl-2H,5H-furan-2-ones: synthesis and biological activity of a novel group of potential antifungal drugs. |
| AID1369458 | Fungicidal activity against Candida albicans SP3903 after 96 hrs | 2018 | Journal of medicinal chemistry, 05-10, Volume: 61, Issue:9 | Combating Drug-Resistant Fungi with Novel Imperfectly Amphipathic Palindromic Peptides. |
| AID308610 | Antifungal activity against Aspergillus fumigatus | 2007 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 17, Issue:15 | Antifungal activity in triterpene glycosides from the sea cucumber Actinopyga lecanora. |
| AID50140 | Evaluation of In vitro antifungal activity against Candida krusei 70 by broth macro dilution method | 1995 | Journal of medicinal chemistry, Sep-29, Volume: 38, Issue:20 | Synthesis and antifungal activity of new azole derivatives containing an N-acylmorpholine ring. |
| AID1758005 | Antifungal activity against Candida krusei AS2.1045 measured after 24 hrs by broth microdilution assay | 2021 | European journal of medicinal chemistry, Apr-15, Volume: 216 | Lead optimization generates selenium-containing miconazole CYP51 inhibitors with improved pharmacological profile for the treatment of fungal infections. |
| AID1487222 | Inhibition of CYP11B2 in human hepatocyte microsomes using deoxycorticosteroid substrate by HPLC/MS/MS method | 2017 | Bioorganic & medicinal chemistry letters, 08-01, Volume: 27, Issue:15 | Design and optimization of highly-selective, broad spectrum fungal CYP51 inhibitors. |
| AID356362 | Antifungal activity against fluconazole-resistant Candida albicans isolate 8 after 24 to 48 hrs by NCCLS method | 2003 | Journal of natural products, Aug, Volume: 66, Issue:8 | Acetylenic acids inhibiting azole-resistant Candida albicans from Pentagonia gigantifolia. |
| AID594126 | Antifungal activity against Candida krusei ATCC 200298 after 24 hrs | 2011 | European journal of medicinal chemistry, May, Volume: 46, Issue:5 | Pyridine-derived thiosemicarbazones and their tin(IV) complexes with antifungal activity against Candida spp. |
| AID1198426 | Toxicity in human RBC assessed as induction of hemolysis at 500 ug/ml incubated for 1 hr by spectrophotometry | 2015 | European journal of medicinal chemistry, Mar-26, Volume: 93 | Synthesis, QSAR and anticandidal evaluation of 1,2,3-triazoles derived from naturally bioactive scaffolds. |
| AID1918336 | Antifungal activity against Aspergillus fumigatus KM8001 assessed as inhibition of fungal growth measured after 72 hrs by CLSI based liquid medium dilution method | 2022 | Journal of medicinal chemistry, 11-10, Volume: 65, Issue:21 | Novel Aryl Alkamidazole Derivatives as Multifunctional Antifungal Inhibitors: Design, Synthesis, and Biological Evaluation. |
| AID1419531 | Effect on sterol composition in Candida albicans ATCC 64124 assessed as unknown sterol level at 0.125 ug/mL incubated for 10 mins by LC-MS analysis (Rvb = 2.67 to 6.98%) | 2017 | European journal of medicinal chemistry, Jun-16, Volume: 133 | Novel alkylated azoles as potent antifungals. |
| AID1820670 | Inhibition of CYP51 in Candida albicans SC5314 assessed as eburicol level at 0.25 ug/ml measured after 18 hrs by GC-MS analysis | 2022 | European journal of medicinal chemistry, Jan-15, Volume: 228 | Design, synthesis, and biological activity evaluation of 2-(benzo[b]thiophen-2-yl)-4-phenyl-4,5-dihydrooxazole derivatives as broad-spectrum antifungal agents. |
| AID1497598 | Antifungal activity against fluconazole-resistant Candida albicans isolate 28 after 24 hrs by broth microdilution method | 2018 | Bioorganic & medicinal chemistry letters, 07-15, Volume: 28, Issue:13 | Benzofuro[3,2-d]pyrimidines inspired from cercosporamide CaPkc1 inhibitor: Synthesis and evaluation of fluconazole susceptibility restoration. |
| AID519497 | Antifungal activity against Candida albicans isolates after 48 hrs by CLSI M27-A2 procedure based assay | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | In vitro antifungal activities of isavuconazole (BAL4815), voriconazole, and fluconazole against 1,007 isolates of zygomycete, Candida, Aspergillus, Fusarium, and Scedosporium species. |
| AID1138333 | Antimicrobial activity against fluconazole-resistant Candida albicans 100 after 24 hrs by serial dilution method | 2014 | Journal of medicinal chemistry, May-08, Volume: 57, Issue:9 | Design, synthesis, and structure-activity relationship studies of novel fused heterocycles-linked triazoles with good activity and water solubility. |
| AID592681 | Apparent permeability across human Caco2 cell membrane after 2 hrs by LC-MS/MS analysis | 2011 | Bioorganic & medicinal chemistry, Apr-15, Volume: 19, Issue:8 | QSAR-based permeability model for drug-like compounds. |
| AID1491250 | Inhibition of CYP51 in Candida albicans ATCC SC5314 assessed as increase in eburicol content by GS-MS analysis | 2017 | European journal of medicinal chemistry, Sep-08, Volume: 137 | Design, synthesis and evaluation of aromatic heterocyclic derivatives as potent antifungal agents. |
| AID244861 | In-vitro minimum inhibitory concentration against the growth of Candida albicans | 2005 | Bioorganic & medicinal chemistry letters, Jul-01, Volume: 15, Issue:13 | Synthesis of (1,4)-naphthoquinono-[3,2-c]-1H-pyrazoles and their (1,4)-naphthohydroquinone derivatives as antifungal, antibacterial, and anticancer agents. |
| AID356359 | Antifungal activity against fluconazole-susceptible Candida albicans isolate 1 after 24 to 48 hrs by NCCLS method | 2003 | Journal of natural products, Aug, Volume: 66, Issue:8 | Acetylenic acids inhibiting azole-resistant Candida albicans from Pentagonia gigantifolia. |
| AID509282 | Permeability across BBMEC cocultured with rat C6 cell BBB model after 24 hrs in presence of 1 ug/ml Dexamethasone | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Effects of immunomodulatory and organism-associated molecules on the permeability of an in vitro blood-brain barrier model to amphotericin B and fluconazole. |
| AID375817 | Antifungal activity against Cryptococcus neoformans NCIM 576 by agar plate assay | 2009 | Bioorganic & medicinal chemistry letters, Jul-01, Volume: 19, Issue:13 | Synthesis of novel 3-(1-(1-substituted piperidin-4-yl)-1H-1,2,3-triazol-4-yl)-1,2,4-oxadiazol-5(4H)-one as antifungal agents. |
| AID547603 | Antifungal activity against Candida glabrata isolate Cg8R with CgPDR1 W297S | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | Microarray and molecular analyses of the azole resistance mechanism in Candida glabrata oropharyngeal isolates. |
| AID279709 | Antifungal activity against Candida albicans K1 biofilms in in-vivo rat catheter model in presence of beta 1,3-glucanase | 2007 | Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2 | Putative role of beta-1,3 glucans in Candida albicans biofilm resistance. |
| AID1279029 | Antifungal activity against Trichosporon asahii 1188 after 24 hrs by microbroth dilution method | 2016 | Bioorganic & medicinal chemistry, Mar-15, Volume: 24, Issue:6 | Salicylanilide N-monosubstituted carbamates: Synthesis and in vitro antimicrobial activity. |
| AID1430052 | Anti-fungal activity against Cryptococcus neoformans after 48 hrs by broth microdilution method | |||
| AID1905263 | Antifungal activity against fluconazole-resistant Candida albicans 311 assessed as inhibition of fungal growth by checker board microdilution assay | 2022 | Journal of medicinal chemistry, 04-14, Volume: 65, Issue:7 | Species-Selective Targeting of Fungal Hsp90: Design, Synthesis, and Evaluation of Novel 4,5-Diarylisoxazole Derivatives for the Combination Treatment of Azole-Resistant Candidiasis. |
| AID495359 | Antimicrobial activity against Candida albicans isolate SC5314 expressing UPC2 G648D/UPC2 G648D double mutant alleles by microdilution method relative wild type | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | An A643T mutation in the transcription factor Upc2p causes constitutive ERG11 upregulation and increased fluconazole resistance in Candida albicans. |
| AID1193504 | Antifungal activity against Candida albicans ATCC 18804 after 24 to 168 hrs by broth microdilution assay | 2015 | Bioorganic & medicinal chemistry, Apr-01, Volume: 23, Issue:7 | Synthesis and biological evaluation of fluconazole analogs with triazole-modified scaffold as potent antifungal agents. |
| AID554707 | Antimicrobial activity against Candida krusei NZCDC 89.021 after 48 hrs by liquid microdilution assay | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Abc1p is a multidrug efflux transporter that tips the balance in favor of innate azole resistance in Candida krusei. |
| AID582782 | Antifungal activity against Candida albicans isolate 488 harboring ERG3 H243N, T330A, A351V and ERG11 D225G, E266D, E391G, V488I mutant genes assessed as 14alpha-methylergosta-8,24(28)-dien-3beta,6alpha-diol content in total sterol composition at 0.5 time | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | Identification and characterization of four azole-resistant erg3 mutants of Candida albicans. |
| AID47220 | Antifungal activity against Candida albicans CY1002 | 2001 | Bioorganic & medicinal chemistry letters, Jul-23, Volume: 11, Issue:14 | Design and synthesis of novel benzofurans as a new class of antifungal agents targeting fungal N-myristoyltransferase. Part 1. |
| AID320384 | Antimicrobial activity against Candida albicans NCL1 by broth microdilution method | 2008 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 18, Issue:6 | Synthesis and antimicrobial activity of beta-lactam-bile acid conjugates linked via triazole. |
| AID1394704 | Antifungal activity against fluconazole-resistant Candida albicans ATCC 96901 after overnight incubation by CLSI broth microdilution method | 2018 | European journal of medicinal chemistry, Apr-25, Volume: 150 | Structure-activity relationship studies of ultra-short peptides with potent activities against fluconazole-resistant Candida albicans. |
| AID415950 | Antimicrobial activity against Cryptococcus neoformans by micro-broth dilution method | 2009 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 19, Issue:6 | Design, synthesis, and biological evaluation of novel 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-substituted benzylamino-2-propanols. |
| AID518170 | Antimicrobial activity against Cryptococcus gattii serotype C isolate H0058-1-1941 assessed as concentration required for heteroresistance | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Heteroresistance of Cryptococcus gattii to fluconazole. |
| AID419078 | Antifungal activity against Candida albicans ATCC 24433 | 2009 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 19, Issue:7 | Amide analogs of antifungal dioxane-triazole derivatives: synthesis and in vitro activities. |
| AID757551 | Anticandida activity against Candida albicans clinical isolate assessed as growth inhibition after 24 hrs by broth microdilution method | 2013 | European journal of medicinal chemistry, Jul, Volume: 65 | Synthesis and cytotoxicity of novel (thiazol-2-yl)hydrazine derivatives as promising anti-Candida agents. |
| AID405018 | Antifungal activity against Sporothrix schenckii P20825 isolate from cutaneous-lymphatic sporotrichosis patient after 72 hrs by modified NCCLS M38-A method | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | In vitro susceptibility of Sporothrix schenckii to six antifungal agents determined using three different methods. |
| AID301284 | Antifungal activity against Candida albicans after 48 hrs by broth micro dilution technique | 2007 | Bioorganic & medicinal chemistry, Nov-01, Volume: 15, Issue:21 | Synthesis of disulfide esters of dialkylaminocarbothioic acid as potent, non-detergent spermicidal agents. |
| AID666848 | Antifungal activity against Aspergillus flavus at 12.5 ug/ml after 72 hrs by well plate method | 2012 | European journal of medicinal chemistry, Aug, Volume: 54 | Synthesis, characterization and antimicrobial studies of some new quinoline incorporated benzimidazole derivatives. |
| AID1059360 | Fungicidal activity against Candida tropicalis by micro dilution method | 2013 | European journal of medicinal chemistry, , Volume: 70 | Designing and synthesis of novel antimicrobial heterocyclic analogs of fatty acids. |
| AID1770947 | Antifungal activity against fluconazole-sensitive Candida albicans 100 assessed as fungal growth inhibition by CLSI protocol based method | 2021 | European journal of medicinal chemistry, Dec-05, Volume: 225 | Design, synthesis and evaluation of novel 5-phenylthiophene derivatives as potent fungicidal of Candida albicans and antifungal reagents of fluconazole-resistant fungi. |
| AID572704 | Binding affinity to human CYP51 | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Identification, characterization, and azole-binding properties of Mycobacterium smegmatis CYP164A2, a homolog of ML2088, the sole cytochrome P450 gene of Mycobacterium leprae. |
| AID581891 | Antifungal activity against Candida albicans isolated from HSCT recipient 462 with acute or chronic GVHD mouth receiving antifungal drug after 112 days prophylaxis by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Impact of antifungal prophylaxis on colonization and azole susceptibility of Candida species. |
| AID584419 | Antifungal activity against 85 days cultured Candida glabrata isolated from HSCT recipient with acute or chronic GVHD mouth receiving antifungal therapy for 143 days after 116 days of prophylaxis by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Impact of antifungal prophylaxis on colonization and azole susceptibility of Candida species. |
| AID1157148 | Antifungal activity against Candida albicans ATCC 3153 after 48 hrs by CLSI broth microdilution method | 2014 | European journal of medicinal chemistry, Aug-18, Volume: 83 | Synthesis, biological evaluation and structure-activity correlation study of a series of imidazol-based compounds as Candida albicans inhibitors. |
| AID320387 | Antimicrobial activity against Yarrowia lipolytica NCL4 by broth microdilution method | 2008 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 18, Issue:6 | Synthesis and antimicrobial activity of beta-lactam-bile acid conjugates linked via triazole. |
| AID535688 | Antibacterial activity against Cryptococcus neoformans serotype AD after 72 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Antifungal susceptibilities among different serotypes of Cryptococcus gattii and Cryptococcus neoformans. |
| AID1527465 | Antifungal activity against Candida albicans NCIM-3102 at 18 to 24 hrs by CLSI based alamar blue assay | 2020 | European journal of medicinal chemistry, Jan-01, Volume: 185 | Structure-activity relationships (SAR) of triazine derivatives: Promising antimicrobial agents. |
| AID425155 | Antimicrobial activity against azole-resistant Candida albicans isolate CA10 assessed as log reduction in colony count at 10 ug/ml co-treated with calcineurin signaling inhibitor tacrolimus after 48 hrs by XTT assay | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | In vitro interactions between tacrolimus and azoles against Candida albicans determined by different methods. |
| AID293897 | Antifungal activity against Aspergillus sp. after 48 to 72 hrs by broth microdilution method | 2007 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 17, Issue:6 | Synthesis of pseudopeptides based L-tryptophan as a potential antimicrobial agent. |
| AID1157151 | Antifungal activity against Candida albicans ATCC 10261 after 48 hrs by CLSI broth microdilution method | 2014 | European journal of medicinal chemistry, Aug-18, Volume: 83 | Synthesis, biological evaluation and structure-activity correlation study of a series of imidazol-based compounds as Candida albicans inhibitors. |
| AID1419550 | Selectivity index, ratio of EC50 for toxicity in human BEAS2B cells to MIC50 for antifungal activity against ITC and FLC-resistant Candida albicans ATCC 1237 | 2017 | European journal of medicinal chemistry, Jun-16, Volume: 133 | Novel alkylated azoles as potent antifungals. |
| AID521524 | Antifungal activity against Candida albicans ATCC 96901 after 47 hrs by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | In vitro and in vivo antifungal activities of T-2307, a novel arylamidine. |
| AID1585629 | Antifungal activity against fluconazole-resistant Candida albicans isolate 17 cultured in YNB media after 24 hrs by broth microdilution method | 2019 | European journal of medicinal chemistry, Jan-15, Volume: 162 | Chemical preparation, biological evaluation and 3D-QSAR of ethoxysulfuron derivatives as novel antifungal agents targeting acetohydroxyacid synthase. |
| AID582246 | Antifungal activity against Candida krusei isolated from HSCT recipients with acute or chronic GVHD receiving fluconazole by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Impact of antifungal prophylaxis on colonization and azole susceptibility of Candida species. |
| AID365067 | Antifungal activity against Trichophyton rubrum FF5 after 5 days by broth macrodilution method | 2008 | Bioorganic & medicinal chemistry, Sep-01, Volume: 16, Issue:17 | Antifungal activity of synthetic di(hetero)arylamines based on the benzo[b]thiophene moiety. |
| AID1890298 | Antifungal activity against Mucor circinelloides M5 strain assessed as inhibition of fungal filamentation by measuring reduction in fungal hyphae growth at 25 ug/ml by microscopic analysis | 2022 | Bioorganic & medicinal chemistry letters, 05-01, Volume: 63 | Novel 2-aryl-4-aryloxyquinoline-based fungistatics for Mucor circinelloides. Biological evaluation of activity, QSAR and docking study. |
| AID582232 | Antifungal activity against Candida krusei isolated from neutropenic subjects with AML or MDS prior to initiation of posaconazole therapy by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Impact of antifungal prophylaxis on colonization and azole susceptibility of Candida species. |
| AID1742146 | Inhibition of CYP51 in Candida albicans ATCC SC5314 assessed as lanosterol level at 4 ug/ml incubated for 16 hrs by LC/MS analysis (Rvb = 6.62 %) | 2020 | European journal of medicinal chemistry, Nov-01, Volume: 205 | Design, synthesis and bioactivity evaluation of novel arylalkene-amide derivatives as dual-target antifungal inhibitors. |
| AID509288 | Permeability across BBMEC cocultured with rat C6 cell BBB model after 24 hrs in presence of 0.01 ug/ml TNF | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Effects of immunomodulatory and organism-associated molecules on the permeability of an in vitro blood-brain barrier model to amphotericin B and fluconazole. |
| AID644839 | Antifungal activity against Candida tropicalis DSM 11953 after 48 hrs by M27-A3 CLSI method | 2012 | European journal of medicinal chemistry, Mar, Volume: 49 | Synthesis and antifungal activity of a new series of 2-(1H-imidazol-1-yl)-1-phenylethanol derivatives. |
| AID369391 | Antimicrobial activity against Trichosporon asahii isolate | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | In vitro susceptibility to posaconazole of 1,903 yeast isolates recovered in France from 2003 to 2006 and tested by the method of the European committee on antimicrobial susceptibility testing. |
| AID245450 | Minimum inhibitory concentration against Candida tropicalis ATCC750 evaluated by in vitro agar diffusion and microbroth dilution assay | 2005 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 15, Issue:15 | Synthesis of some diguanidino 1-methyl-2,5-diaryl-1H-pyrroles as antifungal agents. |
| AID518408 | Antimicrobial activity against Cryptococcus gattii serotype B isolate B5788 assessed as heteroresistant isolates at 2 ug/ml | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Heteroresistance of Cryptococcus gattii to fluconazole. |
| AID547614 | Antifungal activity against Candida glabrata isolate Cg15S | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | Microarray and molecular analyses of the azole resistance mechanism in Candida glabrata oropharyngeal isolates. |
| AID613716 | Antifungal activity against Candida tropicalis ATCC 750 by broth dilution method | 2011 | Bioorganic & medicinal chemistry letters, Aug-15, Volume: 21, Issue:16 | Novel hybrids of fluconazole and furanones: design, synthesis and antifungal activity. |
| AID28681 | Partition coefficient (logD6.5) | 2000 | Journal of medicinal chemistry, Jun-29, Volume: 43, Issue:13 | QSAR model for drug human oral bioavailability. |
| AID407018 | Antimicrobial activity against Chk1 deficient Candida albicans CHK21 at planktonic cell density of 10'3 cells/ml after 48 hrs by XTT assay | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | Role for cell density in antifungal drug resistance in Candida albicans biofilms. |
| AID367160 | Antimicrobial activity against Trichophyton mentagrophytes by broth microdilution method | 2009 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 19, Issue:3 | Synthesis and antifungal activity of 1,2,3-triazole containing fluconazole analogues. |
| AID1138334 | Antimicrobial activity against fluconazole-resistant Candida albicans 103 after 24 hrs by serial dilution method | 2014 | Journal of medicinal chemistry, May-08, Volume: 57, Issue:9 | Design, synthesis, and structure-activity relationship studies of novel fused heterocycles-linked triazoles with good activity and water solubility. |
| AID1427210 | Antifungal activity against Trichophyton mentagrophytes 445 after 72 hrs by microdilution broth assay | 2017 | Bioorganic & medicinal chemistry, 03-15, Volume: 25, Issue:6 | Antimicrobial activity of rhodanine-3-acetic acid derivatives. |
| AID1918337 | Antifungal activity against fluconazole-resistant Candida albicans 17# assessed as inhibition of fungal growth measured after 72 hrs by CLSI based liquid medium dilution method | 2022 | Journal of medicinal chemistry, 11-10, Volume: 65, Issue:21 | Novel Aryl Alkamidazole Derivatives as Multifunctional Antifungal Inhibitors: Design, Synthesis, and Biological Evaluation. |
| AID1864892 | Antifungal activity against fluconazole -resistant Candida albicans CaR assessed as fungal growth inhibition measured after 72 hrs by double dilution method | |||
| AID751636 | Antifungal activity against Aspergillus flavus at 1000 ppm | 2013 | European journal of medicinal chemistry, Feb, Volume: 60 | Synthesis and antifungal activity of some s-mercaptotriazolobenzothiazolyl amino acid derivatives. |
| AID1529794 | Antifungal activity against Candida albicans ATCC 90028 after 18 to 20 hrs by broth microdilution assay | 2018 | European journal of medicinal chemistry, Dec-05, Volume: 160 | Norbornane-based cationic antimicrobial peptidomimetics targeting the bacterial membrane. |
| AID518139 | Antimicrobial activity against Cryptococcus gattii serotype B isolate RB-33 assessed as concentration required for heteroresistance | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Heteroresistance of Cryptococcus gattii to fluconazole. |
| AID1601670 | Antibiofilm activity against Candida albicans ATCC 10261 assessed as inhibition of biofilm formation by XTT reduction assay | |||
| AID45514 | Inhibitory effect on Candida albicans YEM27 quad deletion Strain | 2004 | Journal of medicinal chemistry, Jan-01, Volume: 47, Issue:1 | Folate-synthesizing enzyme system as target for development of inhibitors and inhibitor combinations against Candida albicans-synthesis and biological activity of new 2,4-diaminopyrimidines and 4'-substituted 4-aminodiphenyl sulfones. |
| AID544870 | Antimicrobial activity against mrr1-deficient Candida albicans by microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | Gain-of-function mutations in the transcription factor MRR1 are responsible for overexpression of the MDR1 efflux pump in fluconazole-resistant Candida dubliniensis strains. |
| AID1154850 | Antifungal activity against fluconazole-sensitive Candida albicans SC5314 assessed as change in ergosterol composition at 8 ug/ml after 24 hrs by GC-MS analysis (Rvb = 90%) | 2014 | ACS medicinal chemistry letters, May-08, Volume: 5, Issue:5 | Novel carboline derivatives as potent antifungal lead compounds: design, synthesis, and biological evaluation. |
| AID772331 | Antifungal activity against wild type Candida kefyr after 24 hrs by visually and spectrophotometric analysis | 2013 | ACS medicinal chemistry letters, Sep-12, Volume: 4, Issue:9 | Novel Macrocyclic Amidinoureas: Potent Non-Azole Antifungals Active against Wild-Type and Resistant Candida Species. |
| AID1864934 | Induction of mitochondrial membrane potential loss in Candida albicans ATCC SC5314 assessed as depolarized cells at 1 umol/ml incubated for 24 hrs by JC-1 staining based flow cytometry assay (Rvb = 0.76 to 3.29%) | |||
| AID584414 | Antifungal activity against 16 days cultured Candida glabrata isolated from HSCT recipient with acute or chronic GVHD mouth receiving antifungal therapy for 31 days after 28 days of prophylaxis by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Impact of antifungal prophylaxis on colonization and azole susceptibility of Candida species. |
| AID736605 | Antifungal activity against azole-resistant Candida albicans clinical isolate 7.O.A assessed as growth inhibition after 24 to 48 hrs by CLSI microbroth dilution method | 2013 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 23, Issue:6 | Synthesis and anti-Candida activity of novel 2-hydrazino-1,3-thiazole derivatives. |
| AID1295325 | Antifungal activity against Candida albicans after 48 hrs by broth microdilution method | 2016 | European journal of medicinal chemistry, Jun-10, Volume: 115 | Role of disulfide linkage in action of bis(dialkylaminethiocarbonyl)disulfides as potent double-Edged microbicidal spermicide: Design, synthesis and biology. |
| AID1918392 | Anti-inflammatory activity in mouse infected with Candida albicans assessed as reduction in PD-L1 expression in infection tissue at 20 mg/kg, ip administered on days 2,4,6,8,10,12 and measured on day 14 by western blot analysis | 2022 | Journal of medicinal chemistry, 11-10, Volume: 65, Issue:21 | Novel Aryl Alkamidazole Derivatives as Multifunctional Antifungal Inhibitors: Design, Synthesis, and Biological Evaluation. |
| AID406957 | Antifungal activity against fluconazole-resistant Candida albicans isolated from oropharyngeal or vaginal disease patient after 48 hrs by broth microdilution test | 2008 | Journal of medicinal chemistry, Jul-10, Volume: 51, Issue:13 | 1-[(3-Aryloxy-3-aryl)propyl]-1H-imidazoles, new imidazoles with potent activity against Candida albicans and dermatophytes. Synthesis, structure-activity relationship, and molecular modeling studies. |
| AID653255 | Antifungal activity against Candida krusei ATCC 6258 after 24 hrs by broth microdilution method | 2012 | Bioorganic & medicinal chemistry, Apr-15, Volume: 20, Issue:8 | Semisynthesis and antimicrobial activity of novel guttiferone-A derivatives. |
| AID405043 | Antifungal activity against Sporothrix schenckii P1621 isolate from cutaneous-lymphatic sporotrichosis patient after 72 hrs by Sensititre YeastOne method | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | In vitro susceptibility of Sporothrix schenckii to six antifungal agents determined using three different methods. |
| AID1898223 | Antifungal activity against Candida albicans 100 infected in ICR mouse assessed as delay in mortality at 0.25 mg/kg, po qd infected with fungus for 2 hrs prior to compound addition for 7 days and measured for 20 days | |||
| AID567434 | Antifungal activity against Saccharomyces cerevisiae after 48 hrs by Etest | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | In vitro antifungal activities of isavuconazole and comparators against rare yeast pathogens. |
| AID1419570 | Selectivity index, ratio of EC50 for toxicity in human BEAS2B cells to MIC50 for antifungal activity against Aspergillus flavus ATCC MYA-3631 | 2017 | European journal of medicinal chemistry, Jun-16, Volume: 133 | Novel alkylated azoles as potent antifungals. |
| AID1380518 | Antifungal activity against Candida albicans DSY294 assessed as inhibition of fungal growth incubated for 48 hrs by broth microdilution assay | 2018 | Bioorganic & medicinal chemistry letters, 06-01, Volume: 28, Issue:10 | Biofilm inhibition and anti-Candida activity of a cationic lipo-benzamide molecule with twin-nonyl chain. |
| AID1598052 | Antifungal activity against Candida albicans infected in Caenorhabditis elegans assessed as survival at 32 ug/ml relative to control | 2019 | European journal of medicinal chemistry, May-15, Volume: 170 | Current advances of triazole alcohols derived from fluconazole: Design, in vitro and in silico studies. |
| AID545190 | Antimicrobial activity against Candida albicans isolate S infected in NMRI mouse assessed as decrease in kidney bacterial burden at 50 mg/kg, ip measured on day 4 | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Breakthrough Aspergillus fumigatus and Candida albicans double infection during caspofungin treatment: laboratory characteristics and implication for susceptibility testing. |
| AID1465984 | Antifungal activity against Cryptococcus gattii NR-43209 after 68 hrs by broth dilution assay | 2017 | Bioorganic & medicinal chemistry, 06-01, Volume: 25, Issue:11 | Investigation of aryl isonitrile compounds with potent, broad-spectrum antifungal activity. |
| AID310268 | Antifungal activity against Candida tropicalis by serial dilution microplate method | 2007 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 17, Issue:23 | Rational design of N-alkyl derivatives of 2-amino-2-deoxy-d-glucitol-6P as antifungal agents. |
| AID521519 | Antifungal activity against Absidia corymbifera NBRC 4009 after 24 hrs by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | In vitro and in vivo antifungal activities of T-2307, a novel arylamidine. |
| AID1242644 | Antibacterial activity against methicillin/gentamicin-resistant Staphylococcus aureus ATCC 33592 after 16 hrs by microtiter broth dilution method | 2015 | ACS medicinal chemistry letters, Jul-09, Volume: 6, Issue:7 | Novel Chalcone-Thiazole Hybrids as Potent Inhibitors of Drug Resistant Staphylococcus aureus. |
| AID269983 | Antifungal activity against Candida glabrata 646 | 2006 | Journal of medicinal chemistry, Aug-10, Volume: 49, Issue:16 | Synthesis and antifungal activity of a novel series of alkyldimethylamine cyanoboranes and their derivatives. |
| AID1602364 | Antifungal activity against Candida glabrata 8535 after 48 hrs by spectrophotometery | 2019 | Journal of medicinal chemistry, 03-14, Volume: 62, Issue:5 | Discovery of Carboline Derivatives as Potent Antifungal Agents for the Treatment of Cryptococcal Meningitis. |
| AID47216 | Antifungal activity expressed as inhibitory concentration against Candida albicans CY1002 in YNBPB medium | 2002 | Bioorganic & medicinal chemistry letters, Feb-25, Volume: 12, Issue:4 | Design and synthesis of novel benzofurans as a new class of antifungal agents targeting fungal N-myristoyltransferase. Part 2. |
| AID766642 | Antifungal activity against Candida glabrata MTCC 3019 after 24 hrs by well diffusion method | 2013 | European journal of medicinal chemistry, Sep, Volume: 67 | Total synthesis and biological evaluation of clavaminol-G and its analogs. |
| AID563118 | Antifungal activity against Candida glabrata ATCC 90030 after 48 hrs by broth microdilution method in presence of 0.05% glucose | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | T-2307 shows efficacy in a murine model of Candida glabrata infection despite in vitro trailing growth phenomena. |
| AID737321 | Antimicrobial activity against Aspergillus terreus MTCC 1782 at 750 ug/ml after 72 hrs by cup plate method | 2013 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 23, Issue:7 | Synthesis of novel 2-amino-4-(5'-substituted 2'-phenyl-1H-indol-3'-yl)-6-aryl-4H-pyran-3-carbonitrile derivatives as antimicrobial and antioxidant agents. |
| AID1411879 | Inhibition of ergosterol biosynthesis in fluconazole resistant Candida albicans A171 at 8 ug/ml relative to control | 2017 | MedChemComm, Dec-01, Volume: 8, Issue:12 | Synergistic antifungal effect of cyclized chalcone derivatives and fluconazole against |
| AID302121 | Antifungal activity against Microsporum gypseum | 2007 | Journal of medicinal chemistry, Nov-01, Volume: 50, Issue:22 | Synthesis and antifungal activities of novel 2-aminotetralin derivatives. |
| AID544869 | Antimicrobial activity against wild-type Candida albicans SC5314 by microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | Gain-of-function mutations in the transcription factor MRR1 are responsible for overexpression of the MDR1 efflux pump in fluconazole-resistant Candida dubliniensis strains. |
| AID1235457 | Antifungal activity against Candida albicans ATCC 10261 after 48 hrs by disc diffusion assay | 2015 | Bioorganic & medicinal chemistry, Aug-01, Volume: 23, Issue:15 | Imidazole clubbed 1,3,4-oxadiazole derivatives as potential antifungal agents. |
| AID518182 | Antimicrobial activity against Cryptococcus gattii serotype B isolate NIH409 assessed as heteroresistant isolates at 2 ug/ml | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Heteroresistance of Cryptococcus gattii to fluconazole. |
| AID563116 | Antifungal activity against Candida glabrata ATCC 90030 after 48 hrs by broth microdilution method in presence of 0.2% glucose | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | T-2307 shows efficacy in a murine model of Candida glabrata infection despite in vitro trailing growth phenomena. |
| AID1707522 | Inhibition of biofilm formation in Candida albicans 0304103 at 2 to 32 ug/ml incubated for 24 hrs by XTT reduction assay | 2021 | Journal of medicinal chemistry, 01-28, Volume: 64, Issue:2 | Novel Carboline Fungal Histone Deacetylase (HDAC) Inhibitors for Combinational Treatment of Azole-Resistant Candidiasis. |
| AID1904391 | Ratio of MFC for fungicidal activity against Candida albicans CPCC400616 to MIC for antifungal activity against Candida albicans CPCC400616 | 2022 | European journal of medicinal chemistry, Apr-05, Volume: 233 | Design, synthesis, and evaluation of novel 3-thiophene derivatives as potent fungistatic and fungicidal reagents based on a conformational restriction strategy. |
| AID609889 | Antifungal activity against Candida albicans SC5314 by micro-broth dilution method | 2011 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 21, Issue:15 | Synthesis, in vitro evaluation and molecular docking studies of new triazole derivatives as antifungal agents. |
| AID1196799 | Antitrypanosomal activity against amastigote stage of Trypanosoma cruzi Tulahuen C4 infected in rat L6 cells assessed as parasite growth inhibition after 96 hrs by colorimetric analysis | 2015 | Journal of medicinal chemistry, Feb-12, Volume: 58, Issue:3 | Novel 3-nitrotriazole-based amides and carbinols as bifunctional antichagasic agents. |
| AID777340 | Antitubercular activity against Mycobacterium tuberculosis H37Rv assessed as growth inhibition after 24 hrs by agar microdilution method | 2013 | ACS medicinal chemistry letters, Oct-10, Volume: 4, Issue:10 | Identification of 1-[4-Benzyloxyphenyl)-but-3-enyl]-1H-azoles as New Class of Antitubercular and Antimicrobial Agents. |
| AID691699 | Antifungal activity against Cryptococcus gastricus MTCC 1715 after 24 hrs by serial dilution method | 2012 | Bioorganic & medicinal chemistry letters, Oct-15, Volume: 22, Issue:20 | Synthesis of β-ionone derived chalcones as potent antimicrobial agents. |
| AID1246677 | Antifungal activity against Cryptococcus neoformans F10 assessed as reduction in cell viability at 26 uM after 6 to 72 hrs by MTT assay | 2015 | European journal of medicinal chemistry, Sep-18, Volume: 102 | Thiazole compounds with activity against Cryptococcus gattii and Cryptococcus neoformans in vitro. |
| AID289665 | Antimicrobial activity against Aspergillus niger after 72 hrs by broth dilution assay | 2007 | Bioorganic & medicinal chemistry letters, Jan-15, Volume: 17, Issue:2 | N/C-4 substituted azetidin-2-ones: synthesis and preliminary evaluation as new class of antimicrobial agents. |
| AID1736720 | Antifungal activity against Candida albicans ATCC 102231 assessed as reduction in fungal growth incubated for 48 hrs by broth microdilution assay | 2020 | European journal of medicinal chemistry, Mar-15, Volume: 190 | 4-Substituted picolinohydrazonamides as a new class of potential antitubercular agents. |
| AID301287 | Antifungal activity against Candida albicans ATCC 10231 after 48 hrs by broth micro dilution technique | 2007 | Bioorganic & medicinal chemistry, Nov-01, Volume: 15, Issue:21 | Synthesis of disulfide esters of dialkylaminocarbothioic acid as potent, non-detergent spermicidal agents. |
| AID457985 | Antifungal activity against Candida krusei E28 after 24 hrs by microdilution method | 2010 | Bioorganic & medicinal chemistry, Mar-01, Volume: 18, Issue:5 | Antifungal 3,5-disubstituted furanones: From 5-acyloxymethyl to 5-alkylidene derivatives. |
| AID518691 | Antimicrobial activity against Cryptococcus gattii serotype B isolate NIH771 assessed as heteroresistant isolates at 16 ug/ml | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Heteroresistance of Cryptococcus gattii to fluconazole. |
| AID546077 | Antifungal activity against Candida pelliculosa isolated from candidemia patient by AFST-EUCAST microdilution method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | A 10-year survey of antifungal susceptibility of candidemia isolates from intensive care unit patients in Greece. |
| AID1063945 | Antifungal activity against Absidia corymbifera 272 after 48 hrs by broth microdilution method | 2014 | Bioorganic & medicinal chemistry, Jan-15, Volume: 22, Issue:2 | Salicylanilide diethyl phosphates: synthesis, antimicrobial activity and cytotoxicity. |
| AID395839 | Antimicrobial activity against Aspergillus fumigatus after 72 hrs by standard microbroth dilution assay | 2009 | European journal of medicinal chemistry, Jan, Volume: 44, Issue:1 | Tetrahydronaphthyl azole oxime ethers: the conformationally rigid analogues of oxiconazole as antibacterials. |
| AID1369478 | Antifungal activity against Candida albicans cgmcc 2.2086 in presence of KCl by broth dilution method | 2018 | Journal of medicinal chemistry, 05-10, Volume: 61, Issue:9 | Combating Drug-Resistant Fungi with Novel Imperfectly Amphipathic Palindromic Peptides. |
| AID581892 | Antifungal activity against Candida albicans isolated from HSCT recipient 042 with acute or chronic GVHD mouth after 112 days prophylaxis by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Impact of antifungal prophylaxis on colonization and azole susceptibility of Candida species. |
| AID1076259 | Antifungal activity against Candida albicans assessed as growth inhibition by NCCLS broth dilution assay | 2014 | European journal of medicinal chemistry, Mar-21, Volume: 75 | Synthesis, docking and evaluation of antioxidant and antimicrobial activities of novel 1,2,4-triazolo[3,4-b][1,3,4]thiadiazol-6-yl)selenopheno[2,3-d]pyrimidines. |
| AID1419494 | Antifungal activity against Candida albicans ATCC 64124 incubated for 48 hrs by modified CLSI M27-A3 protocol based method | 2017 | European journal of medicinal chemistry, Jun-16, Volume: 133 | Novel alkylated azoles as potent antifungals. |
| AID294566 | Antimicrobial activity against Candida albicans ATCC 90029 at 20 ug by disk diffusion method | 2007 | European journal of medicinal chemistry, Jun, Volume: 42, Issue:6 | Rapid synthesis of sulfone derivatives as potential anti-infectious agents. |
| AID625289 | Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for liver disease | 2011 | PLoS computational biology, Dec, Volume: 7, Issue:12 | Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). |
| AID521497 | Antifungal activity against Candida glabrata ATCC 90030 after 48 hrs by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | In vitro and in vivo antifungal activities of T-2307, a novel arylamidine. |
| AID1246766 | Cytotoxicity against C57BL/6 mouse peritoneal macrophages assessed as cell viability measured after 48 hrs by MTT assay | 2015 | European journal of medicinal chemistry, Sep-18, Volume: 102 | Thiazole compounds with activity against Cryptococcus gattii and Cryptococcus neoformans in vitro. |
| AID594999 | Antifungal activity against Candida albicans after 48 hrs | 2011 | Bioorganic & medicinal chemistry letters, May-15, Volume: 21, Issue:10 | Thermal solvent-free synthesis of novel pyrazolyl chalcones and pyrazolines as potential antimicrobial agents. |
| AID644846 | Antifungal activity against Candida krusei PMC 0613 after 48 hrs by M27-A3 CLSI method | 2012 | European journal of medicinal chemistry, Mar, Volume: 49 | Synthesis and antifungal activity of a new series of 2-(1H-imidazol-1-yl)-1-phenylethanol derivatives. |
| AID609981 | Antifungal activity against Penicillium notatum sp. at 1000 ug after 24 hrs by paper disc technique relative to control | 2011 | Bioorganic & medicinal chemistry letters, Aug-15, Volume: 21, Issue:16 | Efficient synthesis of antifungal active 9-substituted-3-aryl-5H,13aH-quinolino[3,2-f][1,2,4]triazolo[4,3-b][1,2,4]triazepines in ionic liquids. |
| AID1905280 | Antibiofilm activity against Candida albicans 904 assessed as inhibition of bacterial metabolism within the biofilm after 24 hrs by XTT reduction assay | 2022 | Journal of medicinal chemistry, 04-14, Volume: 65, Issue:7 | Species-Selective Targeting of Fungal Hsp90: Design, Synthesis, and Evaluation of Novel 4,5-Diarylisoxazole Derivatives for the Combination Treatment of Azole-Resistant Candidiasis. |
| AID718386 | Antimicrobial activity against Aspergillus niger NCIM 1196 by agar diffusion method | 2012 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 22, Issue:23 | POMA analyses as new efficient bioinformatics' platform to predict and optimise bioactivity of synthesized 3a,4-dihydro-3H-indeno[1,2-c]pyrazole-2-carboxamide/carbothioamide analogues. |
| AID719311 | Antimicrobial activity against Pseudomonas aeruginosa NCIM 5029 at 100 ug/mL incubated for 24 hrs by agar disc diffusion method | 2012 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 22, Issue:23 | Synthesis, characterization, antidepressant and antioxidant activity of novel piperamides bearing piperidine and piperazine analogues. |
| AID1609945 | Cytotoxicity against human A549 cells assessed as cell survival at 0.4 uM/l incubated for 24 hrs by MTT assay relative to control | |||
| AID1904386 | Antibiofilm activity against Candida albicans CPCC40061 assessed as inhibition of bacterial metabolism within the biofilm measured after 6 hrs by XTT reduction assay | 2022 | European journal of medicinal chemistry, Apr-05, Volume: 233 | Design, synthesis, and evaluation of novel 3-thiophene derivatives as potent fungistatic and fungicidal reagents based on a conformational restriction strategy. |
| AID725881 | Antifungal activity against Candida krusei CAKR8 after 24 hrs by spectrofluorometric analysis | 2013 | ACS medicinal chemistry letters, Feb-14, Volume: 4, Issue:2 | Discovery of a novel broad-spectrum antifungal agent derived from albaconazole. |
| AID1157181 | Antifungal activity against Candida albicans PMC 1041R after 48 hrs by CLSI broth microdilution method | 2014 | European journal of medicinal chemistry, Aug-18, Volume: 83 | Synthesis, biological evaluation and structure-activity correlation study of a series of imidazol-based compounds as Candida albicans inhibitors. |
| AID1918389 | Anti-inflammatory activity in mouse infected with Candida albicans assessed as reduction in IL-6R expression in spleen at 20 mg/kg, ip administered on days 2,4,6,8,10,12 and measured on day 14 by immunohistochemical analysis | 2022 | Journal of medicinal chemistry, 11-10, Volume: 65, Issue:21 | Novel Aryl Alkamidazole Derivatives as Multifunctional Antifungal Inhibitors: Design, Synthesis, and Biological Evaluation. |
| AID1076846 | Antifungal activity against planktonically grown Candida albicans ATCC 10231 by CLSI M27 A3 broth microdilution method | 2014 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 24, Issue:6 | Activity of caffeic acid derivatives against Candida albicans biofilm. |
| AID619598 | Antifungal activity against Candida guilliermondii after 24 hrs by broth microdilution method | 2011 | Bioorganic & medicinal chemistry, Oct-01, Volume: 19, Issue:19 | Antifungal activity of a series of 1,2-benzisothiazol-3(2H)-one derivatives. |
| AID1254319 | Antifungal activity against Candida krusei E28 after 48 hrs by microdilution broth method | 2015 | Bioorganic & medicinal chemistry, Nov-15, Volume: 23, Issue:22 | Novel derivatives of nitro-substituted salicylic acids: Synthesis, antimicrobial activity and cytotoxicity. |
| AID454199 | Antifungal activity against Cryptococcus neoformans NCIM 576 by standard agar plate method | 2010 | Bioorganic & medicinal chemistry letters, Jan-15, Volume: 20, Issue:2 | One pot synthesis and SAR of some novel 3-substituted 5,6-diphenyl-1,2,4-triazines as antifungal agents. |
| AID1864960 | Immunostimulatory activity in mouse infected with Candida albicans ATCC SC5314 assessed as reduction in PD-L1 expression in spleen in presence of naproxen by western blot analysis relative to control | |||
| AID747348 | Antibacterial activity against Eberthella typhosa by NCCLS method | 2013 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 23, Issue:11 | Synthesis and biological evaluation of a class of quinolone triazoles as potential antimicrobial agents and their interactions with calf thymus DNA. |
| AID1903350 | Antifungal activity against Aspergillus flavus ATCC 16870 assessed as reduction in fungal growth incubated for 24 hrs by two fold broth dilution method | 2022 | European journal of medicinal chemistry, Apr-05, Volume: 233 | Design, synthesis, and biological evaluation of novel spiro[pyrrolidine-2,3'-quinolin]-2'-one derivatives as potential chitin synthase inhibitors and antifungal agents. |
| AID285853 | Antimicrobial susceptibility of Pichia anomala from nosocomial fungemia patient assessed as percent susceptible isolates at 0.03 ug/ml by CLSI method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Antifungal drug susceptibility profile of Pichia anomala isolates from patients presenting with nosocomial fungemia. |
| AID50127 | Evaluation of In vitro antifungal activity against Candida guilliermondii 26 by broth macro dilution method | 1995 | Journal of medicinal chemistry, Sep-29, Volume: 38, Issue:20 | Synthesis and antifungal activity of new azole derivatives containing an N-acylmorpholine ring. |
| AID1302227 | Antifungal activity against fluconazole-susceptible Candida albicans ATCC 90028 in immunocompetent Balb/c mouse candidiasis model assessed as reduction in CFU count in kidney at 8 mg/kg/day, ip regime measured on day 7 post infection | 2016 | Journal of medicinal chemistry, 04-28, Volume: 59, Issue:8 | Biological Characterization and in Vivo Assessment of the Activity of a New Synthetic Macrocyclic Antifungal Compound. |
| AID486422 | Antibacterial activity against Trichoderma viride TT after 72 hrs by disc diffusion method | 2010 | European journal of medicinal chemistry, Jun, Volume: 45, Issue:6 | Synthesis and biological evaluation of beta-chloro vinyl chalcones as inhibitors of TNF-alpha and IL-6 with antimicrobial activity. |
| AID666846 | Antifungal activity against Aspergillus niger at 12.5 ug/ml after 72 hrs by well plate method | 2012 | European journal of medicinal chemistry, Aug, Volume: 54 | Synthesis, characterization and antimicrobial studies of some new quinoline incorporated benzimidazole derivatives. |
| AID582797 | Antifungal activity against Candida albicans isolate 14 by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | Identification and characterization of four azole-resistant erg3 mutants of Candida albicans. |
| AID738389 | Antifungal activity against Monilia albican ATCC 10231 after 24 to 72 hrs by NCCLS method | 2013 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 23, Issue:7 | Efficient synthesis and antimicrobial activity of some novel S-β-d-glucosides of 5-aryl-1,2,4-triazole-3-thiones derivatives. |
| AID1301344 | Inhibition of CYP2C9 (unknown origin) at 120 uM by P450-glo assay | 2016 | Bioorganic & medicinal chemistry, 07-01, Volume: 24, Issue:13 | Novel free fatty acid receptor 1 (GPR40) agonists based on 1,3,4-thiadiazole-2-carboxamide scaffold. |
| AID564273 | Antifungal activity against Candida albicans isolate 6 after 48 hrs by broth microdilution method in presence of 10 uM of efflux pump inhibitor FK506 | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | A clinical isolate of Candida albicans with mutations in ERG11 (encoding sterol 14alpha-demethylase) and ERG5 (encoding C22 desaturase) is cross resistant to azoles and amphotericin B. |
| AID1770936 | Anti-biofilm activity in Candida albicans CPCC400616 assessed as inhibition of biofilm formation incubated for 3 hrs by XTT assay | 2021 | European journal of medicinal chemistry, Dec-05, Volume: 225 | Design, synthesis and evaluation of novel 5-phenylthiophene derivatives as potent fungicidal of Candida albicans and antifungal reagents of fluconazole-resistant fungi. |
| AID665131 | Antifungal activity against 4 strains of Candida parapsilosis after 24 hrs by EUCAST broth microdilution method | 2012 | European journal of medicinal chemistry, Jul, Volume: 53 | Synthesis, anti-Candida activity, and cytotoxicity of new (4-(4-iodophenyl)thiazol-2-yl)hydrazine derivatives. |
| AID1905293 | Reversal of fluconazole mediated azole resistant Candida albicans 904 assessed as upregulation of CDR1 expression at 32 ug/ml by RT-PCR | 2022 | Journal of medicinal chemistry, 04-14, Volume: 65, Issue:7 | Species-Selective Targeting of Fungal Hsp90: Design, Synthesis, and Evaluation of Novel 4,5-Diarylisoxazole Derivatives for the Combination Treatment of Azole-Resistant Candidiasis. |
| AID365062 | Antifungal activity against Candida krusei ATCC 6258 after 48 hrs by broth macrodilution method | 2008 | Bioorganic & medicinal chemistry, Sep-01, Volume: 16, Issue:17 | Antifungal activity of synthetic di(hetero)arylamines based on the benzo[b]thiophene moiety. |
| AID1628387 | Antimicrobial activity against Bacillus subtilis ATCC 6633 incubated for 24 hrs by NCCLS protocol based method | 2016 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 26, Issue:12 | Discovery of novel berberine imidazoles as safe antimicrobial agents by down regulating ROS generation. |
| AID322375 | Binding affinity to human His-tagged CYP51 expressed in Escherichia coli | 2008 | Bioorganic & medicinal chemistry, Jan-01, Volume: 16, Issue:1 | Novel cholesterol biosynthesis inhibitors targeting human lanosterol 14alpha-demethylase (CYP51). |
| AID1634357 | Antifungal activity against Candida albicans ATCC SC5314 assessed as inhibition of visible microbe growth by broth microdilution method | 2019 | Bioorganic & medicinal chemistry letters, 09-01, Volume: 29, Issue:17 | Design, synthesis and evaluation of biphenyl imidazole analogues as potent antifungal agents. |
| AID395782 | Antifungal activity against biofilm-positive Candida albicans isolate after 48 hrs by twofold serial dilution technique | 2008 | European journal of medicinal chemistry, Nov, Volume: 43, Issue:11 | Synthesis, antimicrobial activity, pharmacophore analysis of some new 2-(substitutedphenyl/benzyl)-5-[(2-benzofuryl)carboxamido]benzoxazoles. |
| AID1592228 | Inhibition of SE/CYP51 in Candida albicans ATCC SC5314 assessed as effect on sterol composition by measuring ergosterol level at 16 ug/ml incubated for 90 mins by HPLC analysis (Rvb = 64.2%) | 2019 | Bioorganic & medicinal chemistry, 06-15, Volume: 27, Issue:12 | Design, synthesis and biological evaluation of amide-pyridine derivatives as novel dual-target (SE, CYP51) antifungal inhibitors. |
| AID1567576 | Antifungal activity against Candida albicans after 24 hrs by EUCAST method | 2019 | European journal of medicinal chemistry, Sep-15, Volume: 178 | Carvacrol prodrugs as novel antimicrobial agents. |
| AID50141 | Evaluation of In vitro antifungal activity against Candida krusei C64 by broth macro dilution method | 1995 | Journal of medicinal chemistry, Sep-29, Volume: 38, Issue:20 | Synthesis and antifungal activity of new azole derivatives containing an N-acylmorpholine ring. |
| AID1487479 | Antifungal activity against Aspergillus flavus assessed as zone of inhibition at 25 ug/ml measured after 24 hrs by well diffusion method | 2017 | Bioorganic & medicinal chemistry letters, 08-15, Volume: 27, Issue:16 | Synthesis, antioxidant, antifungal, molecular docking and ADMET studies of some thiazolyl hydrazones. |
| AID416850 | Antifungal activity against Trichophyton mentagrophytes DUMC160.03 by CLSI protocol | 2007 | Antimicrobial agents and chemotherapy, Oct, Volume: 51, Issue:10 | Targeting the calcineurin pathway enhances ergosterol biosynthesis inhibitors against Trichophyton mentagrophytes in vitro and in a human skin infection model. |
| AID551211 | Antifungal activity against Microsporum gypseum by broth microdilution method | 2011 | Bioorganic & medicinal chemistry letters, Jan-15, Volume: 21, Issue:2 | New azoles with antifungal activity: Design, synthesis, and molecular docking. |
| AID214294 | Inhibition of Trichophyton mentagrophytes 445 growth for 120 hours in vitro. | 2001 | Journal of medicinal chemistry, Aug-16, Volume: 44, Issue:17 | 3-Phenyl-5-acyloxymethyl-2H,5H-furan-2-ones: synthesis and biological activity of a novel group of potential antifungal drugs. |
| AID1287609 | Antifungal activity against Candida albicans clinical isolate after 18 to 24 hrs by micro-dilution method | 2016 | European journal of medicinal chemistry, May-04, Volume: 113 | Synthesis of newer 1,2,3-triazole linked chalcone and flavone hybrid compounds and evaluation of their antimicrobial and cytotoxic activities. |
| AID386935 | Antifungal activity against Candida albicans ATCC 66027 after 48 hrs by broth microdilution technique | 2008 | European journal of medicinal chemistry, Oct, Volume: 43, Issue:10 | Carbodithioic acid esters of fluoxetine, a novel class of dual-function spermicides. |
| AID704758 | Antifungal activity against Cryptococcus neoformans MY 2061 after 40 hrs by NCCLS broth microdilution method | 2012 | ACS medicinal chemistry letters, Oct-11, Volume: 3, Issue:10 | Antifungal spectrum, in vivo efficacy, and structure-activity relationship of ilicicolin h. |
| AID553846 | Antifungal activity against Saccharomyces cerevisiae ADMDR1 expressing Candida albicans MDR1 efflux pump in YNPG-proline medium after 24 hrs by microdilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | Enhanced susceptibility to antifungal oligopeptides in yeast strains overexpressing ABC multidrug efflux pumps. |
| AID531206 | Antifungal activity against Candida albicans ATCC 60193 after 48 hrs by CLSI method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Potent in vitro antifungal activities of naturally occurring acetylenic acids. |
| AID561436 | Antifungal activity against Candida lusitaniae CL174 by microdilution method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Nonsense and missense mutations in FCY2 and FCY1 genes are responsible for flucytosine resistance and flucytosine-fluconazole cross-resistance in clinical isolates of Candida lusitaniae. |
| AID1281696 | Antifungal activity against Candida utilis ATCC 9950 after 24 hrs by micro broth dilution method | 2016 | European journal of medicinal chemistry, Mar-23, Volume: 111 | Discovery of membrane active benzimidazole quinolones-based topoisomerase inhibitors as potential DNA-binding antimicrobial agents. |
| AID1451800 | Antifungal activity against Trichophyton verrucosum after 7 days | 2017 | Journal of medicinal chemistry, 10-12, Volume: 60, Issue:19 | Novel Inhibitors of Staphyloxanthin Virulence Factor in Comparison with Linezolid and Vancomycin versus Methicillin-Resistant, Linezolid-Resistant, and Vancomycin-Intermediate Staphylococcus aureus Infections in Vivo. |
| AID1517584 | Antifungal activity against Candida albicans ATCC 90028 assessed as growth inhibition incubated for 36 hrs by resazurin dye based assay | 2019 | European journal of medicinal chemistry, Dec-01, Volume: 183 | Exploration of the antibiotic potentiating activity of indolglyoxylpolyamines. |
| AID497799 | Antifungal activity against Candida glabrata by broth microdilution assay | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Assessment of the in vitro kinetic activity of caspofungin against Candida glabrata. |
| AID581864 | Antifungal activity against 29 days cultured Candida glabrata isolated from neutropenic subject with AML or MDS stool after 48 days of prophylaxis by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Impact of antifungal prophylaxis on colonization and azole susceptibility of Candida species. |
| AID642910 | Antifungal activity against Candida albicans ATCC 14053 | 2011 | ACS medicinal chemistry letters, May-12, Volume: 2, Issue:5 | Natural Product Based 6-Hydroxy-2,3,4,6-tetrahydropyrrolo[1,2-a]pyrimidinium Scaffold as A New Antifungal Template. |
| AID737320 | Antimicrobial activity against Aspergillus terreus MTCC 1782 at 500 ug/ml after 72 hrs by cup plate method | 2013 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 23, Issue:7 | Synthesis of novel 2-amino-4-(5'-substituted 2'-phenyl-1H-indol-3'-yl)-6-aryl-4H-pyran-3-carbonitrile derivatives as antimicrobial and antioxidant agents. |
| AID1478060 | Binding affinity to Mycobacterium tuberculosis CYP121A1 expressed in Escherichia coli TG1 (DE3) by UV-visible scanning spectrophotometric analysis | |||
| AID42882 | Inhibition of Candida lusitaniae 2446/I growth for 24 hours in vitro. | 2001 | Journal of medicinal chemistry, Aug-16, Volume: 44, Issue:17 | 3-Phenyl-5-acyloxymethyl-2H,5H-furan-2-ones: synthesis and biological activity of a novel group of potential antifungal drugs. |
| AID367158 | Antimicrobial activity against Cryptococcus neoformans by broth microdilution method | 2009 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 19, Issue:3 | Synthesis and antifungal activity of 1,2,3-triazole containing fluconazole analogues. |
| AID283224 | Prolongation of survival in CD1 mouse infected with Coccidioides immitis Silveira administered after 3 days of infection at 25 mg/kg, po bid after 12 days relative to control | 2007 | Antimicrobial agents and chemotherapy, Mar, Volume: 51, Issue:3 | Comparison of itraconazole and fluconazole treatments in a murine model of coccidioidal meningitis. |
| AID582806 | Antifungal activity against Candida albicans isolate 12 harboring ERG3 W332R mutant gene by broth microdilution method in presence of 10 uM drug efflux inhibitor FK506 | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | Identification and characterization of four azole-resistant erg3 mutants of Candida albicans. |
| AID1322105 | Antimicrobial activity against Candida tropicalis ATCC 13803 after 24 hrs by broth microdilution assay | 2016 | Bioorganic & medicinal chemistry, 11-01, Volume: 24, Issue:21 | Synthesis, characterization, and evaluation of (E)-methyl 2-((2-oxonaphthalen-1(2H)-ylidene)methylamino)acetate as a biological agent and an anion sensor. |
| AID480479 | Antifungal activity against Trichophyton rubrum after 7 days by serial dilution method | 2010 | Bioorganic & medicinal chemistry letters, May-01, Volume: 20, Issue:9 | Structure-based rational design, synthesis and antifungal activity of oxime-containing azole derivatives. |
| AID567445 | Antifungal activity against Trichosporon mucoides assessed as percent susceptible isolates after 48 hrs by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | In vitro antifungal activities of isavuconazole and comparators against rare yeast pathogens. |
| AID598225 | Antimicrobial activity against Candida albicans isolate 48 after 48 hrs by microdilution broth method | 2011 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 21, Issue:11 | Synthesis and in vitro antimicrobial activities of new (cyano-NNO-azoxy)pyrazole derivatives. |
| AID1156866 | Antimicrobial activity against Trichophyton mentagrophytes after 96 hrs by microbroth dilution method | 2014 | European journal of medicinal chemistry, Aug-18, Volume: 83 | Synthesis of 2,3,6-trideoxy sugar triazole hybrids as potential new broad spectrum antimicrobial agents. |
| AID1818281 | Induction of apoptosis against Candida albicans ATCC SC5314 assessed as mild apoptotic cells measured after 48 hrs by by Annexin V-FITC/propidium iodide staining based flow cytometry (Rvb =0.29 %) | |||
| AID424622 | Antimicrobial activity against azole-susceptible Candida albicans isolate CA129 after 48 hrs by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | In vitro interactions between tacrolimus and azoles against Candida albicans determined by different methods. |
| AID304971 | Antibacterial activity against Staphylococcus aureus by broth micro-dilution technique | 2007 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 17, Issue:1 | New antifungal flavonoid glycoside from Vitex negundo. |
| AID555575 | Antimicrobial activity against Candida famata by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Activity profile in vitro of micafungin against Spanish clinical isolates of common and emerging species of yeasts and molds. |
| AID1898169 | Antifungal activity against Candida tropicalis 112936 | |||
| AID424618 | Antimicrobial activity against azole-susceptible Candida albicans isolate CA5 after 48 hrs by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | In vitro interactions between tacrolimus and azoles against Candida albicans determined by different methods. |
| AID1456581 | Antifungal activity against Aspergillus fumigatus isolate 7544 by micro-broth dilution method | 2017 | Bioorganic & medicinal chemistry letters, 05-15, Volume: 27, Issue:10 | Design, synthesis, and in vitro evaluation of novel antifungal triazoles. |
| AID1609927 | Antifungal activity against Candida tropicalis GIM 2.183 assessed as reduction in fungal growth incubated for 24 hrs by serial dilution method | |||
| AID1904374 | Inhibition of CYP51 in Candida albicans ATCC SC5314 assessed as eburicol level at 0.25 ug/ml measured after 18 hrs by GC-MS analysis relative to control | 2022 | European journal of medicinal chemistry, Apr-05, Volume: 233 | Design, synthesis, and evaluation of novel 3-thiophene derivatives as potent fungistatic and fungicidal reagents based on a conformational restriction strategy. |
| AID575748 | Binding affinity to Aspergillus fumigatus AF293 sterol 14-alpha demethylase isoenzyme B expressed in Escherichia coli | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10 | Expression, purification, and characterization of Aspergillus fumigatus sterol 14-alpha demethylase (CYP51) isoenzymes A and B. |
| AID356365 | Antifungal activity against Candida albicans ATCC 90028 by sphingolipid reversal assay in presence of 1.25 ug/mL dihydrosphingosine | 2003 | Journal of natural products, Aug, Volume: 66, Issue:8 | Acetylenic acids inhibiting azole-resistant Candida albicans from Pentagonia gigantifolia. |
| AID518435 | Antimicrobial activity against Cryptococcus gattii serotype B isolate NIH444 assessed as heteroresistant isolates at 4 ug/ml | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Heteroresistance of Cryptococcus gattii to fluconazole. |
| AID1546088 | Antimicrobial activity against Pseudomonas aeruginosa | 2019 | European journal of medicinal chemistry, Dec-15, Volume: 184 | Current scenario of tetrazole hybrids for antibacterial activity. |
| AID457994 | Antifungal activity against Trichosporon beigelii 1188 after 48 hrs by microdilution method | 2010 | Bioorganic & medicinal chemistry, Mar-01, Volume: 18, Issue:5 | Antifungal 3,5-disubstituted furanones: From 5-acyloxymethyl to 5-alkylidene derivatives. |
| AID547563 | Antifungal activity against Candida albicans after 24 to 72 hrs by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | In vitro antifungal activities of bis(alkylpyridinium)alkane compounds against pathogenic yeasts and molds. |
| AID1550458 | Antifungal activity against Candida krusei ATCC 6258 assessed as decrease in fungal cell growth incubated for 24 hrs by E-test | 2019 | European journal of medicinal chemistry, Jun-01, Volume: 171 | Antimicrobial and KPC/AmpC inhibitory activity of functionalized benzosiloxaboroles. |
| AID1598021 | Antifungal activity against Aspergillus fumigatus after 24 hrs by microbroth dilution method | 2019 | European journal of medicinal chemistry, May-15, Volume: 170 | Current advances of triazole alcohols derived from fluconazole: Design, in vitro and in silico studies. |
| AID521985 | Antibacterial activity against Fluconazole resistant Candida albicans DSY3606 containing tac1delta/delta ERG11-1/ERG11-1 (TAC1-5) genotype infected in BALB/c mouse assessed as effect on infection outcome score administered intraperitoneally 1 hr post bact | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Genetic dissection of azole resistance mechanisms in Candida albicans and their validation in a mouse model of disseminated infection. |
| AID561435 | Antifungal activity against Candida lusitaniae CL128 by microdilution method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Nonsense and missense mutations in FCY2 and FCY1 genes are responsible for flucytosine resistance and flucytosine-fluconazole cross-resistance in clinical isolates of Candida lusitaniae. |
| AID531254 | Antifungal activity against Candida albicans assessed as susceptible dose-dependent isolates after 48 hrs by CLSI method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | In vitro susceptibilities of invasive isolates of Candida species: rapid increase in rates of fluconazole susceptible-dose dependent Candida glabrata isolates. |
| AID567436 | Antifungal activity against Trichosporon mucoides after 48 hrs by Etest | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | In vitro antifungal activities of isavuconazole and comparators against rare yeast pathogens. |
| AID1852892 | Antifungal activity against Candida auris clinical isolate assessed as inhibition of fungal growth incubated for 24 hrs by microdilution assay | 2022 | RSC medicinal chemistry, Nov-16, Volume: 13, Issue:11 | Efficient selective targeting of |
| AID520845 | Antifungal activity against Cryptococcus neoformans YC-11 by microdilution method | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | Efficacy of SPK-843, a novel polyene antifungal, in a murine model of systemic cryptococcosis. |
| AID525541 | Antimicrobial activity against Fonsecaea isolates after 72 hrs by CLSI M38-A2 protocol method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | In vitro activities of eight antifungal drugs against 55 clinical isolates of Fonsecaea spp. |
| AID582805 | Antifungal activity against Candida albicans isolate 177 by broth dilution method in presence of 10 uM drug efflux inhibitor FK506 | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | Identification and characterization of four azole-resistant erg3 mutants of Candida albicans. |
| AID279086 | Antimicrobial activity against Candida albicans at 24 hrs | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Association of fluconazole area under the concentration-time curve/MIC and dose/MIC ratios with mortality in nonneutropenic patients with candidemia. |
| AID525593 | Antibacterial activity against Fluconazole resistant Candida albicans DSY3604 containing tac1delta/delta ERG11-1/ERG11-5 genotype by EUCAST standards based broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Genetic dissection of azole resistance mechanisms in Candida albicans and their validation in a mouse model of disseminated infection. |
| AID319751 | Antimicrobial activity against Cryptococcus parapsilosis isolates | 2008 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 18, Issue:11 | Synthesis and SAR studies of biaryloxy-substituted triazoles as antifungal agents. |
| AID1175553 | Antimicrobial activity against Candida albicans ATCC 10231 after 18 hrs | 2015 | Journal of natural products, Jan-23, Volume: 78, Issue:1 | Antibacterial ilicicolinic acids C and D and ilicicolinal from Neonectria discophora SNB-CN63 isolated from a termite nest. |
| AID340963 | Antifungal activity against Cryptococcus neoformans ATCC 90112 by NCCLS M27-A2 method | 2007 | Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8 | Cross-resistance to medical and agricultural azole drugs in yeasts from the oropharynx of human immunodeficiency virus patients and from environmental Bavarian vine grapes. |
| AID285855 | Antimicrobial susceptibility of Pichia anomala from nosocomial fungemia patient assessed as percent susceptible isolates at 0.12 ug/ml by CLSI method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Antifungal drug susceptibility profile of Pichia anomala isolates from patients presenting with nosocomial fungemia. |
| AID50153 | Evaluation of In vitro antifungal activity against Candida krusei 70 by broth macro dilution method | 1995 | Journal of medicinal chemistry, Sep-29, Volume: 38, Issue:20 | Synthesis and antifungal activity of new azole derivatives containing an N-acylmorpholine ring. |
| AID420076 | Antifungal activity against Cryptococcus neoformans 6995 after 24 hrs by broth microdilution assay | 2009 | Bioorganic & medicinal chemistry, Jun-01, Volume: 17, Issue:11 | Bulky 1,4-benzoxazine derivatives with antifungal activity. |
| AID530929 | Antifungal activity against Fluconazole resistant Candida albicans isolate 17 at 163.3 uM after 48 hrs by CLSI method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Potent in vitro antifungal activities of naturally occurring acetylenic acids. |
| AID499658 | Metabolic stability in human liver microsomes | 2010 | Bioorganic & medicinal chemistry, Aug-15, Volume: 18, Issue:16 | Novel antifungal agents: triazolopyridines as inhibitors of beta-1,6-glucan synthesis. |
| AID609976 | Antifungal activity against Rhizopus sp. at 1000 ug after 24 hrs by paper disc technique | 2011 | Bioorganic & medicinal chemistry letters, Aug-15, Volume: 21, Issue:16 | Efficient synthesis of antifungal active 9-substituted-3-aryl-5H,13aH-quinolino[3,2-f][1,2,4]triazolo[4,3-b][1,2,4]triazepines in ionic liquids. |
| AID1877310 | Fungicidal activity against Candida albicans CPCC400616 assessed as minimum fungicidal concentration incubated for 48 hrs | 2022 | European journal of medicinal chemistry, Jan-05, Volume: 227 | Broadening antifungal spectrum and improving metabolic stablity based on a scaffold strategy: Design, synthesis, and evaluation of novel 4-phenyl-4,5-dihydrooxazole derivatives as potent fungistatic and fungicidal reagents. |
| AID642913 | Antifungal activity against amphotericin-B-resistant Candida albicans ATCC 200955 | 2011 | ACS medicinal chemistry letters, May-12, Volume: 2, Issue:5 | Natural Product Based 6-Hydroxy-2,3,4,6-tetrahydropyrrolo[1,2-a]pyrimidinium Scaffold as A New Antifungal Template. |
| AID1359819 | Antifungal activity against Candida albicans ATCC 76615 measured after 24 hrs | |||
| AID1593109 | Antimicrobial activity against Candida albicans ATCC 90028 incubated for 24 hrs by microdilution assay | 2019 | European journal of medicinal chemistry, Apr-15, Volume: 168 | Design, synthesis and biological evaluation of novel α-acyloxy carboxamides via Passerini reaction as caspase 3/7 activators. |
| AID608753 | Antifungal activity against Aspergillus flavus at 500 ug/ml after 72 hrs by agar diffusion method | 2011 | European journal of medicinal chemistry, Aug, Volume: 46, Issue:8 | Synthesis, characterization and antimicrobial studies of some new pyrazole incorporated imidazole derivatives. |
| AID745258 | Antimicrobial activity against Aspergillus niger clinical isolate after 18 to 24 hrs by micro-dilution method | 2013 | European journal of medicinal chemistry, May, Volume: 63 | Design, synthesis and antimicrobial activity of novel benzothiazole analogs. |
| AID1201583 | Antifungal activity against Aspergillus flavus at 0.5 mg/ml incubated for 3 days | 2015 | European journal of medicinal chemistry, May-05, Volume: 95 | Synthesis and biological evaluation of new imidazo[2,1-b][1,3,4]thiadiazole-benzimidazole derivatives. |
| AID1624192 | Antifungal activity against Cryptococcus neoformans NR-41299 after 24 hrs by microbroth dilution method | 2019 | Bioorganic & medicinal chemistry letters, 03-01, Volume: 29, Issue:5 | Benzimidazole tethered pyrrolo[3,4-b]quinoline with broad-spectrum activity against fungal pathogens. |
| AID519515 | Antifungal activity against Candida krusei isolates after 48 hrs by CLSI M27-A2 procedure based assay | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | In vitro antifungal activities of isavuconazole (BAL4815), voriconazole, and fluconazole against 1,007 isolates of zygomycete, Candida, Aspergillus, Fusarium, and Scedosporium species. |
| AID49810 | Fungicidal versus fungistatic activity of bifunctional sphingolipids against Candida glabrata at a concentration of 12 ug/mL before dilution replating; no growth in media | 2002 | Bioorganic & medicinal chemistry letters, Aug-19, Volume: 12, Issue:16 | Antifungal activity of bifunctional sphingolipids. Intramolecular synergism within long-chain alpha,omega-bis-aminoalcohols. |
| AID1584747 | Drug metabolism in dog liver microsome S9 fraction assessed as CYP450-mediated metabolism by measuring compound remaining at 5 uM pretreated with NADPH and measured after 30 mins by UPLC-MS/MS analysis | 2018 | Journal of medicinal chemistry, 10-25, Volume: 61, Issue:20 | Discovery of Novel 7-Aryl 7-Deazapurine 3'-Deoxy-ribofuranosyl Nucleosides with Potent Activity against Trypanosoma cruzi. |
| AID377834 | Antifungal activity against Candida albicans ATCC 14503 | 2005 | Journal of natural products, Apr, Volume: 68, Issue:4 | Majusculoic acid, a brominated cyclopropyl fatty acid from a marine cyanobacterial mat assemblage. |
| AID531540 | Antifungal activity against Candida glabrata clinical isolate overexpressing CDR1 gene obtained from cervicovaginal candidiasis patient assessed as resistant isolates by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Antifungal resistance of Candida glabrata vaginal isolates and development of a quantitative reverse transcription-PCR-based azole susceptibility assay. |
| AID1334857 | Inhibition of Candida albicans SC5314 CYP51 assessed as eburicol composition of total sterols at 8 ug/ml by GC-MS method relative to control | 2017 | Bioorganic & medicinal chemistry, 01-15, Volume: 25, Issue:2 | Discovery of biphenyl imidazole derivatives as potent antifungal agents: Design, synthesis, and structure-activity relationship studies. |
| AID1809928 | Induction of drug resistant in Candida albicans ATCC SC5314 assessed as increase in FCZ IC50 at 16 times IC50 | 2021 | Journal of medicinal chemistry, 11-11, Volume: 64, Issue:21 | Optimization and Evaluation of Novel Antifungal Agents for the Treatment of Fungal Infection. |
| AID674388 | Antifungal activity against Candida albicans MTCC 2827 at 1 mg/ml after 72 hrs by well plate method | 2012 | Bioorganic & medicinal chemistry letters, Jul-15, Volume: 22, Issue:14 | Synthesis of benzofuran based 1,3,5-substituted pyrazole derivatives: as a new class of potent antioxidants and antimicrobials--a novel accost to amend biocompatibility. |
| AID118064 | In vivo evaluation of % survival rate after peroral administration on 7th day at dose 1 mg/kg | 1995 | Journal of medicinal chemistry, Sep-29, Volume: 38, Issue:20 | Synthesis and antifungal activity of new azole derivatives containing an N-acylmorpholine ring. |
| AID405096 | Antimicrobial activity against Mucor sp. after 24 hrs | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | In vitro susceptibilities of 217 clinical isolates of zygomycetes to conventional and new antifungal agents. |
| AID405186 | Antimicrobial activity against Blastoschizomyces capitatus IHEM 5666 isolate by microdilution method | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | Combined therapies in a murine model of blastoschizomycosis. |
| AID424645 | Antimicrobial activity against azole-resistant Candida albicans isolate CA10 assessed as growth at 16 ug/ml cotreated with 0.125 ug/ml calcineurin signaling inhibitor tacrolimus after 48 hrs by microdilution checkerboard technique relative to control | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | In vitro interactions between tacrolimus and azoles against Candida albicans determined by different methods. |
| AID405097 | Antimicrobial activity against Absidia sp. after 24 hrs | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | In vitro susceptibilities of 217 clinical isolates of zygomycetes to conventional and new antifungal agents. |
| AID220225 | The compound was tested in vitro for antifungal activity against 10 yeasts. | 1998 | Journal of medicinal chemistry, May-21, Volume: 41, Issue:11 | New azole antifungals. 2. Synthesis and antifungal activity of heterocyclecarboxamide derivatives of 3-amino-2-aryl-1-azolyl-2-butanol. |
| AID1689209 | Antifungal activity against Candida albicans SS5314 assessed as reduction in fungal growth by CLSI based broth microdilution method | 2020 | European journal of medicinal chemistry, Mar-01, Volume: 189 | Oxadiazolylthiazoles as novel and selective antifungal agents. |
| AID518158 | Antimicrobial activity against Cryptococcus gattii serotype C isolate NIH312 assessed as concentration required for heteroresistance | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Heteroresistance of Cryptococcus gattii to fluconazole. |
| AID567440 | Antifungal activity against Trichosporon jirovecii after 48 hrs by Etest | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | In vitro antifungal activities of isavuconazole and comparators against rare yeast pathogens. |
| AID424628 | Antimicrobial activity against azole-susceptible Candida albicans isolate CA5 co-treated with calcineurin signaling inhibitor tacrolimus after 48 hrs by microdilution checkerboard technique | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | In vitro interactions between tacrolimus and azoles against Candida albicans determined by different methods. |
| AID509278 | Permeability across BBMEC cocultured with rat C6 cell BBB model after 24 hrs in presence of 1 ug/ml lipopolysaccharide | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Effects of immunomodulatory and organism-associated molecules on the permeability of an in vitro blood-brain barrier model to amphotericin B and fluconazole. |
| AID582227 | Antifungal activity against Candida albicans isolated from HSCT recipients with acute or chronic GVHD receiving fluconazole by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Impact of antifungal prophylaxis on colonization and azole susceptibility of Candida species. |
| AID530941 | Antifungal activity against Trichophyton rubrum ATCC 10218 by CLSI method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Potent in vitro antifungal activities of naturally occurring acetylenic acids. |
| AID1783106 | Antifungal activity against fluconazole-resistant Candida tropicalis 5008 assessed as inhibition of cell proliferation at 32 ug/ml measured for 48 hrs by time growth curve assay | 2021 | European journal of medicinal chemistry, Oct-05, Volume: 221 | Lanosterol 14α-demethylase (CYP51)/histone deacetylase (HDAC) dual inhibitors for treatment of Candida tropicalis and Cryptococcus neoformans infections. |
| AID569367 | Antifungal activity against Rhizopus species at 500 ug after 24 hrs by paper disc technique | 2011 | European journal of medicinal chemistry, Feb, Volume: 46, Issue:2 | Efficient and novel one-pot synthesis of antifungal active 1-substituted-8-aryl-3-alkyl/aryl-4H-pyrazolo[4,5-f][1,2,4]triazolo[4,3-b][1,2,4]triazepines using solid support. |
| AID1254068 | Antibacterial activity against Staphylococcus aureus 209 after 24 hrs by two-fold serial dilution method | 2015 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 25, Issue:22 | Synthesis and biological evaluation of 1,3-diaryl pyrazole derivatives as potential antibacterial and anti-inflammatory agents. |
| AID285864 | Antimicrobial susceptibility of Pichia anomala from nosocomial fungemia patient assessed as percent susceptible isolates at 0.03 ug/ml by EUCAST method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Antifungal drug susceptibility profile of Pichia anomala isolates from patients presenting with nosocomial fungemia. |
| AID457991 | Antifungal activity against Candida lusitaniae 2446/I after 24 hrs by microdilution method | 2010 | Bioorganic & medicinal chemistry, Mar-01, Volume: 18, Issue:5 | Antifungal 3,5-disubstituted furanones: From 5-acyloxymethyl to 5-alkylidene derivatives. |
| AID440308 | Anticandidal activity against Candida albicans ATCC 60193 after 24 hrs by spectrophotometry | 2009 | Journal of medicinal chemistry, Dec-10, Volume: 52, Issue:23 | Synthesis of new linear guanidines and macrocyclic amidinourea derivatives endowed with high antifungal activity against Candida spp. and Aspergillus spp. |
| AID1585631 | Antifungal activity against fluconazole-resistant Candida albicans isolate 17 cultured in YNB media after 72 hrs by broth microdilution method | 2019 | European journal of medicinal chemistry, Jan-15, Volume: 162 | Chemical preparation, biological evaluation and 3D-QSAR of ethoxysulfuron derivatives as novel antifungal agents targeting acetohydroxyacid synthase. |
| AID1405037 | Antifungal activity against Candida tropicalis after 24 hrs by two-fold broth microdilution assay | 2018 | European journal of medicinal chemistry, Jul-15, Volume: 155 | Novel carbazole-triazole conjugates as DNA-targeting membrane active potentiators against clinical isolated fungi. |
| AID420070 | Antifungal activity against Candida krusei after 24 hrs by broth microdilution assay | 2009 | Bioorganic & medicinal chemistry, Jun-01, Volume: 17, Issue:11 | Bulky 1,4-benzoxazine derivatives with antifungal activity. |
| AID531462 | Antifungal activity against Candida glabrata assessed as susceptible dose-dependent isolates after 48 hrs by CLSI method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | In vitro susceptibilities of invasive isolates of Candida species: rapid increase in rates of fluconazole susceptible-dose dependent Candida glabrata isolates. |
| AID582220 | Antifungal activity against Candida krusei isolated from HSCT recipients with acute or chronic GVHD prior to initiation of posaconazole therapy by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Impact of antifungal prophylaxis on colonization and azole susceptibility of Candida species. |
| AID582792 | Antifungal activity against Candida albicans isolate 177 assessed as eburicol content in total sterol composition at 0.5 times MIC by GC-MS analysis | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | Identification and characterization of four azole-resistant erg3 mutants of Candida albicans. |
| AID642900 | Antifungal activity against amphotericin-B-resistant Candida albicans ATCC 200955 at 160 ug/ml | 2011 | ACS medicinal chemistry letters, May-12, Volume: 2, Issue:5 | Natural Product Based 6-Hydroxy-2,3,4,6-tetrahydropyrrolo[1,2-a]pyrimidinium Scaffold as A New Antifungal Template. |
| AID405071 | Antifungal activity against Candida parapsilosis ATCC 22019 isolate from cutaneous-lymphatic sporotrichosis patient after 72 hrs by ATB Fungus 2 method | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | In vitro susceptibility of Sporothrix schenckii to six antifungal agents determined using three different methods. |
| AID424655 | Antimicrobial activity against azole-resistant Candida albicans isolate CA10 assessed as growth at 8 ug/ml cotreated with 0.063 ug/ml calcineurin signaling inhibitor tacrolimus after 48 hrs by microdilution checkerboard technique relative to control | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | In vitro interactions between tacrolimus and azoles against Candida albicans determined by different methods. |
| AID766651 | Antifungal activity against Candida albicans MTCC 183 after 24 hrs by well diffusion method | 2013 | European journal of medicinal chemistry, Sep, Volume: 67 | Total synthesis and biological evaluation of clavaminol-G and its analogs. |
| AID1180301 | Antimicrobial activity against Aspergillus flavus NCIM-539 after 20 hrs by two fold serial macrodilution technique | 2014 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 24, Issue:15 | One pot three components microwave assisted and conventional synthesis of new 3-(4-chloro-2-hydroxyphenyl)-2-(substituted) thiazolidin-4-one as antimicrobial agents. |
| AID406950 | Antifungal activity against Candida parapsilosis ATCC 22019 at 35 degC after 48 hrs by broth microdilution test | 2008 | Journal of medicinal chemistry, Jul-10, Volume: 51, Issue:13 | 1-[(3-Aryloxy-3-aryl)propyl]-1H-imidazoles, new imidazoles with potent activity against Candida albicans and dermatophytes. Synthesis, structure-activity relationship, and molecular modeling studies. |
| AID518411 | Antimicrobial activity against Cryptococcus gattii serotype B isolate VPB572-058 assessed as heteroresistant isolates at 2 ug/ml | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Heteroresistance of Cryptococcus gattii to fluconazole. |
| AID547613 | Antifungal activity against Candida glabrata isolate Cg14R with CgPDR1 N764I mutant | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | Microarray and molecular analyses of the azole resistance mechanism in Candida glabrata oropharyngeal isolates. |
| AID1886110 | Hemolytic activity in rabbit RBC at 256 ug/ml incubated for 1 hr by spectrophotometry | |||
| AID46928 | Antifungal activity against Candida albicans at an intraperitoneal dose of 20 mg/kg twice a day for 6 days in mice in experiment 1 | 2004 | Bioorganic & medicinal chemistry letters, Mar-08, Volume: 14, Issue:5 | Approaches towards the stabilization of hemiaminal function at ornithine unit of mulundocandin. |
| AID1063952 | Antifungal activity against Candida krusei E28 after 24 hrs by broth microdilution method | 2014 | Bioorganic & medicinal chemistry, Jan-15, Volume: 22, Issue:2 | Salicylanilide diethyl phosphates: synthesis, antimicrobial activity and cytotoxicity. |
| AID1758042 | Inhibition of CYP51 in Candida albicans ATCC SC5314 assessed as Eburicol level at 0.125 ug/ml after 16 hrs by GC-MS analysis (Rvb = 0%) | 2021 | European journal of medicinal chemistry, Apr-15, Volume: 216 | Lead optimization generates selenium-containing miconazole CYP51 inhibitors with improved pharmacological profile for the treatment of fungal infections. |
| AID521516 | Antifungal activity against Fusarium solani IFO 31093 after 48 hrs by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | In vitro and in vivo antifungal activities of T-2307, a novel arylamidine. |
| AID678722 | Covalent binding affinity to human liver microsomes assessed per mg of protein at 10 uM after 60 mins presence of NADPH | 2012 | Chemical research in toxicology, Oct-15, Volume: 25, Issue:10 | Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds. |
| AID405044 | Antifungal activity against Sporothrix schenckii P1621 isolate from cutaneous-lymphatic sporotrichosis patient after 72 hrs by ATB Fungus 2 method | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | In vitro susceptibility of Sporothrix schenckii to six antifungal agents determined using three different methods. |
| AID598890 | Fungicidal activity against Candida albicans SC5314 assessed as biofilm eradication after 24 hrs | 2011 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 21, Issue:12 | Novel fungicidal benzylsulfanyl-phenylguanidines. |
| AID1254324 | Antifungal activity against Aspergillus fumigatus 231 after 24 hrs by microdilution broth method | 2015 | Bioorganic & medicinal chemistry, Nov-15, Volume: 23, Issue:22 | Novel derivatives of nitro-substituted salicylic acids: Synthesis, antimicrobial activity and cytotoxicity. |
| AID1138354 | Antimicrobial activity against fluconazole-resistant Candida albicans 103 infected in ICR mouse assessed as mean survival days at 0.5 mg/kg, po qd for 5 days starting 2 hrs post infection (Rvb = 1.5 +/- 0.53 days) | 2014 | Journal of medicinal chemistry, May-08, Volume: 57, Issue:9 | Design, synthesis, and structure-activity relationship studies of novel fused heterocycles-linked triazoles with good activity and water solubility. |
| AID530937 | Antifungal activity against Candida krusei ATCC 6258 at 163.3 uM after 48 hrs by CLSI method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Potent in vitro antifungal activities of naturally occurring acetylenic acids. |
| AID1904287 | Inhibition of Cryptococcus neoformans H99 delta5,6-desaturase assessed as upregulation of ERG3 gene expression at 2 ug/ml incubated for 24 hrs by RT-PCR analysis | 2022 | Journal of medicinal chemistry, 05-12, Volume: 65, Issue:9 | Discovery of Novel Sertraline Derivatives as Potent Anti- |
| AID1435667 | Antifungal activity against Absidia corymbifera 272 after 24 hrs by broth microdilution method | 2017 | European journal of medicinal chemistry, Jan-27, Volume: 126 | S-substituted 3,5-dinitrophenyl 1,3,4-oxadiazole-2-thiols and tetrazole-5-thiols as highly efficient antitubercular agents. |
| AID1546136 | Antimicrobial activity against Shigella dysenteriae after 24 hrs by two-fold broth serial dilution method | 2019 | European journal of medicinal chemistry, Dec-15, Volume: 184 | Current scenario of tetrazole hybrids for antibacterial activity. |
| AID1877282 | Antifungal activity against Cryptococcus neoformans CGMCC 2.3161 assessed as fungal growth inhibition by NCCLS protocol based method | 2022 | European journal of medicinal chemistry, Jan-05, Volume: 227 | Broadening antifungal spectrum and improving metabolic stablity based on a scaffold strategy: Design, synthesis, and evaluation of novel 4-phenyl-4,5-dihydrooxazole derivatives as potent fungistatic and fungicidal reagents. |
| AID1818277 | Antifungal activity against Candida albicans strain 901 assessed as reduction in fungal growth incubated for 72 hrs by CLSI protocol based broth microdilution method | |||
| AID28235 | Unbound fraction (plasma) | 2002 | Journal of medicinal chemistry, Jun-20, Volume: 45, Issue:13 | Prediction of volume of distribution values in humans for neutral and basic drugs using physicochemical measurements and plasma protein binding data. |
| AID521531 | Antifungal activity against Candida glabrata clinical isolates after 48 hrs by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | In vitro and in vivo antifungal activities of T-2307, a novel arylamidine. |
| AID1055722 | Antifungal activity against Saccharomyces cerevisiae after 24 to 48 hrs by agar well diffusion method | 2013 | European journal of medicinal chemistry, , Volume: 70 | Solution-phase microwave assisted parallel synthesis of N,N'-disubstituted thioureas derived from benzoic acid: biological evaluation and molecular docking studies. |
| AID1877315 | Cytotoxicity against human A549 cells assessed as inhibition of cell growth incubated for 4 hrs by MTT assay | 2022 | European journal of medicinal chemistry, Jan-05, Volume: 227 | Broadening antifungal spectrum and improving metabolic stablity based on a scaffold strategy: Design, synthesis, and evaluation of novel 4-phenyl-4,5-dihydrooxazole derivatives as potent fungistatic and fungicidal reagents. |
| AID405098 | Antimicrobial activity against Mucor circinelloides after 24 hrs | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | In vitro susceptibilities of 217 clinical isolates of zygomycetes to conventional and new antifungal agents. |
| AID310267 | Antifungal activity against Candida glabrata by serial dilution microplate method | 2007 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 17, Issue:23 | Rational design of N-alkyl derivatives of 2-amino-2-deoxy-d-glucitol-6P as antifungal agents. |
| AID598228 | Antimicrobial activity against Candida krusei isolate 48 after 48 hrs by microdilution broth method | 2011 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 21, Issue:11 | Synthesis and in vitro antimicrobial activities of new (cyano-NNO-azoxy)pyrazole derivatives. |
| AID309845 | Antifungal activity against Candida albicans after 2 days by twofold serial dilution method | 2007 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 17, Issue:21 | Quantitative structure-activity relationship studies for prediction of antimicrobial activity of synthesized 2,4-hexadienoic acid derivatives. |
| AID717774 | Antimicrobial activity against Aspergillus fumigatus 231 after 48 hrs by broth microdilution test | 2012 | Bioorganic & medicinal chemistry, Dec-15, Volume: 20, Issue:24 | Contribution to investigation of antimicrobial activity of styrylquinolines. |
| AID1138337 | Antimicrobial activity against fluconazole-resistant Candida albicans J38 after 24 hrs by serial dilution method | 2014 | Journal of medicinal chemistry, May-08, Volume: 57, Issue:9 | Design, synthesis, and structure-activity relationship studies of novel fused heterocycles-linked triazoles with good activity and water solubility. |
| AID1556218 | Inhibition of CYP51 in Candida albicans ATCC SC5314 assessed as ergosterol level at 8 ug/ml incubated for 16 hrs by GC/MS analysis (Rvb = 100%) | 2019 | European journal of medicinal chemistry, Sep-01, Volume: 177 | Design, synthesis, and structure-activity relationship studies of l-amino alcohol derivatives as broad-spectrum antifungal agents. |
| AID588214 | FDA HLAED, liver enzyme composite activity | 2004 | Current drug discovery technologies, Dec, Volume: 1, Issue:4 | Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling. |
| AID1465968 | Antifungal activity against Candida albicans NR-29448 after 44 hrs by broth dilution assay | 2017 | Bioorganic & medicinal chemistry, 06-01, Volume: 25, Issue:11 | Investigation of aryl isonitrile compounds with potent, broad-spectrum antifungal activity. |
| AID205796 | Fungicidal concentration on sterol 14-alpha-demethylase | 2003 | Journal of medicinal chemistry, Oct-09, Volume: 46, Issue:21 | Identification and prediction of promiscuous aggregating inhibitors among known drugs. |
| AID563127 | Antifungal activity against Candida glabrata ATCC 90030 after 24 hrs by Almar blue assay in presence of 0.2% glucosel | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | T-2307 shows efficacy in a murine model of Candida glabrata infection despite in vitro trailing growth phenomena. |
| AID521492 | Antifungal activity against Candida albicans ATCC 10261 after 48 hrs by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | In vitro and in vivo antifungal activities of T-2307, a novel arylamidine. |
| AID588217 | FDA HLAED, serum glutamic pyruvic transaminase (SGPT) increase | 2004 | Current drug discovery technologies, Dec, Volume: 1, Issue:4 | Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling. |
| AID425159 | Antifungal activity against Candida parapsilosis ATCC 22019 after 48 hrs by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | Posaconazole activity against Candida glabrata after exposure to caspofungin or amphotericin B. |
| AID1330186 | Antibacterial activity against Staphylococcus aureus 4220 measured after 24 hrs by two-fold serial dilution method | 2016 | Bioorganic & medicinal chemistry letters, 12-15, Volume: 26, Issue:24 | Synthesis and biological evaluation of chalcone derivatives containing aminoguanidine or acylhydrazone moieties. |
| AID1628385 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus N315 incubated for 24 hrs by NCCLS protocol based method | 2016 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 26, Issue:12 | Discovery of novel berberine imidazoles as safe antimicrobial agents by down regulating ROS generation. |
| AID1272748 | Antifungal activity against Aspergillus niger at 0.06 mol/L after 2 to 4 days by paper disc method | 2016 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 26, Issue:3 | Synthesis, antimicrobial activity of Schiff base compounds of cinnamaldehyde and amino acids. |
| AID1369453 | Antifungal activity against Candida tropicalis cgmcc 2.1975 after 48 hrs by broth microdilution method | 2018 | Journal of medicinal chemistry, 05-10, Volume: 61, Issue:9 | Combating Drug-Resistant Fungi with Novel Imperfectly Amphipathic Palindromic Peptides. |
| AID1595051 | Antifungal activity against Candida albicans V-01-191A-261 assessed as reduction in fungal cell growth incubated for 48 hrs by broth microdilution method | 2019 | European journal of medicinal chemistry, May-15, Volume: 170 | Tetrazole hybrids and their antifungal activities. |
| AID555566 | Antimicrobial activity against Candida albicans by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Activity profile in vitro of micafungin against Spanish clinical isolates of common and emerging species of yeasts and molds. |
| AID1472816 | Antifungal activity against itraconazole and fluconazole resistant Candida albicans ATCC 90819 after 48 hrs by broth dilution method | 2018 | Journal of medicinal chemistry, 01-11, Volume: 61, Issue:1 | Alkylated Piperazines and Piperazine-Azole Hybrids as Antifungal Agents. |
| AID598294 | Antimicrobial activity against Candida glabrata isolate 46 after 48 hrs by microdilution broth method | 2011 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 21, Issue:11 | Synthesis and in vitro antimicrobial activities of new (cyano-NNO-azoxy)pyrazole derivatives. |
| AID619085 | Antifungal activity against Candida parapsilosis 22019 by broth dilution method | 2011 | Journal of medicinal chemistry, Oct-13, Volume: 54, Issue:19 | High-throughput-screening-based identification and structure-activity relationship characterization defined (S)-2-(1-aminoisobutyl)-1-(3-chlorobenzyl)benzimidazole as a highly antimycotic agent nontoxic to cell lines. |
| AID532955 | Antifungal activity against Candida albicans isolate V5 with CAI genotype by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | Correlation between azole susceptibilities, genotypes, and ERG11 mutations in Candida albicans isolates associated with vulvovaginal candidiasis in China. |
| AID776457 | Antimicrobial activity against Candida albicans ATCC 60193 at 5 ug | 2013 | European journal of medicinal chemistry, Nov, Volume: 69 | Design, synthesis and biological activities of some 7-aminocephalosporanic acid derivatives. |
| AID1783091 | Downregulation of MDR1 mRNA expression in Candida tropicalis 5008 at 4 ug/ml measured after 24 hrs by qRT-PCR analysis | 2021 | European journal of medicinal chemistry, Oct-05, Volume: 221 | Lanosterol 14α-demethylase (CYP51)/histone deacetylase (HDAC) dual inhibitors for treatment of Candida tropicalis and Cryptococcus neoformans infections. |
| AID1624191 | Antifungal activity against Cryptococcus neoformans NR-41298 after 24 hrs by microbroth dilution method | 2019 | Bioorganic & medicinal chemistry letters, 03-01, Volume: 29, Issue:5 | Benzimidazole tethered pyrrolo[3,4-b]quinoline with broad-spectrum activity against fungal pathogens. |
| AID1759470 | Antifungal activity against Cryptococcus neoformans PFCC 93-589 in presence of Aureobasidin-A by checkerboard microtiter assay | 2021 | Bioorganic & medicinal chemistry letters, 06-01, Volume: 41 | Inhibitory effects and mechanism of antifungal action of the natural cyclic depsipeptide, aureobasidin A against Cryptococcus neoformans. |
| AID1491257 | Inhibition of CYP51 in Candida albicans ATCC SC5314 assessed as obtusifoliol content at 0.125 ug/ml by GS-MS analysis relative to total sterols (Rvb = 0.6%) | 2017 | European journal of medicinal chemistry, Sep-08, Volume: 137 | Design, synthesis and evaluation of aromatic heterocyclic derivatives as potent antifungal agents. |
| AID1634152 | Lipophilicity, log D of compound at pH 7.4 | 2019 | Bioorganic & medicinal chemistry letters, 08-15, Volume: 29, Issue:16 | Strategies for the development of highly selective cytochrome P450 inhibitors: Several CYP targets in current research. |
| AID555594 | Antimicrobial activity against Trichosporon dermatis by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Activity profile in vitro of micafungin against Spanish clinical isolates of common and emerging species of yeasts and molds. |
| AID568491 | Antifungal activity against Saccharomyces cerevisiae ATCC 9763 by twofold broth dilution method | 2011 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 21, Issue:3 | Synthesis and evaluation of a class of new coumarin triazole derivatives as potential antimicrobial agents. |
| AID1738703 | Antifungal activity against Cryptococcus neoformans CGMCC2.3161 measured after 72 hrs by micro-broth dilution assay | 2020 | European journal of medicinal chemistry, Jul-15, Volume: 198 | Design, synthesis, and biological evaluation of novel miconazole analogues containing selenium as potent antifungal agents. |
| AID50129 | Evaluation of In vitro antifungal activity against Candida guilliermondii 26 by broth macro dilution method | 1995 | Journal of medicinal chemistry, Sep-29, Volume: 38, Issue:20 | Synthesis and antifungal activity of new azole derivatives containing an N-acylmorpholine ring. |
| AID1254322 | Antifungal activity against Trichosporon asahii 1188 after 24 hrs by microdilution broth method | 2015 | Bioorganic & medicinal chemistry, Nov-15, Volume: 23, Issue:22 | Novel derivatives of nitro-substituted salicylic acids: Synthesis, antimicrobial activity and cytotoxicity. |
| AID555582 | Antimicrobial activity against Candida orthopsilosis by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Activity profile in vitro of micafungin against Spanish clinical isolates of common and emerging species of yeasts and molds. |
| AID666851 | Antifungal activity against Aspergillus terreus at 6.25 ug/ml after 72 hrs by well plate method | 2012 | European journal of medicinal chemistry, Aug, Volume: 54 | Synthesis, characterization and antimicrobial studies of some new quinoline incorporated benzimidazole derivatives. |
| AID405015 | Antifungal activity against Sporothrix schenckii P25013 isolate from cutaneous-lymphatic sporotrichosis patient after 72 hrs by modified NCCLS M38-A method | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | In vitro susceptibility of Sporothrix schenckii to six antifungal agents determined using three different methods. |
| AID352585 | Antimicrobial activity against Candida tropicalis ATCC 13803 at 5 ug after 18 hrs by agar-well diffusion method | 2009 | European journal of medicinal chemistry, Mar, Volume: 44, Issue:3 | Synthesis of some new 1,2,4-triazoles, their Mannich and Schiff bases and evaluation of their antimicrobial activities. |
| AID619180 | Antifungal activity against Candida albicans AN 1699 by broth dilution method | 2011 | Journal of medicinal chemistry, Oct-13, Volume: 54, Issue:19 | High-throughput-screening-based identification and structure-activity relationship characterization defined (S)-2-(1-aminoisobutyl)-1-(3-chlorobenzyl)benzimidazole as a highly antimycotic agent nontoxic to cell lines. |
| AID754921 | Antifungal activity against Candida krusei E28 assessed as growth inhibition after 24 to 48 hrs by microbroth dilution method | 2013 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 23, Issue:12 | Synthesis and antimycobacterial evaluation of N-substituted 5-chloropyrazine-2-carboxamides. |
| AID1859332 | Antimicrobial activity against Candida auris 919 | 2022 | Journal of medicinal chemistry, 02-24, Volume: 65, Issue:4 | Application of the All-Hydrocarbon Stapling Technique in the Design of Membrane-Active Peptides. |
| AID625285 | Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for hepatic necrosis | 2011 | PLoS computational biology, Dec, Volume: 7, Issue:12 | Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). |
| AID655725 | Antifungal activity against Trichoderma viride MTCC 1107 after 48 hrs poison food method | 2012 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 22, Issue:8 | Design, synthesis, synergistic antimicrobial activity and cytotoxicity of 4-aryl substituted 3,4-dihydropyrimidinones of curcumin. |
| AID307397 | Antifungal activity against Candida lusitaniae ATCC 42720 by broth microdilution assay | 2007 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 17, Issue:12 | Discovery of novel indazole-linked triazoles as antifungal agents. |
| AID542083 | Antifungal activity against Candida albicans ATCC 24433 after 24 hrs by microdilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Discovery of a small-molecule inhibitor of {beta}-1,6-glucan synthesis. |
| AID1380522 | Antifungal activity against Candida parapsilosis MTCC 7043 assessed as inhibition of fungal growth incubated for 48 hrs by broth microdilution assay | 2018 | Bioorganic & medicinal chemistry letters, 06-01, Volume: 28, Issue:10 | Biofilm inhibition and anti-Candida activity of a cationic lipo-benzamide molecule with twin-nonyl chain. |
| AID1783812 | Inhibition of Candida albicans CYP51 assessed as 14alpha-methylergosta-8,24(28)-dien3beta-6alpha-diol level at 0.25 ug/ml measured after 18 hrs by GC-MS analysis relative to control | 2021 | European journal of medicinal chemistry, Nov-15, Volume: 224 | Improving the metabolic stability of antifungal compounds based on a scaffold hopping strategy: Design, synthesis, and structure-activity relationship studies of dihydrooxazole derivatives. |
| AID208063 | In vitro antifungal activity against Trichophyton mentagrophytes CM84 | 2002 | Journal of medicinal chemistry, Oct-24, Volume: 45, Issue:22 | Synthesis, antifungal activity, and molecular modeling studies of new inverted oxime ethers of oxiconazole. |
| AID493524 | Antifungal activity against Absidia corymbifera 272 after 48 hrs by broth microdilution assay | 2010 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 20, Issue:15 | N-Benzylsalicylthioamides as novel compounds with promising antimycotic activity. |
| AID283846 | Antifungal activity against Candida albicans NCIM no. 300 after 3 to 4 days by serial plate dilution method | 2007 | European journal of medicinal chemistry, Jan, Volume: 42, Issue:1 | Synthesis and antimicrobial studies on novel chloro-fluorine containing hydroxy pyrazolines. |
| AID565402 | Antifungal activity against Rhizopus microsporus IHEM 10123 by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Correlation of in vitro activity, serum levels, and in vivo efficacy of posaconazole against Rhizopus microsporus in a murine disseminated infection. |
| AID1628392 | Antimicrobial activity against Candida albicans ATCC 76615 incubated for 24 hrs by NCCLS protocol based method | 2016 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 26, Issue:12 | Discovery of novel berberine imidazoles as safe antimicrobial agents by down regulating ROS generation. |
| AID1904365 | Antifungal activity against FLC-resistant Candida albicans CaR assessed as fungal growth inhibition by CLSI based serial microbroth dilution method | 2022 | European journal of medicinal chemistry, Apr-05, Volume: 233 | Design, synthesis, and evaluation of novel 3-thiophene derivatives as potent fungistatic and fungicidal reagents based on a conformational restriction strategy. |
| AID1602377 | Antibiofilm activity against Cryptococcus neoformans H99 assessed as inhibition of cellular surface hydrophobicity at 10 ug/ml incubated for 24 hrs by water-hydrocarbon two-phase assay | 2019 | Journal of medicinal chemistry, 03-14, Volume: 62, Issue:5 | Discovery of Carboline Derivatives as Potent Antifungal Agents for the Treatment of Cryptococcal Meningitis. |
| AID777329 | Antifungal activity against Aspergillus fumigatus isolated from patient assessed as growth inhibition after 72 to 96 hrs by microbroth dilution method | 2013 | ACS medicinal chemistry letters, Oct-10, Volume: 4, Issue:10 | Identification of 1-[4-Benzyloxyphenyl)-but-3-enyl]-1H-azoles as New Class of Antitubercular and Antimicrobial Agents. |
| AID655581 | Antifungal activity against Candida albicans Y0109 after 24 hrs by microbroth dilution method | 2012 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 22, Issue:8 | New triazole derivatives as antifungal agents: synthesis via click reaction, in vitro evaluation and molecular docking studies. |
| AID457988 | Antifungal activity against Candida tropicalis 156 after 48 hrs by microdilution method | 2010 | Bioorganic & medicinal chemistry, Mar-01, Volume: 18, Issue:5 | Antifungal 3,5-disubstituted furanones: From 5-acyloxymethyl to 5-alkylidene derivatives. |
| AID1903358 | Antifungal activity against fluconazole resistant Aspergillus flavus ATCC 16870 assessed as reduction in fungal growth incubated for 24 hrs by two fold broth dilution method | 2022 | European journal of medicinal chemistry, Apr-05, Volume: 233 | Design, synthesis, and biological evaluation of novel spiro[pyrrolidine-2,3'-quinolin]-2'-one derivatives as potential chitin synthase inhibitors and antifungal agents. |
| AID1602401 | Antifungal activity against Cryptococcus neoformans H99 assessed as up-regulation of Cdc25C expression at 2 to 4 ug/ml after 24 hrs by Western blot analysis | 2019 | Journal of medicinal chemistry, 03-14, Volume: 62, Issue:5 | Discovery of Carboline Derivatives as Potent Antifungal Agents for the Treatment of Cryptococcal Meningitis. |
| AID278385 | Antifungal activity against Candida lusitaniae 6936 revertant fcy1delta::[FCY1-URA3] by microdilution assay | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Molecular mechanism of flucytosine resistance in Candida lusitaniae: contribution of the FCY2, FCY1, and FUR1 genes to 5-fluorouracil and fluconazole cross-resistance. |
| AID405022 | Antifungal activity against Sporothrix schenckii P30019 isolate from cutaneous-lymphatic sporotrichosis patient after 72 hrs by Sensititre YeastOne method | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | In vitro susceptibility of Sporothrix schenckii to six antifungal agents determined using three different methods. |
| AID406955 | Therapeutic index, ratio of CC50 for human U937 cells to MIC90 for Candida albicans ATCC 10261 | 2008 | Journal of medicinal chemistry, Jul-10, Volume: 51, Issue:13 | 1-[(3-Aryloxy-3-aryl)propyl]-1H-imidazoles, new imidazoles with potent activity against Candida albicans and dermatophytes. Synthesis, structure-activity relationship, and molecular modeling studies. |
| AID293380 | Antifungal activity against Cryptococcus neoformans after 72 hrs by micro-broth dilution method | 2007 | European journal of medicinal chemistry, Aug, Volume: 42, Issue:8 | Synthesis and evaluation of novel 1-(1H-1,2,4-triazol-1-yl)-2-(2,4-difluorophenyl)-3-[(4-substitutedphenyl)-piperazin-1-yl]-propan-2-ols as antifungal agents. |
| AID561419 | Antifungal activity against fcy1-deficient Candida lusitaniae by microdilution method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Nonsense and missense mutations in FCY2 and FCY1 genes are responsible for flucytosine resistance and flucytosine-fluconazole cross-resistance in clinical isolates of Candida lusitaniae. |
| AID1610303 | Antifungal activity against Candida albicans CPCC400616 measured at 24 hrs by CLSI protocol based microbroth dilution method | 2019 | Bioorganic & medicinal chemistry letters, 12-01, Volume: 29, Issue:23 | Design, synthesis and biological evaluation of novel semicarbazone-selenochroman-4-ones hybrids as potent antifungal agents. |
| AID486966 | Antifungal activity against Trichophyton mentagrophytes after 96 hrs by micro broth dilution method | 2010 | European journal of medicinal chemistry, Jun, Volume: 45, Issue:6 | 'On water' assisted synthesis and biological evaluation of nitrogen and sulfur containing hetero-1,4-naphthoquinones as potent antifungal and antibacterial agents. |
| AID1904262 | Antifungal activity against Candida krusei 10153 assessed as inhibition of fungal growth incubated for 48 hrs by microdilution method | 2022 | Journal of medicinal chemistry, 05-12, Volume: 65, Issue:9 | Discovery of Novel Sertraline Derivatives as Potent Anti- |
| AID1320751 | Fungicidal activity against Candida albicans ATCC 90028 after 48 hrs by broth microdilution method | 2016 | Bioorganic & medicinal chemistry, 11-15, Volume: 24, Issue:22 | Synthesis of novel tetrazole derivatives and evaluation of their antifungal activity. |
| AID428906 | Reduction in LAC1 gene expression in Cryptococcus neoformans ATCC 24067 at 0.25 to 0.5 times MIC after 7 days by qRT-PCR relative to control | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Voriconazole inhibits melanization in Cryptococcus neoformans. |
| AID555600 | Antimicrobial activity against Trichosporon domesticum by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Activity profile in vitro of micafungin against Spanish clinical isolates of common and emerging species of yeasts and molds. |
| AID459753 | Antifungal activity against Candida albicans by serial dilution method | 2010 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 20, Issue:3 | Synthesis and antifungal activities in vitro of novel pyrazino [2,1-a] isoquinolin derivatives. |
| AID519683 | Antimicrobial activity against Saccharomyces cerevisiae containing disruption in YLR456W gene by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Genomewide screening for genes associated with gliotoxin resistance and sensitivity in Saccharomyces cerevisiae. |
| AID521976 | Antibacterial activity against Fluconazole resistant Candida albicans DSY296 overexpressing multidrug transporter gene CDR1 and CDR2 and containing ERG11 G464S mutation containing CIp10 to restore URA3 function infected in BALB/c mouse assessed as weight | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Genetic dissection of azole resistance mechanisms in Candida albicans and their validation in a mouse model of disseminated infection. |
| AID642931 | Antifungal activity against Trichophyton rubrum ATCC 10218 | 2011 | ACS medicinal chemistry letters, May-12, Volume: 2, Issue:5 | Natural Product Based 6-Hydroxy-2,3,4,6-tetrahydropyrrolo[1,2-a]pyrimidinium Scaffold as A New Antifungal Template. |
| AID287827 | Antifungal activity against Trichosporon beigelii 1188 after 24 hrs | 2007 | Bioorganic & medicinal chemistry, Apr-15, Volume: 15, Issue:8 | Hybrid molecules of estrone: new compounds with potential antibacterial, antifungal, and antiproliferative activities. |
| AID1864883 | Antifungal activity against Aspergillus fumigatus KM8001 assessed as fungal growth inhibition measured after 72 hrs in presence of naproxen by double dilution method | |||
| AID567860 | Antifungal activity against Penicillium citrinum NCIM 768 after 72 hrs | 2011 | European journal of medicinal chemistry, Feb, Volume: 46, Issue:2 | Synthesis, antidepressant and antifungal evaluation of novel 2-chloro-8-methylquinoline amine derivatives. |
| AID1918334 | Antifungal activity against Candida krusei ATCC 6258 assessed as inhibition of fungal growth measured after 72 hrs by CLSI based liquid medium dilution method | 2022 | Journal of medicinal chemistry, 11-10, Volume: 65, Issue:21 | Novel Aryl Alkamidazole Derivatives as Multifunctional Antifungal Inhibitors: Design, Synthesis, and Biological Evaluation. |
| AID49988 | Tested in vitro for the minimum inhibitory concentration (MIC) against Candida glabrata ATCC 90030 | 2002 | Bioorganic & medicinal chemistry letters, Mar-11, Volume: 12, Issue:5 | Synthesis of Sordaricin analogues as potent antifungal agents against Candida albicans. |
| AID47219 | Antifungal activity expressed as inhibitory concentration against Candida albicans in calf serum | 2002 | Bioorganic & medicinal chemistry letters, Feb-25, Volume: 12, Issue:4 | Design and synthesis of novel benzofurans as a new class of antifungal agents targeting fungal N-myristoyltransferase. Part 2. |
| AID1759063 | Antifungal activity against Aspergillus niger | 2021 | Bioorganic & medicinal chemistry letters, 06-01, Volume: 41 | Microwave assisted regioselective synthesis of quinoline appended triazoles as potent anti-tubercular and antifungal agents via copper (I) catalyzed cycloaddition. |
| AID432800 | Antifungal activity against Sporothrix schenckii after 72 hrs by microdilution method | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | In vitro antifungal susceptibilities of five species of sporothrix. |
| AID531234 | Antifungal activity against Candida albicans after 48 hrs by CLSI method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | In vitro susceptibilities of invasive isolates of Candida species: rapid increase in rates of fluconazole susceptible-dose dependent Candida glabrata isolates. |
| AID594937 | Antimicrobial activity against Candida albicans after 24 hrs by NCCLS method | 2011 | European journal of medicinal chemistry, May, Volume: 46, Issue:5 | Design and synthesis of antifungal benzoheterocyclic derivatives by scaffold hopping. |
| AID1565875 | Antifungal activity against Candida albicans ATCC 76615 assessed as growth inhibition measured after 24 hrs by two-fold broth dilution method | 2019 | European journal of medicinal chemistry, Nov-15, Volume: 182 | Design, synthesis and biological evaluation of novel diazaspiro[4.5]decan-1-one derivatives as potential chitin synthase inhibitors and antifungal agents. |
| AID372238 | Effect on CDR2 RNA level in Candida albicans CHK21 at MIC after 120 mins by RT-PCR | 2007 | Antimicrobial agents and chemotherapy, Oct, Volume: 51, Issue:10 | The Ssk1p response regulator and Chk1p histidine kinase mutants of Candida albicans are hypersensitive to fluconazole and voriconazole. |
| AID598230 | Antimicrobial activity against Candida tropicalis isolate 11 after 48 hrs by microdilution broth method | 2011 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 21, Issue:11 | Synthesis and in vitro antimicrobial activities of new (cyano-NNO-azoxy)pyrazole derivatives. |
| AID274920 | Antifungal activity against Aspergillus fumigatus ATCC 90906 | 2006 | Journal of medicinal chemistry, Dec-28, Volume: 49, Issue:26 | Synthesis, antifungal activity, and structure-activity relationships of coruscanone A analogues. |
| AID1474168 | Antifungal activity against Candida albicans ATCC SC5314 by broth microdilution assay | 2016 | European journal of medicinal chemistry, Nov-10, Volume: 123 | Design, synthesis, and structure-activity relationship studies of benzothiazole derivatives as antifungal agents. |
| AID1405039 | Antifungal activity against Candida albicans ATCC 90023 after 24 hrs by two-fold broth microdilution assay | 2018 | European journal of medicinal chemistry, Jul-15, Volume: 155 | Novel carbazole-triazole conjugates as DNA-targeting membrane active potentiators against clinical isolated fungi. |
| AID1695837 | Antifungal activity against Aspergillus brasiliensis MTCC 1344 incubated for 7 days by microdilution method | 2019 | European journal of medicinal chemistry, Apr-15, Volume: 168 | Comprehensive review on the anti-bacterial activity of 1,2,3-triazole hybrids. |
| AID367166 | Cytotoxicity against human Hep3B cells at 1 mg/ml | 2009 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 19, Issue:3 | Synthesis and antifungal activity of 1,2,3-triazole containing fluconazole analogues. |
| AID774836 | Antifungal activity against Chrysosporium keratinophilum at 0.5 to 1 mg/ml at 25 degC after 3 days by well plate method | 2013 | European journal of medicinal chemistry, Oct, Volume: 68 | Synthesis, characterization and molecular docking studies of some new 1,3,4-oxadiazolines bearing 6-methylpyridine moiety for antimicrobial property. |
| AID300441 | Antifungal activity against Candida krusei ATCC 6258 after 48 hrs by broth microdilution test | 2007 | Bioorganic & medicinal chemistry, Sep-01, Volume: 15, Issue:17 | 1-Acylthiosemicarbazides, 1,2,4-triazole-5(4H)-thiones, 1,3,4-thiadiazoles and hydrazones containing 5-methyl-2-benzoxazolinones: synthesis, analgesic-anti-inflammatory and antimicrobial activities. |
| AID745595 | Antifungal activity against Candida parapsilosis ATCC 22019 assessed as growth inhibition after 18 hrs by CLSI microdilution method | 2013 | Journal of natural products, May-24, Volume: 76, Issue:5 | Antifungal agents from Pseudallescheria boydii SNB-CN73 isolated from a Nasutitermes sp. termite. |
| AID405064 | Antifungal activity against Sporothrix schenckii P3287 isolate from cutaneous-lymphatic sporotrichosis patient after 72 hrs by Sensititre YeastOne method | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | In vitro susceptibility of Sporothrix schenckii to six antifungal agents determined using three different methods. |
| AID1465970 | Antifungal activity against Candida albicans ATCC 29351 after 44 hrs by broth dilution assay | 2017 | Bioorganic & medicinal chemistry, 06-01, Volume: 25, Issue:11 | Investigation of aryl isonitrile compounds with potent, broad-spectrum antifungal activity. |
| AID1609934 | Inhibition of Candida albicans CYP51 assessed as increase in lanosterol level at 0.25 ug/ml incubated for 18 hrs by GC/MS analysis relative to control | |||
| AID521108 | Antifungal activity against Aspergillus fumigatus AF4215 spectrophotometry | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Isobolographic analysis of pharmacodynamic interactions between antifungal agents and ciprofloxacin against Candida albicans and Aspergillus fumigatus. |
| AID555021 | Antifungal activity against Candida kefyr by reference dilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | In vitro activities of fluconazole and voriconazole against clinical isolates of Candida spp. determined by disk diffusion testing in Turin, Italy. |
| AID371230 | Antimicrobial activity against Candida parapsilosis ATCC 90018 by broth microdilution method | 2008 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 18, Issue:24 | Carbon analogs of antifungal dioxane-triazole derivatives: synthesis and in vitro activities. |
| AID521507 | Antifungal activity against Trichosporon asahii JCM 2466 after 48 hrs by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | In vitro and in vivo antifungal activities of T-2307, a novel arylamidine. |
| AID518177 | Antimicrobial activity against Cryptococcus gattii serotype B isolate NIH184 assessed as heteroresistant isolates at 2 ug/ml | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Heteroresistance of Cryptococcus gattii to fluconazole. |
| AID535619 | Antifungal activity against Candida tropicalis T19 blood stream isolate harboring Fks1p FLTLS/PLRDP mutant protein | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | Caspofungin-resistant Candida tropicalis strains causing breakthrough fungemia in patients at high risk for hematologic malignancies. |
| AID777331 | Antifungal activity against Sporothrix schenckii isolated from patient assessed as growth inhibition after 72 to 96 hrs by microbroth dilution method | 2013 | ACS medicinal chemistry letters, Oct-10, Volume: 4, Issue:10 | Identification of 1-[4-Benzyloxyphenyl)-but-3-enyl]-1H-azoles as New Class of Antitubercular and Antimicrobial Agents. |
| AID1287092 | Antimicrobial activity against antibiotic resistant Candida albicans clinical isolate 08030401 after 16 hrs by broth dilution method | 2016 | Journal of medicinal chemistry, Mar-10, Volume: 59, Issue:5 | A Designed Tryptophan- and Lysine/Arginine-Rich Antimicrobial Peptide with Therapeutic Potential for Clinical Antibiotic-Resistant Candida albicans Vaginitis. |
| AID285697 | Serum trough levels in Wistar rat pup at 10 mg/kg of body weight/day, ip after 96 hrs by ELISA | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Neonatal coinfection model of coagulase-negative Staphylococcus (Staphylococcus epidermidis) and Candida albicans: fluconazole prophylaxis enhances survival and growth. |
| AID530959 | Antifungal activity against Cryptococcus neoformans ATCC 90113 after 72 hrs by CLSI method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Potent in vitro antifungal activities of naturally occurring acetylenic acids. |
| AID678585 | Antifungal activity against Candida krusei Berkout KCCM 11655 after 1 day by twofold broth dilution method | 2012 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 22, Issue:18 | Synthesis and antifungal activity of 1-thia-4b-aza-cyclopenta[b]fluorene-4,10-diones. |
| AID518666 | Antimicrobial activity against Cryptococcus gattii serotype B isolate B5765 assessed as heteroresistant isolates at 8 ug/ml | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Heteroresistance of Cryptococcus gattii to fluconazole. |
| AID675302 | Antibacterial activity against Staphylococcus aureus ATCC 25293 by two fold broth dilution method | 2012 | Bioorganic & medicinal chemistry letters, Sep-01, Volume: 22, Issue:17 | Design, synthesis and evaluation of clinafloxacin triazole hybrids as a new type of antibacterial and antifungal agents. |
| AID1885984 | Antifungal activity against Candida glabrata ATCC1182 assessed as fungal growth inhibition incubated for 48 hrs in presence of P163-0892 by broth microdilution method | |||
| AID48067 | In vitro antifungal activity against Candida parapsilosis | 2003 | Journal of medicinal chemistry, Feb-13, Volume: 46, Issue:4 | Structure-based de novo design, synthesis, and biological evaluation of non-azole inhibitors specific for lanosterol 14alpha-demethylase of fungi. |
| AID564270 | Antifungal activity against Candida albicans isolate 14 after 48 hrs by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | A clinical isolate of Candida albicans with mutations in ERG11 (encoding sterol 14alpha-demethylase) and ERG5 (encoding C22 desaturase) is cross resistant to azoles and amphotericin B. |
| AID1740328 | Antifungal activity against Candida albicans ATCC 10231 assessed as reduction in fungal growth incubated for 48 hrs by broth microdilution method | 2020 | European journal of medicinal chemistry, Sep-15, Volume: 202 | Design, synthesis and antimicrobial evaluation of novel glycosylated-fluoroquinolones derivatives. |
| AID486968 | Antifungal activity against Candida parapsilosis ATCC 22019 after 48 hrs by micro broth dilution method | 2010 | European journal of medicinal chemistry, Jun, Volume: 45, Issue:6 | 'On water' assisted synthesis and biological evaluation of nitrogen and sulfur containing hetero-1,4-naphthoquinones as potent antifungal and antibacterial agents. |
| AID613456 | Antifungal activity against Fusarium oxysporum isolate NCL5 after 48 hrs by broth dilution method | 2011 | European journal of medicinal chemistry, Sep, Volume: 46, Issue:9 | Stereoselective synthesis and antimicrobial activity of steroidal C-20 tertiary alcohols with thiazole/pyridine side chain. |
| AID283844 | Antifungal activity against Trichophyton mentagrophytes after 3 to 4 days by serial plate dilution method | 2007 | European journal of medicinal chemistry, Jan, Volume: 42, Issue:1 | Synthesis and antimicrobial studies on novel chloro-fluorine containing hydroxy pyrazolines. |
| AID1495981 | Antifungal activity against Trichophyton mentagrophytes | 2018 | Bioorganic & medicinal chemistry, 07-23, Volume: 26, Issue:12 | Efficiency of newly prepared thiazole derivatives against some cutaneous fungi. |
| AID477307 | Antifungal activity against Rhizopus after 1 to 7 days by twofold serial dilution method | 2010 | European journal of medicinal chemistry, Apr, Volume: 45, Issue:4 | Synthesis and in vitro microbiological evaluation of an array of biolabile 2-morpholino-N-(4,6-diarylpyrimidin-2-yl)acetamides. |
| AID1904259 | Antifungal activity against Candida tropicalis 10186 assessed as inhibition of fungal growth incubated for 48 hrs by microdilution method | 2022 | Journal of medicinal chemistry, 05-12, Volume: 65, Issue:9 | Discovery of Novel Sertraline Derivatives as Potent Anti- |
| AID1738716 | Inhibition of CYP51 in azole-resistant Candida albicans ATCC SC531 assessed as ergosterol level at 0.125 ug/ml incubated for 16 hrs by LC-MS analysis relative to control | 2020 | European journal of medicinal chemistry, Jul-15, Volume: 198 | Design, synthesis, and biological evaluation of novel miconazole analogues containing selenium as potent antifungal agents. |
| AID1742127 | Antifungal activity against Candida krusei assessed as inhibition of microbial growth by two fold broth microdilution method | 2020 | European journal of medicinal chemistry, Nov-01, Volume: 205 | Design, synthesis and bioactivity evaluation of novel arylalkene-amide derivatives as dual-target antifungal inhibitors. |
| AID372249 | Fungicidal activity against Candida albicans SSK23 assessed as reduction in cell viability at 4 times MIC of SSK21/CHK21 after 24 hrs | 2007 | Antimicrobial agents and chemotherapy, Oct, Volume: 51, Issue:10 | The Ssk1p response regulator and Chk1p histidine kinase mutants of Candida albicans are hypersensitive to fluconazole and voriconazole. |
| AID279101 | Mortality rate in Candida albicans infected candidemia patient | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Association of fluconazole area under the concentration-time curve/MIC and dose/MIC ratios with mortality in nonneutropenic patients with candidemia. |
| AID386932 | Antifungal activity against Candida parapsilosis ATCC 22019 after 48 hrs by broth microdilution technique | 2008 | European journal of medicinal chemistry, Oct, Volume: 43, Issue:10 | Carbodithioic acid esters of fluoxetine, a novel class of dual-function spermicides. |
| AID772325 | Antifungal activity against fluconazole-resistant Candida albicans DSY292 harboring ERG11 gene mutant and increase expressing of MDR1 gene after 24 hrs by visually and spectrophotometric analysis | 2013 | ACS medicinal chemistry letters, Sep-12, Volume: 4, Issue:9 | Novel Macrocyclic Amidinoureas: Potent Non-Azole Antifungals Active against Wild-Type and Resistant Candida Species. |
| AID1546087 | Antimicrobial activity against Escherichia coli | 2019 | European journal of medicinal chemistry, Dec-15, Volume: 184 | Current scenario of tetrazole hybrids for antibacterial activity. |
| AID48959 | Tested in vitro for the minimum inhibitory concentration (MIC) against Candida albicans ATCC 24433 | 2002 | Bioorganic & medicinal chemistry letters, Mar-11, Volume: 12, Issue:5 | Synthesis of Sordaricin analogues as potent antifungal agents against Candida albicans. |
| AID1628393 | Antimicrobial activity against Candida mycoderma ATCC 9888 incubated for 24 hrs by NCCLS protocol based method | 2016 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 26, Issue:12 | Discovery of novel berberine imidazoles as safe antimicrobial agents by down regulating ROS generation. |
| AID285862 | Antimicrobial susceptibility of Pichia anomala from nosocomial fungemia patient assessed as percent susceptible isolates at 16 ug/ml by CLSI method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Antifungal drug susceptibility profile of Pichia anomala isolates from patients presenting with nosocomial fungemia. |
| AID276390 | Antifungal activity against Aspergillus fumigatus by broth microdilution technique | 2006 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 16, Issue:22 | Naphtho[2,3-b][1,4]-thiazine-5,10-diones and 3-substituted-1,4-dioxo-1,4-dihydronaphthalen-2-yl-thioalkanoate derivatives: synthesis and biological evaluation as potential antibacterial and antifungal agents. |
| AID269986 | Antifungal activity against Candida krusei 638 | 2006 | Journal of medicinal chemistry, Aug-10, Volume: 49, Issue:16 | Synthesis and antifungal activity of a novel series of alkyldimethylamine cyanoboranes and their derivatives. |
| AID1758050 | Antifungal activity against Candida albicans ATCC SC5314 infected in mouse model of candidiasis assessed as reduction in kidney fungal burden at 0.6 mg/kg/day, ip dosed at 2 hrs post infection and dosed for 4 days | 2021 | European journal of medicinal chemistry, Apr-15, Volume: 216 | Lead optimization generates selenium-containing miconazole CYP51 inhibitors with improved pharmacological profile for the treatment of fungal infections. |
| AID249319 | In vitro concentration causing 50% inhibition of Candida albicans with percentage of resistant strains %R = 45.45 (MIC > 64 ug/mL) at a range of 0.125-0.5 ug/mL | 2005 | Journal of medicinal chemistry, Aug-11, Volume: 48, Issue:16 | Antifungal agents. 11. N-substituted derivatives of 1-[(aryl)(4-aryl-1H-pyrrol-3-yl)methyl]-1H-imidazole: synthesis, anti-Candida activity, and QSAR studies. |
| AID1481570 | Antifungal activity against Candida utilis after 24 hrs by two-fold serial dilution assay | 2017 | Bioorganic & medicinal chemistry letters, 04-15, Volume: 27, Issue:8 | Novel benzimidazolyl tetrahydroprotoberberines: Design, synthesis, antimicrobial evaluation and multi-targeting exploration. |
| AID1550460 | Antifungal activity against Candida albicans ATCC 90028 assessed as diameter of zone inhibition at 0.025 mg incubated for 24 hrs by disc diffusion method | 2019 | European journal of medicinal chemistry, Jun-01, Volume: 171 | Antimicrobial and KPC/AmpC inhibitory activity of functionalized benzosiloxaboroles. |
| AID546068 | Antifungal activity against Candida albicans isolated from candidemia patient by AFST-EUCAST microdilution method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | A 10-year survey of antifungal susceptibility of candidemia isolates from intensive care unit patients in Greece. |
| AID323595 | Antifungal activity against Candida glabrata bloodstream isolates by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5 | In vitro activities of isavuconazole and other antifungal agents against Candida bloodstream isolates. |
| AID351882 | Binding affinity to Mycobacterium tuberculosis His4-tagged recombinant CYP51 F78L mutant expressed in Escherichia coli HMS174(DE3) by UV-visible spectral titration method | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Small-molecule scaffolds for CYP51 inhibitors identified by high-throughput screening and defined by X-ray crystallography. |
| AID619596 | Antifungal activity against Candida parapsilosis after 24 hrs by broth microdilution method | 2011 | Bioorganic & medicinal chemistry, Oct-01, Volume: 19, Issue:19 | Antifungal activity of a series of 1,2-benzisothiazol-3(2H)-one derivatives. |
| AID714932 | Antimicrobial activity against Aspergillus flavus NCIM 524 at 100 ug/mL incubated for 48 hrs by agar disc diffusion method | 2012 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 22, Issue:23 | Synthesis, characterization, antidepressant and antioxidant activity of novel piperamides bearing piperidine and piperazine analogues. |
| AID515008 | Antifungal activity against Candida albicans SC5314 after 24 hrs by micro-broth dilution method | 2010 | European journal of medicinal chemistry, Oct, Volume: 45, Issue:10 | Synthesis and antifungal evaluation of novel triazole derivatives as inhibitors of cytochrome P450 14alpha-demethylase. |
| AID1762146 | Aqueous solubility, log S of compound in buffer at pH 7.4 | 2021 | Bioorganic & medicinal chemistry letters, 05-15, Volume: 40 | Synthesis and antifungal activity of new hybrids thiazolo[4,5-d]pyrimidines with (1H-1,2,4)triazole. |
| AID549016 | Antimicrobial activity against Candida krusei LMR 39-14 infected in immunosuppressed CF-1 mouse assessed as decrease in kidney bacterial burden at 40 mg/kg, ip administered once daily for 5 days measured after 5 days (Rvb= 6.66) | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Activity of anidulafungin in a murine model of Candida krusei infection: evaluation of mortality and disease burden by quantitative tissue cultures and measurement of serum (1,3)-beta-D-glucan levels. |
| AID1890291 | Cytotoxicity against mouse NIH/3T3 cells assessed as reduction in cell viability at 200 ug/ml incubated for 48 hrs by MTT assay (Rvb = 93.8 +/- 4.9 %) | 2022 | Bioorganic & medicinal chemistry letters, 05-01, Volume: 63 | Novel 2-aryl-4-aryloxyquinoline-based fungistatics for Mucor circinelloides. Biological evaluation of activity, QSAR and docking study. |
| AID670398 | Antifungal activity against Candida parapsilosis MTCC 3018 by well diffusion method | 2012 | Bioorganic & medicinal chemistry letters, Jul-15, Volume: 22, Issue:14 | Synthesis, biological evaluation of 5-carbomethoxymethyl-7-hydroxy-2-pentylchromone, 5-carboethoxymethyl-4',7-dihydroxyflavone and their analogues. |
| AID1885986 | Antifungal activity against Candida parapsilosis ATCC22019 assessed as fungal growth inhibition incubated for 48 hrs in presence of P163-0892 by broth microdilution method | |||
| AID1337066 | Antifungal activity against fluconazole-resistant Candida albicans clinical isolate 36 | 2017 | ACS medicinal chemistry letters, Feb-09, Volume: 8, Issue:2 | Potent Antifungal Synergy of Phthalazinone and Isoquinolones with Azoles Against |
| AID1758009 | Antifungal activity against fluconazole-resistant Candida albicans CaR assessed as inhibition of microbial growth after 24 hrs by broth microdilution method | 2021 | European journal of medicinal chemistry, Apr-15, Volume: 216 | Lead optimization generates selenium-containing miconazole CYP51 inhibitors with improved pharmacological profile for the treatment of fungal infections. |
| AID532564 | Antifungal activity against wild-type Saccharomyces cerevisiae BY4741 assessed as accumulation of lanosterol at 16 ug/ml (Rvb = 17+/- 1.22 %) | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | Differential azole antifungal efficacies contrasted using a Saccharomyces cerevisiae strain humanized for sterol 14 alpha-demethylase at the homologous locus. |
| AID420661 | Antifungal activity against Cryptococcus neoformans ATCC 32609 after 72 hrs by micro-broth dilution method | 2009 | European journal of medicinal chemistry, May, Volume: 44, Issue:5 | Design, synthesis, and biological evaluation of novel triazole derivatives as inhibitors of cytochrome P450 14alpha-demethylase. |
| AID1303301 | Antimicrobial activity against Candida albicans ATCC 10231 after 24 hrs by microbroth dilution method | 2016 | Bioorganic & medicinal chemistry letters, 06-01, Volume: 26, Issue:11 | Design, synthesis and biological evaluation of 5-fluorouracil-derived benzimidazoles as novel type of potential antimicrobial agents. |
| AID405061 | Antifungal activity against Sporothrix schenckii P30915 isolate from cutaneous-lymphatic sporotrichosis patient after 72 hrs by Sensititre YeastOne method | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | In vitro susceptibility of Sporothrix schenckii to six antifungal agents determined using three different methods. |
| AID1411848 | Antifungal activity against fluconazole resistant Candida albicans 167-2 by CLSI protocol based broth microdilution method | 2017 | MedChemComm, Dec-01, Volume: 8, Issue:12 | Synergistic antifungal effect of cyclized chalcone derivatives and fluconazole against |
| AID518652 | Antimicrobial activity against Cryptococcus gattii serotype B isolate NIH198 assessed as heteroresistant isolates at 8 ug/ml | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Heteroresistance of Cryptococcus gattii to fluconazole. |
| AID547602 | Antifungal activity against Candida glabrata isolate Cg7S | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | Microarray and molecular analyses of the azole resistance mechanism in Candida glabrata oropharyngeal isolates. |
| AID1886049 | Synergistic antifungal activity against Cryptococcus neoformans clinical isolate 444 assessed as fractional inhibitory concentration index incubated for 72 hrs in presence of P163-0892 by broth microdilution method | |||
| AID1246772 | Antifungal activity against Cryptococcus gattii ATCC 32608 after 48 to 72 hrs by broth microdilution method | 2015 | European journal of medicinal chemistry, Sep-18, Volume: 102 | Thiazole compounds with activity against Cryptococcus gattii and Cryptococcus neoformans in vitro. |
| AID1348084 | Antimicrobial activity against Candida albicans ATCC 10231 assessed as zone of inhibition at 50 ug per disc after 48 hrs by disc diffusion assay | 2018 | European journal of medicinal chemistry, Jan-01, Volume: 143 | Synthesis of new 1-benzyl tetrahydropyridinylidene ammonium salts and their antimicrobial and anticellular activities. |
| AID546081 | Antifungal activity against Candida intermedia isolated from candidemia patient by AFST-EUCAST microdilution method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | A 10-year survey of antifungal susceptibility of candidemia isolates from intensive care unit patients in Greece. |
| AID1198411 | Anticandidal activity against Candida glabrata ATCC 90030 incubated at 37 degC for 24 hrs by broth dilution method | 2015 | European journal of medicinal chemistry, Mar-26, Volume: 93 | Synthesis, QSAR and anticandidal evaluation of 1,2,3-triazoles derived from naturally bioactive scaffolds. |
| AID582767 | Antifungal activity against Candida albicans isolate 177 assessed as ergosterol content in total sterol composition at 0.5 times MIC by GC-MS analysis | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | Identification and characterization of four azole-resistant erg3 mutants of Candida albicans. |
| AID1592215 | Antifungal activity against Candida glabrata ATCC 0001 assessed as inhibition of microbial growth by NCCLS protocol based method | 2019 | Bioorganic & medicinal chemistry, 06-15, Volume: 27, Issue:12 | Design, synthesis and biological evaluation of amide-pyridine derivatives as novel dual-target (SE, CYP51) antifungal inhibitors. |
| AID693582 | Antifungal activity against Candida albicans MTCC 183 after 48 hrs by tube dilution method | 2012 | European journal of medicinal chemistry, Dec, Volume: 58 | Synthesis pharmacological evaluation and docking studies of pyrimidine derivatives. |
| AID1168325 | Binding affinity to human serum albumin assessed as formation of non-fluorescent compound-protein complex at 302 K at pH 7.4 by fluorescence quenching method | 2014 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 24, Issue:21 | Study the interactions between human serum albumin and two antifungal drugs: fluconazole and its analogue DTP. |
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| AID406954 | Cytotoxicity against human K562 cells after assessed as reduction of cell viability 24 hrs by MTT assay | 2008 | Journal of medicinal chemistry, Jul-10, Volume: 51, Issue:13 | 1-[(3-Aryloxy-3-aryl)propyl]-1H-imidazoles, new imidazoles with potent activity against Candida albicans and dermatophytes. Synthesis, structure-activity relationship, and molecular modeling studies. |
| AID567443 | Antifungal activity against Trichosporon asahii after 48 hrs by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | In vitro antifungal activities of isavuconazole and comparators against rare yeast pathogens. |
| AID567446 | Antifungal activity against Trichosporon mucoides assessed as percent susceptible/dose-dependent isolates after 48 hrs by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | In vitro antifungal activities of isavuconazole and comparators against rare yeast pathogens. |
| AID637164 | Antifungal activity against Candida tropicalis ATCC 20336 at 25 mg/ml after 72 hrs by agar diffusion test | 2012 | European journal of medicinal chemistry, Feb, Volume: 48 | Synthesis and in vitro antimycobacterial activity of compounds derived from (R)- and (S)-2-amino-1-butanol - The crucial role of the configuration. |
| AID1742129 | Antifungal activity against Aspergillus fumigatus assessed as inhibition of microbial growth by two fold broth microdilution method | 2020 | European journal of medicinal chemistry, Nov-01, Volume: 205 | Design, synthesis and bioactivity evaluation of novel arylalkene-amide derivatives as dual-target antifungal inhibitors. |
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| AID553852 | Antifungal activity against wild type Candida albicans 10261 in RPMI-1640 buffered medium after 24 hrs by microdilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | Enhanced susceptibility to antifungal oligopeptides in yeast strains overexpressing ABC multidrug efflux pumps. |
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| AID776434 | Antifungal activity against Aspergillus flavus ATCC 11495 after 24 hrs by microdilution technique | 2013 | European journal of medicinal chemistry, Nov, Volume: 69 | Synthesis, antimicrobial, antioxidant activities of novel 6-aryl-5-cyano thiouracil derivatives. |
| AID1154818 | Antifungal activity against Aspergillus fumigatus 07544 after 7 days by serial dilution method | 2014 | ACS medicinal chemistry letters, May-08, Volume: 5, Issue:5 | Novel carboline derivatives as potent antifungal lead compounds: design, synthesis, and biological evaluation. |
| AID574613 | Antifungal activity against Aspergillus fumigatus 231 after 48 hrs by broth microdilution method | 2011 | Bioorganic & medicinal chemistry, Feb-15, Volume: 19, Issue:4 | Synthesis and antimycobacterial properties of N-substituted 6-amino-5-cyanopyrazine-2-carboxamides. |
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| AID1651343 | Antifungal activity against Aspergillus fumigatus 7544 by NCCLS protocol based broth microdilution assay | 2020 | Bioorganic & medicinal chemistry letters, 02-15, Volume: 30, Issue:4 | Design, synthesis, and structure-activity relationship studies of novel triazole agents with strong antifungal activity against Aspergillus fumigatus. |
| AID1864930 | Antifungal activity against Candida albicans ATCC SC5314 assessed as decrease in fungal cell density measured at 48 hrs by fluorescence microscopy (Rvb = 258%) | |||
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| AID1419501 | Antifungal activity against Candida krusei ATCC 6258 incubated for 48 hrs by modified CLSI M27-A3 protocol based method | 2017 | European journal of medicinal chemistry, Jun-16, Volume: 133 | Novel alkylated azoles as potent antifungals. |
| AID567861 | Neurotoxicity in rat assessed as impair in motor coordination at after 30 mins by rotarod test (Rvb = 116.50 +/- 1.18 sec) | 2011 | European journal of medicinal chemistry, Feb, Volume: 46, Issue:2 | Synthesis, antidepressant and antifungal evaluation of novel 2-chloro-8-methylquinoline amine derivatives. |
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| AID1063946 | Antifungal activity against Absidia corymbifera 272 after 24 hrs by broth microdilution method | 2014 | Bioorganic & medicinal chemistry, Jan-15, Volume: 22, Issue:2 | Salicylanilide diethyl phosphates: synthesis, antimicrobial activity and cytotoxicity. |
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| AID1352426 | Antifungal activity against Candida parapsilosis ATCC 22019 by CLSI two fold serial dilution method | 2018 | European journal of medicinal chemistry, Feb-25, Volume: 146 | Discovery of 2-aminothiazolyl berberine derivatives as effectively antibacterial agents toward clinically drug-resistant Gram-negative Acinetobacter baumanii. |
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| AID1391316 | Antibacterial activity against Escherichia coli 1924 after 24 hrs by two-fold serial dilution method | 2018 | Bioorganic & medicinal chemistry letters, 05-15, Volume: 28, Issue:9 | Synthesis and evaluation of the antibacterial activities of aryl substituted dihydrotriazine derivatives. |
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| AID667134 | Antifungal activity against Aspergillus niger MTCC 282 after 120 hrs by serial dilution method | 2012 | Bioorganic & medicinal chemistry letters, Jul-01, Volume: 22, Issue:13 | Regioselective synthesis and antimicrobial studies of ester linked 1,4-disubstituted 1,2,3-bistriazoles. |
| AID1274485 | Antifungal activity against Candida albicans CMCC 76615 after 48 hrs by microdilution method | 2016 | European journal of medicinal chemistry, Jan-27, Volume: 108 | Synthesis and biological evaluation of novel phosphoramidate derivatives of coumarin as chitin synthase inhibitors and antifungal agents. |
| AID1861423 | Antifungal activity against clinical strain Candida albicans CA808 assessed as inhibition of fungal growth by microdilution method | 2022 | Bioorganic & medicinal chemistry letters, 09-01, Volume: 71 | Discovery of novel indole and indoline derivatives against Candida albicans as potent antifungal agents. |
| AID432803 | Antifungal activity against Sporothrix albicans after 72 hrs by microdilution method | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | In vitro antifungal susceptibilities of five species of sporothrix. |
| AID1592226 | Antifungal activity against Candida albicans assessed as inhibition of microbial growth at 2.5 nM/mL by polarizing microscopy | 2019 | Bioorganic & medicinal chemistry, 06-15, Volume: 27, Issue:12 | Design, synthesis and biological evaluation of amide-pyridine derivatives as novel dual-target (SE, CYP51) antifungal inhibitors. |
| AID1737522 | Antifungal activity against Candida albicans ATCC 90023 incubated for 48 hrs by two-fold broth dilution analysis | 2020 | European journal of medicinal chemistry, Jun-01, Volume: 195 | Design, synthesis and biological evaluation of novel 3,4-dihydro-2(1H)-quinolinone derivatives as potential chitin synthase inhibitors and antifungal agents. |
| AID751637 | Antifungal activity against Aspergillus flavus at 100 ppm | 2013 | European journal of medicinal chemistry, Feb, Volume: 60 | Synthesis and antifungal activity of some s-mercaptotriazolobenzothiazolyl amino acid derivatives. |
| AID1154819 | Antifungal activity against Trichophyton rubrum Cmccftla after 7 days by serial dilution method | 2014 | ACS medicinal chemistry letters, May-08, Volume: 5, Issue:5 | Novel carboline derivatives as potent antifungal lead compounds: design, synthesis, and biological evaluation. |
| AID1556216 | Inhibition of CYP51 in Candida albicans ATCC SC5314 assessed as ergosterol level at 0.5 ug/ml incubated for 16 hrs by GC/MS analysis (Rvb = 100%) | 2019 | European journal of medicinal chemistry, Sep-01, Volume: 177 | Design, synthesis, and structure-activity relationship studies of l-amino alcohol derivatives as broad-spectrum antifungal agents. |
| AID301020 | Antifungal activity against Candida glabrata HO3 at 250 ug/ml after 48 hrs by agar well diffusion technique | 2007 | Bioorganic & medicinal chemistry letters, Oct-01, Volume: 17, Issue:19 | Synthesis and antimicrobial evaluation of new chalcones containing piperazine or 2,5-dichlorothiophene moiety. |
| AID1430055 | Anti-fungal activity against Aspergillus fumigatus after 48 hrs by broth microdilution method | |||
| AID1809929 | Induction of drug resistant in Candida glabrata BG2 assessed as increase in FCZ IC50 at 16 times IC50 | 2021 | Journal of medicinal chemistry, 11-11, Volume: 64, Issue:21 | Optimization and Evaluation of Novel Antifungal Agents for the Treatment of Fungal Infection. |
| AID1328365 | Cytotoxicity against African green monkey Vero cells assessed as reduction in viable cells measured after 48 hrs by neutral red dye-based method | 2016 | Journal of natural products, 09-23, Volume: 79, Issue:9 | Synthesis of Natural Acylphloroglucinol-Based Antifungal Compounds against Cryptococcus Species. |
| AID1600166 | Antibacterial activity against Escherichia coli NCIM 2574 assessed as zone of inhibition at 80 ug/well incubated for 24 to 48 hrs by by agar well diffusion method | 2019 | European journal of medicinal chemistry, Oct-01, Volume: 179 | Synthesis of new thiazolyl-pyrazolyl-1,2,3-triazole derivatives as potential antimicrobial agents. |
| AID1852899 | Inhibition of Candida albicans CYP51 assessed as ergosterol level incubated for 18 hrs by GC/MS analysis relative to control | 2022 | RSC medicinal chemistry, Nov-16, Volume: 13, Issue:11 | Efficient selective targeting of |
| AID1584735 | Drug metabolism in mouse liver microsome S9 fraction assessed as CYP450-mediated metabolism by measuring compound remaining at 5 uM pretreated with NADPH and measured after 30 mins by UPLC-MS/MS analysis | 2018 | Journal of medicinal chemistry, 10-25, Volume: 61, Issue:20 | Discovery of Novel 7-Aryl 7-Deazapurine 3'-Deoxy-ribofuranosyl Nucleosides with Potent Activity against Trypanosoma cruzi. |
| AID518406 | Antimicrobial activity against Cryptococcus gattii serotype B isolate NIH771 assessed as heteroresistant isolates at 2 ug/ml | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Heteroresistance of Cryptococcus gattii to fluconazole. |
| AID518410 | Antimicrobial activity against Cryptococcus gattii serotype B isolate B5765 assessed as heteroresistant isolates at 2 ug/ml | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Heteroresistance of Cryptococcus gattii to fluconazole. |
| AID509275 | Permeability across BBMEC cocultured with rat C6 cell BBB model after 24 hrs in presence of 0.1 ug/ml TNF | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Effects of immunomodulatory and organism-associated molecules on the permeability of an in vitro blood-brain barrier model to amphotericin B and fluconazole. |
| AID555023 | Antifungal activity against Candida sp. by reference dilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | In vitro activities of fluconazole and voriconazole against clinical isolates of Candida spp. determined by disk diffusion testing in Turin, Italy. |
| AID775726 | Antifungal activity against Penicillium chrysogenum assessed as growth inhibition after 48 to 72 hrs by broth microdilution method | 2013 | European journal of medicinal chemistry, Nov, Volume: 69 | Microwave assisted synthesis of dihydrobenzo[4,5]imidazo[1,2-a]pyrimidin-4-ones; synthesis, in vitro antimicrobial and anticancer activities of novel coumarin substituted dihydrobenzo[4,5]imidazo[1,2-a]pyrimidin-4-ones. |
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| AID1246596 | Antifungal activity against Cryptococcus neoformans 27JF after 48 to 72 hrs by broth microdilution method | 2015 | European journal of medicinal chemistry, Sep-18, Volume: 102 | Thiazole compounds with activity against Cryptococcus gattii and Cryptococcus neoformans in vitro. |
| AID1551801 | Antibacterial activity against Proteus mirabilis ATCC 35659 after 24 hrs by microdilution method | 2019 | European journal of medicinal chemistry, Jul-01, Volume: 173 | Antibacterial activity study of 1,2,4-triazole derivatives. |
| AID1246595 | Antifungal activity against Cryptococcus neoformans VM-MCMMPI after 48 to 72 hrs by broth microdilution method | 2015 | European journal of medicinal chemistry, Sep-18, Volume: 102 | Thiazole compounds with activity against Cryptococcus gattii and Cryptococcus neoformans in vitro. |
| AID1601666 | Antibiofilm activity against Candida albicans PMC 1082 assessed as inhibition of mature biofilm formation by XTT reduction assay | |||
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| AID301282 | Spermicidal activity against human spermatozoa | 2007 | Bioorganic & medicinal chemistry, Nov-01, Volume: 15, Issue:21 | Synthesis of disulfide esters of dialkylaminocarbothioic acid as potent, non-detergent spermicidal agents. |
| AID1864894 | Antifungal activity against fluconazole -resistant Candida albicans 901 assessed as fungal growth inhibition measured after 72 hrs by double dilution method | |||
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| AID302116 | Antifungal activity against Candida parapsilosis after 24 hrs | 2007 | Journal of medicinal chemistry, Nov-01, Volume: 50, Issue:22 | Synthesis and antifungal activities of novel 2-aminotetralin derivatives. |
| AID1904389 | Antibiofilm activity against Candida albicans CPCC40061 assessed as inhibition of bacterial metabolism activity in the biofilm measured after 48 hrs by XTT reduction assay | 2022 | European journal of medicinal chemistry, Apr-05, Volume: 233 | Design, synthesis, and evaluation of novel 3-thiophene derivatives as potent fungistatic and fungicidal reagents based on a conformational restriction strategy. |
| AID1391312 | Antibacterial activity against quinolone-resistant Staphylococcus aureus isolate CCARM 3505 after 24 hrs by two-fold serial dilution method | 2018 | Bioorganic & medicinal chemistry letters, 05-15, Volume: 28, Issue:9 | Synthesis and evaluation of the antibacterial activities of aryl substituted dihydrotriazine derivatives. |
| AID407065 | Antimicrobial activity against Candida albicans planktonic forms | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | Role for cell density in antifungal drug resistance in Candida albicans biofilms. |
| AID530965 | Antifungal activity against Aspergillus fumigatus ATCC 204305 at 163.3 uM after 48 hrs by CLSI method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Potent in vitro antifungal activities of naturally occurring acetylenic acids. |
| AID47868 | Evaluation of In vitro antifungal activity against Candida parapsilosis C74 by broth macro dilution method | 1995 | Journal of medicinal chemistry, Sep-29, Volume: 38, Issue:20 | Synthesis and antifungal activity of new azole derivatives containing an N-acylmorpholine ring. |
| AID1394707 | Antifungal activity against fluconazole-resistant Candida albicans TTSH-CALB01 after overnight incubation by CLSI broth microdilution method | 2018 | European journal of medicinal chemistry, Apr-25, Volume: 150 | Structure-activity relationship studies of ultra-short peptides with potent activities against fluconazole-resistant Candida albicans. |
| AID1491245 | Antifungal activity against Aspergillus fumigatus GIM 3.524 by broth microdilution method | 2017 | European journal of medicinal chemistry, Sep-08, Volume: 137 | Design, synthesis and evaluation of aromatic heterocyclic derivatives as potent antifungal agents. |
| AID581879 | Antifungal activity against Candida glabrata isolated from HSCT recipient 186 with acute or chronic GVHD mouth receiving antifungal drug after 112 days prophylaxis by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Impact of antifungal prophylaxis on colonization and azole susceptibility of Candida species. |
| AID1326660 | Antifungal activity against Aspergillus flavus measured after 24 hrs by two-fold serial dilution method | 2016 | European journal of medicinal chemistry, Oct-21, Volume: 122 | Design, synthesis and biological evaluation of berberine-benzimidazole hybrids as new type of potentially DNA-targeting antimicrobial agents. |
| AID582217 | Antifungal activity against Candida albicans isolated from HSCT recipients with acute or chronic GVHD receiving posaconazole by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Impact of antifungal prophylaxis on colonization and azole susceptibility of Candida species. |
| AID1422685 | Antifungal activity against Candida albicans after 24 hrs by two fold serial dilution method | 2018 | Bioorganic & medicinal chemistry, 11-01, Volume: 26, Issue:20 | Antifungal benzo[b]thiophene 1,1-dioxide IMPDH inhibitors exhibit pan-assay interference (PAINS) profiles. |
| AID185222 | Minimum inhibitory concentration against Candida albicans (CCH442) tested in rats | 2003 | Bioorganic & medicinal chemistry letters, Feb-10, Volume: 13, Issue:3 | In vivo characterization of A-192411: a novel fungicidal lipopeptide (II). |
| AID385149 | Antifungal activity against Aspergillus fumigatus ATCC 10894 at 100 ug/ml after 48 hrs by agar diffusion assay | 2008 | Journal of natural products, Apr, Volume: 71, Issue:4 | Antifungal metabolites from the plant endophytic fungus Pestalotiopsis foedan. |
| AID424636 | Antimicrobial activity against azole-resistant Candida albicans isolate CA135 cotreated with calcineurin signaling inhibitor Tacrolimus after 48 hrs by microdilution checkerboard technique | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | In vitro interactions between tacrolimus and azoles against Candida albicans determined by different methods. |
| AID1719173 | Antifungal activity against Candida albicans ATCC 10231 assessed as reduction in microbial growth | 2021 | Bioorganic & medicinal chemistry letters, 03-01, Volume: 35 | A new 1-nitro-9-aminoacridine derivative targeting yeast topoisomerase II able to overcome fluconazole-resistance. |
| AID276389 | Antifungal activity against Cryptococcus neoformans by broth microdilution technique | 2006 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 16, Issue:22 | Naphtho[2,3-b][1,4]-thiazine-5,10-diones and 3-substituted-1,4-dioxo-1,4-dihydronaphthalen-2-yl-thioalkanoate derivatives: synthesis and biological evaluation as potential antibacterial and antifungal agents. |
| AID608538 | Antimicrobial activity against Bacillus subtilis ATCC 6633 after 24 hrs by microdilution technique | 2011 | European journal of medicinal chemistry, Jul, Volume: 46, Issue:7 | New condensed pyrroles of potential biological interest syntheses and structure-activity relationship studies. |
| AID1419505 | Antifungal activity against Aspergillus terreus ATCC MYA-3633 incubated for 48 hrs by CLSI M38-A2 protocol based method | 2017 | European journal of medicinal chemistry, Jun-16, Volume: 133 | Novel alkylated azoles as potent antifungals. |
| AID1877838 | Antifungal activity against Candida albicans CA602 by microdilution method | 2022 | Bioorganic & medicinal chemistry letters, 02-15, Volume: 58 | Synthesis and antifungal evaluation of phenol-derived bis(indolyl)methanes combined with FLC against Candida albicans. |
| AID1221957 | Apparent permeability from basolateral to apical side of human Caco2 cells at 10 uM up to 120 mins by HPLC-MC analysis | 2011 | Drug metabolism and disposition: the biological fate of chemicals, Feb, Volume: 39, Issue:2 | Attenuation of intestinal absorption by major efflux transporters: quantitative tools and strategies using a Caco-2 model. |
| AID1369505 | Binding affinity to phosphatidylcholine/phosphatidylethanolamine/phosphatidylinositol/ergosterol large unilamellar vesicle assessed as induction of calcein leakage at 2 to 32 uM after 15 mins by spectrofluorophotometric method | 2018 | Journal of medicinal chemistry, 05-10, Volume: 61, Issue:9 | Combating Drug-Resistant Fungi with Novel Imperfectly Amphipathic Palindromic Peptides. |
| AID567859 | Antifungal activity against Monascus purpureus MTCC 369 after 72 hrs | 2011 | European journal of medicinal chemistry, Feb, Volume: 46, Issue:2 | Synthesis, antidepressant and antifungal evaluation of novel 2-chloro-8-methylquinoline amine derivatives. |
| AID582793 | Antifungal activity against Candida albicans isolate 12 harboring ERG3 W332R mutant gene assessed as eburicol content in total sterol composition at 0.5 times MIC by GC-MS analysis | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | Identification and characterization of four azole-resistant erg3 mutants of Candida albicans. |
| AID531247 | Antifungal activity against Candida albicans assessed as resistant isolates after 48 hrs by CLSI method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | In vitro susceptibilities of invasive isolates of Candida species: rapid increase in rates of fluconazole susceptible-dose dependent Candida glabrata isolates. |
| AID125941 | In vitro evaluation of minimum inhibitory concentration against Microsporum canis 47 | 1995 | Journal of medicinal chemistry, Sep-29, Volume: 38, Issue:20 | Synthesis and antifungal activity of new azole derivatives containing an N-acylmorpholine ring. |
| AID1205757 | Antifungal activity against Cryptococcus neoformans ATCC 96806 after 72 hrs by microdilution method | 2015 | ACS medicinal chemistry letters, Mar-12, Volume: 6, Issue:3 | Synthesis of a New Peptide-Coumarin Conjugate: A Potential Agent against Cryptococcosis. |
| AID1628384 | Antimicrobial activity against Bacillus proteus ATCC13315 incubated for 24 hrs by NCCLS protocol based method | 2016 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 26, Issue:12 | Discovery of novel berberine imidazoles as safe antimicrobial agents by down regulating ROS generation. |
| AID525597 | Antibacterial activity against Fluconazole resistant Candida albicans DSY3752 containing (TAC1-5/TAC1-5 ERG11-1/ERG11-1) genotype by EUCAST standards based broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Genetic dissection of azole resistance mechanisms in Candida albicans and their validation in a mouse model of disseminated infection. |
| AID425653 | Renal clearance in human | 2009 | Journal of medicinal chemistry, Aug-13, Volume: 52, Issue:15 | Physicochemical determinants of human renal clearance. |
| AID1759468 | Antifungal activity against Cryptococcus neoformans PFCC 93-589 assessed as half minimum inhibitory concentration by broth microdilution assay | 2021 | Bioorganic & medicinal chemistry letters, 06-01, Volume: 41 | Inhibitory effects and mechanism of antifungal action of the natural cyclic depsipeptide, aureobasidin A against Cryptococcus neoformans. |
| AID405054 | Antifungal activity against Sporothrix schenckii PJRC002 isolate from cutaneous-lymphatic sporotrichosis patient after 72 hrs by modified NCCLS M38-A method | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | In vitro susceptibility of Sporothrix schenckii to six antifungal agents determined using three different methods. |
| AID29811 | Oral bioavailability in human | 2000 | Journal of medicinal chemistry, Jun-29, Volume: 43, Issue:13 | QSAR model for drug human oral bioavailability. |
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| AID519068 | Antifungal activity against Candida albicans ATCC 3153 after 48 hrs | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | Mechanism-based pharmacokinetic-pharmacodynamic models of in vitro fungistatic and fungicidal effects against Candida albicans. |
| AID470601 | Antifungal activity against Candida parapsilosis ATCC 22019 after 48 hrs by microbroth dilution technique | 2009 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 19, Issue:18 | Design and synthesis of bile acid-based amino sterols as antimicrobial agents. |
| AID566889 | Antifungal activity against Exophiala spinifera by microdilution test | 2011 | European journal of medicinal chemistry, Jan, Volume: 46, Issue:1 | Synthesis and antifungal activity of some substituted phenothiazines and related compounds. |
| AID1911622 | Antifungal activity against Candida parapsilosis ATCC 22019 assessed as fungal growth inhibition by broth microdilution assay | 2022 | Journal of medicinal chemistry, 06-09, Volume: 65, Issue:11 | Development of Lipo-γ-AA Peptides as Potent Antifungal Agents. |
| AID590521 | Antifungal activity against Aspergillus niger MTCC 282 assessed as inhibition of mycelial growth for 7 days by poisoned food method | 2011 | European journal of medicinal chemistry, Apr, Volume: 46, Issue:4 | Synthesis and biological evaluation of some 4-functionalized-pyrazoles as antimicrobial agents. |
| AID1598010 | Antifungal activity against Candida parapsilosis | 2019 | European journal of medicinal chemistry, May-15, Volume: 170 | Current advances of triazole alcohols derived from fluconazole: Design, in vitro and in silico studies. |
| AID1770950 | Inhibition of CYP51 in Candida albicans assessed as lanosterol level at 0.25 ug/ml measured after 18 hrs by GC-MS analysis relative to control | 2021 | European journal of medicinal chemistry, Dec-05, Volume: 225 | Design, synthesis and evaluation of novel 5-phenylthiophene derivatives as potent fungicidal of Candida albicans and antifungal reagents of fluconazole-resistant fungi. |
| AID425137 | Antimicrobial activity against azole-resistant Candida albicans isolate CA10 assessed as growth at 0.125 ug/ml after 48 hrs by microdilution checkerboard technique relative to control | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | In vitro interactions between tacrolimus and azoles against Candida albicans determined by different methods. |
| AID625832 | Antifungal activity against Sporothrix schenckii by broth microdilution method | 2011 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 21, Issue:21 | Micelles catalyzed chemoselective synthesis 'in water' and biological evaluation of oxygen containing hetero-1,4-naphthoquinones as potential antifungal agents. |
| AID595000 | Antifungal activity against Aspergillus fumigatus after 48 hrs | 2011 | Bioorganic & medicinal chemistry letters, May-15, Volume: 21, Issue:10 | Thermal solvent-free synthesis of novel pyrazolyl chalcones and pyrazolines as potential antimicrobial agents. |
| AID554722 | Fold resistant, ratio of MIC for Saccharomyces cerevisiae isolate ADdelta overexpressing Saccharomyces cerevisiae ERG11 to MIC for Saccharomyces cerevisiae isolate ADdelta overexpressing Abc1p | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Abc1p is a multidrug efflux transporter that tips the balance in favor of innate azole resistance in Candida krusei. |
| AID1905256 | Synergistic antifungal activity against fluconazole-resistant Candida albicans 103 assessed as inhibition of fungal growth in presence of fluconazole by checker board microdilution assay | 2022 | Journal of medicinal chemistry, 04-14, Volume: 65, Issue:7 | Species-Selective Targeting of Fungal Hsp90: Design, Synthesis, and Evaluation of Novel 4,5-Diarylisoxazole Derivatives for the Combination Treatment of Azole-Resistant Candidiasis. |
| AID518438 | Antimicrobial activity against Cryptococcus gattii serotype B isolate NIH367 assessed as heteroresistant isolates at 4 ug/ml | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Heteroresistance of Cryptococcus gattii to fluconazole. |
| AID582254 | Antifungal activity against Candida glabrata isolated from neutropenic subjects with AML or MDS receiving fluconazole by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Impact of antifungal prophylaxis on colonization and azole susceptibility of Candida species. |
| AID1762170 | Antifungal activity against Trichophyton rubrum 2002 assessed as reduction in fungal growth incubated for 24 hrs by CLSI based serial microbroth dilution method | 2021 | Bioorganic & medicinal chemistry letters, 05-15, Volume: 40 | Synthesis and antifungal activity of new hybrids thiazolo[4,5-d]pyrimidines with (1H-1,2,4)triazole. |
| AID1767310 | Hemolytic activity in human RBC | 2021 | European journal of medicinal chemistry, Oct-05, Volume: 221 | Discovery of novel purinylthiazolylethanone derivatives as anti-Candida albicans agents through possible multifaceted mechanisms. |
| AID555002 | Antifungal activity against Candida krusei assessed as dose dependent percent susceptible isolates at 25 ug/disc by CLSI M44-A disk diffusion method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | In vitro activities of fluconazole and voriconazole against clinical isolates of Candida spp. determined by disk diffusion testing in Turin, Italy. |
| AID1430408 | Antifungal activity against Candida krusei G06 after 24 to 48 hrs by macro-broth dilution method | 2017 | Bioorganic & medicinal chemistry letters, 03-01, Volume: 27, Issue:5 | Methylsulfonyl benzothiazoles (MSBT) derivatives: Search for new potential antimicrobial and anticancer agents. |
| AID530961 | Antifungal activity against Candida parapsilosis ATCC 22019 after 48 hrs by CLSI method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Potent in vitro antifungal activities of naturally occurring acetylenic acids. |
| AID555572 | Antimicrobial activity against Candida lusitaniae by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Activity profile in vitro of micafungin against Spanish clinical isolates of common and emerging species of yeasts and molds. |
| AID555589 | Antimicrobial activity against Cryptococcus neoformans var. neoformans by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Activity profile in vitro of micafungin against Spanish clinical isolates of common and emerging species of yeasts and molds. |
| AID1198409 | Anticandidal activity against Candida albicans ATCC 90028 incubated at 37 degC for 24 hrs by broth dilution method | 2015 | European journal of medicinal chemistry, Mar-26, Volume: 93 | Synthesis, QSAR and anticandidal evaluation of 1,2,3-triazoles derived from naturally bioactive scaffolds. |
| AID1498762 | Antifungal activity against Candida albicans after 24 hrs by two fold serial dilution based spectrophotometric analysis | 2018 | Bioorganic & medicinal chemistry letters, 08-01, Volume: 28, Issue:14 | Azoalkyl ether imidazo[2,1-b]benzothiazoles as potentially antimicrobial agents with novel structural skeleton. |
| AID1303302 | Antimicrobial activity against Candida mycoderma ATCC 9888 after 24 hrs by microbroth dilution method | 2016 | Bioorganic & medicinal chemistry letters, 06-01, Volume: 26, Issue:11 | Design, synthesis and biological evaluation of 5-fluorouracil-derived benzimidazoles as novel type of potential antimicrobial agents. |
| AID457979 | Antifungal activity against Candida albicans ATCC 90028 after 24 hrs by microdilution method | 2010 | Bioorganic & medicinal chemistry, Mar-01, Volume: 18, Issue:5 | Antifungal 3,5-disubstituted furanones: From 5-acyloxymethyl to 5-alkylidene derivatives. |
| AID574611 | Antifungal activity against Candida glabrata 20/I after 48 hrs by broth microdilution method | 2011 | Bioorganic & medicinal chemistry, Feb-15, Volume: 19, Issue:4 | Synthesis and antimycobacterial properties of N-substituted 6-amino-5-cyanopyrazine-2-carboxamides. |
| AID1890274 | Antifungal activity against Microsporum gypseum clinical isolate 1 assessed as reduction in fungal growth by broth dilution method | 2022 | Bioorganic & medicinal chemistry letters, 05-01, Volume: 63 | Novel 2-aryl-4-aryloxyquinoline-based fungistatics for Mucor circinelloides. Biological evaluation of activity, QSAR and docking study. |
| AID521511 | Antifungal activity against Aspergillus fumigatus IFM 49895 after 48 hrs by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | In vitro and in vivo antifungal activities of T-2307, a novel arylamidine. |
| AID382539 | Antifungal activity against Cryptococcus neoformans SYM 523 after 48 hrs standard broth microdilution method | 2008 | European journal of medicinal chemistry, Jan, Volume: 43, Issue:1 | Synthesis, structure and biological activity of pseudopeptidic macrolides based on an amino alcohol. |
| AID518142 | Antimicrobial activity against Cryptococcus gattii serotype B isolate RB-8 assessed as concentration required for heteroresistance | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Heteroresistance of Cryptococcus gattii to fluconazole. |
| AID1634360 | Antifungal activity against Candida tropicalis cgmcc 2.3739 assessed as inhibition of visible microbe growth by broth microdilution method | 2019 | Bioorganic & medicinal chemistry letters, 09-01, Volume: 29, Issue:17 | Design, synthesis and evaluation of biphenyl imidazole analogues as potent antifungal agents. |
| AID521789 | Antifungal activity against 1.04 x 10'8 CFU fluconazole-susceptible Candida glabrata isolate 4293 infected neutropenic CD1 mouse disseminated candidiasis model assessed as reduction in kidney tissue fungal burden at 25 mg/kg/day, ip administered 24 hrs po | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Posaconazole against Candida glabrata isolates with various susceptibilities to fluconazole. |
| AID1592214 | Antifungal activity against Candida albicans ATCC 10231 assessed as inhibition of microbial growth by NCCLS protocol based method | 2019 | Bioorganic & medicinal chemistry, 06-15, Volume: 27, Issue:12 | Design, synthesis and biological evaluation of amide-pyridine derivatives as novel dual-target (SE, CYP51) antifungal inhibitors. |
| AID1246580 | Antifungal activity against Cryptococcus gattii 135L/03 after 48 to 72 hrs by broth microdilution method | 2015 | European journal of medicinal chemistry, Sep-18, Volume: 102 | Thiazole compounds with activity against Cryptococcus gattii and Cryptococcus neoformans in vitro. |
| AID619173 | Antifungal activity against Candida glabrata CG 7 by broth dilution method | 2011 | Journal of medicinal chemistry, Oct-13, Volume: 54, Issue:19 | High-throughput-screening-based identification and structure-activity relationship characterization defined (S)-2-(1-aminoisobutyl)-1-(3-chlorobenzyl)benzimidazole as a highly antimycotic agent nontoxic to cell lines. |
| AID555570 | Antimicrobial activity against Candida krusei by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Activity profile in vitro of micafungin against Spanish clinical isolates of common and emerging species of yeasts and molds. |
| AID1246727 | Antifungal activity against Cryptococcus gattii L27/01 assessed as reduction in ergosterol content at MIC after 24 hrs by spectrophotometric analysis | 2015 | European journal of medicinal chemistry, Sep-18, Volume: 102 | Thiazole compounds with activity against Cryptococcus gattii and Cryptococcus neoformans in vitro. |
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| AID1480834 | Anti-fungal activity against drug-resistant Candida glabrata after 48 hrs by broth microdilution method | 2017 | European journal of medicinal chemistry, Apr-21, Volume: 130 | New azole derivatives showing antimicrobial effects and their mechanism of antifungal activity by molecular modeling studies. |
| AID526822 | Antifungal activity against FLCZ-susceptible Candida albicans ATCC 90028 assessed as concentration required to 80% growth inhibition using alamar blue staining after 18 to 72 hrs by microdilution method | 2010 | Bioorganic & medicinal chemistry, Nov-01, Volume: 18, Issue:21 | 1,3-Benzoxazole-4-carbonitrile as a novel antifungal scaffold of β-1,6-glucan synthesis inhibitors. |
| AID714931 | Antimicrobial activity against Aspergillus flavus NCIM 524 at 10 ug/disc incubated for 48 hrs by agar disc diffusion method | 2012 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 22, Issue:23 | Synthesis, characterization, antidepressant and antioxidant activity of novel piperamides bearing piperidine and piperazine analogues. |
| AID555601 | Antimicrobial activity against Trichosporon mycotoxinivorans by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Activity profile in vitro of micafungin against Spanish clinical isolates of common and emerging species of yeasts and molds. |
| AID1818288 | Inhibition of SE/CYP51 in Candida albicans ATCC SC5314 assessed as squalene level incubated for 48 hrs by LC/MS analysis | |||
| AID371232 | Antimicrobial activity against Candida krusei ATCC 6258 by broth microdilution method | 2008 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 18, Issue:24 | Carbon analogs of antifungal dioxane-triazole derivatives: synthesis and in vitro activities. |
| AID287832 | Antifungal activity against Absidia corymbifera 272 after 48 hrs | 2007 | Bioorganic & medicinal chemistry, Apr-15, Volume: 15, Issue:8 | Hybrid molecules of estrone: new compounds with potential antibacterial, antifungal, and antiproliferative activities. |
| AID544872 | Antimicrobial activity against Candida albicans harboring P639S mutation in MRR1F5 gene by microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | Gain-of-function mutations in the transcription factor MRR1 are responsible for overexpression of the MDR1 efflux pump in fluconazole-resistant Candida dubliniensis strains. |
| AID637211 | Antifungal activity against Candida albicans MTCC 227 after 48 hrs by tube dilution method | 2012 | European journal of medicinal chemistry, Feb, Volume: 48 | Synthesis, antimicrobial, anticancer evaluation and QSAR studies of 6-methyl-4-[1-(2-substituted-phenylamino-acetyl)-1H-indol-3-yl]-2-oxo/thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid ethyl esters. |
| AID1154816 | Antifungal activity against Cryptococcus neoformans 32609 after 72 hrs by serial dilution method | 2014 | ACS medicinal chemistry letters, May-08, Volume: 5, Issue:5 | Novel carboline derivatives as potent antifungal lead compounds: design, synthesis, and biological evaluation. |
| AID420075 | Antifungal activity against Candida parapsilosis after 48 hrs by broth microdilution assay | 2009 | Bioorganic & medicinal chemistry, Jun-01, Volume: 17, Issue:11 | Bulky 1,4-benzoxazine derivatives with antifungal activity. |
| AID519687 | Antimicrobial activity against Saccharomyces cerevisiae containing disruption in YKL037W gene by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Genomewide screening for genes associated with gliotoxin resistance and sensitivity in Saccharomyces cerevisiae. |
| AID1556217 | Inhibition of CYP51 in Candida albicans ATCC SC5314 assessed as ergosterol level at 2 ug/ml incubated for 16 hrs by GC/MS analysis (Rvb = 100%) | 2019 | European journal of medicinal chemistry, Sep-01, Volume: 177 | Design, synthesis, and structure-activity relationship studies of l-amino alcohol derivatives as broad-spectrum antifungal agents. |
| AID1886033 | Synergistic antifungal activity against Candida auris CBS 12372 assessed as fractional inhibitory concentration index incubated for 48 hrs in presence of P163-0892 by broth microdilution method | |||
| AID434364 | Antifungal activity against Aspergillus fumigatus after 72 hrs by broth microdilution method | 2009 | European journal of medicinal chemistry, Aug, Volume: 44, Issue:8 | Design, synthesis and biological evaluation of novel nitrogen and sulfur containing hetero-1,4-naphthoquinones as potent antifungal and antibacterial agents. |
| AID655717 | Antifungal activity against Curvularia lunata MTCC 581 at 20 uM/ml after 48 hrs by paper disc diffusion method | 2012 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 22, Issue:8 | Design, synthesis, synergistic antimicrobial activity and cytotoxicity of 4-aryl substituted 3,4-dihydropyrimidinones of curcumin. |
| AID1067047 | Antifungal activity against Cryptococcus neoformans after 72 hrs by micro-broth dilution method | 2014 | European journal of medicinal chemistry, Mar-03, Volume: 74 | Synthesis, antifungal activities and molecular docking studies of novel 2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propyl dithiocarbamates. |
| AID1918333 | Antifungal activity against Cryptococcus neoformans assessed as inhibition of fungal growth measured after 72 hrs by CLSI based liquid medium dilution method | 2022 | Journal of medicinal chemistry, 11-10, Volume: 65, Issue:21 | Novel Aryl Alkamidazole Derivatives as Multifunctional Antifungal Inhibitors: Design, Synthesis, and Biological Evaluation. |
| AID519513 | Antifungal activity against Candida tropicalis isolates after 48 hrs by CLSI M27-A2 procedure based assay | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | In vitro antifungal activities of isavuconazole (BAL4815), voriconazole, and fluconazole against 1,007 isolates of zygomycete, Candida, Aspergillus, Fusarium, and Scedosporium species. |
| AID1898155 | Antifungal activity against Cryptococcus neoformans 32605 | |||
| AID1898165 | Antifungal activity against Candida albicans 28# | |||
| AID47866 | Evaluation of In vitro antifungal activity against Candida parapsilosis ATCC 22019 by broth macro dilution method | 1995 | Journal of medicinal chemistry, Sep-29, Volume: 38, Issue:20 | Synthesis and antifungal activity of new azole derivatives containing an N-acylmorpholine ring. |
| AID619178 | Antifungal activity against Candida albicans Jg 32570 by broth dilution method | 2011 | Journal of medicinal chemistry, Oct-13, Volume: 54, Issue:19 | High-throughput-screening-based identification and structure-activity relationship characterization defined (S)-2-(1-aminoisobutyl)-1-(3-chlorobenzyl)benzimidazole as a highly antimycotic agent nontoxic to cell lines. |
| AID1435669 | Antifungal activity against Trichophyton mentagrophytes 445 after 72 hrs by broth microdilution method | 2017 | European journal of medicinal chemistry, Jan-27, Volume: 126 | S-substituted 3,5-dinitrophenyl 1,3,4-oxadiazole-2-thiols and tetrazole-5-thiols as highly efficient antitubercular agents. |
| AID1911618 | Antifungal activity against Candida albicans SC5314 assessed as fungal growth inhibition by broth microdilution assay | 2022 | Journal of medicinal chemistry, 06-09, Volume: 65, Issue:11 | Development of Lipo-γ-AA Peptides as Potent Antifungal Agents. |
| AID1474173 | Antifungal activity against fluconazole-resistant Candida albicans 100 by broth microdilution assay | 2016 | European journal of medicinal chemistry, Nov-10, Volume: 123 | Design, synthesis, and structure-activity relationship studies of benzothiazole derivatives as antifungal agents. |
| AID1602387 | Antifungal activity against Cryptococcus neoformans H99 assessed as cell wall collapse at 4 ug/ml after 24 hrs by TEM analysis | 2019 | Journal of medicinal chemistry, 03-14, Volume: 62, Issue:5 | Discovery of Carboline Derivatives as Potent Antifungal Agents for the Treatment of Cryptococcal Meningitis. |
| AID340962 | Antifungal activity against sCandida stellata isolates from grapes by NCCLS M27-A2 method | 2007 | Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8 | Cross-resistance to medical and agricultural azole drugs in yeasts from the oropharynx of human immunodeficiency virus patients and from environmental Bavarian vine grapes. |
| AID1419537 | Hemolytic activity in mouse erythrocytes assessed as hemolysis level at 62.5 ug/ml incubated for 1 hr at 37 degC | 2017 | European journal of medicinal chemistry, Jun-16, Volume: 133 | Novel alkylated azoles as potent antifungals. |
| AID594995 | Antifungal activity against Candida albicans after 48 hrs by Halo zone test | 2011 | Bioorganic & medicinal chemistry letters, May-15, Volume: 21, Issue:10 | Thermal solvent-free synthesis of novel pyrazolyl chalcones and pyrazolines as potential antimicrobial agents. |
| AID1287099 | Antimicrobial activity against Candida albicans ATCC 2002 assessed as inhibition of bacterial growth after 16 hrs by broth dilution method | 2016 | Journal of medicinal chemistry, Mar-10, Volume: 59, Issue:5 | A Designed Tryptophan- and Lysine/Arginine-Rich Antimicrobial Peptide with Therapeutic Potential for Clinical Antibiotic-Resistant Candida albicans Vaginitis. |
| AID1272747 | Antifungal activity against Aspergillus niger at 0.13 mol/L after 2 to 4 days by paper disc method | 2016 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 26, Issue:3 | Synthesis, antimicrobial activity of Schiff base compounds of cinnamaldehyde and amino acids. |
| AID1392814 | Inhibition of Cyp51 in Candida albicans ATCC SC5314 assessed as ergosterol content at 0.5 ug/ml after 16 hrs by GC-MS analysis (Rvb = 98.7%) | 2018 | Bioorganic & medicinal chemistry, 07-23, Volume: 26, Issue:12 | Design, synthesis and evaluation of benzoheterocycle analogues as potent antifungal agents targeting CYP51. |
| AID521508 | Antifungal activity against Aspergillus flavus NBRC 6343 after 48 hrs by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | In vitro and in vivo antifungal activities of T-2307, a novel arylamidine. |
| AID1911627 | Antifungal activity against Aspergillus fumigatus shjt40 assessed as fungal growth inhibition by broth microdilution assay | 2022 | Journal of medicinal chemistry, 06-09, Volume: 65, Issue:11 | Development of Lipo-γ-AA Peptides as Potent Antifungal Agents. |
| AID470599 | Antifungal activity against Trichophyton mentagrophytes after 96 hrs by microbroth dilution technique | 2009 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 19, Issue:18 | Design and synthesis of bile acid-based amino sterols as antimicrobial agents. |
| AID584411 | Antifungal activity against 2 days cultured Candida tropicalis isolated from neutropenic subject with AML or MDS stool receiving antifungal therapy for 45 days after 24 days of prophylaxis by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Impact of antifungal prophylaxis on colonization and azole susceptibility of Candida species. |
| AID644833 | Antifungal activity against Candida sp. after 48 hrs by M27-A3 CLSI method | 2012 | European journal of medicinal chemistry, Mar, Volume: 49 | Synthesis and antifungal activity of a new series of 2-(1H-imidazol-1-yl)-1-phenylethanol derivatives. |
| AID1465987 | Antifungal activity against Aspergillus niger ATCC 6275 after 68 hrs by broth dilution assay | 2017 | Bioorganic & medicinal chemistry, 06-01, Volume: 25, Issue:11 | Investigation of aryl isonitrile compounds with potent, broad-spectrum antifungal activity. |
| AID42869 | Inhibition of Candida glabrata 20/I growth for 48 hours in vitro. | 2001 | Journal of medicinal chemistry, Aug-16, Volume: 44, Issue:17 | 3-Phenyl-5-acyloxymethyl-2H,5H-furan-2-ones: synthesis and biological activity of a novel group of potential antifungal drugs. |
| AID1484687 | Leishmanicidal activity against Leishmania panamensis L334 promastigotes forms after 18 hrs by indirect microscopic analysis | 2017 | European journal of medicinal chemistry, Jul-28, Volume: 135 | An overview of azoles targeting sterol 14α-demethylase for antileishmanial therapy. |
| AID565398 | Antifungal activity against Rhizopus microsporus CBS 102277 by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Correlation of in vitro activity, serum levels, and in vivo efficacy of posaconazole against Rhizopus microsporus in a murine disseminated infection. |
| AID1754371 | Antifungal activity against Trichophyton interdigitale ATCC 9533 assessed as reduction in fungal growth incubated for 120 hrs by broth microdilution method based spectrophotometric analysis | 2021 | Bioorganic & medicinal chemistry, 07-01, Volume: 41 | Iodinated 1,2-diacylhydrazines, benzohydrazide-hydrazones and their analogues as dual antimicrobial and cytotoxic agents. |
| AID1369460 | Fungicidal activity against Candida albicans SP3876 after 96 hrs | 2018 | Journal of medicinal chemistry, 05-10, Volume: 61, Issue:9 | Combating Drug-Resistant Fungi with Novel Imperfectly Amphipathic Palindromic Peptides. |
| AID392374 | Antifungal activity against Absidia corymbifera 272 after 48 hrs by broth microdilution method | 2009 | Bioorganic & medicinal chemistry letters, Jan-15, Volume: 19, Issue:2 | Salicylanilide esters of N-protected amino acids as novel antimicrobial agents. |
| AID424659 | Antimicrobial activity against azole-resistant Candida albicans isolate CA10 assessed as growth at 128 ug/ml co-treated with 0.063 ug/ml calcineurin signaling inhibitor tacrolimus after 48 hrs by microdilution checkboard technique relative to control | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | In vitro interactions between tacrolimus and azoles against Candida albicans determined by different methods. |
| AID602927 | Antifungal activity against Candida albicans Y0109 after 24 hrs by micro-broth dilution method | 2011 | European journal of medicinal chemistry, Jul, Volume: 46, Issue:7 | Design, synthesis and antifungal evaluation of 1-(2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propyl)-1H-1,2,4-triazol-5(4H)-one. |
| AID1494154 | Antifungal activity against Candida tropicalis after 24 hrs | 2018 | European journal of medicinal chemistry, Jan-01, Volume: 143 | Molecular docking, design, synthesis and antifungal activity study of novel triazole derivatives. |
| AID518887 | Antimicrobial activity against Cryptococcus gattii serotype C isolate NIH18 assessed as heteroresistant isolates at 32 ug/ml | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Heteroresistance of Cryptococcus gattii to fluconazole. |
| AID554950 | Inhibition of Candida krusei B2399 Abc1p assessed as fractional inhibitory concentration index at 2.5 ug/ml after 48 hrs by checkerboard susceptibility assay | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Abc1p is a multidrug efflux transporter that tips the balance in favor of innate azole resistance in Candida krusei. |
| AID622961 | Antifungal activity against Candida albicans ATCC 90028 after 24 hrs by microdilution method | 2011 | Bioorganic & medicinal chemistry letters, Oct-15, Volume: 21, Issue:20 | Synthesis and biological activity of desmethoxy analogues of coruscanone A. |
| AID1157162 | Antifungal activity against Candida glabrata PMC 0807 after 48 hrs by CLSI broth microdilution method | 2014 | European journal of medicinal chemistry, Aug-18, Volume: 83 | Synthesis, biological evaluation and structure-activity correlation study of a series of imidazol-based compounds as Candida albicans inhibitors. |
| AID581894 | Antifungal activity against Candida albicans isolated from HSCT recipient 928 with acute or chronic GVHD mouth after 112 days prophylaxis by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Impact of antifungal prophylaxis on colonization and azole susceptibility of Candida species. |
| AID566887 | Antifungal activity against Aspergillus terreus by microdilution test | 2011 | European journal of medicinal chemistry, Jan, Volume: 46, Issue:1 | Synthesis and antifungal activity of some substituted phenothiazines and related compounds. |
| AID1391606 | Antifungal activity against Candida albicans SC5314 after 48 hrs by broth microdilution method | 2018 | Bioorganic & medicinal chemistry letters, 05-15, Volume: 28, Issue:9 | Diversity-oriented synthesis of pyrazoles derivatives from flavones and isoflavones leads to the discovery of promising reversal agents of fluconazole resistance in Candida albicans. |
| AID1743168 | Antifungal activity against Trichophyton tonsurans | 2020 | European journal of medicinal chemistry, Dec-15, Volume: 208 | Multiple biological active 4-aminopyrazoles containing trifluoromethyl and their 4-nitroso-precursors: Synthesis and evaluation. |
| AID1435663 | Antifungal activity against Trichosporon asahii 1188 after 24 hrs by broth microdilution method | 2017 | European journal of medicinal chemistry, Jan-27, Volume: 126 | S-substituted 3,5-dinitrophenyl 1,3,4-oxadiazole-2-thiols and tetrazole-5-thiols as highly efficient antitubercular agents. |
| AID424648 | Antimicrobial activity against azole-resistant Candida albicans isolate CA10 assessed as growth at 128 ug/ml cotreated with 0.125 ug/ml calcineurin signaling inhibitor Tacrolimus after 48 hrs by microdilution checkboard technique relative to control | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | In vitro interactions between tacrolimus and azoles against Candida albicans determined by different methods. |
| AID555595 | Antimicrobial activity against Trichosporon jirovecii by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Activity profile in vitro of micafungin against Spanish clinical isolates of common and emerging species of yeasts and molds. |
| AID1885960 | Antifungal activity against Cryptococcus neoformans clinical isolate BJ3 assessed as fungal growth inhibition incubated for 72 hrs by broth microdilution method | |||
| AID1265819 | Antifungal activity against azole-resistant Candida albicans MYA-1237 after 48 hrs by microbroth dilution method | 2015 | Journal of medicinal chemistry, Dec-10, Volume: 58, Issue:23 | Synthesis and Bioactivities of Kanamycin B-Derived Cationic Amphiphiles. |
| AID1707464 | Antifungal activity against Candida albicans 0304103 incubated for 48 hrs by microdilution assay | 2021 | Journal of medicinal chemistry, 01-28, Volume: 64, Issue:2 | Novel Carboline Fungal Histone Deacetylase (HDAC) Inhibitors for Combinational Treatment of Azole-Resistant Candidiasis. |
| AID1728518 | Inhibition of CYP51 in Candida albicans ATCC SC5314 assessed as unknown sterol level at 0.125 ug/ml incubated for 48 hrs by LC/MS analysis | 2021 | European journal of medicinal chemistry, Jan-15, Volume: 210 | Novel naphthylamide derivatives as dual-target antifungal inhibitors: Design, synthesis and biological evaluation. |
| AID1758037 | Inhibition of CYP51 in Candida albicans ATCC SC5314 assessed as lanosterol level at 0.125 ug/ml after 16 hrs by GC-MS analysis (Rvb = 1.7%) | 2021 | European journal of medicinal chemistry, Apr-15, Volume: 216 | Lead optimization generates selenium-containing miconazole CYP51 inhibitors with improved pharmacological profile for the treatment of fungal infections. |
| AID1335846 | Antifungal activity against Aspergillus flavus after 24 hrs by two fold serial dilution method | 2016 | European journal of medicinal chemistry, Nov-29, Volume: 124 | Multi-targeting exploration of new 2-aminothiazolyl quinolones: Synthesis, antimicrobial evaluation, interaction with DNA, combination with topoisomerase IV and penetrability into cells. |
| AID1783775 | Antifungal activity against Candida albicans GIM2.194 assessed as inhibition of fungal growth by NCCLS protocol based method | 2021 | European journal of medicinal chemistry, Nov-15, Volume: 224 | Improving the metabolic stability of antifungal compounds based on a scaffold hopping strategy: Design, synthesis, and structure-activity relationship studies of dihydrooxazole derivatives. |
| AID407009 | Antimicrobial activity against fluconazole-resistant Candida albicans FH5 at planktonic cell density of 10'8 cells/ml after 48 hrs by XTT assay | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | Role for cell density in antifungal drug resistance in Candida albicans biofilms. |
| AID1543306 | Antimicrobial activity against Pseudomonas aeruginosa ATCC 27853 assessed as inhibition of microbial growth by CLSI based method | 2019 | Journal of natural products, 07-26, Volume: 82, Issue:7 | Anthraquinone-Based Specialized Metabolites from Rhizomes of |
| AID424640 | Antimicrobial activity against azole-resistant Candida albicans isolate CA10 assessed as growth at 0.5 ug/ml co-treated with 0.125 ug/ml calcineurin signaling inhibitor tacrolimus after 48 hrs by microdilution checkboard technique relative to control | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | In vitro interactions between tacrolimus and azoles against Candida albicans determined by different methods. |
| AID516258 | Antimicrobial activity against Cryptococcus gattii serotype B isolate NIH444 assessed as concentration required for heteroresistance | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Heteroresistance of Cryptococcus gattii to fluconazole. |
| AID1401695 | Antifungal against Candida utilis after 24 hrs by two fold serial dilution method | 2018 | European journal of medicinal chemistry, Jan-01, Volume: 143 | Novel aminopyrimidinyl benzimidazoles as potentially antimicrobial agents: Design, synthesis and biological evaluation. |
| AID367168 | Cytotoxicity against human A431 cells at 1 mg/ml | 2009 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 19, Issue:3 | Synthesis and antifungal activity of 1,2,3-triazole containing fluconazole analogues. |
| AID462259 | Antifungal activity against pharmacoresistant Candida albicans AIDS68 infected in Wistar rat estrogen-dependent fungal vaginitis model assessed as fungal burden at 10 ug administered intravaginally 48 hrs after fungal infection measured on day 21 after in | 2010 | Journal of medicinal chemistry, Mar-25, Volume: 53, Issue:6 | Identification of inhibitors of drug-resistant Candida albicans strains from a library of bicyclic peptidomimetic compounds. |
| AID42676 | In vitro minimum inhibitory concentration against Candida albicans. | 2001 | Journal of medicinal chemistry, May-24, Volume: 44, Issue:11 | Diguanidino and "reversed" diamidino 2,5-diarylfurans as antimicrobial agents. |
| AID323074 | Antifungal activity against Cryptococcus neoformans IM 031706 by micro-broth dilution method | 2008 | Bioorganic & medicinal chemistry, Jan-15, Volume: 16, Issue:2 | Antifungal and cytotoxic activities of some N-substituted aniline derivatives bearing a hetaryl fragment. |
| AID425141 | Antimicrobial activity against azole-resistant Candida albicans isolate CA10 assessed as growth at 2 ug/ml after 48 hrs by microdilution checkerboard technique relative to control | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | In vitro interactions between tacrolimus and azoles against Candida albicans determined by different methods. |
| AID47217 | Antifungal activity expressed as inhibitory concentration against Candida albicans CY1002 in calf serum | 2002 | Bioorganic & medicinal chemistry letters, Feb-25, Volume: 12, Issue:4 | Design and synthesis of novel benzofurans as a new class of antifungal agents targeting fungal N-myristoyltransferase. Part 2. |
| AID1415615 | Antifungal activity against fluconazole-resistant Candida tropicalis clinical isolate 087 by broth microdilution method | 2017 | MedChemComm, May-01, Volume: 8, Issue:5 | Synthesis and synergistic antifungal effects of monoketone derivatives of curcumin against fluconazole-resistant |
| AID440343 | Antifungal activity against Aspergillus niger NCIM 617 at 10 ug/ml after 2 to 3 days by serial plate dilution method | 2009 | European journal of medicinal chemistry, Dec, Volume: 44, Issue:12 | Synthesis and antimicrobial activity of some new N-acyl substituted phenothiazines. |
| AID1546131 | Antibacterial activity against methicillin resistant Staphylococcus aureus N315 after 24 hrs by two-fold broth serial dilution method | 2019 | European journal of medicinal chemistry, Dec-15, Volume: 184 | Current scenario of tetrazole hybrids for antibacterial activity. |
| AID1480833 | Anti-fungal activity against Candida parapsilosis ATCC 90018 after 48 hrs by broth microdilution method | 2017 | European journal of medicinal chemistry, Apr-21, Volume: 130 | New azole derivatives showing antimicrobial effects and their mechanism of antifungal activity by molecular modeling studies. |
| AID454195 | Antifungal activity against Candida albicans NCIM 347 by standard agar plate method | 2010 | Bioorganic & medicinal chemistry letters, Jan-15, Volume: 20, Issue:2 | One pot synthesis and SAR of some novel 3-substituted 5,6-diphenyl-1,2,4-triazines as antifungal agents. |
| AID279104 | Mortality rate in Candida tropicalis infected candidemia patient | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Association of fluconazole area under the concentration-time curve/MIC and dose/MIC ratios with mortality in nonneutropenic patients with candidemia. |
| AID530964 | Antifungal activity against Fluconazole resistant Candida albicans clinical isolate 17 after 48 hrs by CLSI method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Potent in vitro antifungal activities of naturally occurring acetylenic acids. |
| AID518690 | Antimicrobial activity against Cryptococcus gattii serotype B isolate NIH286 assessed as heteroresistant isolates at 16 ug/ml | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Heteroresistance of Cryptococcus gattii to fluconazole. |
| AID719317 | Antimicrobial activity against Staphylococcus aureus NCIM 5021 by broth dilution method | 2012 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 22, Issue:23 | Synthesis, characterization, antidepressant and antioxidant activity of novel piperamides bearing piperidine and piperazine analogues. |
| AID1392805 | Antifungal activity against fluconazole-resistant Candida albicans strain 100 after 24 hrs by serial dilution method | 2018 | Bioorganic & medicinal chemistry, 07-23, Volume: 26, Issue:12 | Design, synthesis and evaluation of benzoheterocycle analogues as potent antifungal agents targeting CYP51. |
| AID424915 | Antimicrobial activity against azole-resistant Candida albicans isolate CA10 assessed as growth at 4 ug/ml cotreated with 0.004 ug/ml calcineurin signaling inhibitor tacrolimus after 48 hrs by microdilution checkerboard technique relative to control | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | In vitro interactions between tacrolimus and azoles against Candida albicans determined by different methods. |
| AID540212 | Mean residence time in human after iv administration | 2008 | Drug metabolism and disposition: the biological fate of chemicals, Jul, Volume: 36, Issue:7 | Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. |
| AID545276 | Antifungal activity against Aspergillus fumigatus 231 after 24 hrs by broth microdilution method | 2010 | European journal of medicinal chemistry, Dec, Volume: 45, Issue:12 | New amino acid esters of salicylanilides active against MDR-TB and other microbes. |
| AID1157171 | Antifungal activity against Trichophyton mentagrophytes DSM 4870 after 72 hrs by CLSI broth microdilution method | 2014 | European journal of medicinal chemistry, Aug-18, Volume: 83 | Synthesis, biological evaluation and structure-activity correlation study of a series of imidazol-based compounds as Candida albicans inhibitors. |
| AID567433 | Antifungal activity against Saccharomyces cerevisiae after 48 hrs by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | In vitro antifungal activities of isavuconazole and comparators against rare yeast pathogens. |
| AID300442 | Antifungal activity against Candida parapsilosis ATCC 22019 after 48 hrs by broth microdilution test | 2007 | Bioorganic & medicinal chemistry, Sep-01, Volume: 15, Issue:17 | 1-Acylthiosemicarbazides, 1,2,4-triazole-5(4H)-thiones, 1,3,4-thiadiazoles and hydrazones containing 5-methyl-2-benzoxazolinones: synthesis, analgesic-anti-inflammatory and antimicrobial activities. |
| AID424885 | Antimicrobial activity against azole-resistant Candida albicans isolate CA10 assessed as growth at 32 ug/ml co-treated with 0.031 ug/ml calcineurin signaling inhibitor tacrolimus after 48 hrs by microdilution checkboard technique relative to control | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | In vitro interactions between tacrolimus and azoles against Candida albicans determined by different methods. |
| AID526820 | Solubility in water at pH 6.8 | 2010 | Bioorganic & medicinal chemistry, Nov-01, Volume: 18, Issue:21 | 1,3-Benzoxazole-4-carbonitrile as a novel antifungal scaffold of β-1,6-glucan synthesis inhibitors. |
| AID555573 | Antimicrobial activity against Candida kefyr by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Activity profile in vitro of micafungin against Spanish clinical isolates of common and emerging species of yeasts and molds. |
| AID672345 | Antifungal activity against Cryptococcus neoformans KCCM 50564 after 1 day | 2012 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 22, Issue:15 | Synthesis, antitubercular and antimicrobial evaluation of 3-(4-chlorophenyl)-4-substituted pyrazole derivatives. |
| AID276391 | Antifungal activity against Sporothrix schenckii by broth microdilution technique | 2006 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 16, Issue:22 | Naphtho[2,3-b][1,4]-thiazine-5,10-diones and 3-substituted-1,4-dioxo-1,4-dihydronaphthalen-2-yl-thioalkanoate derivatives: synthesis and biological evaluation as potential antibacterial and antifungal agents. |
| AID1911660 | Antifungal activity against Candida albicans CARG5 infected in BALB/c mouse surgical wound model assessed as reduction in fungal burden smeared on wound at 8 mg/kg administered every 12 hrs for 48 hrs | 2022 | Journal of medicinal chemistry, 06-09, Volume: 65, Issue:11 | Development of Lipo-γ-AA Peptides as Potent Antifungal Agents. |
| AID1484684 | Leishmanicidal activity against Leishmania mexicana 68 promastigote forms after 18 hrs by indirect microscopic analysis | 2017 | European journal of medicinal chemistry, Jul-28, Volume: 135 | An overview of azoles targeting sterol 14α-demethylase for antileishmanial therapy. |
| AID469172 | Antifungal activity against Candida tropicalis at MIC after 72 hrs by disk diffusion assay | 2010 | European journal of medicinal chemistry, Feb, Volume: 45, Issue:2 | Synthesis, anti-bacterial and anti-fungal activities of some novel Schiff bases containing 2,4-disubstituted thiazole ring. |
| AID734684 | Antifungal activity against Candida albicans MTCC 3017 at 20 ug/ml after 24 hrs by disk diffusion method | 2013 | European journal of medicinal chemistry, Apr, Volume: 62 | Synthesis, biological evaluation of new oxazolidino-sulfonamides as potential antimicrobial agents. |
| AID1392828 | Inhibition of Cyp51 in Candida albicans ATCC SC5314 assessed as eburicol content at 2 ug/ml after 16 hrs by GC-MS analysis (Rvb = 0.4%) | 2018 | Bioorganic & medicinal chemistry, 07-23, Volume: 26, Issue:12 | Design, synthesis and evaluation of benzoheterocycle analogues as potent antifungal agents targeting CYP51. |
| AID1465980 | Antifungal activity against Candida glabrata ATCC 66032 after 44 hrs by broth dilution assay | 2017 | Bioorganic & medicinal chemistry, 06-01, Volume: 25, Issue:11 | Investigation of aryl isonitrile compounds with potent, broad-spectrum antifungal activity. |
| AID1628389 | Antimicrobial activity against Candida utilis ATCC 9950 incubated for 24 hrs by NCCLS protocol based method | 2016 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 26, Issue:12 | Discovery of novel berberine imidazoles as safe antimicrobial agents by down regulating ROS generation. |
| AID352320 | Antifungal activity against Candida albicans at 37 degC after 48 hrs by tube dilution method | 2009 | European journal of medicinal chemistry, Mar, Volume: 44, Issue:3 | Synthesis and QSAR evaluation of 2-(substituted phenyl)-1H-benzimidazoles and [2-(substituted phenyl)-benzimidazol-1-yl]-pyridin-3-yl-methanones. |
| AID416943 | Antifungal activity against Cryptococcus neoformans by broth microdilution test | 2009 | Bioorganic & medicinal chemistry, Mar-15, Volume: 17, Issue:6 | Exploration of click reaction for the synthesis of modified nucleosides as chitin synthase inhibitors. |
| AID531235 | Antifungal activity against Candida glabrata after 48 hrs by CLSI method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | In vitro susceptibilities of invasive isolates of Candida species: rapid increase in rates of fluconazole susceptible-dose dependent Candida glabrata isolates. |
| AID1246673 | Antifungal activity against Cryptococcus neoformans CN31 assessed as reduction in cell viability at 26 uM after 6 to 72 hrs by MTT assay | 2015 | European journal of medicinal chemistry, Sep-18, Volume: 102 | Thiazole compounds with activity against Cryptococcus gattii and Cryptococcus neoformans in vitro. |
| AID1818293 | Inhibition of CYP51 in Candida albicans ATCC SC5314 measured after 30 mins by HPLC analysis | |||
| AID39695 | In vitro antifungal activity against Aspergillus fumigatus | 2003 | Journal of medicinal chemistry, Feb-13, Volume: 46, Issue:4 | Structure-based de novo design, synthesis, and biological evaluation of non-azole inhibitors specific for lanosterol 14alpha-demethylase of fungi. |
| AID1271236 | Antifungal activity against Candida albicans ATCC 10231 after 72 hrs by broth microdilution method | 2015 | ACS medicinal chemistry letters, Nov-12, Volume: 6, Issue:11 | Silicon Incorporated Morpholine Antifungals: Design, Synthesis, and Biological Evaluation. |
| AID549053 | Antifungal activity against Candida albicans CA138 after 48 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | In vitro activities of retigeric acid B alone and in combination with azole antifungal agents against Candida albicans. |
| AID625282 | Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for cirrhosis | 2011 | PLoS computational biology, Dec, Volume: 7, Issue:12 | Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). |
| AID1271241 | Antifungal activity against Candida tropicalis ATCC 750 after 24 to 36 hrs by broth microdilution method | 2015 | ACS medicinal chemistry letters, Nov-12, Volume: 6, Issue:11 | Silicon Incorporated Morpholine Antifungals: Design, Synthesis, and Biological Evaluation. |
| AID395837 | Antimicrobial activity against Sporothrix schenckii after 72 hrs by standard microbroth dilution assay | 2009 | European journal of medicinal chemistry, Jan, Volume: 44, Issue:1 | Tetrahydronaphthyl azole oxime ethers: the conformationally rigid analogues of oxiconazole as antibacterials. |
| AID532557 | Antifungal activity against Saccharomyces cerevisiae BY4741 assessed as growth rate at 16 ug/ml (Rvb = 0.144%) | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | Differential azole antifungal efficacies contrasted using a Saccharomyces cerevisiae strain humanized for sterol 14 alpha-demethylase at the homologous locus. |
| AID274917 | Antifungal activity against fluconazole-susceptible Candida albicans | 2006 | Journal of medicinal chemistry, Dec-28, Volume: 49, Issue:26 | Synthesis, antifungal activity, and structure-activity relationships of coruscanone A analogues. |
| AID542093 | Antifungal activity against Cryptococcus neoformans ATCC 90112 after 24 hrs by microdilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Discovery of a small-molecule inhibitor of {beta}-1,6-glucan synthesis. |
| AID638565 | Antifungal activity against Cryptococcus neoformans Berkout KCCM 50564 after 1 day by two fold broth dilution method | 2012 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 22, Issue:1 | Synthesis and antifungal evaluation of pyrido[1,2-a]indole-1,4-diones and benzo[f]pyrido[1,2-a]indole-6,11-diones. |
| AID341589 | Antimicrobial activity against 10'7 CFU Cryptococcus neoformans USC1597 isolate intracranially infected in Hartley guinea pig assessed as decrease in brain bacterial count at 10 mg/kg, po BID administered 48 hrs postinfection for 13 days | 2007 | Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8 | New guinea pig model of Cryptococcal meningitis. |
| AID598227 | Antimicrobial activity against Candida krusei isolate 43 after 48 hrs by microdilution broth method | 2011 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 21, Issue:11 | Synthesis and in vitro antimicrobial activities of new (cyano-NNO-azoxy)pyrazole derivatives. |
| AID1551800 | Antibacterial activity against Staphylococcus aureus ATCC 25923 after 24 hrs by microdilution method | 2019 | European journal of medicinal chemistry, Jul-01, Volume: 173 | Antibacterial activity study of 1,2,4-triazole derivatives. |
| AID582226 | Antifungal activity against Candida krusei isolated from HSCT recipients with acute or chronic GVHD prior to initiation of posaconazole therapy assessed as maximum MIC by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Impact of antifungal prophylaxis on colonization and azole susceptibility of Candida species. |
| AID719450 | Antifungal activity against Aspergillus flavus MTCC 3306 at 1000 ug/mL after 72 hrs by well plate method | 2012 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 22, Issue:24 | Synthesis, antioxidant and antimicrobial activity of novel vanillin derived piperidin-4-one oxime esters: preponderant role of the phenyl ester substituents on the piperidin-4-one oxime core. |
| AID1695853 | Antifungal activity against Candida albicans ATCC 2091 incubated for 24 hrs by broth microdilution method | 2019 | European journal of medicinal chemistry, Apr-15, Volume: 168 | Comprehensive review on the anti-bacterial activity of 1,2,3-triazole hybrids. |
| AID1193493 | Thermodynamic equilibrium solubility, log S of the compound in PBS at pH 7.4 at RT after 4 hrs by 96 well plate method | 2015 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 25, Issue:7 | Thermodynamic equilibrium solubility measurements in simulated fluids by 96-well plate method in early drug discovery. |
| AID1890301 | Antifungal activity against Mucor circinelloides R7B wild type strain assessed as non-germinated spores and undifferentiated hyphae at 50 ug/ml by microscopic analysis | 2022 | Bioorganic & medicinal chemistry letters, 05-01, Volume: 63 | Novel 2-aryl-4-aryloxyquinoline-based fungistatics for Mucor circinelloides. Biological evaluation of activity, QSAR and docking study. |
| AID678714 | Inhibition of human CYP2C19 assessed as ratio of IC50 in absence of NADPH to IC50 for presence of NADPH using 3-butyryl-7-methoxycoumarin as substrate after 30 mins | 2012 | Chemical research in toxicology, Oct-15, Volume: 25, Issue:10 | Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds. |
| AID1157161 | Antifungal activity against Candida glabrata PMC 0805 after 48 hrs by CLSI broth microdilution method | 2014 | European journal of medicinal chemistry, Aug-18, Volume: 83 | Synthesis, biological evaluation and structure-activity correlation study of a series of imidazol-based compounds as Candida albicans inhibitors. |
| AID1380526 | Inhibition of adhesion of Candida albicans ATCC 90028 on polystyrene surface up to 25 ug/ml incubated for 90 mins by MTT assay | 2018 | Bioorganic & medicinal chemistry letters, 06-01, Volume: 28, Issue:10 | Biofilm inhibition and anti-Candida activity of a cationic lipo-benzamide molecule with twin-nonyl chain. |
| AID293415 | Antifungal activity against Aspergillus flavus NCIM 524 by serial plate dilution method | 2007 | European journal of medicinal chemistry, May, Volume: 42, Issue:5 | Synthesis of some new bioactive 3-amino-2-mercapto-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-4(3H)-one derivatives. |
| AID47865 | Evaluation of In vitro antifungal activity against Candida parapsilosis ATCC 141095 by broth macro dilution method | 1995 | Journal of medicinal chemistry, Sep-29, Volume: 38, Issue:20 | Synthesis and antifungal activity of new azole derivatives containing an N-acylmorpholine ring. |
| AID1471213 | Antifungal activity against Cryptococcus neoformans by spectrophotometric method | 2017 | Bioorganic & medicinal chemistry letters, 07-01, Volume: 27, Issue:13 | Diversity-oriented sustainable synthesis of antimicrobial spiropyrrolidine/thiapyrrolizidine oxindole derivatives: New ligands for a metallo-β-lactamase from Klebsiella pneumonia. |
| AID412147 | Antifungal activity against Aspergillus niger KCTC 1231 after 2 days | 2009 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 19, Issue:1 | Synthesis and antifungal activity of 1H-pyrrolo[3,2-g]quinoline-4,9-diones and 4,9-dioxo-4,9-dihydro-1H-benzo[f]indoles. |
| AID424908 | Antimicrobial activity against azole-resistant Candida albicans isolate CA10 assessed as growth at 64 ug/ml co-treated with 0.008 ug/ml calcineurin signaling inhibitor tacrolimus after 48 hrs by microdilution checkboard technique relative to control | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | In vitro interactions between tacrolimus and azoles against Candida albicans determined by different methods. |
| AID462238 | Antifungal activity against Candida albicans SA40 infected in Wistar rat estrogen-dependent fungal vaginitis model assessed as fungal burden at 10 ug administered intravaginally 48 hrs after fungal infection measured on day 14 after infection | 2010 | Journal of medicinal chemistry, Mar-25, Volume: 53, Issue:6 | Identification of inhibitors of drug-resistant Candida albicans strains from a library of bicyclic peptidomimetic compounds. |
| AID1201641 | Antimicrobial activity against Aspergillus flavus ATCC 9643 after 48 hrs by two-fold serial dilution method | 2015 | European journal of medicinal chemistry, May-05, Volume: 95 | Synthesis, biological evaluation and molecular docking of some substituted pyrazolines and isoxazolines as potential antimicrobial agents. |
| AID519049 | Antifungal activity against Candida tropicalis after 48 hrs by broth microdilution | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | Antimicrobial activity of omiganan pentahydrochloride against contemporary fungal pathogens responsible for catheter-associated infections. |
| AID1419478 | Antimicrobial activity against Candida albicans by two fold serial dilution method | 2017 | European journal of medicinal chemistry, May-05, Volume: 131 | Synthesis and biological evaluation of a new series of benzimidazole derivatives as antimicrobial, antiquorum-sensing and antitumor agents. |
| AID554995 | Antifungal activity against Candida glabrata assessed as percent resistant isolates at 25 ug/disc by CLSI M44-A disk diffusion method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | In vitro activities of fluconazole and voriconazole against clinical isolates of Candida spp. determined by disk diffusion testing in Turin, Italy. |
| AID1890306 | Antifungal activity against Mucor circinelloides M5 strain assessed as non-germinated spores at 100 to 150 ug/ml by microscopic analysis | 2022 | Bioorganic & medicinal chemistry letters, 05-01, Volume: 63 | Novel 2-aryl-4-aryloxyquinoline-based fungistatics for Mucor circinelloides. Biological evaluation of activity, QSAR and docking study. |
| AID555823 | Ratio of MIC50 for Candida albicans 5674 to MIC50 for cdr1/cdr1/cdr2/cdr2 deficient Candida albicans STY31 | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Relative contributions of the Candida albicans ABC transporters Cdr1p and Cdr2p to clinical azole resistance. |
| AID563120 | Antifungal activity against Candida glabrata ATCC 90030 after 48 hrs by broth microdilution method in presence of 0.2% glycerol | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | T-2307 shows efficacy in a murine model of Candida glabrata infection despite in vitro trailing growth phenomena. |
| AID352610 | Antifungal activity against Cryptococcus neoformans after 72 hrs by micro broth dilution method | 2009 | European journal of medicinal chemistry, Mar, Volume: 44, Issue:3 | 2,3-Disubstituted-1,4-naphthoquinones, 12H-benzo[b]phenothiazine-6,11-diones and related compounds: synthesis and biological evaluation as potential antiproliferative and antifungal agents. |
| AID518678 | Antimicrobial activity against Cryptococcus gattii serotype C isolate NIH298 assessed as heteroresistant isolates at 8 ug/ml | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Heteroresistance of Cryptococcus gattii to fluconazole. |
| AID211467 | Evaluation of In vitro antifungal activity against Torulopsis glabrata 78 by broth macro dilution method | 1995 | Journal of medicinal chemistry, Sep-29, Volume: 38, Issue:20 | Synthesis and antifungal activity of new azole derivatives containing an N-acylmorpholine ring. |
| AID555017 | Antifungal activity against Candida glabrata by reference dilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | In vitro activities of fluconazole and voriconazole against clinical isolates of Candida spp. determined by disk diffusion testing in Turin, Italy. |
| AID555571 | Antimicrobial activity against Candida guilliermondii by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Activity profile in vitro of micafungin against Spanish clinical isolates of common and emerging species of yeasts and molds. |
| AID1698053 | Antifungal activity against Saccharomyces cerevisiae assessed as inhibition of bacterial growth incubated for overnight by CLSI based method | 2020 | Bioorganic & medicinal chemistry letters, 11-15, Volume: 30, Issue:22 | Design and synthesis of new indanol-1,2,3-triazole derivatives as potent antitubercular and antimicrobial agents. |
| AID566878 | Antifungal activity against Candida parapsilosis by microdilution test | 2011 | European journal of medicinal chemistry, Jan, Volume: 46, Issue:1 | Synthesis and antifungal activity of some substituted phenothiazines and related compounds. |
| AID1770953 | Inhibition of CYP51 in Candida albicans assessed as 14alpha-methylfecosterol level at 0.25 ug/ml measured after 18 hrs by GC-MS analysis relative to control | 2021 | European journal of medicinal chemistry, Dec-05, Volume: 225 | Design, synthesis and evaluation of novel 5-phenylthiophene derivatives as potent fungicidal of Candida albicans and antifungal reagents of fluconazole-resistant fungi. |
| AID1864937 | Induction of apoptosis in Candida albicans ATCC SC5314 assessed as late apoptotic cells incuabted for 24 hrs by V-FITC/PI staining based flow cytometry analysis (Rvb = 0.36%) | |||
| AID352121 | Antifungal activity against Aspergillus niger after 26 hrs by serial plate dilution method | 2009 | European journal of medicinal chemistry, Mar, Volume: 44, Issue:3 | Antimicrobial studies of some novel quinazolinones fused with [1,2,4]-triazole, [1,2,4]-triazine and [1,2,4,5]-tetrazine rings. |
| AID434896 | Antifungal activity against Candida tropicalis isolate 8 in RPMI 1640 medium by broth dilution susceptibility test | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | In vitro study of Candida tropicalis isolates exhibiting paradoxical growth in the presence of high concentrations of caspofungin. |
| AID1322104 | Antimicrobial activity against Candida albicans ATCC 60193 after 24 hrs by broth microdilution assay | 2016 | Bioorganic & medicinal chemistry, 11-01, Volume: 24, Issue:21 | Synthesis, characterization, and evaluation of (E)-methyl 2-((2-oxonaphthalen-1(2H)-ylidene)methylamino)acetate as a biological agent and an anion sensor. |
| AID1254316 | Antifungal activity against Candida tropicalis 156 after 24 hrs by microdilution broth method | 2015 | Bioorganic & medicinal chemistry, Nov-15, Volume: 23, Issue:22 | Novel derivatives of nitro-substituted salicylic acids: Synthesis, antimicrobial activity and cytotoxicity. |
| AID582253 | Antifungal activity against Candida glabrata isolated from neutropenic subjects with AML or MDS prior to initiation of fluconazole therapy by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Impact of antifungal prophylaxis on colonization and azole susceptibility of Candida species. |
| AID619186 | Antifungal activity against Candida parapsilosis AN 5485 by broth dilution method | 2011 | Journal of medicinal chemistry, Oct-13, Volume: 54, Issue:19 | High-throughput-screening-based identification and structure-activity relationship characterization defined (S)-2-(1-aminoisobutyl)-1-(3-chlorobenzyl)benzimidazole as a highly antimycotic agent nontoxic to cell lines. |
| AID1309055 | Antifungal activity against Candida parapsilosis ATCC 22019 after 48 hrs by CLSI M27-A3 method | 2016 | Bioorganic & medicinal chemistry, 08-15, Volume: 24, Issue:16 | Synthesis and investigation of novel benzimidazole derivatives as antifungal agents. |
| AID462237 | Antifungal activity against Candida albicans SA40 infected in Wistar rat estrogen-dependent fungal vaginitis model assessed as fungal burden at 10 ug administered intravaginally 48 hrs after fungal infection measured on day 21 after infection | 2010 | Journal of medicinal chemistry, Mar-25, Volume: 53, Issue:6 | Identification of inhibitors of drug-resistant Candida albicans strains from a library of bicyclic peptidomimetic compounds. |
| AID470596 | Antifungal activity against Candida albicans after 48 hrs by microbroth dilution technique | 2009 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 19, Issue:18 | Design and synthesis of bile acid-based amino sterols as antimicrobial agents. |
| AID519469 | Antimicrobial activity against Cryptococcus albidus by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | In Vitro activity of the new azole isavuconazole (BAL4815) compared with six other antifungal agents against 162 Cryptococcus neoformans isolates from Cuba. |
| AID405047 | Antifungal activity against Sporothrix schenckii SSA29 isolate from cutaneous-lymphatic sporotrichosis patient after 72 hrs by ATB Fungus 2 method | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | In vitro susceptibility of Sporothrix schenckii to six antifungal agents determined using three different methods. |
| AID1193896 | Antifungal activity against Penicillium notatum after 48 hrs by broth dilution method | 2015 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 25, Issue:7 | Rapid 'one-pot' synthesis of a novel benzimidazole-5-carboxylate and its hydrazone derivatives as potential anti-inflammatory and antimicrobial agents. |
| AID521794 | Fungistatic activity against Candida glabrata 4370 assessed as 99.9% reduction of int initial fungal load at 0.5 times MIC after 48 hrs using colony count method by time-kill method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Posaconazole against Candida glabrata isolates with various susceptibilities to fluconazole. |
| AID1759429 | Inhibition of ergosterol biosynthesis in Cryptococcus neoformans PFCC 93-589 cell membrane assessed as ergosterol content at 0.5 times MIC incubated for 48 hrs by UV-visible spectrophotometric analysis (Rvb = 0.134 No_unit) | 2021 | Bioorganic & medicinal chemistry letters, 06-01, Volume: 41 | Inhibitory effects and mechanism of antifungal action of the natural cyclic depsipeptide, aureobasidin A against Cryptococcus neoformans. |
| AID581874 | Antifungal activity against Candida glabrata isolated from neutropenic subject 1497 with AML or MDS pharynx after 61 days prophylaxis by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Impact of antifungal prophylaxis on colonization and azole susceptibility of Candida species. |
| AID626348 | Antifungal activity against Chrysosporium keratinophilum MTCC 2827 at 0.25 mg/mL after 72 hrs by by agar-well diffusion method | 2011 | European journal of medicinal chemistry, Nov, Volume: 46, Issue:11 | Hantzsch reaction: synthesis and characterization of some new 1,4-dihydropyridine derivatives as potent antimicrobial and antioxidant agents. |
| AID546079 | Antifungal activity against Candida lipolytica isolated from candidemia patient by AFST-EUCAST microdilution method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | A 10-year survey of antifungal susceptibility of candidemia isolates from intensive care unit patients in Greece. |
| AID547353 | Antifungal activity against Candida lusitaniae after 24 to 72 hrs by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | In vitro antifungal activities of bis(alkylpyridinium)alkane compounds against pathogenic yeasts and molds. |
| AID509285 | Permeability across BBMEC cocultured with rat C6 cell BBB model after 24 hrs in presence of 0.1 ug/ml tacrolimus-506 | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Effects of immunomodulatory and organism-associated molecules on the permeability of an in vitro blood-brain barrier model to amphotericin B and fluconazole. |
| AID1877834 | Antifungal activity against Candida albicans CA3816 by microdilution method | 2022 | Bioorganic & medicinal chemistry letters, 02-15, Volume: 58 | Synthesis and antifungal evaluation of phenol-derived bis(indolyl)methanes combined with FLC against Candida albicans. |
| AID584388 | Antifungal activity against 42 days cultured Candida glabrata isolated from neutropenic subject with AML or MDS stool after 48 days of prophylaxis by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Impact of antifungal prophylaxis on colonization and azole susceptibility of Candida species. |
| AID1247369 | Antifungal activity against Candida albicans SC5314 after 24 hrs by serial dilution method | 2015 | European journal of medicinal chemistry, Sep-18, Volume: 102 | Design, synthesis, and structure-activity relationship studies of novel thienopyrrolidone derivatives with strong antifungal activity against Aspergillus fumigates. |
| AID1369481 | Antifungal activity against Candida albicans cgmcc 2.2086 in presence of CaCl2 by broth dilution method | 2018 | Journal of medicinal chemistry, 05-10, Volume: 61, Issue:9 | Combating Drug-Resistant Fungi with Novel Imperfectly Amphipathic Palindromic Peptides. |
| AID1472817 | Antifungal activity against itraconazole and fluconazole susceptible Candida albicans ATCC MYA-2310 after 48 hrs by broth dilution method | 2018 | Journal of medicinal chemistry, 01-11, Volume: 61, Issue:1 | Alkylated Piperazines and Piperazine-Azole Hybrids as Antifungal Agents. |
| AID1719180 | Antifungal activity against fluconazole-sensitive Candida albicans Gu4 assessed as reduction in microbial growth | 2021 | Bioorganic & medicinal chemistry letters, 03-01, Volume: 35 | A new 1-nitro-9-aminoacridine derivative targeting yeast topoisomerase II able to overcome fluconazole-resistance. |
| AID602932 | Antifungal activity against Trichophyton rubrum by micro-broth dilution method | 2011 | European journal of medicinal chemistry, Jul, Volume: 46, Issue:7 | Design, synthesis and antifungal evaluation of 1-(2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propyl)-1H-1,2,4-triazol-5(4H)-one. |
| AID1918335 | Antifungal activity against Candida tropicalis ATCC 1369 assessed as inhibition of fungal growth measured after 72 hrs by CLSI based liquid medium dilution method | 2022 | Journal of medicinal chemistry, 11-10, Volume: 65, Issue:21 | Novel Aryl Alkamidazole Derivatives as Multifunctional Antifungal Inhibitors: Design, Synthesis, and Biological Evaluation. |
| AID1239799 | Antifungal activity against Candida albicans ATCC 10231 at 50 ug/ml after 48 hrs by cup plate method | 2015 | Bioorganic & medicinal chemistry letters, Sep-01, Volume: 25, Issue:17 | Design, synthesis and evaluation of benzotriazole derivatives as novel antifungal agents. |
| AID1859326 | Antimicrobial activity against Candida albicans 904 | 2022 | Journal of medicinal chemistry, 02-24, Volume: 65, Issue:4 | Application of the All-Hydrocarbon Stapling Technique in the Design of Membrane-Active Peptides. |
| AID497806 | Antifungal activity against fluconazole-resistant Candida glabrata isolate 04 by broth microdilution assay | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Assessment of the in vitro kinetic activity of caspofungin against Candida glabrata. |
| AID1742145 | Inhibition of CYP51 in Candida albicans ATCC SC5314 assessed as ergosterol level at 4 ug/ml incubated for 16 hrs by LC/MS analysis (Rvb = 79.43 %) | 2020 | European journal of medicinal chemistry, Nov-01, Volume: 205 | Design, synthesis and bioactivity evaluation of novel arylalkene-amide derivatives as dual-target antifungal inhibitors. |
| AID1201631 | Antimicrobial activity against Aspergillus versicolor ATCC 10072 assessed as diameter of zone of inhibition at 20 microg/disc after 24 hrs by agar well diffusion method | 2015 | European journal of medicinal chemistry, May-05, Volume: 95 | Synthesis, biological evaluation and molecular docking of some substituted pyrazolines and isoxazolines as potential antimicrobial agents. |
| AID1728517 | Inhibition of CYP51 in Candida albicans ATCC SC5314 assessed as eburicol level at 4 ug/ml incubated for 48 hrs by LC/MS analysis (Rvb = 1.4 %) | 2021 | European journal of medicinal chemistry, Jan-15, Volume: 210 | Novel naphthylamide derivatives as dual-target antifungal inhibitors: Design, synthesis and biological evaluation. |
| AID497803 | Antifungal activity against fluconazole-resistant Candida glabrata isolate 01 by broth microdilution assay | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Assessment of the in vitro kinetic activity of caspofungin against Candida glabrata. |
| AID542082 | Antifungal activity against Saccharomyces cerevisiae YPH500 after 24 hrs by microdilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Discovery of a small-molecule inhibitor of {beta}-1,6-glucan synthesis. |
| AID1180171 | Antifungal activity against Candida albicans R303 infected in CD-1 mouse assessed as reduction of kidney fungal burden at 10 mg/kg, po administered 2 hrs post infection on day 1 measured on day 2 relative to vehicle-treated control | 2014 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 24, Issue:15 | Design and optimization of highly-selective fungal CYP51 inhibitors. |
| AID1379941 | Antifungal activity against Candida sake clinical isolates assessed as inhibition of microbial growth incubated for 24 hrs by broth microdilution method | 2017 | European journal of medicinal chemistry, Nov-10, Volume: 140 | Synthesis, biological evaluation and quantitative structure-active relationships of 1,3-thiazolidin-4-one derivatives. A promising chemical scaffold endowed with high antifungal potency and low cytotoxicity. |
| AID1557074 | Antifungal activity against ERG11/ERG3 knocked out Candida albicans SN152 assessed as zone of inhibition at 25 ug incubated for 48 hrs by disk diffusion method | 2019 | European journal of medicinal chemistry, Oct-01, Volume: 179 | Antifungal activity, mode of action variability, and subcellular distribution of coumarin-based antifungal azoles. |
| AID1820637 | Antifungal activity against Candida albicans SC5314 assessed as inhibition of fungal growth by NCCLS protocol based method | 2022 | European journal of medicinal chemistry, Jan-15, Volume: 228 | Design, synthesis, and biological activity evaluation of 2-(benzo[b]thiophen-2-yl)-4-phenyl-4,5-dihydrooxazole derivatives as broad-spectrum antifungal agents. |
| AID555018 | Antifungal activity against Candida tropicalis by reference dilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | In vitro activities of fluconazole and voriconazole against clinical isolates of Candida spp. determined by disk diffusion testing in Turin, Italy. |
| AID424907 | Antimicrobial activity against azole-resistant Candida albicans isolate CA10 assessed as growth at 32 ug/ml co-treated with 0.008 ug/ml calcineurin signaling inhibitor tacrolimus after 48 hrs by microdilution checkboard technique relative to control | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | In vitro interactions between tacrolimus and azoles against Candida albicans determined by different methods. |
| AID333836 | Antifungal activity against azole-sensitive Candida albicans by broth microdilution assay | 2005 | Journal of natural products, Dec, Volume: 68, Issue:12 | Antifungal flavonoids from Hildegardia barteri. |
| AID293417 | Antifungal activity against Trichophyton mentagrophytes by serial plate dilution method | 2007 | European journal of medicinal chemistry, May, Volume: 42, Issue:5 | Synthesis of some new bioactive 3-amino-2-mercapto-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-4(3H)-one derivatives. |
| AID1491252 | Inhibition of CYP51 in Candida albicans ATCC SC5314 assessed as ergosterol content at 0.125 ug/ml by GS-MS analysis relative to total sterols (Rvb = 98.7%) | 2017 | European journal of medicinal chemistry, Sep-08, Volume: 137 | Design, synthesis and evaluation of aromatic heterocyclic derivatives as potent antifungal agents. |
| AID1557077 | Antifungal activity against Candida albicans SN152 assessed as reduction in fungal cell growth incubated for 24 hrs by MTT based broth double dilution method | 2019 | European journal of medicinal chemistry, Oct-01, Volume: 179 | Antifungal activity, mode of action variability, and subcellular distribution of coumarin-based antifungal azoles. |
| AID1762153 | Antifungal activity against Candida albicans 8R assessed as reduction in fungal growth incubated for 48 hrs by CLSI based serial microbroth dilution method | 2021 | Bioorganic & medicinal chemistry letters, 05-15, Volume: 40 | Synthesis and antifungal activity of new hybrids thiazolo[4,5-d]pyrimidines with (1H-1,2,4)triazole. |
| AID547600 | Antifungal activity against Candida glabrata isolate Cg21S | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | Microarray and molecular analyses of the azole resistance mechanism in Candida glabrata oropharyngeal isolates. |
| AID1154837 | Antifungal activity against fluconazole-resistant Candida albicans 07109 after 24 hrs by serial dilution method | 2014 | ACS medicinal chemistry letters, May-08, Volume: 5, Issue:5 | Novel carboline derivatives as potent antifungal lead compounds: design, synthesis, and biological evaluation. |
| AID521801 | Antifungal activity against fluconazole-resistant Candida glabrata isolate 4198 infected neutropenic CD1 mouse disseminated candidiasis model assessed as reduction in kidney tissue fungal burden at 30 mg/kg/day, po administered 24 hrs post infection measu | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Posaconazole against Candida glabrata isolates with various susceptibilities to fluconazole. |
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| AID1059359 | Fungicidal activity against Candida glabrata by micro dilution method | 2013 | European journal of medicinal chemistry, , Volume: 70 | Designing and synthesis of novel antimicrobial heterocyclic analogs of fatty acids. |
| AID1427208 | Antifungal activity against Aspergillus fumigatus 231 after 24 hrs by microdilution broth assay | 2017 | Bioorganic & medicinal chemistry, 03-15, Volume: 25, Issue:6 | Antimicrobial activity of rhodanine-3-acetic acid derivatives. |
| AID1598042 | Antifungal activity against Candida krusei after 24 hrs | 2019 | European journal of medicinal chemistry, May-15, Volume: 170 | Current advances of triazole alcohols derived from fluconazole: Design, in vitro and in silico studies. |
| AID364888 | Antifungal activity against Candida albicans ATCC 10231 after 48 hrs by broth macrodilution method | 2008 | Bioorganic & medicinal chemistry, Sep-01, Volume: 16, Issue:17 | Antifungal activity of synthetic di(hetero)arylamines based on the benzo[b]thiophene moiety. |
| AID584378 | Ratio of CDR1 gene expression in Candida glabrata isolated from patient 807 receiving antifungal drug to CDR1 gene expression in Candida glabrata isolated from patient 807 by RT-PCR analysis | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Impact of antifungal prophylaxis on colonization and azole susceptibility of Candida species. |
| AID1383443 | Inhibition of recombinant Trypanosoma cruzi Tulahuen CYP51 expressed in Escherichia coli JM109 cell membranes assessed as inhibition of microbe growth by fluorescence based analysis | 2018 | European journal of medicinal chemistry, Apr-10, Volume: 149 | Identification of Pyrazolo[3,4-e][1,4]thiazepin based CYP51 inhibitors as potential Chagas disease therapeutic alternative: In vitro and in vivo evaluation, binding mode prediction and SAR exploration. |
| AID285692 | Inhibition of Candida albicans ATCC 32354 at 1 ug/ml by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Neonatal coinfection model of coagulase-negative Staphylococcus (Staphylococcus epidermidis) and Candida albicans: fluconazole prophylaxis enhances survival and growth. |
| AID428421 | Antifungal activity against Trichophyton rubrum after 48 hrs by agar dilution method | 2009 | European journal of medicinal chemistry, Jul, Volume: 44, Issue:7 | Design, synthesis, and antifungal activity of triazole and benzotriazole derivatives. |
| AID555588 | Antimicrobial activity against Galactomyces geotrichum by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Activity profile in vitro of micafungin against Spanish clinical isolates of common and emerging species of yeasts and molds. |
| AID1300881 | Antifungal activity against Candida krusei clinical isolate after 24 hrs by broth microdilution method | 2016 | European journal of medicinal chemistry, Jul-19, Volume: 117 | Novel 1,3-thiazolidin-4-one derivatives as promising anti-Candida agents endowed with anti-oxidant and chelating properties. |
| AID1419522 | Effect on sterol composition in Candida albicans ATCC 10231 assessed as lanosterol level at 0.125 ug/mL incubated for 10 mins by LC-MS analysis (Rvb = 4.17%) | 2017 | European journal of medicinal chemistry, Jun-16, Volume: 133 | Novel alkylated azoles as potent antifungals. |
| AID39536 | Compound was tested in vitro for antifungal activity against Aspergillus fumigatus (CF1004) in experiment 2 | 1998 | Bioorganic & medicinal chemistry letters, Jul-21, Volume: 8, Issue:14 | Modeling, synthesis and biological activity of novel antifungal agents (1). |
| AID1885999 | Antifungal activity against Cryptococcus neoformans clinical isolate 444 assessed as fungal growth inhibition incubated for 72 hrs in presence of P163-0892 by broth microdilution method | |||
| AID462223 | Antifungal activity against pharmacoresistant Candida albicans AIDS68 infected in Wistar rat estrogen-dependent fungal vaginitis model assessed as fungal burden at 10 ug administered intravaginally 48 hrs after fungal infection measured on day 7 after inf | 2010 | Journal of medicinal chemistry, Mar-25, Volume: 53, Issue:6 | Identification of inhibitors of drug-resistant Candida albicans strains from a library of bicyclic peptidomimetic compounds. |
| AID48806 | Minimum inhibitory concentration of compound for antifungal activity against Candida tropicalis | 2000 | Bioorganic & medicinal chemistry letters, Oct-02, Volume: 10, Issue:19 | Novel antifungals based on 4-substituted imidazole: a combinatorial chemistry approach to lead discovery and optimization. |
| AID1242639 | Antibacterial activity against Escherichia coli ATCC 9637 after 16 hrs by microtiter broth dilution method | 2015 | ACS medicinal chemistry letters, Jul-09, Volume: 6, Issue:7 | Novel Chalcone-Thiazole Hybrids as Potent Inhibitors of Drug Resistant Staphylococcus aureus. |
| AID1600165 | Antifungal activity against Rhodotorula glutinis NCIM 3168 assessed as zone of inhibition at 80 ug/well incubated for 48 to 72 hrs by by agar well diffusion method | 2019 | European journal of medicinal chemistry, Oct-01, Volume: 179 | Synthesis of new thiazolyl-pyrazolyl-1,2,3-triazole derivatives as potential antimicrobial agents. |
| AID9231 | In vitro antifungal activity against Aspergillus fumigatus 48238E | 2002 | Journal of medicinal chemistry, Oct-24, Volume: 45, Issue:22 | Synthesis, antifungal activity, and molecular modeling studies of new inverted oxime ethers of oxiconazole. |
| AID1076167 | Antifungal activity against Candida albicans by broth dilution method | 2014 | European journal of medicinal chemistry, Mar-21, Volume: 75 | Synthesis and antimicrobial evaluation of amide derivatives of benzodifuran-2-carboxylic acid. |
| AID1886048 | Synergistic antifungal activity against Cryptococcus neoformans clinical isolate 443 assessed as fractional inhibitory concentration index incubated for 72 hrs in presence of P163-0892 by broth microdilution method | |||
| AID522121 | Antimicrobial activity against deltacrz1 mutant containing Candida glabrata TG173 complemented with CRZ1 gene assessed as reduction in bacterial cell viability by time kill study | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Roles of calcineurin and Crz1 in antifungal susceptibility and virulence of Candida glabrata. |
| AID1205758 | Antifungal activity against Cryptococcus neoformans ATCC 62066 after 72 hrs by microdilution method | 2015 | ACS medicinal chemistry letters, Mar-12, Volume: 6, Issue:3 | Synthesis of a New Peptide-Coumarin Conjugate: A Potential Agent against Cryptococcosis. |
| AID1419544 | Selectivity index, ratio of EC50 for toxicity in human BEAS2B cells to MIC50 for antifungal activity against ITC and FLC-susceptible Candida albicans ATCC MYA-2876 | 2017 | European journal of medicinal chemistry, Jun-16, Volume: 133 | Novel alkylated azoles as potent antifungals. |
| AID1624171 | Antifungal activity against Candida albicans NR-29437 after 24 hrs by microbroth dilution method | 2019 | Bioorganic & medicinal chemistry letters, 03-01, Volume: 29, Issue:5 | Benzimidazole tethered pyrrolo[3,4-b]quinoline with broad-spectrum activity against fungal pathogens. |
| AID1918360 | Inhibition of CYP51 in Candida albicans ATCC SC5314 assessed as ergosterol content at 4 ug/ml measured after 48 hrs by GC-MS analysis (Rvb = 95.61%) | 2022 | Journal of medicinal chemistry, 11-10, Volume: 65, Issue:21 | Novel Aryl Alkamidazole Derivatives as Multifunctional Antifungal Inhibitors: Design, Synthesis, and Biological Evaluation. |
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| AID1232311 | Unbound volume of distribution at steady state in human | 2015 | Journal of medicinal chemistry, Aug-13, Volume: 58, Issue:15 | Volume of Distribution in Drug Design. |
| AID752002 | Antifungal activity against Aspergillus niger NCIM 1196 by agar dilution method | 2013 | Bioorganic & medicinal chemistry letters, May-01, Volume: 23, Issue:9 | Green synthesis of tetrahydropyrimidine analogues and evaluation of their antimicrobial activity. |
| AID644840 | Antifungal activity against Candida krusei after 48 hrs by M27-A3 CLSI method | 2012 | European journal of medicinal chemistry, Mar, Volume: 49 | Synthesis and antifungal activity of a new series of 2-(1H-imidazol-1-yl)-1-phenylethanol derivatives. |
| AID537530 | Antifungal activity against Candida glabrata after 48 hrs by broth microdilution method | 2010 | Bioorganic & medicinal chemistry, Nov-15, Volume: 18, Issue:22 | Synthesis of new antifungal peptides selective against Cryptococcus neoformans. |
| AID245688 | In vitro minimal inhibitory concentration against Candida albicans with percentage of resistant strains %R = 45.45 (MIC > 64 ug/mL) at a range of 0.125-0.5 ug/mL | 2005 | Journal of medicinal chemistry, Aug-11, Volume: 48, Issue:16 | Antifungal agents. 11. N-substituted derivatives of 1-[(aryl)(4-aryl-1H-pyrrol-3-yl)methyl]-1H-imidazole: synthesis, anti-Candida activity, and QSAR studies. |
| AID1556539 | Antifungal activity against Candida albicans ATCC 90023 assessed as reduction in fungal cell viability incubated for 24 hrs by two fold serial dilution method | 2019 | European journal of medicinal chemistry, Oct-01, Volume: 179 | A new exploration towards aminothiazolquinolone oximes as potentially multi-targeting antibacterial agents: Design, synthesis and evaluation acting on microbes, DNA, HSA and topoisomerase IV. |
| AID565397 | Antifungal activity against Rhizopus microsporus FMR 3542 by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Correlation of in vitro activity, serum levels, and in vivo efficacy of posaconazole against Rhizopus microsporus in a murine disseminated infection. |
| AID1415613 | Antifungal activity against fluconazole-resistant Candida krusei clinical isolate 2159 by broth microdilution method | 2017 | MedChemComm, May-01, Volume: 8, Issue:5 | Synthesis and synergistic antifungal effects of monoketone derivatives of curcumin against fluconazole-resistant |
| AID1244345 | Antifungal activity against Trichophyton mentagrophytes incubated for 48 hrs by broth micro-dilution method | 2015 | European journal of medicinal chemistry, Aug-28, Volume: 101 | N-Alkyl/aryl-4-(3-substituted-3-phenylpropyl)piperazine-1-carbothioamide as dual-action vaginal microbicides with reverse transcriptase inhibition. |
| AID293783 | Antimicrobial activity against Cryptococcus neoformans var.neoformans serotype D ATCC 28952 by broth microdilution method | 2007 | Bioorganic & medicinal chemistry, Mar-01, Volume: 15, Issue:5 | Synthesis, antimicrobial activity, and QSAR studies of furan-3-carboxamides. |
| AID555567 | Antimicrobial activity against Candida parapsilosis by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Activity profile in vitro of micafungin against Spanish clinical isolates of common and emerging species of yeasts and molds. |
| AID1193492 | Thermodynamic equilibrium solubility, log S of the compound in water at RT after 4 hrs by 96 well plate method | 2015 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 25, Issue:7 | Thermodynamic equilibrium solubility measurements in simulated fluids by 96-well plate method in early drug discovery. |
| AID518432 | Antimicrobial activity against Cryptococcus gattii serotype B isolate NIH198 assessed as heteroresistant isolates at 4 ug/ml | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Heteroresistance of Cryptococcus gattii to fluconazole. |
| AID715632 | Antifungal activity against Aspergillus fumigatus MTCC 2550 after 72 hrs by serial dilution method | 2012 | European journal of medicinal chemistry, Nov, Volume: 57 | Synthesis, characterization, biological evaluation and QSAR studies of 11-p-substituted phenyl-12-phenyl-11a,12-dihydro-11H-indeno[2,1-c][1,5]benzothiazepines as potential antimicrobial agents. |
| AID1818271 | Antifungal activity against Candida krusei ATCC 6258 assessed as reduction in fungal growth incubated for 72 hrs by CLSI protocol based broth microdilution method | |||
| AID582242 | Antifungal activity against Candida glabrata isolated from HSCT recipients with acute or chronic GVHD prior to initiation of fluconazole therapy by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Impact of antifungal prophylaxis on colonization and azole susceptibility of Candida species. |
| AID1168345 | Ratio of binding constant for human serum albumin in presence of Zn2+ to binding constant for human serum albumin in absence of metal ions | 2014 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 24, Issue:21 | Study the interactions between human serum albumin and two antifungal drugs: fluconazole and its analogue DTP. |
| AID525542 | Antimicrobial activity against Fonsecaea pedrosoi isolates after 72 hrs by CLSI M38-A2 protocol method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | In vitro activities of eight antifungal drugs against 55 clinical isolates of Fonsecaea spp. |
| AID1598000 | Antifungal activity against Microsporum gypseum after 7 days by NCCLS protocol based method | 2019 | European journal of medicinal chemistry, May-15, Volume: 170 | Current advances of triazole alcohols derived from fluconazole: Design, in vitro and in silico studies. |
| AID1885969 | Antifungal activity against Cryptococcus neoformans clinical isolate HN17 assessed as fungal growth inhibition incubated for 72 hrs by broth microdilution method | |||
| AID750287 | Antifungal activity against Candida parapsilosis ATCC 22019 after 24 to 48 hrs by broth microdilution method | 2013 | European journal of medicinal chemistry, Jun, Volume: 64 | 2-Aminobenzothiazole derivatives: search for new antifungal agents. |
| AID1890296 | Inhibition of CYP51 in mouse NIH/3T3 cells assessed as specific enzymatic activity at 200 ug/ml incubated for 48 hrs by ELISA analysis | 2022 | Bioorganic & medicinal chemistry letters, 05-01, Volume: 63 | Novel 2-aryl-4-aryloxyquinoline-based fungistatics for Mucor circinelloides. Biological evaluation of activity, QSAR and docking study. |
| AID1473741 | Inhibition of human MRP4 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and GSH measured after 20 mins by membrane vesicle transport assay | 2013 | Toxicological sciences : an official journal of the Society of Toxicology, Nov, Volume: 136, Issue:1 | A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. |
| AID537525 | Antifungal activity against Candida parapsilosis after 48 hrs by broth microdilution method | 2010 | Bioorganic & medicinal chemistry, Nov-15, Volume: 18, Issue:22 | Synthesis of new antifungal peptides selective against Cryptococcus neoformans. |
| AID1246582 | Antifungal activity against Cryptococcus gattii L27/01 after 48 to 72 hrs by broth microdilution method | 2015 | European journal of medicinal chemistry, Sep-18, Volume: 102 | Thiazole compounds with activity against Cryptococcus gattii and Cryptococcus neoformans in vitro. |
| AID42857 | Inhibition of Candida albicans ATCC 90028 for 24 hours in vitro. | 2001 | Journal of medicinal chemistry, Aug-16, Volume: 44, Issue:17 | 3-Phenyl-5-acyloxymethyl-2H,5H-furan-2-ones: synthesis and biological activity of a novel group of potential antifungal drugs. |
| AID582798 | Antifungal activity against Candida albicans isolate 177 by broth dilution method | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | Identification and characterization of four azole-resistant erg3 mutants of Candida albicans. |
| AID757549 | Anticandida activity against Candida tropicalis clinical isolate assessed as growth inhibition after 24 hrs by broth microdilution method | 2013 | European journal of medicinal chemistry, Jul, Volume: 65 | Synthesis and cytotoxicity of novel (thiazol-2-yl)hydrazine derivatives as promising anti-Candida agents. |
| AID613454 | Antifungal activity against Benjaminiella poitrasii isolate NCL3 after 24 hrs by M38-P broth dilution method | 2011 | European journal of medicinal chemistry, Sep, Volume: 46, Issue:9 | Stereoselective synthesis and antimicrobial activity of steroidal C-20 tertiary alcohols with thiazole/pyridine side chain. |
| AID1246665 | Antifungal activity against Cryptococcus gattii L27/01 assessed as reduction in cell viability at 26 uM after 6 to 72 hrs by MTT assay | 2015 | European journal of medicinal chemistry, Sep-18, Volume: 102 | Thiazole compounds with activity against Cryptococcus gattii and Cryptococcus neoformans in vitro. |
| AID369386 | Antimicrobial activity against Rhodotorula mucilaginosa isolate | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | In vitro susceptibility to posaconazole of 1,903 yeast isolates recovered in France from 2003 to 2006 and tested by the method of the European committee on antimicrobial susceptibility testing. |
| AID405067 | Antifungal activity against Candida krusei ATCC 6258 isolate from cutaneous-lymphatic sporotrichosis patient after 72 hrs by Sensititre YeastOne method | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | In vitro susceptibility of Sporothrix schenckii to six antifungal agents determined using three different methods. |
| AID1885990 | Antifungal activity against Cryptococcus neoformans clinical isolate HN2 assessed as fungal growth inhibition incubated for 72 hrs in presence of P163-0892 by broth microdilution method | |||
| AID477337 | Antifungal activity against Candida parapsilosis ATCC 22019 after 48 to 72 hrs by microdilution method | 2010 | European journal of medicinal chemistry, Apr, Volume: 45, Issue:4 | Synthesis and characterization of novel fatty acid analogs of cholesterol: in vitro antimicrobial activity. |
| AID518880 | Antimicrobial activity against Cryptococcus gattii serotype B isolate NIH409 assessed as heteroresistant isolates at 32 ug/ml | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Heteroresistance of Cryptococcus gattii to fluconazole. |
| AID608678 | Antifungal activity against Aspergillus flavus at 1000 ug/ml after 72 hrs by agar diffusion method | 2011 | European journal of medicinal chemistry, Aug, Volume: 46, Issue:8 | Synthesis, characterization and antimicrobial studies of some new pyrazole incorporated imidazole derivatives. |
| AID653259 | Antifungal activity against Cryptococcus neoformans ATCC 90012 after 24 hrs by broth microdilution method | 2012 | Bioorganic & medicinal chemistry, Apr-15, Volume: 20, Issue:8 | Semisynthesis and antimicrobial activity of novel guttiferone-A derivatives. |
| AID1061739 | Antimicrobial activity against Candida glabrata by broth microdilution method | 2014 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 24, Issue:1 | Synthesis and evaluation of novel azoles as potent antifungal agents. |
| AID750202 | Antifungal activity against Trichosporon asahii after 48 hrs by CLSI M27A3 broth microdilution method | 2013 | European journal of medicinal chemistry, Jun, Volume: 64 | Synthesis, antifungal and cytotoxic activities of 2-aryl-3-((piperidin-1-yl)ethyl)thiazolidinones. |
| AID1493832 | Antifungal activity against Trichophyton rubrum Cmccftla after 24 hrs by spectrophotometric analysis | 2018 | European journal of medicinal chemistry, Jan-01, Volume: 143 | Discovery of simplified sampangine derivatives as novel fungal biofilm inhibitors. |
| AID1762163 | Antifungal activity against Cryptococcus neoformans assessed as reduction in fungal growth incubated for 48 hrs by CLSI based serial microbroth dilution method | 2021 | Bioorganic & medicinal chemistry letters, 05-15, Volume: 40 | Synthesis and antifungal activity of new hybrids thiazolo[4,5-d]pyrimidines with (1H-1,2,4)triazole. |
| AID1331129 | Antibiofilm activity against mature biofilm of Candida albicans ATCC 10231 after 24 hrs by XTT reduction assay | |||
| AID670554 | Antifungal activity against Candida albicans MTCC 7315 after 24 hrs by well diffusion method | 2012 | Bioorganic & medicinal chemistry letters, Jul-15, Volume: 22, Issue:14 | Total synthesis and antifungal activity of (2S,3R)-2-aminododecan-3-ol. |
| AID717903 | Antimicrobial activity against Candida albicans ATCC 44859 after 24 hrs by broth microdilution test | 2012 | Bioorganic & medicinal chemistry, Dec-15, Volume: 20, Issue:24 | Contribution to investigation of antimicrobial activity of styrylquinolines. |
| AID1246765 | Cytotoxicity against African green monkey Vero cells assessed as cell viability measured after 48 hrs by MTT assay | 2015 | European journal of medicinal chemistry, Sep-18, Volume: 102 | Thiazole compounds with activity against Cryptococcus gattii and Cryptococcus neoformans in vitro. |
| AID1335844 | Antifungal activity against Candida mycoderma after 24 hrs by two fold serial dilution method | 2016 | European journal of medicinal chemistry, Nov-29, Volume: 124 | Multi-targeting exploration of new 2-aminothiazolyl quinolones: Synthesis, antimicrobial evaluation, interaction with DNA, combination with topoisomerase IV and penetrability into cells. |
| AID424890 | Antimicrobial activity against azole-resistant Candida albicans isolate CA10 assessed as growth at 0.5 ug/ml co-treated with 0.016 ug/ml calcineurin signaling inhibitor tacrolimus after 48 hrs by microdilution checkboard technique relative to control | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | In vitro interactions between tacrolimus and azoles against Candida albicans determined by different methods. |
| AID582224 | Antifungal activity against Candida glabrata isolated from HSCT recipients with acute or chronic GVHD prior to initiation of posaconazole therapy assessed as maximum MIC by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Impact of antifungal prophylaxis on colonization and azole susceptibility of Candida species. |
| AID1235493 | Inhibition of ergosterol biosynthesis in Candida tropicalis 2356 assessed as ergosterol content after 16 hrs by spectrophotometer analysis | 2015 | Bioorganic & medicinal chemistry, Aug-01, Volume: 23, Issue:15 | Imidazole clubbed 1,3,4-oxadiazole derivatives as potential antifungal agents. |
| AID518146 | Antimicrobial activity against Cryptococcus gattii serotype B isolate VPB571-058 assessed as concentration required for heteroresistance | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Heteroresistance of Cryptococcus gattii to fluconazole. |
| AID1595107 | Antifungal activity against Candida albicans assessed as reduction in fungal cell growth incubated for 48 hrs by broth microdilution susceptibility method | 2019 | European journal of medicinal chemistry, May-15, Volume: 170 | Tetrazole hybrids and their antifungal activities. |
| AID412145 | Antifungal activity against Candida krusei KCCM 11655 after 1 day | 2009 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 19, Issue:1 | Synthesis and antifungal activity of 1H-pyrrolo[3,2-g]quinoline-4,9-diones and 4,9-dioxo-4,9-dihydro-1H-benzo[f]indoles. |
| AID574608 | Antifungal activity against Candida albicans ATCC 44859 after 48 hrs by broth microdilution method | 2011 | Bioorganic & medicinal chemistry, Feb-15, Volume: 19, Issue:4 | Synthesis and antimycobacterial properties of N-substituted 6-amino-5-cyanopyrazine-2-carboxamides. |
| AID581895 | Antifungal activity against Candida albicans isolated from HSCT recipient 928 with acute or chronic GVHD mouth receiving antifungal drug after 112 days prophylaxis by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Impact of antifungal prophylaxis on colonization and azole susceptibility of Candida species. |
| AID457984 | Antifungal activity against Candida krusei ATCC 6258 after 48 hrs by microdilution method | 2010 | Bioorganic & medicinal chemistry, Mar-01, Volume: 18, Issue:5 | Antifungal 3,5-disubstituted furanones: From 5-acyloxymethyl to 5-alkylidene derivatives. |
| AID1628388 | Antimicrobial activity against Micrococcus luteus ATCC 4698 incubated for 24 hrs by NCCLS protocol based method | 2016 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 26, Issue:12 | Discovery of novel berberine imidazoles as safe antimicrobial agents by down regulating ROS generation. |
| AID279092 | Ratio of AUC in candidemia patient to MIC against Candida glabrata | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Association of fluconazole area under the concentration-time curve/MIC and dose/MIC ratios with mortality in nonneutropenic patients with candidemia. |
| AID1911623 | Antifungal activity against Candida krusei ATCC6258 assessed as fungal growth inhibition by broth microdilution assay | 2022 | Journal of medicinal chemistry, 06-09, Volume: 65, Issue:11 | Development of Lipo-γ-AA Peptides as Potent Antifungal Agents. |
| AID1918381 | Hepatotoxicity in mouse infected with Candida albicans assessed as plasma AST level at 20 mg/kg, ip administered on days 2,4,6,8,10,12 and measured on day 14 (Rvb = 53.4 +/-6.8 IU/L) | 2022 | Journal of medicinal chemistry, 11-10, Volume: 65, Issue:21 | Novel Aryl Alkamidazole Derivatives as Multifunctional Antifungal Inhibitors: Design, Synthesis, and Biological Evaluation. |
| AID622969 | Antifungal activity against Candida tropicalis 156 after 24 hrs by microdilution method | 2011 | Bioorganic & medicinal chemistry letters, Oct-15, Volume: 21, Issue:20 | Synthesis and biological activity of desmethoxy analogues of coruscanone A. |
| AID622974 | Antifungal activity against Candida lusitaniae 2446/I after 48 hrs by microdilution method | 2011 | Bioorganic & medicinal chemistry letters, Oct-15, Volume: 21, Issue:20 | Synthesis and biological activity of desmethoxy analogues of coruscanone A. |
| AID1193898 | Antifungal activity against Candida tropicalis MTCC 183 assessed as zone of inhibition at 5 mg/ml after 24 hrs by agar well diffusion method | 2015 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 25, Issue:7 | Rapid 'one-pot' synthesis of a novel benzimidazole-5-carboxylate and its hydrazone derivatives as potential anti-inflammatory and antimicrobial agents. |
| AID469173 | Antifungal activity against Candida tropicalis | 2010 | European journal of medicinal chemistry, Feb, Volume: 45, Issue:2 | Synthesis, anti-bacterial and anti-fungal activities of some novel Schiff bases containing 2,4-disubstituted thiazole ring. |
| AID1157294 | Antifungal activity against Cryptococcus neoformans 32609 assessed as growth inhibition by automatic microplate reader analysis | 2014 | Journal of natural products, May-23, Volume: 77, Issue:5 | Polyhydroxy cyclohexanols from a Dendrodochium sp. fungus associated with the sea cucumber Holothuria nobilis Selenka. |
| AID716247 | Antimicrobial activity against Candida albicans by microbroth dilution method | 2012 | European journal of medicinal chemistry, Sep, Volume: 55 | Synthesis and biological evaluation of novel benzimidazole derivatives and their binding behavior with bovine serum albumin. |
| AID1890284 | Antifungal activity against Aspergillus nidulans clinical isolate 2 assessed as reduction in fungal growth by broth dilution method | 2022 | Bioorganic & medicinal chemistry letters, 05-01, Volume: 63 | Novel 2-aryl-4-aryloxyquinoline-based fungistatics for Mucor circinelloides. Biological evaluation of activity, QSAR and docking study. |
| AID1494176 | Antifungal activity against fluconazole/ITC-resistant Candida albicans ATCC 90819 measured after 48 hrs by CLSI M27-A3 protocol based method | 2018 | Bioorganic & medicinal chemistry, 02-01, Volume: 26, Issue:3 | Novel fluconazole derivatives with promising antifungal activity. |
| AID453447 | Antifungal activity against Candida albicans ATCC 90028 after 48 hrs by broth microdilution method | 2010 | Bioorganic & medicinal chemistry letters, Jan-15, Volume: 20, Issue:2 | Fluconazole analogues containing 2H-1,4-benzothiazin-3(4H)-one or 2H-1,4-benzoxazin-3(4H)-one moieties, a novel class of anti-Candida agents. |
| AID367159 | Antimicrobial activity against Sporothrix schenckii by broth microdilution method | 2009 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 19, Issue:3 | Synthesis and antifungal activity of 1,2,3-triazole containing fluconazole analogues. |
| AID486426 | Antibacterial activity against Penicillium chrysogenum NCIM 707 after 72 hrs by disc diffusion method | 2010 | European journal of medicinal chemistry, Jun, Volume: 45, Issue:6 | Synthesis and biological evaluation of beta-chloro vinyl chalcones as inhibitors of TNF-alpha and IL-6 with antimicrobial activity. |
| AID1369498 | Induction of cell wall permeabilization in Candida albicans cgmcc 2.2086 assessed as increase in NPN uptake at 1 to 32 uM by fluorescence spectrophotometric method | 2018 | Journal of medicinal chemistry, 05-10, Volume: 61, Issue:9 | Combating Drug-Resistant Fungi with Novel Imperfectly Amphipathic Palindromic Peptides. |
| AID1885979 | Antifungal activity against Cryptococcus gattii E566 assessed as fungal growth inhibition incubated for 72 hrs in presence of P163-0892 by broth microdilution method | |||
| AID1254325 | Antifungal activity against Aspergillus fumigatus 231 after 48 hrs by microdilution broth method | 2015 | Bioorganic & medicinal chemistry, Nov-15, Volume: 23, Issue:22 | Novel derivatives of nitro-substituted salicylic acids: Synthesis, antimicrobial activity and cytotoxicity. |
| AID262555 | Antifungal activity against Trichophyton violaceum | 2006 | Journal of medicinal chemistry, Apr-20, Volume: 49, Issue:8 | Structure-based optimization of azole antifungal agents by CoMFA, CoMSIA, and molecular docking. |
| AID564265 | Effect on sterol composition in Candida albicans isolate 14 expressing wild type erg11 and erg5 assessed as obtusifoliol level after 2 hrs by gas chromatography | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | A clinical isolate of Candida albicans with mutations in ERG11 (encoding sterol 14alpha-demethylase) and ERG5 (encoding C22 desaturase) is cross resistant to azoles and amphotericin B. |
| AID619646 | Antifungal activity against Cryptococcus neoformans JEC-21 after 72 hrs by broth microdilution method | 2011 | Bioorganic & medicinal chemistry, Oct-01, Volume: 19, Issue:19 | Antifungal activity of a series of 1,2-benzisothiazol-3(2H)-one derivatives. |
| AID1598011 | Antifungal activity against Candida tropicalis | 2019 | European journal of medicinal chemistry, May-15, Volume: 170 | Current advances of triazole alcohols derived from fluconazole: Design, in vitro and in silico studies. |
| AID1886088 | Antifungal activity against Cryptococcus gattii WM178 infected in Wax moth larvae assessed as median survival time at 10 mg/kg measured after 9 days by Kaplan-Meier method | |||
| AID518441 | Antimicrobial activity against Cryptococcus gattii serotype B isolate NIH771 assessed as heteroresistant isolates at 4 ug/ml | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Heteroresistance of Cryptococcus gattii to fluconazole. |
| AID1904355 | Cytotoxicity against human THLE-2 cells assessed as reduction in cell viability incubated for 96 hrs by MTT assay | 2022 | European journal of medicinal chemistry, Apr-05, Volume: 233 | Design, synthesis, and evaluation of novel 3-thiophene derivatives as potent fungistatic and fungicidal reagents based on a conformational restriction strategy. |
| AID245421 | Minimum inhibitory concentration against Candida krusei 1766-1 evaluated by in vitro agar diffusion and micro-broth dilution assay | 2005 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 15, Issue:15 | Synthesis of some diguanidino 1-methyl-2,5-diaryl-1H-pyrroles as antifungal agents. |
| AID304968 | Antibacterial activity against Klebsiella pneumoniae by broth micro-dilution technique | 2007 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 17, Issue:1 | New antifungal flavonoid glycoside from Vitex negundo. |
| AID1609930 | Antifungal activity against fluconazole-resistant Candida albicans 17 assessed as reduction in fungal growth incubated for 24 hrs by serial dilution method | |||
| AID555134 | Antimicrobial activity against Candida glabrata by CLSI M27-A2 broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Fenticonazole activity measured by the methods of the European Committee on Antimicrobial Susceptibility Testing and CLSI against 260 Candida vulvovaginitis isolates from two European regions and annotations on the prevalent genotypes. |
| AID287828 | Antifungal activity against Trichosporon beigelii 1188 after 48 hrs | 2007 | Bioorganic & medicinal chemistry, Apr-15, Volume: 15, Issue:8 | Hybrid molecules of estrone: new compounds with potential antibacterial, antifungal, and antiproliferative activities. |
| AID9223 | In vitro antifungal activity against Aspergillus flavus CM74 | 2002 | Journal of medicinal chemistry, Oct-24, Volume: 45, Issue:22 | Synthesis, antifungal activity, and molecular modeling studies of new inverted oxime ethers of oxiconazole. |
| AID43008 | Inhibition of Candida tropicalis 156 growth for 24 hours in vitro. | 2001 | Journal of medicinal chemistry, Aug-16, Volume: 44, Issue:17 | 3-Phenyl-5-acyloxymethyl-2H,5H-furan-2-ones: synthesis and biological activity of a novel group of potential antifungal drugs. |
| AID609967 | Antifungal activity against Aspergillus niger at 500 ug after 24 hrs by paper disc technique relative to control | 2011 | Bioorganic & medicinal chemistry letters, Aug-15, Volume: 21, Issue:16 | Efficient synthesis of antifungal active 9-substituted-3-aryl-5H,13aH-quinolino[3,2-f][1,2,4]triazolo[4,3-b][1,2,4]triazepines in ionic liquids. |
| AID555330 | Antimicrobial activity against Candida krusei ATCC 6258 by EUCAST broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Fenticonazole activity measured by the methods of the European Committee on Antimicrobial Susceptibility Testing and CLSI against 260 Candida vulvovaginitis isolates from two European regions and annotations on the prevalent genotypes. |
| AID405023 | Antifungal activity against Sporothrix schenckii P30019 isolate from cutaneous-lymphatic sporotrichosis patient after 72 hrs by ATB Fungus 2 method | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | In vitro susceptibility of Sporothrix schenckii to six antifungal agents determined using three different methods. |
| AID622972 | Antifungal activity against Candida glabrata 20/I after 48 hrs by microdilution method | 2011 | Bioorganic & medicinal chemistry letters, Oct-15, Volume: 21, Issue:20 | Synthesis and biological activity of desmethoxy analogues of coruscanone A. |
| AID625773 | Antifungal activity against Cryptococcus neoformans 32609 after 72 hrs by serial dilution method | 2011 | European journal of medicinal chemistry, Nov, Volume: 46, Issue:11 | Design and synthesis of novel triazole antifungal derivatives by structure-based bioisosterism. |
| AID619177 | Antifungal activity against Candida albicans SCS 71865 L by broth dilution method | 2011 | Journal of medicinal chemistry, Oct-13, Volume: 54, Issue:19 | High-throughput-screening-based identification and structure-activity relationship characterization defined (S)-2-(1-aminoisobutyl)-1-(3-chlorobenzyl)benzimidazole as a highly antimycotic agent nontoxic to cell lines. |
| AID1279028 | Antifungal activity against Candida glabrata 20/I after 48 hrs by microbroth dilution method | 2016 | Bioorganic & medicinal chemistry, Mar-15, Volume: 24, Issue:6 | Salicylanilide N-monosubstituted carbamates: Synthesis and in vitro antimicrobial activity. |
| AID516267 | Antimicrobial activity against Cryptococcus gattii serotype B isolate NIH754 assessed as concentration required for heteroresistance | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Heteroresistance of Cryptococcus gattii to fluconazole. |
| AID567430 | Antifungal activity against Dipodascus capitatus after 48 hrs by Etest | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | In vitro antifungal activities of isavuconazole and comparators against rare yeast pathogens. |
| AID283233 | Reduction of fungal burden in Coccidioides immitis Silveira infected CD1 mouse lung and kidney administered after 3 days of infection at 10 mg/kg, po bid after 5 days relative to control | 2007 | Antimicrobial agents and chemotherapy, Mar, Volume: 51, Issue:3 | Comparison of itraconazole and fluconazole treatments in a murine model of coccidioidal meningitis. |
| AID531467 | Antifungal activity against Candida lusitaniae assessed as susceptible dose-dependent isolates after 48 hrs by CLSI method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | In vitro susceptibilities of invasive isolates of Candida species: rapid increase in rates of fluconazole susceptible-dose dependent Candida glabrata isolates. |
| AID323072 | Antifungal activity against Cryptococcus neoformans IM 972751 by microbroth dilution method | 2008 | Bioorganic & medicinal chemistry, Jan-15, Volume: 16, Issue:2 | Antifungal and cytotoxic activities of some N-substituted aniline derivatives bearing a hetaryl fragment. |
| AID1898151 | Antifungal activity against Candida albicans SC5314 incubated for 24 hrs by microbroth dilution method | |||
| AID521518 | Antifungal activity against Rhizopus oryzae NBRC 31005 after 24 hrs by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | In vitro and in vivo antifungal activities of T-2307, a novel arylamidine. |
| AID555009 | Antifungal activity against Candida humicola assessed as percent susceptible isolates at 25 ug/disc by CLSI M44-A disk diffusion method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | In vitro activities of fluconazole and voriconazole against clinical isolates of Candida spp. determined by disk diffusion testing in Turin, Italy. |
| AID1168328 | Binding affinity to human serum albumin at 302 K by modified Stern-Volmer method | 2014 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 24, Issue:21 | Study the interactions between human serum albumin and two antifungal drugs: fluconazole and its analogue DTP. |
| AID555012 | Antifungal activity against Candida lusitaniae assessed as percent susceptible isolates at 25 ug/disc by CLSI M44-A disk diffusion method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | In vitro activities of fluconazole and voriconazole against clinical isolates of Candida spp. determined by disk diffusion testing in Turin, Italy. |
| AID772323 | Antifungal activity against fluconazole-resistant Candida albicans DSY775 harboring ERG11 gene mutant and increase expressing of CDR1 and CDR2 genes after 24 hrs by visually and spectrophotometric analysis | 2013 | ACS medicinal chemistry letters, Sep-12, Volume: 4, Issue:9 | Novel Macrocyclic Amidinoureas: Potent Non-Azole Antifungals Active against Wild-Type and Resistant Candida Species. |
| AID1864881 | Antifungal activity against Aspergillus fumigatus KM8001 assessed as fungal growth inhibition measured after 72 hrs by double dilution method | |||
| AID1548541 | Antifungal activity against fluconazole-resistant Candida albicans assessed as growth inhibition measured after 24 hrs by CLSI protocol based broth microdilution method | 2020 | ACS medicinal chemistry letters, Apr-09, Volume: 11, Issue:4 | Azole Based Acetohydrazide Derivatives of Cinnamaldehyde Target and Kill |
| AID1822749 | Antifungal activity against fluconazole resistant Candida albicans 103 incubated for 48 hrs by CLSI based broth microdilution method | 2022 | Journal of medicinal chemistry, 02-10, Volume: 65, Issue:3 | Structure-Guided Discovery of the Novel Covalent Allosteric Site and Covalent Inhibitors of Fructose-1,6-Bisphosphate Aldolase to Overcome the Azole Resistance of |
| AID665132 | Antifungal activity against 2 strains of Candida sake after 24 hrs by EUCAST broth microdilution method | 2012 | European journal of medicinal chemistry, Jul, Volume: 53 | Synthesis, anti-Candida activity, and cytotoxicity of new (4-(4-iodophenyl)thiazol-2-yl)hydrazine derivatives. |
| AID1405040 | Antifungal activity against Candida parapsilosis ATCC 22019 after 24 hrs by two-fold broth microdilution assay | 2018 | European journal of medicinal chemistry, Jul-15, Volume: 155 | Novel carbazole-triazole conjugates as DNA-targeting membrane active potentiators against clinical isolated fungi. |
| AID670396 | Antifungal activity against Candida albicans MTCC 854 by well diffusion method | 2012 | Bioorganic & medicinal chemistry letters, Jul-15, Volume: 22, Issue:14 | Synthesis, biological evaluation of 5-carbomethoxymethyl-7-hydroxy-2-pentylchromone, 5-carboethoxymethyl-4',7-dihydroxyflavone and their analogues. |
| AID518171 | Antimicrobial activity against Cryptococcus gattii serotype B isolate NIH200 assessed as heteroresistant isolates at 2 ug/ml | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Heteroresistance of Cryptococcus gattii to fluconazole. |
| AID1246581 | Antifungal activity against Cryptococcus gattii 196L/03 after 48 to 72 hrs by broth microdilution method | 2015 | European journal of medicinal chemistry, Sep-18, Volume: 102 | Thiazole compounds with activity against Cryptococcus gattii and Cryptococcus neoformans in vitro. |
| AID590504 | Antifungal activity against Candida glabrata ATCC 36583 after 48 hrs | 2011 | European journal of medicinal chemistry, Apr, Volume: 46, Issue:4 | Synthesis, biopharmaceutical characterization, antimicrobial and antioxidant activities of 1-(4'-O-β-D-glucopyranosyloxy-2'-hydroxyphenyl)-3-aryl-propane-1,3-diones. |
| AID1762173 | Antifungal activity against Candida glabrata 61L assessed as reduction in fungal growth incubated for 48 hrs by CLSI based serial microbroth dilution method | 2021 | Bioorganic & medicinal chemistry letters, 05-15, Volume: 40 | Synthesis and antifungal activity of new hybrids thiazolo[4,5-d]pyrimidines with (1H-1,2,4)triazole. |
| AID1357631 | Antifungal activity against Candida albicans ATCC 18804 after 48 hrs by microbroth dilution assay | 2018 | European journal of medicinal chemistry, May-10, Volume: 151 | Synthesis, molecular modeling studies and evaluation of antifungal activity of a novel series of thiazole derivatives. |
| AID1494188 | Antifungal activity against Candida glabrata isolate CG3 measured after 48 hrs by CLSI M27-A3 protocol based method | 2018 | Bioorganic & medicinal chemistry, 02-01, Volume: 26, Issue:3 | Novel fluconazole derivatives with promising antifungal activity. |
| AID582249 | Antifungal activity against Candida albicans isolated from neutropenic subjects with AML or MDS prior to initiation of fluconazole therapy by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Impact of antifungal prophylaxis on colonization and azole susceptibility of Candida species. |
| AID1783102 | Antifungal activity against Cryptococcus neoformans H99 infected in ICR mouse model assessed as reduction in fungal burden in brain at 20 mg/kg, po administered once a day for 5 days | 2021 | European journal of medicinal chemistry, Oct-05, Volume: 221 | Lanosterol 14α-demethylase (CYP51)/histone deacetylase (HDAC) dual inhibitors for treatment of Candida tropicalis and Cryptococcus neoformans infections. |
| AID665069 | Antifungal activity against Candida parapsilosis after 24 hrs by serial dilution method | 2012 | European journal of medicinal chemistry, Jul, Volume: 53 | Design, synthesis and structure-activity relationships of new triazole derivatives containing N-substituted phenoxypropylamino side chains. |
| AID777330 | Antifungal activity against Trichophyton mentagrophytes isolated from patient assessed as growth inhibition after 72 to 96 hrs by microbroth dilution method | 2013 | ACS medicinal chemistry letters, Oct-10, Volume: 4, Issue:10 | Identification of 1-[4-Benzyloxyphenyl)-but-3-enyl]-1H-azoles as New Class of Antitubercular and Antimicrobial Agents. |
| AID608610 | Antimicrobial activity against Candida albicans ATCC 10231 after 24 hrs by microdilution technique | 2011 | European journal of medicinal chemistry, Jul, Volume: 46, Issue:7 | New condensed pyrroles of potential biological interest syntheses and structure-activity relationship studies. |
| AID1279026 | Antifungal activity against Candida krusei E28 after 48 hrs by microbroth dilution method | 2016 | Bioorganic & medicinal chemistry, Mar-15, Volume: 24, Issue:6 | Salicylanilide N-monosubstituted carbamates: Synthesis and in vitro antimicrobial activity. |
| AID1168344 | Ratio of binding constant for human serum albumin in presence of Ba2+ to binding constant for human serum albumin in absence of metal ions | 2014 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 24, Issue:21 | Study the interactions between human serum albumin and two antifungal drugs: fluconazole and its analogue DTP. |
| AID304970 | Antibacterial activity against Pseudomonas aeruginosa by broth micro-dilution technique | 2007 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 17, Issue:1 | New antifungal flavonoid glycoside from Vitex negundo. |
| AID1484686 | Leishmanicidal activity against Leishmania panamensis LS94 promastigote forms after 18 hrs by indirect microscopic analysis | 2017 | European journal of medicinal chemistry, Jul-28, Volume: 135 | An overview of azoles targeting sterol 14α-demethylase for antileishmanial therapy. |
| AID278382 | Antifungal activity against Candida lusitaniae 6936 URA3[D95V] derived null mutant fcy1delta::URA3 by microdilution assay | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Molecular mechanism of flucytosine resistance in Candida lusitaniae: contribution of the FCY2, FCY1, and FUR1 genes to 5-fluorouracil and fluconazole cross-resistance. |
| AID1472859 | Aqueous solubility of the compound | 2018 | Journal of medicinal chemistry, 01-11, Volume: 61, Issue:1 | Alkylated Piperazines and Piperazine-Azole Hybrids as Antifungal Agents. |
| AID1572483 | Antifungal activity against Candida albicans SC5314 after 48 hrs by serial dilution method | 2019 | Bioorganic & medicinal chemistry, 03-01, Volume: 27, Issue:5 | Discovery of novel simplified isoxazole derivatives of sampangine as potent anti-cryptococcal agents. |
| AID775474 | Antifungal activity against Candida albicans ATCC 10231 assessed as growth inhibition after 24 hrs by liquid dilution method | 2013 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 23, Issue:21 | Synthesis and antimicrobial activity of polyhalobenzonitrile quinazolin-4(3H)-one derivatives. |
| AID1497596 | Antifungal activity against fluconazole-susceptible Candida albicans isolate 97 after 24 hrs by broth microdilution method | 2018 | Bioorganic & medicinal chemistry letters, 07-15, Volume: 28, Issue:13 | Benzofuro[3,2-d]pyrimidines inspired from cercosporamide CaPkc1 inhibitor: Synthesis and evaluation of fluconazole susceptibility restoration. |
| AID279105 | Mortality rate in Candida lusitaniae infected candidemia patient | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Association of fluconazole area under the concentration-time curve/MIC and dose/MIC ratios with mortality in nonneutropenic patients with candidemia. |
| AID1413579 | Antifungal activity against Aspergillus fumigatus KM8001 by broth microdilution method | |||
| AID555007 | Antifungal activity against Candida norvegensis assessed as percent resistant isolates at 25 ug/disc by CLSI M44-A disk diffusion method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | In vitro activities of fluconazole and voriconazole against clinical isolates of Candida spp. determined by disk diffusion testing in Turin, Italy. |
| AID320385 | Antimicrobial activity against Cryptococcus neoformans NCL2 by broth microdilution method | 2008 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 18, Issue:6 | Synthesis and antimicrobial activity of beta-lactam-bile acid conjugates linked via triazole. |
| AID1557089 | Inhibition of recombinant human CYP3A4 using Luciferin-PPXE as substrate preincubated for 10 mins followed by NADPH addition measured after 15 mins by luminometric method | 2019 | European journal of medicinal chemistry, Oct-01, Volume: 179 | Antifungal activity, mode of action variability, and subcellular distribution of coumarin-based antifungal azoles. |
| AID521530 | Antifungal activity against Candida albicans clinical isolates after 48 hrs by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | In vitro and in vivo antifungal activities of T-2307, a novel arylamidine. |
| AID588218 | FDA HLAED, lactate dehydrogenase (LDH) increase | 2004 | Current drug discovery technologies, Dec, Volume: 1, Issue:4 | Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling. |
| AID666836 | Antifungal activity against Aspergillus terreus at 12.5 ug/ml after 72 hrs by well plate method | 2012 | European journal of medicinal chemistry, Aug, Volume: 54 | Synthesis, characterization and antimicrobial studies of some new quinoline incorporated benzimidazole derivatives. |
| AID325035 | Antimicrobial activity against Candida albicans SC5314 after 24 hrs by broth macrodilution method | 2007 | Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5 | A Candida albicans petite mutant strain with uncoupled oxidative phosphorylation overexpresses MDR1 and has diminished susceptibility to fluconazole and voriconazole. |
| AID691707 | Antifungal activity against Saccharomyces cerevisiae MTCC 172 after 24 hrs by serial dilution method | 2012 | Bioorganic & medicinal chemistry letters, Oct-15, Volume: 22, Issue:20 | Synthesis of β-ionone derived chalcones as potent antimicrobial agents. |
| AID1187442 | Antifungal activity against Candida glabrata after 24 hrs by serial dilution method | 2014 | Bioorganic & medicinal chemistry letters, Sep-01, Volume: 24, Issue:17 | Scaffold hopping of sampangine: discovery of potent antifungal lead compound against Aspergillus fumigatus and Cryptococcus neoformans. |
| AID497655 | Inhibition of mouse prion protein (89-230) assessed as inhibition of amyloid polymerization at 50 uM by thioflavin T fluorescence assay relative to untreated control | 2008 | Nature chemical biology, Mar, Volume: 4, Issue:3 | Small-molecule aggregates inhibit amyloid polymerization. |
| AID1728459 | Antifungal activity against Candida krusei ATCC 6258 assessed as inhibition of microbial growth by NCCLS protocol based method | 2021 | European journal of medicinal chemistry, Jan-15, Volume: 210 | Novel naphthylamide derivatives as dual-target antifungal inhibitors: Design, synthesis and biological evaluation. |
| AID1487495 | Antifungal activity against Aspergillus niger assessed as zone of inhibition at 100 ug/ml measured after 24 hrs by well diffusion method | 2017 | Bioorganic & medicinal chemistry letters, 08-15, Volume: 27, Issue:16 | Synthesis, antioxidant, antifungal, molecular docking and ADMET studies of some thiazolyl hydrazones. |
| AID750197 | Antifungal activity against Candida parapsilosis after 48 hrs by CLSI M27A3 broth microdilution method | 2013 | European journal of medicinal chemistry, Jun, Volume: 64 | Synthesis, antifungal and cytotoxic activities of 2-aryl-3-((piperidin-1-yl)ethyl)thiazolidinones. |
| AID1689818 | Antifungal activity against fluconazole-resistant Candida albicans DSY292 harboring Erg1l G464S/R467K/Y132 mutant assessed as reduction in microbial growth after 24 hrs by resazurin staining based spectrofluorometric method | 2020 | European journal of medicinal chemistry, Mar-01, Volume: 189 | New azole antifungals with a fused triazinone scaffold. |
| AID750769 | Antifungal activity against Aspergillus niger MTCC 1108 after 48 hrs | 2013 | European journal of medicinal chemistry, Jun, Volume: 64 | Biological activity, design, synthesis and structure activity relationship of some novel derivatives of curcumin containing sulfonamides. |
| AID301027 | Antifungal activity against Candida glabrata HO3 after 48 hrs by agar well diffusion technique | 2007 | Bioorganic & medicinal chemistry letters, Oct-01, Volume: 17, Issue:19 | Synthesis and antimicrobial evaluation of new chalcones containing piperazine or 2,5-dichlorothiophene moiety. |
| AID1487225 | Inhibition of CYP19 in human hepatocyte microsomes using testosterone substrate by HPLC/MS/MS method | 2017 | Bioorganic & medicinal chemistry letters, 08-01, Volume: 27, Issue:15 | Design and optimization of highly-selective, broad spectrum fungal CYP51 inhibitors. |
| AID493516 | Antifungal activity against Candida krusei E28 after 48 hrs by broth microdilution assay | 2010 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 20, Issue:15 | N-Benzylsalicylthioamides as novel compounds with promising antimycotic activity. |
| AID1235475 | Inhibition of ergosterol biosynthesis in Candida albicans ATCC 10261 assessed as ergosterol content after 16 hrs by spectrophotometer analysis | 2015 | Bioorganic & medicinal chemistry, Aug-01, Volume: 23, Issue:15 | Imidazole clubbed 1,3,4-oxadiazole derivatives as potential antifungal agents. |
| AID1758008 | Antifungal activity against Aspergillus fumigatus CMGCC3.7795 measured after 72 hrs by broth microdilution assay | 2021 | European journal of medicinal chemistry, Apr-15, Volume: 216 | Lead optimization generates selenium-containing miconazole CYP51 inhibitors with improved pharmacological profile for the treatment of fungal infections. |
| AID589643 | Antifungal activity against Cryptococcus neoformans | 2011 | European journal of medicinal chemistry, Apr, Volume: 46, Issue:4 | Synthesis of some novel 3-(1-(1-substitutedpiperidin-4-yl)-1H-1,2,3-triazol-4-yl)-5-substituted phenyl-1,2,4-oxadiazoles as antifungal agents. |
| AID1138331 | Antimicrobial activity against Candida glabrata 537 after 24 hrs by serial dilution method | 2014 | Journal of medicinal chemistry, May-08, Volume: 57, Issue:9 | Design, synthesis, and structure-activity relationship studies of novel fused heterocycles-linked triazoles with good activity and water solubility. |
| AID274921 | Cytotoxicity against Vero cells by neutral red method | 2006 | Journal of medicinal chemistry, Dec-28, Volume: 49, Issue:26 | Synthesis, antifungal activity, and structure-activity relationships of coruscanone A analogues. |
| AID561424 | Antifungal activity against Candida lusitaniae CL38-5 expressing URA3 gene by microdilution method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Nonsense and missense mutations in FCY2 and FCY1 genes are responsible for flucytosine resistance and flucytosine-fluconazole cross-resistance in clinical isolates of Candida lusitaniae. |
| AID1738702 | Antifungal activity against Candida zeylanoides CMGCC2.3739 measured after 24 hrs by micro-broth dilution assay | 2020 | European journal of medicinal chemistry, Jul-15, Volume: 198 | Design, synthesis, and biological evaluation of novel miconazole analogues containing selenium as potent antifungal agents. |
| AID407006 | Antimicrobial activity against Candida albicans FH1 dissociated biofilms at cell density of 10'8 cells/ml after 48 hrs by XTT assay | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | Role for cell density in antifungal drug resistance in Candida albicans biofilms. |
| AID1418534 | Cytotoxicity against human A549 cells by MTT assay | 2018 | Bioorganic & medicinal chemistry letters, 12-01, Volume: 28, Issue:22 | Design, synthesis, and biological evaluation of 4-chloro-2H-thiochromenes featuring nitrogen-containing side chains as potent antifungal agents. |
| AID519468 | Antimicrobial activity against Cryptococcus gattii by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | In Vitro activity of the new azole isavuconazole (BAL4815) compared with six other antifungal agents against 162 Cryptococcus neoformans isolates from Cuba. |
| AID1918338 | Antifungal activity against fluconazole-resistant Candida albicans CaR assessed as inhibition of fungal growth measured after 72 hrs by CLSI based liquid medium dilution method | 2022 | Journal of medicinal chemistry, 11-10, Volume: 65, Issue:21 | Novel Aryl Alkamidazole Derivatives as Multifunctional Antifungal Inhibitors: Design, Synthesis, and Biological Evaluation. |
| AID537735 | Binding affinity to Candida albicans CaMdr1p expressed in yeast AD1-8u | 2010 | European journal of medicinal chemistry, Nov, Volume: 45, Issue:11 | Analysis of physico-chemical properties of substrates of ABC and MFS multidrug transporters of pathogenic Candida albicans. |
| AID1409902 | Antifungal activity against Candida parapsilosis ATCC 22019 after 24 hrs by two-fold serial dilution method | |||
| AID444057 | Fraction escaping hepatic elimination in human | 2010 | Journal of medicinal chemistry, Feb-11, Volume: 53, Issue:3 | Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. |
| AID547604 | Antifungal activity against Candida glabrata isolate Cg17S | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | Microarray and molecular analyses of the azole resistance mechanism in Candida glabrata oropharyngeal isolates. |
| AID1348793 | Antifungal activity against Cryptococcus neoformans after 48 hrs by broth microdilution method | 2018 | European journal of medicinal chemistry, Jan-01, Volume: 143 | Substituted carbamothioic amine-1-carbothioic thioanhydrides as novel trichomonicidal fungicides: Design, synthesis, and biology. |
| AID1762151 | Antifungal activity against Candida albicans ATCC 24433 assessed as reduction in fungal growth incubated for 48 hrs by CLSI based serial microbroth dilution method | 2021 | Bioorganic & medicinal chemistry letters, 05-15, Volume: 40 | Synthesis and antifungal activity of new hybrids thiazolo[4,5-d]pyrimidines with (1H-1,2,4)triazole. |
| AID531245 | Antifungal activity against Candida krusei assessed as susceptible isolates after 48 hrs by CLSI method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | In vitro susceptibilities of invasive isolates of Candida species: rapid increase in rates of fluconazole susceptible-dose dependent Candida glabrata isolates. |
| AID406952 | Antifungal activity against Candida albicans ATCC 10261 at 35 degC after 48 to 96 hrs by broth microdilution test | 2008 | Journal of medicinal chemistry, Jul-10, Volume: 51, Issue:13 | 1-[(3-Aryloxy-3-aryl)propyl]-1H-imidazoles, new imidazoles with potent activity against Candida albicans and dermatophytes. Synthesis, structure-activity relationship, and molecular modeling studies. |
| AID1918391 | Anti-inflammatory activity in mouse infected with Candida albicans assessed as reduction in PD-L1 expression in spleen at 20 mg/kg, ip administered on days 2,4,6,8,10,12 and measured on day 14 by immunohistochemical analysis | 2022 | Journal of medicinal chemistry, 11-10, Volume: 65, Issue:21 | Novel Aryl Alkamidazole Derivatives as Multifunctional Antifungal Inhibitors: Design, Synthesis, and Biological Evaluation. |
| AID1506721 | Antibacterial activity against Staphylococcus aureus MTCC 96 by agar dilution method | 2017 | MedChemComm, Mar-01, Volume: 8, Issue:3 | Design, synthesis, molecular-docking and antimycobacterial evaluation of some novel 1,2,3-triazolyl xanthenones. |
| AID1770952 | Inhibition of CYP51 in Candida albicans assessed as Eburicol level at 0.25 ug/ml measured after 18 hrs by GC-MS analysis relative to control | 2021 | European journal of medicinal chemistry, Dec-05, Volume: 225 | Design, synthesis and evaluation of novel 5-phenylthiophene derivatives as potent fungicidal of Candida albicans and antifungal reagents of fluconazole-resistant fungi. |
| AID665134 | Antifungal activity against 4 strains of Candida tropicalis after 24 hrs by EUCAST broth microdilution method | 2012 | European journal of medicinal chemistry, Jul, Volume: 53 | Synthesis, anti-Candida activity, and cytotoxicity of new (4-(4-iodophenyl)thiazol-2-yl)hydrazine derivatives. |
| AID553856 | Antifungal activity against fluconazole resistant Candida albicans isolate B4 overexpressing MDR1 in RPMI-1640 buffered medium after 24 hrs by microdilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | Enhanced susceptibility to antifungal oligopeptides in yeast strains overexpressing ABC multidrug efflux pumps. |
| AID1898164 | Antifungal activity against Candida albicans 20# | |||
| AID1061243 | Antimicrobial activity against Chrysosporium keratinophilum at 0.5 mg/ml by well plate method | 2014 | European journal of medicinal chemistry, Jan, Volume: 71 | Synthesis and biological evaluation of novel substituted 1,3,4-thiadiazole and 2,6-di aryl substituted imidazo [2,1-b] [1,3,4] thiadiazole derivatives. |
| AID454197 | Antifungal activity against Aspergillus flavus NCIM 539 by standard agar plate method | 2010 | Bioorganic & medicinal chemistry letters, Jan-15, Volume: 20, Issue:2 | One pot synthesis and SAR of some novel 3-substituted 5,6-diphenyl-1,2,4-triazines as antifungal agents. |
| AID245491 | In vitro concentration required to inhibit 80% growth of Saccharomyces cerevisiae strain YEM139 (PDR5 deleted) after 48 h | 2004 | Bioorganic & medicinal chemistry letters, Oct-18, Volume: 14, Issue:20 | Quinazolinone-based fungal efflux pump inhibitors. Part 1: Discovery of an (N-methylpiperazine)-containing derivative with activity in clinically relevant Candida spp. |
| AID407020 | Antimicrobial activity against Chk1 deficient Candida albicans CHK21 dissociated biofilms at cell density of 10'3 cells/ml after 48 hrs by XTT assay | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | Role for cell density in antifungal drug resistance in Candida albicans biofilms. |
| AID419468 | Antifungal activity against Candida albicans CAI4 at 6 ug/disk after 24 hrs by disk diffusion assay | 2009 | Bioorganic & medicinal chemistry, Jun-01, Volume: 17, Issue:11 | Design, synthesis and evaluations of acridone derivatives using Candida albicans--search for MDR modulators led to the identification of an anti-candidiasis agent. |
| AID412146 | Antifungal activity against Cryptococcus neoformans KCCM 50564 after 1 day | 2009 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 19, Issue:1 | Synthesis and antifungal activity of 1H-pyrrolo[3,2-g]quinoline-4,9-diones and 4,9-dioxo-4,9-dihydro-1H-benzo[f]indoles. |
| AID622963 | Antifungal activity against Candida parapsilosis ATCC 22019 after 24 hrs by microdilution method | 2011 | Bioorganic & medicinal chemistry letters, Oct-15, Volume: 21, Issue:20 | Synthesis and biological activity of desmethoxy analogues of coruscanone A. |
| AID642909 | Antifungal activity against fluconazole-resistant Cryptococcus gattii ATCC 32609 | 2011 | ACS medicinal chemistry letters, May-12, Volume: 2, Issue:5 | Natural Product Based 6-Hydroxy-2,3,4,6-tetrahydropyrrolo[1,2-a]pyrimidinium Scaffold as A New Antifungal Template. |
| AID1154836 | Antifungal activity against fluconazole-resistant Candida albicans 100 after 24 hrs by serial dilution method | 2014 | ACS medicinal chemistry letters, May-08, Volume: 5, Issue:5 | Novel carboline derivatives as potent antifungal lead compounds: design, synthesis, and biological evaluation. |
| AID1235433 | Antifungal activity against clinical isolates of Candida albicans 2779 by broth microdilution assay | 2015 | Bioorganic & medicinal chemistry, Aug-01, Volume: 23, Issue:15 | Imidazole clubbed 1,3,4-oxadiazole derivatives as potential antifungal agents. |
| AID519047 | Antifungal activity against Candida krusei after 48 hrs by broth microdilution | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | Antimicrobial activity of omiganan pentahydrochloride against contemporary fungal pathogens responsible for catheter-associated infections. |
| AID1601668 | Antifungal activity against planktonic form of Candida albicans PMC 1082 by broth microdilution method | |||
| AID666845 | Antifungal activity against Aspergillus niger at 6.25 ug/ml after 72 hrs by well plate method | 2012 | European journal of medicinal chemistry, Aug, Volume: 54 | Synthesis, characterization and antimicrobial studies of some new quinoline incorporated benzimidazole derivatives. |
| AID1424746 | Antimicrobial activity against Candida albicans after 48 hrs by two-fold serial dilution method | 2018 | European journal of medicinal chemistry, May-25, Volume: 152 | New pyrazolopyridine analogs: Synthesis, antimicrobial, antiquorum-sensing and antitumor screening. |
| AID1783778 | Antifungal activity against fluconazole resistant Candida albicans CaR assessed as inhibition of fungal growth by NCCLS protocol based method | 2021 | European journal of medicinal chemistry, Nov-15, Volume: 224 | Improving the metabolic stability of antifungal compounds based on a scaffold hopping strategy: Design, synthesis, and structure-activity relationship studies of dihydrooxazole derivatives. |
| AID283228 | Effect on fungal burdens in Coccidioides immitis Silveira infected CD1 mouse lung administered after 3 days of infection at 50 mg/kg, po bid after 12 days | 2007 | Antimicrobial agents and chemotherapy, Mar, Volume: 51, Issue:3 | Comparison of itraconazole and fluconazole treatments in a murine model of coccidioidal meningitis. |
| AID1244344 | Antifungal activity against Sporothrix schenckii incubated for 48 hrs by broth micro-dilution method | 2015 | European journal of medicinal chemistry, Aug-28, Volume: 101 | N-Alkyl/aryl-4-(3-substituted-3-phenylpropyl)piperazine-1-carbothioamide as dual-action vaginal microbicides with reverse transcriptase inhibition. |
| AID1550455 | Antifungal activity against Candida parapsilosis ATCC 22019 assessed as decrease in fungal cell growth incubated for 24 hrs by E-test | 2019 | European journal of medicinal chemistry, Jun-01, Volume: 171 | Antimicrobial and KPC/AmpC inhibitory activity of functionalized benzosiloxaboroles. |
| AID1198413 | Anticandidal activity against Candida tropicalis ATCC 750 incubated at 37 degC for 24 hrs by broth dilution method | 2015 | European journal of medicinal chemistry, Mar-26, Volume: 93 | Synthesis, QSAR and anticandidal evaluation of 1,2,3-triazoles derived from naturally bioactive scaffolds. |
| AID1295978 | Antimicrobial activity against Candida tropicalis ATCC 75 after 24 hrs by two fold serial dilution method | 2016 | Journal of natural products, Feb-26, Volume: 79, Issue:2 | Antifungal Quinoline Alkaloids from Waltheria indica. |
| AID1329756 | Antifungal activity against Cladosporium cladosporioides ATCC 16022 after 48 hrs by broth microdilution method | |||
| AID48802 | Minimum concentration required to inhibit the growth of Candida tropicalis ATCC750 was determined | 2002 | Bioorganic & medicinal chemistry letters, Oct-07, Volume: 12, Issue:19 | Synthesis and evaluation of novel pyrrolidinyl sordaricin derivatives as antifungal agents. |
| AID351036 | Antimicrobial activity against Candida krusei after 72 hrs by broth microdilution method | 2009 | European journal of medicinal chemistry, Mar, Volume: 44, Issue:3 | 2-Acylhydrazino-5-arylpyrrole derivatives: synthesis and antifungal activity evaluation. |
| AID304973 | Antifungal activity against Cryptococcus neoformans by broth micro-dilution technique | 2007 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 17, Issue:1 | New antifungal flavonoid glycoside from Vitex negundo. |
| AID653254 | Antifungal activity against Candida albicans ATCC 09548 after 24 hrs by broth microdilution method | 2012 | Bioorganic & medicinal chemistry, Apr-15, Volume: 20, Issue:8 | Semisynthesis and antimicrobial activity of novel guttiferone-A derivatives. |
| AID1060492 | Antifungal activity against Candida albicans MTCC 183 by agar streak dilution method | 2014 | European journal of medicinal chemistry, Jan, Volume: 71 | Access to a new class of biologically active quinoline based 1,2,4-triazoles. |
| AID12540 | Plasma concentration expressed as area under curve after intravenous administration was determined in rat | 2002 | Bioorganic & medicinal chemistry letters, Feb-25, Volume: 12, Issue:4 | Design and synthesis of novel benzofurans as a new class of antifungal agents targeting fungal N-myristoyltransferase. Part 2. |
| AID1898196 | Inhibition of CYP51 in Candida albicans SC5314 assessed as eburicol level at 4 ug/ml measured after 12 hrs by GC-MS analysis (Rvb = 0.00%) | |||
| AID308609 | Antifungal activity against Trichophyton mentagrophytes | 2007 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 17, Issue:15 | Antifungal activity in triterpene glycosides from the sea cucumber Actinopyga lecanora. |
| AID584382 | Ratio of CDR1 gene expression in Candida glabrata isolated from patient 491 receiving antifungal drug to CDR1 gene expression in Candida glabrata isolated from patient 491 by RT-PCR analysis | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Impact of antifungal prophylaxis on colonization and azole susceptibility of Candida species. |
| AID704470 | Antifungal activity against Candida lusitaniae MY 1396 after 24 hrs by NCCLS broth microdilution method | 2012 | ACS medicinal chemistry letters, Oct-11, Volume: 3, Issue:10 | Antifungal spectrum, in vivo efficacy, and structure-activity relationship of ilicicolin h. |
| AID712901 | Antifungal activity against Aspergillus fumigatus after 72 hrs by broth dilution method | 2012 | European journal of medicinal chemistry, Aug, Volume: 54 | Synthesis and evaluation of antimicrobial activity of 4H-pyrimido[2,1-b]benzothiazole, pyrazole and benzylidene derivatives of curcumin. |
| AID1426256 | Antifungal activity against azole-resistant Candida albicans ATCC 64124 | 2017 | European journal of medicinal chemistry, Jan-27, Volume: 126 | Synthesis and bioactivity investigation of quinone-based dimeric cationic triazolium amphiphiles selective against resistant fungal and bacterial pathogens. |
| AID1584741 | Drug metabolism in rat liver microsome S9 fraction assessed as CYP450-mediated metabolism by measuring compound remaining at 5 uM pretreated with NADPH and measured after 30 mins by UPLC-MS/MS analysis | 2018 | Journal of medicinal chemistry, 10-25, Volume: 61, Issue:20 | Discovery of Novel 7-Aryl 7-Deazapurine 3'-Deoxy-ribofuranosyl Nucleosides with Potent Activity against Trypanosoma cruzi. |
| AID1707482 | Antifungal activity against Candida albicans 0304103 at 64 ug/ml incubated for 48 hrs by microdilution assay | 2021 | Journal of medicinal chemistry, 01-28, Volume: 64, Issue:2 | Novel Carboline Fungal Histone Deacetylase (HDAC) Inhibitors for Combinational Treatment of Azole-Resistant Candidiasis. |
| AID582998 | Antimicrobial activity against Saccharomyces cerevisiae YUG37 transformed with plasmid carrying cyp51A gene with doxycycline-regulatable promoter by broth dilution method in presence of doxycycline | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | Complementation of a Saccharomyces cerevisiae ERG11/CYP51 (sterol 14α-demethylase) doxycycline-regulated mutant and screening of the azole sensitivity of Aspergillus fumigatus isoenzymes CYP51A and CYP51B. |
| AID574609 | Antifungal activity against Candida tropicalis 156 after 48 hrs by broth microdilution method | 2011 | Bioorganic & medicinal chemistry, Feb-15, Volume: 19, Issue:4 | Synthesis and antimycobacterial properties of N-substituted 6-amino-5-cyanopyrazine-2-carboxamides. |
| AID1877293 | Antifungal activity against FLC-resistant Candida albicans 311 assessed as fungal growth inhibition by NCCLS protocol based method | 2022 | European journal of medicinal chemistry, Jan-05, Volume: 227 | Broadening antifungal spectrum and improving metabolic stablity based on a scaffold strategy: Design, synthesis, and evaluation of novel 4-phenyl-4,5-dihydrooxazole derivatives as potent fungistatic and fungicidal reagents. |
| AID521795 | Fungistatic activity against Candida glabrata isolate 4198 assessed as 99.9% reduction of initial fungal load at 8 times MIC after 48 hrs using colony count method by time-kill method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Posaconazole against Candida glabrata isolates with various susceptibilities to fluconazole. |
| AID736601 | Antifungal activity against fluconazole-resistant Candida glabrata isolate 6258 assessed as growth inhibition after 24 to 48 hrs by CLSI microbroth dilution method | 2013 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 23, Issue:6 | Synthesis and anti-Candida activity of novel 2-hydrazino-1,3-thiazole derivatives. |
| AID1549160 | Inhibition of CYP51 in azole-resistant Candida albicans 0304103 assessed as unknown sterol 5 level at 0.5 ug/ml after 24 hrs by GC-MS analysis (Rvb = 4.87%) | 2020 | Journal of medicinal chemistry, 05-28, Volume: 63, Issue:10 | Discovery of Novel Fungal Lanosterol 14α-Demethylase (CYP51)/Histone Deacetylase Dual Inhibitors to Treat Azole-Resistant Candidiasis. |
| AID518445 | Antimicrobial activity against Cryptococcus gattii serotype B isolate B5765 assessed as heteroresistant isolates at 4 ug/ml | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Heteroresistance of Cryptococcus gattii to fluconazole. |
| AID289662 | Antimicrobial activity against Salmonella typhi at 400 ug/ml after 48 hrs by disc-diffusion assay | 2007 | Bioorganic & medicinal chemistry letters, Jan-15, Volume: 17, Issue:2 | N/C-4 substituted azetidin-2-ones: synthesis and preliminary evaluation as new class of antimicrobial agents. |
| AID554710 | Antimicrobial activity against Candida krusei NZCDC 90.147 after 48 hrs by liquid microdilution assay | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Abc1p is a multidrug efflux transporter that tips the balance in favor of innate azole resistance in Candida krusei. |
| AID1179572 | Antibacterial activity against methicillin-resistant Staphylococcus aureus by NCCLS method | 2014 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 24, Issue:15 | Synthesis and SAR study of novel anticancer and antimicrobial naphthoquinone amide derivatives. |
| AID1584749 | Drug metabolism in dog liver microsome S9 fraction assessed as CYP450-mediated metabolism by measuring compound remaining at 5 uM pretreated with NADPH and measured after 60 mins by UPLC-MS/MS analysis | 2018 | Journal of medicinal chemistry, 10-25, Volume: 61, Issue:20 | Discovery of Novel 7-Aryl 7-Deazapurine 3'-Deoxy-ribofuranosyl Nucleosides with Potent Activity against Trypanosoma cruzi. |
| AID283200 | Susceptibility of polyene-resistant Candida glabrata 21229 isolate at 15 ug by disk diffusion method | 2007 | Antimicrobial agents and chemotherapy, Mar, Volume: 51, Issue:3 | Reduced susceptibility to polyenes associated with a missense mutation in the ERG6 gene in a clinical isolate of Candida glabrata with pseudohyphal growth. |
| AID367157 | Antimicrobial activity against Candida albicans by broth microdilution method | 2009 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 19, Issue:3 | Synthesis and antifungal activity of 1,2,3-triazole containing fluconazole analogues. |
| AID1886106 | Cytotoxicity against human Caco-2 cells assessed as cell viability at 256 ug/ml incubated for 24 hrs by CCK-8 assay | |||
| AID1168329 | Binding affinity to human serum albumin at 310 K by modified Stern-Volmer method | 2014 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 24, Issue:21 | Study the interactions between human serum albumin and two antifungal drugs: fluconazole and its analogue DTP. |
| AID1427207 | Antifungal activity against Trichosporon asahii 1188 after 48 hrs by microdilution broth assay | 2017 | Bioorganic & medicinal chemistry, 03-15, Volume: 25, Issue:6 | Antimicrobial activity of rhodanine-3-acetic acid derivatives. |
| AID1898190 | Inhibition of CYP51 in Candida albicans SC5314 assessed as lanosterol level at 4 ug/ml measured after 12 hrs by GC-MS analysis (Rvb = 2.18%) | |||
| AID1063949 | Antifungal activity against Trichosporon asahii 1188 after 48 hrs by broth microdilution method | 2014 | Bioorganic & medicinal chemistry, Jan-15, Volume: 22, Issue:2 | Salicylanilide diethyl phosphates: synthesis, antimicrobial activity and cytotoxicity. |
| AID555579 | Antimicrobial activity against Candida intermedia by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Activity profile in vitro of micafungin against Spanish clinical isolates of common and emerging species of yeasts and molds. |
| AID1557076 | Antifungal activity against Candida albicans P-87 assessed as reduction in fungal cell growth incubated for 24 hrs by MTT based broth double dilution method | 2019 | European journal of medicinal chemistry, Oct-01, Volume: 179 | Antifungal activity, mode of action variability, and subcellular distribution of coumarin-based antifungal azoles. |
| AID417550 | Antifungal activity against fluconazole-resistant Candida albicans 22009 | 2009 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 19, Issue:5 | FR290581, a novel sordarin derivative: synthesis and antifungal activity. |
| AID1370736 | Antifungal activity against Candida albicans SC5314 after 24 hrs by serial dilution method | 2018 | Bioorganic & medicinal chemistry letters, 02-01, Volume: 28, Issue:3 | Design, synthesis, and structure-activity relationship studies of novel tetrazole antifungal agents with potent activity, broad antifungal spectrum and high selectivity. |
| AID294850 | Antifungal activity against Candida tropicalis after 7 days by micro-broth dilution method | 2007 | European journal of medicinal chemistry, Sep, Volume: 42, Issue:9 | Synthesis of novel triazole derivatives as inhibitors of cytochrome P450 14alpha-demethylase (CYP51). |
| AID1885975 | Antifungal activity against Cryptococcus neoformans clinical isolate 445 assessed as fungal growth inhibition incubated for 72 hrs by broth microdilution method | |||
| AID1886031 | Synergistic antifungal activity against Cryptococcus gattii WM179 assessed as fractional inhibitory concentration index incubated for 72 hrs in presence of P163-0892 by broth microdilution method | |||
| AID486713 | Antifungal activity against Candida glabrata ATCC 3916 after 24 hrs by macrodilution method | 2010 | European journal of medicinal chemistry, Jun, Volume: 45, Issue:6 | Design, synthesis and determination of antifungal activity of 5(6)-substituted benzotriazoles. |
| AID1274474 | Antifungal activity against Aspergillus fumigatus GIMCC 3.19 after 24 hrs by two-fold serial dilution method | 2016 | European journal of medicinal chemistry, Jan-27, Volume: 108 | Synthesis and biological evaluation of novel phosphoramidate derivatives of coumarin as chitin synthase inhibitors and antifungal agents. |
| AID1628391 | Antimicrobial activity against beer yeast ATCC 9763 incubated for 24 hrs by NCCLS protocol based method | 2016 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 26, Issue:12 | Discovery of novel berberine imidazoles as safe antimicrobial agents by down regulating ROS generation. |
| AID1738748 | Inhibition of CYP51 in azole-resistant Candida albicans ATCC SC531 assessed as inhibition of ergosterol biosynthesis by measuring ergosterol content at 8 ug/ml incubated for 16 hrs by LC-MS analysis relative to control | 2020 | European journal of medicinal chemistry, Jul-15, Volume: 198 | Design, synthesis, and biological evaluation of novel miconazole analogues containing selenium as potent antifungal agents. |
| AID1822750 | Antifungal activity against fluconazole resistant Candida albicans 7781 incubated for 48 hrs by CLSI based broth microdilution method | 2022 | Journal of medicinal chemistry, 02-10, Volume: 65, Issue:3 | Structure-Guided Discovery of the Novel Covalent Allosteric Site and Covalent Inhibitors of Fructose-1,6-Bisphosphate Aldolase to Overcome the Azole Resistance of |
| AID392372 | Antifungal activity against Trichosporon beigelii 1188 after 48 hrs by broth microdilution method | 2009 | Bioorganic & medicinal chemistry letters, Jan-15, Volume: 19, Issue:2 | Salicylanilide esters of N-protected amino acids as novel antimicrobial agents. |
| AID1904373 | Inhibition of CYP51 in Candida albicans ATCC SC5314 assessed as ergosterol level at 0.25 ug/ml measured after 18 hrs by GC-MS analysis (Rvb = 96.93 %) | 2022 | European journal of medicinal chemistry, Apr-05, Volume: 233 | Design, synthesis, and evaluation of novel 3-thiophene derivatives as potent fungistatic and fungicidal reagents based on a conformational restriction strategy. |
| AID540211 | Fraction unbound in human after iv administration | 2008 | Drug metabolism and disposition: the biological fate of chemicals, Jul, Volume: 36, Issue:7 | Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. |
| AID518443 | Antimicrobial activity against Cryptococcus gattii serotype B isolate B5788 assessed as heteroresistant isolates at 4 ug/ml | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Heteroresistance of Cryptococcus gattii to fluconazole. |
| AID1864935 | Induction of apoptosis in Candida albicans ATCC SC5314 assessed as normal cells incuabted for 24 hrs by V-FITC/PI staining based flow cytometry analysis (Rvb = 96.78%) | |||
| AID754916 | Antifungal activity against Trichophyton mentagrophytes 445 assessed as growth inhibition after 72 to 120 hrs by microbroth dilution method | 2013 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 23, Issue:12 | Synthesis and antimycobacterial evaluation of N-substituted 5-chloropyrazine-2-carboxamides. |
| AID457986 | Antifungal activity against Candida krusei E28 after 48 hrs by microdilution method | 2010 | Bioorganic & medicinal chemistry, Mar-01, Volume: 18, Issue:5 | Antifungal 3,5-disubstituted furanones: From 5-acyloxymethyl to 5-alkylidene derivatives. |
| AID655580 | Antifungal activity against Candida albicans SC5314 after 24 hrs by microbroth dilution method | 2012 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 22, Issue:8 | New triazole derivatives as antifungal agents: synthesis via click reaction, in vitro evaluation and molecular docking studies. |
| AID775728 | Antifungal activity against Aspergillus flavus assessed as growth inhibition after 48 to 72 hrs by broth microdilution method | 2013 | European journal of medicinal chemistry, Nov, Volume: 69 | Microwave assisted synthesis of dihydrobenzo[4,5]imidazo[1,2-a]pyrimidin-4-ones; synthesis, in vitro antimicrobial and anticancer activities of novel coumarin substituted dihydrobenzo[4,5]imidazo[1,2-a]pyrimidin-4-ones. |
| AID644834 | Antifungal activity against Candida parapsilosis after 48 hrs by M27-A3 CLSI method | 2012 | European journal of medicinal chemistry, Mar, Volume: 49 | Synthesis and antifungal activity of a new series of 2-(1H-imidazol-1-yl)-1-phenylethanol derivatives. |
| AID678587 | Antifungal activity against Aspergillus niger KCTC 1231 after 2 days by twofold broth dilution method | 2012 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 22, Issue:18 | Synthesis and antifungal activity of 1-thia-4b-aza-cyclopenta[b]fluorene-4,10-diones. |
| AID1471218 | Antifungal activity against Candida parapsilosis ATCC 22019 by spectrophotometric method | 2017 | Bioorganic & medicinal chemistry letters, 07-01, Volume: 27, Issue:13 | Diversity-oriented sustainable synthesis of antimicrobial spiropyrrolidine/thiapyrrolizidine oxindole derivatives: New ligands for a metallo-β-lactamase from Klebsiella pneumonia. |
| AID1168323 | Binding affinity to human serum albumin at 0.4 to 5.6 x 10' -5 M by UV-Vis spectroscopy | 2014 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 24, Issue:21 | Study the interactions between human serum albumin and two antifungal drugs: fluconazole and its analogue DTP. |
| AID1246579 | Antifungal activity against Cryptococcus gattii 547/OTTI-97-PI-10 after 48 to 72 hrs by broth microdilution method | 2015 | European journal of medicinal chemistry, Sep-18, Volume: 102 | Thiazole compounds with activity against Cryptococcus gattii and Cryptococcus neoformans in vitro. |
| AID564267 | Effect on sterol composition in Candida albicans isolate 14 expressing wild type erg11 and erg5 assessed as eburicol level after 2 hrs by gas chromatography | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | A clinical isolate of Candida albicans with mutations in ERG11 (encoding sterol 14alpha-demethylase) and ERG5 (encoding C22 desaturase) is cross resistant to azoles and amphotericin B. |
| AID480478 | Antifungal activity against Cryptococcus neoformans after 72 hrs by serial dilution method | 2010 | Bioorganic & medicinal chemistry letters, May-01, Volume: 20, Issue:9 | Structure-based rational design, synthesis and antifungal activity of oxime-containing azole derivatives. |
| AID1391390 | Antifungal activity against Candida tropicalis after 24 hrs by two fold serial dilution method | 2018 | Bioorganic & medicinal chemistry letters, 05-15, Volume: 28, Issue:9 | Novel purine benzimidazoles as antimicrobial agents by regulating ROS generation and targeting clinically resistant Staphylococcus aureus DNA groove. |
| AID545715 | Antifungal activity against Candida tropicalis after 24 hrs by serial dilution method | 2010 | European journal of medicinal chemistry, Dec, Volume: 45, Issue:12 | Novel conformationally restricted triazole derivatives with potent antifungal activity. |
| AID1330185 | Antibacterial activity against Staphylococcus aureus 503 measured after 24 hrs by two-fold serial dilution method | 2016 | Bioorganic & medicinal chemistry letters, 12-15, Volume: 26, Issue:24 | Synthesis and biological evaluation of chalcone derivatives containing aminoguanidine or acylhydrazone moieties. |
| AID1516901 | Antifungal activity against Trichophyton rubrum deltaTruMDR2 by CLSI-based microdilution method | 2019 | Bioorganic & medicinal chemistry letters, 10-01, Volume: 29, Issue:19 | Recent advances in natural antifungal flavonoids and their derivatives. |
| AID1193497 | Thermodynamic equilibrium solubility, log S of the compound PBS at pH 7.4 at RT after 24 hrs by shake-flask method | 2015 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 25, Issue:7 | Thermodynamic equilibrium solubility measurements in simulated fluids by 96-well plate method in early drug discovery. |
| AID424660 | Antimicrobial activity against azole-resistant Candida albicans isolate CA10 assessed as growth at 0.125 ug/ml co-treated with 0.031 ug/ml calcineurin signaling inhibitor tacrolimus after 48 hrs by microdilution checkboard technique relative to control | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | In vitro interactions between tacrolimus and azoles against Candida albicans determined by different methods. |
| AID518890 | Antimicrobial activity against Cryptococcus gattii serotype C isolate H0058-1-2023 assessed as heteroresistant isolates at 32 ug/ml | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Heteroresistance of Cryptococcus gattii to fluconazole. |
| AID1549138 | Antifungal activity against azole-resistant Candida albicans 7781 after 48 hrs by spectrophotometry-based serial microdilution method | 2020 | Journal of medicinal chemistry, 05-28, Volume: 63, Issue:10 | Discovery of Novel Fungal Lanosterol 14α-Demethylase (CYP51)/Histone Deacetylase Dual Inhibitors to Treat Azole-Resistant Candidiasis. |
| AID1890266 | Antifungal activity against Mucor circinelloides M5 strain assessed as reduction in spore germination at 25 ug/ml relative to control | 2022 | Bioorganic & medicinal chemistry letters, 05-01, Volume: 63 | Novel 2-aryl-4-aryloxyquinoline-based fungistatics for Mucor circinelloides. Biological evaluation of activity, QSAR and docking study. |
| AID1551296 | Antifungal activity against Candida albicans 7535 assessed as reduction in bacterial cell growth incubated for 24 hrs by ELISA | 2019 | European journal of medicinal chemistry, Jun-15, Volume: 172 | Synthesis and biological evaluation of tryptophan-derived rhodanine derivatives as PTP1B inhibitors and anti-bacterial agents. |
| AID1743171 | Antifungal activity against Epidermophyton floccosum | 2020 | European journal of medicinal chemistry, Dec-15, Volume: 208 | Multiple biological active 4-aminopyrazoles containing trifluoromethyl and their 4-nitroso-precursors: Synthesis and evaluation. |
| AID405075 | Antifungal activity against Sporothrix schenckii isolate from cutaneous-lymphatic sporotrichosis patient after 72 hrs by modified NCCLS M38-A method | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | In vitro susceptibility of Sporothrix schenckii to six antifungal agents determined using three different methods. |
| AID515012 | Antifungal activity against Candida tropicalis by micro-broth dilution method | 2010 | European journal of medicinal chemistry, Oct, Volume: 45, Issue:10 | Synthesis and antifungal evaluation of novel triazole derivatives as inhibitors of cytochrome P450 14alpha-demethylase. |
| AID519054 | Antifungal activity against Penicillium marneffei after 48 hrs by broth microdilution | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | Antimicrobial activity of omiganan pentahydrochloride against contemporary fungal pathogens responsible for catheter-associated infections. |
| AID279088 | Antimicrobial activity against Candida parapsilosis at 24 hrs | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Association of fluconazole area under the concentration-time curve/MIC and dose/MIC ratios with mortality in nonneutropenic patients with candidemia. |
| AID561635 | Antimicrobial activity against Streptomyces platensis at 8 to 32 ug/ml | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Heteroresistance to fluconazole in Cryptococcus neoformans is intrinsic and associated with virulence. |
| AID582243 | Antifungal activity against Candida glabrata isolated from HSCT recipients with acute or chronic GVHD receiving fluconazole by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Impact of antifungal prophylaxis on colonization and azole susceptibility of Candida species. |
| AID1168351 | Ratio of binding constant for human serum albumin in presence of Cr3+ to binding constant for human serum albumin in absence of metal ions | 2014 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 24, Issue:21 | Study the interactions between human serum albumin and two antifungal drugs: fluconazole and its analogue DTP. |
| AID1180303 | Antimicrobial activity against Aspergillus niger NCIM-1196 after 20 hrs by two fold serial macrodilution technique | 2014 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 24, Issue:15 | One pot three components microwave assisted and conventional synthesis of new 3-(4-chloro-2-hydroxyphenyl)-2-(substituted) thiazolidin-4-one as antimicrobial agents. |
| AID1689229 | Antibacterial activity against Lactobacillus casei HM-334 assessed as reduction in bacterial growth by CLSI based assay | 2020 | European journal of medicinal chemistry, Mar-01, Volume: 189 | Oxadiazolylthiazoles as novel and selective antifungal agents. |
| AID1822755 | Antibiofilm activity against azole resistant Candida albicans 0304103 assessed as inhibition of biofilm formation by XTT assay | 2022 | Journal of medicinal chemistry, 02-10, Volume: 65, Issue:3 | Structure-Guided Discovery of the Novel Covalent Allosteric Site and Covalent Inhibitors of Fructose-1,6-Bisphosphate Aldolase to Overcome the Azole Resistance of |
| AID519062 | Antifungal activity against Candida glabrata assessed as resistant isolates after 48 hrs by broth microdilution | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | Antimicrobial activity of omiganan pentahydrochloride against contemporary fungal pathogens responsible for catheter-associated infections. |
| AID1265640 | Antifungal activity against Candida albicans clinical isolate after 24 hrs by sabouraud dextrose broth based microdilution method | 2016 | European journal of medicinal chemistry, Jan-01, Volume: 107 | Anti-Candida activity and cytotoxicity of a large library of new N-substituted-1,3-thiazolidin-4-one derivatives. |
| AID665066 | Antitubercular activity against Mycobacterium tuberculosis H37Rv at > 256 ug/mL | 2012 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 22, Issue:11 | An efficient one-pot synthesis, structure, antimicrobial and antioxidant investigations of some novel quinolyldibenzo[b,e][1,4]diazepinones. |
| AID1235461 | Antifungal activity against clinical isolates of Candida albicans 2779 after 48 hrs by disc diffusion assay | 2015 | Bioorganic & medicinal chemistry, Aug-01, Volume: 23, Issue:15 | Imidazole clubbed 1,3,4-oxadiazole derivatives as potential antifungal agents. |
| AID561631 | Antimicrobial activity against Cryptococcus neoformans serotype D | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Heteroresistance to fluconazole in Cryptococcus neoformans is intrinsic and associated with virulence. |
| AID1783074 | Antifungal activity against Candida tropicalis 5008 assessed as inhibition of fungal filamentation by measuring reduction in hyphae formation at 8 ug/ml incubated for 7 hrs by cell inverted imaging microscopic analysis | 2021 | European journal of medicinal chemistry, Oct-05, Volume: 221 | Lanosterol 14α-demethylase (CYP51)/histone deacetylase (HDAC) dual inhibitors for treatment of Candida tropicalis and Cryptococcus neoformans infections. |
| AID1911664 | Effect on MDR1 gene transcription level in Candida albicans CARG5 at 8 ug/ml incubated for 3 hrs by qRT-PCR analysis | 2022 | Journal of medicinal chemistry, 06-09, Volume: 65, Issue:11 | Development of Lipo-γ-AA Peptides as Potent Antifungal Agents. |
| AID310103 | Antifungal activity against Cryptococcus neoformans by disc diffusion method | 2007 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 17, Issue:22 | Synthesis and antimicrobial activity of some novel nucleoside analogues of adenosine and 1,3-dideazaadenosine. |
| AID369387 | Antimicrobial activity against Candida inconspicua isolate | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | In vitro susceptibility to posaconazole of 1,903 yeast isolates recovered in France from 2003 to 2006 and tested by the method of the European committee on antimicrobial susceptibility testing. |
| AID526816 | Antifungal activity against Candida tropicalis IAM 4965 assessed as concentration required to 50% growth inhibition using alamar blue staining after 18 to 72 hrs by microdilution method | 2010 | Bioorganic & medicinal chemistry, Nov-01, Volume: 18, Issue:21 | 1,3-Benzoxazole-4-carbonitrile as a novel antifungal scaffold of β-1,6-glucan synthesis inhibitors. |
| AID45328 | Evaluation of In vitro antifungal activity against Candida albicans ATCC 10231 by broth macro dilution method | 1995 | Journal of medicinal chemistry, Sep-29, Volume: 38, Issue:20 | Synthesis and antifungal activity of new azole derivatives containing an N-acylmorpholine ring. |
| AID555022 | Antifungal activity against Candida norvegensis by reference dilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | In vitro activities of fluconazole and voriconazole against clinical isolates of Candida spp. determined by disk diffusion testing in Turin, Italy. |
| AID294852 | Antifungal activity against Aspergillus fumigatus after 7 days by micro-broth dilution method | 2007 | European journal of medicinal chemistry, Sep, Volume: 42, Issue:9 | Synthesis of novel triazole derivatives as inhibitors of cytochrome P450 14alpha-demethylase (CYP51). |
| AID1820672 | Inhibition of CYP51 in Candida albicans SC5314 assessed as unknown sterol level at 0.25 ug/ml measured after 18 hrs by GC-MS analysis | 2022 | European journal of medicinal chemistry, Jan-15, Volume: 228 | Design, synthesis, and biological activity evaluation of 2-(benzo[b]thiophen-2-yl)-4-phenyl-4,5-dihydrooxazole derivatives as broad-spectrum antifungal agents. |
| AID1861417 | Antifungal activity against fluconazole-sensitive Candida albicans SC5314 assessed as inhibition of fungal growth by microdilution method | 2022 | Bioorganic & medicinal chemistry letters, 09-01, Volume: 71 | Discovery of novel indole and indoline derivatives against Candida albicans as potent antifungal agents. |
| AID547545 | Antifungal activity against Cryptococcus neoformans after 24 to 72 hrs by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | In vitro antifungal activities of bis(alkylpyridinium)alkane compounds against pathogenic yeasts and molds. |
| AID619171 | Antifungal activity against Issatchenkia orientalis ATCC 6258 by broth dilution method | 2011 | Journal of medicinal chemistry, Oct-13, Volume: 54, Issue:19 | High-throughput-screening-based identification and structure-activity relationship characterization defined (S)-2-(1-aminoisobutyl)-1-(3-chlorobenzyl)benzimidazole as a highly antimycotic agent nontoxic to cell lines. |
| AID567437 | Antifungal activity against Trichosporon inkin after 48 hrs by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | In vitro antifungal activities of isavuconazole and comparators against rare yeast pathogens. |
| AID405051 | Antifungal activity against Sporothrix schenckii PGAC0016 isolate from cutaneous-lymphatic sporotrichosis patient after 72 hrs by modified NCCLS M38-A method | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | In vitro susceptibility of Sporothrix schenckii to six antifungal agents determined using three different methods. |
| AID750758 | Antifungal activity against Trichoderma viride MTCC 1107 assessed as zone of inhibition at 20 uM after 48 hrs by disc diffusion method | 2013 | European journal of medicinal chemistry, Jun, Volume: 64 | Biological activity, design, synthesis and structure activity relationship of some novel derivatives of curcumin containing sulfonamides. |
| AID1864947 | Antiinflammatory activity against mouse infected with Candida albicans ATCC SC5314 assessed as reduction in COX-2 expression in spleen by Western blot analysis | |||
| AID1886090 | Antifungal activity against Cryptococcus gattii WM178 infected in Wax moth larvae assessed as survival rate at 10 mg/kg measured after 9 days in presence of P163-0892 by Kaplan-Meier method | |||
| AID1864876 | Antifungal activity against Cryptococcus neoformans ZKCC 2209 assessed as fungal growth inhibition measured after 72 hrs by double dilution method | |||
| AID564271 | Antifungal activity against Candida albicans isolate 177 after 48 hrs by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | A clinical isolate of Candida albicans with mutations in ERG11 (encoding sterol 14alpha-demethylase) and ERG5 (encoding C22 desaturase) is cross resistant to azoles and amphotericin B. |
| AID737319 | Antimicrobial activity against Aspergillus flavus MTCC 1973 at 1000 ug/ml after 72 hrs by cup plate method | 2013 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 23, Issue:7 | Synthesis of novel 2-amino-4-(5'-substituted 2'-phenyl-1H-indol-3'-yl)-6-aryl-4H-pyran-3-carbonitrile derivatives as antimicrobial and antioxidant agents. |
| AID1472819 | Antifungal activity against itraconazole and fluconazole resistant Candida albicans ATCC MYA-1003 after 48 hrs by broth dilution method | 2018 | Journal of medicinal chemistry, 01-11, Volume: 61, Issue:1 | Alkylated Piperazines and Piperazine-Azole Hybrids as Antifungal Agents. |
| AID470600 | Antifungal activity against Aspergillus fumigatus AF-27 after 72 hrs by microbroth dilution technique | 2009 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 19, Issue:18 | Design and synthesis of bile acid-based amino sterols as antimicrobial agents. |
| AID531236 | Antifungal activity against Candida parapsilosis after 48 hrs by CLSI method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | In vitro susceptibilities of invasive isolates of Candida species: rapid increase in rates of fluconazole susceptible-dose dependent Candida glabrata isolates. |
| AID1726238 | Cytotoxicity against human HepG2 cells assessed as reduction in cell viability by XTT assay | |||
| AID1157176 | Antifungal activity against Trichophyton mentagrophytes PMC 6552 after 72 hrs by CLSI broth microdilution method | 2014 | European journal of medicinal chemistry, Aug-18, Volume: 83 | Synthesis, biological evaluation and structure-activity correlation study of a series of imidazol-based compounds as Candida albicans inhibitors. |
| AID1238920 | Antifungal activity against Candida albicans WTBF-50 by microbroth dilution method | 2015 | Bioorganic & medicinal chemistry, Sep-01, Volume: 23, Issue:17 | Synthesis and antifungal evaluation of head-to-head and head-to-tail bisamidine compounds. |
| AID1138336 | Antimicrobial activity against fluconazole-resistant Candida albicans J28 after 24 hrs by serial dilution method | 2014 | Journal of medicinal chemistry, May-08, Volume: 57, Issue:9 | Design, synthesis, and structure-activity relationship studies of novel fused heterocycles-linked triazoles with good activity and water solubility. |
| AID1491268 | Inhibition of CYP51 in Candida albicans ATCC SC5314 assessed as eburicol content at 2 ug/ml by GS-MS analysis relative to total sterols (Rvb = 0.4%) | 2017 | European journal of medicinal chemistry, Sep-08, Volume: 137 | Design, synthesis and evaluation of aromatic heterocyclic derivatives as potent antifungal agents. |
| AID1079947 | Comments (NB not yet translated). [column 'COMMENTAIRES' in source] | |||
| AID1444344 | Antifungal activity against Trichosporon asahii 1188 after 24 hrs by broth microdilution method | 2017 | European journal of medicinal chemistry, Apr-21, Volume: 130 | Structure-activity relationship studies on 3,5-dinitrophenyl tetrazoles as antitubercular agents. |
| AID106801 | Inhibition of malate dehydrogenase (MDH) | 2003 | Journal of medicinal chemistry, Oct-09, Volume: 46, Issue:21 | Identification and prediction of promiscuous aggregating inhibitors among known drugs. |
| AID1054673 | Antimicrobial activity against Cryptococcus neoformans ATCC 90113 by Alamar blue method | 2013 | European journal of medicinal chemistry, , Volume: 70 | Structure-activity relationship (SAR) and preliminary mode of action studies of 3-substituted benzylthioquinolinium iodide as anti-opportunistic infection agents. |
| AID398059 | Antifungal activity against Saccharomyces cerevisiae DSY 415 expressing Candida albicans CDR1 after 40 to 48 hrs by serial dilution method | 2003 | Journal of natural products, Dec, Volume: 66, Issue:12 | Reversal of fluconazole resistance in multidrug efflux-resistant fungi by the Dysidea arenaria sponge sterol 9alpha,11alpha-epoxycholest-7-ene-3beta,5alpha,6alpha,19-tetrol 6-acetate. |
| AID1472624 | In vitro antifungal activity against Microsporum gypseum after 7 days by serial dilution method | 2018 | Journal of medicinal chemistry, 01-11, Volume: 61, Issue:1 | Novel Terminal Bipheny-Based Diapophytoene Desaturases (CrtN) Inhibitors as Anti-MRSA/VISR/LRSA Agents with Reduced hERG Activity. |
| AID1491267 | Inhibition of CYP51 in Candida albicans ATCC SC5314 assessed as eburicol content at 0.5 ug/ml by GS-MS analysis relative to total sterols (Rvb = 0.4%) | 2017 | European journal of medicinal chemistry, Sep-08, Volume: 137 | Design, synthesis and evaluation of aromatic heterocyclic derivatives as potent antifungal agents. |
| AID619176 | Antifungal activity against Candida albicans MY 2902/2008 by broth dilution method | 2011 | Journal of medicinal chemistry, Oct-13, Volume: 54, Issue:19 | High-throughput-screening-based identification and structure-activity relationship characterization defined (S)-2-(1-aminoisobutyl)-1-(3-chlorobenzyl)benzimidazole as a highly antimycotic agent nontoxic to cell lines. |
| AID655719 | Antifungal activity against Trichoderma viride MTCC 1107 at 80 uM/ml after 48 hrs by paper disc diffusion method | 2012 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 22, Issue:8 | Design, synthesis, synergistic antimicrobial activity and cytotoxicity of 4-aryl substituted 3,4-dihydropyrimidinones of curcumin. |
| AID1235481 | Inhibition of ergosterol biosynthesis in Candida albicans 2323 assessed as ergosterol content after 16 hrs by spectrophotometer analysis | 2015 | Bioorganic & medicinal chemistry, Aug-01, Volume: 23, Issue:15 | Imidazole clubbed 1,3,4-oxadiazole derivatives as potential antifungal agents. |
| AID553844 | Antifungal activity against Saccharomyces cerevisiae ADCDR1 expressing Candida albicans CDR1 efflux pump in YNPG-proline medium after 24 hrs by microdilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | Enhanced susceptibility to antifungal oligopeptides in yeast strains overexpressing ABC multidrug efflux pumps. |
| AID1369443 | Antifungal activity against Candida albicans cgmcc 2.2086 after 48 hrs by broth microdilution method | 2018 | Journal of medicinal chemistry, 05-10, Volume: 61, Issue:9 | Combating Drug-Resistant Fungi with Novel Imperfectly Amphipathic Palindromic Peptides. |
| AID530960 | Antifungal activity against Candida tropicalis ATCC 750 after 48 hrs by CLSI method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Potent in vitro antifungal activities of naturally occurring acetylenic acids. |
| AID623053 | Antifungal activity against Aspergillus fumigatus 231 after 48 hrs by microdilution method | 2011 | Bioorganic & medicinal chemistry letters, Oct-15, Volume: 21, Issue:20 | Synthesis and biological activity of desmethoxy analogues of coruscanone A. |
| AID1366577 | Antifungal activity against Candida parapsilosis ATCC 22019 after 24 hrs by micro broth dilution method | 2017 | Bioorganic & medicinal chemistry letters, 11-15, Volume: 27, Issue:22 | Novel potentially antifungal hybrids of 5-flucytosine and fluconazole: Design, synthesis and bioactive evaluation. |
| AID1367042 | Antifungal activity against Candida tropicalis after 24 hrs by micro broth dilution method | 2017 | Bioorganic & medicinal chemistry, 12-15, Volume: 25, Issue:24 | Discovery of novel nitroimidazole enols as Pseudomonas aeruginosa DNA cleavage agents. |
| AID398060 | Antifungal activity against Saccharomyces cerevisiae DSY 417 expressing Candida albicans CDR2 after 40 to 48 hrs by serial dilution method | 2003 | Journal of natural products, Dec, Volume: 66, Issue:12 | Reversal of fluconazole resistance in multidrug efflux-resistant fungi by the Dysidea arenaria sponge sterol 9alpha,11alpha-epoxycholest-7-ene-3beta,5alpha,6alpha,19-tetrol 6-acetate. |
| AID1413575 | Antifungal activity against Candida albicans ATCC 10231 by broth microdilution method | |||
| AID1154853 | Antifungal activity against fluconazole-sensitive Candida albicans SC5314 assessed as change in eburicol composition at 8 ug/ml after 24 hrs by GC-MS analysis relative to control | 2014 | ACS medicinal chemistry letters, May-08, Volume: 5, Issue:5 | Novel carboline derivatives as potent antifungal lead compounds: design, synthesis, and biological evaluation. |
| AID279117 | Antimicrobial activity against Candida tropicalis at 48 hrs | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Association of fluconazole area under the concentration-time curve/MIC and dose/MIC ratios with mortality in nonneutropenic patients with candidemia. |
| AID582245 | Antifungal activity against Candida glabrata isolated from HSCT recipients with acute or chronic GVHD receiving fluconazole assessed as maximum MIC by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Impact of antifungal prophylaxis on colonization and azole susceptibility of Candida species. |
| AID1820641 | Antifungal activity against Aspergillus fumigatus CGMCC 3.7795 assessed as inhibition of fungal growth by NCCLS protocol based method | 2022 | European journal of medicinal chemistry, Jan-15, Volume: 228 | Design, synthesis, and biological activity evaluation of 2-(benzo[b]thiophen-2-yl)-4-phenyl-4,5-dihydrooxazole derivatives as broad-spectrum antifungal agents. |
| AID594938 | Antimicrobial activity against Cryptococcus neoformans after 72 hrs by NCCLS method | 2011 | European journal of medicinal chemistry, May, Volume: 46, Issue:5 | Design and synthesis of antifungal benzoheterocyclic derivatives by scaffold hopping. |
| AID1254074 | Antibacterial activity against Pseudomonas aeruginosa 2004 after 24 hrs by two-fold serial dilution method | 2015 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 25, Issue:22 | Synthesis and biological evaluation of 1,3-diaryl pyrazole derivatives as potential antibacterial and anti-inflammatory agents. |
| AID287821 | Antifungal activity against Candida tropicalis 156 after 24 hrs | 2007 | Bioorganic & medicinal chemistry, Apr-15, Volume: 15, Issue:8 | Hybrid molecules of estrone: new compounds with potential antibacterial, antifungal, and antiproliferative activities. |
| AID518136 | Antimicrobial activity against Cryptococcus gattii serotype B isolate RB-18 assessed as concentration required for heteroresistance | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Heteroresistance of Cryptococcus gattii to fluconazole. |
| AID1201639 | Antimicrobial activity against Aspergillus fumigatus ATCC 1022 after 48 hrs by two-fold serial dilution method | 2015 | European journal of medicinal chemistry, May-05, Volume: 95 | Synthesis, biological evaluation and molecular docking of some substituted pyrazolines and isoxazolines as potential antimicrobial agents. |
| AID406951 | Antifungal activity against Candida albicans ATCC 10261 at 35 degC after 48 hrs by broth microdilution test | 2008 | Journal of medicinal chemistry, Jul-10, Volume: 51, Issue:13 | 1-[(3-Aryloxy-3-aryl)propyl]-1H-imidazoles, new imidazoles with potent activity against Candida albicans and dermatophytes. Synthesis, structure-activity relationship, and molecular modeling studies. |
| AID530963 | Antifungal activity against Candida glabrata ATCC 90030 after 48 hrs by CLSI methodCandida glabrata | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Potent in vitro antifungal activities of naturally occurring acetylenic acids. |
| AID535685 | Antibacterial activity against Cryptococcus neoformans after 72 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Antifungal susceptibilities among different serotypes of Cryptococcus gattii and Cryptococcus neoformans. |
| AID440317 | Anticandidal activity against Candida glabrata 70E after 24 hrs by spectrophotometry | 2009 | Journal of medicinal chemistry, Dec-10, Volume: 52, Issue:23 | Synthesis of new linear guanidines and macrocyclic amidinourea derivatives endowed with high antifungal activity against Candida spp. and Aspergillus spp. |
| AID521532 | Antifungal activity against Candida guilliermondii clinical isolates after 48 hrs by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | In vitro and in vivo antifungal activities of T-2307, a novel arylamidine. |
| AID509287 | Permeability across BBMEC cocultured with rat C6 cell BBB model after 24 hrs in presence of 1 ug/ml cyclosporin | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Effects of immunomodulatory and organism-associated molecules on the permeability of an in vitro blood-brain barrier model to amphotericin B and fluconazole. |
| AID436741 | Antifungal activity against Cryptococcus neoformans after 72 hrs by serial dilution method | 2009 | European journal of medicinal chemistry, Oct, Volume: 44, Issue:10 | New azoles with potent antifungal activity: design, synthesis and molecular docking. |
| AID530953 | Antifungal activity against Trichophyton mentagrophytes ATCC MYA-4439 by CLSI method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Potent in vitro antifungal activities of naturally occurring acetylenic acids. |
| AID567425 | Antifungal activity against Rhodotorula mucilaginosa after 7 days by Etest | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | In vitro antifungal activities of isavuconazole and comparators against rare yeast pathogens. |
| AID608757 | Antifungal activity against Trichophyton rubrum at 500 ug/ml after 72 hrs by agar diffusion method | 2011 | European journal of medicinal chemistry, Aug, Volume: 46, Issue:8 | Synthesis, characterization and antimicrobial studies of some new pyrazole incorporated imidazole derivatives. |
| AID1738709 | Antifungal activity against fluconazole-resistant Candida albicans 17 measured after 24 hrs by micro-broth dilution assay | 2020 | European journal of medicinal chemistry, Jul-15, Volume: 198 | Design, synthesis, and biological evaluation of novel miconazole analogues containing selenium as potent antifungal agents. |
| AID678715 | Inhibition of human CYP2D6 assessed as ratio of IC50 in absence of NADPH to IC50 for presence of NADPH using 4-methylaminoethyl-7-methoxycoumarin as substrate after 30 mins | 2012 | Chemical research in toxicology, Oct-15, Volume: 25, Issue:10 | Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds. |
| AID371229 | Antimicrobial activity against Candida albicans ATCC 64550 by broth microdilution method | 2008 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 18, Issue:24 | Carbon analogs of antifungal dioxane-triazole derivatives: synthesis and in vitro activities. |
| AID477335 | Antifungal activity against Candida albicans ATCC 24433 after 48 to 72 hrs by microdilution method | 2010 | European journal of medicinal chemistry, Apr, Volume: 45, Issue:4 | Synthesis and characterization of novel fatty acid analogs of cholesterol: in vitro antimicrobial activity. |
| AID257109 | Antifungal activity against Candida krusei | 2005 | Journal of medicinal chemistry, Dec-01, Volume: 48, Issue:24 | Design, synthesis, and microbiological evaluation of new Candida albicans CYP51 inhibitors. |
| AID582801 | Antifungal activity against Candida albicans isolate 490 harboring ERG3 D147G, T330A, A351V and ERG11 F72S, T229A, E266D, N440S, V488I, R523G mutant genes by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | Identification and characterization of four azole-resistant erg3 mutants of Candida albicans. |
| AID1551805 | Antifungal activity against Aspergillus brasiliensis ATCC 16404 after 24 hrs by microdilution method | 2019 | European journal of medicinal chemistry, Jul-01, Volume: 173 | Antibacterial activity study of 1,2,4-triazole derivatives. |
| AID518437 | Antimicrobial activity against Cryptococcus gattii serotype B isolate NIH190 assessed as heteroresistant isolates at 4 ug/ml | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Heteroresistance of Cryptococcus gattii to fluconazole. |
| AID1609937 | Inhibition of Candida albicans CYP51 assessed as increase in 14alpha-methyl ergosta-8,24(28)-dien-3beta,6alpha-diol level at 0.25 ug/ml incubated for 18 hrs by GC/MS analysis relative to control | |||
| AID561632 | Antimicrobial activity against Cryptococcus neoformans serotype A | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Heteroresistance to fluconazole in Cryptococcus neoformans is intrinsic and associated with virulence. |
| AID1565876 | Antifungal activity against Aspergillus fumigatus GIMCC 3.19 assessed as growth inhibition measured after 24 hrs by two-fold broth dilution method | 2019 | European journal of medicinal chemistry, Nov-15, Volume: 182 | Design, synthesis and biological evaluation of novel diazaspiro[4.5]decan-1-one derivatives as potential chitin synthase inhibitors and antifungal agents. |
| AID1598015 | Antifungal activity against Aspergillus fumigatus | 2019 | European journal of medicinal chemistry, May-15, Volume: 170 | Current advances of triazole alcohols derived from fluconazole: Design, in vitro and in silico studies. |
| AID257545 | Antifungal activity against Cryptococcus neoformans | 2005 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 15, Issue:23 | Synthesis and biological evaluation of novel (L)-alpha-amino acid methyl ester, heteroalkyl, and aryl substituted 1,4-naphthoquinone derivatives as antifungal and antibacterial agents. |
| AID750762 | Antifungal activity against Curvularia lunata MTCC 581 assessed as zone of inhibition at 20 uM after 48 hrs by disc diffusion method | 2013 | European journal of medicinal chemistry, Jun, Volume: 64 | Biological activity, design, synthesis and structure activity relationship of some novel derivatives of curcumin containing sulfonamides. |
| AID425138 | Antimicrobial activity against azole-resistant Candida albicans isolate CA10 assessed as growth at 0.25 ug/ml after 48 hrs by microdilution checkerboard technique relative to control | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | In vitro interactions between tacrolimus and azoles against Candida albicans determined by different methods. |
| AID518413 | Antimicrobial activity against Cryptococcus gattii serotype B isolate RB14 assessed as heteroresistant isolates at 2 ug/ml | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Heteroresistance of Cryptococcus gattii to fluconazole. |
| AID619080 | Antifungal activity against Candida albicans DSMZ 11949 by broth dilution method | 2011 | Journal of medicinal chemistry, Oct-13, Volume: 54, Issue:19 | High-throughput-screening-based identification and structure-activity relationship characterization defined (S)-2-(1-aminoisobutyl)-1-(3-chlorobenzyl)benzimidazole as a highly antimycotic agent nontoxic to cell lines. |
| AID1516836 | Antifungal activity against Aspergillus fumigatus | 2019 | Bioorganic & medicinal chemistry letters, 10-01, Volume: 29, Issue:19 | Recent advances in natural antifungal flavonoids and their derivatives. |
| AID1903359 | Antifungal activity against fluconazole resistant Aspergillus fumigatus GIMCC 3.19 assessed as reduction in fungal growth incubated for 24 hrs by two fold broth dilution method | 2022 | European journal of medicinal chemistry, Apr-05, Volume: 233 | Design, synthesis, and biological evaluation of novel spiro[pyrrolidine-2,3'-quinolin]-2'-one derivatives as potential chitin synthase inhibitors and antifungal agents. |
| AID625831 | Antifungal activity against Cryptococcus neoformans by broth microdilution method | 2011 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 21, Issue:21 | Micelles catalyzed chemoselective synthesis 'in water' and biological evaluation of oxygen containing hetero-1,4-naphthoquinones as potential antifungal agents. |
| AID582794 | Antifungal activity against Candida albicans isolate 488 harboring ERG3 H243N, T330A, A351V and ERG11 D225G, E266D, E391G, V488I mutant genes assessed as eburicol content in total sterol composition at 0.5 times MIC by GC-MS analysis | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | Identification and characterization of four azole-resistant erg3 mutants of Candida albicans. |
| AID626343 | Antifungal activity against Candida albicans MTCC 3017 at 1 mg/mL after 72 hrs by by agar-well diffusion method | 2011 | European journal of medicinal chemistry, Nov, Volume: 46, Issue:11 | Hantzsch reaction: synthesis and characterization of some new 1,4-dihydropyridine derivatives as potent antimicrobial and antioxidant agents. |
| AID535689 | Antibacterial activity against Cryptococcus gattii serotype B after 72 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Antifungal susceptibilities among different serotypes of Cryptococcus gattii and Cryptococcus neoformans. |
| AID588216 | FDA HLAED, serum glutamic oxaloacetic transaminase (SGOT) increase | 2004 | Current drug discovery technologies, Dec, Volume: 1, Issue:4 | Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling. |
| AID619172 | Antifungal activity against Candida glabrata AN 8626 by broth dilution method | 2011 | Journal of medicinal chemistry, Oct-13, Volume: 54, Issue:19 | High-throughput-screening-based identification and structure-activity relationship characterization defined (S)-2-(1-aminoisobutyl)-1-(3-chlorobenzyl)benzimidazole as a highly antimycotic agent nontoxic to cell lines. |
| AID563614 | Effect on sterol composition in Candida albicans isolate 14 expressing wild type erg11 and erg5 assessed as lanosterol level after 2 hrs by gas chromatography | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | A clinical isolate of Candida albicans with mutations in ERG11 (encoding sterol 14alpha-demethylase) and ERG5 (encoding C22 desaturase) is cross resistant to azoles and amphotericin B. |
| AID762386 | Antifungal activity against Saccharomyces cerevisiae NCYC 694 after 24 to 72 hrs by microdilution method | 2013 | European journal of medicinal chemistry, Aug, Volume: 66 | Synthesis, in vitro antifungal activity and in silico study of 3-(1,2,4-triazol-1-yl)flavanones. |
| AID424918 | Antimicrobial activity against azole-resistant Candida albicans isolate CA10 assessed as growth at 32 ug/ml co-treated with 0.004 ug/ml calcineurin signaling inhibitor tacrolimus after 48 hrs by microdilution checkboard technique relative to control | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | In vitro interactions between tacrolimus and azoles against Candida albicans determined by different methods. |
| AID581868 | Antifungal activity against Candida glabrata isolated from neutropenic subject 1102 with AML or MDS stool after 26 days prophylaxis by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Impact of antifungal prophylaxis on colonization and azole susceptibility of Candida species. |
| AID1205759 | Antifungal activity against Cryptococcus neoformans ATCC 24067 after 72 hrs by microdilution method | 2015 | ACS medicinal chemistry letters, Mar-12, Volume: 6, Issue:3 | Synthesis of a New Peptide-Coumarin Conjugate: A Potential Agent against Cryptococcosis. |
| AID301289 | Antifungal activity against Candida parapsilosis ATCC 22019 after 48 hrs by broth micro dilution technique | 2007 | Bioorganic & medicinal chemistry, Nov-01, Volume: 15, Issue:21 | Synthesis of disulfide esters of dialkylaminocarbothioic acid as potent, non-detergent spermicidal agents. |
| AID440770 | Antifungal activity against Botrytis fabae after 24-48 hrs by microdilution susceptibility test | 2009 | European journal of medicinal chemistry, Dec, Volume: 44, Issue:12 | Enaminonitrile in heterocyclic synthesis: synthesis and antimicrobial evaluation of some new pyrazole, isoxazole and pyrimidine derivatives incorporating a benzothiazole moiety. |
| AID1491260 | Inhibition of CYP51 in Candida albicans ATCC SC5314 assessed as obtusifoliol content at 8 ug/ml by GS-MS analysis relative to total sterols (Rvb = 0.6%) | 2017 | European journal of medicinal chemistry, Sep-08, Volume: 137 | Design, synthesis and evaluation of aromatic heterocyclic derivatives as potent antifungal agents. |
| AID1783066 | Antifungal activity against fluconazole-sensitive Candida albicans 0304103 assessed as inhibition of fungal growth | 2021 | European journal of medicinal chemistry, Oct-05, Volume: 221 | Lanosterol 14α-demethylase (CYP51)/histone deacetylase (HDAC) dual inhibitors for treatment of Candida tropicalis and Cryptococcus neoformans infections. |
| AID536636 | Antimicrobial activity against Candida albicans ATCC 10145 by twofold serial dilution method | 2010 | European journal of medicinal chemistry, Nov, Volume: 45, Issue:11 | Synthesis of new pyrrolo[2,3-d]pyrimidine derivatives as antibacterial and antifungal agents. |
| AID1199857 | Inhibition of Vps75-stimulated recombinant Saccharomyces cerevisiae histone acetyltransferase Rtt109 using [3H]-acetyl-CoA assessed as acetate incorporation after 30 mins by liquid scintillation counting in presence of 1 mM DTT | 2015 | Journal of medicinal chemistry, Mar-12, Volume: 58, Issue:5 | PAINS in the assay: chemical mechanisms of assay interference and promiscuous enzymatic inhibition observed during a sulfhydryl-scavenging HTS. |
| AID1114815 | Antifungal activity against Saccharomyces cerevisiae RSKK 251 after 18 to 24 hr by double microdilution method | 2013 | Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents, Aug, Volume: 22, Issue:8 | |
| AID537526 | Antifungal activity against Cryptococcus neoformans H99 after 72 hrs by broth microdilution method | 2010 | Bioorganic & medicinal chemistry, Nov-15, Volume: 18, Issue:22 | Synthesis of new antifungal peptides selective against Cryptococcus neoformans. |
| AID1674378 | Antifungal activity against Cryptococcus neoformans H99 by CLSI protocol-based broth serial dilution method | |||
| AID678713 | Inhibition of human CYP2C9 assessed as ratio of IC50 in absence of NADPH to IC50 for presence of NADPH using 7-methoxy-4-trifluoromethylcoumarin-3-acetic acid as substrate after 30 mins | 2012 | Chemical research in toxicology, Oct-15, Volume: 25, Issue:10 | Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds. |
| AID405068 | Antifungal activity against Candida krusei ATCC 6258 isolate from cutaneous-lymphatic sporotrichosis patient after 72 hrs by ATB Fungus 2 method | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | In vitro susceptibility of Sporothrix schenckii to six antifungal agents determined using three different methods. |
| AID526824 | Antifungal activity against Candida glabrata ATCC 48435 assessed as concentration required to 80% growth inhibition using alamar blue staining after 18 to 72 hrs by microdilution method | 2010 | Bioorganic & medicinal chemistry, Nov-01, Volume: 18, Issue:21 | 1,3-Benzoxazole-4-carbonitrile as a novel antifungal scaffold of β-1,6-glucan synthesis inhibitors. |
| AID721540 | Antifungal activity against Candida albicans after 24 hrs by broth microdilution assay | 2013 | Journal of medicinal chemistry, Jan-10, Volume: 56, Issue:1 | Sulfonylureas have antifungal activity and are potent inhibitors of Candida albicans acetohydroxyacid synthase. |
| AID758159 | Antifungal activity against Candida mycoderma after 24 hrs by twofold broth dilution method | 2013 | Bioorganic & medicinal chemistry, Jul-15, Volume: 21, Issue:14 | Synthesis and bioactive evaluation of novel hybrids of metronidazole and berberine as new type of antimicrobial agents and their transportation behavior by human serum albumin. |
| AID1295976 | Antimicrobial activity against Candida glabrata after 24 hrs by two fold serial dilution method | 2016 | Journal of natural products, Feb-26, Volume: 79, Issue:2 | Antifungal Quinoline Alkaloids from Waltheria indica. |
| AID1719179 | Antifungal activity against fluconazole-resistant Candida albicans B4 assessed as reduction in microbial growth | 2021 | Bioorganic & medicinal chemistry letters, 03-01, Volume: 35 | A new 1-nitro-9-aminoacridine derivative targeting yeast topoisomerase II able to overcome fluconazole-resistance. |
| AID1911621 | Antifungal activity against Candida albicans 28A assessed as fungal growth inhibition by broth microdilution assay | 2022 | Journal of medicinal chemistry, 06-09, Volume: 65, Issue:11 | Development of Lipo-γ-AA Peptides as Potent Antifungal Agents. |
| AID405060 | Antifungal activity against Sporothrix schenckii P30915 isolate from cutaneous-lymphatic sporotrichosis patient after 72 hrs by modified NCCLS M38-A method | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | In vitro susceptibility of Sporothrix schenckii to six antifungal agents determined using three different methods. |
| AID568481 | Antifungal activity against Aspergillus flavus KCCM 11899 after 2 days by twofold broth dilution method | 2011 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 21, Issue:3 | Synthesis and antifungal activity of furo[2,3-f]quinolin-5-ols. |
| AID293877 | Antifungal activity against Candida albicans CMAH 0503 after 48 to 72 hrs by broth microdilution method | 2007 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 17, Issue:6 | Synthesis of pseudopeptides based L-tryptophan as a potential antimicrobial agent. |
| AID532558 | Antifungal activity against Saccharomyces cerevisiae BY4741 assessed as growth rate at 8 ug/ml (Rvb = 0.144%) | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | Differential azole antifungal efficacies contrasted using a Saccharomyces cerevisiae strain humanized for sterol 14 alpha-demethylase at the homologous locus. |
| AID1157165 | Antifungal activity against Cryptococcus neoformans PMC 2115 after 72 hrs by CLSI broth microdilution method | 2014 | European journal of medicinal chemistry, Aug-18, Volume: 83 | Synthesis, biological evaluation and structure-activity correlation study of a series of imidazol-based compounds as Candida albicans inhibitors. |
| AID1357639 | Cytotoxicity against human HEK293 cells assessed as cell viability at 250 uM after 72 hrs by MTT assay relative to control | 2018 | European journal of medicinal chemistry, May-10, Volume: 151 | Synthesis, molecular modeling studies and evaluation of antifungal activity of a novel series of thiazole derivatives. |
| AID1863781 | Antifungal activity against Candida albicans SN152 harboring CAS5 mutant assessed as inhibition of fungal growth by broth microdilution method | 2022 | European journal of medicinal chemistry, Oct-05, Volume: 240 | β-Nitrostyrene derivatives as broad range potential antifungal agents targeting fungal cell wall. |
| AID510160 | Antifungal activity against Candida parapsilosis ATCC 22019 by spectrophotometry | 2010 | European journal of medicinal chemistry, Sep, Volume: 45, Issue:9 | A study of cytotoxicity of novel chlorokojic acid derivatives with their antimicrobial and antiviral activities. |
| AID279127 | Ratio of AUC in non-surviving candidemia patient to MIC at 24 hrs against Candida species | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Association of fluconazole area under the concentration-time curve/MIC and dose/MIC ratios with mortality in nonneutropenic patients with candidemia. |
| AID582218 | Antifungal activity against Candida glabrata isolated from HSCT recipients with acute or chronic GVHD prior to initiation of posaconazole therapy by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Impact of antifungal prophylaxis on colonization and azole susceptibility of Candida species. |
| AID1238922 | Antifungal activity against Candida glabrata ATCC 90030 WTBF-86 by microbroth dilution method | 2015 | Bioorganic & medicinal chemistry, Sep-01, Volume: 23, Issue:17 | Synthesis and antifungal evaluation of head-to-head and head-to-tail bisamidine compounds. |
| AID489685 | Antifungal activity against Aspergillus niger after 7 days by serial dilution method | 2010 | European journal of medicinal chemistry, Jul, Volume: 45, Issue:7 | Benzylidene/2-chlorobenzylidene hydrazides: synthesis, antimicrobial activity, QSAR studies and antiviral evaluation. |
| AID519051 | Antifungal activity against Curvularia species after 48 hrs by broth microdilution | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | Antimicrobial activity of omiganan pentahydrochloride against contemporary fungal pathogens responsible for catheter-associated infections. |
| AID1592340 | Antifungal activity against Aspergillus flavus ATCC 204304 measured after 72 hrs by agar dilution method | 2019 | European journal of medicinal chemistry, Apr-01, Volume: 167 | Efficient click chemistry towards novel 1H-1,2,3-triazole-tethered 4H-chromene-d-glucose conjugates: Design, synthesis and evaluation of in vitro antibacterial, MRSA and antifungal activities. |
| AID1352423 | Antifungal activity against Candida mycoderma ATCC 96918 by CLSI two fold serial dilution method | 2018 | European journal of medicinal chemistry, Feb-25, Volume: 146 | Discovery of 2-aminothiazolyl berberine derivatives as effectively antibacterial agents toward clinically drug-resistant Gram-negative Acinetobacter baumanii. |
| AID1689212 | Antifungal activity against fluconazole-resistant Candida auris 381 assessed as reduction in fungal growth incubated for 24 hrs by CLSI based broth microdilution method | 2020 | European journal of medicinal chemistry, Mar-01, Volume: 189 | Oxadiazolylthiazoles as novel and selective antifungal agents. |
| AID497819 | Antifungal activity against Fusarium sp. clinical isolates after 48 hrs by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | In vitro activity of thimerosal against ocular pathogenic fungi. |
| AID544873 | Antimicrobial activity against Candida dubliniensis harboring MRR1 CM1 mutant gene by microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | Gain-of-function mutations in the transcription factor MRR1 are responsible for overexpression of the MDR1 efflux pump in fluconazole-resistant Candida dubliniensis strains. |
| AID1551294 | Antibacterial activity against Escherichia coli 1924 assessed as reduction in bacterial cell growth incubated for 24 hrs by ELISA | 2019 | European journal of medicinal chemistry, Jun-15, Volume: 172 | Synthesis and biological evaluation of tryptophan-derived rhodanine derivatives as PTP1B inhibitors and anti-bacterial agents. |
| AID1113445 | Antifungal activity against Aspergillus niger assessed as growth inhibition at 50 ug/ml by cup-plate method (Rvb = 8 to 10 mm) | 2013 | Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents, , Volume: 22, Issue:4 | Synthesis and biological evaluation of 2-(5-substituted-1-((diethylamino)methyl)-2-oxoindolin-3-ylidene)- |
| AID289664 | Antimicrobial activity against Aspergillus fumigatus after 72 hrs by broth dilution assay | 2007 | Bioorganic & medicinal chemistry letters, Jan-15, Volume: 17, Issue:2 | N/C-4 substituted azetidin-2-ones: synthesis and preliminary evaluation as new class of antimicrobial agents. |
| AID1300878 | Antifungal activity against Candida albicans clinical isolate after 24 hrs by broth microdilution method | 2016 | European journal of medicinal chemistry, Jul-19, Volume: 117 | Novel 1,3-thiazolidin-4-one derivatives as promising anti-Candida agents endowed with anti-oxidant and chelating properties. |
| AID1549166 | Inhibition of CYP51 in azole-resistant Candida albicans 0304103 assessed as reduction in ERG11 gene expression at 32 ug/ml after 16 hrs by SYBR Green-1 dye based RT-PCR analysis | 2020 | Journal of medicinal chemistry, 05-28, Volume: 63, Issue:10 | Discovery of Novel Fungal Lanosterol 14α-Demethylase (CYP51)/Histone Deacetylase Dual Inhibitors to Treat Azole-Resistant Candidiasis. |
| AID444051 | Total clearance in human | 2010 | Journal of medicinal chemistry, Feb-11, Volume: 53, Issue:3 | Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. |
| AID516311 | Antimicrobial activity against Cryptococcus gattii serotype C isolate NIH403 assessed as concentration required for heteroresistance | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Heteroresistance of Cryptococcus gattii to fluconazole. |
| AID1157174 | Antifungal activity against Trichophyton mentagrophytes PMC 6509 after 72 hrs by CLSI broth microdilution method | 2014 | European journal of medicinal chemistry, Aug-18, Volume: 83 | Synthesis, biological evaluation and structure-activity correlation study of a series of imidazol-based compounds as Candida albicans inhibitors. |
| AID1738736 | Inhibition of CYP51 in azole-resistant Candida albicans ATCC SC531 assessed as Obtusifoliol level at 2 ug/ml incubated for 16 hrs by LC-MS analysis relative to control | 2020 | European journal of medicinal chemistry, Jul-15, Volume: 198 | Design, synthesis, and biological evaluation of novel miconazole analogues containing selenium as potent antifungal agents. |
| AID50308 | Compound was tested for antifungal activity against growth of three strains Candida krusei | 2000 | Bioorganic & medicinal chemistry letters, Apr-17, Volume: 10, Issue:8 | Synthesis and antifungal activity of a ferrocene-fluconazole analogue. |
| AID1550463 | Antifungal activity against Candida guilliermondii IBA 155 assessed as diameter of zone inhibition at 0.025 mg incubated for 24 hrs by disc diffusion method | 2019 | European journal of medicinal chemistry, Jun-01, Volume: 171 | Antimicrobial and KPC/AmpC inhibitory activity of functionalized benzosiloxaboroles. |
| AID369384 | Antimicrobial activity against Candida palmioleophila isolate | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | In vitro susceptibility to posaconazole of 1,903 yeast isolates recovered in France from 2003 to 2006 and tested by the method of the European committee on antimicrobial susceptibility testing. |
| AID1754363 | Antifungal activity against Candida albicans ATCC 24443 assessed as reduction in fungal growth incubated for 48 hrs by broth microdilution method based spectrophotometric analysis | 2021 | Bioorganic & medicinal chemistry, 07-01, Volume: 41 | Iodinated 1,2-diacylhydrazines, benzohydrazide-hydrazones and their analogues as dual antimicrobial and cytotoxic agents. |
| AID1380527 | Antibiofilm activity against Candida albicans ATCC 90028 grown on polystyrene surface assessed as inhibition of biofilm formation added immediately after cell adhesion by MTT assay | 2018 | Bioorganic & medicinal chemistry letters, 06-01, Volume: 28, Issue:10 | Biofilm inhibition and anti-Candida activity of a cationic lipo-benzamide molecule with twin-nonyl chain. |
| AID1497595 | Antifungal activity against fluconazole-susceptible Candida albicans isolate 93 after 24 hrs by broth microdilution method | 2018 | Bioorganic & medicinal chemistry letters, 07-15, Volume: 28, Issue:13 | Benzofuro[3,2-d]pyrimidines inspired from cercosporamide CaPkc1 inhibitor: Synthesis and evaluation of fluconazole susceptibility restoration. |
| AID597999 | Antifungal activity against Candida albicans in yeast extract-peptone-glucose medium at 300 ug/ml after 48 hrs by disc diffusion assay | 2011 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 21, Issue:11 | Synthesis and evaluation of indole-based new scaffolds for antimicrobial activities--identification of promising candidates. |
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| AID625830 | Antifungal activity against Candida albicans by broth microdilution method | 2011 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 21, Issue:21 | Micelles catalyzed chemoselective synthesis 'in water' and biological evaluation of oxygen containing hetero-1,4-naphthoquinones as potential antifungal agents. |
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| AID351032 | Antimicrobial activity against Candida krusei by broth microdilution method | 2009 | European journal of medicinal chemistry, Mar, Volume: 44, Issue:3 | 2-Acylhydrazino-5-arylpyrrole derivatives: synthesis and antifungal activity evaluation. |
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| AID1728462 | Antifungal activity against fluconazole-resistant Candida albicans 17# assessed as inhibition of microbial growth by NCCLS protocol based method | 2021 | European journal of medicinal chemistry, Jan-15, Volume: 210 | Novel naphthylamide derivatives as dual-target antifungal inhibitors: Design, synthesis and biological evaluation. |
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| AID497804 | Antifungal activity against fluconazole-resistant Candida glabrata isolate 02 by broth microdilution assay | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Assessment of the in vitro kinetic activity of caspofungin against Candida glabrata. |
| AID518672 | Antimicrobial activity against Cryptococcus gattii serotype C isolate NIH18 assessed as heteroresistant isolates at 8 ug/ml | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Heteroresistance of Cryptococcus gattii to fluconazole. |
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| AID424904 | Antimicrobial activity against azole-resistant Candida albicans isolate CA10 assessed as growth at 4 ug/ml cotreated with 0.008 ug/ml calcineurin signaling inhibitor tacrolimus after 48 hrs by microdilution checkerboard technique relative to control | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | In vitro interactions between tacrolimus and azoles against Candida albicans determined by different methods. |
| AID772327 | Antifungal activity against fluconazole-resistant Candida albicans DSY289 harboring ERG11 gene mutant and increase expressing of CDR1 and CDR2 genes after 24 hrs by visually and spectrophotometric analysis | 2013 | ACS medicinal chemistry letters, Sep-12, Volume: 4, Issue:9 | Novel Macrocyclic Amidinoureas: Potent Non-Azole Antifungals Active against Wild-Type and Resistant Candida Species. |
| AID581902 | Antifungal activity against Candida glabrata isolated from HSCT recipient 807 with acute or chronic GVHD mouth after 114 days prophylaxis by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Impact of antifungal prophylaxis on colonization and azole susceptibility of Candida species. |
| AID581866 | Antifungal activity against Candida albicans isolated from HSCT recipient 301 with acute or chronic GVHD mouth after 114 days prophylaxis by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Impact of antifungal prophylaxis on colonization and azole susceptibility of Candida species. |
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| AID511029 | Antimicrobial activity against Aspergillus flavus assessed as inhibition of mycelial growth by poisoned food method | 2010 | European journal of medicinal chemistry, Sep, Volume: 45, Issue:9 | Hypervalent iodine(III) mediated synthesis of novel unsymmetrical 2,5-disubstituted 1,3,4-oxadiazoles as antibacterial and antifungal agents. |
| AID52776 | Compound was tested for the inhibition of Chymotrypsinogen | 2003 | Journal of medicinal chemistry, Oct-09, Volume: 46, Issue:21 | Identification and prediction of promiscuous aggregating inhibitors among known drugs. |
| AID477334 | Antifungal activity Cryptococcus neoformans at 30 ug/mL after 48 to 72 hrs by disk diffusion method | 2010 | European journal of medicinal chemistry, Apr, Volume: 45, Issue:4 | Synthesis and characterization of novel fatty acid analogs of cholesterol: in vitro antimicrobial activity. |
| AID1695823 | Antifungal activity against Candida albicans ATCC 50193 incubated for 24 hrs by microdilution method | 2019 | European journal of medicinal chemistry, Apr-15, Volume: 168 | Comprehensive review on the anti-bacterial activity of 1,2,3-triazole hybrids. |
| AID555020 | Antifungal activity against Candida krusei by reference dilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | In vitro activities of fluconazole and voriconazole against clinical isolates of Candida spp. determined by disk diffusion testing in Turin, Italy. |
| AID567442 | Antifungal activity against Trichosporon domesticum after 48 hrs by Etest | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | In vitro antifungal activities of isavuconazole and comparators against rare yeast pathogens. |
| AID425142 | Antimicrobial activity against azole-resistant Candida albicans isolate CA10 assessed as growth at 4 ug/ml after 48 hrs by microdilution checkerboard technique relative to control | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | In vitro interactions between tacrolimus and azoles against Candida albicans determined by different methods. |
| AID405076 | Antifungal activity against Sporothrix schenckii isolate from cutaneous-lymphatic sporotrichosis patient after 72 hrs by Sensititre YeastOne method | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | In vitro susceptibility of Sporothrix schenckii to six antifungal agents determined using three different methods. |
| AID736604 | Antifungal activity against caspofungin-resistant Candida glabrata R assessed as growth inhibition after 24 to 48 hrs by CLSI microbroth dilution method | 2013 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 23, Issue:6 | Synthesis and anti-Candida activity of novel 2-hydrazino-1,3-thiazole derivatives. |
| AID516496 | Antimicrobial activity against Cryptococcus gattii serotype B isolate RB-11 assessed as concentration required for heteroresistance | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Heteroresistance of Cryptococcus gattii to fluconazole. |
| AID1418535 | Cytotoxicity against human HepG2 cells by MTT assay | 2018 | Bioorganic & medicinal chemistry letters, 12-01, Volume: 28, Issue:22 | Design, synthesis, and biological evaluation of 4-chloro-2H-thiochromenes featuring nitrogen-containing side chains as potent antifungal agents. |
| AID530731 | Antifungal activity against Candida albicans ATCC 14053 at 163.3 uM after 48 hrs by CLSI method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Potent in vitro antifungal activities of naturally occurring acetylenic acids. |
| AID1872498 | Antifungal activity against Candida albicans | 2022 | European journal of medicinal chemistry, Mar-05, Volume: 231 | Synthetic approaches and structural diversity of triazolylbutanols derived from voriconazole in the antifungal drug development. |
| AID1898210 | Antifungal activity against Candida albicans SC5314 infected in ICR mouse assessed as delay in mortality at 0.5 mg/kg, po qd infected with fungus for 2 hrs prior to compound addition for 7 days and measured for 20 days | |||
| AID1472822 | Antifungal activity against Candida parapsilosis ATCC 22019 after 48 hrs by broth dilution method | 2018 | Journal of medicinal chemistry, 01-11, Volume: 61, Issue:1 | Alkylated Piperazines and Piperazine-Azole Hybrids as Antifungal Agents. |
| AID554999 | Antifungal activity against Candida parapsilosis assessed as percent susceptible isolates at 25 ug/disc by CLSI M44-A disk diffusion method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | In vitro activities of fluconazole and voriconazole against clinical isolates of Candida spp. determined by disk diffusion testing in Turin, Italy. |
| AID1904367 | Antifungal activity against FLC-resistant Candida albicans 904 assessed as fungal growth inhibition by CLSI based serial microbroth dilution method | 2022 | European journal of medicinal chemistry, Apr-05, Volume: 233 | Design, synthesis, and evaluation of novel 3-thiophene derivatives as potent fungistatic and fungicidal reagents based on a conformational restriction strategy. |
| AID416852 | Antifungal activity against Trichophyton mentagrophytes DUMC160.03 infected in human skin at 2 fold MIC administered 30 mins post infection followed by once in every 2 days for 7 days by scanning electron microscopy relative to control | 2007 | Antimicrobial agents and chemotherapy, Oct, Volume: 51, Issue:10 | Targeting the calcineurin pathway enhances ergosterol biosynthesis inhibitors against Trichophyton mentagrophytes in vitro and in a human skin infection model. |
| AID1472823 | Antifungal activity against Aspergillus flavus ATCC MYA-3631 after 48 hrs by broth dilution method | 2018 | Journal of medicinal chemistry, 01-11, Volume: 61, Issue:1 | Alkylated Piperazines and Piperazine-Azole Hybrids as Antifungal Agents. |
| AID642908 | Antifungal activity against Cryptococcus neoformans ATCC 66031 | 2011 | ACS medicinal chemistry letters, May-12, Volume: 2, Issue:5 | Natural Product Based 6-Hydroxy-2,3,4,6-tetrahydropyrrolo[1,2-a]pyrimidinium Scaffold as A New Antifungal Template. |
| AID1287614 | Antifungal activity against Aspergillus niger clinical isolate after 18 to 24 hrs by micro-dilution method | 2016 | European journal of medicinal chemistry, May-04, Volume: 113 | Synthesis of newer 1,2,3-triazole linked chalcone and flavone hybrid compounds and evaluation of their antimicrobial and cytotoxic activities. |
| AID1391295 | Antifungal activity against fluconazole-resistant Cryptococcus neoformans serotype A TES9 harboring erg11 mutant measured over 4 days | 2018 | Bioorganic & medicinal chemistry, 05-15, Volume: 26, Issue:9 | Synthesis and biological evaluation of aminothiazoles against Histoplasma capsulatum and Cryptococcus neoformans. |
| AID518175 | Antimicrobial activity against Cryptococcus gattii serotype B isolate NIH198 assessed as heteroresistant isolates at 2 ug/ml | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Heteroresistance of Cryptococcus gattii to fluconazole. |
| AID1707488 | Antifungal activity against Candida krusei 10153 incubated for 48 hrs by microdilution assay | 2021 | Journal of medicinal chemistry, 01-28, Volume: 64, Issue:2 | Novel Carboline Fungal Histone Deacetylase (HDAC) Inhibitors for Combinational Treatment of Azole-Resistant Candidiasis. |
| AID1859334 | Antimicrobial activity against Candida parapsilosis ATCC 22010 | 2022 | Journal of medicinal chemistry, 02-24, Volume: 65, Issue:4 | Application of the All-Hydrocarbon Stapling Technique in the Design of Membrane-Active Peptides. |
| AID547569 | Antifungal activity against Candida guilliermondii after 24 to 72 hrs by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | In vitro antifungal activities of bis(alkylpyridinium)alkane compounds against pathogenic yeasts and molds. |
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| AID1556223 | Inhibition of CYP51 in Candida albicans ATCC SC5314 assessed as lanosterol level at 0.13 ug/ml incubated for 16 hrs by GC/MS analysis (Rvb = 0%) | 2019 | European journal of medicinal chemistry, Sep-01, Volume: 177 | Design, synthesis, and structure-activity relationship studies of l-amino alcohol derivatives as broad-spectrum antifungal agents. |
| AID118051 | In vivo evaluation of % survival rate after peroral administration on 3rd day at dose 10 mg/kg | 1995 | Journal of medicinal chemistry, Sep-29, Volume: 38, Issue:20 | Synthesis and antifungal activity of new azole derivatives containing an N-acylmorpholine ring. |
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| AID519464 | Antimicrobial activity against Cryptococcus neoformans var. grubii by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | In Vitro activity of the new azole isavuconazole (BAL4815) compared with six other antifungal agents against 162 Cryptococcus neoformans isolates from Cuba. |
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| AID655587 | Antifungal activity against Aspergillus fumigatus by microbroth dilution method | 2012 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 22, Issue:8 | New triazole derivatives as antifungal agents: synthesis via click reaction, in vitro evaluation and molecular docking studies. |
| AID609893 | Antifungal activity against Candida kefyr by micro-broth dilution method | 2011 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 21, Issue:15 | Synthesis, in vitro evaluation and molecular docking studies of new triazole derivatives as antifungal agents. |
| AID382538 | Antifungal activity against Candida albicans ATCC 10231 after 48 hrs standard broth microdilution method | 2008 | European journal of medicinal chemistry, Jan, Volume: 43, Issue:1 | Synthesis, structure and biological activity of pseudopeptidic macrolides based on an amino alcohol. |
| AID750199 | Antifungal activity against Cryptococcus laurentii after 48 hrs by CLSI M27A3 broth microdilution method | 2013 | European journal of medicinal chemistry, Jun, Volume: 64 | Synthesis, antifungal and cytotoxic activities of 2-aryl-3-((piperidin-1-yl)ethyl)thiazolidinones. |
| AID1079936 | Choleostatic liver toxicity, either proven histopathologically or where the ratio of maximal ALT or AST activity above normal to that of Alkaline Phosphatase is < 2 (see ACUTE). Value is number of references indexed. [column 'CHOLE' in source] | |||
| AID1392827 | Inhibition of Cyp51 in Candida albicans ATCC SC5314 assessed as eburicol content at 0.5 ug/ml after 16 hrs by GC-MS analysis (Rvb = 0.4%) | 2018 | Bioorganic & medicinal chemistry, 07-23, Volume: 26, Issue:12 | Design, synthesis and evaluation of benzoheterocycle analogues as potent antifungal agents targeting CYP51. |
| AID1595059 | Antifungal activity against Candida albicans TA | 2019 | European journal of medicinal chemistry, May-15, Volume: 170 | Tetrazole hybrids and their antifungal activities. |
| AID48072 | Evaluation of In vitro antifungal activity against Candida pseudotropicalis ATCC 28838 by broth macro dilution method | 1995 | Journal of medicinal chemistry, Sep-29, Volume: 38, Issue:20 | Synthesis and antifungal activity of new azole derivatives containing an N-acylmorpholine ring. |
| AID555816 | Antifungal activity against azole-resistant Candida albicans 5674 after 48 hrs | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Relative contributions of the Candida albicans ABC transporters Cdr1p and Cdr2p to clinical azole resistance. |
| AID584395 | Antifungal activity against 8 days cultured Candida krusei isolated from neutropenic subject with AML or MDS stool after 12 days of prophylaxis by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Impact of antifungal prophylaxis on colonization and azole susceptibility of Candida species. |
| AID1602369 | Antifungal activity against Aspergillus fumigatus 7544 after 48 hrs by spectrophotometery | 2019 | Journal of medicinal chemistry, 03-14, Volume: 62, Issue:5 | Discovery of Carboline Derivatives as Potent Antifungal Agents for the Treatment of Cryptococcal Meningitis. |
| AID309846 | Antifungal activity against Aspergillus niger after 7 days by twofold serial dilution method | 2007 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 17, Issue:21 | Quantitative structure-activity relationship studies for prediction of antimicrobial activity of synthesized 2,4-hexadienoic acid derivatives. |
| AID1179901 | Antimicrobial activity against Aspergillus flavus by two-fold serial dilution technique | 2014 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 24, Issue:15 | Synthesis and bioactive evaluation of a novel series of coumarinazoles. |
| AID1689857 | Antifungal activity against Candida albicans CAAL93 infected in Swiss mouse assessed as survival at 10 mg/kg, po after 14 days relative to control | 2020 | European journal of medicinal chemistry, Mar-01, Volume: 189 | New azole antifungals with a fused triazinone scaffold. |
| AID1491251 | Inhibition of CYP51 in Candida albicans ATCC SC5314 assessed as ergosterol content at 0.03125 ug/ml by GS-MS analysis relative to total sterols (Rvb = 98.7%) | 2017 | European journal of medicinal chemistry, Sep-08, Volume: 137 | Design, synthesis and evaluation of aromatic heterocyclic derivatives as potent antifungal agents. |
| AID1877285 | Antifungal activity against Candida krusei GIM2.1 assessed as fungal growth inhibition by NCCLS protocol based method | 2022 | European journal of medicinal chemistry, Jan-05, Volume: 227 | Broadening antifungal spectrum and improving metabolic stablity based on a scaffold strategy: Design, synthesis, and evaluation of novel 4-phenyl-4,5-dihydrooxazole derivatives as potent fungistatic and fungicidal reagents. |
| AID1911629 | Fungicidal activity against Candida albicans SC5314 assessed as fungal growth inhibition incubated for 24 hrs by resazurin dye based assay | 2022 | Journal of medicinal chemistry, 06-09, Volume: 65, Issue:11 | Development of Lipo-γ-AA Peptides as Potent Antifungal Agents. |
| AID371231 | Antimicrobial activity against Candida glabrata ATCC 90030 by broth microdilution method | 2008 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 18, Issue:24 | Carbon analogs of antifungal dioxane-triazole derivatives: synthesis and in vitro activities. |
| AID521536 | Antifungal activity against Cryptococcus neoformans clinical isolates after 72 hrs by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | In vitro and in vivo antifungal activities of T-2307, a novel arylamidine. |
| AID546072 | Antifungal activity against Candida glabrata isolated from candidemia patient by AFST-EUCAST microdilution method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | A 10-year survey of antifungal susceptibility of candidemia isolates from intensive care unit patients in Greece. |
| AID1495978 | Antifungal activity against Microsporum gypseum infected in guinea pig skin assessed as recovery from infection at 10 mg/g administered once daily via superficial route for 15 days measured after 30 days post last dose relative to control | 2018 | Bioorganic & medicinal chemistry, 07-23, Volume: 26, Issue:12 | Efficiency of newly prepared thiazole derivatives against some cutaneous fungi. |
| AID538383 | Antifungal activity against Cryptococcus neoformans by serial dilution method | 2010 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 20, Issue:23 | Synthesis and in vitro antifungal activities of new 3-substituted benzopyrone derivatives. |
| AID555597 | Antimicrobial activity against Ustilago spp by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Activity profile in vitro of micafungin against Spanish clinical isolates of common and emerging species of yeasts and molds. |
| AID1658341 | Antifungal activity against fluconazole-resistant Candida albicans 901 assessed as reduction in fungal growth by NCCLS method | 2020 | ACS medicinal chemistry letters, Jun-11, Volume: 11, Issue:6 | Construction and Evaluation of Molecular Models: Guide and Design of Novel SE Inhibitors. |
| AID563608 | Effect on sterol composition in Candida albicans isolate 14 expressing wild type erg11 and erg5 assessed as ergosterol level after 2 hrs by gas chromatography | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | A clinical isolate of Candida albicans with mutations in ERG11 (encoding sterol 14alpha-demethylase) and ERG5 (encoding C22 desaturase) is cross resistant to azoles and amphotericin B. |
| AID1877837 | Antifungal activity against Candida albicans CA558 by microdilution method | 2022 | Bioorganic & medicinal chemistry letters, 02-15, Volume: 58 | Synthesis and antifungal evaluation of phenol-derived bis(indolyl)methanes combined with FLC against Candida albicans. |
| AID719307 | Antimicrobial activity against Candida albicans NCIM 3471 by broth dilution method | 2012 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 22, Issue:23 | Synthesis, characterization, antidepressant and antioxidant activity of novel piperamides bearing piperidine and piperazine analogues. |
| AID1180455 | Cytotoxicity against human HepG2 cells assessed as reduction in cell viability after 24 hrs by MTS assay | 2014 | Bioorganic & medicinal chemistry, Aug-01, Volume: 22, Issue:15 | Synthesis and biological activity of new salicylanilide N,N-disubstituted carbamates and thiocarbamates. |
| AID1190608 | Antimicrobial activity against Klebsiella pneumoniae ATCC 10031 assessed as inhibition of microbial growth incubated for 24 hrs by broth dilution method | 2015 | Bioorganic & medicinal chemistry letters, Feb-15, Volume: 25, Issue:4 | Synthesis, antimicrobial activity and molecular docking of novel tetracyclic scaffolds incorporating a flavonoid framework with medium sized oxygen heterocycles. |
| AID1557083 | Antifungal activity against Candida guilliermondii T-47 assessed as reduction in fungal cell growth incubated for 24 hrs by MTT based broth double dilution method | 2019 | European journal of medicinal chemistry, Oct-01, Volume: 179 | Antifungal activity, mode of action variability, and subcellular distribution of coumarin-based antifungal azoles. |
| AID1602390 | Induction of cell cycle arrest in Cryptococcus neoformans H99 assessed as accumulation at S phase at 4 ug/ml after 24 hrs by propidium iodide-staining based FACS analysis (Rvb = 51.64%) | 2019 | Journal of medicinal chemistry, 03-14, Volume: 62, Issue:5 | Discovery of Carboline Derivatives as Potent Antifungal Agents for the Treatment of Cryptococcal Meningitis. |
| AID1707531 | Antifungal activity against Candida albicans 0304103 infected in ICR mouse model of candidiasis assessed as reduction in morphological changes of budded-to-hyphal transition at 1 mg/kg, ip dosed 24 hrs post infection and measured after 5 days by H and E s | 2021 | Journal of medicinal chemistry, 01-28, Volume: 64, Issue:2 | Novel Carboline Fungal Histone Deacetylase (HDAC) Inhibitors for Combinational Treatment of Azole-Resistant Candidiasis. |
| AID453446 | Antifungal activity against Candida albicans ATCC 2091 after 48 hrs by broth microdilution method | 2010 | Bioorganic & medicinal chemistry letters, Jan-15, Volume: 20, Issue:2 | Fluconazole analogues containing 2H-1,4-benzothiazin-3(4H)-one or 2H-1,4-benzoxazin-3(4H)-one moieties, a novel class of anti-Candida agents. |
| AID531233 | Antifungal activity against Candida tropicalis after 48 hrs by CLSI method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | In vitro susceptibilities of invasive isolates of Candida species: rapid increase in rates of fluconazole susceptible-dose dependent Candida glabrata isolates. |
| AID781088 | Antifungal activity against Candida albicans MTCC-227 after 24 to 72 hrs by broth dilution method | 2013 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 23, Issue:22 | Unusual transformation of substituted-3-formylchromones to pyrimidine analogues: synthesis and antimicrobial activities of 5-(o-hydroxyaroyl)pyrimidines. |
| AID1898197 | Inhibition of CYP51 in Candida albicans SC5314 assessed as eburicol level at 0.5 ug/ml measured after 12 hrs by GC-MS analysis (Rvb = 0.00%) | |||
| AID1898224 | Antifungal activity against Candida albicans 100 infected in ICR mouse assessed as median survival time at 0.25 mg/kg, po qd infected with fungus for 2 hrs prior to compound addition for 7 days and measured for 20 days | |||
| AID1497597 | Antifungal activity against fluconazole-resistant Candida albicans isolate 2 after 24 hrs by broth microdilution method | 2018 | Bioorganic & medicinal chemistry letters, 07-15, Volume: 28, Issue:13 | Benzofuro[3,2-d]pyrimidines inspired from cercosporamide CaPkc1 inhibitor: Synthesis and evaluation of fluconazole susceptibility restoration. |
| AID1783076 | Inhibition of biofilm formation in Cryptococcus neoformans H99 at 8 ug/ml incubated for 24 hrs by XTT reduction assay | 2021 | European journal of medicinal chemistry, Oct-05, Volume: 221 | Lanosterol 14α-demethylase (CYP51)/histone deacetylase (HDAC) dual inhibitors for treatment of Candida tropicalis and Cryptococcus neoformans infections. |
| AID1369457 | Fungicidal activity against Candida albicans SP3931 after 96 hrs | 2018 | Journal of medicinal chemistry, 05-10, Volume: 61, Issue:9 | Combating Drug-Resistant Fungi with Novel Imperfectly Amphipathic Palindromic Peptides. |
| AID323599 | Antifungal activity against Candida sp. bloodstream isolates by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5 | In vitro activities of isavuconazole and other antifungal agents against Candida bloodstream isolates. |
| AID397209 | Antifungal activity against Candida albicans ATCC 90028 assessed as inhibition of fungal ergosterol synthesis at 1.56 ug/mL after 16 hrs by UV spectrophotometry | 2009 | European journal of medicinal chemistry, May, Volume: 44, Issue:5 | Antifungal unsaturated cyclic Mannich ketones and amino alcohols: study of mechanism of action. |
| AID47892 | In vitro evaluation of minimum inhibitory concentration against Candida parapsilosis 61 | 1995 | Journal of medicinal chemistry, Sep-29, Volume: 38, Issue:20 | Synthesis and antifungal activity of new azole derivatives containing an N-acylmorpholine ring. |
| AID581905 | Antifungal activity against Candida glabrata isolated from HSCT recipient 491 with acute or chronic GVHD mouth receiving antifungal drug after 112 days prophylaxis by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Impact of antifungal prophylaxis on colonization and azole susceptibility of Candida species. |
| AID1357637 | Antifungal activity against Paracoccidioides brasiliensis Pb18 after 7 days by microbroth dilution assay | 2018 | European journal of medicinal chemistry, May-10, Volume: 151 | Synthesis, molecular modeling studies and evaluation of antifungal activity of a novel series of thiazole derivatives. |
| AID1886044 | Synergistic antifungal activity against Cryptococcus neoformans clinical isolate HN19 assessed as fractional inhibitory concentration index incubated for 72 hrs in presence of P163-0892 by broth microdilution method | |||
| AID39835 | Minimum inhibitory concentration of compound for antifungal activity against Aspergillus fumigatus | 2000 | Bioorganic & medicinal chemistry letters, Oct-02, Volume: 10, Issue:19 | Novel antifungals based on 4-substituted imidazole: a combinatorial chemistry approach to lead discovery and optimization. |
| AID1493829 | Antifungal activity against Candida glabrata 537 after 24 hrs by spectrophotometric analysis | 2018 | European journal of medicinal chemistry, Jan-01, Volume: 143 | Discovery of simplified sampangine derivatives as novel fungal biofilm inhibitors. |
| AID50318 | In vitro antifungal activity against Candida neoformans CY 1057 | 2000 | Bioorganic & medicinal chemistry letters, Jul-03, Volume: 10, Issue:13 | Synthesis and structure-activity relationships of novel fungal chitin synthase inhibitors. |
| AID420664 | Antifungal activity against Trichophyton rubrum by micro-broth dilution method | 2009 | European journal of medicinal chemistry, May, Volume: 44, Issue:5 | Design, synthesis, and biological evaluation of novel triazole derivatives as inhibitors of cytochrome P450 14alpha-demethylase. |
| AID642928 | Antifungal activity against Trichophyton mentagrophytes ATCC MYA-4439 | 2011 | ACS medicinal chemistry letters, May-12, Volume: 2, Issue:5 | Natural Product Based 6-Hydroxy-2,3,4,6-tetrahydropyrrolo[1,2-a]pyrimidinium Scaffold as A New Antifungal Template. |
| AID1825529 | Anti-Cryptococcal activity against Cryptococcus neoformans infected pneumonia and encephalitis C57BL/6J mouse model assessed as reduction in brain edema at 8 mg/kg, iv administered once a day for 9 days and measured at 24 hrs at last post-dosage | 2022 | Journal of medicinal chemistry, 02-10, Volume: 65, Issue:3 | Synthesis of Hemiprotonic Phenanthroline-Phenanthroline |
| AID1898184 | Inhibition of 24 hrs mature biofilms in Candida albicans SC5314 at 0.25 to 64 ug/ml | |||
| AID772324 | Antifungal activity against fluconazole-resistant Candida albicans DSY735 expressing high level of CDR1 and CDR2 genes after 24 hrs by visually and spectrophotometric analysis | 2013 | ACS medicinal chemistry letters, Sep-12, Volume: 4, Issue:9 | Novel Macrocyclic Amidinoureas: Potent Non-Azole Antifungals Active against Wild-Type and Resistant Candida Species. |
| AID1359820 | Antifungal activity against Candida albicans ATCC 76615 measured after 48 hrs by two-dimensional broth microdilution checkboard method | |||
| AID1898193 | Inhibition of CYP51 in Candida albicans SC5314 assessed as ergosterol level at 4 ug/ml measured after 12 hrs by GC-MS analysis (Rvb = 72.58%) | |||
| AID470654 | Antifungal activity against Candida albicans after 24 hrs by agar dilution method | 2009 | Journal of natural products, Sep, Volume: 72, Issue:9 | Cerebrosides of the halotolerant fungus Alternaria raphani isolated from a sea salt field. |
| AID522126 | Antimicrobial activity against deltacrz1 mutant containing Candida glabrata TG173 complemented with CRZ1 gene by colorimetric microdilution method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Roles of calcineurin and Crz1 in antifungal susceptibility and virulence of Candida glabrata. |
| AID1602373 | Antifungal activity against Cryptococcus gattii ATCC 14116 after 72 hrs by spectrophotometery | 2019 | Journal of medicinal chemistry, 03-14, Volume: 62, Issue:5 | Discovery of Carboline Derivatives as Potent Antifungal Agents for the Treatment of Cryptococcal Meningitis. |
| AID554708 | Antimicrobial activity against Candida krusei NZCDC 89.102 after 48 hrs by liquid microdilution assay | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Abc1p is a multidrug efflux transporter that tips the balance in favor of innate azole resistance in Candida krusei. |
| AID518147 | Antimicrobial activity against Cryptococcus gattii serotype B isolate B4506 assessed as concentration required for heteroresistance | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Heteroresistance of Cryptococcus gattii to fluconazole. |
| AID613566 | Antifungal activity against Candida albicans ATCC 76615 after 24 hrs by twofold serial dilution method | 2011 | European journal of medicinal chemistry, Sep, Volume: 46, Issue:9 | Synthesis of novel fluconazoliums and their evaluation for antibacterial and antifungal activities. |
| AID1898170 | Antifungal activity against Candida tropicalis ATCC750 | |||
| AID340952 | Antifungal activity against Candida albicans isolates by NCCLS M27-A2 method | 2007 | Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8 | Cross-resistance to medical and agricultural azole drugs in yeasts from the oropharynx of human immunodeficiency virus patients and from environmental Bavarian vine grapes. |
| AID531188 | Antifungal activity against Trichophyton rubrum ATCC MYA-4438 at 163.3 uM after 5 days by CLSI method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Potent in vitro antifungal activities of naturally occurring acetylenic acids. |
| AID1689859 | Antifungal activity against Candida albicans DSY292 harboring Erg1l G464S/R467K/Y132 mutant infected in Swiss mouse assessed as survival at 15 mg/kg, po after 5 days | 2020 | European journal of medicinal chemistry, Mar-01, Volume: 189 | New azole antifungals with a fused triazinone scaffold. |
| AID202697 | In vitro antifungal activity against Saccharomyces cerevisiae Y9 | 2004 | Bioorganic & medicinal chemistry letters, Jan-05, Volume: 14, Issue:1 | Novel galbonolide derivatives as IPC synthase inhibitors: design, synthesis and in vitro antifungal activities. |
| AID625689 | Antifungal activity against Aspergillus niger at 30 ug/ml after 48 hrs by agar disk diffusion assay | 2011 | European journal of medicinal chemistry, Nov, Volume: 46, Issue:11 | L-Proline anchored multicomponent synthesis of novel pyrido[2,3-a]carbazoles; investigation of in vitro antimicrobial, antioxidant, cytotoxicity and structure activity relationship studies. |
| AID49808 | Fungicidal versus fungistatic activity of bifunctional sphingolipids against Candida glabrata at a concentration of 10 ug/mL before dilution replating; no growth in media | 2002 | Bioorganic & medicinal chemistry letters, Aug-19, Volume: 12, Issue:16 | Antifungal activity of bifunctional sphingolipids. Intramolecular synergism within long-chain alpha,omega-bis-aminoalcohols. |
| AID1198414 | Fungicidal activity against Candida tropicalis ATCC 750 incubated at 37 degC for 48 hrs by broth dilution method | 2015 | European journal of medicinal chemistry, Mar-26, Volume: 93 | Synthesis, QSAR and anticandidal evaluation of 1,2,3-triazoles derived from naturally bioactive scaffolds. |
| AID425161 | Antifungal activity against Candida glabrata isolate 4198 after 48 hrs by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | Posaconazole activity against Candida glabrata after exposure to caspofungin or amphotericin B. |
| AID244910 | In vitro concentration required against Candida albicans strain YEM 15 | 2004 | Bioorganic & medicinal chemistry letters, Oct-18, Volume: 14, Issue:20 | Quinazolinone fungal efflux pump inhibitors. Part 2: In vitro structure-activity relationships of (N-methyl-piperazinyl)-containing derivatives. |
| AID424650 | Antimicrobial activity against azole-resistant Candida albicans isolate CA10 assessed as growth at 0.25 ug/ml cotreated with 0.063 ug/ml calcineurin signaling inhibitor Tacrolimus after 48 hrs by microdilution checkboard technique relative to control | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | In vitro interactions between tacrolimus and azoles against Candida albicans determined by different methods. |
| AID1885970 | Antifungal activity against Cryptococcus neoformans clinical isolate HN19 assessed as fungal growth inhibition incubated for 72 hrs by broth microdilution method | |||
| AID369382 | Antimicrobial activity against Candida lipolytica isolate | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | In vitro susceptibility to posaconazole of 1,903 yeast isolates recovered in France from 2003 to 2006 and tested by the method of the European committee on antimicrobial susceptibility testing. |
| AID765554 | Antimicrobial activity against Candida albicans ATCC 60193 after 18 to 24 hrs by double microdilution method | 2013 | European journal of medicinal chemistry, Sep, Volume: 67 | Microwave assisted synthesis of some hybrid molecules derived from norfloxacin and investigation of their biological activities. |
| AID584592 | Antifungal activity against -2 days cultured Candida glabrata isolated from HSCT recipient with acute or chronic GVHD mouth receiving antifungal therapy for 172 days after 114 days of prophylaxis by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Impact of antifungal prophylaxis on colonization and azole susceptibility of Candida species. |
| AID510617 | Antifungal activity against Candida parapsilosis by serial dilution method | 2010 | European journal of medicinal chemistry, Sep, Volume: 45, Issue:9 | Design, synthesis and antifungal activity of isosteric analogues of benzoheterocyclic N-myristoyltransferase inhibitors. |
| AID1419477 | Antimicrobial activity against Staphylococcus aureus by two fold serial dilution method | 2017 | European journal of medicinal chemistry, May-05, Volume: 131 | Synthesis and biological evaluation of a new series of benzimidazole derivatives as antimicrobial, antiquorum-sensing and antitumor agents. |
| AID1487493 | Antifungal activity against Aspergillus niger assessed as zone of inhibition at 25 ug/ml measured after 24 hrs by well diffusion method | 2017 | Bioorganic & medicinal chemistry letters, 08-15, Volume: 27, Issue:16 | Synthesis, antioxidant, antifungal, molecular docking and ADMET studies of some thiazolyl hydrazones. |
| AID526732 | Antifungal activity against Candida albicans KCCM 50235 after 1 day | 2010 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 20, Issue:22 | Synthesis and antifungal activity of benzofuran-5-ols. |
| AID1076849 | Inhibition of biofilm formation of Candida albicans ATCC 10231 by XTT reduction assay | 2014 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 24, Issue:6 | Activity of caffeic acid derivatives against Candida albicans biofilm. |
| AID1246671 | Antifungal activity against Cryptococcus neoformans ATCC 28957 assessed as reduction in cell viability at 26 uM after 6 to 72 hrs by MTT assay | 2015 | European journal of medicinal chemistry, Sep-18, Volume: 102 | Thiazole compounds with activity against Cryptococcus gattii and Cryptococcus neoformans in vitro. |
| AID582776 | Antifungal activity against Candida albicans isolate 490 harboring ERG3 D147G, T330A, A351V and ERG11 F72S, T229A, E266D, N440S, V488I, R523G mutant genes assessed as 14alpha-methyl fecosterol content in total sterol composition at 0.5 times MIC by GC-MS | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | Identification and characterization of four azole-resistant erg3 mutants of Candida albicans. |
| AID385147 | Antifungal activity against Candida albicans ATCC 10231 at 100 ug/ml after 48 hrs by agar diffusion assay | 2008 | Journal of natural products, Apr, Volume: 71, Issue:4 | Antifungal metabolites from the plant endophytic fungus Pestalotiopsis foedan. |
| AID405020 | Antifungal activity against Sporothrix schenckii P20825 isolate from cutaneous-lymphatic sporotrichosis patient after 72 hrs by ATB Fungus 2 method | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | In vitro susceptibility of Sporothrix schenckii to six antifungal agents determined using three different methods. |
| AID719315 | Antimicrobial activity against Bacillus subtilis NCIM 2999 by broth dilution method | 2012 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 22, Issue:23 | Synthesis, characterization, antidepressant and antioxidant activity of novel piperamides bearing piperidine and piperazine analogues. |
| AID477742 | Antimicrobial activity against Candida albicans after 24 hrs | 2010 | European journal of medicinal chemistry, Apr, Volume: 45, Issue:4 | An eco-friendly synthesis and antimicrobial activities of dihydro-2H-benzo- and naphtho-1,3-oxazine derivatives. |
| AID322753 | Inhibition of human CYP51 expressed in Topp 3 cells by lanosterol demethylase assay | 2007 | Drug metabolism and disposition: the biological fate of chemicals, Mar, Volume: 35, Issue:3 | Three-dimensional quantitative structure-activity relationship analysis of human CYP51 inhibitors. |
| AID657564 | Antifungal activity against fluconazole-sensitive Candida albicans SC5314 assessed as growth inhibition at 8 ug/ml after 24 hrs by alamar blue fluorescence assay | 2012 | Bioorganic & medicinal chemistry letters, May-01, Volume: 22, Issue:9 | Overcoming fluconazole resistance in Candida albicans clinical isolates with tetracyclic indoles. |
| AID1190609 | Antimicrobial activity against Candida albicans ATCC 10231 assessed as inhibition of microbial growth incubated for 72 hrs by broth dilution method | 2015 | Bioorganic & medicinal chemistry letters, Feb-15, Volume: 25, Issue:4 | Synthesis, antimicrobial activity and molecular docking of novel tetracyclic scaffolds incorporating a flavonoid framework with medium sized oxygen heterocycles. |
| AID1309044 | Antibacterial activity against methicillin-resistant Staphylococcus aureus isolate SDSM1503 after 24 hrs by broth microdilution method | 2016 | Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15 | Synthesis of riccardin D derivatives as potent antimicrobial agents. |
| AID1689834 | Inhibition of sterol biosynthesis in Candida albicans CAAL93 assessed as ergostadienol level at 10 ng/ml after 18 hrs by GC-MS analysis (Rvb = 1.6%) | 2020 | European journal of medicinal chemistry, Mar-01, Volume: 189 | New azole antifungals with a fused triazinone scaffold. |
| AID550086 | Antifungal activity against Candida albicans after 48 hrs by broth microdilution assay | 2011 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 21, Issue:1 | Design and synthesis of 3-(azol-1-yl)phenylpropanes as microbicidal spermicides for prophylactic contraception. |
| AID771478 | Antimicrobial activity against Candida albicans MTCC 183 after 12 hrs by well diffusion method | 2013 | European journal of medicinal chemistry, Oct, Volume: 68 | Design and regioselective synthesis of trifluoromethylquinolone derivatives as potent antimicrobial agents. |
| AID1157183 | Antifungal activity against Candida glabrata PMC 0851R after 48 hrs by CLSI broth microdilution method | 2014 | European journal of medicinal chemistry, Aug-18, Volume: 83 | Synthesis, biological evaluation and structure-activity correlation study of a series of imidazol-based compounds as Candida albicans inhibitors. |
| AID245567 | In vitro concentration required to inhibit 80% growth of Saccharomyces cerevisiae strain Y170 (CgCDR1 over-expressed) after 48 h | 2004 | Bioorganic & medicinal chemistry letters, Oct-18, Volume: 14, Issue:20 | Quinazolinone fungal efflux pump inhibitors. Part 2: In vitro structure-activity relationships of (N-methyl-piperazinyl)-containing derivatives. |
| AID373518 | Antifungal activity against Candida albicans ATCC 10231 by macro-broth dilution method | 2009 | European journal of medicinal chemistry, May, Volume: 44, Issue:5 | Synthesis and antiparasitic and antifungal evaluation of 2'-arylsubstituted-1H,1'H-[2,5']bisbenzimidazolyl-5-carboxamidines. |
| AID535914 | Antifungal activity against Aspergillus niger ATCC 6275 after 24 hrs by broth microdilution method | 2010 | European journal of medicinal chemistry, Nov, Volume: 45, Issue:11 | Synthesis and pharmacological evaluation of clubbed isopropylthiazole derived triazolothiadiazoles, triazolothiadiazines and mannich bases as potential antimicrobial and antitubercular agents. |
| AID521510 | Antifungal activity against Aspergillus fumigatus IFM 46895 after 48 hrs by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | In vitro and in vivo antifungal activities of T-2307, a novel arylamidine. |
| AID619645 | Antifungal activity against Cryptococcus neoformans H-99 after 72 hrs by broth microdilution method | 2011 | Bioorganic & medicinal chemistry, Oct-01, Volume: 19, Issue:19 | Antifungal activity of a series of 1,2-benzisothiazol-3(2H)-one derivatives. |
| AID1369459 | Fungicidal activity against Candida albicans SP3902 after 96 hrs | 2018 | Journal of medicinal chemistry, 05-10, Volume: 61, Issue:9 | Combating Drug-Resistant Fungi with Novel Imperfectly Amphipathic Palindromic Peptides. |
| AID369383 | Antimicrobial activity against Candida pelliculosa isolate | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | In vitro susceptibility to posaconazole of 1,903 yeast isolates recovered in France from 2003 to 2006 and tested by the method of the European committee on antimicrobial susceptibility testing. |
| AID1199859 | Inhibition of yeast histone acetyltransferase Gcn5-Ada2-Ada3 complex using tetramer and [3H]-acetyl-CoA assessed as acetate incorporation after 30 mins by liquid scintillation counting in presence of 1 mM DTT | 2015 | Journal of medicinal chemistry, Mar-12, Volume: 58, Issue:5 | PAINS in the assay: chemical mechanisms of assay interference and promiscuous enzymatic inhibition observed during a sulfhydryl-scavenging HTS. |
| AID772335 | Antifungal activity against wild type Candida guilliermondii after 24 hrs by visually and spectrophotometric analysis | 2013 | ACS medicinal chemistry letters, Sep-12, Volume: 4, Issue:9 | Novel Macrocyclic Amidinoureas: Potent Non-Azole Antifungals Active against Wild-Type and Resistant Candida Species. |
| AID47582 | Evaluation of In vitro antifungal activity against Candida albicans 406 by broth macro dilution method | 1995 | Journal of medicinal chemistry, Sep-29, Volume: 38, Issue:20 | Synthesis and antifungal activity of new azole derivatives containing an N-acylmorpholine ring. |
| AID566725 | Antifungal activity against Candida krusei after 24 hrs by MTT assay | 2011 | European journal of medicinal chemistry, Jan, Volume: 46, Issue:1 | Synthesis and biological evaluation of novel 2,4-disubstituted-1,3-thiazoles as anti-Candida spp. agents. |
| AID1405036 | Antifungal activity against Candida albicans after 24 hrs by two-fold broth microdilution assay | 2018 | European journal of medicinal chemistry, Jul-15, Volume: 155 | Novel carbazole-triazole conjugates as DNA-targeting membrane active potentiators against clinical isolated fungi. |
| AID1495980 | Antifungal activity against Candida albicans | 2018 | Bioorganic & medicinal chemistry, 07-23, Volume: 26, Issue:12 | Efficiency of newly prepared thiazole derivatives against some cutaneous fungi. |
| AID518444 | Antimicrobial activity against Cryptococcus gattii serotype B isolate B5763 assessed as heteroresistant isolates at 4 ug/ml | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Heteroresistance of Cryptococcus gattii to fluconazole. |
| AID1524622 | Antibacterial activity against Staphylococcus aureus RN4220 after 24 hrs by microtiter ELISA | 2019 | Bioorganic & medicinal chemistry letters, 05-01, Volume: 29, Issue:9 | Synthesis of novel dihydrotriazine derivatives bearing 1,3-diaryl pyrazole moieties as potential antibacterial agents. |
| AID244787 | Antifungal activity to inhibit Candida parapsilosis ATCC 22019 | 2004 | Journal of medicinal chemistry, Jul-29, Volume: 47, Issue:16 | Imidazole analogues of fluoxetine, a novel class of anti-Candida agents. |
| AID518454 | Antimicrobial activity against Cryptococcus gattii serotype C isolate NIH257 assessed as heteroresistant isolates at 4 ug/ml | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Heteroresistance of Cryptococcus gattii to fluconazole. |
| AID1610308 | Antifungal activity against fluconazole-resistant Candida albicans CaR incubated for 24 hrs by CLSI protocol based microbroth dilution method | 2019 | Bioorganic & medicinal chemistry letters, 12-01, Volume: 29, Issue:23 | Design, synthesis and biological evaluation of novel semicarbazone-selenochroman-4-ones hybrids as potent antifungal agents. |
| AID429396 | Antifungal activity against Aspergillus niger MTCC 281 after 24 to 72 hrs by broth dilution method | 2009 | European journal of medicinal chemistry, Aug, Volume: 44, Issue:8 | Mechanism of unusual formation of 3-(5-phenyl-3H-[1,2,4]dithiazol-3-yl)chromen-4-ones and 4-oxo-4H-chromene-3-carbothioic acid N-phenylamides and their antimicrobial evaluation. |
| AID521982 | Antibacterial activity against Fluconazole resistant Candida albicans DSY3083 containing tac1delta/delta genotype containing CIp10 to restore URA3 function infected in BALB/c mouse administered intraperitoneally 1 hr post bacterial challenge measured 3 da | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Genetic dissection of azole resistance mechanisms in Candida albicans and their validation in a mouse model of disseminated infection. |
| AID1549170 | Inhibition of HDAC in azole-resistant Candida albicans 0304103 assessed as decrease in rhodamine 6G efflux at 32 ug/ml after 16 hrs by fluorimetry | 2020 | Journal of medicinal chemistry, 05-28, Volume: 63, Issue:10 | Discovery of Novel Fungal Lanosterol 14α-Demethylase (CYP51)/Histone Deacetylase Dual Inhibitors to Treat Azole-Resistant Candidiasis. |
| AID519282 | Antifungal activity against Candida krusei ATCC 6258 by CLSI M27-A2 microdilution method | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | Reliability of the WIDERYST susceptibility testing system for detection of in vitro antifungal resistance in yeasts. |
| AID394715 | Antifungal activity against Cryptococcus neoformans H99 expressing PCTR4-2/FAS1 assessed as logarithmic reduction in viable cells at 8 ug/ml in presence of bathocuproinedisulfonic acid | 2007 | Antimicrobial agents and chemotherapy, Oct, Volume: 51, Issue:10 | Fatty acid synthesis is essential for survival of Cryptococcus neoformans and a potential fungicidal target. |
| AID562989 | Antifungal activity against Candida albicans isolate 03-2718 infected BALB/c mouse vaginitis model assessed as reduction in fungal load in vagina at 20 mg/kg, administered through oral gavage once daily for 5 days measured on day 6 post inoculation | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | Efficacy of albaconazole against Candida albicans in a vaginitis model. |
| AID1738706 | Antifungal activity against Candida parapsilosis ATCC 22019 measured after 24 hrs by micro-broth dilution assay | 2020 | European journal of medicinal chemistry, Jul-15, Volume: 198 | Design, synthesis, and biological evaluation of novel miconazole analogues containing selenium as potent antifungal agents. |
| AID1557073 | Antifungal activity against Candida albicans SN152 assessed as zone inhibition at 25 ug incubated for 24 hrs by disk diffusion method | 2019 | European journal of medicinal chemistry, Oct-01, Volume: 179 | Antifungal activity, mode of action variability, and subcellular distribution of coumarin-based antifungal azoles. |
| AID424625 | Antimicrobial activity against azole-resistant Candida albicans isolate CA16 after 48 hrs by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | In vitro interactions between tacrolimus and azoles against Candida albicans determined by different methods. |
| AID462225 | Antifungal activity against pharmacoresistant Candida albicans AIDS68 infected in Wistar rat estrogen-dependent fungal vaginitis model assessed as fungal burden at 10 ug administered intravaginally 24 hrs after fungal infection measured on day 2 after inf | 2010 | Journal of medicinal chemistry, Mar-25, Volume: 53, Issue:6 | Identification of inhibitors of drug-resistant Candida albicans strains from a library of bicyclic peptidomimetic compounds. |
| AID529544 | Antifungal activity against Candida glabrata 06-3168 obtained from patient on compound therapy by M27-A2 method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Reduced Candida glabrata susceptibility secondary to an FKS1 mutation developed during candidemia treatment. |
| AID530950 | Antifungal activity against Trichophyton mentagrophytes ATCC 9533 by CLSI method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Potent in vitro antifungal activities of naturally occurring acetylenic acids. |
| AID531205 | Antifungal activity against Candida albicans ATCC 14053 after 48 hrs by CLSI method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Potent in vitro antifungal activities of naturally occurring acetylenic acids. |
| AID1877855 | Antifungal activity against Candida albicans at 2 ug/mL by Time-kill curve assay | 2022 | Bioorganic & medicinal chemistry letters, 02-15, Volume: 58 | Synthesis and antifungal evaluation of phenol-derived bis(indolyl)methanes combined with FLC against Candida albicans. |
| AID47581 | Evaluation of In vitro antifungal activity against Candida albicans 31 by broth macro dilution method | 1995 | Journal of medicinal chemistry, Sep-29, Volume: 38, Issue:20 | Synthesis and antifungal activity of new azole derivatives containing an N-acylmorpholine ring. |
| AID405055 | Antifungal activity against Sporothrix schenckii PJRC002 isolate from cutaneous-lymphatic sporotrichosis patient after 72 hrs by Sensititre YeastOne method | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | In vitro susceptibility of Sporothrix schenckii to six antifungal agents determined using three different methods. |
| AID519465 | Antimicrobial activity against Cryptococcus neoformans var. grubii clinical isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | In Vitro activity of the new azole isavuconazole (BAL4815) compared with six other antifungal agents against 162 Cryptococcus neoformans isolates from Cuba. |
| AID43009 | Inhibition of Candida tropicalis 156 growth for 48 hours in vitro. | 2001 | Journal of medicinal chemistry, Aug-16, Volume: 44, Issue:17 | 3-Phenyl-5-acyloxymethyl-2H,5H-furan-2-ones: synthesis and biological activity of a novel group of potential antifungal drugs. |
| AID569369 | Antifungal activity against Penicillium species at 500 ug after 24 hrs by paper disc technique | 2011 | European journal of medicinal chemistry, Feb, Volume: 46, Issue:2 | Efficient and novel one-pot synthesis of antifungal active 1-substituted-8-aryl-3-alkyl/aryl-4H-pyrazolo[4,5-f][1,2,4]triazolo[4,3-b][1,2,4]triazepines using solid support. |
| AID747351 | Antibacterial activity against Shigella dysenteriae by NCCLS method | 2013 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 23, Issue:11 | Synthesis and biological evaluation of a class of quinolone triazoles as potential antimicrobial agents and their interactions with calf thymus DNA. |
| AID1506724 | Antibacterial activity against Escherichia coli MTCC 1652 by agar dilution method | 2017 | MedChemComm, Mar-01, Volume: 8, Issue:3 | Design, synthesis, molecular-docking and antimycobacterial evaluation of some novel 1,2,3-triazolyl xanthenones. |
| AID518450 | Antimicrobial activity against Cryptococcus gattii serotype B isolate RAM002 assessed as heteroresistant isolates at 4 ug/ml | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Heteroresistance of Cryptococcus gattii to fluconazole. |
| AID42874 | Inhibition of Candida krusei ATCC 6258 growth for 24 hours in vitro. | 2001 | Journal of medicinal chemistry, Aug-16, Volume: 44, Issue:17 | 3-Phenyl-5-acyloxymethyl-2H,5H-furan-2-ones: synthesis and biological activity of a novel group of potential antifungal drugs. |
| AID1444342 | Antifungal activity against Candida glabrata 20/I after 24 hrs by broth microdilution method | 2017 | European journal of medicinal chemistry, Apr-21, Volume: 130 | Structure-activity relationship studies on 3,5-dinitrophenyl tetrazoles as antitubercular agents. |
| AID1904371 | Antifungal activity against FLC-resistant Candida albicans 311 assessed as fungal growth inhibition by CLSI based serial microbroth dilution method | 2022 | European journal of medicinal chemistry, Apr-05, Volume: 233 | Design, synthesis, and evaluation of novel 3-thiophene derivatives as potent fungistatic and fungicidal reagents based on a conformational restriction strategy. |
| AID478782 | Antifungal activity against Candida albicans ATCC 14053 after 18 hrs by broth microdilution assay | 2010 | European journal of medicinal chemistry, May, Volume: 45, Issue:5 | Synthesis, spectroscopic and biological studies on the new symmetric Schiff base derived from 2,6-diformyl-4-methylphenol with N-aminopyrimidine. |
| AID527132 | Antifungal activity against Microsporum gypseum LMGO 533 after 5 days microdilution technique | 2010 | Journal of natural products, Oct-22, Volume: 73, Issue:10 | Search for antifungal compounds from the wood of durable tropical trees. |
| AID1651342 | Antifungal activity against Cryptococcus neoformans 32605 by NCCLS protocol based broth microdilution assay | 2020 | Bioorganic & medicinal chemistry letters, 02-15, Volume: 30, Issue:4 | Design, synthesis, and structure-activity relationship studies of novel triazole agents with strong antifungal activity against Aspergillus fumigatus. |
| AID1780180 | Antifungal activity against Cryptococcus neoformans H99S assessed as inhibition of fungal growth measured after 72 hrs by Plate reader assay | |||
| AID582804 | Antifungal activity against Candida albicans isolate 14 by broth microdilution method in presence of 10 uM drug efflux inhibitor FK506 | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | Identification and characterization of four azole-resistant erg3 mutants of Candida albicans. |
| AID424893 | Antimicrobial activity against azole-resistant Candida albicans isolate CA10 assessed as growth at 4 ug/ml cotreated with 0.016 ug/ml calcineurin signaling inhibitor Tacrolimus after 48 hrs by microdilution checkboard technique relative to control | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | In vitro interactions between tacrolimus and azoles against Candida albicans determined by different methods. |
| AID1419530 | Effect on sterol composition in Candida albicans ATCC 64124 assessed as 14-alpha-methyl-ergosta-8,24(28)dien-3beta,6alpha-diol level at 0.125 ug/mL incubated for 10 mins by LC-MS analysis | 2017 | European journal of medicinal chemistry, Jun-16, Volume: 133 | Novel alkylated azoles as potent antifungals. |
| AID525596 | Antibacterial activity against Fluconazole resistant Candida albicans DSY3608 containing tac1delta/delta ERG11-1/ERG11-1 (TAC1-1) genotype by EUCAST standards based broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Genetic dissection of azole resistance mechanisms in Candida albicans and their validation in a mouse model of disseminated infection. |
| AID407010 | Antimicrobial activity against fluconazole-resistant Candida albicans FH5 dissociated biofilms at cell density of 10'3 cells/ml after 48 hrs by XTT assay | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | Role for cell density in antifungal drug resistance in Candida albicans biofilms. |
| AID388086 | Antibacterial activity at Escherichia coli | 2008 | Bioorganic & medicinal chemistry letters, Oct-15, Volume: 18, Issue:20 | Synthesis of chimeric tetrapeptide-linked cholic acid derivatives: impending synergistic agents. |
| AID1516900 | Antifungal activity against Trichophyton rubrum ATCC MYA3108 by CLSI-based microdilution method | 2019 | Bioorganic & medicinal chemistry letters, 10-01, Volume: 29, Issue:19 | Recent advances in natural antifungal flavonoids and their derivatives. |
| AID1598017 | Antifungal activity against Candida tropicalis after 24 hrs by microbroth dilution method | 2019 | European journal of medicinal chemistry, May-15, Volume: 170 | Current advances of triazole alcohols derived from fluconazole: Design, in vitro and in silico studies. |
| AID725878 | Antifungal activity against acquired-resistant Candida parapsilosis CAPA2 after 24 hrs by spectrofluorometric analysis | 2013 | ACS medicinal chemistry letters, Feb-14, Volume: 4, Issue:2 | Discovery of a novel broad-spectrum antifungal agent derived from albaconazole. |
| AID518697 | Antimicrobial activity against Cryptococcus gattii serotype B isolate VPB572-058 assessed as heteroresistant isolates at 16 ug/ml | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Heteroresistance of Cryptococcus gattii to fluconazole. |
| AID1232309 | Unbound fraction in human plasma | 2015 | Journal of medicinal chemistry, Aug-13, Volume: 58, Issue:15 | Volume of Distribution in Drug Design. |
| AID1494153 | Antifungal activity against Microsporum gypseum after 5 to 7 days | 2018 | European journal of medicinal chemistry, Jan-01, Volume: 143 | Molecular docking, design, synthesis and antifungal activity study of novel triazole derivatives. |
| AID174689 | In vivo evaluation of antifungal activity against vaginal candidosis in rat at dose 0.25 mg/kg on 15th day | 1995 | Journal of medicinal chemistry, Sep-29, Volume: 38, Issue:20 | Synthesis and antifungal activity of new azole derivatives containing an N-acylmorpholine ring. |
| AID453450 | Antifungal activity against Candida tropicalis ATCC 750 after 48 hrs by broth microdilution method | 2010 | Bioorganic & medicinal chemistry letters, Jan-15, Volume: 20, Issue:2 | Fluconazole analogues containing 2H-1,4-benzothiazin-3(4H)-one or 2H-1,4-benzoxazin-3(4H)-one moieties, a novel class of anti-Candida agents. |
| AID564275 | Antifungal activity against Candida albicans isolate 177 after 48 hrs by broth microdilution method in presence of 10 uM of efflux pump inhibitor FK506 | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | A clinical isolate of Candida albicans with mutations in ERG11 (encoding sterol 14alpha-demethylase) and ERG5 (encoding C22 desaturase) is cross resistant to azoles and amphotericin B. |
| AID369379 | Antimicrobial activity against Candida fermentati isolate | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | In vitro susceptibility to posaconazole of 1,903 yeast isolates recovered in France from 2003 to 2006 and tested by the method of the European committee on antimicrobial susceptibility testing. |
| AID448701 | Antimicrobial activity against Aspergillus niger ATCC 6275 after 24 hrs by broth microdilution method | 2009 | European journal of medicinal chemistry, Nov, Volume: 44, Issue:11 | Synthesis of new 4-isopropylthiazole hydrazide analogs and some derived clubbed triazole, oxadiazole ring systems--a novel class of potential antibacterial, antifungal and antitubercular agents. |
| AID678717 | Inhibition of human CYP3A4 assessed as ratio of IC50 in absence of NADPH to IC50 for presence of NADPH using 7-benzyloxyquinoline as substrate after 30 mins | 2012 | Chemical research in toxicology, Oct-15, Volume: 25, Issue:10 | Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds. |
| AID392373 | Antifungal activity against Aspergillus fumigatus 231 after 48 hrs by broth microdilution method | 2009 | Bioorganic & medicinal chemistry letters, Jan-15, Volume: 19, Issue:2 | Salicylanilide esters of N-protected amino acids as novel antimicrobial agents. |
| AID1168349 | Ratio of binding constant for human serum albumin in presence of Ni2+ to binding constant for human serum albumin in absence of metal ions | 2014 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 24, Issue:21 | Study the interactions between human serum albumin and two antifungal drugs: fluconazole and its analogue DTP. |
| AID1465973 | Antifungal activity against Candida albicans NR-29446 after 44 hrs by broth dilution assay | 2017 | Bioorganic & medicinal chemistry, 06-01, Volume: 25, Issue:11 | Investigation of aryl isonitrile compounds with potent, broad-spectrum antifungal activity. |
| AID440309 | Anticandidal activity against Candida albicans 4T after 24 hrs by spectrophotometry | 2009 | Journal of medicinal chemistry, Dec-10, Volume: 52, Issue:23 | Synthesis of new linear guanidines and macrocyclic amidinourea derivatives endowed with high antifungal activity against Candida spp. and Aspergillus spp. |
| AID582808 | Antifungal activity against Candida albicans isolate 490 harboring ERG3 D147G, T330A, A351V and ERG11 F72S, T229A, E266D, N440S, V488I, R523G mutant genes by broth microdilution method in presence of 10 uM drug efflux inhibitor FK506 | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | Identification and characterization of four azole-resistant erg3 mutants of Candida albicans. |
| AID1221962 | Efflux ratio of permeability from apical to basolateral side over basolateral to apical side of human Caco2 cells at 10 uM up to 120 mins by HPLC-MC analysis in presence of 1 uM of P-gp inhibitor LY335979 | 2011 | Drug metabolism and disposition: the biological fate of chemicals, Feb, Volume: 39, Issue:2 | Attenuation of intestinal absorption by major efflux transporters: quantitative tools and strategies using a Caco-2 model. |
| AID1918366 | Antifungal activity against Candida albicans infected in mouse assessed as reduction in fungal endogenous infection symptoms at 20 mg/kg, ip administered on days 2,4,6,8,10,12 and measured on day 14 by GMS staining based analysis | 2022 | Journal of medicinal chemistry, 11-10, Volume: 65, Issue:21 | Novel Aryl Alkamidazole Derivatives as Multifunctional Antifungal Inhibitors: Design, Synthesis, and Biological Evaluation. |
| AID1254317 | Antifungal activity against Candida tropicalis 156 after 48 hrs by microdilution broth method | 2015 | Bioorganic & medicinal chemistry, Nov-15, Volume: 23, Issue:22 | Novel derivatives of nitro-substituted salicylic acids: Synthesis, antimicrobial activity and cytotoxicity. |
| AID279097 | Ratio of weight normalized daily dose in candidemia patient to MIC against Candida glabrata | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Association of fluconazole area under the concentration-time curve/MIC and dose/MIC ratios with mortality in nonneutropenic patients with candidemia. |
| AID560142 | Antifungal activity against Candida glabrata isolate 22853 at 15 ug after 48 hrs by disk diffusion method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Hypersusceptibility to azole antifungals in a clinical isolate of Candida glabrata with reduced aerobic growth. |
| AID582770 | Antifungal activity against Candida albicans isolate 490 harboring ERG3 D147G, T330A, A351V and ERG11 F72S, T229A, E266D, N440S, V488I, R523G mutant genes assessed as ergosterol content in total sterol composition at 0.5 times MIC by GC-MS analysis | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | Identification and characterization of four azole-resistant erg3 mutants of Candida albicans. |
| AID1246597 | Antifungal activity against Cryptococcus neoformans WP after 48 to 72 hrs by broth microdilution method | 2015 | European journal of medicinal chemistry, Sep-18, Volume: 102 | Thiazole compounds with activity against Cryptococcus gattii and Cryptococcus neoformans in vitro. |
| AID293414 | Antifungal activity against Penicillium marneffei by serial plate dilution method | 2007 | European journal of medicinal chemistry, May, Volume: 42, Issue:5 | Synthesis of some new bioactive 3-amino-2-mercapto-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-4(3H)-one derivatives. |
| AID741614 | Antifungal activity against Candida albicans Berkout KCCM 50235 after 1 day by two fold broth dilution method | 2013 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 23, Issue:7 | Synthesis and antifungal evaluation of 7-arylamino-5,8-dioxo-5,8-dihydroisoquinoline-4-carboxylates. |
| AID1886040 | Synergistic antifungal activity against Cryptococcus neoformans clinical isolate HN2 assessed as fractional inhibitory concentration index incubated for 72 hrs in presence of P163-0892 by broth microdilution method | |||
| AID372241 | Fungistatic activity against Candida albicans SSK21 after 24 to 48 hrs by broth microdilution assay | 2007 | Antimicrobial agents and chemotherapy, Oct, Volume: 51, Issue:10 | The Ssk1p response regulator and Chk1p histidine kinase mutants of Candida albicans are hypersensitive to fluconazole and voriconazole. |
| AID584404 | Antifungal activity against 3 days cultured Candida glabrata isolated from neutropenic subject with AML or MDS stool receiving antifungal therapy for 25 days after 3 days of prophylaxis by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Impact of antifungal prophylaxis on colonization and azole susceptibility of Candida species. |
| AID293890 | Antifungal activity against fluconazole-resistant Candida albicans CMAM 0597 after 48 to 72 hrs by broth microdilution method | 2007 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 17, Issue:6 | Synthesis of pseudopeptides based L-tryptophan as a potential antimicrobial agent. |
| AID1198420 | Anticandidal activity against Candida albicans ATCC 90028 incubated at 37 degC for 24 hrs in presence of 8-((1-Benzyl-1H-1,2,3-triazol-4-yl)methoxy)quinoline by broth micro dilution method | 2015 | European journal of medicinal chemistry, Mar-26, Volume: 93 | Synthesis, QSAR and anticandidal evaluation of 1,2,3-triazoles derived from naturally bioactive scaffolds. |
| AID1651348 | Antifungal activity against fluconazole-resistant Candida albicans isolate 100 by NCCLS protocol based broth microdilution method | 2020 | Bioorganic & medicinal chemistry letters, 02-15, Volume: 30, Issue:4 | Design, synthesis, and structure-activity relationship studies of novel triazole agents with strong antifungal activity against Aspergillus fumigatus. |
| AID294562 | Antimicrobial activity against Escherichia coli ATCC 10536 at 20 ug by disk diffusion method | 2007 | European journal of medicinal chemistry, Jun, Volume: 42, Issue:6 | Rapid synthesis of sulfone derivatives as potential anti-infectious agents. |
| AID510310 | Antimicrobial activity against flucytosine, azole, and caspofungin resistant Candida glabrata bloodstream isolate 4 harboring FKS2 T1988C mutation and overexpressing CDR1 and CDR2 genes serially obtained from hematopoietic stem cell transplant recipient b | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Acquisition of flucytosine, azole, and caspofungin resistance in Candida glabrata bloodstream isolates serially obtained from a hematopoietic stem cell transplant recipient. |
| AID609975 | Antifungal activity against Rhizopus sp. at 500 ug after 24 hrs by paper disc technique relative to control | 2011 | Bioorganic & medicinal chemistry letters, Aug-15, Volume: 21, Issue:16 | Efficient synthesis of antifungal active 9-substituted-3-aryl-5H,13aH-quinolino[3,2-f][1,2,4]triazolo[4,3-b][1,2,4]triazepines in ionic liquids. |
| AID747358 | Antifungal activity against Candida utilis by NCCLS method | 2013 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 23, Issue:11 | Synthesis and biological evaluation of a class of quinolone triazoles as potential antimicrobial agents and their interactions with calf thymus DNA. |
| AID440764 | Antifungal activity against Botrytis fabae assessed as zone of inhibition diameter at 1 mg/mL after 48 hrs by twofold serial dilution method | 2009 | European journal of medicinal chemistry, Dec, Volume: 44, Issue:12 | Enaminonitrile in heterocyclic synthesis: synthesis and antimicrobial evaluation of some new pyrazole, isoxazole and pyrimidine derivatives incorporating a benzothiazole moiety. |
| AID45511 | Inhibitory effect on Candida albicans YEM12 Strain | 2004 | Journal of medicinal chemistry, Jan-01, Volume: 47, Issue:1 | Folate-synthesizing enzyme system as target for development of inhibitors and inhibitor combinations against Candida albicans-synthesis and biological activity of new 2,4-diaminopyrimidines and 4'-substituted 4-aminodiphenyl sulfones. |
| AID582790 | Antifungal activity against Candida albicans isolate 1008 harboring ERG3 K97E, L193P, V237A, A351V, A353T and ERG11 E266D mutant genes assessed as lanosterol/obtusifoliol content in total sterol composition at 0.5 times MIC by GC-MS analysis | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | Identification and characterization of four azole-resistant erg3 mutants of Candida albicans. |
| AID1886102 | Cytotoxicity against human HUVEC cells assessed as inhibition on cell growth incubated for 24 hrs by CCK-8 assay | |||
| AID392371 | Antifungal activity against Candida glabrata 20/I after 48 hrs by broth microdilution method | 2009 | Bioorganic & medicinal chemistry letters, Jan-15, Volume: 19, Issue:2 | Salicylanilide esters of N-protected amino acids as novel antimicrobial agents. |
| AID598305 | Antimicrobial activity against Candida krusei ATCC 6258 after 48 hrs by microdilution broth method | 2011 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 21, Issue:11 | Synthesis and in vitro antimicrobial activities of new (cyano-NNO-azoxy)pyrazole derivatives. |
| AID424883 | Antimicrobial activity against azole-resistant Candida albicans isolate CA10 assessed as growth at 8 ug/ml cotreated with 0.031 ug/ml calcineurin signaling inhibitor tacrolimus after 48 hrs by microdilution checkerboard technique relative to control | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | In vitro interactions between tacrolimus and azoles against Candida albicans determined by different methods. |
| AID274098 | Effect of compound on Candida albicans sensitivity to Fluconazole: Minimum inhibitory concentration required to inhibit the growth of 90% of isolates after 24h. | 2007 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 17, Issue:5 | Discovery of uracil-based histone deacetylase inhibitors able to reduce acquired antifungal resistance and trailing growth in Candida albicans. |
| AID518419 | Antimicrobial activity against Cryptococcus gattii serotype C isolate NIH257 assessed as heteroresistant isolates at 2 ug/ml | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Heteroresistance of Cryptococcus gattii to fluconazole. |
| AID415948 | Antimicrobial activity against Candida krusei by micro-broth dilution method | 2009 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 19, Issue:6 | Design, synthesis, and biological evaluation of novel 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-substituted benzylamino-2-propanols. |
| AID467290 | Antifungal activity against Microsporum gypseum by serial dilution method after 24 hrs | 2009 | Bioorganic & medicinal chemistry letters, Oct-15, Volume: 19, Issue:20 | Discovery of highly potent novel antifungal azoles by structure-based rational design. |
| AID1759425 | Fungicidal activity against Cryptococcus neoformans PFCC 93-589 by broth microdilution assay | 2021 | Bioorganic & medicinal chemistry letters, 06-01, Volume: 41 | Inhibitory effects and mechanism of antifungal action of the natural cyclic depsipeptide, aureobasidin A against Cryptococcus neoformans. |
| AID1242640 | Antibacterial activity against Pseudomonas aeruginosa ATCC BAA-427 after 16 hrs by microtiter broth dilution method | 2015 | ACS medicinal chemistry letters, Jul-09, Volume: 6, Issue:7 | Novel Chalcone-Thiazole Hybrids as Potent Inhibitors of Drug Resistant Staphylococcus aureus. |
| AID750765 | Antifungal activity against Curvularia lunata MTCC 581 assessed as zone of inhibition at 80 uM after 48 hrs by disc diffusion method | 2013 | European journal of medicinal chemistry, Jun, Volume: 64 | Biological activity, design, synthesis and structure activity relationship of some novel derivatives of curcumin containing sulfonamides. |
| AID420077 | Antifungal activity against Cryptococcus neoformans 6995 after 48 hrs by broth microdilution assay | 2009 | Bioorganic & medicinal chemistry, Jun-01, Volume: 17, Issue:11 | Bulky 1,4-benzoxazine derivatives with antifungal activity. |
| AID1598046 | Antifungal activity against Aspergillus fumigatus after 24 hrs | 2019 | European journal of medicinal chemistry, May-15, Volume: 170 | Current advances of triazole alcohols derived from fluconazole: Design, in vitro and in silico studies. |
| AID1898179 | Antifungal activity against Candida auris D12 | |||
| AID372424 | Antifungal activity against Candida albicans CBS 5983 at 32 uM after 16 hrs by BacTiter-Glow assay | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Galanin message-associated peptide suppresses growth and the budded-to-hyphal-form transition of Candida albicans. |
| AID352118 | Antifungal activity against Candida albicans after 26 hrs by serial plate dilution method | 2009 | European journal of medicinal chemistry, Mar, Volume: 44, Issue:3 | Antimicrobial studies of some novel quinazolinones fused with [1,2,4]-triazole, [1,2,4]-triazine and [1,2,4,5]-tetrazine rings. |
| AID304974 | Antifungal activity against Sporothrix schenckii by broth micro-dilution technique | 2007 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 17, Issue:1 | New antifungal flavonoid glycoside from Vitex negundo. |
| AID1872507 | In vivo antifungal activity against Candida albicans infected in CDF1 mouse treated po or iv 2 hrs after infection twice daily for 2 days measured on day 10 | 2022 | European journal of medicinal chemistry, Mar-05, Volume: 231 | Synthetic approaches and structural diversity of triazolylbutanols derived from voriconazole in the antifungal drug development. |
| AID737318 | Antimicrobial activity against Aspergillus flavus MTCC 1973 at 750 ug/ml after 72 hrs by cup plate method | 2013 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 23, Issue:7 | Synthesis of novel 2-amino-4-(5'-substituted 2'-phenyl-1H-indol-3'-yl)-6-aryl-4H-pyran-3-carbonitrile derivatives as antimicrobial and antioxidant agents. |
| AID1428242 | Antibacterial activity against Escherichia coli measured after 18 hrs by agar dilution method | 2017 | European journal of medicinal chemistry, Jan-27, Volume: 126 | An insight on synthetic and medicinal aspects of pyrazolo[1,5-a]pyrimidine scaffold. |
| AID584602 | Antifungal activity against 19 days cultured Candida krusei isolated from invasive fungal infected subject blood receiving antifungal therapy for 19 days after 6 days of prophylaxis by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Impact of antifungal prophylaxis on colonization and azole susceptibility of Candida species. |
| AID279102 | Mortality rate in Candida glabrata infected candidemia patient | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Association of fluconazole area under the concentration-time curve/MIC and dose/MIC ratios with mortality in nonneutropenic patients with candidemia. |
| AID1898156 | Antifungal activity against Candida glabrata 537 | |||
| AID519470 | Antimicrobial activity against Cryptococcus albidosimilis by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | In Vitro activity of the new azole isavuconazole (BAL4815) compared with six other antifungal agents against 162 Cryptococcus neoformans isolates from Cuba. |
| AID638557 | Antifungal activity against Candida tropicalis Berkout KCCM 50662 after 1 day by twofold broth dilution method | 2012 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 22, Issue:1 | Synthesis and antifungal activity of 6,7-bis(arylthio)-quinazoline-5,8-diones and furo[2,3-f]quinazolin-5-ols. |
| AID549020 | Antimicrobial activity against Candida krusei LMR 39-14 infected in immunosuppressed CF-1 mouse assessed as decrease in kidney bacterial burden at 40 mg/kg, ip administered once daily for 5 days measured after 10 days (Rvb= 5.22) | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Activity of anidulafungin in a murine model of Candida krusei infection: evaluation of mortality and disease burden by quantitative tissue cultures and measurement of serum (1,3)-beta-D-glucan levels. |
| AID448158 | Antimicrobial activity against Pseudomonas aeruginosa ATCC 27853 at 5 ug after 18 hrs by well diffusion method | 2009 | European journal of medicinal chemistry, Nov, Volume: 44, Issue:11 | Synthesis of some new 1,2,4-triazoles starting from isonicotinic acid hydrazide and evaluation of their antimicrobial activities. |
| AID599922 | Antifungal activity against Aspergillus niger after 96 hrs | 2011 | European journal of medicinal chemistry, Jun, Volume: 46, Issue:6 | Amberlite-IRA-402 (OH) ion exchange resin mediated synthesis of indolizines, pyrrolo [1,2-a] quinolines and isoquinolines: antibacterial and antifungal evaluation of the products. |
| AID670401 | Antifungal activity against Candida albicans MTCC 227 by well diffusion method | 2012 | Bioorganic & medicinal chemistry letters, Jul-15, Volume: 22, Issue:14 | Synthesis, biological evaluation of 5-carbomethoxymethyl-7-hydroxy-2-pentylchromone, 5-carboethoxymethyl-4',7-dihydroxyflavone and their analogues. |
| AID1728466 | Antifungal activity against fluconazole-resistant Candida albicans 904 assessed as inhibition of microbial growth by NCCLS protocol based method | 2021 | European journal of medicinal chemistry, Jan-15, Volume: 210 | Novel naphthylamide derivatives as dual-target antifungal inhibitors: Design, synthesis and biological evaluation. |
| AID1888276 | Antifungal activity against Candida albicans ATCC SC5314 assessed as change in unknown sterol level at 4 ug/ml incubated for 48 hrs by LC-MS analysis (Rvb = 4.3%) | |||
| AID521501 | Antifungal activity against Candida tropicalis IFO 1400 after 48 hrs by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | In vitro and in vivo antifungal activities of T-2307, a novel arylamidine. |
| AID537669 | Antifungal activity against Candida albicans ATCC 60193 after 18 hrs by agar-well diffusion method | 2010 | European journal of medicinal chemistry, Nov, Volume: 45, Issue:11 | Cyclization of some carbothioamide derivatives containing antipyrine and triazole moieties and investigation of their antimicrobial activities. |
| AID518698 | Antimicrobial activity against Cryptococcus gattii serotype C isolate NIH18 assessed as heteroresistant isolates at 16 ug/ml | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Heteroresistance of Cryptococcus gattii to fluconazole. |
| AID569366 | Antifungal activity against Aspergillus flavus at 1000 ug after 24 hrs by paper disc technique | 2011 | European journal of medicinal chemistry, Feb, Volume: 46, Issue:2 | Efficient and novel one-pot synthesis of antifungal active 1-substituted-8-aryl-3-alkyl/aryl-4H-pyrazolo[4,5-f][1,2,4]triazolo[4,3-b][1,2,4]triazepines using solid support. |
| AID776429 | Antifungal activity against Aspergillus flavus ATCC 11495 at 50 ug/ml after 48 hrs by disc-diffusion method | 2013 | European journal of medicinal chemistry, Nov, Volume: 69 | Synthesis, antimicrobial, antioxidant activities of novel 6-aryl-5-cyano thiouracil derivatives. |
| AID1392811 | Antifungal activity against Aspergillus fumigatus cgmcc 3.7795 after 7 days by serial dilution method | 2018 | Bioorganic & medicinal chemistry, 07-23, Volume: 26, Issue:12 | Design, synthesis and evaluation of benzoheterocycle analogues as potent antifungal agents targeting CYP51. |
| AID1491259 | Inhibition of CYP51 in Candida albicans ATCC SC5314 assessed as obtusifoliol content at 2 ug/ml by GS-MS analysis relative to total sterols (Rvb = 0.6%) | 2017 | European journal of medicinal chemistry, Sep-08, Volume: 137 | Design, synthesis and evaluation of aromatic heterocyclic derivatives as potent antifungal agents. |
| AID1155870 | Antifungal activity against Candida glabrata assessed as growth inhibition after 24 hrs by serial dilution method | 2014 | European journal of medicinal chemistry, Jul-23, Volume: 82 | Design, synthesis and antifungal activity of novel triazole derivatives containing substituted 1,2,3-triazole-piperdine side chains. |
| AID490329 | Antimicrobial activity against Bacillus subtilis ATCC 6633 after 24 hrs by microdilution assay | 2010 | European journal of medicinal chemistry, Jul, Volume: 45, Issue:7 | Synthesis and biological evaluation of some thio containing pyrrolo [2,3-d]pyrimidine derivatives for their anti-inflammatory and anti-microbial activities. |
| AID516265 | Antimicrobial activity against Cryptococcus gattii serotype B isolate NIH184 assessed as concentration required for heteroresistance | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Heteroresistance of Cryptococcus gattii to fluconazole. |
| AID1474171 | Antifungal activity against Aspergillus fumigatus cgmcc 3.7795 by broth microdilution assay | 2016 | European journal of medicinal chemistry, Nov-10, Volume: 123 | Design, synthesis, and structure-activity relationship studies of benzothiazole derivatives as antifungal agents. |
| AID613715 | Antifungal activity against Candida krusei ATCC 6258 by broth dilution method | 2011 | Bioorganic & medicinal chemistry letters, Aug-15, Volume: 21, Issue:16 | Novel hybrids of fluconazole and furanones: design, synthesis and antifungal activity. |
| AID1126572 | Antimicrobial activity against Candida albicans MTCC 227 at 500 ug/ml after 24 hrs by cup plate method | 2014 | European journal of medicinal chemistry, May-06, Volume: 78 | Synthesis and biological evaluation of N-dehydrodipeptidyl-N,N'-dicyclohexylurea analogs. |
| AID1600167 | Antifungal activity against Candida albicans NCIM 3100 assessed as zone of inhibition at 80 ug/well incubated for 48 to 72 hrs by by agar well diffusion method | 2019 | European journal of medicinal chemistry, Oct-01, Volume: 179 | Synthesis of new thiazolyl-pyrazolyl-1,2,3-triazole derivatives as potential antimicrobial agents. |
| AID1138349 | Antimicrobial activity against Candida albicans SC5314 infected in ICR mouse assessed as mean survival days at 0.5 mg/kg, po qd for 5 days starting 2 hrs post infection (Rvb = 5.2 +/- 2.35 days starting 2 hrs post infection) | 2014 | Journal of medicinal chemistry, May-08, Volume: 57, Issue:9 | Design, synthesis, and structure-activity relationship studies of novel fused heterocycles-linked triazoles with good activity and water solubility. |
| AID395836 | Antimicrobial activity against Cryptococcus neoformans after 72 hrs by standard microbroth dilution assay | 2009 | European journal of medicinal chemistry, Jan, Volume: 44, Issue:1 | Tetrahydronaphthyl azole oxime ethers: the conformationally rigid analogues of oxiconazole as antibacterials. |
| AID405103 | Antimicrobial activity against Rhizopus sp. assessed as percent of susceptible isolates after 24 hrs | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | In vitro susceptibilities of 217 clinical isolates of zygomycetes to conventional and new antifungal agents. |
| AID521520 | Antifungal activity against Mucor racemosus NBRC5403 after 24 hrs by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | In vitro and in vivo antifungal activities of T-2307, a novel arylamidine. |
| AID395325 | Lipophilicity, log P by microemulsion electrokinetic chromatography | 2009 | Journal of medicinal chemistry, Mar-26, Volume: 52, Issue:6 | Relationship between brain tissue partitioning and microemulsion retention factors of CNS drugs. |
| AID1369465 | Fungicidal activity against fluconazole-resistant Candida albicans 17546 after 96 hrs | 2018 | Journal of medicinal chemistry, 05-10, Volume: 61, Issue:9 | Combating Drug-Resistant Fungi with Novel Imperfectly Amphipathic Palindromic Peptides. |
| AID1674380 | Antifungal activity against Candida albicans SC5314 by CLSI protocol-based broth serial dilution method | |||
| AID555818 | Antifungal activity against cdr1/cdr1 deficient Candida albicans STY19 after 48 hrs | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Relative contributions of the Candida albicans ABC transporters Cdr1p and Cdr2p to clinical azole resistance. |
| AID1246585 | Antifungal activity against Cryptococcus gattii LMM818 after 48 to 72 hrs by broth microdilution method | 2015 | European journal of medicinal chemistry, Sep-18, Volume: 102 | Thiazole compounds with activity against Cryptococcus gattii and Cryptococcus neoformans in vitro. |
| AID1201640 | Antimicrobial activity against Aspergillus versicolor ATCC 10072 after 48 hrs by two-fold serial dilution method | 2015 | European journal of medicinal chemistry, May-05, Volume: 95 | Synthesis, biological evaluation and molecular docking of some substituted pyrazolines and isoxazolines as potential antimicrobial agents. |
| AID1820642 | Antifungal activity against fluconazole resistant Candida albicans CaR assessed as inhibition of fungal growth by NCCLS protocol based method | 2022 | European journal of medicinal chemistry, Jan-15, Volume: 228 | Design, synthesis, and biological activity evaluation of 2-(benzo[b]thiophen-2-yl)-4-phenyl-4,5-dihydrooxazole derivatives as broad-spectrum antifungal agents. |
| AID477332 | Antifungal activity against Candida krusei ATCC 6528 at 30 ug/mL after 48 to 72 hrs by disk diffusion method | 2010 | European journal of medicinal chemistry, Apr, Volume: 45, Issue:4 | Synthesis and characterization of novel fatty acid analogs of cholesterol: in vitro antimicrobial activity. |
| AID1303304 | Antimicrobial activity against Aspergillus flavus ATCC 204304 after 24 hrs by microbroth dilution method | 2016 | Bioorganic & medicinal chemistry letters, 06-01, Volume: 26, Issue:11 | Design, synthesis and biological evaluation of 5-fluorouracil-derived benzimidazoles as novel type of potential antimicrobial agents. |
| AID1758033 | Inhibition of CYP51 in Candida albicans ATCC SC5314 assessed as Obtusifoliol level at 0.5 ug/ml after 16 hrs by GC-MS analysis (Rvb = 0%) | 2021 | European journal of medicinal chemistry, Apr-15, Volume: 216 | Lead optimization generates selenium-containing miconazole CYP51 inhibitors with improved pharmacological profile for the treatment of fungal infections. |
| AID516259 | Antimicrobial activity against Cryptococcus gattii serotype B isolate NIH435 assessed as concentration required for heteroresistance | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Heteroresistance of Cryptococcus gattii to fluconazole. |
| AID530743 | Antifungal activity against Candida albicans ATCC 90028 at 163.3 uM after 48 hrs by CLSI method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Potent in vitro antifungal activities of naturally occurring acetylenic acids. |
| AID751632 | Antifungal activity against Candida albicans at 1000 ppm | 2013 | European journal of medicinal chemistry, Feb, Volume: 60 | Synthesis and antifungal activity of some s-mercaptotriazolobenzothiazolyl amino acid derivatives. |
| AID1494145 | Antifungal activity against Candida albicans SC5314 after 24 hrs | 2018 | European journal of medicinal chemistry, Jan-01, Volume: 143 | Molecular docking, design, synthesis and antifungal activity study of novel triazole derivatives. |
| AID1595076 | Antifungal activity against Aspergillus niger | 2019 | European journal of medicinal chemistry, May-15, Volume: 170 | Tetrazole hybrids and their antifungal activities. |
| AID1456577 | Antifungal activity against Candida albicans isolate SC5314 by micro-broth dilution method | 2017 | Bioorganic & medicinal chemistry letters, 05-15, Volume: 27, Issue:10 | Design, synthesis, and in vitro evaluation of novel antifungal triazoles. |
| AID1728469 | Antifungal activity against Candida albicans ATCC SC5314 assessed as induction of cell fracture at 10 nM/mL by polarizing microscopy | 2021 | European journal of medicinal chemistry, Jan-15, Volume: 210 | Novel naphthylamide derivatives as dual-target antifungal inhibitors: Design, synthesis and biological evaluation. |
| AID1271233 | Antifungal activity against Candida albicans ATCC 24433 after 24 to 36 hrs by broth microdilution method | 2015 | ACS medicinal chemistry letters, Nov-12, Volume: 6, Issue:11 | Silicon Incorporated Morpholine Antifungals: Design, Synthesis, and Biological Evaluation. |
| AID1510728 | Antifungal activity against Candida albicans | 2019 | European journal of medicinal chemistry, Oct-01, Volume: 179 | Nitroimidazole-containing compounds and their antibacterial and antitubercular activities. |
| AID490937 | Antifungal activity against Trichoderma viride TT after 72 hrs by disc diffusion method | 2010 | European journal of medicinal chemistry, Jul, Volume: 45, Issue:7 | Synthesis and biological evaluation of a novel series of 2,2-bisaminomethylated aurone analogues as anti-inflammatory and antimicrobial agents. |
| AID554951 | Inhibition of Candida krusei Abc1g expressed in Saccharomyces cerevisiae isolate ADdelta assessed as fractional inhibitory concentration index at 2.5 ug/ml after 48 hrs by checkerboard susceptibility assay | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Abc1p is a multidrug efflux transporter that tips the balance in favor of innate azole resistance in Candida krusei. |
| AID1246680 | Antifungal activity against Cryptococcus neoformans 27JF assessed as reduction in cell viability at 26 uM after 6 to 72 hrs by MTT assay | 2015 | European journal of medicinal chemistry, Sep-18, Volume: 102 | Thiazole compounds with activity against Cryptococcus gattii and Cryptococcus neoformans in vitro. |
| AID1472843 | Antifungal activity against Candida albicans ATCC 10231 at 7.8 ug/mL incubated for 1 hr by propidium iodide staining-based fluorescence microscopic method | 2018 | Journal of medicinal chemistry, 01-11, Volume: 61, Issue:1 | Alkylated Piperazines and Piperazine-Azole Hybrids as Antifungal Agents. |
| AID766647 | Antifungal activity against Candida albicans MTCC 3958 after 24 hrs by well diffusion method | 2013 | European journal of medicinal chemistry, Sep, Volume: 67 | Total synthesis and biological evaluation of clavaminol-G and its analogs. |
| AID42875 | Inhibition of Candida krusei ATCC 6258 growth for 48 hours in vitro. | 2001 | Journal of medicinal chemistry, Aug-16, Volume: 44, Issue:17 | 3-Phenyl-5-acyloxymethyl-2H,5H-furan-2-ones: synthesis and biological activity of a novel group of potential antifungal drugs. |
| AID719445 | Antifungal activity against Candida albicans MTCC 3017 at 500 ug/mL after 72 hrs by well plate method | 2012 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 22, Issue:24 | Synthesis, antioxidant and antimicrobial activity of novel vanillin derived piperidin-4-one oxime esters: preponderant role of the phenyl ester substituents on the piperidin-4-one oxime core. |
| AID1732430 | Antifungal activity against Cryptococcus neoformans var. grubii ATCC 208821) assessed as growth inhibition after 36 hrs by monochromator plate assay relative to control | 2021 | Bioorganic & medicinal chemistry letters, 05-01, Volume: 39 | Design, synthesis and bioactivity evaluation of novel pyrazole linked phenylthiazole derivatives in context of antibacterial activity. |
| AID1728458 | Antifungal activity against Candida glabrata ATCC 0001 assessed as inhibition of microbial growth by NCCLS protocol based method | 2021 | European journal of medicinal chemistry, Jan-15, Volume: 210 | Novel naphthylamide derivatives as dual-target antifungal inhibitors: Design, synthesis and biological evaluation. |
| AID1494173 | Antifungal activity against Candida albicans ATCC 10231 measured after 48 hrs by CLSI M27-A3 protocol based method | 2018 | Bioorganic & medicinal chemistry, 02-01, Volume: 26, Issue:3 | Novel fluconazole derivatives with promising antifungal activity. |
| AID1113444 | Antifungal activity against Candida albicans assessed as growth inhibition at 50 ug/ml by cup-plate method (Rvb = 8 to 10 mm) | 2013 | Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents, , Volume: 22, Issue:4 | Synthesis and biological evaluation of 2-(5-substituted-1-((diethylamino)methyl)-2-oxoindolin-3-ylidene)- |
| AID542086 | Antifungal activity against Candida glabrata ATCC 200918 after 24 hrs by microdilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Discovery of a small-molecule inhibitor of {beta}-1,6-glucan synthesis. |
| AID1367151 | Antifungal activity against Candida tropicalis 156 after 24 hrs by microdilution broth method | 2017 | Bioorganic & medicinal chemistry letters, 12-01, Volume: 27, Issue:23 | Synthesis and biological evolution of hydrazones derived from 4-(trifluoromethyl)benzohydrazide. |
| AID1743170 | Antifungal activity against Trichophyton mentagrophytes var. interdigitale | 2020 | European journal of medicinal chemistry, Dec-15, Volume: 208 | Multiple biological active 4-aminopyrazoles containing trifluoromethyl and their 4-nitroso-precursors: Synthesis and evaluation. |
| AID424632 | Antimicrobial activity against azole-susceptible Candida albicans isolate CA129 co-treated with calcineurin signaling inhibitor tacrolimus after 48 hrs by microdilution checkerboard technique | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | In vitro interactions between tacrolimus and azoles against Candida albicans determined by different methods. |
| AID424896 | Antimicrobial activity against azole-resistant Candida albicans isolate CA10 assessed as growth at 32 ug/ml cotreated with 0.016 ug/ml calcineurin signaling inhibitor Tacrolimus after 48 hrs by microdilution checkboard technique relative to control | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | In vitro interactions between tacrolimus and azoles against Candida albicans determined by different methods. |
| AID567429 | Antifungal activity against Dipodascus capitatus after 48 hrs by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | In vitro antifungal activities of isavuconazole and comparators against rare yeast pathogens. |
| AID1394702 | Antifungal activity against fluconazole-resistant Candida albicans ATCC MYA-573 after overnight incubation by CLSI broth microdilution method | 2018 | European journal of medicinal chemistry, Apr-25, Volume: 150 | Structure-activity relationship studies of ultra-short peptides with potent activities against fluconazole-resistant Candida albicans. |
| AID1329219 | Antifungal activity against fluconazole-resistant Candida albicans clinical isolate 145 by CLSI broth microdilution method | 2016 | Journal of natural products, 09-23, Volume: 79, Issue:9 | Heptaketides from an Endolichenic Fungus Biatriospora sp. and Their Antifungal Activity. |
| AID521503 | Antifungal activity against Cryptococcus neoformans ATCC 90113 after 72 hrs by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | In vitro and in vivo antifungal activities of T-2307, a novel arylamidine. |
| AID582796 | Antifungal activity against Candida albicans isolate 6 by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | Identification and characterization of four azole-resistant erg3 mutants of Candida albicans. |
| AID478532 | Antimicrobial activity against Saccharomyces cerevisiae ATCC 9763 after 24 hrs by broth microdilution assay | 2010 | European journal of medicinal chemistry, May, Volume: 45, Issue:5 | Synthesis of some novel 2-substituted-5-[isopropylthiazole] clubbed 1,2,4-triazole and 1,3,4-oxadiazoles as potential antimicrobial and antitubercular agents. |
| AID642911 | Antifungal activity against Candida albicans ATCC 60193 | 2011 | ACS medicinal chemistry letters, May-12, Volume: 2, Issue:5 | Natural Product Based 6-Hydroxy-2,3,4,6-tetrahydropyrrolo[1,2-a]pyrimidinium Scaffold as A New Antifungal Template. |
| AID595738 | Antimicrobial activity against Microsporum gypseum after 48 hrs by broth microdilution method | 2011 | European journal of medicinal chemistry, May, Volume: 46, Issue:5 | Design, synthesis and in vitro antimicrobial evaluation of novel Imidazo[1,2-a]pyridine and imidazo[2,1-b][1,3]benzothiazole motifs. |
| AID1180454 | Antimicrobial activity against Trichophyton mentagrophytes 445 after 120 hrs by microdilution method | 2014 | Bioorganic & medicinal chemistry, Aug-01, Volume: 22, Issue:15 | Synthesis and biological activity of new salicylanilide N,N-disubstituted carbamates and thiocarbamates. |
| AID493523 | Antifungal activity against Absidia corymbifera 272 after 24 hrs by broth microdilution assay | 2010 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 20, Issue:15 | N-Benzylsalicylthioamides as novel compounds with promising antimycotic activity. |
| AID1595082 | Antifungal activity against Candida glabrata assessed as reduction in fungal cell growth incubated for 24 hrs by broth microdilution method | 2019 | European journal of medicinal chemistry, May-15, Volume: 170 | Tetrazole hybrids and their antifungal activities. |
| AID547566 | Antifungal activity against Candida parapsilosis after 24 to 72 hrs by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | In vitro antifungal activities of bis(alkylpyridinium)alkane compounds against pathogenic yeasts and molds. |
| AID584370 | Ratio of CDR1 gene expression in Candida glabrata isolated from patient 002 receiving antifungal drug to CDR1 gene expression in Candida glabrata isolated from patient 002 by RT-PCR analysis | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Impact of antifungal prophylaxis on colonization and azole susceptibility of Candida species. |
| AID405105 | Antimicrobial activity against Rhizopus microsporus var. rhizopodiformis assessed as percent of susceptible isolates after 24 hrs | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | In vitro susceptibilities of 217 clinical isolates of zygomycetes to conventional and new antifungal agents. |
| AID1740332 | Antifungal activity against Penicillium chrysogenum ATCC 10106 assessed as reduction in fungal growth incubated for 48 hrs by broth microdilution method | 2020 | European journal of medicinal chemistry, Sep-15, Volume: 202 | Design, synthesis and antimicrobial evaluation of novel glycosylated-fluoroquinolones derivatives. |
| AID1272750 | Antifungal activity against Penicillium citrinum at 0.25 mol/L after 2 to 4 days by paper disc method | 2016 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 26, Issue:3 | Synthesis, antimicrobial activity of Schiff base compounds of cinnamaldehyde and amino acids. |
| AID581886 | Antifungal activity against Saccharomyces cerevisiae isolated from HSCT recipient 513 with acute or chronic GVHD mouth after 112 days prophylaxis by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Impact of antifungal prophylaxis on colonization and azole susceptibility of Candida species. |
| AID48961 | Tested in vitro for the minimum inhibitory concentration (MIC) against Candida albicans SANK51486 | 2002 | Bioorganic & medicinal chemistry letters, Mar-11, Volume: 12, Issue:5 | Synthesis of Sordaricin analogues as potent antifungal agents against Candida albicans. |
| AID1556220 | Inhibition of CYP51 in Candida albicans ATCC SC5314 assessed as obtusifoliol level at 0.5 ug/ml incubated for 16 hrs by GC/MS analysis (Rvb = 0%) | 2019 | European journal of medicinal chemistry, Sep-01, Volume: 177 | Design, synthesis, and structure-activity relationship studies of l-amino alcohol derivatives as broad-spectrum antifungal agents. |
| AID1059366 | Antifungal activity against Candida albicans after 20 hrs by agar dilution method | 2013 | European journal of medicinal chemistry, , Volume: 70 | Designing and synthesis of novel antimicrobial heterocyclic analogs of fatty acids. |
| AID462258 | Antifungal activity against pharmacoresistant Candida albicans AIDS68 infected in Wistar rat estrogen-dependent fungal vaginitis model assessed as fungal burden at 10 ug administered intravaginally 48 hrs after fungal infection measured on day 14 after in | 2010 | Journal of medicinal chemistry, Mar-25, Volume: 53, Issue:6 | Identification of inhibitors of drug-resistant Candida albicans strains from a library of bicyclic peptidomimetic compounds. |
| AID1904263 | Antifungal activity against Candida auris 0029 assessed as inhibition of fungal growth incubated for 48 hrs by microdilution method | 2022 | Journal of medicinal chemistry, 05-12, Volume: 65, Issue:9 | Discovery of Novel Sertraline Derivatives as Potent Anti- |
| AID48084 | Evaluation of In vitro antifungal activity against yeasts by broth macro dilution method | 1995 | Journal of medicinal chemistry, Sep-29, Volume: 38, Issue:20 | Synthesis and antifungal activity of new azole derivatives containing an N-acylmorpholine ring. |
| AID518439 | Antimicrobial activity against Cryptococcus gattii serotype B isolate NIH409 assessed as heteroresistant isolates at 4 ug/ml | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Heteroresistance of Cryptococcus gattii to fluconazole. |
| AID1254315 | Antifungal activity against Candida albicans ATCC 44859 after 48 hrs by microdilution broth method | 2015 | Bioorganic & medicinal chemistry, Nov-15, Volume: 23, Issue:22 | Novel derivatives of nitro-substituted salicylic acids: Synthesis, antimicrobial activity and cytotoxicity. |
| AID1758041 | Inhibition of CYP51 in Candida albicans ATCC SC5314 assessed as Eburicol level at 0.03125 ug/ml after 16 hrs by GC-MS analysis (Rvb = 0%) | 2021 | European journal of medicinal chemistry, Apr-15, Volume: 216 | Lead optimization generates selenium-containing miconazole CYP51 inhibitors with improved pharmacological profile for the treatment of fungal infections. |
| AID118059 | In vivo evaluation of % survival rate after peroral administration on 5th day at dose 2.5 mg/kg | 1995 | Journal of medicinal chemistry, Sep-29, Volume: 38, Issue:20 | Synthesis and antifungal activity of new azole derivatives containing an N-acylmorpholine ring. |
| AID537734 | Antifungal activity against yeast AD1-8u expressing Candida albicans CaMdr1p by agar disk diffusion assay | 2010 | European journal of medicinal chemistry, Nov, Volume: 45, Issue:11 | Analysis of physico-chemical properties of substrates of ABC and MFS multidrug transporters of pathogenic Candida albicans. |
| AID1439297 | Antifungal activity against Aspergillus fumigatus after 24 hrs by serial dilution method | 2017 | European journal of medicinal chemistry, Mar-10, Volume: 128 | Tetrazolylmethyl quinolines: Design, docking studies, synthesis, anticancer and antifungal analyses. |
| AID1551798 | Antibacterial activity against Bacillus cereus ATCC 10876 after 24 hrs by microdilution method | 2019 | European journal of medicinal chemistry, Jul-01, Volume: 173 | Antibacterial activity study of 1,2,4-triazole derivatives. |
| AID554997 | Antifungal activity against Candida tropicalis assessed as dose dependent percent susceptible isolates at 25 ug/disc by CLSI M44-A disk diffusion method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | In vitro activities of fluconazole and voriconazole against clinical isolates of Candida spp. determined by disk diffusion testing in Turin, Italy. |
| AID1689227 | Antifungal activity against Aspergillus fumigatus NR 35304 assessed as reduction in fungal growth incubated for 24 hrs by CLSI based broth microdilution method | 2020 | European journal of medicinal chemistry, Mar-01, Volume: 189 | Oxadiazolylthiazoles as novel and selective antifungal agents. |
| AID530958 | Antifungal activity against Cryptococcus neoformans ATCC 66031 after 72 hrs by CLSI method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Potent in vitro antifungal activities of naturally occurring acetylenic acids. |
| AID1391294 | Antifungal activity against wild-type fluconazole-sensitive Cryptococcus neoformans serotype D B3501 measured over 4 days | 2018 | Bioorganic & medicinal chemistry, 05-15, Volume: 26, Issue:9 | Synthesis and biological evaluation of aminothiazoles against Histoplasma capsulatum and Cryptococcus neoformans. |
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| AID598222 | Antimicrobial activity against Candida albicans isolate 31 after 48 hrs by microdilution broth method | 2011 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 21, Issue:11 | Synthesis and in vitro antimicrobial activities of new (cyano-NNO-azoxy)pyrazole derivatives. |
| AID1584742 | Drug metabolism in rat liver microsome S9 fraction assessed as CYP450-mediated metabolism by measuring compound remaining at 5 uM pretreated with NADPH and measured after 60 mins by UPLC-MS/MS analysis | 2018 | Journal of medicinal chemistry, 10-25, Volume: 61, Issue:20 | Discovery of Novel 7-Aryl 7-Deazapurine 3'-Deoxy-ribofuranosyl Nucleosides with Potent Activity against Trypanosoma cruzi. |
| AID525600 | Antibacterial activity against Fluconazole resistant Candida albicans DSY3604 containing tac1delta/delta ERG11-1/ERG11-5 genotype by EUCAST standards based broth microdilution method sCandida albicans DSY294 | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Genetic dissection of azole resistance mechanisms in Candida albicans and their validation in a mouse model of disseminated infection. |
| AID371468 | Antimicrobial activity against Candida albicans isolate after 24 to 48 hrs after 24 hrs by disk diffusion method | 2008 | European journal of medicinal chemistry, Jul, Volume: 43, Issue:7 | Synthesis and biological activity of some new benzoxazoles. |
| AID1059363 | Antifungal activity against Candida krusei after 20 hrs by agar dilution method | 2013 | European journal of medicinal chemistry, , Volume: 70 | Designing and synthesis of novel antimicrobial heterocyclic analogs of fatty acids. |
| AID521973 | Antibacterial activity against azole-susceptible Candida albicans DSY294 containing CIp10 to restore URA3 function infected in BALB/c mouse assessed as effect on infection outcome score administered intraperitoneally 1 hr post bacterial challenge measured | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Genetic dissection of azole resistance mechanisms in Candida albicans and their validation in a mouse model of disseminated infection. |
| AID1352429 | Antifungal activity against drug-resistant Aspergillus fumigatus by CLSI two fold serial dilution method | 2018 | European journal of medicinal chemistry, Feb-25, Volume: 146 | Discovery of 2-aminothiazolyl berberine derivatives as effectively antibacterial agents toward clinically drug-resistant Gram-negative Acinetobacter baumanii. |
| AID1480832 | Anti-fungal activity against Candida krusei ATCC 6258 after 48 hrs by broth microdilution method | 2017 | European journal of medicinal chemistry, Apr-21, Volume: 130 | New azole derivatives showing antimicrobial effects and their mechanism of antifungal activity by molecular modeling studies. |
| AID525544 | Antimicrobial activity against Fonsecaea nubica isolates after 72 hrs by CLSI M38-A2 protocol method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | In vitro activities of eight antifungal drugs against 55 clinical isolates of Fonsecaea spp. |
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| AID371227 | Antimicrobial activity against Candida albicans SANK 51486 by broth microdilution method | 2008 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 18, Issue:24 | Carbon analogs of antifungal dioxane-triazole derivatives: synthesis and in vitro activities. |
| AID626344 | Antifungal activity against Aspergillus flavus MTCC 3306 at 0.5 mg/mL after 72 hrs by by agar-well diffusion method | 2011 | European journal of medicinal chemistry, Nov, Volume: 46, Issue:11 | Hantzsch reaction: synthesis and characterization of some new 1,4-dihydropyridine derivatives as potent antimicrobial and antioxidant agents. |
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| AID369396 | Antimicrobial activity against Trichosporon mucoides isolate | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | In vitro susceptibility to posaconazole of 1,903 yeast isolates recovered in France from 2003 to 2006 and tested by the method of the European committee on antimicrobial susceptibility testing. |
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| AID665072 | Antifungal activity against Trichophyton rubrum by serial dilution method | 2012 | European journal of medicinal chemistry, Jul, Volume: 53 | Design, synthesis and structure-activity relationships of new triazole derivatives containing N-substituted phenoxypropylamino side chains. |
| AID356363 | Antifungal activity against fluconazole-resistant Candida albicans isolate 17 after 24 to 48 hrs by NCCLS method | 2003 | Journal of natural products, Aug, Volume: 66, Issue:8 | Acetylenic acids inhibiting azole-resistant Candida albicans from Pentagonia gigantifolia. |
| AID276387 | Antifungal activity against Candida albicans by broth microdilution technique | 2006 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 16, Issue:22 | Naphtho[2,3-b][1,4]-thiazine-5,10-diones and 3-substituted-1,4-dioxo-1,4-dihydronaphthalen-2-yl-thioalkanoate derivatives: synthesis and biological evaluation as potential antibacterial and antifungal agents. |
| AID531237 | Antifungal activity against Candida guilliermondii after 48 hrs by CLSI method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | In vitro susceptibilities of invasive isolates of Candida species: rapid increase in rates of fluconazole susceptible-dose dependent Candida glabrata isolates. |
| AID750203 | Antifungal activity against Candida guilliermondii after 48 hrs by CLSI M27A3 broth microdilution method | 2013 | European journal of medicinal chemistry, Jun, Volume: 64 | Synthesis, antifungal and cytotoxic activities of 2-aryl-3-((piperidin-1-yl)ethyl)thiazolidinones. |
| AID1524623 | Antibacterial activity against Streptococcus mutans 3289 after 24 hrs by microtiter ELISA | 2019 | Bioorganic & medicinal chemistry letters, 05-01, Volume: 29, Issue:9 | Synthesis of novel dihydrotriazine derivatives bearing 1,3-diaryl pyrazole moieties as potential antibacterial agents. |
| AID1783774 | Antifungal activity against Aspergillus fumigatus CGMCC3.7795 assessed as inhibition of fungal growth by NCCLS protocol based method | 2021 | European journal of medicinal chemistry, Nov-15, Volume: 224 | Improving the metabolic stability of antifungal compounds based on a scaffold hopping strategy: Design, synthesis, and structure-activity relationship studies of dihydrooxazole derivatives. |
| AID274122 | Antifungal activity against Candida parapsilosis after 24 hrs | 2006 | Bioorganic & medicinal chemistry letters, Oct-15, Volume: 16, Issue:20 | Design, synthesis, and antifungal activities in vitro of novel tetrahydroisoquinoline compounds based on the structure of lanosterol 14alpha-demethylase (CYP51) of fungi. |
| AID544871 | Antimicrobial activity against Candida albicans harboring MRR1 gene by microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | Gain-of-function mutations in the transcription factor MRR1 are responsible for overexpression of the MDR1 efflux pump in fluconazole-resistant Candida dubliniensis strains. |
| AID750757 | Antifungal activity against Trichoderma viride MTCC 1107 after 48 hrs | 2013 | European journal of medicinal chemistry, Jun, Volume: 64 | Biological activity, design, synthesis and structure activity relationship of some novel derivatives of curcumin containing sulfonamides. |
| AID1367157 | Antifungal activity against Trichophyton mentagrophytes 445 after 72 hrs by microdilution broth method | 2017 | Bioorganic & medicinal chemistry letters, 12-01, Volume: 27, Issue:23 | Synthesis and biological evolution of hydrazones derived from 4-(trifluoromethyl)benzohydrazide. |
| AID518893 | Antimicrobial activity against Cryptococcus gattii serotype C isolate H0058-1-1941 assessed as heteroresistant isolates at 32 ug/ml | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Heteroresistance of Cryptococcus gattii to fluconazole. |
| AID670556 | Antifungal activity against Candida albicans MTCC 854 after 24 hrs by well diffusion method | 2012 | Bioorganic & medicinal chemistry letters, Jul-15, Volume: 22, Issue:14 | Total synthesis and antifungal activity of (2S,3R)-2-aminododecan-3-ol. |
| AID1244346 | Antifungal activity against Aspergillus fumigatus incubated for 48 hrs by broth micro-dilution method | 2015 | European journal of medicinal chemistry, Aug-28, Volume: 101 | N-Alkyl/aryl-4-(3-substituted-3-phenylpropyl)piperazine-1-carbothioamide as dual-action vaginal microbicides with reverse transcriptase inhibition. |
| AID493515 | Antifungal activity against Candida krusei E28 after 24 hrs by broth microdilution assay | 2010 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 20, Issue:15 | N-Benzylsalicylthioamides as novel compounds with promising antimycotic activity. |
| AID772322 | Antifungal activity against fluconazole-resistant Candida albicans DSY751 harboring ERG11 gene mutant and increase expressing of MDR1 gene after 24 hrs by visually and spectrophotometric analysis | 2013 | ACS medicinal chemistry letters, Sep-12, Volume: 4, Issue:9 | Novel Macrocyclic Amidinoureas: Potent Non-Azole Antifungals Active against Wild-Type and Resistant Candida Species. |
| AID1493861 | Antifungal activity against Candida albicans infected in Sprague-Dawley rat vaginal infection model assessed as reduction in vaginal fungal burden at 1 mg/kg, administered intravaginally on day 1 to day 3 post fungal inoculation measured on day 4 | 2018 | European journal of medicinal chemistry, Jan-01, Volume: 143 | Discovery of simplified sampangine derivatives as novel fungal biofilm inhibitors. |
| AID416740 | Antifungal activity against Candida albicans MTCC 227 by serial dilution method | 2009 | European journal of medicinal chemistry, Feb, Volume: 44, Issue:2 | Hansch analysis of veratric acid derivatives as antimicrobial agents. |
| AID750761 | Antifungal activity against Curvularia lunata MTCC 581 after 48 hrs | 2013 | European journal of medicinal chemistry, Jun, Volume: 64 | Biological activity, design, synthesis and structure activity relationship of some novel derivatives of curcumin containing sulfonamides. |
| AID1416195 | Antifungal activity against Aspergillus flavus by two-fold serial dilution method | 2017 | MedChemComm, Aug-01, Volume: 8, Issue:8 | Discovery of potential antifungal triazoles: design, synthesis, biological evaluation, and preliminary antifungal mechanism exploration. |
| AID542084 | Antifungal activity against Candida albicans ATCC MYA-573 after 24 hrs by microdilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Discovery of a small-molecule inhibitor of {beta}-1,6-glucan synthesis. |
| AID1546132 | Antibacterial activity against Bacillus subtilis ATCC 21216 after 24 hrs by two-fold broth serial dilution method | 2019 | European journal of medicinal chemistry, Dec-15, Volume: 184 | Current scenario of tetrazole hybrids for antibacterial activity. |
| AID1592222 | Antifungal activity against Candida albicans assessed as reduction in cell division at 25 to 250 nM/mL by polarizing microscopy | 2019 | Bioorganic & medicinal chemistry, 06-15, Volume: 27, Issue:12 | Design, synthesis and biological evaluation of amide-pyridine derivatives as novel dual-target (SE, CYP51) antifungal inhibitors. |
| AID428422 | Antifungal activity against Microsporum canis after 48 hrs by agar dilution method | 2009 | European journal of medicinal chemistry, Jul, Volume: 44, Issue:7 | Design, synthesis, and antifungal activity of triazole and benzotriazole derivatives. |
| AID1877874 | Cytotoxicity against human 16HBE by MTS assay | 2022 | Bioorganic & medicinal chemistry letters, 02-15, Volume: 58 | Synthesis and antifungal evaluation of phenol-derived bis(indolyl)methanes combined with FLC against Candida albicans. |
| AID448160 | Antimicrobial activity against Staphylococcus aureus ATCC 25923 at 5 ug after 18 hrs by well diffusion method | 2009 | European journal of medicinal chemistry, Nov, Volume: 44, Issue:11 | Synthesis of some new 1,2,4-triazoles starting from isonicotinic acid hydrazide and evaluation of their antimicrobial activities. |
| AID1465990 | Antifungal activity against Aspergillus fumigatus NR-35301 after 68 hrs by broth dilution assay | 2017 | Bioorganic & medicinal chemistry, 06-01, Volume: 25, Issue:11 | Investigation of aryl isonitrile compounds with potent, broad-spectrum antifungal activity. |
| AID1905255 | Synergistic antifungal activity against fluconazole-resistant Candida albicans 100 assessed as inhibition of fungal growth in presence of fluconazole by checker board microdilution assay | 2022 | Journal of medicinal chemistry, 04-14, Volume: 65, Issue:7 | Species-Selective Targeting of Fungal Hsp90: Design, Synthesis, and Evaluation of Novel 4,5-Diarylisoxazole Derivatives for the Combination Treatment of Azole-Resistant Candidiasis. |
| AID441340 | Antifungal activity against Rhizopus oryzae NRRL 21498 | 2009 | European journal of medicinal chemistry, Dec, Volume: 44, Issue:12 | Synthesis of 6-aminomethyl derivatives of benzopyran-4-one with dual biological properties: anti-inflammatory-analgesic and antimicrobial. |
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| AID1695838 | Antifungal activity against Candida albicans MTCC 227 incubated for 2 days by microdilution method | 2019 | European journal of medicinal chemistry, Apr-15, Volume: 168 | Comprehensive review on the anti-bacterial activity of 1,2,3-triazole hybrids. |
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| AID582238 | Antifungal activity against Candida krusei isolated from neutropenic subjects with AML or MDS prior to initiation of posaconazole therapy assessed as maximum MIC by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Impact of antifungal prophylaxis on colonization and azole susceptibility of Candida species. |
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| AID527145 | Antifungal activity against Cryptococcus gattii LMGO L1 after 5 days microdilution technique | 2010 | Journal of natural products, Oct-22, Volume: 73, Issue:10 | Search for antifungal compounds from the wood of durable tropical trees. |
| AID569363 | Antifungal activity against Aspergillus niger at 500 ug after 24 hrs by paper disc technique | 2011 | European journal of medicinal chemistry, Feb, Volume: 46, Issue:2 | Efficient and novel one-pot synthesis of antifungal active 1-substituted-8-aryl-3-alkyl/aryl-4H-pyrazolo[4,5-f][1,2,4]triazolo[4,3-b][1,2,4]triazepines using solid support. |
| AID637216 | Antifungal activity against Candida albicans MTCC 227 after 48 hrs by tube dilution method hrs followed by subculturing | 2012 | European journal of medicinal chemistry, Feb, Volume: 48 | Synthesis, antimicrobial, anticancer evaluation and QSAR studies of 6-methyl-4-[1-(2-substituted-phenylamino-acetyl)-1H-indol-3-yl]-2-oxo/thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid ethyl esters. |
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| AID1474177 | Inhibition of CYP51 in Candida albicans ATCC SC5314 assessed as lanosterol composition of the total sterol fraction in membrane at 8 ug/ml after 16 hrs by GC-MS analysis (Rvb = 2.9%) | 2016 | European journal of medicinal chemistry, Nov-10, Volume: 123 | Design, synthesis, and structure-activity relationship studies of benzothiazole derivatives as antifungal agents. |
| AID751634 | Antifungal activity against Candida albicans at 100 ppm | 2013 | European journal of medicinal chemistry, Feb, Volume: 60 | Synthesis and antifungal activity of some s-mercaptotriazolobenzothiazolyl amino acid derivatives. |
| AID1550457 | Antifungal activity against Candida guilliermondii IBA 155 assessed as decrease in fungal cell growth incubated for 24 hrs by E-test | 2019 | European journal of medicinal chemistry, Jun-01, Volume: 171 | Antimicrobial and KPC/AmpC inhibitory activity of functionalized benzosiloxaboroles. |
| AID1867445 | Induction of ROS generation in fluconazole resistant Candida glabrata 109 overexpressing CgCdr1p transporter assessed as increase in ROS level incubated for 90 mins by DCFH-DA dye based fluorescence assay | 2022 | Bioorganic & medicinal chemistry, 06-01, Volume: 63 | Effects of β-lapachone and β-nor-lapachone on multidrug efflux transporters and biofilms of Candida glabrata. |
| AID1379939 | Antifungal activity against Candida krusei clinical isolates assessed as inhibition of microbial growth incubated for 24 hrs by broth microdilution method | 2017 | European journal of medicinal chemistry, Nov-10, Volume: 140 | Synthesis, biological evaluation and quantitative structure-active relationships of 1,3-thiazolidin-4-one derivatives. A promising chemical scaffold endowed with high antifungal potency and low cytotoxicity. |
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| AID424887 | Antimicrobial activity against azole-resistant Candida albicans isolate CA10 assessed as growth at 128 ug/ml co-treated with 0.031 ug/ml calcineurin signaling inhibitor tacrolimus after 48 hrs by microdilution checkboard technique relative to control | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | In vitro interactions between tacrolimus and azoles against Candida albicans determined by different methods. |
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| AID1185707 | Antimicrobial activity against Saccharomyces cerevisiae RSKK 251 after 24 hrs by agar dilution method | 2014 | European journal of medicinal chemistry, Sep-12, Volume: 84 | New thiophene-1,2,4-triazole-5(3)-ones: highly bioactive thiosemicarbazides, structures of Schiff bases and triazole-thiols. |
| AID429397 | Antifungal activity against Geotrichum candidum MTCC 3993 after 24 to 72 hrs by broth dilution method | 2009 | European journal of medicinal chemistry, Aug, Volume: 44, Issue:8 | Mechanism of unusual formation of 3-(5-phenyl-3H-[1,2,4]dithiazol-3-yl)chromen-4-ones and 4-oxo-4H-chromene-3-carbothioic acid N-phenylamides and their antimicrobial evaluation. |
| AID712902 | Antifungal activity against Aspergillus niger after 72 hrs by broth dilution method | 2012 | European journal of medicinal chemistry, Aug, Volume: 54 | Synthesis and evaluation of antimicrobial activity of 4H-pyrimido[2,1-b]benzothiazole, pyrazole and benzylidene derivatives of curcumin. |
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| AID1157180 | Antifungal activity against Candida albicans PMC 1040R after 48 hrs by CLSI broth microdilution method | 2014 | European journal of medicinal chemistry, Aug-18, Volume: 83 | Synthesis, biological evaluation and structure-activity correlation study of a series of imidazol-based compounds as Candida albicans inhibitors. |
| AID340950 | Antifungal activity against Candida albicans isolates from HIV infected patient during fluconazole therapy by NCCLS M27-A2 method | 2007 | Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8 | Cross-resistance to medical and agricultural azole drugs in yeasts from the oropharynx of human immunodeficiency virus patients and from environmental Bavarian vine grapes. |
| AID1493835 | Antifungal activity against fluconazole-resistant Candida albicans clinical isolate 032 after 24 hrs by spectrophotometric analysis | 2018 | European journal of medicinal chemistry, Jan-01, Volume: 143 | Discovery of simplified sampangine derivatives as novel fungal biofilm inhibitors. |
| AID519686 | Antimicrobial activity against Saccharomyces cerevisiae containing disruption in MEF2 gene by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Genomewide screening for genes associated with gliotoxin resistance and sensitivity in Saccharomyces cerevisiae. |
| AID554724 | Fold resistant, ratio of MIC for Saccharomyces cerevisiae isolate ADdelta overexpressing Candida krusei ERG11C to MIC for Saccharomyces cerevisiae isolate ADdelta overexpressing Abc1p | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Abc1p is a multidrug efflux transporter that tips the balance in favor of innate azole resistance in Candida krusei. |
| AID1818280 | Induction of apoptosis against Candida albicans ATCC SC5314 assessed as viable cells measured after 48 hrs by by Annexin V-FITC/propidium iodide staining based flow cytometry (Rvb = 80.78 %) | |||
| AID1864877 | Antifungal activity against Candida albicans ATCC SC5314 assessed as fungal growth inhibition measured after 72 hrs by double dilution method | |||
| AID348335 | Antifungal activity against Trichophyton mentagrophytes after 72 hrs | 2008 | European journal of medicinal chemistry, May, Volume: 43, Issue:5 | Synthesis and antimycobacterial evaluation of substituted pyrazinecarboxamides. |
| AID608756 | Antifungal activity against Trichophyton rubrum at 1000 ug/ml after 72 hrs by agar diffusion method | 2011 | European journal of medicinal chemistry, Aug, Volume: 46, Issue:8 | Synthesis, characterization and antimicrobial studies of some new pyrazole incorporated imidazole derivatives. |
| AID1138328 | Antimicrobial activity against Candida albicans Y0109 after 24 hrs by serial dilution method | 2014 | Journal of medicinal chemistry, May-08, Volume: 57, Issue:9 | Design, synthesis, and structure-activity relationship studies of novel fused heterocycles-linked triazoles with good activity and water solubility. |
| AID1221958 | Efflux ratio of permeability from apical to basolateral side over basolateral to apical side of human Caco2 cells at 10 uM up to 120 mins by HPLC-MC analysis | 2011 | Drug metabolism and disposition: the biological fate of chemicals, Feb, Volume: 39, Issue:2 | Attenuation of intestinal absorption by major efflux transporters: quantitative tools and strategies using a Caco-2 model. |
| AID510327 | Antifungal activity against Aspergillus fumigatus ATCC 96918 after 24 hrs by micro-broth dilution method | 2010 | European journal of medicinal chemistry, Sep, Volume: 45, Issue:9 | Synthesis and biological activities of novel amine-derived bis-azoles as potential antibacterial and antifungal agents. |
| AID424638 | Antimicrobial activity against azole-resistant Candida albicans isolate CA10 assessed as growth at 0.125 ug/ml cotreated with 0.125 ug/ml calcineurin signaling inhibitor Tacrolimus after 48 hrs by microdilution checkboard technique relative to control | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | In vitro interactions between tacrolimus and azoles against Candida albicans determined by different methods. |
| AID1600171 | Antifungal activity against Candida albicans NCIM 3100 assessed as inhibition of fungal growth incubated for 48 to 72 hrs by broth microdilution susceptibility method | 2019 | European journal of medicinal chemistry, Oct-01, Volume: 179 | Synthesis of new thiazolyl-pyrazolyl-1,2,3-triazole derivatives as potential antimicrobial agents. |
| AID1546139 | Antifungal activity against Aspergillus flavus after 24 hrs | 2019 | European journal of medicinal chemistry, Dec-15, Volume: 184 | Current scenario of tetrazole hybrids for antibacterial activity. |
| AID320388 | Antimicrobial activity against Fusarium oxysporum NCL5 by broth microdilution method | 2008 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 18, Issue:6 | Synthesis and antimicrobial activity of beta-lactam-bile acid conjugates linked via triazole. |
| AID546071 | Antifungal activity against Clavispora lusitaniae isolated from candidemia patient by AFST-EUCAST microdilution method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | A 10-year survey of antifungal susceptibility of candidemia isolates from intensive care unit patients in Greece. |
| AID1191519 | Antibacterial activity against Trichosporon asahii 1188 after 24 hrs by broth microdilution method | 2015 | Bioorganic & medicinal chemistry, Feb-15, Volume: 23, Issue:4 | Synthesis and in vitro biological evaluation of 2-(phenylcarbamoyl)phenyl 4-substituted benzoates. |
| AID1758007 | Antifungal activity against Candida parapsilosis ATCC 22019 measured after 24 hrs by broth microdilution assay | 2021 | European journal of medicinal chemistry, Apr-15, Volume: 216 | Lead optimization generates selenium-containing miconazole CYP51 inhibitors with improved pharmacological profile for the treatment of fungal infections. |
| AID1352422 | Antifungal activity against Candida utilis ATCC 9950 by CLSI two fold serial dilution method | 2018 | European journal of medicinal chemistry, Feb-25, Volume: 146 | Discovery of 2-aminothiazolyl berberine derivatives as effectively antibacterial agents toward clinically drug-resistant Gram-negative Acinetobacter baumanii. |
| AID304975 | Antifungal activity against Trichophyton mentagrophytes by broth micro-dilution technique | 2007 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 17, Issue:1 | New antifungal flavonoid glycoside from Vitex negundo. |
| AID420065 | Antifungal activity against Candida albicans PCA-2 after 48 hrs by broth microdilution assay | 2009 | Bioorganic & medicinal chemistry, Jun-01, Volume: 17, Issue:11 | Bulky 1,4-benzoxazine derivatives with antifungal activity. |
| AID642937 | Antifungal activity against Candida albicans ATCC 32354 at 160 ug/ml | 2011 | ACS medicinal chemistry letters, May-12, Volume: 2, Issue:5 | Natural Product Based 6-Hydroxy-2,3,4,6-tetrahydropyrrolo[1,2-a]pyrimidinium Scaffold as A New Antifungal Template. |
| AID406861 | Antimicrobial activity against Candida albicans SC5314 intact biofilms after 48 hrs by XTT assay | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | Role for cell density in antifungal drug resistance in Candida albicans biofilms. |
| AID516308 | Antimicrobial activity against Cryptococcus gattii serotype B isolate NIH200 assessed as concentration required for heteroresistance | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Heteroresistance of Cryptococcus gattii to fluconazole. |
| AID1061737 | Antimicrobial activity against Aspergillus fumigatus by broth microdilution method | 2014 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 24, Issue:1 | Synthesis and evaluation of novel azoles as potent antifungal agents. |
| AID1192374 | Antimicrobial activity against Pseudomonas aeruginosa MTCC 1034 after 18 hrs by broth micro dilution method | 2015 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 25, Issue:7 | Synthesis and antimicrobial activity of novel benzoxazine sulfonamide derivatives. |
| AID294563 | Antimicrobial activity against Pseudomonas aeruginosa ATCC 15442 at 20 ug by disk diffusion method | 2007 | European journal of medicinal chemistry, Jun, Volume: 42, Issue:6 | Rapid synthesis of sulfone derivatives as potential anti-infectious agents. |
| AID420483 | Antifungal activity against Candida albicans after 48 hrs by tube dilution method | 2009 | European journal of medicinal chemistry, May, Volume: 44, Issue:5 | Hansch analysis of substituted benzoic acid benzylidene/furan-2-yl-methylene hydrazides as antimicrobial agents. |
| AID446451 | Antifungal activity against fluconazole-resistant Candida albicans CA424 | 2009 | Bioorganic & medicinal chemistry letters, Oct-15, Volume: 19, Issue:20 | Design of new antifungal agents: synthesis and evaluation of 1-[(1H-indol-5-ylmethyl)amino]-2-phenyl-3-(1H-1,2,4-triazol-1-yl)propan-2-ols. |
| AID613453 | Antifungal activity against Cryptococcus neoformans isolate NCL2 after 72 hrs by broth dilution method | 2011 | European journal of medicinal chemistry, Sep, Volume: 46, Issue:9 | Stereoselective synthesis and antimicrobial activity of steroidal C-20 tertiary alcohols with thiazole/pyridine side chain. |
| AID1419551 | Selectivity index, ratio of EC50 for toxicity in human A549 cells to MIC50 for antifungal activity against ITC and FLC-resistant Candida albicans ATCC MYA-1003 | 2017 | European journal of medicinal chemistry, Jun-16, Volume: 133 | Novel alkylated azoles as potent antifungals. |
| AID1904370 | Antifungal activity against FLC-resistant Candida albicans 103 assessed as fungal growth inhibition by CLSI based serial microbroth dilution method | 2022 | European journal of medicinal chemistry, Apr-05, Volume: 233 | Design, synthesis, and evaluation of novel 3-thiophene derivatives as potent fungistatic and fungicidal reagents based on a conformational restriction strategy. |
| AID525412 | Fungistatic activity against Candida glabrata 4370 assessed as 99.9% reduction of int initial fungal load at 8 times MIC after 48 hrs using colony count method by time-kill method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Posaconazole against Candida glabrata isolates with various susceptibilities to fluconazole. |
| AID563615 | Effect on sterol composition in Candida albicans isolate 108 harboring erg11 and erg5 double mutant assessed as lanosterol level after 2 hrs by gas chromatography | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | A clinical isolate of Candida albicans with mutations in ERG11 (encoding sterol 14alpha-demethylase) and ERG5 (encoding C22 desaturase) is cross resistant to azoles and amphotericin B. |
| AID582230 | Antifungal activity against Candida glabrata isolated from neutropenic subjects with AML or MDS prior to initiation of posaconazole therapy by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Impact of antifungal prophylaxis on colonization and azole susceptibility of Candida species. |
| AID1205750 | Antifungal activity against Cryptococcus gattii L27/01 after 72 hrs by microdilution method | 2015 | ACS medicinal chemistry letters, Mar-12, Volume: 6, Issue:3 | Synthesis of a New Peptide-Coumarin Conjugate: A Potential Agent against Cryptococcosis. |
| AID625287 | Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for hepatomegaly | 2011 | PLoS computational biology, Dec, Volume: 7, Issue:12 | Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). |
| AID407059 | Antimicrobial activity against Candida albicans SC5314 dissociated biofilms grown on silicone-elastomer coated latex surface at cell density of 10'8 cells/ml at 0.25 to 8 ug/ml by XTT assay | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | Role for cell density in antifungal drug resistance in Candida albicans biofilms. |
| AID436282 | Antifungal activity against Aspergillus fumigatus ATCC 10894 by alamar blue assay | 2008 | Journal of natural products, Nov, Volume: 71, Issue:11 | Pestalazines and pestalamides, bioactive metabolites from the plant pathogenic fungus Pestalotiopsis theae. |
| AID567441 | Antifungal activity against Trichosporon domesticum after 48 hrs by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | In vitro antifungal activities of isavuconazole and comparators against rare yeast pathogens. |
| AID1556230 | Inhibition of CYP51 in Candida albicans ATCC SC5314 assessed as eburicol level at 8 ug/ml incubated for 16 hrs by GC/MS analysis (Rvb = 0%) | 2019 | European journal of medicinal chemistry, Sep-01, Volume: 177 | Design, synthesis, and structure-activity relationship studies of l-amino alcohol derivatives as broad-spectrum antifungal agents. |
| AID1368417 | Binding affinity to Mycobacterium tuberculosis CYP121A1 assessed as high spin signal at 2 mM after 20 mins by EPR spectroscopic method (Rvb = 2.5%) | 2018 | Bioorganic & medicinal chemistry, 01-01, Volume: 26, Issue:1 | Design, synthesis and evaluation against Mycobacterium tuberculosis of azole piperazine derivatives as dicyclotyrosine (cYY) mimics. |
| AID545716 | Antifungal activity against Candida parapsilosis after 24 hrs by serial dilution method | 2010 | European journal of medicinal chemistry, Dec, Volume: 45, Issue:12 | Novel conformationally restricted triazole derivatives with potent antifungal activity. |
| AID1067044 | Antifungal activity against Candida glabrata by micro-broth dilution method | 2014 | European journal of medicinal chemistry, Mar-03, Volume: 74 | Synthesis, antifungal activities and molecular docking studies of novel 2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propyl dithiocarbamates. |
| AID1465972 | Antifungal activity against Candida albicans NR-29368 after 44 hrs by broth dilution assay | 2017 | Bioorganic & medicinal chemistry, 06-01, Volume: 25, Issue:11 | Investigation of aryl isonitrile compounds with potent, broad-spectrum antifungal activity. |
| AID545270 | Antifungal activity against Candida krusei E28 after 24 hrs by broth microdilution method | 2010 | European journal of medicinal chemistry, Dec, Volume: 45, Issue:12 | New amino acid esters of salicylanilides active against MDR-TB and other microbes. |
| AID1864893 | Antifungal activity against fluconazole -resistant Candida albicans 632 assessed as fungal growth inhibition measured after 72 hrs by double dilution method | |||
| AID365064 | Antifungal activity against Candida albicans D5 after 48 hrs by broth macrodilution method | 2008 | Bioorganic & medicinal chemistry, Sep-01, Volume: 16, Issue:17 | Antifungal activity of synthetic di(hetero)arylamines based on the benzo[b]thiophene moiety. |
| AID1272746 | Antifungal activity against Aspergillus niger at 0.25 mol/L after 2 to 4 days by paper disc method | 2016 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 26, Issue:3 | Synthesis, antimicrobial activity of Schiff base compounds of cinnamaldehyde and amino acids. |
| AID1740329 | Antifungal activity against Aspergillus flavus ATCC 9643 assessed as reduction in fungal growth incubated for 48 hrs by broth microdilution method | 2020 | European journal of medicinal chemistry, Sep-15, Volume: 202 | Design, synthesis and antimicrobial evaluation of novel glycosylated-fluoroquinolones derivatives. |
| AID323594 | Antifungal activity against Candida albicans bloodstream isolates by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5 | In vitro activities of isavuconazole and other antifungal agents against Candida bloodstream isolates. |
| AID1877291 | Antifungal activity against FLC-resistant Candida albicans 100 assessed as fungal growth inhibition by NCCLS protocol based method | 2022 | European journal of medicinal chemistry, Jan-05, Volume: 227 | Broadening antifungal spectrum and improving metabolic stablity based on a scaffold strategy: Design, synthesis, and evaluation of novel 4-phenyl-4,5-dihydrooxazole derivatives as potent fungistatic and fungicidal reagents. |
| AID1770949 | Antifungal activity against fluconazole-sensitive Candida albicans 311 assessed as fungal growth inhibition by CLSI protocol based method | 2021 | European journal of medicinal chemistry, Dec-05, Volume: 225 | Design, synthesis and evaluation of novel 5-phenylthiophene derivatives as potent fungicidal of Candida albicans and antifungal reagents of fluconazole-resistant fungi. |
| AID1864916 | Toxicity in mouse infected with Candida albicans assessed as lung injury at 10 ug per 20 g, ip administered on day 2, 4, 6, 8, 10 and 12 and measured on day 14 by H and E staining based assay | |||
| AID555586 | Antimicrobial activity against Saccharomyces cerevisiae by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Activity profile in vitro of micafungin against Spanish clinical isolates of common and emerging species of yeasts and molds. |
| AID680123 | TP_TRANSPORTER: transepithelial transport (basal to apical) in MDR1-expressing LLC-PK1 cells | 2002 | The Journal of pharmacology and experimental therapeutics, Oct, Volume: 303, Issue:1 | Interaction of cytochrome P450 3A inhibitors with P-glycoprotein. |
| AID1205745 | Antifungal activity against Cryptococcus gattii 196L/03 after 72 hrs by microdilution method | 2015 | ACS medicinal chemistry letters, Mar-12, Volume: 6, Issue:3 | Synthesis of a New Peptide-Coumarin Conjugate: A Potential Agent against Cryptococcosis. |
| AID1246659 | Antifungal activity against Cryptococcus gattii ATCC 32608 assessed as reduction in cell viability at 26 uM after 6 to 72 hrs by MTT assay | 2015 | European journal of medicinal chemistry, Sep-18, Volume: 102 | Thiazole compounds with activity against Cryptococcus gattii and Cryptococcus neoformans in vitro. |
| AID1391296 | Antifungal activity against fluconazole-resistant Cryptococcus neoformans serotype A MRL862 harboring erg11 mutant measured over 4 days | 2018 | Bioorganic & medicinal chemistry, 05-15, Volume: 26, Issue:9 | Synthesis and biological evaluation of aminothiazoles against Histoplasma capsulatum and Cryptococcus neoformans. |
| AID1472824 | Antifungal activity against Aspergillus nidulans ATCC 38163 after 48 hrs by broth dilution method | 2018 | Journal of medicinal chemistry, 01-11, Volume: 61, Issue:1 | Alkylated Piperazines and Piperazine-Azole Hybrids as Antifungal Agents. |
| AID1885981 | Antifungal activity against Cryptococcus gattii WM179 assessed as fungal growth inhibition incubated for 72 hrs in presence of P163-0892 by broth microdilution method | |||
| AID1762157 | Antifungal activity against Candida albicans 604M assessed as reduction in fungal growth incubated for 48 hrs by CLSI based serial microbroth dilution method | 2021 | Bioorganic & medicinal chemistry letters, 05-15, Volume: 40 | Synthesis and antifungal activity of new hybrids thiazolo[4,5-d]pyrimidines with (1H-1,2,4)triazole. |
| AID395838 | Antimicrobial activity against Trichophyton mentagrophytes after 96 hrs by standard microbroth dilution assay | 2009 | European journal of medicinal chemistry, Jan, Volume: 44, Issue:1 | Tetrahydronaphthyl azole oxime ethers: the conformationally rigid analogues of oxiconazole as antibacterials. |
| AID529545 | Antifungal activity against Candida glabrata 06-3169 harboring FSK1p T1896G and D632E mutant obtained from patient on compound therapy by M27-A2 method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Reduced Candida glabrata susceptibility secondary to an FKS1 mutation developed during candidemia treatment. |
| AID118052 | In vivo evaluation of % survival rate after peroral administration on 3rd day at dose 2.5 mg/kg | 1995 | Journal of medicinal chemistry, Sep-29, Volume: 38, Issue:20 | Synthesis and antifungal activity of new azole derivatives containing an N-acylmorpholine ring. |
| AID1759458 | Upregulation of Lac1 gene expression in Cryptococcus neoformans PFCC 93-589 at 4 ug/ml by SYBR green based RT-PCR analysis | 2021 | Bioorganic & medicinal chemistry letters, 06-01, Volume: 41 | Inhibitory effects and mechanism of antifungal action of the natural cyclic depsipeptide, aureobasidin A against Cryptococcus neoformans. |
| AID625283 | Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for elevated liver function tests | 2011 | PLoS computational biology, Dec, Volume: 7, Issue:12 | Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). |
| AID747350 | Antibacterial activity against Escherichia coli DH52 by NCCLS method | 2013 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 23, Issue:11 | Synthesis and biological evaluation of a class of quinolone triazoles as potential antimicrobial agents and their interactions with calf thymus DNA. |
| AID405059 | Antifungal activity against Sporothrix schenckii P14036 isolate from cutaneous-lymphatic sporotrichosis patient after 72 hrs by ATB Fungus 2 method | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | In vitro susceptibility of Sporothrix schenckii to six antifungal agents determined using three different methods. |
| AID1391608 | Antifungal activity against fluconazole-resistant Candida albicans 28A after 48 hrs by broth microdilution method | 2018 | Bioorganic & medicinal chemistry letters, 05-15, Volume: 28, Issue:9 | Diversity-oriented synthesis of pyrazoles derivatives from flavones and isoflavones leads to the discovery of promising reversal agents of fluconazole resistance in Candida albicans. |
| AID420667 | Antifungal activity against Aspergillus fumigatus by micro-broth dilution method | 2009 | European journal of medicinal chemistry, May, Volume: 44, Issue:5 | Design, synthesis, and biological evaluation of novel triazole derivatives as inhibitors of cytochrome P450 14alpha-demethylase. |
| AID665399 | Antifungal activity against Aspergillus fumigatus MTCC 2550 after 48 hrs by serial dilution technique | 2012 | European journal of medicinal chemistry, Jul, Volume: 53 | Synthesis, characterization, antimicrobial activities and QSAR studies of some 10a-phenylbenzo[b]indeno[1,2-e][1,4]thiazin-11(10aH)-ones. |
| AID1413327 | Antifungal activity against Candida lusitaniae 95-767 | 2018 | MedChemComm, Jun-01, Volume: 9, Issue:6 | Antifungal amphiphilic kanamycins: new life for an old drug. |
| AID1419514 | Toxicity in human A549 cells assessed as reduction in cell viability incubated for 24 hrs by resazurin dye based assay | 2017 | European journal of medicinal chemistry, Jun-16, Volume: 133 | Novel alkylated azoles as potent antifungals. |
| AID1556208 | Antifungal activity against Candida albicans CPCC 400523 assessed as inhibition of visible microbial growth by NCCLS protocol based method | 2019 | European journal of medicinal chemistry, Sep-01, Volume: 177 | Design, synthesis, and structure-activity relationship studies of l-amino alcohol derivatives as broad-spectrum antifungal agents. |
| AID424643 | Antimicrobial activity against azole-resistant Candida albicans isolate CA10 assessed as growth at 4 ug/ml cotreated with 0.125 ug/ml calcineurin signaling inhibitor Tacrolimus after 48 hrs by microdilution checkboard technique relative to control | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | In vitro interactions between tacrolimus and azoles against Candida albicans determined by different methods. |
| AID274097 | Effect of compound on Candida albicans sensitivity to Fluconazole: Minimum inhibitory concentration required to inhibit the growth of 50% of isolates after 24h. | 2007 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 17, Issue:5 | Discovery of uracil-based histone deacetylase inhibitors able to reduce acquired antifungal resistance and trailing growth in Candida albicans. |
| AID1154843 | Antifungal activity against fluconazole-sensitive Candida albicans SC5314 assessed as cell membrane damage at 8 ug/ml after 8 hrs by TEM analysis | 2014 | ACS medicinal chemistry letters, May-08, Volume: 5, Issue:5 | Novel carboline derivatives as potent antifungal lead compounds: design, synthesis, and biological evaluation. |
| AID1872497 | Antifungal activity against Aspergillus fumigatus | 2022 | European journal of medicinal chemistry, Mar-05, Volume: 231 | Synthetic approaches and structural diversity of triazolylbutanols derived from voriconazole in the antifungal drug development. |
| AID781087 | Antifungal activity against Geotrichum candidum MTCC-3993 after 24 to 72 hrs by broth dilution method | 2013 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 23, Issue:22 | Unusual transformation of substituted-3-formylchromones to pyrimidine analogues: synthesis and antimicrobial activities of 5-(o-hydroxyaroyl)pyrimidines. |
| AID276392 | Antifungal activity against Trichophyton mentagrophytes by broth microdilution technique | 2006 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 16, Issue:22 | Naphtho[2,3-b][1,4]-thiazine-5,10-diones and 3-substituted-1,4-dioxo-1,4-dihydronaphthalen-2-yl-thioalkanoate derivatives: synthesis and biological evaluation as potential antibacterial and antifungal agents. |
| AID527144 | Antifungal activity against Candida krusei LMGO 174 after 5 days microdilution technique | 2010 | Journal of natural products, Oct-22, Volume: 73, Issue:10 | Search for antifungal compounds from the wood of durable tropical trees. |
| AID546069 | Antifungal activity against Candida krusei isolated from candidemia patient by AFST-EUCAST microdilution method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | A 10-year survey of antifungal susceptibility of candidemia isolates from intensive care unit patients in Greece. |
| AID555013 | Antifungal activity against Candida membranifaciens assessed as percent susceptible isolates at 25 ug/disc by CLSI M44-A disk diffusion method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | In vitro activities of fluconazole and voriconazole against clinical isolates of Candida spp. determined by disk diffusion testing in Turin, Italy. |
| AID595004 | Ratio of MIC to MFC for Aspergillus fumigatus | 2011 | Bioorganic & medicinal chemistry letters, May-15, Volume: 21, Issue:10 | Thermal solvent-free synthesis of novel pyrazolyl chalcones and pyrazolines as potential antimicrobial agents. |
| AID1689226 | Antifungal activity against Aspergillus fumigatus NR 35303 assessed as reduction in fungal growth incubated for 24 hrs by CLSI based broth microdilution method | 2020 | European journal of medicinal chemistry, Mar-01, Volume: 189 | Oxadiazolylthiazoles as novel and selective antifungal agents. |
| AID595005 | Ratio of MIC to MFC for Trichophyton mentagrophytes | 2011 | Bioorganic & medicinal chemistry letters, May-15, Volume: 21, Issue:10 | Thermal solvent-free synthesis of novel pyrazolyl chalcones and pyrazolines as potential antimicrobial agents. |
| AID293593 | Antifungal activity against Candida albicans isolate assessed after 48 hrs by serial dilution method | 2007 | Bioorganic & medicinal chemistry, Mar-01, Volume: 15, Issue:5 | Synthesis and biological evaluation of new N-(2-hydroxy-4(or 5)-nitro/aminophenyl)benzamides and phenylacetamides as antimicrobial agents. |
| AID1556542 | Antifungal activity against Aspergillus fumigatus assessed as reduction in fungal cell viability incubated for 24 hrs by two fold serial dilution method | 2019 | European journal of medicinal chemistry, Oct-01, Volume: 179 | A new exploration towards aminothiazolquinolone oximes as potentially multi-targeting antibacterial agents: Design, synthesis and evaluation acting on microbes, DNA, HSA and topoisomerase IV. |
| AID1658340 | Antifungal activity against fluconazole-resistant Candida albicans 17# assessed as reduction in fungal growth by NCCLS method | 2020 | ACS medicinal chemistry letters, Jun-11, Volume: 11, Issue:6 | Construction and Evaluation of Molecular Models: Guide and Design of Novel SE Inhibitors. |
| AID245919 | Cytotoxicity to reduce chronic myeloid leukemia K 562 cells | 2004 | Journal of medicinal chemistry, Jul-29, Volume: 47, Issue:16 | Imidazole analogues of fluoxetine, a novel class of anti-Candida agents. |
| AID1556229 | Inhibition of CYP51 in Candida albicans ATCC SC5314 assessed as eburicol level at 2 ug/ml incubated for 16 hrs by GC/MS analysis (Rvb = 0%) | 2019 | European journal of medicinal chemistry, Sep-01, Volume: 177 | Design, synthesis, and structure-activity relationship studies of l-amino alcohol derivatives as broad-spectrum antifungal agents. |
| AID516269 | Antimicrobial activity against Cryptococcus gattii serotype B isolate NIH771 assessed as concentration required for heteroresistance | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Heteroresistance of Cryptococcus gattii to fluconazole. |
| AID554720 | Antimicrobial activity against Saccharomyces cerevisiae isolate AD overexpressing Candida krusei ERG11C after 48 hrs by liquid microdilution assay | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Abc1p is a multidrug efflux transporter that tips the balance in favor of innate azole resistance in Candida krusei. |
| AID1279023 | Antifungal activity against Candida tropicalis 156 after 24 hrs by microbroth dilution method | 2016 | Bioorganic & medicinal chemistry, Mar-15, Volume: 24, Issue:6 | Salicylanilide N-monosubstituted carbamates: Synthesis and in vitro antimicrobial activity. |
| AID1759433 | Antifungal activity against Cryptococcus neoformans PFCC 93-589 after 2 days in absence of sorbitol by microdilution assay | 2021 | Bioorganic & medicinal chemistry letters, 06-01, Volume: 41 | Inhibitory effects and mechanism of antifungal action of the natural cyclic depsipeptide, aureobasidin A against Cryptococcus neoformans. |
| AID405198 | Antimicrobial activity against Blastoschizomyces capitatus IHEM 16105 isolate infected OF1 mouse blastoschizomycosis model assessed as spleen microbial count per gram of tissue at 80 mg/kg/day, po for 6 days administered 1 hr before microbial challenge | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | Combined therapies in a murine model of blastoschizomycosis. |
| AID1411850 | Antifungal activity against fluconazole resistant Candida albicans 167-1 by CLSI protocol based broth microdilution method | 2017 | MedChemComm, Dec-01, Volume: 8, Issue:12 | Synergistic antifungal effect of cyclized chalcone derivatives and fluconazole against |
| AID1624187 | Antifungal activity against Cryptococcus neoformans NR-41296 after 24 hrs by microbroth dilution method | 2019 | Bioorganic & medicinal chemistry letters, 03-01, Volume: 29, Issue:5 | Benzimidazole tethered pyrrolo[3,4-b]quinoline with broad-spectrum activity against fungal pathogens. |
| AID518874 | Antimicrobial activity against Cryptococcus gattii serotype C isolate NIH191 assessed as heteroresistant isolates at 16 ug/ml | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Heteroresistance of Cryptococcus gattii to fluconazole. |
| AID622966 | Antifungal activity against Candida krusei ATCC 6258 after 48 hrs by microdilution method | 2011 | Bioorganic & medicinal chemistry letters, Oct-15, Volume: 21, Issue:20 | Synthesis and biological activity of desmethoxy analogues of coruscanone A. |
| AID276388 | Antifungal activity against Candida parapsilosis ATCC 22019 by broth microdilution technique | 2006 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 16, Issue:22 | Naphtho[2,3-b][1,4]-thiazine-5,10-diones and 3-substituted-1,4-dioxo-1,4-dihydronaphthalen-2-yl-thioalkanoate derivatives: synthesis and biological evaluation as potential antibacterial and antifungal agents. |
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| AID48960 | Tested in vitro for the minimum inhibitory concentration (MIC) against Candida albicans ATCC 64550 | 2002 | Bioorganic & medicinal chemistry letters, Mar-11, Volume: 12, Issue:5 | Synthesis of Sordaricin analogues as potent antifungal agents against Candida albicans. |
| AID588215 | FDA HLAED, alkaline phosphatase increase | 2004 | Current drug discovery technologies, Dec, Volume: 1, Issue:4 | Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling. |
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| AID406953 | Cytotoxicity against human U937 cells assessed as reduction of cell viability after 24 hrs by MTT assay | 2008 | Journal of medicinal chemistry, Jul-10, Volume: 51, Issue:13 | 1-[(3-Aryloxy-3-aryl)propyl]-1H-imidazoles, new imidazoles with potent activity against Candida albicans and dermatophytes. Synthesis, structure-activity relationship, and molecular modeling studies. |
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| AID563606 | Effect on sterol composition in Candida albicans isolate 108 harboring erg11 and erg5 double mutant assessed as zymosterol level after 2 hrs by gas chromatography | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | A clinical isolate of Candida albicans with mutations in ERG11 (encoding sterol 14alpha-demethylase) and ERG5 (encoding C22 desaturase) is cross resistant to azoles and amphotericin B. |
| AID1864887 | Antifungal activity against Candida krusei ATCC 6258 assessed as fungal growth inhibition measured after 72 hrs in presence of naproxen by double dilution method | |||
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| AID1770934 | Anti-biofilm activity in Candida albicans CPCC400616 assessed as inhibition of biofilm formation incubated for 18 hrs by XTT assay | 2021 | European journal of medicinal chemistry, Dec-05, Volume: 225 | Design, synthesis and evaluation of novel 5-phenylthiophene derivatives as potent fungicidal of Candida albicans and antifungal reagents of fluconazole-resistant fungi. |
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| AID537670 | Antifungal activity against Candida tropicalis ATCC 13803 after 18 hrs by agar-well diffusion method | 2010 | European journal of medicinal chemistry, Nov, Volume: 45, Issue:11 | Cyclization of some carbothioamide derivatives containing antipyrine and triazole moieties and investigation of their antimicrobial activities. |
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| AID521517 | Antifungal activity against Pseudallescheria boydii NBRC 32229 after 72 hrs by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | In vitro and in vivo antifungal activities of T-2307, a novel arylamidine. |
| AID626342 | Antifungal activity against Chrysosporium keratinophilum MTCC 2827 at 1 mg/mL after 72 hrs by by agar-well diffusion method | 2011 | European journal of medicinal chemistry, Nov, Volume: 46, Issue:11 | Hantzsch reaction: synthesis and characterization of some new 1,4-dihydropyridine derivatives as potent antimicrobial and antioxidant agents. |
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| AID623055 | Antifungal activity against Absidia corymbifera 272 after 48 hrs by microdilution method | 2011 | Bioorganic & medicinal chemistry letters, Oct-15, Volume: 21, Issue:20 | Synthesis and biological activity of desmethoxy analogues of coruscanone A. |
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| AID1905294 | Reversal of fluconazole mediated azole resistant Candida albicans 904 assessed as upregulation of CDR2 expression at 32 ug/ml by RT-PCR | 2022 | Journal of medicinal chemistry, 04-14, Volume: 65, Issue:7 | Species-Selective Targeting of Fungal Hsp90: Design, Synthesis, and Evaluation of Novel 4,5-Diarylisoxazole Derivatives for the Combination Treatment of Azole-Resistant Candidiasis. |
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| AID340959 | Antifungal activity against Candida parapsilosis ATCC 22013 by NCCLS M27-A2 method | 2007 | Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8 | Cross-resistance to medical and agricultural azole drugs in yeasts from the oropharynx of human immunodeficiency virus patients and from environmental Bavarian vine grapes. |
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| AID1601663 | Antibiofilm activity against Candida albicans PMC 1042 assessed as inhibition of mature biofilm formation by XTT reduction assay | |||
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| AID1491246 | Antifungal activity against fluconazole-resistant Candida albicans strain 100 by broth microdilution method | 2017 | European journal of medicinal chemistry, Sep-08, Volume: 137 | Design, synthesis and evaluation of aromatic heterocyclic derivatives as potent antifungal agents. |
| AID1279034 | Antifungal activity against Trichophyton mentagrophytes 445 after 120 hrs by microbroth dilution method | 2016 | Bioorganic & medicinal chemistry, Mar-15, Volume: 24, Issue:6 | Salicylanilide N-monosubstituted carbamates: Synthesis and in vitro antimicrobial activity. |
| AID623051 | Antifungal activity against Trichosporon asahii 1188 after 48 hrs by microdilution method | 2011 | Bioorganic & medicinal chemistry letters, Oct-15, Volume: 21, Issue:20 | Synthesis and biological activity of desmethoxy analogues of coruscanone A. |
| AID1427201 | Antifungal activity against Candida albicans ATCC 44859 after 48 hrs by microdilution broth assay | 2017 | Bioorganic & medicinal chemistry, 03-15, Volume: 25, Issue:6 | Antimicrobial activity of rhodanine-3-acetic acid derivatives. |
| AID1430406 | Antifungal activity against Candida albicans ATCC 10231 after 24 to 48 hrs by macro-broth dilution method | 2017 | Bioorganic & medicinal chemistry letters, 03-01, Volume: 27, Issue:5 | Methylsulfonyl benzothiazoles (MSBT) derivatives: Search for new potential antimicrobial and anticancer agents. |
| AID1759459 | Downregulation of Cxt1p gene expression in Cryptococcus neoformans PFCC 93-589 at 4 ug/ml by SYBR green based RT-PCR analysis | 2021 | Bioorganic & medicinal chemistry letters, 06-01, Volume: 41 | Inhibitory effects and mechanism of antifungal action of the natural cyclic depsipeptide, aureobasidin A against Cryptococcus neoformans. |
| AID1193506 | Antifungal activity against Candida glabrata IFRC 339 after 24 to 168 hrs by broth microdilution assay | 2015 | Bioorganic & medicinal chemistry, Apr-01, Volume: 23, Issue:7 | Synthesis and biological evaluation of fluconazole analogs with triazole-modified scaffold as potent antifungal agents. |
| AID519284 | Antifungal activity against Candida parapsilosis ATCC 22019 by AFST-EUCAST method | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | Reliability of the WIDERYST susceptibility testing system for detection of in vitro antifungal resistance in yeasts. |
| AID1304743 | Antifungal activity against Trichophyton verrucosum measured after 7 days by serial dilution method | 2016 | Journal of medicinal chemistry, Apr-14, Volume: 59, Issue:7 | Discovery of Potent Benzofuran-Derived Diapophytoene Desaturase (CrtN) Inhibitors with Enhanced Oral Bioavailability for the Treatment of Methicillin-Resistant Staphylococcus aureus (MRSA) Infections. |
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| AID518649 | Antimicrobial activity against Cryptococcus gattii serotype C isolate H0058-1-1941 assessed as heteroresistant isolates at 4 ug/ml | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Heteroresistance of Cryptococcus gattii to fluconazole. |
| AID525406 | Antifungal activity against Candida glabrata isolate 4370 after 48 hrs by microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Posaconazole against Candida glabrata isolates with various susceptibilities to fluconazole. |
| AID1419538 | Hemolytic activity in mouse erythrocytes assessed as hemolysis level at 125 ug/ml incubated for 1 hr at 37 degC | 2017 | European journal of medicinal chemistry, Jun-16, Volume: 133 | Novel alkylated azoles as potent antifungals. |
| AID407061 | Inhibition of metabolic activity in Candida albicans SC5314 at 32 ug/ml in presence of 2 ug/ml calcineurin pathway inhibitor FK506 | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | Role for cell density in antifungal drug resistance in Candida albicans biofilms. |
| AID1369483 | Antifungal activity against Candida albicans cgmcc 2.2086 in presence of FeCl3 by broth dilution method | 2018 | Journal of medicinal chemistry, 05-10, Volume: 61, Issue:9 | Combating Drug-Resistant Fungi with Novel Imperfectly Amphipathic Palindromic Peptides. |
| AID1380516 | Antifungal activity against Candida albicans Gu4 assessed as inhibition of fungal growth incubated for 48 hrs by broth microdilution assay | 2018 | Bioorganic & medicinal chemistry letters, 06-01, Volume: 28, Issue:10 | Biofilm inhibition and anti-Candida activity of a cationic lipo-benzamide molecule with twin-nonyl chain. |
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| AID1877292 | Antifungal activity against FLC-resistant Candida albicans 103 assessed as fungal growth inhibition by NCCLS protocol based method | 2022 | European journal of medicinal chemistry, Jan-05, Volume: 227 | Broadening antifungal spectrum and improving metabolic stablity based on a scaffold strategy: Design, synthesis, and evaluation of novel 4-phenyl-4,5-dihydrooxazole derivatives as potent fungistatic and fungicidal reagents. |
| AID1271237 | Antifungal activity against Cryptococcus neoformans ATCC 34664 after 24 to 36 hrs by broth microdilution method | 2015 | ACS medicinal chemistry letters, Nov-12, Volume: 6, Issue:11 | Silicon Incorporated Morpholine Antifungals: Design, Synthesis, and Biological Evaluation. |
| AID1762172 | Antifungal activity against Candida glabrata 61L assessed as reduction in fungal growth incubated for 24 hrs by CLSI based serial microbroth dilution method | 2021 | Bioorganic & medicinal chemistry letters, 05-15, Volume: 40 | Synthesis and antifungal activity of new hybrids thiazolo[4,5-d]pyrimidines with (1H-1,2,4)triazole. |
| AID283229 | Effect on Coccidioides immitis Silveira infection in CD1 mouse brain, spinal cord and lungs administered after 3 days of infection at 50 mg/kg, po bid after 10 days | 2007 | Antimicrobial agents and chemotherapy, Mar, Volume: 51, Issue:3 | Comparison of itraconazole and fluconazole treatments in a murine model of coccidioidal meningitis. |
| AID540210 | Clearance in human after iv administration | 2008 | Drug metabolism and disposition: the biological fate of chemicals, Jul, Volume: 36, Issue:7 | Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. |
| AID1918384 | Anti-inflammatory activity in mouse infected with Candida albicans assessed as reduction in COX-2 expression in infection tissues at 20 mg/kg, ip administered on days 2,4,6,8,10,12 and measured on day 14 by western blot analysis | 2022 | Journal of medicinal chemistry, 11-10, Volume: 65, Issue:21 | Novel Aryl Alkamidazole Derivatives as Multifunctional Antifungal Inhibitors: Design, Synthesis, and Biological Evaluation. |
| AID554715 | Antimicrobial activity against Candida krusei NZCDC 89.221 after 48 hrs by CLSI method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Abc1p is a multidrug efflux transporter that tips the balance in favor of innate azole resistance in Candida krusei. |
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| AID535686 | Antibacterial activity against Cryptococcus neoformans serotype A after 72 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Antifungal susceptibilities among different serotypes of Cryptococcus gattii and Cryptococcus neoformans. |
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| AID584373 | Ratio of URA3 gene expression in Candida glabrata isolated from patient 002 receiving antifungal drug to URA3 gene expression in Candida glabrata isolated from patient 002 by RT-PCR analysis | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Impact of antifungal prophylaxis on colonization and azole susceptibility of Candida species. |
| AID1370735 | Antifungal activity against Candida albicans Y0109 after 24 hrs by serial dilution method | 2018 | Bioorganic & medicinal chemistry letters, 02-01, Volume: 28, Issue:3 | Design, synthesis, and structure-activity relationship studies of novel tetrazole antifungal agents with potent activity, broad antifungal spectrum and high selectivity. |
| AID310270 | Antimicrobial activity against Saccharomyces cerevisiae ADCDR1 by serial dilution microplate method | 2007 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 17, Issue:23 | Rational design of N-alkyl derivatives of 2-amino-2-deoxy-d-glucitol-6P as antifungal agents. |
| AID518679 | Antimicrobial activity against Cryptococcus gattii serotype C isolate H0058-1-1941 assessed as heteroresistant isolates at 8 ug/ml | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Heteroresistance of Cryptococcus gattii to fluconazole. |
| AID575747 | Binding affinity to Aspergillus fumigatus AF293 sterol 14-alpha demethylase isoenzyme A expressed in Escherichia coli | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10 | Expression, purification, and characterization of Aspergillus fumigatus sterol 14-alpha demethylase (CYP51) isoenzymes A and B. |
| AID1740167 | Antifungal activity against Candida albicans ATCC 90028 measured after 24 hrs by resazurin dye based assay | 2020 | European journal of medicinal chemistry, Sep-01, Volume: 201 | Synthesis, antibacterial and antifungal activity of new 3-biphenyl-3H-Imidazo[1,2-a]azepin-1-ium bromides. |
| AID574599 | Antifungal activity against Candida albicans ATCC 44859 after 24 hrs by broth microdilution method | 2011 | Bioorganic & medicinal chemistry, Feb-15, Volume: 19, Issue:4 | Synthesis and antimycobacterial properties of N-substituted 6-amino-5-cyanopyrazine-2-carboxamides. |
| AID625835 | Antifungal activity against Candida parapsilosis by broth microdilution method | 2011 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 21, Issue:21 | Micelles catalyzed chemoselective synthesis 'in water' and biological evaluation of oxygen containing hetero-1,4-naphthoquinones as potential antifungal agents. |
| AID358879 | Antifungal activity against MDR knockout Candida albicans DSY1024 after 24 hrs by XTT assay | 2001 | Journal of natural products, Mar, Volume: 64, Issue:3 | Three new phenolic compounds from a manipulated plant cell culture, Mirabilis jalapa. |
| AID407005 | Antimicrobial activity against Candida albicans FH1 dissociated biofilms at cell density of 10'3 cells/ml after 48 hrs by XTT assay | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | Role for cell density in antifungal drug resistance in Candida albicans biofilms. |
| AID582247 | Antifungal activity against Candida krusei isolated from HSCT recipients with acute or chronic GVHD prior to initiation of fluconazole therapy assessed as maximum MIC by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Impact of antifungal prophylaxis on colonization and azole susceptibility of Candida species. |
| AID444052 | Hepatic clearance in human | 2010 | Journal of medicinal chemistry, Feb-11, Volume: 53, Issue:3 | Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. |
| AID432098 | Antifungal activity against Aspergillus niger at 10 ug/ml for 48 hrs by disc diffusion method | 2009 | European journal of medicinal chemistry, Sep, Volume: 44, Issue:9 | Synthesis, spectral characterization, in-vitro microbiological evaluation and cytotoxic activities of novel macrocyclic bis hydrazone. |
| AID519046 | Antifungal activity against Candida glabrata after 48 hrs by broth microdilution | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | Antimicrobial activity of omiganan pentahydrochloride against contemporary fungal pathogens responsible for catheter-associated infections. |
| AID519281 | Antifungal activity against Candida krusei ATCC 6258 by AFST-EUCAST method | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | Reliability of the WIDERYST susceptibility testing system for detection of in vitro antifungal resistance in yeasts. |
| AID1413328 | Antifungal activity against Candida rugosa 95-967 | 2018 | MedChemComm, Jun-01, Volume: 9, Issue:6 | Antifungal amphiphilic kanamycins: new life for an old drug. |
| AID293416 | Antifungal activity against Aspergillus fumigatus NCIM 902 by serial plate dilution method | 2007 | European journal of medicinal chemistry, May, Volume: 42, Issue:5 | Synthesis of some new bioactive 3-amino-2-mercapto-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-4(3H)-one derivatives. |
| AID1061244 | Antimicrobial activity against Aspergillus flavus at 0.5 mg/ml by well plate method | 2014 | European journal of medicinal chemistry, Jan, Volume: 71 | Synthesis and biological evaluation of novel substituted 1,3,4-thiadiazole and 2,6-di aryl substituted imidazo [2,1-b] [1,3,4] thiadiazole derivatives. |
| AID542097 | Antifungal activity against Aspergillus terreus ATCC 28301 after 24 hrs by microdilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Discovery of a small-molecule inhibitor of {beta}-1,6-glucan synthesis. |
| AID1585624 | Antifungal activity against Candida albicans SC5314 cultured in RPMI 1640 media after 24 hrs by broth microdilution method | 2019 | European journal of medicinal chemistry, Jan-15, Volume: 162 | Chemical preparation, biological evaluation and 3D-QSAR of ethoxysulfuron derivatives as novel antifungal agents targeting acetohydroxyacid synthase. |
| AID518133 | Antimicrobial activity against Cryptococcus gattii serotype B isolate RB-14 assessed as concentration required for heteroresistance | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Heteroresistance of Cryptococcus gattii to fluconazole. |
| AID719312 | Antimicrobial activity against Escherichia coli NCIM 2574 by broth dilution method | 2012 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 22, Issue:23 | Synthesis, characterization, antidepressant and antioxidant activity of novel piperamides bearing piperidine and piperazine analogues. |
| AID405062 | Antifungal activity against Sporothrix schenckii P30915 isolate from cutaneous-lymphatic sporotrichosis patient after 72 hrs by ATB Fungus 2 method | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | In vitro susceptibility of Sporothrix schenckii to six antifungal agents determined using three different methods. |
| AID582777 | Antifungal activity against Candida albicans isolate 1008 harboring ERG3 K97E, L193P, V237A, A351V, A353T and ERG11 E266D mutant genes assessed as 14alpha-methyl fecosterol content in total sterol composition at 0.5 times MIC by GC-MS analysis | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | Identification and characterization of four azole-resistant erg3 mutants of Candida albicans. |
| AID1890273 | Antifungal activity against Microsporum canis clinical isolate 3 assessed as reduction in fungal growth by broth dilution method | 2022 | Bioorganic & medicinal chemistry letters, 05-01, Volume: 63 | Novel 2-aryl-4-aryloxyquinoline-based fungistatics for Mucor circinelloides. Biological evaluation of activity, QSAR and docking study. |
| AID1352428 | Antifungal activity against drug-resistant Candida tropicalis by CLSI two fold serial dilution method | 2018 | European journal of medicinal chemistry, Feb-25, Volume: 146 | Discovery of 2-aminothiazolyl berberine derivatives as effectively antibacterial agents toward clinically drug-resistant Gram-negative Acinetobacter baumanii. |
| AID1877287 | Antifungal activity against FLC-resistant Candida albicans CaR assessed as fungal growth inhibition by NCCLS protocol based method | 2022 | European journal of medicinal chemistry, Jan-05, Volume: 227 | Broadening antifungal spectrum and improving metabolic stablity based on a scaffold strategy: Design, synthesis, and evaluation of novel 4-phenyl-4,5-dihydrooxazole derivatives as potent fungistatic and fungicidal reagents. |
| AID1898153 | Antifungal activity against Candida albicans Y0109 | |||
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| AID1175554 | Antimicrobial activity against Candida parapsilosis ATCC 22019 after 18 hrs | 2015 | Journal of natural products, Jan-23, Volume: 78, Issue:1 | Antibacterial ilicicolinic acids C and D and ilicicolinal from Neonectria discophora SNB-CN63 isolated from a termite nest. |
| AID424642 | Antimicrobial activity against azole-resistant Candida albicans isolate CA10 assessed as growth at 2 ug/ml cotreated with 0.125 ug/ml calcineurin signaling inhibitor tacrolimus after 48 hrs by microdilution checkerboard technique relative to control | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | In vitro interactions between tacrolimus and azoles against Candida albicans determined by different methods. |
| AID1877862 | Antibiofilm activity against Candida albicans at 1 ug/mL by microscopic analysis | 2022 | Bioorganic & medicinal chemistry letters, 02-15, Volume: 58 | Synthesis and antifungal evaluation of phenol-derived bis(indolyl)methanes combined with FLC against Candida albicans. |
| AID307402 | Antifungal activity against Aspergillus terreus ATCC 28301by broth microdilution assay | 2007 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 17, Issue:12 | Discovery of novel indazole-linked triazoles as antifungal agents. |
| AID1484683 | Leishmanicidal activity against Leishmania major KK promastigote forms after 18 hrs by indirect microscopic analysis | 2017 | European journal of medicinal chemistry, Jul-28, Volume: 135 | An overview of azoles targeting sterol 14α-demethylase for antileishmanial therapy. |
| AID582787 | Antifungal activity against Candida albicans isolate 12 harboring ERG3 W332R mutant gene assessed as lanosterol/obtusifoliol content in total sterol composition at 0.5 times MIC by GC-MS analysis | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | Identification and characterization of four azole-resistant erg3 mutants of Candida albicans. |
| AID1885994 | Antifungal activity against Cryptococcus neoformans clinical isolate HN19 assessed as fungal growth inhibition incubated for 72 hrs in presence of P163-0892 by broth microdilution method | |||
| AID323597 | Antifungal activity against Candida parapsilosis bloodstream isolates by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5 | In vitro activities of isavuconazole and other antifungal agents against Candida bloodstream isolates. |
| AID48793 | In vitro evaluation of minimum inhibitory concentration against Candida tropicalis 2.11 | 1995 | Journal of medicinal chemistry, Sep-29, Volume: 38, Issue:20 | Synthesis and antifungal activity of new azole derivatives containing an N-acylmorpholine ring. |
| AID582216 | Antifungal activity against Candida albicans isolated from HSCT recipients with acute or chronic GVHD prior to initiation of posaconazole therapy by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Impact of antifungal prophylaxis on colonization and azole susceptibility of Candida species. |
| AID509277 | Permeability across BBMEC cocultured with rat C6 cell BBB model after 24 hrs in presence of 0.1 ug/ml interleukin-2 | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Effects of immunomodulatory and organism-associated molecules on the permeability of an in vitro blood-brain barrier model to amphotericin B and fluconazole. |
| AID1271244 | Antifungal activity against Aspergillus niger ATCC 10578 after 72 hrs by broth microdilution method | 2015 | ACS medicinal chemistry letters, Nov-12, Volume: 6, Issue:11 | Silicon Incorporated Morpholine Antifungals: Design, Synthesis, and Biological Evaluation. |
| AID1904252 | Inhibition of biofilm formation in Cryptococcus neoformans H99 at 8 ug/ml incubated for 24 hrs by XTT reduction assay | 2022 | Journal of medicinal chemistry, 05-12, Volume: 65, Issue:9 | Discovery of Novel Sertraline Derivatives as Potent Anti- |
| AID362709 | Antifungal activity against Aspergillus fumigatus ATCC 10894 | 2008 | Journal of natural products, Sep, Volume: 71, Issue:9 | Bioactive asterric acid derivatives from the Antarctic ascomycete fungus Geomyces sp. |
| AID1728522 | Inhibition of Candida albicans ATCC SC5314 CYP51 incubated for 30 mins by spectrophotometric method | 2021 | European journal of medicinal chemistry, Jan-15, Volume: 210 | Novel naphthylamide derivatives as dual-target antifungal inhibitors: Design, synthesis and biological evaluation. |
| AID1060930 | Antimicrobial activity against Aspergillus flavus after 24 hrs by two-fold serial dilution method | 2014 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 24, Issue:1 | 1,2,3-Triazole-derived naphthalimides as a novel type of potential antimicrobial agents: synthesis, antimicrobial activity, interaction with calf thymus DNA and human serum albumin. |
| AID1918361 | Inhibition of CYP51 in Candida albicans ATCC SC5314 assessed as lanosterol content at 4 ug/ml measured after 48 hrs by GC-MS analysis | 2022 | Journal of medicinal chemistry, 11-10, Volume: 65, Issue:21 | Novel Aryl Alkamidazole Derivatives as Multifunctional Antifungal Inhibitors: Design, Synthesis, and Biological Evaluation. |
| AID685144 | Antifungal activity against Candida albicans MTCC 227 after 48 hrs by tube dilution method | 2012 | European journal of medicinal chemistry, Oct, Volume: 56 | Synthesis, antimicrobial and cytotoxicity study of 1,3-disubstituted-1H-naphtho[1,2-e][1,3]oxazines. |
| AID527136 | Antifungal activity against Trichophyton rubrum LMGO 06 after 5 days microdilution technique | 2010 | Journal of natural products, Oct-22, Volume: 73, Issue:10 | Search for antifungal compounds from the wood of durable tropical trees. |
| AID372234 | Effect on MDR1 RNA level in Candida albicans CHK21 at MIC after 120 mins by RT-PCR | 2007 | Antimicrobial agents and chemotherapy, Oct, Volume: 51, Issue:10 | The Ssk1p response regulator and Chk1p histidine kinase mutants of Candida albicans are hypersensitive to fluconazole and voriconazole. |
| AID425124 | Antimicrobial activity against azole-resistant Candida albicans isolate CA10 assessed as growth at 0.5 ug/ml cotreated with 0.002 ug/ml calcineurin signaling inhibitor tacrolimus after 48 hrs by microdilution checkerboard technique relative to control | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | In vitro interactions between tacrolimus and azoles against Candida albicans determined by different methods. |
| AID1413329 | Antifungal activity against Candida tropicalis 95-41 | 2018 | MedChemComm, Jun-01, Volume: 9, Issue:6 | Antifungal amphiphilic kanamycins: new life for an old drug. |
| AID1890288 | Cytotoxicity against mouse NIH/3T3 cells assessed as reduction in cell viability at 50 ug/ml incubated for 48 hrs by MTT assay (Rvb = 93.8 +/- 4.9 %) | 2022 | Bioorganic & medicinal chemistry letters, 05-01, Volume: 63 | Novel 2-aryl-4-aryloxyquinoline-based fungistatics for Mucor circinelloides. Biological evaluation of activity, QSAR and docking study. |
| AID751627 | Antifungal activity against Candida albicans up to 24 hrs | 2013 | European journal of medicinal chemistry, Feb, Volume: 60 | Synthesis and antifungal activity of some s-mercaptotriazolobenzothiazolyl amino acid derivatives. |
| AID143888 | Inhibitory activity against Candida albicans N-Myristoyltransferase (CaNmt) assessed as inhibitory concentration using substrate peptide and myristotyl-CoA at 0.5 uM; Not tested | 2002 | Bioorganic & medicinal chemistry letters, Feb-25, Volume: 12, Issue:4 | Design and synthesis of novel benzofurans as a new class of antifungal agents targeting fungal N-myristoyltransferase. Part 2. |
| AID48819 | Tested in vitro for the minimum inhibitory concentration (MIC) against Candida tropicalis ATCC750 | 2002 | Bioorganic & medicinal chemistry letters, Mar-11, Volume: 12, Issue:5 | Synthesis of Sordaricin analogues as potent antifungal agents against Candida albicans. |
| AID719446 | Antifungal activity against Candida albicans MTCC 3017 at 1000 ug/mL after 72 hrs by well plate method | 2012 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 22, Issue:24 | Synthesis, antioxidant and antimicrobial activity of novel vanillin derived piperidin-4-one oxime esters: preponderant role of the phenyl ester substituents on the piperidin-4-one oxime core. |
| AID766641 | Antifungal activity against Candida aaseri MTCC 1962 after 24 hrs by well diffusion method | 2013 | European journal of medicinal chemistry, Sep, Volume: 67 | Total synthesis and biological evaluation of clavaminol-G and its analogs. |
| AID1326658 | Antifungal activity against Candida utilis measured after 24 hrs by two-fold serial dilution method | 2016 | European journal of medicinal chemistry, Oct-21, Volume: 122 | Design, synthesis and biological evaluation of berberine-benzimidazole hybrids as new type of potentially DNA-targeting antimicrobial agents. |
| AID1465974 | Antifungal activity against Candida albicans ATCC MYA 573 after 44 hrs by broth dilution assay | 2017 | Bioorganic & medicinal chemistry, 06-01, Volume: 25, Issue:11 | Investigation of aryl isonitrile compounds with potent, broad-spectrum antifungal activity. |
| AID425146 | Antimicrobial activity against azole-resistant Candida albicans isolate CA10 assessed as growth at 64 ug/ml after 48 hrs by microdilution checkerboard technique relative to control | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | In vitro interactions between tacrolimus and azoles against Candida albicans determined by different methods. |
| AID545669 | Drug uptake in human PMNC assessed as increase in intracellular compound concentration by radiometric assay relative to control | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | Intracellular concentrations of posaconazole in different compartments of peripheral blood. |
| AID1168324 | Binding affinity to human serum albumin assessed as formation of non-fluorescent compound-protein complex at 298 K at pH 7.4 by fluorescence quenching method | 2014 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 24, Issue:21 | Study the interactions between human serum albumin and two antifungal drugs: fluconazole and its analogue DTP. |
| AID1487219 | Inhibition of CYP2C9 in human hepatocyte microsomes using diclofenac substrate by HPLC/MS/MS method | 2017 | Bioorganic & medicinal chemistry letters, 08-01, Volume: 27, Issue:15 | Design and optimization of highly-selective, broad spectrum fungal CYP51 inhibitors. |
| AID1549154 | Inhibition of CYP51 in azole-resistant Candida albicans 0304103 assessed as ergosterol content at 0.5 ug/ml after 24 hrs by GC-MS analysis (Rvb = 75.21%) | 2020 | Journal of medicinal chemistry, 05-28, Volume: 63, Issue:10 | Discovery of Novel Fungal Lanosterol 14α-Demethylase (CYP51)/Histone Deacetylase Dual Inhibitors to Treat Azole-Resistant Candidiasis. |
| AID1563959 | Antifungal activity against Cryptococcus neoformans ATCC 32719 assessed as reduction in fungal cell growth incubated for 48 hrs by two-fold serial dilution method | 2019 | European journal of medicinal chemistry, Oct-15, Volume: 180 | Design, synthesis and biological evaluation of novel 5-(piperazin-1-yl)quinolin-2(1H)-one derivatives as potential chitin synthase inhibitors and antifungal agents. |
| AID625290 | Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for liver fatty | 2011 | PLoS computational biology, Dec, Volume: 7, Issue:12 | Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). |
| AID1295327 | Antifungal activity against Sporothrix schenckii after 48 hrs by broth microdilution method | 2016 | European journal of medicinal chemistry, Jun-10, Volume: 115 | Role of disulfide linkage in action of bis(dialkylaminethiocarbonyl)disulfides as potent double-Edged microbicidal spermicide: Design, synthesis and biology. |
| AID1328363 | Antifungal activity against Cryptococcus neoformans ATCC 90113 assessed as growth inhibition measured after 72 hrs by CLSI method | 2016 | Journal of natural products, 09-23, Volume: 79, Issue:9 | Synthesis of Natural Acylphloroglucinol-Based Antifungal Compounds against Cryptococcus Species. |
| AID1179904 | Antimicrobial activity against Candida mycoderma by two-fold serial dilution technique | 2014 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 24, Issue:15 | Synthesis and bioactive evaluation of a novel series of coumarinazoles. |
| AID1689222 | Antifungal activity against Cryptococcus neoformans NR41300 assessed as reduction in fungal growth incubated for 48 hrs by CLSI based broth microdilution method | 2020 | European journal of medicinal chemistry, Mar-01, Volume: 189 | Oxadiazolylthiazoles as novel and selective antifungal agents. |
| AID762704 | Antimicrobial activity against Aspergillus niger MTCC 281 | 2013 | Bioorganic & medicinal chemistry letters, Aug-15, Volume: 23, Issue:16 | Novel pyrazoline amidoxime and their 1,2,4-oxadiazole analogues: synthesis and pharmacological screening. |
| AID407002 | Antimicrobial activity against Candida albicans GDH2346 intact biofilms after 48 hrs by XTT assay | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | Role for cell density in antifungal drug resistance in Candida albicans biofilms. |
| AID567439 | Antifungal activity against Trichosporon jirovecii after 48 hrs by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | In vitro antifungal activities of isavuconazole and comparators against rare yeast pathogens. |
| AID1719182 | Antifungal activity against fluconazole-sensitive Candida albicans F2 assessed as reduction in microbial growth | 2021 | Bioorganic & medicinal chemistry letters, 03-01, Volume: 35 | A new 1-nitro-9-aminoacridine derivative targeting yeast topoisomerase II able to overcome fluconazole-resistance. |
| AID532953 | Antifungal activity against Candida albicans isolate V3 with CAI genotype by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | Correlation between azole susceptibilities, genotypes, and ERG11 mutations in Candida albicans isolates associated with vulvovaginal candidiasis in China. |
| AID118054 | In vivo evaluation of % survival rate after peroral administration on 3rd day at dose 5 mg/kg | 1995 | Journal of medicinal chemistry, Sep-29, Volume: 38, Issue:20 | Synthesis and antifungal activity of new azole derivatives containing an N-acylmorpholine ring. |
| AID549032 | Antimicrobial activity against Candida krusei LMR 39-14 infected in immunosuppressed CF-1 mouse assessed as increased survival of mouse at 40 mg/kg, ip administered once daily for 5 days relative to control | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Activity of anidulafungin in a murine model of Candida krusei infection: evaluation of mortality and disease burden by quantitative tissue cultures and measurement of serum (1,3)-beta-D-glucan levels. |
| AID405099 | Antimicrobial activity against Rhizomucor sp. after 24 hrs | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | In vitro susceptibilities of 217 clinical isolates of zygomycetes to conventional and new antifungal agents. |
| AID691706 | Antifungal activity against Aspergillus niger MTCC 1344 after 24 hrs by serial dilution method | 2012 | Bioorganic & medicinal chemistry letters, Oct-15, Volume: 22, Issue:20 | Synthesis of β-ionone derived chalcones as potent antimicrobial agents. |
| AID1369503 | Binding affinity to phosphatidylcholine/cholesterol large unilamellar vesicle assessed as induction of calcein leakage at 2 to 32 uM after 15 mins by spectrofluorophotometric method | 2018 | Journal of medicinal chemistry, 05-10, Volume: 61, Issue:9 | Combating Drug-Resistant Fungi with Novel Imperfectly Amphipathic Palindromic Peptides. |
| AID1904356 | Antifungal activity against Candida albicans ATCC SC5314 assessed as fungal growth inhibition by CLSI based serial microbroth dilution method | 2022 | European journal of medicinal chemistry, Apr-05, Volume: 233 | Design, synthesis, and evaluation of novel 3-thiophene derivatives as potent fungistatic and fungicidal reagents based on a conformational restriction strategy. |
| AID1054558 | Antifungal activity against Candida parapsilosis ATCC 22019 after 48 hrs by broth microdilution technique | 2013 | European journal of medicinal chemistry, , Volume: 70 | Azole-carbodithioate hybrids as vaginal anti-Candida contraceptive agents: design, synthesis and docking studies. |
| AID424889 | Antimicrobial activity against azole-resistant Candida albicans isolate CA10 assessed as growth at 0.25 ug/ml cotreated with 0.016 ug/ml calcineurin signaling inhibitor Tacrolimus after 48 hrs by microdilution checkboard technique relative to control | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | In vitro interactions between tacrolimus and azoles against Candida albicans determined by different methods. |
| AID564269 | Antifungal activity against Candida albicans isolate 6 after 48 hrs by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | A clinical isolate of Candida albicans with mutations in ERG11 (encoding sterol 14alpha-demethylase) and ERG5 (encoding C22 desaturase) is cross resistant to azoles and amphotericin B. |
| AID279113 | Ratio of AUC in surviving candidemia patient to MIC at 48 hrs against Candida species | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Association of fluconazole area under the concentration-time curve/MIC and dose/MIC ratios with mortality in nonneutropenic patients with candidemia. |
| AID613455 | Antifungal activity against Yarrowia lipolytica isolate NCL4 after 24 hrs by broth dilution method | 2011 | European journal of medicinal chemistry, Sep, Volume: 46, Issue:9 | Stereoselective synthesis and antimicrobial activity of steroidal C-20 tertiary alcohols with thiazole/pyridine side chain. |
| AID1472820 | Antifungal activity against Candida glabrata ATCC 2001 after 48 hrs by broth dilution method | 2018 | Journal of medicinal chemistry, 01-11, Volume: 61, Issue:1 | Alkylated Piperazines and Piperazine-Azole Hybrids as Antifungal Agents. |
| AID584398 | Antifungal activity against 14 days cultured Candida krusei isolated from neutropenic subject with AML or MDS stool after 12 days of prophylaxis by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Impact of antifungal prophylaxis on colonization and azole susceptibility of Candida species. |
| AID48931 | Tested for in vitro antifungal activity against Candida albicans ATCC 64550 | 2002 | Bioorganic & medicinal chemistry letters, Jul-08, Volume: 12, Issue:13 | Synthesis and evaluation of N-substituted 1,4-oxazepanyl Sordaricins as selective fungal EF-2 inhibitors. |
| AID1592221 | Antifungal activity against Candida albicans assessed as inhibition of microbial growth at 25 to 250 nM/mL by polarizing microscopy | 2019 | Bioorganic & medicinal chemistry, 06-15, Volume: 27, Issue:12 | Design, synthesis and biological evaluation of amide-pyridine derivatives as novel dual-target (SE, CYP51) antifungal inhibitors. |
| AID1674375 | Oral bioavailability in human | 2020 | Journal of medicinal chemistry, 11-12, Volume: 63, Issue:21 | Integrating the Impact of Lipophilicity on Potency and Pharmacokinetic Parameters Enables the Use of Diverse Chemical Space during Small Molecule Drug Optimization. |
| AID567427 | Antifungal activity against Dipodascus capitatus after 3 days by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | In vitro antifungal activities of isavuconazole and comparators against rare yeast pathogens. |
| AID1597998 | Antifungal activity against Cryptococcus neoformans after 72 hrs by NCCLS protocol based method | 2019 | European journal of medicinal chemistry, May-15, Volume: 170 | Current advances of triazole alcohols derived from fluconazole: Design, in vitro and in silico studies. |
| AID602929 | Antifungal activity against Candida parapsilosis by micro-broth dilution method | 2011 | European journal of medicinal chemistry, Jul, Volume: 46, Issue:7 | Design, synthesis and antifungal evaluation of 1-(2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propyl)-1H-1,2,4-triazol-5(4H)-one. |
| AID1487215 | Inhibition of CYP3A4 in human hepatocyte microsomes using testosterone substrate by HPLC/MS/MS method | 2017 | Bioorganic & medicinal chemistry letters, 08-01, Volume: 27, Issue:15 | Design and optimization of highly-selective, broad spectrum fungal CYP51 inhibitors. |
| AID750173 | Antifungal activity against Trichophyton rubrum by NCCLS method | 2013 | European journal of medicinal chemistry, Jun, Volume: 64 | Discovery of highly potent triazole antifungal derivatives by heterocycle-benzene bioisosteric replacement. |
| AID521514 | Antifungal activity against Aspergillus niger NBRC 33023 after 48 hrs by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | In vitro and in vivo antifungal activities of T-2307, a novel arylamidine. |
| AID1904387 | Antibiofilm activity against Candida albicans CPCC40061 assessed as inhibition of bacterial metabolism within the biofilm measured after 18 hrs by XTT reduction assay | 2022 | European journal of medicinal chemistry, Apr-05, Volume: 233 | Design, synthesis, and evaluation of novel 3-thiophene derivatives as potent fungistatic and fungicidal reagents based on a conformational restriction strategy. |
| AID493526 | Antifungal activity against Trichophyton mentagrophytes 445 after 120 hrs by broth microdilution assay | 2010 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 20, Issue:15 | N-Benzylsalicylthioamides as novel compounds with promising antimycotic activity. |
| AID519514 | Antifungal activity against Candida sp. isolates after 48 hrs by CLSI M27-A2 procedure based assay | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | In vitro antifungal activities of isavuconazole (BAL4815), voriconazole, and fluconazole against 1,007 isolates of zygomycete, Candida, Aspergillus, Fusarium, and Scedosporium species. |
| AID725879 | Antifungal activity against acquired-resistant Candida parapsilosis CAPA1 after 24 hrs by spectrofluorometric analysis | 2013 | ACS medicinal chemistry letters, Feb-14, Volume: 4, Issue:2 | Discovery of a novel broad-spectrum antifungal agent derived from albaconazole. |
| AID301291 | Antifungal activity against Candida albicans ATCC 60193 after 48 hrs by broth micro dilution technique | 2007 | Bioorganic & medicinal chemistry, Nov-01, Volume: 15, Issue:21 | Synthesis of disulfide esters of dialkylaminocarbothioic acid as potent, non-detergent spermicidal agents. |
| AID581889 | Antifungal activity against Candida albicans isolated from HSCT recipient 031 with acute or chronic GVHD mouth receiving antifungal drug after 109 days prophylaxis by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Impact of antifungal prophylaxis on colonization and azole susceptibility of Candida species. |
| AID1595124 | Antifungal activity against Aspergillus fumigatus assessed as reduction in fungal cell growth incubated for 48 hrs by broth microdilution method | 2019 | European journal of medicinal chemistry, May-15, Volume: 170 | Tetrazole hybrids and their antifungal activities. |
| AID1738741 | Inhibition of CYP51 in azole-resistant Candida albicans ATCC SC531 assessed as Lanosterol level at 2 ug/ml incubated for 16 hrs by LC-MS analysis relative to control | 2020 | European journal of medicinal chemistry, Jul-15, Volume: 198 | Design, synthesis, and biological evaluation of novel miconazole analogues containing selenium as potent antifungal agents. |
| AID1624185 | Antifungal activity against Cryptococcus neoformans NR-41291 after 24 hrs by microbroth dilution method | 2019 | Bioorganic & medicinal chemistry letters, 03-01, Volume: 29, Issue:5 | Benzimidazole tethered pyrrolo[3,4-b]quinoline with broad-spectrum activity against fungal pathogens. |
| AID392421 | Antifungal activity against Candida albicans CA98001 | 2009 | Bioorganic & medicinal chemistry letters, Jan-15, Volume: 19, Issue:2 | Synthesis and structure-activity relationships of 2-phenyl-1-[(pyridinyl- and piperidinylmethyl)amino]-3-(1H-1,2,4-triazol-1-yl)propan-2-ols as antifungal agents. |
| AID584401 | Antifungal activity against 60 days cultured Candida glabrata isolated from HSCT recipient with acute or chronic GVHD mouth receiving antifungal therapy for 75 days after 33 days of prophylaxis by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Impact of antifungal prophylaxis on colonization and azole susceptibility of Candida species. |
| AID582803 | Antifungal activity against Candida albicans isolate 6 by broth microdilution method in presence of 10 uM drug efflux inhibitor FK506 | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | Identification and characterization of four azole-resistant erg3 mutants of Candida albicans. |
| AID1271239 | Antifungal activity against Candida glabrata NCYC 388 after 24 to 36 hrs by broth microdilution method | 2015 | ACS medicinal chemistry letters, Nov-12, Volume: 6, Issue:11 | Silicon Incorporated Morpholine Antifungals: Design, Synthesis, and Biological Evaluation. |
| AID623054 | Antifungal activity against Absidia corymbifera 272 after 24 hrs by microdilution method | 2011 | Bioorganic & medicinal chemistry letters, Oct-15, Volume: 21, Issue:20 | Synthesis and biological activity of desmethoxy analogues of coruscanone A. |
| AID644843 | Antifungal activity against Candida glabrata PMC 0805 after 48 hrs by M27-A3 CLSI method | 2012 | European journal of medicinal chemistry, Mar, Volume: 49 | Synthesis and antifungal activity of a new series of 2-(1H-imidazol-1-yl)-1-phenylethanol derivatives. |
| AID678583 | Antifungal activity against Candida albicans Berkout KCCM 50235 after 1 day by twofold broth dilution method | 2012 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 22, Issue:18 | Synthesis and antifungal activity of 1-thia-4b-aza-cyclopenta[b]fluorene-4,10-diones. |
| AID1758029 | Inhibition of CYP51 in Candida albicans ATCC SC5314 assessed as ergosterol level at 2 ug/ml after 16 hrs by GC-MS analysis (Rvb = 98.3%) | 2021 | European journal of medicinal chemistry, Apr-15, Volume: 216 | Lead optimization generates selenium-containing miconazole CYP51 inhibitors with improved pharmacological profile for the treatment of fungal infections. |
| AID1157295 | Antifungal activity against Aspergillus fumigatus 07544 assessed as growth inhibition by automatic microplate reader analysis | 2014 | Journal of natural products, May-23, Volume: 77, Issue:5 | Polyhydroxy cyclohexanols from a Dendrodochium sp. fungus associated with the sea cucumber Holothuria nobilis Selenka. |
| AID1767307 | Antifungal activity against Candida tropicalis assessed as fungal growth inhibition by CLSI protocol based microbroth dilution method | 2021 | European journal of medicinal chemistry, Oct-05, Volume: 221 | Discovery of novel purinylthiazolylethanone derivatives as anti-Candida albicans agents through possible multifaceted mechanisms. |
| AID1877298 | Inhibition of CYP51 in Candida albicans SC3514 assessed as decrease in ergosterol biosynthesis by measuring eburicol level at 0.25 ug/ml incubated for 16 hrs by GC-MS analysis relative to total sterols | 2022 | European journal of medicinal chemistry, Jan-05, Volume: 227 | Broadening antifungal spectrum and improving metabolic stablity based on a scaffold strategy: Design, synthesis, and evaluation of novel 4-phenyl-4,5-dihydrooxazole derivatives as potent fungistatic and fungicidal reagents. |
| AID411180 | Ratio of MFC to MIC against Candida glabrata DSM6425 | 2009 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 19, Issue:1 | One-pot synthesis of 5-phenylimino, 5-thieno or 5-oxo-1,2,3-dithiazoles and evaluation of their antimicrobial and antitumor activity. |
| AID424917 | Antimicrobial activity against azole-resistant Candida albicans isolate CA10 assessed as growth at 16 ug/ml co-treated with 0.004 ug/ml calcineurin signaling inhibitor tacrolimus after 48 hrs by microdilution checkboard technique relative to control | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | In vitro interactions between tacrolimus and azoles against Candida albicans determined by different methods. |
| AID467285 | Antifungal activity against Candida albicans by serial dilution method after 24 hrs | 2009 | Bioorganic & medicinal chemistry letters, Oct-15, Volume: 19, Issue:20 | Discovery of highly potent novel antifungal azoles by structure-based rational design. |
| AID1157178 | Antifungal activity against Microsporum gypseum PMC 7331 after 72 hrs by CLSI broth microdilution method | 2014 | European journal of medicinal chemistry, Aug-18, Volume: 83 | Synthesis, biological evaluation and structure-activity correlation study of a series of imidazol-based compounds as Candida albicans inhibitors. |
| AID1767317 | Antifungal activity against Candida albicans measured after 8 passages | 2021 | European journal of medicinal chemistry, Oct-05, Volume: 221 | Discovery of novel purinylthiazolylethanone derivatives as anti-Candida albicans agents through possible multifaceted mechanisms. |
| AID319752 | Antimicrobial activity against Candida tropicalis isolates | 2008 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 18, Issue:11 | Synthesis and SAR studies of biaryloxy-substituted triazoles as antifungal agents. |
| AID555016 | Antifungal activity against Candida albicans by reference dilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | In vitro activities of fluconazole and voriconazole against clinical isolates of Candida spp. determined by disk diffusion testing in Turin, Italy. |
| AID294853 | Antifungal activity against Trichophyton rubrum after 7 days by microbroth dilution method | 2007 | European journal of medicinal chemistry, Sep, Volume: 42, Issue:9 | Synthesis of novel triazole derivatives as inhibitors of cytochrome P450 14alpha-demethylase (CYP51). |
| AID340951 | Antifungal activity against Candida albicans isolates from animals by NCCLS M27-A2 method | 2007 | Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8 | Cross-resistance to medical and agricultural azole drugs in yeasts from the oropharynx of human immunodeficiency virus patients and from environmental Bavarian vine grapes. |
| AID584418 | Antifungal activity against 62 days cultured Candida glabrata isolated from HSCT recipient with acute or chronic GVHD mouth receiving antifungal therapy for 143 days after 116 days of prophylaxis by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Impact of antifungal prophylaxis on colonization and azole susceptibility of Candida species. |
| AID1556221 | Inhibition of CYP51 in Candida albicans ATCC SC5314 assessed as obtusifoliol level at 2 ug/ml incubated for 16 hrs by GC/MS analysis (Rvb = 0%) | 2019 | European journal of medicinal chemistry, Sep-01, Volume: 177 | Design, synthesis, and structure-activity relationship studies of l-amino alcohol derivatives as broad-spectrum antifungal agents. |
| AID510307 | Antimicrobial activity against flucytosine, azole, and caspofungin resistant Candida glabrata bloodstream isolate 1 serially obtained from hematopoietic stem cell transplant recipient by Etest | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Acquisition of flucytosine, azole, and caspofungin resistance in Candida glabrata bloodstream isolates serially obtained from a hematopoietic stem cell transplant recipient. |
| AID545329 | Antimicrobial activity against Candida albicans isolate R after 24 hrs by microdilution method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Breakthrough Aspergillus fumigatus and Candida albicans double infection during caspofungin treatment: laboratory characteristics and implication for susceptibility testing. |
| AID1759447 | Hemolytic activity in human RBC at 16 ug/ml incubated for 30 mins | 2021 | Bioorganic & medicinal chemistry letters, 06-01, Volume: 41 | Inhibitory effects and mechanism of antifungal action of the natural cyclic depsipeptide, aureobasidin A against Cryptococcus neoformans. |
| AID274919 | Antifungal activity against Cryptococcus neoformans ATCC 90113 | 2006 | Journal of medicinal chemistry, Dec-28, Volume: 49, Issue:26 | Synthesis, antifungal activity, and structure-activity relationships of coruscanone A analogues. |
| AID1138330 | Antimicrobial activity against Cryptococcus neoformans 32609 after 72 hrs by serial dilution method | 2014 | Journal of medicinal chemistry, May-08, Volume: 57, Issue:9 | Design, synthesis, and structure-activity relationship studies of novel fused heterocycles-linked triazoles with good activity and water solubility. |
| AID1783081 | Downregulation of CAP59 gene expression in Cryptococcus neoformans H99 at 2 ug/ml measured after 24 hrs by qRT-PCR analysis | 2021 | European journal of medicinal chemistry, Oct-05, Volume: 221 | Lanosterol 14α-demethylase (CYP51)/histone deacetylase (HDAC) dual inhibitors for treatment of Candida tropicalis and Cryptococcus neoformans infections. |
| AID566885 | Antifungal activity against Aspergillus niger by microdilution test | 2011 | European journal of medicinal chemistry, Jan, Volume: 46, Issue:1 | Synthesis and antifungal activity of some substituted phenothiazines and related compounds. |
| AID424895 | Antimicrobial activity against azole-resistant Candida albicans isolate CA10 assessed as growth at 16 ug/ml co-treated with 0.016 ug/ml calcineurin signaling inhibitor tacrolimus after 48 hrs by microdilution checkboard technique relative to control | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | In vitro interactions between tacrolimus and azoles against Candida albicans determined by different methods. |
| AID681143 | TP_TRANSPORTER: increase in Calcein-AM intracellular accumulation in MDR1-expressing LLC-PK1 cells | 2002 | Molecular pharmacology, May, Volume: 61, Issue:5 | Three-dimensional quantitative structure-activity relationships of inhibitors of P-glycoprotein. |
| AID1890286 | Antifungal activity against Mucor circinelloides R7B wild type strain assessed as reduction in fungal growth by broth dilution method | 2022 | Bioorganic & medicinal chemistry letters, 05-01, Volume: 63 | Novel 2-aryl-4-aryloxyquinoline-based fungistatics for Mucor circinelloides. Biological evaluation of activity, QSAR and docking study. |
| AID490332 | Antimicrobial activity against Pseudomonas aeruginosa ATCC 278533 after 24 hrs by microdilution assay | 2010 | European journal of medicinal chemistry, Jul, Volume: 45, Issue:7 | Synthesis and biological evaluation of some thio containing pyrrolo [2,3-d]pyrimidine derivatives for their anti-inflammatory and anti-microbial activities. |
| AID307396 | Antifungal activity against Cryptococcus neoformans ATCC 21019 by broth microdilution assay | 2007 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 17, Issue:12 | Discovery of novel indazole-linked triazoles as antifungal agents. |
| AID32670 | In vitro inhibition of Absidia corymbifera 272 growth for 48 hours. | 2001 | Journal of medicinal chemistry, Aug-16, Volume: 44, Issue:17 | 3-Phenyl-5-acyloxymethyl-2H,5H-furan-2-ones: synthesis and biological activity of a novel group of potential antifungal drugs. |
| AID599923 | Antifungal activity against Candida albicans after 96 hrs | 2011 | European journal of medicinal chemistry, Jun, Volume: 46, Issue:6 | Amberlite-IRA-402 (OH) ion exchange resin mediated synthesis of indolizines, pyrrolo [1,2-a] quinolines and isoquinolines: antibacterial and antifungal evaluation of the products. |
| AID279107 | Mortality rate stratified by 48 hrs MIC in susceptible Candida species infected patient | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Association of fluconazole area under the concentration-time curve/MIC and dose/MIC ratios with mortality in nonneutropenic patients with candidemia. |
| AID1330189 | Antibacterial activity against Escherichia coli 1924 measured after 24 hrs by two-fold serial dilution method | 2016 | Bioorganic & medicinal chemistry letters, 12-15, Volume: 26, Issue:24 | Synthesis and biological evaluation of chalcone derivatives containing aminoguanidine or acylhydrazone moieties. |
| AID1689830 | Inhibition of sterol biosynthesis in Candida albicans CAAL93 assessed as zymosterol level at 10 ng/ml after 18 hrs by GC-MS analysis (Rvb = 1.6%) | 2020 | European journal of medicinal chemistry, Mar-01, Volume: 189 | New azole antifungals with a fused triazinone scaffold. |
| AID1419548 | Selectivity index, ratio of EC50 for toxicity in human BEAS2B cells to MIC50 for antifungal activity against ITC and FLC-susceptible Candida albicans ATCC MYA-2310 | 2017 | European journal of medicinal chemistry, Jun-16, Volume: 133 | Novel alkylated azoles as potent antifungals. |
| AID1634151 | Partition coefficient, log P of the compound | 2019 | Bioorganic & medicinal chemistry letters, 08-15, Volume: 29, Issue:16 | Strategies for the development of highly selective cytochrome P450 inhibitors: Several CYP targets in current research. |
| AID1491255 | Inhibition of CYP51 in Candida albicans ATCC SC5314 assessed as ergosterol content at 8 ug/ml by GS-MS analysis relative to total sterols (Rvb = 98.7%) | 2017 | European journal of medicinal chemistry, Sep-08, Volume: 137 | Design, synthesis and evaluation of aromatic heterocyclic derivatives as potent antifungal agents. |
| AID1193512 | Cytotoxicity against human HepG2 cells after 2 days by MTT assay | 2015 | Bioorganic & medicinal chemistry, Apr-01, Volume: 23, Issue:7 | Synthesis and biological evaluation of fluconazole analogs with triazole-modified scaffold as potent antifungal agents. |
| AID670403 | Antifungal activity against Candida albicans MTCC 3017 by well diffusion method | 2012 | Bioorganic & medicinal chemistry letters, Jul-15, Volume: 22, Issue:14 | Synthesis, biological evaluation of 5-carbomethoxymethyl-7-hydroxy-2-pentylchromone, 5-carboethoxymethyl-4',7-dihydroxyflavone and their analogues. |
| AID678586 | Antifungal activity against Cryptococcus neoformans KCCM 50564 after 1 day by twofold broth dilution method | 2012 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 22, Issue:18 | Synthesis and antifungal activity of 1-thia-4b-aza-cyclopenta[b]fluorene-4,10-diones. |
| AID1484708 | Antileishmanial activity against Leishmania major infected in human assessed as healing of lesions at 200 mg/day, po administered for 6 weeks (Rvb = 34%) | 2017 | European journal of medicinal chemistry, Jul-28, Volume: 135 | An overview of azoles targeting sterol 14α-demethylase for antileishmanial therapy. |
| AID1864920 | Toxicity in mouse infected with Candida albicans assessed as AST level in plasma at 10 ug per 20 g, ip administered on day 2, 4, 6, 8, 10 and 12 and measured on day 14 (Rvb = 74.9 +/- 6.7 IU/L) | |||
| AID1287610 | Antifungal activity against Candida tropicalis ATCC 750 after 18 to 24 hrs by micro-dilution method | 2016 | European journal of medicinal chemistry, May-04, Volume: 113 | Synthesis of newer 1,2,3-triazole linked chalcone and flavone hybrid compounds and evaluation of their antimicrobial and cytotoxic activities. |
| AID547607 | Antifungal activity against Candida glabrata isolate Cg12R with CgPDR1 G348A mutant | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | Microarray and molecular analyses of the azole resistance mechanism in Candida glabrata oropharyngeal isolates. |
| AID1157149 | Antifungal activity against Candida albicans ATCC 10231 after 48 hrs by CLSI broth microdilution method | 2014 | European journal of medicinal chemistry, Aug-18, Volume: 83 | Synthesis, biological evaluation and structure-activity correlation study of a series of imidazol-based compounds as Candida albicans inhibitors. |
| AID1600160 | Antifungal activity against azole-resistant Candida tropicalis assessed as reduction in fungal growth incubated for 48 hrs by broth microdilution method | 2019 | European journal of medicinal chemistry, Oct-01, Volume: 179 | Discovery of new azoles with potent activity against Candida spp. and Candida albicans biofilms through virtual screening. |
| AID118057 | In vivo evaluation of % survival rate after peroral administration on 5th day at dose 1 mg/kg | 1995 | Journal of medicinal chemistry, Sep-29, Volume: 38, Issue:20 | Synthesis and antifungal activity of new azole derivatives containing an N-acylmorpholine ring. |
| AID424916 | Antimicrobial activity against azole-resistant Candida albicans isolate CA10 assessed as growth at 8 ug/ml co-treated with 0.004 ug/ml calcineurin signaling inhibitor tacrolimus after 48 hrs by microdilution checkboard technique relative to control | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | In vitro interactions between tacrolimus and azoles against Candida albicans determined by different methods. |
| AID520858 | Antifungal activity against Cryptococcus neoformans YC-11 infected in BALB/c mouse brain assessed as reduction in multiple fungal induced abscesses at 80 mg/kg, iv qd for 5 days measured after 7 days of infection by histopathological analysis | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | Efficacy of SPK-843, a novel polyene antifungal, in a murine model of systemic cryptococcosis. |
| AID382540 | Antifungal activity against Rhodothece glutinis SYM 2209 after 48 hrs standard broth microdilution method | 2008 | European journal of medicinal chemistry, Jan, Volume: 43, Issue:1 | Synthesis, structure and biological activity of pseudopeptidic macrolides based on an amino alcohol. |
| AID1598013 | Antifungal activity against Cryptococcus neoformans | 2019 | European journal of medicinal chemistry, May-15, Volume: 170 | Current advances of triazole alcohols derived from fluconazole: Design, in vitro and in silico studies. |
| AID1418530 | Antifungal activity against fluconazole-resistant Candida albicans 103 after 2 to 7 days by broth microdilution method | 2018 | Bioorganic & medicinal chemistry letters, 12-01, Volume: 28, Issue:22 | Design, synthesis, and biological evaluation of 4-chloro-2H-thiochromenes featuring nitrogen-containing side chains as potent antifungal agents. |
| AID1493864 | Antibiofilm activity against Candida albicans assessed inhibition of biofilm formation at 1024 ug/ml | 2018 | European journal of medicinal chemistry, Jan-01, Volume: 143 | Discovery of simplified sampangine derivatives as novel fungal biofilm inhibitors. |
| AID1597999 | Antifungal activity against Trichophyton rubrum after 7 days by NCCLS protocol based method | 2019 | European journal of medicinal chemistry, May-15, Volume: 170 | Current advances of triazole alcohols derived from fluconazole: Design, in vitro and in silico studies. |
| AID521983 | Antibacterial activity against Fluconazole resistant Candida albicans DSY3606 containing tac1delta/delta ERG11-1/ERG11-1 (TAC1-5) genotype infected in BALB/c mouse assessed as reduction in kidney microbial burden administered intraperitoneally 1 hr post b | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Genetic dissection of azole resistance mechanisms in Candida albicans and their validation in a mouse model of disseminated infection. |
| AID751630 | Antifungal activity against Aspergillus flavus by agar diffusion technique | 2013 | European journal of medicinal chemistry, Feb, Volume: 60 | Synthesis and antifungal activity of some s-mercaptotriazolobenzothiazolyl amino acid derivatives. |
| AID1707484 | Antifungal activity against Candida albicans 9172 incubated for 48 hrs by microdilution assay | 2021 | Journal of medicinal chemistry, 01-28, Volume: 64, Issue:2 | Novel Carboline Fungal Histone Deacetylase (HDAC) Inhibitors for Combinational Treatment of Azole-Resistant Candidiasis. |
| AID519050 | Antifungal activity against Aspergillus sp. after 48 hrs by broth microdilution | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | Antimicrobial activity of omiganan pentahydrochloride against contemporary fungal pathogens responsible for catheter-associated infections. |
| AID1411851 | Antifungal activity against fluconazole susceptible Candida albicans 002B1 by CLSI protocol based broth microdilution method | 2017 | MedChemComm, Dec-01, Volume: 8, Issue:12 | Synergistic antifungal effect of cyclized chalcone derivatives and fluconazole against |
| AID1546114 | Antifungal activity against Candida albicans | 2019 | European journal of medicinal chemistry, Dec-15, Volume: 184 | Current scenario of tetrazole hybrids for antibacterial activity. |
| AID352620 | Antimicrobial activity against Candida albicans ATCC 10145 by tube dilution method | 2009 | European journal of medicinal chemistry, Mar, Volume: 44, Issue:3 | Synthesis and in vitro antimicrobial activity of some novel substituted benzimidazole derivatives having potent activity against MRSA. |
| AID1738742 | Inhibition of CYP51 in azole-resistant Candida albicans ATCC SC531 assessed as Lanosterol level at 8 ug/ml incubated for 16 hrs by LC-MS analysis relative to control | 2020 | European journal of medicinal chemistry, Jul-15, Volume: 198 | Design, synthesis, and biological evaluation of novel miconazole analogues containing selenium as potent antifungal agents. |
| AID1224549 | Antifungal activity against Candida krusei E28 after 24 hrs by broth microdilution method | 2014 | European journal of medicinal chemistry, Jul-23, Volume: 82 | 1-Substituted-5-[(3,5-dinitrobenzyl)sulfanyl]-1H-tetrazoles and their isosteric analogs: A new class of selective antitubercular agents active against drug-susceptible and multidrug-resistant mycobacteria. |
| AID1491248 | Inhibition of CYP51 in Candida albicans ATCC SC5314 assessed as decrease in ergosterol content by GS-MS analysis | 2017 | European journal of medicinal chemistry, Sep-08, Volume: 137 | Design, synthesis and evaluation of aromatic heterocyclic derivatives as potent antifungal agents. |
| AID372255 | Fungicidal activity against Candida albicans CHK21 assessed as reduction in cell viability at MIC after 24 hrs | 2007 | Antimicrobial agents and chemotherapy, Oct, Volume: 51, Issue:10 | The Ssk1p response regulator and Chk1p histidine kinase mutants of Candida albicans are hypersensitive to fluconazole and voriconazole. |
| AID1918368 | Antifungal activity against Candida albicans infected in mouse assessed as reduction in total amount of fungal cells in infection region at 20 mg/kg, ip administered on days 2,4,6,8,10,12 and measured on day 14 by GMS staining based analysis | 2022 | Journal of medicinal chemistry, 11-10, Volume: 65, Issue:21 | Novel Aryl Alkamidazole Derivatives as Multifunctional Antifungal Inhibitors: Design, Synthesis, and Biological Evaluation. |
| AID581870 | Antifungal activity against Candida glabrata isolated from neutropenic subject 1318 with AML or MDS stool after 36 days prophylaxis by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Impact of antifungal prophylaxis on colonization and azole susceptibility of Candida species. |
| AID143926 | In vitro inhibitory activity against Aspergillus fumigatus Nmt (AfNmt) using substrate peptide GLTISKLFR-R-NH2 (0.5 uM) and myristoyl-CoA (0.5 uM); Not tested | 2003 | Bioorganic & medicinal chemistry letters, Jan-06, Volume: 13, Issue:1 | Design and synthesis of novel benzofurans as a new class of antifungal agents targeting fungal N-myristoyltransferase. Part 3. |
| AID1885985 | Antifungal activity against Candida krusei ATCC2340 assessed as fungal growth inhibition incubated for 48 hrs in presence of P163-0892 by broth microdilution method | |||
| AID518653 | Antimicrobial activity against Cryptococcus gattii serotype B isolate B3939 assessed as heteroresistant isolates at 8 ug/ml | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Heteroresistance of Cryptococcus gattii to fluconazole. |
| AID1904254 | Antifungal activity against Candida auris 0030 assessed as inhibition of fungal growth incubated for 48 hrs by microdilution method | 2022 | Journal of medicinal chemistry, 05-12, Volume: 65, Issue:9 | Discovery of Novel Sertraline Derivatives as Potent Anti- |
| AID581899 | Antifungal activity against Candida glabrata isolated from HSCT recipient 002 with acute or chronic GVHD mouth receiving antifungal drug after 116 days prophylaxis by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Impact of antifungal prophylaxis on colonization and azole susceptibility of Candida species. |
| AID1246587 | Antifungal activity against Cryptococcus neoformans ATCC 28957 after 48 to 72 hrs by broth microdilution method | 2015 | European journal of medicinal chemistry, Sep-18, Volume: 102 | Thiazole compounds with activity against Cryptococcus gattii and Cryptococcus neoformans in vitro. |
| AID1494191 | Antifungal activity against Cryptococcus neoformans isolate CN1 measured after 48 hrs by CLSI M27-A3 protocol based method | 2018 | Bioorganic & medicinal chemistry, 02-01, Volume: 26, Issue:3 | Novel fluconazole derivatives with promising antifungal activity. |
| AID1494177 | Antifungal activity against fluconazole/ITC-susceptible Candida albicans ATCC MYA-2310 measured after 48 hrs by CLSI M27-A3 protocol based method | 2018 | Bioorganic & medicinal chemistry, 02-01, Volume: 26, Issue:3 | Novel fluconazole derivatives with promising antifungal activity. |
| AID371234 | Antimicrobial activity against Cryptococcus neoformans TIMM 1855 by broth microdilution method | 2008 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 18, Issue:24 | Carbon analogs of antifungal dioxane-triazole derivatives: synthesis and in vitro activities. |
| AID323071 | Antifungal activity against Cryptococcus neoformans IM 00319 by microbroth dilution method | 2008 | Bioorganic & medicinal chemistry, Jan-15, Volume: 16, Issue:2 | Antifungal and cytotoxic activities of some N-substituted aniline derivatives bearing a hetaryl fragment. |
| AID518140 | Antimicrobial activity against Cryptococcus gattii serotype B isolate RB-34 assessed as concentration required for heteroresistance | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Heteroresistance of Cryptococcus gattii to fluconazole. |
| AID1481571 | Antifungal activity against Saccharomyces cerevisiae after 24 hrs by two-fold serial dilution assay | 2017 | Bioorganic & medicinal chemistry letters, 04-15, Volume: 27, Issue:8 | Novel benzimidazolyl tetrahydroprotoberberines: Design, synthesis, antimicrobial evaluation and multi-targeting exploration. |
| AID685145 | Antifungal activity against Aspergillus niger MTCC 8184 after 7 days by tube dilution method | 2012 | European journal of medicinal chemistry, Oct, Volume: 56 | Synthesis, antimicrobial and cytotoxicity study of 1,3-disubstituted-1H-naphtho[1,2-e][1,3]oxazines. |
| AID287831 | Antifungal activity against Absidia corymbifera 272 after 24 hrs | 2007 | Bioorganic & medicinal chemistry, Apr-15, Volume: 15, Issue:8 | Hybrid molecules of estrone: new compounds with potential antibacterial, antifungal, and antiproliferative activities. |
| AID704467 | Antifungal activity against fluconazole-resistant Candida albicans MY 2301 after 24 hrs by NCCLS broth microdilution method | 2012 | ACS medicinal chemistry letters, Oct-11, Volume: 3, Issue:10 | Antifungal spectrum, in vivo efficacy, and structure-activity relationship of ilicicolin h. |
| AID489684 | Antifungal activity against Candida albicans after 48 hrs by serial dilution method | 2010 | European journal of medicinal chemistry, Jul, Volume: 45, Issue:7 | Benzylidene/2-chlorobenzylidene hydrazides: synthesis, antimicrobial activity, QSAR studies and antiviral evaluation. |
| AID526735 | Antifungal activity against Cryptococcus neoformans KCCM 50564 after 1 day | 2010 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 20, Issue:22 | Synthesis and antifungal activity of benzofuran-5-ols. |
| AID642903 | Antifungal activity against Candida albicans ATCC 90028 | 2011 | ACS medicinal chemistry letters, May-12, Volume: 2, Issue:5 | Natural Product Based 6-Hydroxy-2,3,4,6-tetrahydropyrrolo[1,2-a]pyrimidinium Scaffold as A New Antifungal Template. |
| AID642914 | Antifungal activity against intrinsically fluconazole-resistant Candida glabrata ATCC 90030 | 2011 | ACS medicinal chemistry letters, May-12, Volume: 2, Issue:5 | Natural Product Based 6-Hydroxy-2,3,4,6-tetrahydropyrrolo[1,2-a]pyrimidinium Scaffold as A New Antifungal Template. |
| AID1369462 | Fungicidal activity against fluconazole-resistant Candida albicans 56452 after 96 hrs | 2018 | Journal of medicinal chemistry, 05-10, Volume: 61, Issue:9 | Combating Drug-Resistant Fungi with Novel Imperfectly Amphipathic Palindromic Peptides. |
| AID1706895 | Thiol-reactivity using 13C-labeled La antigen containing reactive cysteine C245 at 400 uM at 37 degreeC for 90 mins in absence of DTT by 2D 1H-13C HMQC ALARM NMR spectroscopy | 2020 | Journal of medicinal chemistry, 12-10, Volume: 63, Issue:23 | Synthesis of Guaianolide Analogues with a Tunable α-Methylene-γ-lactam Electrophile and Correlating Bioactivity with Thiol Reactivity. |
| AID417552 | Antifungal activity against Candida tropicalis 21005 | 2009 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 19, Issue:5 | FR290581, a novel sordarin derivative: synthesis and antifungal activity. |
| AID555577 | Antimicrobial activity against Candida coliculosa by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Activity profile in vitro of micafungin against Spanish clinical isolates of common and emerging species of yeasts and molds. |
| AID1481569 | Antifungal activity against Candida mycoderma after 24 hrs by two-fold serial dilution assay | 2017 | Bioorganic & medicinal chemistry letters, 04-15, Volume: 27, Issue:8 | Novel benzimidazolyl tetrahydroprotoberberines: Design, synthesis, antimicrobial evaluation and multi-targeting exploration. |
| AID1265817 | Antifungal activity against azole-resistant Candida albicans ATCC 90819 after 48 hrs by microbroth dilution method | 2015 | Journal of medicinal chemistry, Dec-10, Volume: 58, Issue:23 | Synthesis and Bioactivities of Kanamycin B-Derived Cationic Amphiphiles. |
| AID1238924 | Antifungal activity against Cryptococcus neoformans Cn18 (Serotype C) WTBF-106 by microbroth dilution method | 2015 | Bioorganic & medicinal chemistry, Sep-01, Volume: 23, Issue:17 | Synthesis and antifungal evaluation of head-to-head and head-to-tail bisamidine compounds. |
| AID516266 | Antimicrobial activity against Cryptococcus gattii serotype B isolate NIH189 assessed as concentration required for heteroresistance | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Heteroresistance of Cryptococcus gattii to fluconazole. |
| AID1904257 | Antifungal activity against Candida albicans 904 assessed as inhibition of fungal growth incubated for 48 hrs by microdilution method | 2022 | Journal of medicinal chemistry, 05-12, Volume: 65, Issue:9 | Discovery of Novel Sertraline Derivatives as Potent Anti- |
| AID518656 | Antimicrobial activity against Cryptococcus gattii serotype B isolate NIH189 assessed as heteroresistant isolates at 8 ug/ml | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Heteroresistance of Cryptococcus gattii to fluconazole. |
| AID762711 | Antimicrobial activity against Aspergillus niger MTCC 281 at 100 ug/ml after 24 hrs by agar disc diffusion method | 2013 | Bioorganic & medicinal chemistry letters, Aug-15, Volume: 23, Issue:16 | Novel pyrazoline amidoxime and their 1,2,4-oxadiazole analogues: synthesis and pharmacological screening. |
| AID1770937 | Antifungal activity against Candida albicans ATCC SC5314 assessed as fungal growth inhibition by CLSI protocol based method | 2021 | European journal of medicinal chemistry, Dec-05, Volume: 225 | Design, synthesis and evaluation of novel 5-phenylthiophene derivatives as potent fungicidal of Candida albicans and antifungal reagents of fluconazole-resistant fungi. |
| AID1770962 | Cytotoxicity against human A549 cells assessed as reduction in cell viability measured after 96 hrs by MTT assay | 2021 | European journal of medicinal chemistry, Dec-05, Volume: 225 | Design, synthesis and evaluation of novel 5-phenylthiophene derivatives as potent fungicidal of Candida albicans and antifungal reagents of fluconazole-resistant fungi. |
| AID323596 | Antifungal activity against Candida krusei bloodstream isolates by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5 | In vitro activities of isavuconazole and other antifungal agents against Candida bloodstream isolates. |
| AID542089 | Antifungal activity against Candida krusei TIMM0269 after 24 hrs by microdilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Discovery of a small-molecule inhibitor of {beta}-1,6-glucan synthesis. |
| AID424900 | Antimicrobial activity against azole-resistant Candida albicans isolate CA10 assessed as growth at 0.25 ug/ml co-treated with 0.008 ug/ml calcineurin signaling inhibitor tacrolimus after 48 hrs by microdilution checkboard technique relative to control | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | In vitro interactions between tacrolimus and azoles against Candida albicans determined by different methods. |
| AID525591 | Antibacterial activity against Fluconazole resistant Candida albicans DSY296 overexpressing multidrug transporter gene CDR1 and CDR2 and containing ERG11 G464S mutation by EUCAST standards based broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Genetic dissection of azole resistance mechanisms in Candida albicans and their validation in a mouse model of disseminated infection. |
| AID405032 | Antifungal activity against Sporothrix schenckii P24223 isolate from cutaneous-lymphatic sporotrichosis patient after 72 hrs by ATB Fungus 2 method | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | In vitro susceptibility of Sporothrix schenckii to six antifungal agents determined using three different methods. |
| AID537529 | Antifungal activity against Candida albicans after 48 hrs by broth microdilution method | 2010 | Bioorganic & medicinal chemistry, Nov-15, Volume: 18, Issue:22 | Synthesis of new antifungal peptides selective against Cryptococcus neoformans. |
| AID1740330 | Antifungal activity against Fusarium solani ATCC 36031 assessed as reduction in fungal growth incubated for 48 hrs by broth microdilution method | 2020 | European journal of medicinal chemistry, Sep-15, Volume: 202 | Design, synthesis and antimicrobial evaluation of novel glycosylated-fluoroquinolones derivatives. |
| AID1525537 | Inhibition of fungal Lanosterol 14-alpha demethylase | 2019 | Journal of medicinal chemistry, 11-27, Volume: 62, Issue:22 | Why Some Targets Benefit from beyond Rule of Five Drugs. |
| AID1759432 | Inhibition of ergosterol biosynthesis in Cryptococcus neoformans PFCC 93-589 cell membrane at 1 times MIC incubated for 48 hrs by UV-visible spectrophotometric analysis | 2021 | Bioorganic & medicinal chemistry letters, 06-01, Volume: 41 | Inhibitory effects and mechanism of antifungal action of the natural cyclic depsipeptide, aureobasidin A against Cryptococcus neoformans. |
| AID54870 | In vitro antifungal activity against Cryptococcus neoformans ATCC 9011 | 2004 | Bioorganic & medicinal chemistry letters, Jan-05, Volume: 14, Issue:1 | Novel galbonolide derivatives as IPC synthase inhibitors: design, synthesis and in vitro antifungal activities. |
| AID424888 | Antimicrobial activity against azole-resistant Candida albicans isolate CA10 assessed as growth at 0.125 ug/ml co-treated with 0.016 ug/ml calcineurin signaling inhibitor tacrolimus after 48 hrs by microdilution checkboard technique relative to control | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | In vitro interactions between tacrolimus and azoles against Candida albicans determined by different methods. |
| AID582229 | Antifungal activity against Candida albicans isolated from neutropenic subjects with AML or MDS receiving posaconazole by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Impact of antifungal prophylaxis on colonization and azole susceptibility of Candida species. |
| AID440342 | Antifungal activity against Aspergillus niger NCIM 617 after 2 to 3 days by serial plate dilution method | 2009 | European journal of medicinal chemistry, Dec, Volume: 44, Issue:12 | Synthesis and antimicrobial activity of some new N-acyl substituted phenothiazines. |
| AID1864933 | Induction of mitochondrial membrane potential loss in Candida albicans ATCC SC5314 assessed as normal cells at 1 umol/ml incubated for 24 hrs by JC-1 staining based flow cytometry assay (Rvb = 95.26%) | |||
| AID43564 | Effect of pre-incubation with enzyme on the inhibition of beta-lactamase:No inhibition | 2003 | Journal of medicinal chemistry, Oct-09, Volume: 46, Issue:21 | Identification and prediction of promiscuous aggregating inhibitors among known drugs. |
| AID1180459 | Selectivity index, ratio of IC50 for human HepG2 cells to MIC for Trichophyton mentagrophytes 445 | 2014 | Bioorganic & medicinal chemistry, Aug-01, Volume: 22, Issue:15 | Synthesis and biological activity of new salicylanilide N,N-disubstituted carbamates and thiocarbamates. |
| AID293784 | Antimicrobial activity against Saccharomyces cerevisiae ATCC 2601 by broth microdilution method | 2007 | Bioorganic & medicinal chemistry, Mar-01, Volume: 15, Issue:5 | Synthesis, antimicrobial activity, and QSAR studies of furan-3-carboxamides. |
| AID29363 | Dissociation constant (pKa) | 2000 | Journal of medicinal chemistry, Jun-29, Volume: 43, Issue:13 | QSAR model for drug human oral bioavailability. |
| AID526821 | Metabolic stability in human liver microsomes at 1 uM after 30 mins | 2010 | Bioorganic & medicinal chemistry, Nov-01, Volume: 18, Issue:21 | 1,3-Benzoxazole-4-carbonitrile as a novel antifungal scaffold of β-1,6-glucan synthesis inhibitors. |
| AID1201586 | Antifungal activity against Candida albicans at 1 mg/ml incubated for 3 days | 2015 | European journal of medicinal chemistry, May-05, Volume: 95 | Synthesis and biological evaluation of new imidazo[2,1-b][1,3,4]thiadiazole-benzimidazole derivatives. |
| AID1911617 | Antifungal activity against Cryptococcus gattii VGII R265 assessed as fungal growth inhibition by broth microdilution assay | 2022 | Journal of medicinal chemistry, 06-09, Volume: 65, Issue:11 | Development of Lipo-γ-AA Peptides as Potent Antifungal Agents. |
| AID608607 | Antimicrobial activity against Staphylococcus aureus ATCC 29213 after 24 hrs by microdilution technique | 2011 | European journal of medicinal chemistry, Jul, Volume: 46, Issue:7 | New condensed pyrroles of potential biological interest syntheses and structure-activity relationship studies. |
| AID584385 | Ratio of URA3 gene expression in Candida glabrata isolated from patient 491 receiving antifungal drug to URA3 gene expression in Candida glabrata isolated from patient 491 by RT-PCR analysis | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Impact of antifungal prophylaxis on colonization and azole susceptibility of Candida species. |
| AID1224555 | Antifungal activity against Aspergillus fumigatus 231 after 24 hrs by broth microdilution method | 2014 | European journal of medicinal chemistry, Jul-23, Volume: 82 | 1-Substituted-5-[(3,5-dinitrobenzyl)sulfanyl]-1H-tetrazoles and their isosteric analogs: A new class of selective antitubercular agents active against drug-susceptible and multidrug-resistant mycobacteria. |
| AID1196907 | Antifungal activity against Candida albicans SC5314 after 24 hrs | 2015 | Journal of medicinal chemistry, Feb-12, Volume: 58, Issue:3 | 2-(2-oxo-morpholin-3-yl)-acetamide derivatives as broad-spectrum antifungal agents. |
| AID417559 | Antifungal activity against Candida albicans FP633 in po dosed ICR mouse assessed as kidney burden per gram of tissue at 20 mg/kg, po after 24 hrs of inoculation | 2009 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 19, Issue:5 | FR290581, a novel sordarin derivative: synthesis and antifungal activity. |
| AID699539 | Inhibition of human liver OATP1B1 expressed in HEK293 Flp-In cells assessed as reduction in E17-betaG uptake at 20 uM by scintillation counting | 2012 | Journal of medicinal chemistry, May-24, Volume: 55, Issue:10 | Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions. |
| AID1610309 | Antifungal activity against fluconazole-resistant Candida albicans isolate 100 incubated for 24 hrs by CLSI protocol based microbroth dilution method | 2019 | Bioorganic & medicinal chemistry letters, 12-01, Volume: 29, Issue:23 | Design, synthesis and biological evaluation of novel semicarbazone-selenochroman-4-ones hybrids as potent antifungal agents. |
| AID332284 | Antimicrobial activity against Candida albicans UCD FRI after 16 to 18 hrs by microbroth dilution assay | 2002 | Journal of natural products, Mar, Volume: 65, Issue:3 | (+)-7S-Hydroxyxestospongin A from the marine sponge Xestospongia sp. and absolute configuration of (+)-xestospongin D. |
| AID555049 | Antimicrobial activity against Candida glabrata by EUCAST method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Breakpoints for susceptibility testing should not divide wild-type distributions of important target species. |
| AID567444 | Antifungal activity against Trichosporon asahii after 48 hrs by Etest | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | In vitro antifungal activities of isavuconazole and comparators against rare yeast pathogens. |
| AID1157177 | Antifungal activity against Microsporum gypseum PMC 7303 after 72 hrs by CLSI broth microdilution method | 2014 | European journal of medicinal chemistry, Aug-18, Volume: 83 | Synthesis, biological evaluation and structure-activity correlation study of a series of imidazol-based compounds as Candida albicans inhibitors. |
| AID525601 | Antibacterial activity against Fluconazole resistant Candida albicans DSY3706 containing tac1delta/delta ERG11-1/ERG11-1 genotype by EUCAST standards based broth microdilution method sCandida albicans DSY294 | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Genetic dissection of azole resistance mechanisms in Candida albicans and their validation in a mouse model of disseminated infection. |
| AID1585623 | Antifungal activity against Candida albicans SC5314 infected in Caenorhabditis elegans assessed as mortality at 20 nM after 24 hrs by propidium iodide staining based fluorescence microscopic analysis (Rvb = 17%) | 2019 | European journal of medicinal chemistry, Jan-15, Volume: 162 | Chemical preparation, biological evaluation and 3D-QSAR of ethoxysulfuron derivatives as novel antifungal agents targeting acetohydroxyacid synthase. |
| AID1783089 | Downregulation of ERG11 mRNA expression in Candida tropicalis 5008 at 4 ug/ml measured after 24 hrs by qRT-PCR analysis | 2021 | European journal of medicinal chemistry, Oct-05, Volume: 221 | Lanosterol 14α-demethylase (CYP51)/histone deacetylase (HDAC) dual inhibitors for treatment of Candida tropicalis and Cryptococcus neoformans infections. |
| AID405077 | Antifungal activity against Sporothrix schenckii isolate from cutaneous-lymphatic sporotrichosis patient after 72 hrs by ATB Fungus 2 method | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | In vitro susceptibility of Sporothrix schenckii to six antifungal agents determined using three different methods. |
| AID762385 | Antifungal activity against Saccharomyces cerevisiae ATCC 9763 after 24 to 72 hrs by microdilution method | 2013 | European journal of medicinal chemistry, Aug, Volume: 66 | Synthesis, in vitro antifungal activity and in silico study of 3-(1,2,4-triazol-1-yl)flavanones. |
| AID425149 | Antimicrobial activity against azole-resistant Candida albicans isolate CA10 assessed as growth at 0.031 ug/ml after 48 hrs by microdilution checkerboard technique relative to control | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | In vitro interactions between tacrolimus and azoles against Candida albicans determined by different methods. |
| AID462260 | Antifungal activity against pharmacoresistant Candida albicans AIDS68 infected in Wistar rat estrogen-dependent fungal vaginitis model assessed as fungal burden at 10 ug administered intravaginally 48 hrs after fungal infection measured on day 28 after in | 2010 | Journal of medicinal chemistry, Mar-25, Volume: 53, Issue:6 | Identification of inhibitors of drug-resistant Candida albicans strains from a library of bicyclic peptidomimetic compounds. |
| AID581884 | Antifungal activity against Candida glabrata isolated from HSCT recipient 270 with acute or chronic GVHD mouth after 108 days prophylaxis by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Impact of antifungal prophylaxis on colonization and azole susceptibility of Candida species. |
| AID352099 | Antimicrobial activity against multidrug-resistant Candida albicans isolates after 24 to 48 hrs | 2009 | European journal of medicinal chemistry, Feb, Volume: 44, Issue:2 | Synthesis, biological evaluation and 2D-QSAR analysis of benzoxazoles as antimicrobial agents. |
| AID428419 | Antifungal activity against Trichophyton mentagrophytes after 48 hrs by agar dilution method | 2009 | European journal of medicinal chemistry, Jul, Volume: 44, Issue:7 | Design, synthesis, and antifungal activity of triazole and benzotriazole derivatives. |
| AID371233 | Antimicrobial activity against Candida tropicalis ATCC 750 by broth microdilution method | 2008 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 18, Issue:24 | Carbon analogs of antifungal dioxane-triazole derivatives: synthesis and in vitro activities. |
| AID555576 | Antimicrobial activity against Candida pelliculosa by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Activity profile in vitro of micafungin against Spanish clinical isolates of common and emerging species of yeasts and molds. |
| AID405048 | Antifungal activity against Sporothrix schenckii P26187 isolate from cutaneous-lymphatic sporotrichosis patient after 72 hrs by modified NCCLS M38-A method | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | In vitro susceptibility of Sporothrix schenckii to six antifungal agents determined using three different methods. |
| AID1155873 | Antifungal activity against Aspergillus fumigatus assessed as growth inhibition after 7 days by serial dilution method | 2014 | European journal of medicinal chemistry, Jul-23, Volume: 82 | Design, synthesis and antifungal activity of novel triazole derivatives containing substituted 1,2,3-triazole-piperdine side chains. |
| AID653257 | Antifungal activity against Candida glabrata ATCC 90030 after 24 hrs by broth microdilution method | 2012 | Bioorganic & medicinal chemistry, Apr-15, Volume: 20, Issue:8 | Semisynthesis and antimicrobial activity of novel guttiferone-A derivatives. |
| AID1689230 | Antibacterial activity against Lactobacillus crispatus HM-370 assessed as reduction in bacterial growth by CLSI based assay | 2020 | European journal of medicinal chemistry, Mar-01, Volume: 189 | Oxadiazolylthiazoles as novel and selective antifungal agents. |
| AID547568 | Antifungal activity against Candida dubliniensis after 24 to 72 hrs by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | In vitro antifungal activities of bis(alkylpyridinium)alkane compounds against pathogenic yeasts and molds. |
| AID1610311 | Antifungal activity against fluconazole-resistant Candida albicans isolate 17 incubated for 24 hrs by CLSI protocol based microbroth dilution method | 2019 | Bioorganic & medicinal chemistry letters, 12-01, Volume: 29, Issue:23 | Design, synthesis and biological evaluation of novel semicarbazone-selenochroman-4-ones hybrids as potent antifungal agents. |
| AID1242649 | Antifungal activity against Trichophyton mentagrophytes after 16 hrs by microtiter broth dilution method | 2015 | ACS medicinal chemistry letters, Jul-09, Volume: 6, Issue:7 | Novel Chalcone-Thiazole Hybrids as Potent Inhibitors of Drug Resistant Staphylococcus aureus. |
| AID50321 | Compound was tested in vitro for antifungal activity against Candida neoformans (CY1057) | 1998 | Bioorganic & medicinal chemistry letters, Jul-21, Volume: 8, Issue:14 | Modeling, synthesis and biological activity of novel antifungal agents (1). |
| AID1904285 | Inhibition of Cryptococcus neoformans H99 delta5,6-desaturase assessed as upregulation of ERG1 gene expression at 2 ug/ml incubated for 24 hrs by RT-PCR analysis | 2022 | Journal of medicinal chemistry, 05-12, Volume: 65, Issue:9 | Discovery of Novel Sertraline Derivatives as Potent Anti- |
| AID1877286 | Antifungal activity against Aspergillus fumigatus CGMCC3.7795 assessed as fungal growth inhibition by NCCLS protocol based method | 2022 | European journal of medicinal chemistry, Jan-05, Volume: 227 | Broadening antifungal spectrum and improving metabolic stablity based on a scaffold strategy: Design, synthesis, and evaluation of novel 4-phenyl-4,5-dihydrooxazole derivatives as potent fungistatic and fungicidal reagents. |
| AID415953 | Antimicrobial activity against Trichophyton rubrum by micro-broth dilution method | 2009 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 19, Issue:6 | Design, synthesis, and biological evaluation of novel 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-substituted benzylamino-2-propanols. |
| AID50137 | Minimum inhibitory concentration of compound for antifungal activity against Candida kefyr | 2000 | Bioorganic & medicinal chemistry letters, Oct-02, Volume: 10, Issue:19 | Novel antifungals based on 4-substituted imidazole: a combinatorial chemistry approach to lead discovery and optimization. |
| AID554705 | Antimicrobial activity against Candida krusei B2399 after 48 hrs by liquid microdilution assay | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Abc1p is a multidrug efflux transporter that tips the balance in favor of innate azole resistance in Candida krusei. |
| AID1494181 | Antifungal activity against Candida krusei ATCC 6258 measured after 48 hrs by CLSI M27-A3 protocol based method | 2018 | Bioorganic & medicinal chemistry, 02-01, Volume: 26, Issue:3 | Novel fluconazole derivatives with promising antifungal activity. |
| AID340949 | Antifungal activity against Candida albicans isolates from HIV infected patient before fluconazole therapy by NCCLS M27-A2 method | 2007 | Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8 | Cross-resistance to medical and agricultural azole drugs in yeasts from the oropharynx of human immunodeficiency virus patients and from environmental Bavarian vine grapes. |
| AID1451801 | Antifungal activity against Trichophyton mentagrophytes after 7 days | 2017 | Journal of medicinal chemistry, 10-12, Volume: 60, Issue:19 | Novel Inhibitors of Staphyloxanthin Virulence Factor in Comparison with Linezolid and Vancomycin versus Methicillin-Resistant, Linezolid-Resistant, and Vancomycin-Intermediate Staphylococcus aureus Infections in Vivo. |
| AID1762154 | Antifungal activity against Candida albicans CBS 8837 assessed as reduction in fungal growth incubated for 24 hrs by CLSI based serial microbroth dilution method | 2021 | Bioorganic & medicinal chemistry letters, 05-15, Volume: 40 | Synthesis and antifungal activity of new hybrids thiazolo[4,5-d]pyrimidines with (1H-1,2,4)triazole. |
| AID1067045 | Antifungal activity against Aspergillus fumigatus by micro-broth dilution method | 2014 | European journal of medicinal chemistry, Mar-03, Volume: 74 | Synthesis, antifungal activities and molecular docking studies of novel 2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propyl dithiocarbamates. |
| AID477745 | Antimicrobial activity against Trichophyton mentagrophytes after 24 hrs | 2010 | European journal of medicinal chemistry, Apr, Volume: 45, Issue:4 | An eco-friendly synthesis and antimicrobial activities of dihydro-2H-benzo- and naphtho-1,3-oxazine derivatives. |
| AID1497599 | Antifungal activity against fluconazole-resistant Candida albicans isolate 111 after 24 hrs by broth microdilution method | 2018 | Bioorganic & medicinal chemistry letters, 07-15, Volume: 28, Issue:13 | Benzofuro[3,2-d]pyrimidines inspired from cercosporamide CaPkc1 inhibitor: Synthesis and evaluation of fluconazole susceptibility restoration. |
| AID1898152 | Antifungal activity against Aspergillus fumigatus 7544 incubated for 48 hrs by microbroth dilution method | |||
| AID269980 | Antifungal activity against Candida glabrata 566 | 2006 | Journal of medicinal chemistry, Aug-10, Volume: 49, Issue:16 | Synthesis and antifungal activity of a novel series of alkyldimethylamine cyanoboranes and their derivatives. |
| AID608755 | Antifungal activity against Aspergillus niger at 500 ug/ml after 72 hrs by agar diffusion method | 2011 | European journal of medicinal chemistry, Aug, Volume: 46, Issue:8 | Synthesis, characterization and antimicrobial studies of some new pyrazole incorporated imidazole derivatives. |
| AID584380 | Ratio of ERG11 gene expression in Candida glabrata isolated from patient 807 receiving antifungal drug to ERG11 gene expression in Candida glabrata isolated from patient 807 by RT-PCR analysis | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Impact of antifungal prophylaxis on colonization and azole susceptibility of Candida species. |
| AID1244347 | Antifungal activity against Candida parapsilosis ATCC 22019 incubated for 48 hrs by broth micro-dilution method | 2015 | European journal of medicinal chemistry, Aug-28, Volume: 101 | N-Alkyl/aryl-4-(3-substituted-3-phenylpropyl)piperazine-1-carbothioamide as dual-action vaginal microbicides with reverse transcriptase inhibition. |
| AID392370 | Antifungal activity against Candida krusei E28 after 48 hrs by broth microdilution method | 2009 | Bioorganic & medicinal chemistry letters, Jan-15, Volume: 19, Issue:2 | Salicylanilide esters of N-protected amino acids as novel antimicrobial agents. |
| AID480475 | Antifungal activity against Candida tropicalis after 24 hrs by serial dilution method | 2010 | Bioorganic & medicinal chemistry letters, May-01, Volume: 20, Issue:9 | Structure-based rational design, synthesis and antifungal activity of oxime-containing azole derivatives. |
| AID584386 | Antifungal activity against 29 days cultured Candida glabrata isolated from neutropenic subject with AML or MDS pharynx after 48 days of prophylaxis by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Impact of antifungal prophylaxis on colonization and azole susceptibility of Candida species. |
| AID1374422 | Antifungal activity against Candida glabrata ATCC 90030 after 48 hrs by microdilution broth method | 2018 | Bioorganic & medicinal chemistry letters, 03-01, Volume: 28, Issue:5 | Synthesis, antimicrobial activity and acid dissociation constants of methyl 5,5-diphenyl-1-(thiazol-2-yl)pyrrolidine-2-carboxylate derivatives. |
| AID1770941 | Antifungal activity against Candida parapsilosis GIM2.190 assessed as fungal growth inhibition by CLSI protocol based method | 2021 | European journal of medicinal chemistry, Dec-05, Volume: 225 | Design, synthesis and evaluation of novel 5-phenylthiophene derivatives as potent fungicidal of Candida albicans and antifungal reagents of fluconazole-resistant fungi. |
| AID1427205 | Antifungal activity against Candida glabrata 20/I after 48 hrs by microdilution broth assay | 2017 | Bioorganic & medicinal chemistry, 03-15, Volume: 25, Issue:6 | Antimicrobial activity of rhodanine-3-acetic acid derivatives. |
| AID395784 | Antifungal activity against Candida krusei ATCC 6258 after 48 hrs by twofold serial dilution technique | 2008 | European journal of medicinal chemistry, Nov, Volume: 43, Issue:11 | Synthesis, antimicrobial activity, pharmacophore analysis of some new 2-(substitutedphenyl/benzyl)-5-[(2-benzofuryl)carboxamido]benzoxazoles. |
| AID1239970 | Antifungal activity against Candida albicans ATCC 10231 after 24 hrs by microbroth dilution method | 2015 | Bioorganic & medicinal chemistry letters, Sep-01, Volume: 25, Issue:17 | Design and biological evaluation of novel quinolone-based metronidazole derivatives as potent Cu(2+) mediated DNA-targeting antibacterial agents. |
| AID367161 | Antimicrobial activity against Aspergillus fumigatus by broth microdilution method | 2009 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 19, Issue:3 | Synthesis and antifungal activity of 1,2,3-triazole containing fluconazole analogues. |
| AID521509 | Antifungal activity against Aspergillus fumigatus ATCC 16424 after 48 hrs by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | In vitro and in vivo antifungal activities of T-2307, a novel arylamidine. |
| AID1495963 | Fungicidal activity against Microsporum gypseum measured after 96 hrs | 2018 | Bioorganic & medicinal chemistry, 07-23, Volume: 26, Issue:12 | Efficiency of newly prepared thiazole derivatives against some cutaneous fungi. |
| AID457992 | Antifungal activity against Candida lusitaniae 2446/I after 48 hrs by microdilution method | 2010 | Bioorganic & medicinal chemistry, Mar-01, Volume: 18, Issue:5 | Antifungal 3,5-disubstituted furanones: From 5-acyloxymethyl to 5-alkylidene derivatives. |
| AID407060 | Antimicrobial activity against Candida albicans SC5314 dissociated biofilms grown on polyvinylchloride catheter surface at cell density of 10'8 cells/ml at 0.25 to 8 ug/ml by XTT assay | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | Role for cell density in antifungal drug resistance in Candida albicans biofilms. |
| AID405111 | Antimicrobial activity against Absidia corymbifera assessed as percent of susceptible isolates after 24 hrs | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | In vitro susceptibilities of 217 clinical isolates of zygomycetes to conventional and new antifungal agents. |
| AID555569 | Antimicrobial activity against Candida glabrata by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Activity profile in vitro of micafungin against Spanish clinical isolates of common and emerging species of yeasts and molds. |
| AID1309072 | Antifungal activity against Candida tropicalis ATCC 13803 after 48 hrs by agar dilution method | 2016 | Bioorganic & medicinal chemistry, 08-15, Volume: 24, Issue:16 | Novel benzimidazol-2-ylidene carbene precursors and their silver(I) complexes: Potential antimicrobial agents. |
| AID1864958 | Immunostimulatory activity in mouse infected with Candida albicans ATCC SC5314 assessed as reduction in PD-L1 expression in spleen by western blot analysis relative to control | |||
| AID1898212 | Antifungal activity against Candida albicans SC5314 infected in ICR mouse assessed as median survival time at 0.5 mg/kg, po qd infected with fungus for 2 hrs prior to compound addition for 7 days and measured for 20 days | |||
| AID1598040 | Antifungal activity against Candida albicans ATCC SC5314 after 24 hrs | 2019 | European journal of medicinal chemistry, May-15, Volume: 170 | Current advances of triazole alcohols derived from fluconazole: Design, in vitro and in silico studies. |
| AID555000 | Antifungal activity against Candida parapsilosis assessed as dose dependent percent susceptible isolates at 25 ug/disc by CLSI M44-A disk diffusion method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | In vitro activities of fluconazole and voriconazole against clinical isolates of Candida spp. determined by disk diffusion testing in Turin, Italy. |
| AID608608 | Antimicrobial activity against Escherichia coli ATCC 25922 after 24 hrs by microdilution technique | 2011 | European journal of medicinal chemistry, Jul, Volume: 46, Issue:7 | New condensed pyrroles of potential biological interest syntheses and structure-activity relationship studies. |
| AID1235430 | Antifungal activity against Candida tropicalis ATCC 750 by broth microdilution assay | 2015 | Bioorganic & medicinal chemistry, Aug-01, Volume: 23, Issue:15 | Imidazole clubbed 1,3,4-oxadiazole derivatives as potential antifungal agents. |
| AID369395 | Antimicrobial activity against Trichosporon loubieri isolate | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | In vitro susceptibility to posaconazole of 1,903 yeast isolates recovered in France from 2003 to 2006 and tested by the method of the European committee on antimicrobial susceptibility testing. |
| AID555019 | Antifungal activity against Candida parapsilosis by reference dilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | In vitro activities of fluconazole and voriconazole against clinical isolates of Candida spp. determined by disk diffusion testing in Turin, Italy. |
| AID679463 | TP_TRANSPORTER: inhibition of Daunorubicin transport in G185 cells | 2002 | Antimicrobial agents and chemotherapy, Jan, Volume: 46, Issue:1 | Interaction of common azole antifungals with P glycoprotein. |
| AID609974 | Antifungal activity against Rhizopus sp. at 500 ug after 24 hrs by paper disc technique | 2011 | Bioorganic & medicinal chemistry letters, Aug-15, Volume: 21, Issue:16 | Efficient synthesis of antifungal active 9-substituted-3-aryl-5H,13aH-quinolino[3,2-f][1,2,4]triazolo[4,3-b][1,2,4]triazepines in ionic liquids. |
| AID12529 | Pharmacokinetic property when administered intravenously in rat at 2 mg/kg | 2003 | Bioorganic & medicinal chemistry letters, Jan-06, Volume: 13, Issue:1 | Design and synthesis of novel benzofurans as a new class of antifungal agents targeting fungal N-myristoyltransferase. Part 3. |
| AID262553 | Antifungal activity against Sporothrix schenckii | 2006 | Journal of medicinal chemistry, Apr-20, Volume: 49, Issue:8 | Structure-based optimization of azole antifungal agents by CoMFA, CoMSIA, and molecular docking. |
| AID725884 | Antifungal activity against fluconazole-susceptible Candida albicans CAAL97 after 24 hrs by spectrofluorometric analysis | 2013 | ACS medicinal chemistry letters, Feb-14, Volume: 4, Issue:2 | Discovery of a novel broad-spectrum antifungal agent derived from albaconazole. |
| AID214430 | Minimum inhibitory concentration of compound for antifungal activity against Trichophyton rubrum | 2000 | Bioorganic & medicinal chemistry letters, Oct-02, Volume: 10, Issue:19 | Novel antifungals based on 4-substituted imidazole: a combinatorial chemistry approach to lead discovery and optimization. |
| AID584409 | Antifungal activity against -3 days cultured Candida tropicalis isolated from neutropenic subject with AML or MDS stool receiving antifungal therapy for 45 days after 24 days of prophylaxis by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Impact of antifungal prophylaxis on colonization and azole susceptibility of Candida species. |
| AID356361 | Antifungal activity against fluconazole-resistant Candida albicans isolate 5 after 24 to 48 hrs by NCCLS method | 2003 | Journal of natural products, Aug, Volume: 66, Issue:8 | Acetylenic acids inhibiting azole-resistant Candida albicans from Pentagonia gigantifolia. |
| AID582250 | Antifungal activity against Candida albicans isolated from neutropenic subjects with AML or MDS receiving fluconazole by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Impact of antifungal prophylaxis on colonization and azole susceptibility of Candida species. |
| AID1758039 | Inhibition of CYP51 in Candida albicans ATCC SC5314 assessed as lanosterol level at 2 ug/ml after 16 hrs by GC-MS analysis (Rvb = 1.7%) | 2021 | European journal of medicinal chemistry, Apr-15, Volume: 216 | Lead optimization generates selenium-containing miconazole CYP51 inhibitors with improved pharmacological profile for the treatment of fungal infections. |
| AID1783809 | Inhibition of Candida albicans CYP51 assessed as lanosterol level at 0.25 ug/ml measured after 18 hrs by GC-MS analysis relative to control | 2021 | European journal of medicinal chemistry, Nov-15, Volume: 224 | Improving the metabolic stability of antifungal compounds based on a scaffold hopping strategy: Design, synthesis, and structure-activity relationship studies of dihydrooxazole derivatives. |
| AID518879 | Antimicrobial activity against Cryptococcus gattii serotype B isolate NIH444 assessed as heteroresistant isolates at 32 ug/ml | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Heteroresistance of Cryptococcus gattii to fluconazole. |
| AID1154029 | Antifungal activity against Cryptococcus neoformans after 48 hrs by disc diffusion method | 2014 | Bioorganic & medicinal chemistry, Jul-01, Volume: 22, Issue:13 | Design, synthesis and evaluation of novel quinazoline-2,4-dione derivatives as chitin synthase inhibitors and antifungal agents. |
| AID467906 | Antifungal activity against Trichophyton mentagrophytes after 48 hrs by broth microdilution technique | 2010 | European journal of medicinal chemistry, Feb, Volume: 45, Issue:2 | Imidazole derivatives as possible microbicides with dual protection. |
| AID1359822 | Antifungal activity against Aspergillus fumigatus GIMCC 3.19 measured after 48 hrs by two-dimensional broth microdilution checkboard method | |||
| AID319756 | Antimicrobial activity against Microsporum gypseum isolates | 2008 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 18, Issue:11 | Synthesis and SAR studies of biaryloxy-substituted triazoles as antifungal agents. |
| AID1125791 | Antibacterial activity against Staphylococcus aureus MTCC 4102 assessed as diameter of growth inhibition zone at 10 ug/ml after 20 hrs by agar disc diffusion method | 2014 | European journal of medicinal chemistry, Apr-22, Volume: 77 | New polyfunctional imidazo[4,5-C]pyridine motifs: synthesis, crystal studies, docking studies and antimicrobial evaluation. |
| AID1707515 | Effect on MDR1 mRNA expression in Candida albicans 0304103 at 32 ug/ml incubated for 24 hrs by RT-PCR analysis | 2021 | Journal of medicinal chemistry, 01-28, Volume: 64, Issue:2 | Novel Carboline Fungal Histone Deacetylase (HDAC) Inhibitors for Combinational Treatment of Azole-Resistant Candidiasis. |
| AID1671797 | Antifungal activity against Aspergillus fumigatus assessed as inhibition of fungal growth after 24 hrs by CLSI protocol based two fold serial dilution method | 2019 | European journal of medicinal chemistry, Apr-01, Volume: 167 | Design and synthesis of aminothiazolyl norfloxacin analogues as potential antimicrobial agents and their biological evaluation. |
| AID1726237 | Hemolytic activity in human RBC by spectrophotometry | |||
| AID619084 | Antifungal activity against Candida glabrata ATCC 90030 by broth dilution method | 2011 | Journal of medicinal chemistry, Oct-13, Volume: 54, Issue:19 | High-throughput-screening-based identification and structure-activity relationship characterization defined (S)-2-(1-aminoisobutyl)-1-(3-chlorobenzyl)benzimidazole as a highly antimycotic agent nontoxic to cell lines. |
| AID1762166 | Antifungal activity against Microsporum canis B-200 assessed as reduction in fungal growth incubated for 24 hrs by CLSI based serial microbroth dilution method | 2021 | Bioorganic & medicinal chemistry letters, 05-15, Volume: 40 | Synthesis and antifungal activity of new hybrids thiazolo[4,5-d]pyrimidines with (1H-1,2,4)triazole. |
| AID531466 | Antifungal activity against Candida krusei assessed as susceptible dose-dependent isolates after 48 hrs by CLSI method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | In vitro susceptibilities of invasive isolates of Candida species: rapid increase in rates of fluconazole susceptible-dose dependent Candida glabrata isolates. |
| AID516312 | Antimicrobial activity against Cryptococcus gattii serotype B isolate NIH76 assessed as concentration required for heteroresistance | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Heteroresistance of Cryptococcus gattii to fluconazole. |
| AID1246770 | Selectivity index, ratio of IC50 for C57BL/6 mouse peritoneal macrophages to MIC for Cryptococcus neoformans ATCC 24067 | 2015 | European journal of medicinal chemistry, Sep-18, Volume: 102 | Thiazole compounds with activity against Cryptococcus gattii and Cryptococcus neoformans in vitro. |
| AID1911616 | Antifungal activity against Cryptococcus neoformans 5-FC assessed as fungal growth inhibition by broth microdilution assay | 2022 | Journal of medicinal chemistry, 06-09, Volume: 65, Issue:11 | Development of Lipo-γ-AA Peptides as Potent Antifungal Agents. |
| AID582783 | Antifungal activity against Candida albicans isolate 490 harboring ERG3 D147G, T330A, A351V and ERG11 F72S, T229A, E266D, N440S, V488I, R523G mutant genes assessed as 14alpha-methylergosta-8,24(28)-dien-3beta,6alpha-diol content in total sterol compositio | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | Identification and characterization of four azole-resistant erg3 mutants of Candida albicans. |
| AID526733 | Antifungal activity against Candida tropicalis KCCM 50662 after 1 day | 2010 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 20, Issue:22 | Synthesis and antifungal activity of benzofuran-5-ols. |
| AID371241 | Antimicrobial activity against Candida albicans 427 infected ddY mouse assessed as survival rate at 20 mg/kg, po administered after 1 hr, 4 hrs, 24 hrs of infection | 2008 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 18, Issue:24 | Carbon analogs of antifungal dioxane-triazole derivatives: synthesis and in vitro activities. |
| AID1473739 | Inhibition of human MRP2 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and GSH measured after 20 mins by membrane vesicle transport assay | 2013 | Toxicological sciences : an official journal of the Society of Toxicology, Nov, Volume: 136, Issue:1 | A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. |
| AID211472 | Evaluation of In vitro antifungal activity against Torulopsis glabrata 78 by broth macro dilution method | 1995 | Journal of medicinal chemistry, Sep-29, Volume: 38, Issue:20 | Synthesis and antifungal activity of new azole derivatives containing an N-acylmorpholine ring. |
| AID750200 | Antifungal activity against Rhodotorula species after 48 hrs by CLSI M27A3 broth microdilution method | 2013 | European journal of medicinal chemistry, Jun, Volume: 64 | Synthesis, antifungal and cytotoxic activities of 2-aryl-3-((piperidin-1-yl)ethyl)thiazolidinones. |
| AID754918 | Antifungal activity against Aspergillus fumigatus 231 assessed as growth inhibition after 24 to 48 hrs by microbroth dilution method | 2013 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 23, Issue:12 | Synthesis and antimycobacterial evaluation of N-substituted 5-chloropyrazine-2-carboxamides. |
| AID1168348 | Ratio of binding constant for human serum albumin in presence of Co2+ to binding constant for human serum albumin in absence of metal ions | 2014 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 24, Issue:21 | Study the interactions between human serum albumin and two antifungal drugs: fluconazole and its analogue DTP. |
| AID581867 | Antifungal activity against Candida albicans isolated from HSCT recipient 301 with acute or chronic GVHD mouth receiving antifungal drug after 114 days prophylaxis by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Impact of antifungal prophylaxis on colonization and azole susceptibility of Candida species. |
| AID1383919 | Antifungal activity against Candida utilis after 24 hrs by NCCLS micro broth dilution method | 2018 | European journal of medicinal chemistry, Apr-25, Volume: 150 | Molecular interaction of novel benzothiazolyl triazolium analogues with calf thymus DNA and HSA-their biological investigation as potent antimicrobial agents. |
| AID1738734 | Inhibition of CYP51 in azole-resistant Candida albicans ATCC SC531 assessed as Obtusifoliol level at 0.125 ug/ml incubated for 16 hrs by LC-MS analysis relative to control | 2020 | European journal of medicinal chemistry, Jul-15, Volume: 198 | Design, synthesis, and biological evaluation of novel miconazole analogues containing selenium as potent antifungal agents. |
| AID1411852 | Antifungal activity against fluconazole susceptible Candida albicans 003gr by CLSI protocol based broth microdilution method | 2017 | MedChemComm, Dec-01, Volume: 8, Issue:12 | Synergistic antifungal effect of cyclized chalcone derivatives and fluconazole against |
| AID436742 | Antifungal activity against Trichophyton rubrum after 7 days by serial dilution method | 2009 | European journal of medicinal chemistry, Oct, Volume: 44, Issue:10 | New azoles with potent antifungal activity: design, synthesis and molecular docking. |
| AID1369463 | Fungicidal activity against fluconazole-resistant Candida albicans 56214 after 96 hrs | 2018 | Journal of medicinal chemistry, 05-10, Volume: 61, Issue:9 | Combating Drug-Resistant Fungi with Novel Imperfectly Amphipathic Palindromic Peptides. |
| AID1246663 | Antifungal activity against Cryptococcus gattii 135L/03 assessed as reduction in cell viability at 26 uM after 6 to 72 hrs by MTT assay | 2015 | European journal of medicinal chemistry, Sep-18, Volume: 102 | Thiazole compounds with activity against Cryptococcus gattii and Cryptococcus neoformans in vitro. |
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| AID1498763 | Antifungal activity against Candida mycoderma after 24 hrs by two fold serial dilution based spectrophotometric analysis | 2018 | Bioorganic & medicinal chemistry letters, 08-01, Volume: 28, Issue:14 | Azoalkyl ether imidazo[2,1-b]benzothiazoles as potentially antimicrobial agents with novel structural skeleton. |
| AID545273 | Antifungal activity against Candida glabrata 20/I after 48 hrs by broth microdilution method | 2010 | European journal of medicinal chemistry, Dec, Volume: 45, Issue:12 | New amino acid esters of salicylanilides active against MDR-TB and other microbes. |
| AID625834 | Antifungal activity against Aspergillus fumigatus by broth microdilution method | 2011 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 21, Issue:21 | Micelles catalyzed chemoselective synthesis 'in water' and biological evaluation of oxygen containing hetero-1,4-naphthoquinones as potential antifungal agents. |
| AID1369448 | Antifungal activity against Candida albicans isolated from alveolar fluid after 48 hrs by broth microdilution method | 2018 | Journal of medicinal chemistry, 05-10, Volume: 61, Issue:9 | Combating Drug-Resistant Fungi with Novel Imperfectly Amphipathic Palindromic Peptides. |
| AID1740168 | Antifungal activity against Cryptococcus neoformans ATCC 208821 measured after 24 hrs by resazurin dye based assay | 2020 | European journal of medicinal chemistry, Sep-01, Volume: 201 | Synthesis, antibacterial and antifungal activity of new 3-biphenyl-3H-Imidazo[1,2-a]azepin-1-ium bromides. |
| AID1413581 | Antifungal activity against fluconazole-resistant Candida albicans 103 by broth microdilution method | |||
| AID1380528 | Antibiofilm eradication activity against Candida albicans ATCC 90028 grown on polystyrene surface assessed as inhibition of mature biofilm formation added 24 hrs after biofilm maturation and measured after 48 hrs by MTT assay | 2018 | Bioorganic & medicinal chemistry letters, 06-01, Volume: 28, Issue:10 | Biofilm inhibition and anti-Candida activity of a cationic lipo-benzamide molecule with twin-nonyl chain. |
| AID382544 | Antifungal activity against Rhodothece nigricans SYM 2417 after 48 hrs standard broth microdilution method | 2008 | European journal of medicinal chemistry, Jan, Volume: 43, Issue:1 | Synthesis, structure and biological activity of pseudopeptidic macrolides based on an amino alcohol. |
| AID561421 | Antifungal activity against fcy1(1-26)-deficient Candida lusitaniae by microdilution method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Nonsense and missense mutations in FCY2 and FCY1 genes are responsible for flucytosine resistance and flucytosine-fluconazole cross-resistance in clinical isolates of Candida lusitaniae. |
| AID1506728 | Antifungal activity against Candida albicans MTCC 9062 | 2017 | MedChemComm, Mar-01, Volume: 8, Issue:3 | Design, synthesis, molecular-docking and antimycobacterial evaluation of some novel 1,2,3-triazolyl xanthenones. |
| AID457990 | Antifungal activity against Candida glabrata 20/I after 48 hrs by microdilution method | 2010 | Bioorganic & medicinal chemistry, Mar-01, Volume: 18, Issue:5 | Antifungal 3,5-disubstituted furanones: From 5-acyloxymethyl to 5-alkylidene derivatives. |
| AID1565878 | Antifungal activity against Cryptococcus neoformans ATCC 32719 assessed as growth inhibition measured after 24 hrs by two-fold broth dilution method | 2019 | European journal of medicinal chemistry, Nov-15, Volume: 182 | Design, synthesis and biological evaluation of novel diazaspiro[4.5]decan-1-one derivatives as potential chitin synthase inhibitors and antifungal agents. |
| AID1689225 | Antifungal activity against Cryptococcus gattii NR43209 assessed as reduction in fungal growth incubated for 48 hrs by CLSI based broth microdilution method | 2020 | European journal of medicinal chemistry, Mar-01, Volume: 189 | Oxadiazolylthiazoles as novel and selective antifungal agents. |
| AID448159 | Antimicrobial activity against Enterococcus faecalis ATCC 29212 at 5 ug after 18 hrs by well diffusion method | 2009 | European journal of medicinal chemistry, Nov, Volume: 44, Issue:11 | Synthesis of some new 1,2,4-triazoles starting from isonicotinic acid hydrazide and evaluation of their antimicrobial activities. |
| AID1076261 | Antibacterial activity against Escherichia coli assessed as growth inhibition by microdilution broth susceptibility assay | 2014 | European journal of medicinal chemistry, Mar-21, Volume: 75 | Synthesis, docking and evaluation of antioxidant and antimicrobial activities of novel 1,2,4-triazolo[3,4-b][1,3,4]thiadiazol-6-yl)selenopheno[2,3-d]pyrimidines. |
| AID1413584 | Inhibition of CYP51 in Candida albicans SC5314 assessed as obtusifoliol content at 8 ug/ml after 16 hrs by GC/MS analysis relative to control | |||
| AID1246594 | Antifungal activity against Cryptococcus neoformans 28JF after 48 to 72 hrs by broth microdilution method | 2015 | European journal of medicinal chemistry, Sep-18, Volume: 102 | Thiazole compounds with activity against Cryptococcus gattii and Cryptococcus neoformans in vitro. |
| AID1265643 | Antifungal activity against Candida krusei clinical isolate after 24 hrs by sabouraud dextrose broth based microdilution method | 2016 | European journal of medicinal chemistry, Jan-01, Volume: 107 | Anti-Candida activity and cytotoxicity of a large library of new N-substituted-1,3-thiazolidin-4-one derivatives. |
| AID521499 | Antifungal activity against Candida krusei IFO 0584 after 48 hrs by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | In vitro and in vivo antifungal activities of T-2307, a novel arylamidine. |
| AID262552 | Antifungal activity against Trichophyton rubrum | 2006 | Journal of medicinal chemistry, Apr-20, Volume: 49, Issue:8 | Structure-based optimization of azole antifungal agents by CoMFA, CoMSIA, and molecular docking. |
| AID274123 | Antifungal activity against Cryptococcus neoformans after 72 hrs | 2006 | Bioorganic & medicinal chemistry letters, Oct-15, Volume: 16, Issue:20 | Design, synthesis, and antifungal activities in vitro of novel tetrahydroisoquinoline compounds based on the structure of lanosterol 14alpha-demethylase (CYP51) of fungi. |
| AID555048 | Antimicrobial activity against Candida parapsilosis ATCC 21019 by EUCAST method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Breakpoints for susceptibility testing should not divide wild-type distributions of important target species. |
| AID567448 | Antifungal activity against Trichosporon sp. after 4 days by Etest | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | In vitro antifungal activities of isavuconazole and comparators against rare yeast pathogens. |
| AID1265816 | Antifungal activity against azole-susceptible Candida albicans ATCC MYA-2876 after 48 hrs by microbroth dilution method | 2015 | Journal of medicinal chemistry, Dec-10, Volume: 58, Issue:23 | Synthesis and Bioactivities of Kanamycin B-Derived Cationic Amphiphiles. |
| AID249325 | Minimum inhibitory concentration to inhibit 90% of the isolates | 2004 | Journal of medicinal chemistry, Jul-29, Volume: 47, Issue:16 | Imidazole analogues of fluoxetine, a novel class of anti-Candida agents. |
| AID356364 | Antifungal activity against fluconazole-resistant Candida albicans isolate 17 at 100 ug/mL after 24 to 48 hrs by NCCLS method | 2003 | Journal of natural products, Aug, Volume: 66, Issue:8 | Acetylenic acids inhibiting azole-resistant Candida albicans from Pentagonia gigantifolia. |
| AID493517 | Antifungal activity against Candida glabrata 20/I after 24 hrs by broth microdilution assay | 2010 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 20, Issue:15 | N-Benzylsalicylthioamides as novel compounds with promising antimycotic activity. |
| AID424647 | Antimicrobial activity against azole-resistant Candida albicans isolate CA10 assessed as growth at 64 ug/ml co-treated with 0.125 ug/ml calcineurin signaling inhibitor tacrolimus after 48 hrs by microdilution checkboard technique relative to control | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | In vitro interactions between tacrolimus and azoles against Candida albicans determined by different methods. |
| AID493520 | Antifungal activity against Trichosporon asahii 1188 after 48 hrs by broth microdilution assay | 2010 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 20, Issue:15 | N-Benzylsalicylthioamides as novel compounds with promising antimycotic activity. |
| AID1369509 | Disruption of cytoplasmic membrane electrical potential in Candida albicans cgmcc 2.2086 at MFC after 800 secs by DiSC3-5 dye-based fluorescence spectrophotometric method | 2018 | Journal of medicinal chemistry, 05-10, Volume: 61, Issue:9 | Combating Drug-Resistant Fungi with Novel Imperfectly Amphipathic Palindromic Peptides. |
| AID1754366 | Antifungal activity against Candida parapsilosis ATCC 22019 assessed as reduction in fungal growth incubated for 24 hrs by broth microdilution method based spectrophotometric analysis | 2021 | Bioorganic & medicinal chemistry, 07-01, Volume: 41 | Iodinated 1,2-diacylhydrazines, benzohydrazide-hydrazones and their analogues as dual antimicrobial and cytotoxic agents. |
| AID49637 | Minimum inhibitory concentration of compound for antifungal activity against Candida albicans 4 | 2000 | Bioorganic & medicinal chemistry letters, Oct-02, Volume: 10, Issue:19 | Novel antifungals based on 4-substituted imidazole: a combinatorial chemistry approach to lead discovery and optimization. |
| AID1658343 | Antifungal activity against fluconazole-resistant Candida albicans 904 assessed as reduction in fungal growth by NCCLS method | 2020 | ACS medicinal chemistry letters, Jun-11, Volume: 11, Issue:6 | Construction and Evaluation of Molecular Models: Guide and Design of Novel SE Inhibitors. |
| AID428613 | Antifungal activity against Candida albicans ATCC 10231 at 25 ug/disk after 24 hrs by disk diffusion method | 2009 | European journal of medicinal chemistry, Jul, Volume: 44, Issue:7 | Synthesis and biological evaluation of a novel series of 1,5-benzothiazepine derivatives as potential antimicrobial agents. |
| AID1155869 | Antifungal activity against Candida parapsilosis assessed as growth inhibition after 24 hrs by serial dilution method | 2014 | European journal of medicinal chemistry, Jul-23, Volume: 82 | Design, synthesis and antifungal activity of novel triazole derivatives containing substituted 1,2,3-triazole-piperdine side chains. |
| AID750759 | Antifungal activity against Trichoderma viride MTCC 1107 assessed as zone of inhibition at 40 uM after 48 hrs by disc diffusion method | 2013 | European journal of medicinal chemistry, Jun, Volume: 64 | Biological activity, design, synthesis and structure activity relationship of some novel derivatives of curcumin containing sulfonamides. |
| AID411179 | Ratio of MFC to MIC against Candida albicans ATCC 10231 | 2009 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 19, Issue:1 | One-pot synthesis of 5-phenylimino, 5-thieno or 5-oxo-1,2,3-dithiazoles and evaluation of their antimicrobial and antitumor activity. |
| AID1651345 | Antifungal activity against Candida parapsilosis 22019 by NCCLS protocol based broth microdilution assay | 2020 | Bioorganic & medicinal chemistry letters, 02-15, Volume: 30, Issue:4 | Design, synthesis, and structure-activity relationship studies of novel triazole agents with strong antifungal activity against Aspergillus fumigatus. |
| AID518447 | Antimicrobial activity against Cryptococcus gattii serotype B isolate RB14 assessed as heteroresistant isolates at 4 ug/ml | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Heteroresistance of Cryptococcus gattii to fluconazole. |
| AID1689831 | Inhibition of sterol biosynthesis in Candida albicans CAAL93 assessed as ergosterol level at 10 ng/ml after 18 hrs by GC-MS analysis (Rvb = 89.7%) | 2020 | European journal of medicinal chemistry, Mar-01, Volume: 189 | New azole antifungals with a fused triazinone scaffold. |
| AID715633 | Antifungal activity against Candida albicans MTCC 183 after 72 hrs by serial dilution method | 2012 | European journal of medicinal chemistry, Nov, Volume: 57 | Synthesis, characterization, biological evaluation and QSAR studies of 11-p-substituted phenyl-12-phenyl-11a,12-dihydro-11H-indeno[2,1-c][1,5]benzothiazepines as potential antimicrobial agents. |
| AID1439295 | Antifungal activity against Candida albicans after 24 hrs by serial dilution method | 2017 | European journal of medicinal chemistry, Mar-10, Volume: 128 | Tetrazolylmethyl quinolines: Design, docking studies, synthesis, anticancer and antifungal analyses. |
| AID1864966 | Immunostimulatory activity in mouse infected with Candida albicans ATCC SC5314 assessed as increase in CD8+ expression level in spleen in presence of naproxen by immunohistochemical analysis | |||
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| AID598232 | Antimicrobial activity against Candida tropicalis isolate 22 after 48 hrs by microdilution broth method | 2011 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 21, Issue:11 | Synthesis and in vitro antimicrobial activities of new (cyano-NNO-azoxy)pyrazole derivatives. |
| AID1348082 | Antimicrobial activity against Candida tropicalis ATCC 13803 assessed as zone of inhibition at 50 ug per disc after 48 hrs by disc diffusion assay | 2018 | European journal of medicinal chemistry, Jan-01, Volume: 143 | Synthesis of new 1-benzyl tetrahydropyridinylidene ammonium salts and their antimicrobial and anticellular activities. |
| AID719027 | Antifungal activity against Trichophyton mentagrophytes 445 assessed as growth inhibition after 72 hrs by CLSI M38-A broth microdilution method | 2012 | Bioorganic & medicinal chemistry, Dec-15, Volume: 20, Issue:24 | Anti-infective and herbicidal activity of N-substituted 2-aminobenzothiazoles. |
| AID262547 | Antifungal activity against Candida parapsilosis | 2006 | Journal of medicinal chemistry, Apr-20, Volume: 49, Issue:8 | Structure-based optimization of azole antifungal agents by CoMFA, CoMSIA, and molecular docking. |
| AID341134 | Antifungal activity against Saccharomycopsis guttulata isolates from feeding stuff by NCCLS M27-A2 method | 2007 | Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8 | Cross-resistance to medical and agricultural azole drugs in yeasts from the oropharynx of human immunodeficiency virus patients and from environmental Bavarian vine grapes. |
| AID772333 | Antifungal activity against wild type Candida parapsilosis ATCC 34136 after 24 hrs by visually and spectrophotometric analysis | 2013 | ACS medicinal chemistry letters, Sep-12, Volume: 4, Issue:9 | Novel Macrocyclic Amidinoureas: Potent Non-Azole Antifungals Active against Wild-Type and Resistant Candida Species. |
| AID1624188 | Antifungal activity against Cryptococcus neoformans NR-41295 after 24 hrs by microbroth dilution method | 2019 | Bioorganic & medicinal chemistry letters, 03-01, Volume: 29, Issue:5 | Benzimidazole tethered pyrrolo[3,4-b]quinoline with broad-spectrum activity against fungal pathogens. |
| AID1413341 | Antifungal activity against Fusarium graminearum B4-5A strain A after 48 hrs by microdilution assay | 2018 | MedChemComm, Jun-01, Volume: 9, Issue:6 | Antifungal amphiphilic kanamycins: new life for an old drug. |
| AID719028 | Antifungal activity against Trichosporon asahii 1188 assessed as growth inhibition after 48 hrs by CLSI M27-A2 broth microdilution method | 2012 | Bioorganic & medicinal chemistry, Dec-15, Volume: 20, Issue:24 | Anti-infective and herbicidal activity of N-substituted 2-aminobenzothiazoles. |
| AID751629 | Antifungal activity against Aspergillus flavus up to 24 hrs | 2013 | European journal of medicinal chemistry, Feb, Volume: 60 | Synthesis and antifungal activity of some s-mercaptotriazolobenzothiazolyl amino acid derivatives. |
| AID1783776 | Antifungal activity against Candida krusei GIM2.1 assessed as inhibition of fungal growth by NCCLS protocol based method | 2021 | European journal of medicinal chemistry, Nov-15, Volume: 224 | Improving the metabolic stability of antifungal compounds based on a scaffold hopping strategy: Design, synthesis, and structure-activity relationship studies of dihydrooxazole derivatives. |
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| AID603261 | Antifungal activity against Candida tropicalis clinical isolate by micro-broth dilution method | 2011 | European journal of medicinal chemistry, Jul, Volume: 46, Issue:7 | Design, synthesis and molecular docking studies of novel triazole as antifungal agent. |
| AID1484681 | Leishmanicidal activity against Leishmania donovani 1S MHOM/SD/00/1S-2D promastigote forms after 18 hrs by indirect microscopic analysis | 2017 | European journal of medicinal chemistry, Jul-28, Volume: 135 | An overview of azoles targeting sterol 14α-demethylase for antileishmanial therapy. |
| AID1242648 | Antifungal activity against Sporothrix schenckii after 16 hrs by microtiter broth dilution method | 2015 | ACS medicinal chemistry letters, Jul-09, Volume: 6, Issue:7 | Novel Chalcone-Thiazole Hybrids as Potent Inhibitors of Drug Resistant Staphylococcus aureus. |
| AID574603 | Antifungal activity against Trichosporon beigelii 1188 after 24 hrs by broth microdilution method | 2011 | Bioorganic & medicinal chemistry, Feb-15, Volume: 19, Issue:4 | Synthesis and antimycobacterial properties of N-substituted 6-amino-5-cyanopyrazine-2-carboxamides. |
| AID520620 | Antifungal activity against Candida metapsilosis by microdilution AFST-EUCAST method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Prevalence and susceptibility profile of Candida metapsilosis and Candida orthopsilosis: results from population-based surveillance of candidemia in Spain. |
| AID1472818 | Antifungal activity against itraconazole and fluconazole resistant Candida albicans ATCC MYA-1237 after 48 hrs by broth dilution method | 2018 | Journal of medicinal chemistry, 01-11, Volume: 61, Issue:1 | Alkylated Piperazines and Piperazine-Azole Hybrids as Antifungal Agents. |
| AID287834 | Antifungal activity against Trichophyton mentagrophytes 445 after 120 hrs | 2007 | Bioorganic & medicinal chemistry, Apr-15, Volume: 15, Issue:8 | Hybrid molecules of estrone: new compounds with potential antibacterial, antifungal, and antiproliferative activities. |
| AID477305 | Antifungal activity against Aspergillus flavus after 1 to 7 days by twofold serial dilution method | 2010 | European journal of medicinal chemistry, Apr, Volume: 45, Issue:4 | Synthesis and in vitro microbiological evaluation of an array of biolabile 2-morpholino-N-(4,6-diarylpyrimidin-2-yl)acetamides. |
| AID704465 | Antifungal activity against Candida glabrata CLY 574 after 24 hrs by NCCLS broth microdilution method | 2012 | ACS medicinal chemistry letters, Oct-11, Volume: 3, Issue:10 | Antifungal spectrum, in vivo efficacy, and structure-activity relationship of ilicicolin h. |
| AID1598014 | Antifungal activity against Trichophyton rubrum | 2019 | European journal of medicinal chemistry, May-15, Volume: 170 | Current advances of triazole alcohols derived from fluconazole: Design, in vitro and in silico studies. |
| AID365070 | Antifungal activity against Microsporum gypseum FF3 after 5 days by broth macrodilution method | 2008 | Bioorganic & medicinal chemistry, Sep-01, Volume: 16, Issue:17 | Antifungal activity of synthetic di(hetero)arylamines based on the benzo[b]thiophene moiety. |
| AID606218 | Antifungal activity against Fonsecaea compacta by micro-broth dilution method | 2011 | European journal of medicinal chemistry, Jul, Volume: 46, Issue:7 | Design, synthesis and antifungal activities of novel 1,2,4-triazole derivatives. |
| AID741612 | Antifungal activity against Aspergillus niger KCTC 1231 after 2 days by two fold broth dilution method | 2013 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 23, Issue:7 | Synthesis and antifungal evaluation of 7-arylamino-5,8-dioxo-5,8-dihydroisoquinoline-4-carboxylates. |
| AID1904393 | Cytotoxicity against human A549 cells assessed as reduction in cell viability incubated for 96 hrs by MTT assay | 2022 | European journal of medicinal chemistry, Apr-05, Volume: 233 | Design, synthesis, and evaluation of novel 3-thiophene derivatives as potent fungistatic and fungicidal reagents based on a conformational restriction strategy. |
| AID555596 | Antimicrobial activity against Cryptococcus albidus by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Activity profile in vitro of micafungin against Spanish clinical isolates of common and emerging species of yeasts and molds. |
| AID1413336 | Antifungal activity against sensitive Candida parapsilosis | 2018 | MedChemComm, Jun-01, Volume: 9, Issue:6 | Antifungal amphiphilic kanamycins: new life for an old drug. |
| AID1743173 | Antifungal activity against Candida albicans | 2020 | European journal of medicinal chemistry, Dec-15, Volume: 208 | Multiple biological active 4-aminopyrazoles containing trifluoromethyl and their 4-nitroso-precursors: Synthesis and evaluation. |
| AID655714 | Antifungal activity against Curvularia lunata MTCC 581 at 160 uM/ml after 48 hrs by paper disc diffusion method | 2012 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 22, Issue:8 | Design, synthesis, synergistic antimicrobial activity and cytotoxicity of 4-aryl substituted 3,4-dihydropyrimidinones of curcumin. |
| AID1758013 | Antifungal activity against fluconazole-resistant Candida albicans 904 assessed as inhibition of microbial growth after 24 hrs by broth microdilution method | 2021 | European journal of medicinal chemistry, Apr-15, Volume: 216 | Lead optimization generates selenium-containing miconazole CYP51 inhibitors with improved pharmacological profile for the treatment of fungal infections. |
| AID1864932 | Induction of mitochondrial membrane potential loss in Candida albicans ATCC SC5314 assessed as polarized cells at 1 umol/ml incubated for 24 hrs by JC-1 staining based flow cytometry assay (Rvb = 0.69%) | |||
| AID1728509 | Inhibition of CYP51 in Candida albicans ATCC SC5314 assessed as ergosterol level at 0.5 ug/ml incubated for 48 hrs by LC/MS analysis (Rvb = 95.1 %) | 2021 | European journal of medicinal chemistry, Jan-15, Volume: 210 | Novel naphthylamide derivatives as dual-target antifungal inhibitors: Design, synthesis and biological evaluation. |
| AID1156864 | Antimicrobial activity against Cryptococcus neoformans after 72 hrs by microbroth dilution method | 2014 | European journal of medicinal chemistry, Aug-18, Volume: 83 | Synthesis of 2,3,6-trideoxy sugar triazole hybrids as potential new broad spectrum antimicrobial agents. |
| AID1076848 | Antifungal activity against early stage preformed Candida albicans ATCC 10231 biofilm by XTT reduction assay | 2014 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 24, Issue:6 | Activity of caffeic acid derivatives against Candida albicans biofilm. |
| AID490939 | Antifungal activity against Penicillium chrysogenum NCIM 707 after 72 hrs by disc diffusion method | 2010 | European journal of medicinal chemistry, Jul, Volume: 45, Issue:7 | Synthesis and biological evaluation of a novel series of 2,2-bisaminomethylated aurone analogues as anti-inflammatory and antimicrobial agents. |
| AID405069 | Antifungal activity against Candida parapsilosis ATCC 22019 isolate from cutaneous-lymphatic sporotrichosis patient after 72 hrs by modified NCCLS M38-A method | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | In vitro susceptibility of Sporothrix schenckii to six antifungal agents determined using three different methods. |
| AID372242 | Fungistatic activity against Candida albicans SSK23 after 24 to 48 hrs by broth microdilution assay | 2007 | Antimicrobial agents and chemotherapy, Oct, Volume: 51, Issue:10 | The Ssk1p response regulator and Chk1p histidine kinase mutants of Candida albicans are hypersensitive to fluconazole and voriconazole. |
| AID1491266 | Inhibition of CYP51 in Candida albicans ATCC SC5314 assessed as eburicol content at 0.125 ug/ml by GS-MS analysis relative to total sterols (Rvb = 0.4%) | 2017 | European journal of medicinal chemistry, Sep-08, Volume: 137 | Design, synthesis and evaluation of aromatic heterocyclic derivatives as potent antifungal agents. |
| AID1728467 | Antifungal activity against Candida albicans ATCC SC5314 assessed as decrease in fungal cell density at 10 nM/mL by polarizing microscopy | 2021 | European journal of medicinal chemistry, Jan-15, Volume: 210 | Novel naphthylamide derivatives as dual-target antifungal inhibitors: Design, synthesis and biological evaluation. |
| AID416741 | Antifungal activity against Aspergillus niger MTCC 2425 by serial dilution method | 2009 | European journal of medicinal chemistry, Feb, Volume: 44, Issue:2 | Hansch analysis of veratric acid derivatives as antimicrobial agents. |
| AID527138 | Antifungal activity against Trichophyton mentagrophytes LMGO 1931 after 5 days microdilution technique | 2010 | Journal of natural products, Oct-22, Volume: 73, Issue:10 | Search for antifungal compounds from the wood of durable tropical trees. |
| AID1419476 | Antimicrobial activity against Bacillus cereus by two fold serial dilution method | 2017 | European journal of medicinal chemistry, May-05, Volume: 131 | Synthesis and biological evaluation of a new series of benzimidazole derivatives as antimicrobial, antiquorum-sensing and antitumor agents. |
| AID1125797 | Antifungal activity against Saccharomyces cerevisiae NCIM 3044 assessed as diameter of growth inhibition zone at 10 ug/ml after 4 days by agar disc diffusion method | 2014 | European journal of medicinal chemistry, Apr-22, Volume: 77 | New polyfunctional imidazo[4,5-C]pyridine motifs: synthesis, crystal studies, docking studies and antimicrobial evaluation. |
| AID1864946 | Inhibition of CYP51 in Candida albicans ATCC SC5314 assessed as unknown sterol level at 4 ug/ml incuabted for 48 hrs by GC-MS analysis (Rvb = 2.47%) | |||
| AID555015 | Antifungal against Candida utilis assessed as percent susceptible isolates at 25 ug/disc by CLSI M44-A disk diffusion method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | In vitro activities of fluconazole and voriconazole against clinical isolates of Candida spp. determined by disk diffusion testing in Turin, Italy. |
| AID555591 | Antimicrobial activity against Rhodotorula mucilaginosa by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Activity profile in vitro of micafungin against Spanish clinical isolates of common and emerging species of yeasts and molds. |
| AID598304 | Antimicrobial activity against Candida albicans ATCC 90028 after 48 hrs by microdilution broth method | 2011 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 21, Issue:11 | Synthesis and in vitro antimicrobial activities of new (cyano-NNO-azoxy)pyrazole derivatives. |
| AID1767308 | Antifungal activity against Aspergillus fumigatus assessed as fungal growth inhibition by CLSI protocol based microbroth dilution method | 2021 | European journal of medicinal chemistry, Oct-05, Volume: 221 | Discovery of novel purinylthiazolylethanone derivatives as anti-Candida albicans agents through possible multifaceted mechanisms. |
| AID294565 | Antimicrobial activity against Enterococcus hirae ATCC 10541 at 20 ug by disk diffusion method | 2007 | European journal of medicinal chemistry, Jun, Volume: 42, Issue:6 | Rapid synthesis of sulfone derivatives as potential anti-infectious agents. |
| AID405039 | Antifungal activity against Sporothrix schenckii P10012 isolate from cutaneous-lymphatic sporotrichosis patient after 72 hrs by modified NCCLS M38-A method | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | In vitro susceptibility of Sporothrix schenckii to six antifungal agents determined using three different methods. |
| AID530925 | Antifungal activity against Fluconazole resistant Candida albicans isolate 1 at 163.3 uM after 48 hrs by CLSI method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Potent in vitro antifungal activities of naturally occurring acetylenic acids. |
| AID525543 | Antimicrobial activity against Fonsecaea monophora isolates after 72 hrs by CLSI M38-A2 protocol method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | In vitro activities of eight antifungal drugs against 55 clinical isolates of Fonsecaea spp. |
| AID561634 | Antimicrobial activity against Burkholderia sp. at 8 to 32 ug/ml | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Heteroresistance to fluconazole in Cryptococcus neoformans is intrinsic and associated with virulence. |
| AID1168352 | Ratio of binding constant for human serum albumin in presence of La3+ to binding constant for human serum albumin in absence of metal ions | 2014 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 24, Issue:21 | Study the interactions between human serum albumin and two antifungal drugs: fluconazole and its analogue DTP. |
| AID1864889 | Antifungal activity against Cryptococcus neoformans ZKCC 2209 assessed as fungal growth inhibition measured after 72 hrs in presence of naproxen by double dilution method | |||
| AID1904372 | Inhibition of CYP51 in Candida albicans ATCC SC5314 assessed as lanosterol level at 0.25 ug/ml measured after 18 hrs by GC-MS analysis relative to control | 2022 | European journal of medicinal chemistry, Apr-05, Volume: 233 | Design, synthesis, and evaluation of novel 3-thiophene derivatives as potent fungistatic and fungicidal reagents based on a conformational restriction strategy. |
| AID549046 | Antifungal activity against Candida albicans CA3 after 48 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | In vitro activities of retigeric acid B alone and in combination with azole antifungal agents against Candida albicans. |
| AID1199856 | Inhibition of yeast histone acetyltransferase Gcn5-Ada2-Ada3 complex using tetramer and [3H]-acetyl-CoA assessed as acetate incorporation after 30 mins by liquid scintillation counting | 2015 | Journal of medicinal chemistry, Mar-12, Volume: 58, Issue:5 | PAINS in the assay: chemical mechanisms of assay interference and promiscuous enzymatic inhibition observed during a sulfhydryl-scavenging HTS. |
| AID257111 | Survival of mouse administered at 14 mg/kg/day, ip | 2005 | Journal of medicinal chemistry, Dec-01, Volume: 48, Issue:24 | Design, synthesis, and microbiological evaluation of new Candida albicans CYP51 inhibitors. |
| AID49119 | Compound was tested for antifungal activity against growth of three strains of Candida albicans | 2000 | Bioorganic & medicinal chemistry letters, Apr-17, Volume: 10, Issue:8 | Synthesis and antifungal activity of a ferrocene-fluconazole analogue. |
| AID128176 | Compound was tested for antifungal activity by measuring systemic candidosis in mice on 7th day upon single peroral administration | 1998 | Bioorganic & medicinal chemistry letters, Jul-21, Volume: 8, Issue:14 | Synthesis of novel antifungal agents (2). |
| AID117945 | In vivo evaluation of % survival rate after peroral administration on 3rd day at dose 1 mg/kg | 1995 | Journal of medicinal chemistry, Sep-29, Volume: 38, Issue:20 | Synthesis and antifungal activity of new azole derivatives containing an N-acylmorpholine ring. |
| AID1472626 | In vitro antifungal activity against Trichophyton mentagrophytes after 7 days by serial dilution method | 2018 | Journal of medicinal chemistry, 01-11, Volume: 61, Issue:1 | Novel Terminal Bipheny-Based Diapophytoene Desaturases (CrtN) Inhibitors as Anti-MRSA/VISR/LRSA Agents with Reduced hERG Activity. |
| AID301290 | Antifungal activity against Candida albicans ATCC 10453 after 48 hrs by broth micro dilution technique | 2007 | Bioorganic & medicinal chemistry, Nov-01, Volume: 15, Issue:21 | Synthesis of disulfide esters of dialkylaminocarbothioic acid as potent, non-detergent spermicidal agents. |
| AID1491242 | Antifungal activity against Candida albicans ATCC SC5314 by broth microdilution method | 2017 | European journal of medicinal chemistry, Sep-08, Volume: 137 | Design, synthesis and evaluation of aromatic heterocyclic derivatives as potent antifungal agents. |
| AID1904357 | Antifungal activity against Candida albicans CPCC400616 assessed as fungal growth inhibition by CLSI based serial microbroth dilution method | 2022 | European journal of medicinal chemistry, Apr-05, Volume: 233 | Design, synthesis, and evaluation of novel 3-thiophene derivatives as potent fungistatic and fungicidal reagents based on a conformational restriction strategy. |
| AID425145 | Antimicrobial activity against azole-resistant Candida albicans isolate CA10 assessed as growth at 32 ug/ml after 48 hrs by microdilution checkerboard technique relative to control | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | In vitro interactions between tacrolimus and azoles against Candida albicans determined by different methods. |
| AID1867444 | Induction of ROS generation in fluconazole resistant Saccharomyces cerevisiae overexpressing CgCdr2p transporter assessed as increase in ROS level incubated for 90 mins by DCFH-DA dye based fluorescence assay | 2022 | Bioorganic & medicinal chemistry, 06-01, Volume: 63 | Effects of β-lapachone and β-nor-lapachone on multidrug efflux transporters and biofilms of Candida glabrata. |
| AID572699 | Binding affinity to Mycobacterium tuberculosis CYP51 | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Identification, characterization, and azole-binding properties of Mycobacterium smegmatis CYP164A2, a homolog of ML2088, the sole cytochrome P450 gene of Mycobacterium leprae. |
| AID766639 | Antifungal activity against Issatchenkia hanoiensis MTCC 4755 after 24 hrs by well diffusion method | 2013 | European journal of medicinal chemistry, Sep, Volume: 67 | Total synthesis and biological evaluation of clavaminol-G and its analogs. |
| AID564272 | Antifungal activity against Candida albicans isolate 108 harboring erg11 and erg5 double mutant after 48 hrs by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | A clinical isolate of Candida albicans with mutations in ERG11 (encoding sterol 14alpha-demethylase) and ERG5 (encoding C22 desaturase) is cross resistant to azoles and amphotericin B. |
| AID613714 | Antifungal activity against Candida glabrata ATCC 90030 by broth dilution method | 2011 | Bioorganic & medicinal chemistry letters, Aug-15, Volume: 21, Issue:16 | Novel hybrids of fluconazole and furanones: design, synthesis and antifungal activity. |
| AID340953 | Antifungal activity against Candida glabrata isolates from feeding stuffs by NCCLS M27-A2 method | 2007 | Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8 | Cross-resistance to medical and agricultural azole drugs in yeasts from the oropharynx of human immunodeficiency virus patients and from environmental Bavarian vine grapes. |
| AID434898 | Antifungal activity against Candida tropicalis isolate 15 in RPMI 1640 medium by broth dilution susceptibility test | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | In vitro study of Candida tropicalis isolates exhibiting paradoxical growth in the presence of high concentrations of caspofungin. |
| AID459755 | Antifungal activity against Microsporum gypseum by serial dilution method | 2010 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 20, Issue:3 | Synthesis and antifungal activities in vitro of novel pyrazino [2,1-a] isoquinolin derivatives. |
| AID521496 | Antifungal activity against Candida dubliniensis ATCC MYA-577 after 48 hrs by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | In vitro and in vivo antifungal activities of T-2307, a novel arylamidine. |
| AID532571 | Antifungal activity against Candida glabrata isolate 21230 with silent mutations in ERG4, ERG5 genes and nonsense mutation in ERG6 gene by disk diffusion method | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | A nonsense mutation in the ERG6 gene leads to reduced susceptibility to polyenes in a clinical isolate of Candida glabrata. |
| AID1610306 | Antifungal activity against Candida albicans SC5314 incubated for 24 hrs by CLSI protocol based microbroth dilution method | 2019 | Bioorganic & medicinal chemistry letters, 12-01, Volume: 29, Issue:23 | Design, synthesis and biological evaluation of novel semicarbazone-selenochroman-4-ones hybrids as potent antifungal agents. |
| AID519055 | Antifungal activity against Penicillium sp. after 48 hrs by broth microdilution | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | Antimicrobial activity of omiganan pentahydrochloride against contemporary fungal pathogens responsible for catheter-associated infections. |
| AID1736722 | Antifungal activity against Candida parapsilosis ATCC 22019 assessed as reduction in fungal growth incubated for 48 hrs by broth microdilution assay | 2020 | European journal of medicinal chemistry, Mar-15, Volume: 190 | 4-Substituted picolinohydrazonamides as a new class of potential antitubercular agents. |
| AID1759448 | Cytotoxicity against human HEK293 cells assessed as cell survival at 0.25 times MIC incubated for 24 hrs by MTT assay | 2021 | Bioorganic & medicinal chemistry letters, 06-01, Volume: 41 | Inhibitory effects and mechanism of antifungal action of the natural cyclic depsipeptide, aureobasidin A against Cryptococcus neoformans. |
| AID555590 | Antimicrobial activity against Trichosporon asahii by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Activity profile in vitro of micafungin against Spanish clinical isolates of common and emerging species of yeasts and molds. |
| AID294849 | Antifungal activity against Candida parapsilosis ATCC 0306392 after 7 days by micro-broth dilution method | 2007 | European journal of medicinal chemistry, Sep, Volume: 42, Issue:9 | Synthesis of novel triazole derivatives as inhibitors of cytochrome P450 14alpha-demethylase (CYP51). |
| AID1190605 | Antimicrobial activity against Staphylococcus aureus ATCC 25923 assessed as inhibition of microbial growth incubated for 24 hrs by broth dilution method | 2015 | Bioorganic & medicinal chemistry letters, Feb-15, Volume: 25, Issue:4 | Synthesis, antimicrobial activity and molecular docking of novel tetracyclic scaffolds incorporating a flavonoid framework with medium sized oxygen heterocycles. |
| AID1770935 | Anti-biofilm activity in Candida albicans CPCC400616 assessed as inhibition of biofilm formation incubated for 6 hrs by XTT assay | 2021 | European journal of medicinal chemistry, Dec-05, Volume: 225 | Design, synthesis and evaluation of novel 5-phenylthiophene derivatives as potent fungicidal of Candida albicans and antifungal reagents of fluconazole-resistant fungi. |
| AID440312 | Anticandidal activity against Candida krusei ATCC 14243 after 24 hrs by spectrophotometry | 2009 | Journal of medicinal chemistry, Dec-10, Volume: 52, Issue:23 | Synthesis of new linear guanidines and macrocyclic amidinourea derivatives endowed with high antifungal activity against Candida spp. and Aspergillus spp. |
| AID581897 | Antifungal activity against Candida glabrata isolated from neutropenic subject 1331 with AML or MDS pharynx receiving antifungal drug after 21 days prophylaxis by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Impact of antifungal prophylaxis on colonization and azole susceptibility of Candida species. |
| AID532532 | Antifungal activity against Saccharomyces cerevisiae BY4741 harboring human CYP51 assessed as accumulation of 14-alpha-methylergosta-8,24(28)-dien-3beta-6alpha-diol at 16 ug/ml | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | Differential azole antifungal efficacies contrasted using a Saccharomyces cerevisiae strain humanized for sterol 14 alpha-demethylase at the homologous locus. |
| AID1898162 | Antifungal activity against Candida albicans 14# | |||
| AID1063950 | Antifungal activity against Trichosporon asahii 1188 after 24 hrs by broth microdilution method | 2014 | Bioorganic & medicinal chemistry, Jan-15, Volume: 22, Issue:2 | Salicylanilide diethyl phosphates: synthesis, antimicrobial activity and cytotoxicity. |
| AID584387 | Antifungal activity against 36 days cultured Candida glabrata isolated from neutropenic subject with AML or MDS pharynx after 48 days of prophylaxis by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Impact of antifungal prophylaxis on colonization and azole susceptibility of Candida species. |
| AID588212 | Literature-mined compound from Fourches et al multi-species drug-induced liver injury (DILI) dataset, effect in rodents | 2010 | Chemical research in toxicology, Jan, Volume: 23, Issue:1 | Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. |
| AID598302 | Antimicrobial activity against Cryptococcus neoformans var. neoformans isolate 30 after 48 hrs by microdilution broth method | 2011 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 21, Issue:11 | Synthesis and in vitro antimicrobial activities of new (cyano-NNO-azoxy)pyrazole derivatives. |
| AID386929 | Antifungal activity against Candida albicans MTCC 1346 after 48 hrs by broth microdilution technique | 2008 | European journal of medicinal chemistry, Oct, Volume: 43, Issue:10 | Carbodithioic acid esters of fluoxetine, a novel class of dual-function spermicides. |
| AID1168334 | Binding affinity to human serum albumin by spectroscopy in presence of Ba2+ | 2014 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 24, Issue:21 | Study the interactions between human serum albumin and two antifungal drugs: fluconazole and its analogue DTP. |
| AID521512 | Antifungal activity against Aspergillus fumigatus TIMM 0063 after 48 hrs by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | In vitro and in vivo antifungal activities of T-2307, a novel arylamidine. |
| AID1274472 | Antifungal activity against Candida albicans CMCC 76615 after 24 hrs by two-fold serial dilution method | 2016 | European journal of medicinal chemistry, Jan-27, Volume: 108 | Synthesis and biological evaluation of novel phosphoramidate derivatives of coumarin as chitin synthase inhibitors and antifungal agents. |
| AID1758040 | Inhibition of CYP51 in Candida albicans ATCC SC5314 assessed as lanosterol level at 8 ug/ml after 16 hrs by GC-MS analysis (Rvb = 1.7%) | 2021 | European journal of medicinal chemistry, Apr-15, Volume: 216 | Lead optimization generates selenium-containing miconazole CYP51 inhibitors with improved pharmacological profile for the treatment of fungal infections. |
| AID372229 | Effect on CDR11 RNA level in Candida albicans SSK21 at MIC after 120 mins by RT-PCR | 2007 | Antimicrobial agents and chemotherapy, Oct, Volume: 51, Issue:10 | The Ssk1p response regulator and Chk1p histidine kinase mutants of Candida albicans are hypersensitive to fluconazole and voriconazole. |
| AID468461 | Antifungal activity against Candida albicans after 16 to 18 hrs by serial dilution method | 2010 | European journal of medicinal chemistry, Feb, Volume: 45, Issue:2 | Synthesis, characterization and biological activities of some new benzo[b]thiophene derivatives. |
| AID572696 | Binding affinity to Mycobacterium smegmatis ATCC 700084 CYP164A2 in presence of 0.5 M NaCl at pH7.5 | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Identification, characterization, and azole-binding properties of Mycobacterium smegmatis CYP164A2, a homolog of ML2088, the sole cytochrome P450 gene of Mycobacterium leprae. |
| AID499664 | Antimicrobial activity against Candida krusei TIMM 0269 by microdilution assay | 2010 | Bioorganic & medicinal chemistry, Aug-15, Volume: 18, Issue:16 | Novel antifungal agents: triazolopyridines as inhibitors of beta-1,6-glucan synthesis. |
| AID561426 | Antifungal activity against Candida lusitaniae CL38-5 expressing FCY21 gene by microdilution method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Nonsense and missense mutations in FCY2 and FCY1 genes are responsible for flucytosine resistance and flucytosine-fluconazole cross-resistance in clinical isolates of Candida lusitaniae. |
| AID279702 | Antifungal activity against planktonic Candida albicans K1 | 2007 | Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2 | Putative role of beta-1,3 glucans in Candida albicans biofilm resistance. |
| AID1246592 | Antifungal activity against Cryptococcus neoformans LMM820 after 48 to 72 hrs by broth microdilution method | 2015 | European journal of medicinal chemistry, Sep-18, Volume: 102 | Thiazole compounds with activity against Cryptococcus gattii and Cryptococcus neoformans in vitro. |
| AID1320773 | Antifungal activity against Fusarium sambucinum MF1 assessed as radial growth inhibition at 32 ug/ml after 5 to 7 days relative to control | 2016 | Bioorganic & medicinal chemistry, 11-15, Volume: 24, Issue:22 | Synthesis of novel tetrazole derivatives and evaluation of their antifungal activity. |
| AID1556227 | Inhibition of CYP51 in Candida albicans ATCC SC5314 assessed as eburicol level at 0.13 ug/ml incubated for 16 hrs by GC/MS analysis (Rvb = 0%) | 2019 | European journal of medicinal chemistry, Sep-01, Volume: 177 | Design, synthesis, and structure-activity relationship studies of l-amino alcohol derivatives as broad-spectrum antifungal agents. |
| AID1898154 | Antifungal activity against Candida parapsilosis 22019 | |||
| AID1361021 | Antifungal activity against Aspergillus niger MTCC 9933 after 72 hrs | 2018 | European journal of medicinal chemistry, Jul-15, Volume: 155 | Rational modification of a lead molecule: Improving the antifungal activity of indole - triazole - amino acid conjugates. |
| AID1890303 | Antifungal activity against Mucor circinelloides R7B wild type strain assessed as complete absence of mycelia at 100 to 150 ug/ml by microscopic analysis | 2022 | Bioorganic & medicinal chemistry letters, 05-01, Volume: 63 | Novel 2-aryl-4-aryloxyquinoline-based fungistatics for Mucor circinelloides. Biological evaluation of activity, QSAR and docking study. |
| AID406859 | Antimicrobial activity against Candida albicans SC5314 at planktonic cell density of 10'8 cells/ml after 48 hrs by XTT assay | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | Role for cell density in antifungal drug resistance in Candida albicans biofilms. |
| AID1762156 | Antifungal activity against Candida albicans 604M assessed as reduction in fungal growth incubated for 24 hrs by CLSI based serial microbroth dilution method | 2021 | Bioorganic & medicinal chemistry letters, 05-15, Volume: 40 | Synthesis and antifungal activity of new hybrids thiazolo[4,5-d]pyrimidines with (1H-1,2,4)triazole. |
| AID424913 | Antimicrobial activity against azole-resistant Candida albicans isolate CA10 assessed as growth at 1 ug/ml cotreated with 0.004 ug/ml calcineurin signaling inhibitor Tacrolimus after 48 hrs by microdilution checkboard technique relative to control | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | In vitro interactions between tacrolimus and azoles against Candida albicans determined by different methods. |
| AID521969 | Antibacterial activity against Fluconazole resistant Candida albicans DSY3608 containing tac1delta/delta ERG11-1/ERG11-1 (TAC1-1) genotype by EUCAST standards based broth microdilution method sCandida albicans DSY294 | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Genetic dissection of azole resistance mechanisms in Candida albicans and their validation in a mouse model of disseminated infection. |
| AID555005 | Antifungal activity against Candida kefyr assessed as percent resistant isolates at 25 ug/disc by CLSI M44-A disk diffusion method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | In vitro activities of fluconazole and voriconazole against clinical isolates of Candida spp. determined by disk diffusion testing in Turin, Italy. |
| AID279114 | Antimicrobial activity against Candida albicans at 48 hrs | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Association of fluconazole area under the concentration-time curve/MIC and dose/MIC ratios with mortality in nonneutropenic patients with candidemia. |
| AID1891821 | Antifungal activity against Cryptococcus neoformans ATCC 208821 assessed as fungal growth inhibition incubated for 36 hrs by resazurin dye based analysis | 2022 | Bioorganic & medicinal chemistry, 06-15, Volume: 64 | Valorisation of the diterpene podocarpic acid - Antibiotic and antibiotic enhancing activities of polyamine conjugates. |
| AID269982 | Antifungal activity against Candida glabrata 578 | 2006 | Journal of medicinal chemistry, Aug-10, Volume: 49, Issue:16 | Synthesis and antifungal activity of a novel series of alkyldimethylamine cyanoboranes and their derivatives. |
| AID43430 | Compound was tested for the inhibition beta-lactamase with 0.1 mg/ml saponin:No inhibition | 2003 | Journal of medicinal chemistry, Oct-09, Volume: 46, Issue:21 | Identification and prediction of promiscuous aggregating inhibitors among known drugs. |
| AID521987 | Antibacterial activity against Fluconazole resistant Candida albicans DSY3706 containing tac1delta/delta ERG11-1/ERG11-1 genotype infected in BALB/c mouse assessed as reduction in kidney microbial burden administered intraperitoneally 1 hr post bacterial | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Genetic dissection of azole resistance mechanisms in Candida albicans and their validation in a mouse model of disseminated infection. |
| AID329024 | Antifungal activity against Candida albicans ATCC 10231 at 25 ug/disc after 24 hrs by disc diffusion assay | 2008 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 18, Issue:8 | Synthesis and antimicrobial properties of monensin A esters. |
| AID1487223 | Inhibition of CYP17 lyase in human hepatocyte microsomes using 17a-hydroxypregnenolone substrate by HPLC/MS/MS method | 2017 | Bioorganic & medicinal chemistry letters, 08-01, Volume: 27, Issue:15 | Design and optimization of highly-selective, broad spectrum fungal CYP51 inhibitors. |
| AID47255 | Compound was tested for in vitro antifungal activity against Candida albicans (CY3003) | 1998 | Bioorganic & medicinal chemistry letters, Jul-21, Volume: 8, Issue:14 | Synthesis of novel antifungal agents (2). |
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| AID623052 | Antifungal activity against Aspergillus fumigatus 231 after 24 hrs by microdilution method | 2011 | Bioorganic & medicinal chemistry letters, Oct-15, Volume: 21, Issue:20 | Synthesis and biological activity of desmethoxy analogues of coruscanone A. |
| AID405095 | Antimicrobial activity against Rhizopus microsporus var. rhizopodiformis after 24 hrs | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | In vitro susceptibilities of 217 clinical isolates of zygomycetes to conventional and new antifungal agents. |
| AID407062 | Inhibition of metabolic activity in Candida albicans SC5314 at 32 ug/ml | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | Role for cell density in antifungal drug resistance in Candida albicans biofilms. |
| AID1742126 | Antifungal activity against Candida albicans assessed as inhibition of microbial growth by two fold broth microdilution method | 2020 | European journal of medicinal chemistry, Nov-01, Volume: 205 | Design, synthesis and bioactivity evaluation of novel arylalkene-amide derivatives as dual-target antifungal inhibitors. |
| AID1877300 | Inhibition of CYP51 in Candida albicans SC3514 assessed as decrease in ergosterol biosynthesis by measuring 14alpha-methyl ergosta-8,24(28)-dien-3beta,6alpha-diol level at 0.25 ug/ml incubated for 16 hrs by GC-MS analysis relative to total sterols | 2022 | European journal of medicinal chemistry, Jan-05, Volume: 227 | Broadening antifungal spectrum and improving metabolic stablity based on a scaffold strategy: Design, synthesis, and evaluation of novel 4-phenyl-4,5-dihydrooxazole derivatives as potent fungistatic and fungicidal reagents. |
| AID750172 | Antifungal activity against Aspergillus fumigatus after 7 days by NCCLS method | 2013 | European journal of medicinal chemistry, Jun, Volume: 64 | Discovery of highly potent triazole antifungal derivatives by heterocycle-benzene bioisosteric replacement. |
| AID1864938 | Induction of apoptosis in Candida albicans ATCC SC5314 assessed as necrotic cells incuabted for 24 hrs by V-FITC/PI staining based flow cytometry analysis (Rvb = 1.77%) | |||
| AID1235458 | Antifungal activity against Candida tropicalis ATCC 750 after 48 hrs by disc diffusion assay | 2015 | Bioorganic & medicinal chemistry, Aug-01, Volume: 23, Issue:15 | Imidazole clubbed 1,3,4-oxadiazole derivatives as potential antifungal agents. |
| AID1556541 | Antifungal activity against Candida parapsilosis ATCC 20019 assessed as reduction in fungal cell viability incubated for 24 hrs by two fold serial dilution method | 2019 | European journal of medicinal chemistry, Oct-01, Volume: 179 | A new exploration towards aminothiazolquinolone oximes as potentially multi-targeting antibacterial agents: Design, synthesis and evaluation acting on microbes, DNA, HSA and topoisomerase IV. |
| AID269984 | Antifungal activity against Candida glabrata 648 | 2006 | Journal of medicinal chemistry, Aug-10, Volume: 49, Issue:16 | Synthesis and antifungal activity of a novel series of alkyldimethylamine cyanoboranes and their derivatives. |
| AID561430 | Antifungal activity against Candida lusitaniae CL32 by microdilution method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Nonsense and missense mutations in FCY2 and FCY1 genes are responsible for flucytosine resistance and flucytosine-fluconazole cross-resistance in clinical isolates of Candida lusitaniae. |
| AID1369451 | Antifungal activity against Candida albicans 14936 after 48 hrs by broth microdilution method | 2018 | Journal of medicinal chemistry, 05-10, Volume: 61, Issue:9 | Combating Drug-Resistant Fungi with Novel Imperfectly Amphipathic Palindromic Peptides. |
| AID1762161 | Antifungal activity against Candida krusei 432M assessed as reduction in fungal growth incubated for 48 hrs by CLSI based serial microbroth dilution method | 2021 | Bioorganic & medicinal chemistry letters, 05-15, Volume: 40 | Synthesis and antifungal activity of new hybrids thiazolo[4,5-d]pyrimidines with (1H-1,2,4)triazole. |
| AID405053 | Antifungal activity against Sporothrix schenckii PGAC0016 isolate from cutaneous-lymphatic sporotrichosis patient after 72 hrs by ATB Fungus 2 method | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | In vitro susceptibility of Sporothrix schenckii to six antifungal agents determined using three different methods. |
| AID440310 | Anticandidal activity against Candida albicans 53T after 24 hrs by spectrophotometry | 2009 | Journal of medicinal chemistry, Dec-10, Volume: 52, Issue:23 | Synthesis of new linear guanidines and macrocyclic amidinourea derivatives endowed with high antifungal activity against Candida spp. and Aspergillus spp. |
| AID574610 | Antifungal activity against Candida krusei E28 after 48 hrs by broth microdilution method | 2011 | Bioorganic & medicinal chemistry, Feb-15, Volume: 19, Issue:4 | Synthesis and antimycobacterial properties of N-substituted 6-amino-5-cyanopyrazine-2-carboxamides. |
| AID521494 | Antifungal activity against Candida albicans ATCC 90028 after 48 hrs by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | In vitro and in vivo antifungal activities of T-2307, a novel arylamidine. |
| AID777332 | Antifungal activity against Cryptococcus neoformans CDRI isolate assessed as growth inhibition after 24 to 48 hrs by microbroth dilution method | 2013 | ACS medicinal chemistry letters, Oct-10, Volume: 4, Issue:10 | Identification of 1-[4-Benzyloxyphenyl)-but-3-enyl]-1H-azoles as New Class of Antitubercular and Antimicrobial Agents. |
| AID1681019 | Antifungal activity against Saccharomyces cerevisiae assessed as diameter of inhibition zone at 1 mg/ml incubated for 24 hrs by agar well diffusion assay | 2020 | Bioorganic & medicinal chemistry letters, 10-01, Volume: 30, Issue:19 | Novel isoniazid embedded triazole derivatives: Synthesis, antitubercular and antimicrobial activity evaluation. |
| AID670553 | Antifungal activity against Candida albicans MTCC 183 after 24 hrs by well diffusion method | 2012 | Bioorganic & medicinal chemistry letters, Jul-15, Volume: 22, Issue:14 | Total synthesis and antifungal activity of (2S,3R)-2-aminododecan-3-ol. |
| AID1075994 | Antifungal activity against Aspergillus niger NCIM 1196 by standard agar method | 2014 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 24, Issue:6 | Synthesis, antileishmanial activity and docking study of N'-substitutedbenzylidene-2-(6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)acetohydrazides. |
| AID1759431 | Inhibition of ergosterol biosynthesis in Cryptococcus neoformans PFCC 93-589 cell membrane assessed as ergosterol content at 1 times MIC incubated for 48 hrs by UV-visible spectrophotometric analysis (Rvb = 0.134 No_unit) | 2021 | Bioorganic & medicinal chemistry letters, 06-01, Volume: 41 | Inhibitory effects and mechanism of antifungal action of the natural cyclic depsipeptide, aureobasidin A against Cryptococcus neoformans. |
| AID521502 | Antifungal activity against Cryptococcus neoformans ATCC 90112 after 72 hrs by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | In vitro and in vivo antifungal activities of T-2307, a novel arylamidine. |
| AID1905253 | Synergistic antifungal activity against fluconazole-resistant Candida albicans 904 assessed as inhibition of fungal growth in presence of fluconazole by checker board microdilution assay | 2022 | Journal of medicinal chemistry, 04-14, Volume: 65, Issue:7 | Species-Selective Targeting of Fungal Hsp90: Design, Synthesis, and Evaluation of Novel 4,5-Diarylisoxazole Derivatives for the Combination Treatment of Azole-Resistant Candidiasis. |
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| AID1556226 | Inhibition of CYP51 in Candida albicans ATCC SC5314 assessed as lanosterol level at 8 ug/ml incubated for 16 hrs by GC/MS analysis (Rvb = 0%) | 2019 | European journal of medicinal chemistry, Sep-01, Volume: 177 | Design, synthesis, and structure-activity relationship studies of l-amino alcohol derivatives as broad-spectrum antifungal agents. |
| AID340956 | Antifungal activity against Candida krusei ATCC 6258 by NCCLS M27-A2 method | 2007 | Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8 | Cross-resistance to medical and agricultural azole drugs in yeasts from the oropharynx of human immunodeficiency virus patients and from environmental Bavarian vine grapes. |
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| AID1759445 | Hemolytic activity in human RBC at 1 ug/ml incubated for 30 mins | 2021 | Bioorganic & medicinal chemistry letters, 06-01, Volume: 41 | Inhibitory effects and mechanism of antifungal action of the natural cyclic depsipeptide, aureobasidin A against Cryptococcus neoformans. |
| AID1825527 | Anti-Cryptococcal activity against Cryptococcus neoformans infected pneumonia and encephalitis C57BL/6J mouse model assessed as improvement in clinical symptoms at 8 mg/kg, iv administered once a day for 9 days | 2022 | Journal of medicinal chemistry, 02-10, Volume: 65, Issue:3 | Synthesis of Hemiprotonic Phenanthroline-Phenanthroline |
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| AID1401694 | Antifungal against Candida mycoderma after 24 hrs by two fold serial dilution method | 2018 | European journal of medicinal chemistry, Jan-01, Volume: 143 | Novel aminopyrimidinyl benzimidazoles as potentially antimicrobial agents: Design, synthesis and biological evaluation. |
| AID1624181 | Antifungal activity against Candida albicans NR-29444 after 24 hrs by microbroth dilution method | 2019 | Bioorganic & medicinal chemistry letters, 03-01, Volume: 29, Issue:5 | Benzimidazole tethered pyrrolo[3,4-b]quinoline with broad-spectrum activity against fungal pathogens. |
| AID1369444 | Antifungal activity against Candida albicans SP3931 after 48 hrs by broth microdilution method | 2018 | Journal of medicinal chemistry, 05-10, Volume: 61, Issue:9 | Combating Drug-Resistant Fungi with Novel Imperfectly Amphipathic Palindromic Peptides. |
| AID405106 | Antimicrobial activity against Rhizopus microsporus var. microsporus assessed as percent of susceptible isolates after 24 hrs | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | In vitro susceptibilities of 217 clinical isolates of zygomycetes to conventional and new antifungal agents. |
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| AID1885961 | Antifungal activity against Candida krusei ATCC2340 assessed as fungal growth inhibition incubated for 48 hrs by broth microdilution method | |||
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| AID1602367 | Antifungal activity against Candida albicans 0304103 after 48 hrs by spectrophotometery | 2019 | Journal of medicinal chemistry, 03-14, Volume: 62, Issue:5 | Discovery of Carboline Derivatives as Potent Antifungal Agents for the Treatment of Cryptococcal Meningitis. |
| AID310100 | Antifungal activity against Aspergillus fumigatus by disc diffusion method | 2007 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 17, Issue:22 | Synthesis and antimicrobial activity of some novel nucleoside analogues of adenosine and 1,3-dideazaadenosine. |
| AID530947 | Antifungal activity against Trichophyton rubrum ATCC MYA-4438 by CLSI method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Potent in vitro antifungal activities of naturally occurring acetylenic acids. |
| AID530983 | Antifungal activity against Aspergillus niger ATCC 16404 at 163.3 uM after 48 hrs by CLSI method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Potent in vitro antifungal activities of naturally occurring acetylenic acids. |
| AID47096 | In vivo effective dose for antifungal activity on sc administration in female mice infected with 2.5*10e6 cells/mL of Candida albicans at day 14 | 2001 | Bioorganic & medicinal chemistry letters, Feb-12, Volume: 11, Issue:3 | FR131535, a novel water-soluble echinocandin-like lipopeptide: synthesis and biological properties. |
| AID1728512 | Inhibition of CYP51 in Candida albicans ATCC SC5314 assessed as lanosterol level at 0.125 ug/ml incubated for 48 hrs by LC/MS analysis | 2021 | European journal of medicinal chemistry, Jan-15, Volume: 210 | Novel naphthylamide derivatives as dual-target antifungal inhibitors: Design, synthesis and biological evaluation. |
| AID471343 | Antifungal activity against Candida albicans ATCC 10231 at 25 ug/disk after 48 hrs by paper disk method | 2009 | Journal of natural products, Sep, Volume: 72, Issue:9 | Spirobisnaphthalene analogues from the endophytic fungus Preussia sp. |
| AID47864 | Evaluation of In vitro antifungal activity against Candida parapsilosis 2.07 by broth macro dilution method | 1995 | Journal of medicinal chemistry, Sep-29, Volume: 38, Issue:20 | Synthesis and antifungal activity of new azole derivatives containing an N-acylmorpholine ring. |
| AID1418533 | Antifungal activity against Aspergillus fumigatus cgmcc 3.7795 after 2 to 7 days by broth microdilution method | 2018 | Bioorganic & medicinal chemistry letters, 12-01, Volume: 28, Issue:22 | Design, synthesis, and biological evaluation of 4-chloro-2H-thiochromenes featuring nitrogen-containing side chains as potent antifungal agents. |
| AID1758010 | Antifungal activity against fluconazole-resistant Candida albicans 17# assessed as inhibition of microbial growth after 24 hrs by broth microdilution method | 2021 | European journal of medicinal chemistry, Apr-15, Volume: 216 | Lead optimization generates selenium-containing miconazole CYP51 inhibitors with improved pharmacological profile for the treatment of fungal infections. |
| AID1700247 | Antifungal activity against Candida albicans ATCC 7754 | 2020 | Bioorganic & medicinal chemistry letters, 12-15, Volume: 30, Issue:24 | Synthesis and biological screening of thiosemicarbazones of substituted 3-acetylcoumarins having d-glucose moiety. |
| AID462227 | Antifungal activity against pharmacoresistant Candida albicans AIDS68 infected in Wistar rat estrogen-dependent fungal vaginitis model assessed as fungal burden at 10 ug administered intravaginally 1 hr after fungal infection measured within 1 day of infe | 2010 | Journal of medicinal chemistry, Mar-25, Volume: 53, Issue:6 | Identification of inhibitors of drug-resistant Candida albicans strains from a library of bicyclic peptidomimetic compounds. |
| AID619595 | Antifungal activity against Candida tropicalis after 24 hrs by broth microdilution method | 2011 | Bioorganic & medicinal chemistry, Oct-01, Volume: 19, Issue:19 | Antifungal activity of a series of 1,2-benzisothiazol-3(2H)-one derivatives. |
| AID1584734 | Drug metabolism in mouse liver microsome S9 fraction assessed as CYP450-mediated metabolism by measuring compound remaining at 5 uM pretreated with NADPH and measured after 15 mins by UPLC-MS/MS analysis | 2018 | Journal of medicinal chemistry, 10-25, Volume: 61, Issue:20 | Discovery of Novel 7-Aryl 7-Deazapurine 3'-Deoxy-ribofuranosyl Nucleosides with Potent Activity against Trypanosoma cruzi. |
| AID569441 | Antifungal activity against Penicillium species at 1000 ug after 24 hrs by paper disc technique | 2011 | European journal of medicinal chemistry, Feb, Volume: 46, Issue:2 | Efficient and novel one-pot synthesis of antifungal active 1-substituted-8-aryl-3-alkyl/aryl-4H-pyrazolo[4,5-f][1,2,4]triazolo[4,3-b][1,2,4]triazepines using solid support. |
| AID279121 | Ratio of weight normalized daily dose in surviving candidemia patient to MIC at 48 hrs against Candida species | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Association of fluconazole area under the concentration-time curve/MIC and dose/MIC ratios with mortality in nonneutropenic patients with candidemia. |
| AID245920 | Cytotoxicity to reduce human histolytic lymphoma U937 cells | 2004 | Journal of medicinal chemistry, Jul-29, Volume: 47, Issue:16 | Imidazole analogues of fluoxetine, a novel class of anti-Candida agents. |
| AID1162143 | Antifungal activity against Saccharomyces cerevisiae after 24 hrs by microbroth dilution method | 2014 | European journal of medicinal chemistry, Oct-30, Volume: 86 | Novel hybrids of metronidazole and quinolones: synthesis, bioactive evaluation, cytotoxicity, preliminary antimicrobial mechanism and effect of metal ions on their transportation by human serum albumin. |
| AID440765 | Antifungal activity against Fusarium oxysporum assessed as zone of inhibition diameter at 1 mg/mL after 48 hrs by twofold serial dilution method | 2009 | European journal of medicinal chemistry, Dec, Volume: 44, Issue:12 | Enaminonitrile in heterocyclic synthesis: synthesis and antimicrobial evaluation of some new pyrazole, isoxazole and pyrimidine derivatives incorporating a benzothiazole moiety. |
| AID642912 | Antifungal activity against Candida albicans ATCC 32354 | 2011 | ACS medicinal chemistry letters, May-12, Volume: 2, Issue:5 | Natural Product Based 6-Hydroxy-2,3,4,6-tetrahydropyrrolo[1,2-a]pyrimidinium Scaffold as A New Antifungal Template. |
| AID1472855 | Inhibition of 14alpha-demethylase in Candida albicans ATCC 10231 assessed as 14alpha-methyl ergosta-8,24(28)-dien-3beta,6alpha-diol levels at 1.95 ug/mL by GC-MS analysis | 2018 | Journal of medicinal chemistry, 01-11, Volume: 61, Issue:1 | Alkylated Piperazines and Piperazine-Azole Hybrids as Antifungal Agents. |
| AID518689 | Antimicrobial activity against Cryptococcus gattii serotype B isolate NIH409 assessed as heteroresistant isolates at 16 ug/ml | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Heteroresistance of Cryptococcus gattii to fluconazole. |
| AID1246584 | Antifungal activity against Cryptococcus gattii L24/01 after 48 to 72 hrs by broth microdilution method | 2015 | European journal of medicinal chemistry, Sep-18, Volume: 102 | Thiazole compounds with activity against Cryptococcus gattii and Cryptococcus neoformans in vitro. |
| AID750760 | Antifungal activity against Trichoderma viride MTCC 1107 assessed as zone of inhibition at 80 uM after 48 hrs by disc diffusion method | 2013 | European journal of medicinal chemistry, Jun, Volume: 64 | Biological activity, design, synthesis and structure activity relationship of some novel derivatives of curcumin containing sulfonamides. |
| AID294567 | Antimicrobial activity against Candida tropicalis IP 2031 at 20 ug by disk diffusion method | 2007 | European journal of medicinal chemistry, Jun, Volume: 42, Issue:6 | Rapid synthesis of sulfone derivatives as potential anti-infectious agents. |
| AID1872520 | Antifungal activity against Cryptococcus neoformans TIMM 1855 by 96-well microplate method | 2022 | European journal of medicinal chemistry, Mar-05, Volume: 231 | Synthetic approaches and structural diversity of triazolylbutanols derived from voriconazole in the antifungal drug development. |
| AID495360 | Antimicrobial activity against Candida albicans isolate SC5314 expressing UPC2/UPC2 A643T mutant allele by microdilution method relative wild type | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | An A643T mutation in the transcription factor Upc2p causes constitutive ERG11 upregulation and increased fluconazole resistance in Candida albicans. |
| AID424658 | Antimicrobial activity against azole-resistant Candida albicans isolate CA10 assessed as growth at 64 ug/ml cotreated with 0.063 ug/ml calcineurin signaling inhibitor Tacrolimus after 48 hrs by microdilution checkboard technique relative to control | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | In vitro interactions between tacrolimus and azoles against Candida albicans determined by different methods. |
| AID1818290 | Inhibition of SE/CYP51 in Candida albicans ATCC SC5314 assessed as eburicol level incubated for 48 hrs by LC/MS analysis (Rvb = 2.8 %) | |||
| AID1369533 | Antifungal activity against Candida albicans 58288 after 48 hrs by broth microdilution method | 2018 | Journal of medicinal chemistry, 05-10, Volume: 61, Issue:9 | Combating Drug-Resistant Fungi with Novel Imperfectly Amphipathic Palindromic Peptides. |
| AID521506 | Antifungal activity against Saccharomyces cerevisiae ATCC 24657 after 48 hrs by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | In vitro and in vivo antifungal activities of T-2307, a novel arylamidine. |
| AID584408 | Antifungal activity against 10 days cultured Candida glabrata isolated from neutropenic subject with AML or MDS stool receiving antifungal therapy for 37 days after 9 days of prophylaxis by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Impact of antifungal prophylaxis on colonization and azole susceptibility of Candida species. |
| AID774837 | Antifungal activity against Aspergillus flavus at 0.5 to 1 mg/ml at 25 degC after 3 days by well plate method | 2013 | European journal of medicinal chemistry, Oct, Volume: 68 | Synthesis, characterization and molecular docking studies of some new 1,3,4-oxadiazolines bearing 6-methylpyridine moiety for antimicrobial property. |
| AID356442 | Antifungal activity against Candida albicans ATCC 90028 after 24 to 48 hrs by NCCLS method | 2003 | Journal of natural products, Aug, Volume: 66, Issue:8 | Acetylenic acids inhibiting azole-resistant Candida albicans from Pentagonia gigantifolia. |
| AID625292 | Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) combined score | 2011 | PLoS computational biology, Dec, Volume: 7, Issue:12 | Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). |
| AID1348085 | Antimicrobial activity against Klebsiella oxytoca ATCC 8724 assessed as zone of inhibition at 50 ug per disc after 24 hrs by disc diffusion assay | 2018 | European journal of medicinal chemistry, Jan-01, Volume: 143 | Synthesis of new 1-benzyl tetrahydropyridinylidene ammonium salts and their antimicrobial and anticellular activities. |
| AID563609 | Effect on sterol composition in Candida albicans isolate 108 harboring erg11 and erg5 double mutant assessed as 14alpha-Methylfecosterol level after 2 hrs by gas chromatography | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | A clinical isolate of Candida albicans with mutations in ERG11 (encoding sterol 14alpha-demethylase) and ERG5 (encoding C22 desaturase) is cross resistant to azoles and amphotericin B. |
| AID1196801 | Cytotoxicity against rat L6 cells assessed as growth inhibition after 72 hrs by Alamar Blue assay | 2015 | Journal of medicinal chemistry, Feb-12, Volume: 58, Issue:3 | Novel 3-nitrotriazole-based amides and carbinols as bifunctional antichagasic agents. |
| AID582999 | Antimicrobial activity against Saccharomyces cerevisiae YUG37 transformed with plasmid carrying cyp51B gene with doxycycline-regulatable promoter by broth dilution method in presence of doxycycline | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | Complementation of a Saccharomyces cerevisiae ERG11/CYP51 (sterol 14α-demethylase) doxycycline-regulated mutant and screening of the azole sensitivity of Aspergillus fumigatus isoenzymes CYP51A and CYP51B. |
| AID766648 | Antifungal activity against Candida albicans MTCC 3017 after 24 hrs by well diffusion method | 2013 | European journal of medicinal chemistry, Sep, Volume: 67 | Total synthesis and biological evaluation of clavaminol-G and its analogs. |
| AID1369477 | Antifungal activity against Candida albicans cgmcc 2.2086 in presence of NaCl by broth dilution method | 2018 | Journal of medicinal chemistry, 05-10, Volume: 61, Issue:9 | Combating Drug-Resistant Fungi with Novel Imperfectly Amphipathic Palindromic Peptides. |
| AID1877290 | Antifungal activity against FLC-resistant Candida albicans 632 assessed as fungal growth inhibition by NCCLS protocol based method | 2022 | European journal of medicinal chemistry, Jan-05, Volume: 227 | Broadening antifungal spectrum and improving metabolic stablity based on a scaffold strategy: Design, synthesis, and evaluation of novel 4-phenyl-4,5-dihydrooxazole derivatives as potent fungistatic and fungicidal reagents. |
| AID279116 | Antimicrobial activity against Candida parapsilosis at 48 hrs | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Association of fluconazole area under the concentration-time curve/MIC and dose/MIC ratios with mortality in nonneutropenic patients with candidemia. |
| AID565403 | Antifungal activity against Rhizopus microsporus IHEM 4770 by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Correlation of in vitro activity, serum levels, and in vivo efficacy of posaconazole against Rhizopus microsporus in a murine disseminated infection. |
| AID1898168 | Antifungal activity against Candida parapsilosis 700 | |||
| AID416944 | Antifungal activity against Fusarium oxysporum by broth microdilution test | 2009 | Bioorganic & medicinal chemistry, Mar-15, Volume: 17, Issue:6 | Exploration of click reaction for the synthesis of modified nucleosides as chitin synthase inhibitors. |
| AID1154814 | Antifungal activity against fluconazole-sensitive Candida albicans SC5314 after 24 hrs by serial dilution method | 2014 | ACS medicinal chemistry letters, May-08, Volume: 5, Issue:5 | Novel carboline derivatives as potent antifungal lead compounds: design, synthesis, and biological evaluation. |
| AID405276 | Antifungal activity against Sporothrix schenckii P3287 isolate from cutaneous-lymphatic sporotrichosis patient after 72 hrs by ATB Fungus 2 method | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | In vitro susceptibility of Sporothrix schenckii to six antifungal agents determined using three different methods. |
| AID1328362 | Selectivity index, ratio of IC50 for pig LLC-PK1 cells to MIC for Cryptococcus neoformans ATCC 90113 | 2016 | Journal of natural products, 09-23, Volume: 79, Issue:9 | Synthesis of Natural Acylphloroglucinol-Based Antifungal Compounds against Cryptococcus Species. |
| AID625772 | Antifungal activity against Candida krusei ATCC 6258 after 24 hrs by serial dilution method | 2011 | European journal of medicinal chemistry, Nov, Volume: 46, Issue:11 | Design and synthesis of novel triazole antifungal derivatives by structure-based bioisosterism. |
| AID1822494 | Antifungal activity against Candida albicans SN152 assessed as reduction in drug tolerance by measuring zone of inhibition at 25 ug incubated for 24 to 48 hrs by disk diffusion assay | 2022 | Journal of medicinal chemistry, 02-10, Volume: 65, Issue:3 | Fluconazole-COX Inhibitor Hybrids: A Dual-Acting Class of Antifungal Azoles. |
| AID613713 | Antifungal activity against Candida albicans ATCC 24433 by broth dilution method | 2011 | Bioorganic & medicinal chemistry letters, Aug-15, Volume: 21, Issue:16 | Novel hybrids of fluconazole and furanones: design, synthesis and antifungal activity. |
| AID1157297 | Antifungal activity against Microsporum gypseum Cmccfmza assessed as growth inhibition by automatic microplate reader analysis | 2014 | Journal of natural products, May-23, Volume: 77, Issue:5 | Polyhydroxy cyclohexanols from a Dendrodochium sp. fungus associated with the sea cucumber Holothuria nobilis Selenka. |
| AID410997 | Antifungal activity against Candida glabrata DSM6425 after 24 hrs by broth macrodilution method | 2009 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 19, Issue:1 | One-pot synthesis of 5-phenylimino, 5-thieno or 5-oxo-1,2,3-dithiazoles and evaluation of their antimicrobial and antitumor activity. |
| AID582221 | Antifungal activity against Candida krusei isolated from HSCT recipients with acute or chronic GVHD receiving posaconazole by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Impact of antifungal prophylaxis on colonization and azole susceptibility of Candida species. |
| AID375815 | Antifungal activity against Aspergillus flavus NCIM 539 by agar plate assay | 2009 | Bioorganic & medicinal chemistry letters, Jul-01, Volume: 19, Issue:13 | Synthesis of novel 3-(1-(1-substituted piperidin-4-yl)-1H-1,2,3-triazol-4-yl)-1,2,4-oxadiazol-5(4H)-one as antifungal agents. |
| AID436791 | Antifungal activity against Aspergillus fumigatus after 48 hrs by twofold tube dilution method | 2009 | European journal of medicinal chemistry, Oct, Volume: 44, Issue:10 | Synthesis and evaluation of in vitro anti-microbial and anti-tubercular activity of 2-styryl benzimidazoles. |
| AID1357635 | Antifungal activity against Cryptococcus gattii ATCC 32608 after 72 hrs by microbroth dilution assay | 2018 | European journal of medicinal chemistry, May-10, Volume: 151 | Synthesis, molecular modeling studies and evaluation of antifungal activity of a novel series of thiazole derivatives. |
| AID1728468 | Antifungal activity against Candida albicans ATCC SC5314 assessed as reduction in cell division at 10 nM/mL by polarizing microscopy | 2021 | European journal of medicinal chemistry, Jan-15, Volume: 210 | Novel naphthylamide derivatives as dual-target antifungal inhibitors: Design, synthesis and biological evaluation. |
| AID1054672 | Antimicrobial activity against Aspergillus fumigatus ATCC 204305 by Alamar blue method | 2013 | European journal of medicinal chemistry, , Volume: 70 | Structure-activity relationship (SAR) and preliminary mode of action studies of 3-substituted benzylthioquinolinium iodide as anti-opportunistic infection agents. |
| AID1254320 | Antifungal activity against Candida glabrata 20/I after 24 hrs by microdilution broth method | 2015 | Bioorganic & medicinal chemistry, Nov-15, Volume: 23, Issue:22 | Novel derivatives of nitro-substituted salicylic acids: Synthesis, antimicrobial activity and cytotoxicity. |
| AID638567 | Antifungal activity against Aspergillus flavus KCCM 11899 after 2 days by two fold broth dilution method | 2012 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 22, Issue:1 | Synthesis and antifungal evaluation of pyrido[1,2-a]indole-1,4-diones and benzo[f]pyrido[1,2-a]indole-6,11-diones. |
| AID1859325 | Antimicrobial activity against Candida albicans 901 | 2022 | Journal of medicinal chemistry, 02-24, Volume: 65, Issue:4 | Application of the All-Hydrocarbon Stapling Technique in the Design of Membrane-Active Peptides. |
| AID1268013 | Antifungal activity against Aspergillus niger assessed as growth inhibition incubated for 72 hrs at 37 degC by broth dilution method | 2016 | Bioorganic & medicinal chemistry letters, Jan-15, Volume: 26, Issue:2 | Synthesis of novel coumarin appended bis(formylpyrazole) derivatives: Studies on their antimicrobial and antioxidant activities. |
| AID1201587 | Antifungal activity against Candida albicans at 0.5 mg/ml incubated for 3 days | 2015 | European journal of medicinal chemistry, May-05, Volume: 95 | Synthesis and biological evaluation of new imidazo[2,1-b][1,3,4]thiadiazole-benzimidazole derivatives. |
| AID208064 | In vitro antifungal activity against Trichophyton rubrum CM1447 | 2002 | Journal of medicinal chemistry, Oct-24, Volume: 45, Issue:22 | Synthesis, antifungal activity, and molecular modeling studies of new inverted oxime ethers of oxiconazole. |
| AID510620 | Antifungal activity against Aspergillus fumigatus by serial dilution method | 2010 | European journal of medicinal chemistry, Sep, Volume: 45, Issue:9 | Design, synthesis and antifungal activity of isosteric analogues of benzoheterocyclic N-myristoyltransferase inhibitors. |
| AID1507060 | Antifungal activity against Candida albicans ATCC 76615 after 24 hrs by NCCLS two fold broth microdilution method | 2017 | European journal of medicinal chemistry, Aug-18, Volume: 136 | Design, synthesis and antimicrobial evaluation of novel benzimidazole-incorporated sulfonamide analogues. |
| AID1602400 | Antifungal activity against Cryptococcus neoformans H99 assessed as up-regulation of cyclin B1 expression at 2 to 4 ug/ml after 24 hrs by Western blot analysis | 2019 | Journal of medicinal chemistry, 03-14, Volume: 62, Issue:5 | Discovery of Carboline Derivatives as Potent Antifungal Agents for the Treatment of Cryptococcal Meningitis. |
| AID424899 | Antimicrobial activity against azole-resistant Candida albicans isolate CA10 assessed as growth at 0.125 ug/ml cotreated with 0.008 ug/ml calcineurin signaling inhibitor tacrolimus after 48 hrs by microdilution checkerboard technique relative to control | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | In vitro interactions between tacrolimus and azoles against Candida albicans determined by different methods. |
| AID1719768 | Antifungal activity against Candida albicans ATCC 90028 assessed as growth inhibition incubated for 36 hrs | |||
| AID424914 | Antimicrobial activity against azole-resistant Candida albicans isolate CA10 assessed as growth at 2 ug/ml cotreated with 0.004 ug/ml calcineurin signaling inhibitor tacrolimus after 48 hrs by microdilution checkerboard technique relative to control | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | In vitro interactions between tacrolimus and azoles against Candida albicans determined by different methods. |
| AID279115 | Antimicrobial activity against Candida glabrata at 48 hrs | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Association of fluconazole area under the concentration-time curve/MIC and dose/MIC ratios with mortality in nonneutropenic patients with candidemia. |
| AID1465977 | Antifungal activity against Candida krusei ATCC 34135 after 44 hrs by broth dilution assay | 2017 | Bioorganic & medicinal chemistry, 06-01, Volume: 25, Issue:11 | Investigation of aryl isonitrile compounds with potent, broad-spectrum antifungal activity. |
| AID1904405 | Disruption of membrane integrity in Candida albicans ATCC SC5314 assessed as cell wall damage at 16 ug/ml incubated for 48 hrs by transmission electron microscopy | 2022 | European journal of medicinal chemistry, Apr-05, Volume: 233 | Design, synthesis, and evaluation of novel 3-thiophene derivatives as potent fungistatic and fungicidal reagents based on a conformational restriction strategy. |
| AID48051 | Minimum inhibitory concentration of compound for antifungal activity against Candida parapsilosis | 2000 | Bioorganic & medicinal chemistry letters, Oct-02, Volume: 10, Issue:19 | Novel antifungals based on 4-substituted imidazole: a combinatorial chemistry approach to lead discovery and optimization. |
| AID407013 | Antimicrobial activity against Cdr1, Cdr2 and Mdr1 deficient Candida albicans DSY1050 at planktonic cell density of 10'3 cells/ml after 48 hrs by XTT assay | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | Role for cell density in antifungal drug resistance in Candida albicans biofilms. |
| AID432799 | Antifungal activity against Sporothrix brasiliensis after 72 hrs by microdilution method | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | In vitro antifungal susceptibilities of five species of sporothrix. |
| AID521974 | Antibacterial activity against azole-susceptible Candida albicans DSY294 containing CIp10 to restore URA3 function infected in BALB/c mouse administered intraperitoneally 1 hr post bacterial challenge measured 3 days post infection | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Genetic dissection of azole resistance mechanisms in Candida albicans and their validation in a mouse model of disseminated infection. |
| AID609892 | Antifungal activity against Candida parapsilosis by micro-broth dilution method | 2011 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 21, Issue:15 | Synthesis, in vitro evaluation and molecular docking studies of new triazole derivatives as antifungal agents. |
| AID1205749 | Antifungal activity against Cryptococcus gattii 1913ER after 72 hrs by microdilution method | 2015 | ACS medicinal chemistry letters, Mar-12, Volume: 6, Issue:3 | Synthesis of a New Peptide-Coumarin Conjugate: A Potential Agent against Cryptococcosis. |
| AID1157296 | Antifungal activity against Trichophyton rubrum Cmccftla assessed as growth inhibition by automatic microplate reader analysis | 2014 | Journal of natural products, May-23, Volume: 77, Issue:5 | Polyhydroxy cyclohexanols from a Dendrodochium sp. fungus associated with the sea cucumber Holothuria nobilis Selenka. |
| AID283230 | Prolongation of survival in po dosed CD1 mouse infected with Coccidioides immitis Silveira administered after 3 days of infection after 12 days relative to control | 2007 | Antimicrobial agents and chemotherapy, Mar, Volume: 51, Issue:3 | Comparison of itraconazole and fluconazole treatments in a murine model of coccidioidal meningitis. |
| AID561420 | Antifungal activity against REPF URA3 fcy1-deficient Candida lusitaniae by microdilution method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Nonsense and missense mutations in FCY2 and FCY1 genes are responsible for flucytosine resistance and flucytosine-fluconazole cross-resistance in clinical isolates of Candida lusitaniae. |
| AID490490 | Antifungal activity against Aspergillus niger MTCC 282 at 30 ug/ml after 48 hrs by cup-plate method | 2010 | European journal of medicinal chemistry, Jul, Volume: 45, Issue:7 | Synthesis and evaluation of some new benzothiazole derivatives as potential antimicrobial agents. |
| AID405212 | Antimicrobial activity against Blastoschizomyces capitatus IHEM 5666 isolate infected OF1 mouse blastoschizomycosis model assessed as liver microbial count per gram of tissue at 80 mg/kg/day, po for 6 days administered 1 hr before microbial challenge | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | Combined therapies in a murine model of blastoschizomycosis. |
| AID425147 | Antimicrobial activity against azole-resistant Candida albicans isolate CA10 assessed as growth at 128 ug/ml after 48 hrs by microdilution checkerboard technique relative to control | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | In vitro interactions between tacrolimus and azoles against Candida albicans determined by different methods. |
| AID1905338 | Induction of morphological changes in Candida albicans 904 assessed as hyphal formation by measuring CPH1 level incubated for 4 hrs | 2022 | Journal of medicinal chemistry, 04-14, Volume: 65, Issue:7 | Species-Selective Targeting of Fungal Hsp90: Design, Synthesis, and Evaluation of Novel 4,5-Diarylisoxazole Derivatives for the Combination Treatment of Azole-Resistant Candidiasis. |
| AID515330 | Antifungal activity against Candida mycoderma by twofold serial dilution technique | 2010 | European journal of medicinal chemistry, Oct, Volume: 45, Issue:10 | Synthesis of novel sulfanilamide-derived 1,2,3-triazoles and their evaluation for antibacterial and antifungal activities. |
| AID1192375 | Antimicrobial activity against Escherichia coli MTCC 1089 after 18 hrs by broth micro dilution method | 2015 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 25, Issue:7 | Synthesis and antimicrobial activity of novel benzoxazine sulfonamide derivatives. |
| AID493518 | Antifungal activity against Candida glabrata 20/I after 48 hrs by broth microdilution assay | 2010 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 20, Issue:15 | N-Benzylsalicylthioamides as novel compounds with promising antimycotic activity. |
| AID515010 | Antifungal activity against Cryptococcus neoformans after 72 hrs by micro-broth dilution method | 2010 | European journal of medicinal chemistry, Oct, Volume: 45, Issue:10 | Synthesis and antifungal evaluation of novel triazole derivatives as inhibitors of cytochrome P450 14alpha-demethylase. |
| AID581893 | Antifungal activity against Candida albicans isolated from HSCT recipient 042 with acute or chronic GVHD mouth receiving antifungal drug after 112 days prophylaxis by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Impact of antifungal prophylaxis on colonization and azole susceptibility of Candida species. |
| AID745262 | Antifungal activity against Candida albicans clinical isolate after 18 to 24 hrs by micro-dilution method | 2013 | European journal of medicinal chemistry, May, Volume: 63 | Design, synthesis and antimicrobial activity of novel benzothiazole analogs. |
| AID1391315 | Antifungal activity against Candida albicans 7535 after 24 hrs by two-fold serial dilution method | 2018 | Bioorganic & medicinal chemistry letters, 05-15, Volume: 28, Issue:9 | Synthesis and evaluation of the antibacterial activities of aryl substituted dihydrotriazine derivatives. |
| AID1674367 | Clearance in human | 2020 | Journal of medicinal chemistry, 11-12, Volume: 63, Issue:21 | Integrating the Impact of Lipophilicity on Potency and Pharmacokinetic Parameters Enables the Use of Diverse Chemical Space during Small Molecule Drug Optimization. |
| AID568476 | Antifungal activity against Candida albicans KCCM 50235 after 1 day by twofold broth dilution method | 2011 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 21, Issue:3 | Synthesis and antifungal activity of furo[2,3-f]quinolin-5-ols. |
| AID1271243 | Antifungal activity against Aspergillus niger ATCC 10578 after 48 hrs by broth microdilution method | 2015 | ACS medicinal chemistry letters, Nov-12, Volume: 6, Issue:11 | Silicon Incorporated Morpholine Antifungals: Design, Synthesis, and Biological Evaluation. |
| AID1374423 | Antifungal activity against Candida tropicalis ATCC 750 after 48 hrs by microdilution broth method | 2018 | Bioorganic & medicinal chemistry letters, 03-01, Volume: 28, Issue:5 | Synthesis, antimicrobial activity and acid dissociation constants of methyl 5,5-diphenyl-1-(thiazol-2-yl)pyrrolidine-2-carboxylate derivatives. |
| AID598297 | Antimicrobial activity against Candida parapsilosis isolate 39 after 48 hrs by microdilution broth method | 2011 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 21, Issue:11 | Synthesis and in vitro antimicrobial activities of new (cyano-NNO-azoxy)pyrazole derivatives. |
| AID1054674 | Antimicrobial activity against Candida albicans ATCC 90028 by Alamar blue method | 2013 | European journal of medicinal chemistry, , Volume: 70 | Structure-activity relationship (SAR) and preliminary mode of action studies of 3-substituted benzylthioquinolinium iodide as anti-opportunistic infection agents. |
| AID490936 | Antifungal activity against Aspergillus niger NCIM 545 after 72 hrs by disc diffusion method | 2010 | European journal of medicinal chemistry, Jul, Volume: 45, Issue:7 | Synthesis and biological evaluation of a novel series of 2,2-bisaminomethylated aurone analogues as anti-inflammatory and antimicrobial agents. |
| AID609891 | Antifungal activity against Candida tropicalis by micro-broth dilution method | 2011 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 21, Issue:15 | Synthesis, in vitro evaluation and molecular docking studies of new triazole derivatives as antifungal agents. |
| AID1401697 | Antifungal against Aspergillus flavus after 24 hrs by two fold serial dilution method | 2018 | European journal of medicinal chemistry, Jan-01, Volume: 143 | Novel aminopyrimidinyl benzimidazoles as potentially antimicrobial agents: Design, synthesis and biological evaluation. |
| AID332286 | Antimicrobial activity against Candida krusei after 16 to 18 hrs by microbroth dilution assay | 2002 | Journal of natural products, Mar, Volume: 65, Issue:3 | (+)-7S-Hydroxyxestospongin A from the marine sponge Xestospongia sp. and absolute configuration of (+)-xestospongin D. |
| AID1205747 | Antifungal activity against Cryptococcus gattii ATCC 32608 after 72 hrs by microdilution method | 2015 | ACS medicinal chemistry letters, Mar-12, Volume: 6, Issue:3 | Synthesis of a New Peptide-Coumarin Conjugate: A Potential Agent against Cryptococcosis. |
| AID1444336 | Antifungal activity against Candida albicans ATCC 44859 after 24 hrs by broth microdilution method | 2017 | European journal of medicinal chemistry, Apr-21, Volume: 130 | Structure-activity relationship studies on 3,5-dinitrophenyl tetrazoles as antitubercular agents. |
| AID776456 | Antimicrobial activity against Saccharomyces cerevisiae RSKK 251 at 5 ug | 2013 | European journal of medicinal chemistry, Nov, Volume: 69 | Design, synthesis and biological activities of some 7-aminocephalosporanic acid derivatives. |
| AID518456 | Antimicrobial activity against Cryptococcus gattii serotype C isolate H0058-1-78 assessed as heteroresistant isolates at 4 ug/ml | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Heteroresistance of Cryptococcus gattii to fluconazole. |
| AID55029 | Evaluation of In vitro antifungal activity against Cryptococcus neoformans 74 by broth macro dilution method | 1995 | Journal of medicinal chemistry, Sep-29, Volume: 38, Issue:20 | Synthesis and antifungal activity of new azole derivatives containing an N-acylmorpholine ring. |
| AID1330191 | Antibacterial activity against Salmonella typhimurium 1926 measured after 24 hrs by two-fold serial dilution method | 2016 | Bioorganic & medicinal chemistry letters, 12-15, Volume: 26, Issue:24 | Synthesis and biological evaluation of chalcone derivatives containing aminoguanidine or acylhydrazone moieties. |
| AID519283 | Antifungal activity against Candida krusei ATCC 6258 by WIDERYST method | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | Reliability of the WIDERYST susceptibility testing system for detection of in vitro antifungal resistance in yeasts. |
| AID1783064 | Antifungal activity against Cryptococcus neoformans H99 assessed as inhibition of fungal growth incubated for 72 hrs by two-fold serial microdilution method | 2021 | European journal of medicinal chemistry, Oct-05, Volume: 221 | Lanosterol 14α-demethylase (CYP51)/histone deacetylase (HDAC) dual inhibitors for treatment of Candida tropicalis and Cryptococcus neoformans infections. |
| AID619183 | Antifungal activity against Candida albicans AN 562 by broth dilution method | 2011 | Journal of medicinal chemistry, Oct-13, Volume: 54, Issue:19 | High-throughput-screening-based identification and structure-activity relationship characterization defined (S)-2-(1-aminoisobutyl)-1-(3-chlorobenzyl)benzimidazole as a highly antimycotic agent nontoxic to cell lines. |
| AID1369482 | Antifungal activity against Candida albicans cgmcc 2.2086 in presence of ZnCl2 by broth dilution method | 2018 | Journal of medicinal chemistry, 05-10, Volume: 61, Issue:9 | Combating Drug-Resistant Fungi with Novel Imperfectly Amphipathic Palindromic Peptides. |
| AID1193499 | Thermodynamic equilibrium solubility, log S of the compound simulated intestinal fluid at pH 6.8 at RT after 24 hrs by shake-flask method | 2015 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 25, Issue:7 | Thermodynamic equilibrium solubility measurements in simulated fluids by 96-well plate method in early drug discovery. |
| AID1254071 | Antibacterial activity against Escherichia coli KCTC 1924 after 24 hrs by two-fold serial dilution method | 2015 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 25, Issue:22 | Synthesis and biological evaluation of 1,3-diaryl pyrazole derivatives as potential antibacterial and anti-inflammatory agents. |
| AID289500 | Antifungal activity against Trichophyton mentagrophytes 445(TM) by broth microdilution test | 2007 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 17, Issue:1 | Microwave prompted multigram synthesis, structural determination, and photo-antiproliferative activity of fluorinated 4-hydroxyquinolinones. |
| AID486965 | Antifungal activity against Sporothrix schenckii after 72 hrs by micro broth dilution method | 2010 | European journal of medicinal chemistry, Jun, Volume: 45, Issue:6 | 'On water' assisted synthesis and biological evaluation of nitrogen and sulfur containing hetero-1,4-naphthoquinones as potent antifungal and antibacterial agents. |
| AID453443 | Antifungal activity against Aspergillus niger ATCC 16404 after 48 hrs by broth microdilution method | 2010 | Bioorganic & medicinal chemistry letters, Jan-15, Volume: 20, Issue:2 | Fluconazole analogues containing 2H-1,4-benzothiazin-3(4H)-one or 2H-1,4-benzoxazin-3(4H)-one moieties, a novel class of anti-Candida agents. |
| AID771484 | Antimicrobial activity against Candida albicans MTCC 183 at 100 ug/mL after 12 hrs by well diffusion method | 2013 | European journal of medicinal chemistry, Oct, Volume: 68 | Design and regioselective synthesis of trifluoromethylquinolone derivatives as potent antimicrobial agents. |
| AID39390 | In vitro evaluation of minimum inhibitory concentration against Aspergillus flavus 19 | 1995 | Journal of medicinal chemistry, Sep-29, Volume: 38, Issue:20 | Synthesis and antifungal activity of new azole derivatives containing an N-acylmorpholine ring. |
| AID405094 | Antimicrobial activity against Rhizopus microsporus var. rhizopodiformis after 24 hrs | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | In vitro susceptibilities of 217 clinical isolates of zygomycetes to conventional and new antifungal agents. |
| AID1491270 | Inhibition of CYP51 in Candida albicans ATCC SC5314 assessed as 4,4-dimethyl zymosterol content at 2 ug/ml by GS-MS analysis relative to total sterols | 2017 | European journal of medicinal chemistry, Sep-08, Volume: 137 | Design, synthesis and evaluation of aromatic heterocyclic derivatives as potent antifungal agents. |
| AID1565877 | Antifungal activity against Candida albicans ATCC 90023 assessed as growth inhibition measured after 24 hrs by two-fold broth dilution method | 2019 | European journal of medicinal chemistry, Nov-15, Volume: 182 | Design, synthesis and biological evaluation of novel diazaspiro[4.5]decan-1-one derivatives as potential chitin synthase inhibitors and antifungal agents. |
| AID1754370 | Antifungal activity against Trichophyton interdigitale ATCC 9533 assessed as reduction in fungal growth incubated for 72 hrs by broth microdilution method based spectrophotometric analysis | 2021 | Bioorganic & medicinal chemistry, 07-01, Volume: 41 | Iodinated 1,2-diacylhydrazines, benzohydrazide-hydrazones and their analogues as dual antimicrobial and cytotoxic agents. |
| AID1054666 | Antimicrobial activity against Candida krusei ATCC 6258 by Alamar blue method | 2013 | European journal of medicinal chemistry, , Volume: 70 | Structure-activity relationship (SAR) and preliminary mode of action studies of 3-substituted benzylthioquinolinium iodide as anti-opportunistic infection agents. |
| AID1551293 | Antibacterial activity against Streptococcus mutans KCTC3289 assessed as reduction in bacterial cell growth incubated for 24 hrs by ELISA | 2019 | European journal of medicinal chemistry, Jun-15, Volume: 172 | Synthesis and biological evaluation of tryptophan-derived rhodanine derivatives as PTP1B inhibitors and anti-bacterial agents. |
| AID1465976 | Antifungal activity against Candida krusei ATCC 14243 after 44 hrs by broth dilution assay | 2017 | Bioorganic & medicinal chemistry, 06-01, Volume: 25, Issue:11 | Investigation of aryl isonitrile compounds with potent, broad-spectrum antifungal activity. |
| AID1609932 | Antifungal activity against fluconazole-resistant Candida albicans 901 assessed as reduction in fungal growth incubated for 24 hrs by serial dilution method | |||
| AID249258 | Antifungal activity to cause 99% reduction of surviving cells in 90% isolates | 2004 | Journal of medicinal chemistry, Jul-29, Volume: 47, Issue:16 | Imidazole analogues of fluoxetine, a novel class of anti-Candida agents. |
| AID466908 | Antimicrobial activity against Candida albicans after 16 to 18 hrs by serial dilution method | 2010 | European journal of medicinal chemistry, Mar, Volume: 45, Issue:3 | Synthesis, characterization and biological activity of some new 1,3,4-oxadiazole bearing 2-flouro-4-methoxy phenyl moiety. |
| AID644831 | Antifungal activity against Candida albicans ATCC 10231 after 48 hrs by M27-A3 CLSI method | 2012 | European journal of medicinal chemistry, Mar, Volume: 49 | Synthesis and antifungal activity of a new series of 2-(1H-imidazol-1-yl)-1-phenylethanol derivatives. |
| AID1193495 | Thermodynamic equilibrium solubility, log S of the compound in simulated intestinal fluid at pH 6.8 at RT after 4 hrs by 96 well plate method | 2015 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 25, Issue:7 | Thermodynamic equilibrium solubility measurements in simulated fluids by 96-well plate method in early drug discovery. |
| AID1783079 | Downregulation of CAP10 gene expression in Cryptococcus neoformans H99 at 2 ug/ml measured after 24 hrs by qRT-PCR analysis | 2021 | European journal of medicinal chemistry, Oct-05, Volume: 221 | Lanosterol 14α-demethylase (CYP51)/histone deacetylase (HDAC) dual inhibitors for treatment of Candida tropicalis and Cryptococcus neoformans infections. |
| AID562997 | Antifungal activity against Candida albicans isolate 03-2718 infected BALB/c mouse vaginitis model assessed as reduction in fungal load in vagina at 20 mg/kg, administered through oral gavage once daily for 5 days measured on day 1 post inoculation | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | Efficacy of albaconazole against Candida albicans in a vaginitis model. |
| AID625774 | Antifungal activity against Aspergillus fumigatus 7544 after 7 days by serial dilution method | 2011 | European journal of medicinal chemistry, Nov, Volume: 46, Issue:11 | Design and synthesis of novel triazole antifungal derivatives by structure-based bioisosterism. |
| AID392368 | Antifungal activity against Candida albicans ATCC 44859 after 48 hrs by broth microdilution method | 2009 | Bioorganic & medicinal chemistry letters, Jan-15, Volume: 19, Issue:2 | Salicylanilide esters of N-protected amino acids as novel antimicrobial agents. |
| AID1168339 | Binding affinity to human serum albumin by spectroscopy in presence of Ni2+ | 2014 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 24, Issue:21 | Study the interactions between human serum albumin and two antifungal drugs: fluconazole and its analogue DTP. |
| AID1890280 | Antifungal activity against Trichophyton rubrum clinical isolate 1 assessed as reduction in fungal growth by broth dilution method | 2022 | Bioorganic & medicinal chemistry letters, 05-01, Volume: 63 | Novel 2-aryl-4-aryloxyquinoline-based fungistatics for Mucor circinelloides. Biological evaluation of activity, QSAR and docking study. |
| AID518178 | Antimicrobial activity against Cryptococcus gattii serotype B isolate NIH444 assessed as heteroresistant isolates at 2 ug/ml | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Heteroresistance of Cryptococcus gattii to fluconazole. |
| AID738391 | Antibacterial activity against Staphylococcus aureus ATCC 6538 after 24 hrs by NCCLS method | 2013 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 23, Issue:7 | Efficient synthesis and antimicrobial activity of some novel S-β-d-glucosides of 5-aryl-1,2,4-triazole-3-thiones derivatives. |
| AID319754 | Antimicrobial activity against Aspergillus fumigatus isolates | 2008 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 18, Issue:11 | Synthesis and SAR studies of biaryloxy-substituted triazoles as antifungal agents. |
| AID719033 | Antifungal activity against Candida albicans ATCC 44859 assessed as growth inhibition after 24 hrs by CLSI M27-A2 broth microdilution method | 2012 | Bioorganic & medicinal chemistry, Dec-15, Volume: 20, Issue:24 | Anti-infective and herbicidal activity of N-substituted 2-aminobenzothiazoles. |
| AID625281 | Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for cholelithiasis | 2011 | PLoS computational biology, Dec, Volume: 7, Issue:12 | Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). |
| AID699541 | Inhibition of human liver OATP2B1 expressed in HEK293 Flp-In cells assessed as reduction in [3H]E3S uptake at 20 uM incubated for 5 mins by scintillation counting | 2012 | Journal of medicinal chemistry, May-24, Volume: 55, Issue:10 | Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions. |
| AID1494175 | Antifungal activity against fluconazole/ITC-susceptible Candida albicans ATCC MYA-2876 measured after 48 hrs by CLSI M27-A3 protocol based method | 2018 | Bioorganic & medicinal chemistry, 02-01, Volume: 26, Issue:3 | Novel fluconazole derivatives with promising antifungal activity. |
| AID1246666 | Antifungal activity against Cryptococcus gattii ICB181 assessed as reduction in cell viability at 26 uM after 6 to 72 hrs by MTT assay | 2015 | European journal of medicinal chemistry, Sep-18, Volume: 102 | Thiazole compounds with activity against Cryptococcus gattii and Cryptococcus neoformans in vitro. |
| AID1329221 | Inhibition of CDR1/CDR2 in Candida albicans clinical isolate 24D assessed as potentiation of fluconazole-induced antifungal activity by measuring fluconazole MIC80 up to 8 ug/ml after 24 hrs by XTT based broth microdilution assay (Rvb = >128 ug/ml) | 2016 | Journal of natural products, 09-23, Volume: 79, Issue:9 | Heptaketides from an Endolichenic Fungus Biatriospora sp. and Their Antifungal Activity. |
| AID285856 | Antimicrobial susceptibility of Pichia anomala from nosocomial fungemia patient assessed as percent susceptible isolates at 0.25 ug/ml by CLSI method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Antifungal drug susceptibility profile of Pichia anomala isolates from patients presenting with nosocomial fungemia. |
| AID1367156 | Antifungal activity against Candida glabrata 20/I after 48 hrs by microdilution broth method | 2017 | Bioorganic & medicinal chemistry letters, 12-01, Volume: 27, Issue:23 | Synthesis and biological evolution of hydrazones derived from 4-(trifluoromethyl)benzohydrazide. |
| AID521513 | Antifungal activity against Aspergillus nidulans NBRC 33017 after 48 hrs by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | In vitro and in vivo antifungal activities of T-2307, a novel arylamidine. |
| AID564274 | Antifungal activity against Candida albicans isolate 14 after 48 hrs by broth microdilution method in presence of 10 uM of efflux pump inhibitor FK506 | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | A clinical isolate of Candida albicans with mutations in ERG11 (encoding sterol 14alpha-demethylase) and ERG5 (encoding C22 desaturase) is cross resistant to azoles and amphotericin B. |
| AID1157293 | Antifungal activity against Candida glabrata 537 assessed as growth inhibition by automatic microplate reader analysis | 2014 | Journal of natural products, May-23, Volume: 77, Issue:5 | Polyhydroxy cyclohexanols from a Dendrodochium sp. fungus associated with the sea cucumber Holothuria nobilis Selenka. |
| AID1754367 | Antifungal activity against Candida parapsilosis ATCC 22019 assessed as reduction in fungal growth incubated for 48 hrs by broth microdilution method based spectrophotometric analysis | 2021 | Bioorganic & medicinal chemistry, 07-01, Volume: 41 | Iodinated 1,2-diacylhydrazines, benzohydrazide-hydrazones and their analogues as dual antimicrobial and cytotoxic agents. |
| AID1124799 | Antifungal activity against Sporothrix schenckii clinical isolate after 72 to 96 hrs by standard broth microdilution method | 2014 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 24, Issue:7 | Synthesis and evaluation of new diaryl ether and quinoline hybrids as potential antiplasmodial and antimicrobial agents. |
| AID1609931 | Antifungal activity against fluconazole-resistant Candida albicans 632 assessed as reduction in fungal growth incubated for 24 hrs by serial dilution method | |||
| AID1413926 | Antifungal activity against Aspergillus fumigatus after 24 hrs by microbroth dilution method | 2018 | MedChemComm, Sep-01, Volume: 9, Issue:9 | Novel organophosphorus aminopyrimidines as unique structural DNA-targeting membrane active inhibitors towards drug-resistant methicillin-resistant |
| AID745261 | Antifungal activity against Candida albicans ATCC 90028 after 18 to 24 hrs by micro-dilution metho | 2013 | European journal of medicinal chemistry, May, Volume: 63 | Design, synthesis and antimicrobial activity of novel benzothiazole analogs. |
| AID293592 | Antifungal activity against Candida albicans ATCC 10231 assessed after 48 hrs by serial dilution method | 2007 | Bioorganic & medicinal chemistry, Mar-01, Volume: 15, Issue:5 | Synthesis and biological evaluation of new N-(2-hydroxy-4(or 5)-nitro/aminophenyl)benzamides and phenylacetamides as antimicrobial agents. |
| AID525402 | Antifungal activity against Candida glabrata isolate 4205 after 48 hrs by microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Posaconazole against Candida glabrata isolates with various susceptibilities to fluconazole. |
| AID1918345 | Antifungal activity against Candida albicans assessed as inhibition of fungal cell proliferation by measuring decrease in fungal cell density measured after 24 hrs | 2022 | Journal of medicinal chemistry, 11-10, Volume: 65, Issue:21 | Novel Aryl Alkamidazole Derivatives as Multifunctional Antifungal Inhibitors: Design, Synthesis, and Biological Evaluation. |
| AID269978 | Antifungal activity against Candida albicans 615 | 2006 | Journal of medicinal chemistry, Aug-10, Volume: 49, Issue:16 | Synthesis and antifungal activity of a novel series of alkyldimethylamine cyanoboranes and their derivatives. |
| AID670555 | Antifungal activity against Candida albicans MTCC 3958 after 24 hrs by well diffusion method | 2012 | Bioorganic & medicinal chemistry letters, Jul-15, Volume: 22, Issue:14 | Total synthesis and antifungal activity of (2S,3R)-2-aminododecan-3-ol. |
| AID424657 | Antimicrobial activity against azole-resistant Candida albicans isolate CA10 assessed as growth at 32 ug/ml cotreated with 0.063 ug/ml calcineurin signaling inhibitor Tacrolimus after 48 hrs by microdilution checkboard technique relative to control | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | In vitro interactions between tacrolimus and azoles against Candida albicans determined by different methods. |
| AID1595112 | Antifungal activity against Candida albicans assessed as inhibition zone at 125 ug/ml by disk diffusion method | 2019 | European journal of medicinal chemistry, May-15, Volume: 170 | Tetrazole hybrids and their antifungal activities. |
| AID1584753 | Drug metabolism in human liver microsome S9 fraction assessed as CYP450-mediated metabolism by measuring compound remaining at 5 uM pretreated with NADPH and measured after 60 mins by UPLC-MS/MS analysis | 2018 | Journal of medicinal chemistry, 10-25, Volume: 61, Issue:20 | Discovery of Novel 7-Aryl 7-Deazapurine 3'-Deoxy-ribofuranosyl Nucleosides with Potent Activity against Trypanosoma cruzi. |
| AID494615 | Antifungal activity against Saccharomyces cerevisiae KE744 after 2 days by broth-microdilution method | 2010 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 20, Issue:15 | Synthesis and evaluation of novel antifungal agents-quinoline and pyridine amide derivatives. |
| AID1352424 | Antifungal activity against Aspergillus flavus ATCC 204304 by CLSI two fold serial dilution method | 2018 | European journal of medicinal chemistry, Feb-25, Volume: 146 | Discovery of 2-aminothiazolyl berberine derivatives as effectively antibacterial agents toward clinically drug-resistant Gram-negative Acinetobacter baumanii. |
| AID555583 | Antimicrobial activity against Candida pintolopesii by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Activity profile in vitro of micafungin against Spanish clinical isolates of common and emerging species of yeasts and molds. |
| AID1334853 | Anti-fungal activity against fluconazole-resistant Candida albicans 103 by broth microdilution method | 2017 | Bioorganic & medicinal chemistry, 01-15, Volume: 25, Issue:2 | Discovery of biphenyl imidazole derivatives as potent antifungal agents: Design, synthesis, and structure-activity relationship studies. |
| AID754917 | Antifungal activity against Absidia corymbifera 272 assessed as growth inhibition after 24 to 48 hrs by microbroth dilution method | 2013 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 23, Issue:12 | Synthesis and antimycobacterial evaluation of N-substituted 5-chloropyrazine-2-carboxamides. |
| AID1380515 | Antifungal activity against Candida albicans SC5314 assessed as inhibition of fungal growth incubated for 48 hrs by broth microdilution assay | 2018 | Bioorganic & medicinal chemistry letters, 06-01, Volume: 28, Issue:10 | Biofilm inhibition and anti-Candida activity of a cationic lipo-benzamide molecule with twin-nonyl chain. |
| AID1168350 | Ratio of binding constant for human serum albumin in presence of Fe3+ to binding constant for human serum albumin in absence of metal ions | 2014 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 24, Issue:21 | Study the interactions between human serum albumin and two antifungal drugs: fluconazole and its analogue DTP. |
| AID1549175 | Inhibition of biofilm formation in azole resistant Candida albicans 0304103 at 64 ug/ml after 24 hrs by XTT assay relative to control | 2020 | Journal of medicinal chemistry, 05-28, Volume: 63, Issue:10 | Discovery of Novel Fungal Lanosterol 14α-Demethylase (CYP51)/Histone Deacetylase Dual Inhibitors to Treat Azole-Resistant Candidiasis. |
| AID420663 | Antifungal activity against Candida tropicalis by micro-broth dilution method | 2009 | European journal of medicinal chemistry, May, Volume: 44, Issue:5 | Design, synthesis, and biological evaluation of novel triazole derivatives as inhibitors of cytochrome P450 14alpha-demethylase. |
| AID1435665 | Antifungal activity against Aspergillus fumigatus 231 after 24 hrs by broth microdilution method | 2017 | European journal of medicinal chemistry, Jan-27, Volume: 126 | S-substituted 3,5-dinitrophenyl 1,3,4-oxadiazole-2-thiols and tetrazole-5-thiols as highly efficient antitubercular agents. |
| AID545718 | Antifungal activity against Trichophyton rubrum after 7 days by serial dilution method | 2010 | European journal of medicinal chemistry, Dec, Volume: 45, Issue:12 | Novel conformationally restricted triazole derivatives with potent antifungal activity. |
| AID1859324 | Antimicrobial activity against Candida albicans SC5314 | 2022 | Journal of medicinal chemistry, 02-24, Volume: 65, Issue:4 | Application of the All-Hydrocarbon Stapling Technique in the Design of Membrane-Active Peptides. |
| AID1886050 | Synergistic antifungal activity against Cryptococcus neoformans clinical isolate 445 assessed as fractional inhibitory concentration index incubated for 72 hrs in presence of P163-0892 by broth microdilution method | |||
| AID1602384 | Antifungal activity against Cryptococcus neoformans H99 infected in ICR mouse assessed as reduction in brain fungal load at 20 mg/kg, po administered daily for 5 days | 2019 | Journal of medicinal chemistry, 03-14, Volume: 62, Issue:5 | Discovery of Carboline Derivatives as Potent Antifungal Agents for the Treatment of Cryptococcal Meningitis. |
| AID519512 | Antifungal activity against Candida glabrata isolates after 48 hrs by CLSI M27-A2 procedure based assay | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | In vitro antifungal activities of isavuconazole (BAL4815), voriconazole, and fluconazole against 1,007 isolates of zygomycete, Candida, Aspergillus, Fusarium, and Scedosporium species. |
| AID118070 | In vivo evaluation of % survival rate after peroral administration on 9th day at dose 0.5 mg/kg | 1995 | Journal of medicinal chemistry, Sep-29, Volume: 38, Issue:20 | Synthesis and antifungal activity of new azole derivatives containing an N-acylmorpholine ring. |
| AID1689217 | Antifungal activity against Candida parapsilosis ATCC 22019 assessed as reduction in fungal growth incubated for 24 hrs by CLSI based broth microdilution method | 2020 | European journal of medicinal chemistry, Mar-01, Volume: 189 | Oxadiazolylthiazoles as novel and selective antifungal agents. |
| AID436744 | Antifungal activity against Microsporum gypseum after 7 days by serial dilution method | 2009 | European journal of medicinal chemistry, Oct, Volume: 44, Issue:10 | New azoles with potent antifungal activity: design, synthesis and molecular docking. |
| AID530933 | Antifungal activity against Candida glabrata ATCC 90030 at 163.3 uM after 48 hrs by CLSI method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Potent in vitro antifungal activities of naturally occurring acetylenic acids. |
| AID582765 | Antifungal activity against Candida albicans isolate 6 assessed as ergosterol content in total sterol composition at 0.5 times MIC by GC-MS analysis | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | Identification and characterization of four azole-resistant erg3 mutants of Candida albicans. |
| AID613740 | Antifungal activity against Cryptococcus neoformans ATCC 34664 by broth dilution method | 2011 | Bioorganic & medicinal chemistry letters, Aug-15, Volume: 21, Issue:16 | Novel hybrids of fluconazole and furanones: design, synthesis and antifungal activity. |
| AID477747 | Antimicrobial activity against Candida parapsilosis ATCC 22019 after 24 hrs | 2010 | European journal of medicinal chemistry, Apr, Volume: 45, Issue:4 | An eco-friendly synthesis and antimicrobial activities of dihydro-2H-benzo- and naphtho-1,3-oxazine derivatives. |
| AID1885982 | Antifungal activity against Candida albicans SC5314 assessed as fungal growth inhibition incubated for 48 hrs in presence of P163-0892 by broth microdilution method | |||
| AID544878 | Antimicrobial activity against Candida dubliniensis harboring MRR1 CD51-2B mutant gene by microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | Gain-of-function mutations in the transcription factor MRR1 are responsible for overexpression of the MDR1 efflux pump in fluconazole-resistant Candida dubliniensis strains. |
| AID1193496 | Thermodynamic equilibrium solubility, log S of the compound in water at RT after 24 hrs by shake-flask method | 2015 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 25, Issue:7 | Thermodynamic equilibrium solubility measurements in simulated fluids by 96-well plate method in early drug discovery. |
| AID582789 | Antifungal activity against Candida albicans isolate 490 harboring ERG3 D147G, T330A, A351V and ERG11 F72S, T229A, E266D, N440S, V488I, R523G mutant genes assessed as lanosterol/obtusifoliol content in total sterol composition at 0.5 times MIC by GC-MS an | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | Identification and characterization of four azole-resistant erg3 mutants of Candida albicans. |
| AID598300 | Antimicrobial activity against Cryptococcus neoformans var. neoformans isolate 14 after 48 hrs by microdilution broth method | 2011 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 21, Issue:11 | Synthesis and in vitro antimicrobial activities of new (cyano-NNO-azoxy)pyrazole derivatives. |
| AID1254318 | Antifungal activity against Candida krusei E28 after 24 hrs by microdilution broth method | 2015 | Bioorganic & medicinal chemistry, Nov-15, Volume: 23, Issue:22 | Novel derivatives of nitro-substituted salicylic acids: Synthesis, antimicrobial activity and cytotoxicity. |
| AID1487477 | Antifungal activity against Aspergillus niger after 24 hrs by well diffusion method | 2017 | Bioorganic & medicinal chemistry letters, 08-15, Volume: 27, Issue:16 | Synthesis, antioxidant, antifungal, molecular docking and ADMET studies of some thiazolyl hydrazones. |
| AID653260 | Antifungal activity against Trichophyton tonsurans after 48 hrs by broth microdilution method | 2012 | Bioorganic & medicinal chemistry, Apr-15, Volume: 20, Issue:8 | Semisynthesis and antimicrobial activity of novel guttiferone-A derivatives. |
| AID1329217 | Antifungal activity against fluconazole-resistant Candida albicans clinical isolate 142 by CLSI broth microdilution method | 2016 | Journal of natural products, 09-23, Volume: 79, Issue:9 | Heptaketides from an Endolichenic Fungus Biatriospora sp. and Their Antifungal Activity. |
| AID367162 | Antimicrobial activity against Candida parapsilosis ATCC 22019 by broth microdilution method | 2009 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 19, Issue:3 | Synthesis and antifungal activity of 1,2,3-triazole containing fluconazole analogues. |
| AID1199858 | Inhibition of recombinant histone acetyltransferase p300 (unknown origin) using dH3-H4 tetramer and [3H]-acetyl-CoA assessed as acetate incorporation after 30 mins by liquid scintillation counting in presence of 1 mM DTT | 2015 | Journal of medicinal chemistry, Mar-12, Volume: 58, Issue:5 | PAINS in the assay: chemical mechanisms of assay interference and promiscuous enzymatic inhibition observed during a sulfhydryl-scavenging HTS. |
| AID598303 | Antimicrobial activity against Cryptococcus neoformans var. neoformans isolate 25 after 48 hrs by microdilution broth method | 2011 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 21, Issue:11 | Synthesis and in vitro antimicrobial activities of new (cyano-NNO-azoxy)pyrazole derivatives. |
| AID520852 | Antifungal activity against Cryptococcus neoformans YC-11 infected in BALB/c mouse assessed as reduction in fungal burden in brain at 20 mg/kg, iv qd for 5 days measured after 7 days of infection | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | Efficacy of SPK-843, a novel polyene antifungal, in a murine model of systemic cryptococcosis. |
| AID644841 | Antifungal activity against Candida krusei DSM 6128 after 48 hrs by M27-A3 CLSI method | 2012 | European journal of medicinal chemistry, Mar, Volume: 49 | Synthesis and antifungal activity of a new series of 2-(1H-imidazol-1-yl)-1-phenylethanol derivatives. |
| AID518427 | Antimicrobial activity against Cryptococcus gattii serotype C isolate H0058-1-1686 assessed as heteroresistant isolates at 2 ug/ml | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Heteroresistance of Cryptococcus gattii to fluconazole. |
| AID555139 | Antimicrobial activity against Candida krusei ATCC 6258 by CLSI M27-A2 broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Fenticonazole activity measured by the methods of the European Committee on Antimicrobial Susceptibility Testing and CLSI against 260 Candida vulvovaginitis isolates from two European regions and annotations on the prevalent genotypes. |
| AID1491243 | Antifungal activity against Cryptococcus neoformans cgmcc 2.3161 by broth microdilution method | 2017 | European journal of medicinal chemistry, Sep-08, Volume: 137 | Design, synthesis and evaluation of aromatic heterocyclic derivatives as potent antifungal agents. |
| AID1585634 | Antifungal activity against fluconazole-resistant Candida albicans isolate g5 cultured in YNB media after 72 hrs by broth microdilution method | 2019 | European journal of medicinal chemistry, Jan-15, Volume: 162 | Chemical preparation, biological evaluation and 3D-QSAR of ethoxysulfuron derivatives as novel antifungal agents targeting acetohydroxyacid synthase. |
| AID1859331 | Antimicrobial activity against Candida auris 918 | 2022 | Journal of medicinal chemistry, 02-24, Volume: 65, Issue:4 | Application of the All-Hydrocarbon Stapling Technique in the Design of Membrane-Active Peptides. |
| AID531538 | Antifungal activity against Candida glabrata clinical isolate obtained from cervicovaginal candidiasis patient assessed as susceptible dose-dependent isolates by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Antifungal resistance of Candida glabrata vaginal isolates and development of a quantitative reverse transcription-PCR-based azole susceptibility assay. |
| AID405029 | Antifungal activity against Sporothrix schenckii MRSS4 isolate from cutaneous-lymphatic sporotrichosis patient after 72 hrs by ATB Fungus 2 method | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | In vitro susceptibility of Sporothrix schenckii to six antifungal agents determined using three different methods. |
| AID407056 | Antimicrobial activity against Candida albicans SC5314 dissociated biofilms grown on silicone-elastomer coated latex surface at cell density of 10'3 cells/ml at 0.25 to 8 ug/ml by XTT assay | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | Role for cell density in antifungal drug resistance in Candida albicans biofilms. |
| AID325037 | Antimicrobial activity against Candida albicans SC5314 after 48 hrs by broth macrodilution method | 2007 | Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5 | A Candida albicans petite mutant strain with uncoupled oxidative phosphorylation overexpresses MDR1 and has diminished susceptibility to fluconazole and voriconazole. |
| AID555814 | Antifungal activity against azole-susceptible Candida albicans 5457 after 48 hrs | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Relative contributions of the Candida albicans ABC transporters Cdr1p and Cdr2p to clinical azole resistance. |
| AID1732417 | Antifungal activity against Candida albicans ATCC 90028 assessed as growth inhibition at 32 ug/ml after 36 hrs by monochromator plate assay relative to control | 2021 | Bioorganic & medicinal chemistry letters, 05-01, Volume: 39 | Design, synthesis and bioactivity evaluation of novel pyrazole linked phenylthiazole derivatives in context of antibacterial activity. |
| AID308602 | Antifungal activity against Candida albicans | 2007 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 17, Issue:15 | Antifungal activity in triterpene glycosides from the sea cucumber Actinopyga lecanora. |
| AID1295326 | Antifungal activity against Cryptococcus neoformans after 48 hrs by broth microdilution method | 2016 | European journal of medicinal chemistry, Jun-10, Volume: 115 | Role of disulfide linkage in action of bis(dialkylaminethiocarbonyl)disulfides as potent double-Edged microbicidal spermicide: Design, synthesis and biology. |
| AID1295975 | Antimicrobial activity against Candida albicans CAF2-1 after 24 hrs by two fold serial dilution method | 2016 | Journal of natural products, Feb-26, Volume: 79, Issue:2 | Antifungal Quinoline Alkaloids from Waltheria indica. |
| AID1360751 | Antifungal activity against Candida albicans MTCC 227 after 48 hrs by serial dilution method | 2018 | European journal of medicinal chemistry, Jul-15, Volume: 155 | Synthesis, crystal structure and antimicrobial potential of some fluorinated chalcone-1,2,3-triazole conjugates. |
| AID613194 | Antifungal activity against Candida albicans ATCC 10231 after 24 hrs by MTT assay | 2011 | European journal of medicinal chemistry, Sep, Volume: 46, Issue:9 | Synthesis and antimicrobial properties of some new thiazolyl coumarin derivatives. |
| AID1392823 | Inhibition of Cyp51 in Candida albicans ATCC SC5314 assessed as lanosterol content at 2 ug/ml after 16 hrs by GC-MS analysis relative to control | 2018 | Bioorganic & medicinal chemistry, 07-23, Volume: 26, Issue:12 | Design, synthesis and evaluation of benzoheterocycle analogues as potent antifungal agents targeting CYP51. |
| AID1419503 | Antifungal activity against Aspergillus flavus ATCC MYA-3631 incubated for 48 hrs by CLSI M38-A2 protocol based method | 2017 | European journal of medicinal chemistry, Jun-16, Volume: 133 | Novel alkylated azoles as potent antifungals. |
| AID294417 | Antifungal activity against Aspergillus oryzae at 25 ug/mL by agar diffusion technique | 2007 | European journal of medicinal chemistry, Jul, Volume: 42, Issue:7 | Synthesis and antimicrobial evaluation of some new thiazole, thiazolidinone and thiazoline derivatives starting from 1-chloro-3,4-dihydronaphthalene-2-carboxaldehyde. |
| AID1494178 | Antifungal activity against fluconazole/ITC-resistant Candida albicans ATCC MYA-1237 measured after 48 hrs by CLSI M27-A3 protocol based method | 2018 | Bioorganic & medicinal chemistry, 02-01, Volume: 26, Issue:3 | Novel fluconazole derivatives with promising antifungal activity. |
| AID340955 | Antifungal activity against Candida krusei isolates from grapes and feeding stuffs by NCCLS M27-A2 method | 2007 | Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8 | Cross-resistance to medical and agricultural azole drugs in yeasts from the oropharynx of human immunodeficiency virus patients and from environmental Bavarian vine grapes. |
| AID553845 | Antifungal activity against Saccharomyces cerevisiae ADCDR2 expressing Candida albicans CDR2 efflux pump in YNPG-proline medium after 24 hrs by microdilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | Enhanced susceptibility to antifungal oligopeptides in yeast strains overexpressing ABC multidrug efflux pumps. |
| AID1239967 | Antifungal activity against Candida utilis ATCC 9950 after 24 hrs by microbroth dilution method | 2015 | Bioorganic & medicinal chemistry letters, Sep-01, Volume: 25, Issue:17 | Design and biological evaluation of novel quinolone-based metronidazole derivatives as potent Cu(2+) mediated DNA-targeting antibacterial agents. |
| AID1472813 | Antifungal activity against Candida albicans ATCC 10231 after 48 hrs by broth dilution method | 2018 | Journal of medicinal chemistry, 01-11, Volume: 61, Issue:1 | Alkylated Piperazines and Piperazine-Azole Hybrids as Antifungal Agents. |
| AID419075 | Antifungal activity against Cryptococcus neoformans TIMM 1855 | 2009 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 19, Issue:7 | Amide analogs of antifungal dioxane-triazole derivatives: synthesis and in vitro activities. |
| AID249259 | Minimum inhibitory concentration to inhibit 50% of the isolates | 2004 | Journal of medicinal chemistry, Jul-29, Volume: 47, Issue:16 | Imidazole analogues of fluoxetine, a novel class of anti-Candida agents. |
| AID415952 | Antimicrobial activity against Candida tropicalis by micro-broth dilution method | 2009 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 19, Issue:6 | Design, synthesis, and biological evaluation of novel 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-substituted benzylamino-2-propanols. |
| AID594128 | Antifungal activity against Candida glabrata ATCC 90030 after 24 hrs | 2011 | European journal of medicinal chemistry, May, Volume: 46, Issue:5 | Pyridine-derived thiosemicarbazones and their tin(IV) complexes with antifungal activity against Candida spp. |
| AID606215 | Antifungal activity against Cryptococcus neoformans ATCC BLS108 after 72 hrs by micro-broth dilution method | 2011 | European journal of medicinal chemistry, Jul, Volume: 46, Issue:7 | Design, synthesis and antifungal activities of novel 1,2,4-triazole derivatives. |
| AID518696 | Antimicrobial activity against Cryptococcus gattii serotype B isolate RAM002 assessed as heteroresistant isolates at 16 ug/ml | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Heteroresistance of Cryptococcus gattii to fluconazole. |
| AID1689213 | Antifungal activity against fluconazole-resistant Candida auris 383 assessed as reduction in fungal growth incubated for 24 hrs by CLSI based broth microdilution method | 2020 | European journal of medicinal chemistry, Mar-01, Volume: 189 | Oxadiazolylthiazoles as novel and selective antifungal agents. |
| AID1783770 | Antifungal activity against Cryptococcus neoformans GIM2.209 assessed as inhibition of fungal growth by NCCLS protocol based method | 2021 | European journal of medicinal chemistry, Nov-15, Volume: 224 | Improving the metabolic stability of antifungal compounds based on a scaffold hopping strategy: Design, synthesis, and structure-activity relationship studies of dihydrooxazole derivatives. |
| AID372240 | Fungistatic activity against wild type Candida albicans CAF2-1 after 24 to 48 hrs by broth microdilution assay | 2007 | Antimicrobial agents and chemotherapy, Oct, Volume: 51, Issue:10 | The Ssk1p response regulator and Chk1p histidine kinase mutants of Candida albicans are hypersensitive to fluconazole and voriconazole. |
| AID1125140 | Antifungal activity against Candida albicans ATCC90028 assessed as growth inhibition by agar serial dilution method | 2014 | European journal of medicinal chemistry, Apr-22, Volume: 77 | Design, synthesis & evaluation of condensed 2H-4-arylaminopyrimidines as novel antifungal agents. |
| AID1392824 | Inhibition of Cyp51 in Candida albicans ATCC SC5314 assessed as lanosterol content at 8 ug/ml after 16 hrs by GC-MS analysis relative to control | 2018 | Bioorganic & medicinal chemistry, 07-23, Volume: 26, Issue:12 | Design, synthesis and evaluation of benzoheterocycle analogues as potent antifungal agents targeting CYP51. |
| AID1370741 | Antifungal activity against Trichophyton rubrum by serial dilution method | 2018 | Bioorganic & medicinal chemistry letters, 02-01, Volume: 28, Issue:3 | Design, synthesis, and structure-activity relationship studies of novel tetrazole antifungal agents with potent activity, broad antifungal spectrum and high selectivity. |
| AID1872533 | Antifungal activity against Microsporum gypseum | 2022 | European journal of medicinal chemistry, Mar-05, Volume: 231 | Synthetic approaches and structural diversity of triazolylbutanols derived from voriconazole in the antifungal drug development. |
| AID440771 | Antifungal activity against Fusarium oxysporum after 24-48 hrs by microdilution susceptibility test | 2009 | European journal of medicinal chemistry, Dec, Volume: 44, Issue:12 | Enaminonitrile in heterocyclic synthesis: synthesis and antimicrobial evaluation of some new pyrazole, isoxazole and pyrimidine derivatives incorporating a benzothiazole moiety. |
| AID467903 | Antifungal activity against Candida albicans after 48 hrs by broth microdilution technique | 2010 | European journal of medicinal chemistry, Feb, Volume: 45, Issue:2 | Imidazole derivatives as possible microbicides with dual protection. |
| AID642938 | Antifungal activity against Candida albicans ATCC 90028 at 160 ug/ml | 2011 | ACS medicinal chemistry letters, May-12, Volume: 2, Issue:5 | Natural Product Based 6-Hydroxy-2,3,4,6-tetrahydropyrrolo[1,2-a]pyrimidinium Scaffold as A New Antifungal Template. |
| AID644832 | Antifungal activity against Candida albicans ATCC 76615 after 48 hrs by M27-A3 CLSI method | 2012 | European journal of medicinal chemistry, Mar, Volume: 49 | Synthesis and antifungal activity of a new series of 2-(1H-imidazol-1-yl)-1-phenylethanol derivatives. |
| AID521787 | Antifungal activity against Candida albicans after 48 hrs by broth microdilution | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | Antimicrobial activity of omiganan pentahydrochloride against contemporary fungal pathogens responsible for catheter-associated infections. |
| AID444056 | Fraction escaping gut-wall elimination in human | 2010 | Journal of medicinal chemistry, Feb-11, Volume: 53, Issue:3 | Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. |
| AID1419475 | Antimicrobial activity against Escherichia coli by two fold serial dilution method | 2017 | European journal of medicinal chemistry, May-05, Volume: 131 | Synthesis and biological evaluation of a new series of benzimidazole derivatives as antimicrobial, antiquorum-sensing and antitumor agents. |
| AID1758002 | Antifungal activity against Candida albicans ATCC SC5314 measured after 24 hrs by broth microdilution assay | 2021 | European journal of medicinal chemistry, Apr-15, Volume: 216 | Lead optimization generates selenium-containing miconazole CYP51 inhibitors with improved pharmacological profile for the treatment of fungal infections. |
| AID29421 | Partition coefficient (logP) (HPLC) | 2000 | Journal of medicinal chemistry, Jul-27, Volume: 43, Issue:15 | ElogPoct: a tool for lipophilicity determination in drug discovery. |
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| AID537528 | Antifungal activity against Candida tropicalis after 48 hrs by broth microdilution method | 2010 | Bioorganic & medicinal chemistry, Nov-15, Volume: 18, Issue:22 | Synthesis of new antifungal peptides selective against Cryptococcus neoformans. |
| AID644830 | Antifungal activity against Candida albicans ATCC 3153 after 48 hrs by M27-A3 CLSI method | 2012 | European journal of medicinal chemistry, Mar, Volume: 49 | Synthesis and antifungal activity of a new series of 2-(1H-imidazol-1-yl)-1-phenylethanol derivatives. |
| AID518895 | Antimicrobial activity against Cryptococcus gattii serotype C isolate H0058-1-1686 assessed as heteroresistant isolates at 32 ug/ml | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Heteroresistance of Cryptococcus gattii to fluconazole. |
| AID619182 | Antifungal activity against Candida tropicalis AN 1946 by broth dilution method | 2011 | Journal of medicinal chemistry, Oct-13, Volume: 54, Issue:19 | High-throughput-screening-based identification and structure-activity relationship characterization defined (S)-2-(1-aminoisobutyl)-1-(3-chlorobenzyl)benzimidazole as a highly antimycotic agent nontoxic to cell lines. |
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| AID1600162 | Antifungal activity against azole-susceptible Candida krusei ATCC 6258 assessed as reduction in fungal growth incubated for 48 hrs by broth microdilution method | 2019 | European journal of medicinal chemistry, Oct-01, Volume: 179 | Discovery of new azoles with potent activity against Candida spp. and Candida albicans biofilms through virtual screening. |
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| AID1726241 | Antifungal activity against Candida auris CBS 10913 by CLSI standard M27 broth microdilution method | |||
| AID388084 | Antifungal activity at Yarrowia lipolytica | 2008 | Bioorganic & medicinal chemistry letters, Oct-15, Volume: 18, Issue:20 | Synthesis of chimeric tetrapeptide-linked cholic acid derivatives: impending synergistic agents. |
| AID532551 | Antifungal activity against Saccharomyces cerevisiae BY4741 harboring human CYP51 assessed as growth rate at 8 ug/ml (Rvb = 0.157%) | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | Differential azole antifungal efficacies contrasted using a Saccharomyces cerevisiae strain humanized for sterol 14 alpha-demethylase at the homologous locus. |
| AID131213 | In vivo activity in Disseminated Murine Candidiasis Model | 2001 | Bioorganic & medicinal chemistry letters, Feb-26, Volume: 11, Issue:4 | Synthesis and biological activity of novel macrocyclic antifungals: acylated conjugates of the ornithine moiety of the lipopeptidolactone FR901469. |
| AID1886087 | Antifungal activity against Cryptococcus neoformans H99 infected in Wax moth larvae assessed as survival rate at 10 mg/kg measured after 9 days in presence of P163-0892 by Kaplan-Meier method | |||
| AID372230 | Effect on MDR1 RNA level in Candida albicans SSK21 at MIC after 120 mins by RT-PCR | 2007 | Antimicrobial agents and chemotherapy, Oct, Volume: 51, Issue:10 | The Ssk1p response regulator and Chk1p histidine kinase mutants of Candida albicans are hypersensitive to fluconazole and voriconazole. |
| AID642917 | Antifungal activity against Candida tropicalis ATCC 750 | 2011 | ACS medicinal chemistry letters, May-12, Volume: 2, Issue:5 | Natural Product Based 6-Hydroxy-2,3,4,6-tetrahydropyrrolo[1,2-a]pyrimidinium Scaffold as A New Antifungal Template. |
| AID1890268 | Antifungal activity against Mucor circinelloides M5 strain assessed as reduction in spore germination at 50 ug/ml relative to control | 2022 | Bioorganic & medicinal chemistry letters, 05-01, Volume: 63 | Novel 2-aryl-4-aryloxyquinoline-based fungistatics for Mucor circinelloides. Biological evaluation of activity, QSAR and docking study. |
| AID1867416 | Antifungal activity against fluconazole resistant Saccharomyces cerevisiae overexpressing CgCdr2p transporter assessed as reduction in fungal growth incubated for 48 hrs by serial dilution method | 2022 | Bioorganic & medicinal chemistry, 06-01, Volume: 63 | Effects of β-lapachone and β-nor-lapachone on multidrug efflux transporters and biofilms of Candida glabrata. |
| AID1918385 | Anti-inflammatory activity in mouse infected with Candida albicans assessed as reduction in IL-6R expression in infection tissues at 20 mg/kg, ip administered on days 2,4,6,8,10,12 and measured on day 14 by western blot analysis | 2022 | Journal of medicinal chemistry, 11-10, Volume: 65, Issue:21 | Novel Aryl Alkamidazole Derivatives as Multifunctional Antifungal Inhibitors: Design, Synthesis, and Biological Evaluation. |
| AID279706 | Increase in antifungal activity against Candida albicans K1 biofilm cells assessed as 50 percent reduction of optical density in presence of beta 1,3 glucanase after 48 hrs by XTT assay | 2007 | Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2 | Putative role of beta-1,3 glucans in Candida albicans biofilm resistance. |
| AID319753 | Antimicrobial activity against Cryptococcus neoformans ATCC 32609 | 2008 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 18, Issue:11 | Synthesis and SAR studies of biaryloxy-substituted triazoles as antifungal agents. |
| AID341592 | Antimicrobial activity against 10'7 CFU Cryptococcus neoformans USC1597 isolate intracranially infected in Hartley guinea pig assessed as decrease in kidney bacterial count at 10 mg/kg, po BID administered 48 hrs postinfection for 13 days | 2007 | Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8 | New guinea pig model of Cryptococcal meningitis. |
| AID518433 | Antimicrobial activity against Cryptococcus gattii serotype B isolate B3939 assessed as heteroresistant isolates at 4 ug/ml | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Heteroresistance of Cryptococcus gattii to fluconazole. |
| AID575761 | Binding affinity to Candida albicans CYP51 | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10 | Expression, purification, and characterization of Aspergillus fumigatus sterol 14-alpha demethylase (CYP51) isoenzymes A and B. |
| AID1369467 | Fungicidal activity against Candida krusei cgmcc 2.1857 after 96 hrs | 2018 | Journal of medicinal chemistry, 05-10, Volume: 61, Issue:9 | Combating Drug-Resistant Fungi with Novel Imperfectly Amphipathic Palindromic Peptides. |
| AID1246669 | Antifungal activity against Cryptococcus gattii 1913ER assessed as reduction in cell viability at 26 uM after 6 to 72 hrs by MTT assay | 2015 | European journal of medicinal chemistry, Sep-18, Volume: 102 | Thiazole compounds with activity against Cryptococcus gattii and Cryptococcus neoformans in vitro. |
| AID1728516 | Inhibition of CYP51 in Candida albicans ATCC SC5314 assessed as eburicol level at 0.5 ug/ml incubated for 48 hrs by LC/MS analysis (Rvb = 1.4 %) | 2021 | European journal of medicinal chemistry, Jan-15, Volume: 210 | Novel naphthylamide derivatives as dual-target antifungal inhibitors: Design, synthesis and biological evaluation. |
| AID518167 | Antimicrobial activity against Cryptococcus gattii serotype C isolate H0058-1-818 assessed as concentration required for heteroresistance | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Heteroresistance of Cryptococcus gattii to fluconazole. |
| AID568492 | Antifungal activity against Aspergillus fumigatus ATCC 96918 by twofold broth dilution method | 2011 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 21, Issue:3 | Synthesis and evaluation of a class of new coumarin triazole derivatives as potential antimicrobial agents. |
| AID622960 | Antifungal activity against Candida albicans ATCC 44859 after 48 hrs by microdilution method | 2011 | Bioorganic & medicinal chemistry letters, Oct-15, Volume: 21, Issue:20 | Synthesis and biological activity of desmethoxy analogues of coruscanone A. |
| AID214423 | In vitro antifungal activity against Trichophyton rubrum | 2003 | Journal of medicinal chemistry, Feb-13, Volume: 46, Issue:4 | Structure-based de novo design, synthesis, and biological evaluation of non-azole inhibitors specific for lanosterol 14alpha-demethylase of fungi. |
| AID352611 | Antifungal activity against Sporothrix schenckii after 72 hrs by micro broth dilution method | 2009 | European journal of medicinal chemistry, Mar, Volume: 44, Issue:3 | 2,3-Disubstituted-1,4-naphthoquinones, 12H-benzo[b]phenothiazine-6,11-diones and related compounds: synthesis and biological evaluation as potential antiproliferative and antifungal agents. |
| AID1246676 | Antifungal activity against Cryptococcus neoformans LMM820 assessed as reduction in cell viability at 26 uM after 6 to 72 hrs by MTT assay | 2015 | European journal of medicinal chemistry, Sep-18, Volume: 102 | Thiazole compounds with activity against Cryptococcus gattii and Cryptococcus neoformans in vitro. |
| AID495357 | Antimicrobial activity against fluconazole susceptible Candida albicans isolate 5052 expressing low levels of ERG11 and UPC2 mRNA by microdilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | An A643T mutation in the transcription factor Upc2p causes constitutive ERG11 upregulation and increased fluconazole resistance in Candida albicans. |
| AID1168338 | Binding affinity to human serum albumin by spectroscopy in presence of Co2+ | 2014 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 24, Issue:21 | Study the interactions between human serum albumin and two antifungal drugs: fluconazole and its analogue DTP. |
| AID1330192 | Antibacterial activity against Pseudomonas aeruginosa 2742 measured after 24 hrs by two-fold serial dilution method | 2016 | Bioorganic & medicinal chemistry letters, 12-15, Volume: 26, Issue:24 | Synthesis and biological evaluation of chalcone derivatives containing aminoguanidine or acylhydrazone moieties. |
| AID1411855 | Antifungal activity against fluconazole susceptible Candida albicans 0079gr by CLSI protocol based broth microdilution method | 2017 | MedChemComm, Dec-01, Volume: 8, Issue:12 | Synergistic antifungal effect of cyclized chalcone derivatives and fluconazole against |
| AID1594995 | Cytotoxicity against African green monkey Vero cells after 72 hrs by plate reader based Alamar blue assay | 2019 | European journal of medicinal chemistry, May-15, Volume: 170 | Evaluation of synthetic substituted 1,2-dioxanes as novel agents against human leishmaniasis. |
| AID386970 | Antimicrobial activity Botrytis fabae at 25 ug/mL after 48 hrs by agar diffusion technique | 2008 | European journal of medicinal chemistry, Oct, Volume: 43, Issue:10 | Synthesis and antimicrobial activity of some new heterocycles incorporating antipyrine moiety. |
| AID582780 | Antifungal activity against Candida albicans isolate 177 assessed as 14alpha-methylergosta-8,24(28)-dien-3beta,6alpha-diol content in total sterol composition at 0.5 times MIC by GC-MS analysis | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | Identification and characterization of four azole-resistant erg3 mutants of Candida albicans. |
| AID1471217 | Antifungal activity against Aspergillus fumigatus by spectrophotometric method | 2017 | Bioorganic & medicinal chemistry letters, 07-01, Volume: 27, Issue:13 | Diversity-oriented sustainable synthesis of antimicrobial spiropyrrolidine/thiapyrrolizidine oxindole derivatives: New ligands for a metallo-β-lactamase from Klebsiella pneumonia. |
| AID1128927 | Antifungal activity against Candida albicans assessed as total growth inhibition by micro-broth dilution method | 2014 | European journal of medicinal chemistry, Apr-09, Volume: 76 | Imidazolylchromanones containing non-benzylic oxime ethers: synthesis and molecular modeling study of new azole antifungals selective against Cryptococcus gattii. |
| AID1478062 | Antimycobacterial activity against Mycobacterium tuberculosis H37Rv after 7 days by resazurin microtiter assay | |||
| AID1427508 | Antifungal activity against Candida albicans MTCC 227 after 48 hrs by broth microdilution method | 2017 | Bioorganic & medicinal chemistry, 03-15, Volume: 25, Issue:6 | Synthesis of 1,3,5-trisubstituted pyrazolines as potential antimalarial and antimicrobial agents. |
| AID653258 | Antifungal activity against Candida tropicalis ATCC 750 after 24 hrs by broth microdilution method | 2012 | Bioorganic & medicinal chemistry, Apr-15, Volume: 20, Issue:8 | Semisynthesis and antimicrobial activity of novel guttiferone-A derivatives. |
| AID1898200 | Inhibition of CYP51 in Candida albicans SC5314 assessed as sterol level at 0.5 ug/ml measured after 12 hrs by GC-MS analysis (Rvb = 25.23%) | |||
| AID405040 | Antifungal activity against Sporothrix schenckii P10012 isolate from cutaneous-lymphatic sporotrichosis patient after 72 hrs by Sensititre YeastOne method | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | In vitro susceptibility of Sporothrix schenckii to six antifungal agents determined using three different methods. |
| AID718385 | Antimicrobial activity against Candida albicans NCIM 3471 by agar diffusion method | 2012 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 22, Issue:23 | POMA analyses as new efficient bioinformatics' platform to predict and optimise bioactivity of synthesized 3a,4-dihydro-3H-indeno[1,2-c]pyrazole-2-carboxamide/carbothioamide analogues. |
| AID428904 | Inhibition of melanin formation in Cryptococcus neoformans ATCC 24067 at 0.25 times MIC coincubated with L-dopa for 7 days by dry-weight measurement | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Voriconazole inhibits melanization in Cryptococcus neoformans. |
| AID518667 | Antimicrobial activity against Cryptococcus gattii serotype B isolate RB3 assessed as heteroresistant isolates at 8 ug/ml | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Heteroresistance of Cryptococcus gattii to fluconazole. |
| AID1242641 | Antibacterial activity against Staphylococcus aureus ATCC 25923 after 16 hrs by microtiter broth dilution method | 2015 | ACS medicinal chemistry letters, Jul-09, Volume: 6, Issue:7 | Novel Chalcone-Thiazole Hybrids as Potent Inhibitors of Drug Resistant Staphylococcus aureus. |
| AID45516 | Inhibitory effect on Candida albicans wild type YEM30 Strain | 2004 | Journal of medicinal chemistry, Jan-01, Volume: 47, Issue:1 | Folate-synthesizing enzyme system as target for development of inhibitors and inhibitor combinations against Candida albicans-synthesis and biological activity of new 2,4-diaminopyrimidines and 4'-substituted 4-aminodiphenyl sulfones. |
| AID1904261 | Antifungal activity against Candida glabrata 9025 assessed as inhibition of fungal growth incubated for 48 hrs by microdilution method | 2022 | Journal of medicinal chemistry, 05-12, Volume: 65, Issue:9 | Discovery of Novel Sertraline Derivatives as Potent Anti- |
| AID48565 | Minimal inhibitory effect against the Candida albicans (4711E). | 2002 | Bioorganic & medicinal chemistry letters, Jul-08, Volume: 12, Issue:13 | Antifungal Sordarins. Part 4: synthesis and structure--activity relationships of 3',4'-fused alkyl-tetrahydrofuran derivatives. |
| AID518424 | Antimicrobial activity against Cryptococcus gattii serotype C isolate NIH298 assessed as heteroresistant isolates at 2 ug/ml | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Heteroresistance of Cryptococcus gattii to fluconazole. |
| AID598887 | Fungicidal activity against Candida albicans SC5314 assessed as concentration required to less than 0.1% survival of organism after 2 hrs | 2011 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 21, Issue:12 | Novel fungicidal benzylsulfanyl-phenylguanidines. |
| AID12307 | Half life of compound determined after intravenous administration to rat | 2002 | Bioorganic & medicinal chemistry letters, Feb-25, Volume: 12, Issue:4 | Design and synthesis of novel benzofurans as a new class of antifungal agents targeting fungal N-myristoyltransferase. Part 2. |
| AID737328 | Antimicrobial activity against Aspergillus niger MTCC 281 at 1000 ug/ml after 72 hrs by cup plate method | 2013 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 23, Issue:7 | Synthesis of novel 2-amino-4-(5'-substituted 2'-phenyl-1H-indol-3'-yl)-6-aryl-4H-pyran-3-carbonitrile derivatives as antimicrobial and antioxidant agents. |
| AID1598018 | Antifungal activity against Trichophyton rubrum after 24 hrs by microbroth dilution method | 2019 | European journal of medicinal chemistry, May-15, Volume: 170 | Current advances of triazole alcohols derived from fluconazole: Design, in vitro and in silico studies. |
| AID424629 | Antimicrobial activity against azole-susceptible Candida albicans isolate CA8 co-treated with calcineurin signaling inhibitor tacrolimus after 48 hrs by microdilution checkerboard technique | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | In vitro interactions between tacrolimus and azoles against Candida albicans determined by different methods. |
| AID1157150 | Antifungal activity against Candida albicans ATCC 76615 after 48 hrs by CLSI broth microdilution method | 2014 | European journal of medicinal chemistry, Aug-18, Volume: 83 | Synthesis, biological evaluation and structure-activity correlation study of a series of imidazol-based compounds as Candida albicans inhibitors. |
| AID1825528 | Anti-Cryptococcal activity against Cryptococcus neoformans infected pneumonia and encephalitis C57BL/6J mouse model assessed as increase in body weight at 8 mg/kg, iv administered once a day for 9 days | 2022 | Journal of medicinal chemistry, 02-10, Volume: 65, Issue:3 | Synthesis of Hemiprotonic Phenanthroline-Phenanthroline |
| AID518681 | Antimicrobial activity against Cryptococcus gattii serotype C isolate H0058-1-1686 assessed as heteroresistant isolates at 8 ug/ml | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Heteroresistance of Cryptococcus gattii to fluconazole. |
| AID1602391 | Induction of cell cycle arrest in Cryptococcus neoformans H99 assessed as accumulation at G1 phase at 4 ug/ml after 24 hrs by propidium iodide-staining based FACS analysis (Rvb = 44.50%) | 2019 | Journal of medicinal chemistry, 03-14, Volume: 62, Issue:5 | Discovery of Carboline Derivatives as Potent Antifungal Agents for the Treatment of Cryptococcal Meningitis. |
| AID1904250 | Fungicidal activity against Cryptococcus neoformans H99 assessed as fungal growth inhibition by measuring colony forming units at 8 ug/ml incubated upto 72 hrs by time-fungicidal curve assay | 2022 | Journal of medicinal chemistry, 05-12, Volume: 65, Issue:9 | Discovery of Novel Sertraline Derivatives as Potent Anti- |
| AID424898 | Antimicrobial activity against azole-resistant Candida albicans isolate CA10 assessed as growth at 128 ug/ml cotreated with 0.016 ug/ml calcineurin signaling inhibitor tacrolimus after 48 hrs by microdilution checkerboard technique relative to control | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | In vitro interactions between tacrolimus and azoles against Candida albicans determined by different methods. |
| AID208220 | Inhibition of Trichosporon beigelli 1188 for 48 hours in vitro. | 2001 | Journal of medicinal chemistry, Aug-16, Volume: 44, Issue:17 | 3-Phenyl-5-acyloxymethyl-2H,5H-furan-2-ones: synthesis and biological activity of a novel group of potential antifungal drugs. |
| AID518891 | Antimicrobial activity against Cryptococcus gattii serotype C isolate NIH191 assessed as heteroresistant isolates at 32 ug/ml | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Heteroresistance of Cryptococcus gattii to fluconazole. |
| AID1885976 | Antifungal activity against Cryptococcus gattii clinical isolate SCZ20024 assessed as fungal growth inhibition incubated for 72 hrs by broth microdilution method | |||
| AID1196810 | Binding affinity to recombinant full-length Trypanosoma cruzi CYP51 by UV-spectrophotometric analysis | 2015 | Journal of medicinal chemistry, Feb-12, Volume: 58, Issue:3 | Novel 3-nitrotriazole-based amides and carbinols as bifunctional antichagasic agents. |
| AID301019 | Antifungal activity against Candida krusei GO3 at 250 ug/ml after 48 hrs by agar well diffusion technique | 2007 | Bioorganic & medicinal chemistry letters, Oct-01, Volume: 17, Issue:19 | Synthesis and antimicrobial evaluation of new chalcones containing piperazine or 2,5-dichlorothiophene moiety. |
| AID42683 | In vitro antifungal activity against Candida glabrata 2375E | 2002 | Journal of medicinal chemistry, Oct-24, Volume: 45, Issue:22 | Synthesis, antifungal activity, and molecular modeling studies of new inverted oxime ethers of oxiconazole. |
| AID521977 | Antibacterial activity against Fluconazole resistant Candida albicans DSY296 overexpressing multidrug transporter gene CDR1 and CDR2 and containing ERG11 G464S mutation containing CIp10 to restore URA3 function infected in BALB/c mouse assessed as effect | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Genetic dissection of azole resistance mechanisms in Candida albicans and their validation in a mouse model of disseminated infection. |
| AID555136 | Antimicrobial activity against Candida albicans by CLSI M27-A2 broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Fenticonazole activity measured by the methods of the European Committee on Antimicrobial Susceptibility Testing and CLSI against 260 Candida vulvovaginitis isolates from two European regions and annotations on the prevalent genotypes. |
| AID174690 | In vivo evaluation of antifungal activity against vaginal candidosis in rat at dose 0.5 mg/kg on 10th day | 1995 | Journal of medicinal chemistry, Sep-29, Volume: 38, Issue:20 | Synthesis and antifungal activity of new azole derivatives containing an N-acylmorpholine ring. |
| AID434892 | Antifungal activity against Candida tropicalis isolate 4 in RPMI 1640 medium by broth dilution susceptibility test | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | In vitro study of Candida tropicalis isolates exhibiting paradoxical growth in the presence of high concentrations of caspofungin. |
| AID1190607 | Antimicrobial activity against Pseudomonas aeruginosa ATCC 10145 assessed as inhibition of microbial growth incubated for 24 hrs by broth dilution method | 2015 | Bioorganic & medicinal chemistry letters, Feb-15, Volume: 25, Issue:4 | Synthesis, antimicrobial activity and molecular docking of novel tetracyclic scaffolds incorporating a flavonoid framework with medium sized oxygen heterocycles. |
| AID1435659 | Antifungal activity against Candida krusei E28 after 24 hrs by broth microdilution method | 2017 | European journal of medicinal chemistry, Jan-27, Volume: 126 | S-substituted 3,5-dinitrophenyl 1,3,4-oxadiazole-2-thiols and tetrazole-5-thiols as highly efficient antitubercular agents. |
| AID1594996 | Selectivity index, ratio of CC50 for African green monkey Vero cells to IC50 for Leishmania donovani MHOM/NP/02/BPK282/0c14 | 2019 | European journal of medicinal chemistry, May-15, Volume: 170 | Evaluation of synthetic substituted 1,2-dioxanes as novel agents against human leishmaniasis. |
| AID118072 | In vivo evaluation of % survival rate after peroral administration on 9th day at dose 1 mg/kg | 1995 | Journal of medicinal chemistry, Sep-29, Volume: 38, Issue:20 | Synthesis and antifungal activity of new azole derivatives containing an N-acylmorpholine ring. |
| AID1302228 | Antifungal activity against fluconazole-susceptible Candida albicans ATCC 90028 in immunocompetent Balb/c mouse candidiasis model assessed as reduction in CFU count in spleen at 8 mg/kg/day, ip regime measured on day 7 post infection | 2016 | Journal of medicinal chemistry, 04-28, Volume: 59, Issue:8 | Biological Characterization and in Vivo Assessment of the Activity of a New Synthetic Macrocyclic Antifungal Compound. |
| AID1304742 | Antifungal activity against Trichophyton mentagrophytes measured after 7 days by serial dilution method | 2016 | Journal of medicinal chemistry, Apr-14, Volume: 59, Issue:7 | Discovery of Potent Benzofuran-Derived Diapophytoene Desaturase (CrtN) Inhibitors with Enhanced Oral Bioavailability for the Treatment of Methicillin-Resistant Staphylococcus aureus (MRSA) Infections. |
| AID283225 | Prolongation of survival in CD1 mouse infected with Coccidioides immitis Silveira administered after 3 days of infection at 50 mg/kg, po bid after 12 days relative to control | 2007 | Antimicrobial agents and chemotherapy, Mar, Volume: 51, Issue:3 | Comparison of itraconazole and fluconazole treatments in a murine model of coccidioidal meningitis. |
| AID499662 | Antimicrobial activity against Candida glabrata IFO 0622 by microdilution assay | 2010 | Bioorganic & medicinal chemistry, Aug-15, Volume: 18, Issue:16 | Novel antifungal agents: triazolopyridines as inhibitors of beta-1,6-glucan synthesis. |
| AID495361 | Antimicrobial activity against Candida albicans isolate SC5314 expressing UPC2 G648D/UPC2 A643T double mutant alleles by microdilution method relative wild type | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | An A643T mutation in the transcription factor Upc2p causes constitutive ERG11 upregulation and increased fluconazole resistance in Candida albicans. |
| AID1484710 | Antileishmanial activity against Leishmania (Viannia) braziliensis infected in human assessed as cure rate at 5 to 8 mg/kg/day, po for 4 weeks | 2017 | European journal of medicinal chemistry, Jul-28, Volume: 135 | An overview of azoles targeting sterol 14α-demethylase for antileishmanial therapy. |
| AID704466 | Antifungal activity against Candida albicans SC 53124 after 24 hrs by NCCLS broth microdilution method | 2012 | ACS medicinal chemistry letters, Oct-11, Volume: 3, Issue:10 | Antifungal spectrum, in vivo efficacy, and structure-activity relationship of ilicicolin h. |
| AID574612 | Antifungal activity against Trichosporon beigelii 1188 after 48 hrs by broth microdilution method | 2011 | Bioorganic & medicinal chemistry, Feb-15, Volume: 19, Issue:4 | Synthesis and antimycobacterial properties of N-substituted 6-amino-5-cyanopyrazine-2-carboxamides. |
| AID582809 | Antifungal activity against Candida albicans isolate 1008 harboring ERG3 K97E, L193P, V237A, A351V, A353T and ERG11 E266D mutant genes by broth microdilution method in presence of 10 uM drug efflux inhibitor FK506 | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | Identification and characterization of four azole-resistant erg3 mutants of Candida albicans. |
| AID1392810 | Antifungal activity against Candida tropicalis cgmcc 2.3739 after 24 hrs by serial dilution method | 2018 | Bioorganic & medicinal chemistry, 07-23, Volume: 26, Issue:12 | Design, synthesis and evaluation of benzoheterocycle analogues as potent antifungal agents targeting CYP51. |
| AID736600 | Antifungal activity against anidulafungin-resistant Candida parapsilosis ANF8 assessed as growth inhibition after 24 to 48 hrs by CLSI microbroth dilution method | 2013 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 23, Issue:6 | Synthesis and anti-Candida activity of novel 2-hydrazino-1,3-thiazole derivatives. |
| AID1822495 | Antifungal activity against Candida parapsilosis ATCC 22019 assessed as reduction in drug tolerance by measuring zone of inhibition at 25 ug incubated for 24 to 48 hrs by disk diffusion assay | 2022 | Journal of medicinal chemistry, 02-10, Volume: 65, Issue:3 | Fluconazole-COX Inhibitor Hybrids: A Dual-Acting Class of Antifungal Azoles. |
| AID1312610 | Antifungal activity against naftifine-sensitive Trichophyton verrucosum after 7 days by serial dilution method | 2016 | Journal of medicinal chemistry, 05-26, Volume: 59, Issue:10 | Discovery of Benzocycloalkane Derivatives Efficiently Blocking Bacterial Virulence for the Treatment of Methicillin-Resistant S. aureus (MRSA) Infections by Targeting Diapophytoene Desaturase (CrtN). |
| AID257546 | Antifungal activity against Sporothrix schenckii | 2005 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 15, Issue:23 | Synthesis and biological evaluation of novel (L)-alpha-amino acid methyl ester, heteroalkyl, and aryl substituted 1,4-naphthoquinone derivatives as antifungal and antibacterial agents. |
| AID1235434 | Antifungal activity against clinical isolates of Candida tropicalis 2029 by broth microdilution assay | 2015 | Bioorganic & medicinal chemistry, Aug-01, Volume: 23, Issue:15 | Imidazole clubbed 1,3,4-oxadiazole derivatives as potential antifungal agents. |
| AID1624193 | Antibiofilm activity against 48 hrs old pre-formed biofilms of Candida albicans ATCC 10231 at 16 ug/ml after 24 hrs by MTS assay relative to control | 2019 | Bioorganic & medicinal chemistry letters, 03-01, Volume: 29, Issue:5 | Benzimidazole tethered pyrrolo[3,4-b]quinoline with broad-spectrum activity against fungal pathogens. |
| AID1370738 | Antifungal activity against Candida glabrata after 24 hrs by serial dilution method | 2018 | Bioorganic & medicinal chemistry letters, 02-01, Volume: 28, Issue:3 | Design, synthesis, and structure-activity relationship studies of novel tetrazole antifungal agents with potent activity, broad antifungal spectrum and high selectivity. |
| AID1491262 | Inhibition of CYP51 in Candida albicans ATCC SC5314 assessed as lanosterol content at 0.5 ug/ml by GS-MS analysis relative to total sterols | 2017 | European journal of medicinal chemistry, Sep-08, Volume: 137 | Design, synthesis and evaluation of aromatic heterocyclic derivatives as potent antifungal agents. |
| AID1411853 | Antifungal activity against fluconazole susceptible Candida albicans 004gr by CLSI protocol based broth microdilution method | 2017 | MedChemComm, Dec-01, Volume: 8, Issue:12 | Synergistic antifungal effect of cyclized chalcone derivatives and fluconazole against |
| AID1905337 | Induction of morphological changes in Candida albicans 904 assessed as hyphal formation by measuring EFG1 level incubated for 4 hrs | 2022 | Journal of medicinal chemistry, 04-14, Volume: 65, Issue:7 | Species-Selective Targeting of Fungal Hsp90: Design, Synthesis, and Evaluation of Novel 4,5-Diarylisoxazole Derivatives for the Combination Treatment of Azole-Resistant Candidiasis. |
| AID424639 | Antimicrobial activity against azole-resistant Candida albicans isolate CA10 assessed as growth at 0.25 ug/ml cotreated with 0.125 ug/ml calcineurin signaling inhibitor Tacrolimus after 48 hrs by microdilution checkboard technique relative to control | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | In vitro interactions between tacrolimus and azoles against Candida albicans determined by different methods. |
| AID1168347 | Ratio of binding constant for human serum albumin in presence of Cu2+ to binding constant for human serum albumin in absence of metal ions | 2014 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 24, Issue:21 | Study the interactions between human serum albumin and two antifungal drugs: fluconazole and its analogue DTP. |
| AID499656 | Solubility of the compound at pH 6.8 | 2010 | Bioorganic & medicinal chemistry, Aug-15, Volume: 18, Issue:16 | Novel antifungal agents: triazolopyridines as inhibitors of beta-1,6-glucan synthesis. |
| AID519063 | Antifungal activity against Candida krusei assessed as resistant isolates after 48 hrs by broth microdilution | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | Antimicrobial activity of omiganan pentahydrochloride against contemporary fungal pathogens responsible for catheter-associated infections. |
| AID1600173 | Antifungal activity against Rhodotorula glutinis NCIM 3168 assessed as inhibition of fungal growth incubated for 48 to 72 hrs by broth microdilution susceptibility method | 2019 | European journal of medicinal chemistry, Oct-01, Volume: 179 | Synthesis of new thiazolyl-pyrazolyl-1,2,3-triazole derivatives as potential antimicrobial agents. |
| AID1888271 | Induction of apoptosis in Candida albicans ATCC SC5314 cells assessed as late apoptotic cells at 8 ug/ml incubated for 72 hrs by Annexin V-FITC/PI staining based flow cytometry method (Rvb = 0.12%) | |||
| AID603348 | Antifungal activity against Aspergillus fumigatus clinical isolate by micro-broth dilution method | 2011 | European journal of medicinal chemistry, Jul, Volume: 46, Issue:7 | Design, synthesis and molecular docking studies of novel triazole as antifungal agent. |
| AID535684 | Antibacterial activity against Cryptococcus gattii after 72 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Antifungal susceptibilities among different serotypes of Cryptococcus gattii and Cryptococcus neoformans. |
| AID1279031 | Antifungal activity against Absidia corymbifera 272 after 24 hrs by microbroth dilution method | 2016 | Bioorganic & medicinal chemistry, Mar-15, Volume: 24, Issue:6 | Salicylanilide N-monosubstituted carbamates: Synthesis and in vitro antimicrobial activity. |
| AID1818291 | Inhibition of SE/CYP51 in Candida albicans ATCC SC5314 assessed as unknown sterol level incubated for 48 hrs by LC/MS analysis (Rvb = 4.3 %) | |||
| AID425140 | Antimicrobial activity against azole-resistant Candida albicans isolate CA10 assessed as growth at 1 ug/ml after 48 hrs by microdilution checkerboard technique relative to control | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | In vitro interactions between tacrolimus and azoles against Candida albicans determined by different methods. |
| AID1770963 | Cytotoxicity against human MCF7 cells assessed as reduction in cell viability measured after 96 hrs by MTT assay | 2021 | European journal of medicinal chemistry, Dec-05, Volume: 225 | Design, synthesis and evaluation of novel 5-phenylthiophene derivatives as potent fungicidal of Candida albicans and antifungal reagents of fluconazole-resistant fungi. |
| AID1885988 | Antifungal activity against Cryptococcus neoformans clinical isolate 56992 assessed as fungal growth inhibition incubated for 72 hrs in presence of P163-0892 by broth microdilution method | |||
| AID1728457 | Antifungal activity against Candida albicans ATCC 10231 assessed as inhibition of microbial growth by NCCLS protocol based method | 2021 | European journal of medicinal chemistry, Jan-15, Volume: 210 | Novel naphthylamide derivatives as dual-target antifungal inhibitors: Design, synthesis and biological evaluation. |
| AID554709 | Antimicrobial activity against Candida krusei NZCDC 89.221 after 48 hrs by liquid microdilution assay | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Abc1p is a multidrug efflux transporter that tips the balance in favor of innate azole resistance in Candida krusei. |
| AID37847 | Inhibition of Aspergillus fumigatus 231 growth for 24 hours in vitro. | 2001 | Journal of medicinal chemistry, Aug-16, Volume: 44, Issue:17 | 3-Phenyl-5-acyloxymethyl-2H,5H-furan-2-ones: synthesis and biological activity of a novel group of potential antifungal drugs. |
| AID521527 | Antifungal activity against Candida albicans ATCC MYA-575 after 47 hrs by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | In vitro and in vivo antifungal activities of T-2307, a novel arylamidine. |
| AID420665 | Antifungal activity against Candida krusei by micro-broth dilution method | 2009 | European journal of medicinal chemistry, May, Volume: 44, Issue:5 | Design, synthesis, and biological evaluation of novel triazole derivatives as inhibitors of cytochrome P450 14alpha-demethylase. |
| AID469167 | Antifungal activity against Candida albicans | 2010 | European journal of medicinal chemistry, Feb, Volume: 45, Issue:2 | Synthesis, anti-bacterial and anti-fungal activities of some novel Schiff bases containing 2,4-disubstituted thiazole ring. |
| AID575760 | Binding affinity to Mycobacterium smegmatis CYP51 | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10 | Expression, purification, and characterization of Aspergillus fumigatus sterol 14-alpha demethylase (CYP51) isoenzymes A and B. |
| AID1809926 | Induction of drug resistance in Candida glabrata BG2 assessed as increase in FCZ IC50 at 8 times IC50 after 23 days | 2021 | Journal of medicinal chemistry, 11-11, Volume: 64, Issue:21 | Optimization and Evaluation of Novel Antifungal Agents for the Treatment of Fungal Infection. |
| AID351030 | Antimicrobial activity against Candida glabrata by broth microdilution method | 2009 | European journal of medicinal chemistry, Mar, Volume: 44, Issue:3 | 2-Acylhydrazino-5-arylpyrrole derivatives: synthesis and antifungal activity evaluation. |
| AID1126883 | Antifungal activity against Candida parapsilosis ATCC 22019 assessed as growth inhibition after 18 hrs by two-fold serial dilution method | 2014 | European journal of medicinal chemistry, May-06, Volume: 78 | Searching for new derivatives of neocryptolepine: synthesis, antiproliferative, antimicrobial and antifungal activities. |
| AID1154838 | Antifungal activity against fluconazole-resistant Candida albicans 805 after 24 hrs by serial dilution method | 2014 | ACS medicinal chemistry letters, May-08, Volume: 5, Issue:5 | Novel carboline derivatives as potent antifungal lead compounds: design, synthesis, and biological evaluation. |
| AID1295981 | Antibiofilm activity against Candida albicans CAF2-1 assessed as reduction in metabolic activity after 48 hrs by XTT assay | 2016 | Journal of natural products, Feb-26, Volume: 79, Issue:2 | Antifungal Quinoline Alkaloids from Waltheria indica. |
| AID567091 | Drug absorption in human assessed as human intestinal absorption rate | 2011 | European journal of medicinal chemistry, Jan, Volume: 46, Issue:1 | Prediction of drug intestinal absorption by new linear and non-linear QSPR. |
| AID518161 | Antimicrobial activity against Cryptococcus gattii serotype C isolate NIH18 assessed as concentration required for heteroresistance | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Heteroresistance of Cryptococcus gattii to fluconazole. |
| AID1281699 | Antifungal activity against Candida albicans ATCC 10231 after 24 hrs by micro broth dilution method | 2016 | European journal of medicinal chemistry, Mar-23, Volume: 111 | Discovery of membrane active benzimidazole quinolones-based topoisomerase inhibitors as potential DNA-binding antimicrobial agents. |
| AID301285 | Antifungal activity against Candida albicans MTCC 183 after 48 hrs by broth micro dilution technique | 2007 | Bioorganic & medicinal chemistry, Nov-01, Volume: 15, Issue:21 | Synthesis of disulfide esters of dialkylaminocarbothioic acid as potent, non-detergent spermicidal agents. |
| AID420084 | Antifungal activity against Candida albicans CA-6 infected in CD1 mouse assessed as reduction fungal cell number in kidney at 10 mg/kg, ip pretreated 2 hrs before fungus-challenge and once daily for 6 days measured 7 days post-infection by periodic acid-S | 2009 | Bioorganic & medicinal chemistry, Jun-01, Volume: 17, Issue:11 | Bulky 1,4-benzoxazine derivatives with antifungal activity. |
| AID616567 | Antifungal activity against Candida albicans CaCi-8 clinical isolate | 2011 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 21, Issue:18 | Piperazinyl quinolines as chemosensitizers to increase fluconazole susceptibility of Candida albicans clinical isolates. |
| AID1168342 | Binding affinity to human serum albumin by spectroscopy in presence of La3+ | 2014 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 24, Issue:21 | Study the interactions between human serum albumin and two antifungal drugs: fluconazole and its analogue DTP. |
| AID278381 | Antifungal activity against Candida lusitaniae 6936 URA3[D95V] derived null mutant fcy2delta::URA3 by microdilution assay | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Molecular mechanism of flucytosine resistance in Candida lusitaniae: contribution of the FCY2, FCY1, and FUR1 genes to 5-fluorouracil and fluconazole cross-resistance. |
| AID262556 | Antifungal activity against Microsporum lanosum | 2006 | Journal of medicinal chemistry, Apr-20, Volume: 49, Issue:8 | Structure-based optimization of azole antifungal agents by CoMFA, CoMSIA, and molecular docking. |
| AID582223 | Antifungal activity against Candida albicans isolated from HSCT recipients with acute or chronic GVHD receiving posaconazole assessed as maximum MIC by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Impact of antifungal prophylaxis on colonization and azole susceptibility of Candida species. |
| AID521534 | Antifungal activity against Candida parapsilosis clinical isolates after 48 hrs by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | In vitro and in vivo antifungal activities of T-2307, a novel arylamidine. |
| AID1556209 | Antifungal activity against Candida albicans ATCC SC5314 assessed as inhibition of visible microbial growth by NCCLS protocol based method | 2019 | European journal of medicinal chemistry, Sep-01, Volume: 177 | Design, synthesis, and structure-activity relationship studies of l-amino alcohol derivatives as broad-spectrum antifungal agents. |
| AID1905290 | Fungicidal activity against Candida albicans 904 assessed as colony forming at 4 times MIC incubated for 48 hrs by time-kill curve assay | 2022 | Journal of medicinal chemistry, 04-14, Volume: 65, Issue:7 | Species-Selective Targeting of Fungal Hsp90: Design, Synthesis, and Evaluation of Novel 4,5-Diarylisoxazole Derivatives for the Combination Treatment of Azole-Resistant Candidiasis. |
| AID1076263 | Antibacterial activity against Bacillus subtilis assessed as growth inhibition by microdilution broth susceptibility assay | 2014 | European journal of medicinal chemistry, Mar-21, Volume: 75 | Synthesis, docking and evaluation of antioxidant and antimicrobial activities of novel 1,2,4-triazolo[3,4-b][1,3,4]thiadiazol-6-yl)selenopheno[2,3-d]pyrimidines. |
| AID642940 | Antifungal activity against fluconazole-resistant Candida albicans isolate 1 isolated from AIDS patient at 160 ug/ml | 2011 | ACS medicinal chemistry letters, May-12, Volume: 2, Issue:5 | Natural Product Based 6-Hydroxy-2,3,4,6-tetrahydropyrrolo[1,2-a]pyrimidinium Scaffold as A New Antifungal Template. |
| AID352319 | Antimicrobial activity against Escherichia coli at 37 degC after 24 hrs by tube dilution method | 2009 | European journal of medicinal chemistry, Mar, Volume: 44, Issue:3 | Synthesis and QSAR evaluation of 2-(substituted phenyl)-1H-benzimidazoles and [2-(substituted phenyl)-benzimidazol-1-yl]-pyridin-3-yl-methanones. |
| AID1728510 | Inhibition of CYP51 in Candida albicans ATCC SC5314 assessed as ergosterol level at 4 ug/ml incubated for 48 hrs by LC/MS analysis (Rvb = 95.1 %) | 2021 | European journal of medicinal chemistry, Jan-15, Volume: 210 | Novel naphthylamide derivatives as dual-target antifungal inhibitors: Design, synthesis and biological evaluation. |
| AID1392812 | Inhibition of Cyp51 in Candida albicans ATCC SC5314 assessed as ergosterol content at 0.03125 ug/ml after 16 hrs by GC-MS analysis (Rvb = 98.7%) | 2018 | Bioorganic & medicinal chemistry, 07-23, Volume: 26, Issue:12 | Design, synthesis and evaluation of benzoheterocycle analogues as potent antifungal agents targeting CYP51. |
| AID1474175 | Inhibition of CYP51 in Candida albicans ATCC SC5314 assessed as ergosterol composition of the total sterol fraction in membrane at 8 ug/ml after 16 hrs by GC-MS analysis (Rvb = 89.6%) | 2016 | European journal of medicinal chemistry, Nov-10, Volume: 123 | Design, synthesis, and structure-activity relationship studies of benzothiazole derivatives as antifungal agents. |
| AID1355743 | In vivo antifungal activity against FLC resistant Candida albicans 0304103 infected in ICR mouse assessed as mouse survival at 1 mg/kg, ip qd up to 20 days (Rvb = 4.5 day) | 2018 | Journal of medicinal chemistry, Jul-26, Volume: 61, Issue:14 | Discovery of Janus Kinase 2 (JAK2) and Histone Deacetylase (HDAC) Dual Inhibitors as a Novel Strategy for the Combinational Treatment of Leukemia and Invasive Fungal Infections. |
| AID285866 | Antimicrobial susceptibility of Pichia anomala from nosocomial fungemia patient assessed as percent susceptible isolates at 0.12 ug/ml by EUCAST method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Antifungal drug susceptibility profile of Pichia anomala isolates from patients presenting with nosocomial fungemia. |
| AID47389 | In vitro antifungal activity against Candida albicans ATCC 90028 | 2004 | Bioorganic & medicinal chemistry letters, Jan-05, Volume: 14, Issue:1 | Novel galbonolide derivatives as IPC synthase inhibitors: design, synthesis and in vitro antifungal activities. |
| AID655718 | Antifungal activity against Trichoderma viride MTCC 1107 at 160 uM/ml after 48 hrs by paper disc diffusion method | 2012 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 22, Issue:8 | Design, synthesis, synergistic antimicrobial activity and cytotoxicity of 4-aryl substituted 3,4-dihydropyrimidinones of curcumin. |
| AID581883 | Antifungal activity against Candida glabrata isolated from HSCT recipient 975 with acute or chronic GVHD mouth receiving antifungal drug after 112 days prophylaxis by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Impact of antifungal prophylaxis on colonization and azole susceptibility of Candida species. |
| AID757546 | Anticandida activity against Candida sake clinical isolate assessed as growth inhibition after 24 hrs by broth microdilution method | 2013 | European journal of medicinal chemistry, Jul, Volume: 65 | Synthesis and cytotoxicity of novel (thiazol-2-yl)hydrazine derivatives as promising anti-Candida agents. |
| AID1598041 | Antifungal activity against Candida parapsilosis after 24 hrs | 2019 | European journal of medicinal chemistry, May-15, Volume: 170 | Current advances of triazole alcohols derived from fluconazole: Design, in vitro and in silico studies. |
| AID1770933 | Anti-biofilm activity in Candida albicans CPCC400616 assessed as inhibition of biofilm formation incubated for 24 hrs by XTT assay | 2021 | European journal of medicinal chemistry, Dec-05, Volume: 225 | Design, synthesis and evaluation of novel 5-phenylthiophene derivatives as potent fungicidal of Candida albicans and antifungal reagents of fluconazole-resistant fungi. |
| AID27580 | Partition coefficient (logP) | 2000 | Journal of medicinal chemistry, Jul-27, Volume: 43, Issue:15 | ElogPoct: a tool for lipophilicity determination in drug discovery. |
| AID518882 | Antimicrobial activity against Cryptococcus gattii serotype B isolate NIH771 assessed as heteroresistant isolates at 32 ug/ml | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Heteroresistance of Cryptococcus gattii to fluconazole. |
| AID42885 | Inhibition of Candida parapsilosis ATCC 22019 growth for 48 hours in vitro. | 2001 | Journal of medicinal chemistry, Aug-16, Volume: 44, Issue:17 | 3-Phenyl-5-acyloxymethyl-2H,5H-furan-2-ones: synthesis and biological activity of a novel group of potential antifungal drugs. |
| AID574606 | Antifungal activity against Trichophyton mentagrophytes 445 after 72 hrs by broth microdilution method | 2011 | Bioorganic & medicinal chemistry, Feb-15, Volume: 19, Issue:4 | Synthesis and antimycobacterial properties of N-substituted 6-amino-5-cyanopyrazine-2-carboxamides. |
| AID637217 | Antifungal activity against Aspergillus niger MTCC 8189 after 7 days by tube dilution method hrs followed by subculturing | 2012 | European journal of medicinal chemistry, Feb, Volume: 48 | Synthesis, antimicrobial, anticancer evaluation and QSAR studies of 6-methyl-4-[1-(2-substituted-phenylamino-acetyl)-1H-indol-3-yl]-2-oxo/thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid ethyl esters. |
| AID1076262 | Antibacterial activity against Klebsiella pneumoniae assessed as growth inhibition by microdilution broth susceptibility assay | 2014 | European journal of medicinal chemistry, Mar-21, Volume: 75 | Synthesis, docking and evaluation of antioxidant and antimicrobial activities of novel 1,2,4-triazolo[3,4-b][1,3,4]thiadiazol-6-yl)selenopheno[2,3-d]pyrimidines. |
| AID1888275 | Antifungal activity against Candida albicans ATCC SC5314 assessed as change in eburicol level at 4 ug/ml incubated for 48 hrs by LC-MS analysis (Rvb = 1.4%) | |||
| AID622970 | Antifungal activity against Candida tropicalis 156 after 48 hrs by microdilution method | 2011 | Bioorganic & medicinal chemistry letters, Oct-15, Volume: 21, Issue:20 | Synthesis and biological activity of desmethoxy analogues of coruscanone A. |
| AID518651 | Antimicrobial activity against Cryptococcus gattii serotype C isolate H0058-1-1686 assessed as heteroresistant isolates at 4 ug/ml | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Heteroresistance of Cryptococcus gattii to fluconazole. |
| AID48615 | Evaluation of In vitro antifungal activity against Candida tropicalis 50 by broth macro dilution method | 1995 | Journal of medicinal chemistry, Sep-29, Volume: 38, Issue:20 | Synthesis and antifungal activity of new azole derivatives containing an N-acylmorpholine ring. |
| AID1474178 | Inhibition of CYP51 in Candida albicans ATCC SC5314 assessed as eburicol composition of the total sterol fraction in membrane at 8 ug/ml after 16 hrs by GC-MS analysis relative to control | 2016 | European journal of medicinal chemistry, Nov-10, Volume: 123 | Design, synthesis, and structure-activity relationship studies of benzothiazole derivatives as antifungal agents. |
| AID619592 | Antifungal activity against Candida albicans CAF-2 after 24 hrs by broth microdilution method | 2011 | Bioorganic & medicinal chemistry, Oct-01, Volume: 19, Issue:19 | Antifungal activity of a series of 1,2-benzisothiazol-3(2H)-one derivatives. |
| AID118055 | In vivo evaluation of % survival rate after peroral administration on 5th day at dose 0.5 mg/kg | 1995 | Journal of medicinal chemistry, Sep-29, Volume: 38, Issue:20 | Synthesis and antifungal activity of new azole derivatives containing an N-acylmorpholine ring. |
| AID1494155 | Antifungal activity against Candida albicans SC5314 infected in ICR mouse assessed as increase in host survival at 1 mg/kg, po qd for 7 days starting from 2 hrs post infection measured up to 20 days | 2018 | European journal of medicinal chemistry, Jan-01, Volume: 143 | Molecular docking, design, synthesis and antifungal activity study of novel triazole derivatives. |
| AID547612 | Antifungal activity against Candida glabrata isolate Cg13S | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | Microarray and molecular analyses of the azole resistance mechanism in Candida glabrata oropharyngeal isolates. |
| AID1330187 | Antibacterial activity against Staphylococcus aureus 209 measured after 24 hrs by two-fold serial dilution method | 2016 | Bioorganic & medicinal chemistry letters, 12-15, Volume: 26, Issue:24 | Synthesis and biological evaluation of chalcone derivatives containing aminoguanidine or acylhydrazone moieties. |
| AID118067 | In vivo evaluation of % survival rate after peroral administration on 7th day at dose 20 mg/kg | 1995 | Journal of medicinal chemistry, Sep-29, Volume: 38, Issue:20 | Synthesis and antifungal activity of new azole derivatives containing an N-acylmorpholine ring. |
| AID609968 | Antifungal activity against Aspergillus niger at 1000 ug after 24 hrs by paper disc technique | 2011 | Bioorganic & medicinal chemistry letters, Aug-15, Volume: 21, Issue:16 | Efficient synthesis of antifungal active 9-substituted-3-aryl-5H,13aH-quinolino[3,2-f][1,2,4]triazolo[4,3-b][1,2,4]triazepines in ionic liquids. |
| AID1700248 | Antifungal activity against Saccharomyces cerevisiae SH 20 | 2020 | Bioorganic & medicinal chemistry letters, 12-15, Volume: 30, Issue:24 | Synthesis and biological screening of thiosemicarbazones of substituted 3-acetylcoumarins having d-glucose moiety. |
| AID1584746 | Drug metabolism in dog liver microsome S9 fraction assessed as CYP450-mediated metabolism by measuring compound remaining at 5 uM pretreated with NADPH and measured after 15 mins by UPLC-MS/MS analysis | 2018 | Journal of medicinal chemistry, 10-25, Volume: 61, Issue:20 | Discovery of Novel 7-Aryl 7-Deazapurine 3'-Deoxy-ribofuranosyl Nucleosides with Potent Activity against Trypanosoma cruzi. |
| AID1700245 | Antifungal activity against Aspergillus niger ATCC 439 | 2020 | Bioorganic & medicinal chemistry letters, 12-15, Volume: 30, Issue:24 | Synthesis and biological screening of thiosemicarbazones of substituted 3-acetylcoumarins having d-glucose moiety. |
| AID531243 | Antifungal activity against Candida parapsilosis assessed as susceptible isolates after 48 hrs by CLSI method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | In vitro susceptibilities of invasive isolates of Candida species: rapid increase in rates of fluconazole susceptible-dose dependent Candida glabrata isolates. |
| AID1054665 | Antimicrobial activity against Candida glabrata by Alamar blue method | 2013 | European journal of medicinal chemistry, , Volume: 70 | Structure-activity relationship (SAR) and preliminary mode of action studies of 3-substituted benzylthioquinolinium iodide as anti-opportunistic infection agents. |
| AID516264 | Antimicrobial activity against Cryptococcus gattii serotype B isolate NIH179 assessed as concentration required for heteroresistance | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Heteroresistance of Cryptococcus gattii to fluconazole. |
| AID372251 | Fungicidal activity against Candida albicans CHK23 assessed as reduction in cell viability at 4 times MIC of SSK21/CHK21 after 24 hrs | 2007 | Antimicrobial agents and chemotherapy, Oct, Volume: 51, Issue:10 | The Ssk1p response regulator and Chk1p histidine kinase mutants of Candida albicans are hypersensitive to fluconazole and voriconazole. |
| AID1877294 | Inhibition of CYP51 in Candida albicans SC3514 assessed as decrease in ergosterol biosynthesis by measuring lanosterol level at 0.25 ug/ml incubated for 16 hrs by GC-MS analysis relative to total sterols | 2022 | European journal of medicinal chemistry, Jan-05, Volume: 227 | Broadening antifungal spectrum and improving metabolic stablity based on a scaffold strategy: Design, synthesis, and evaluation of novel 4-phenyl-4,5-dihydrooxazole derivatives as potent fungistatic and fungicidal reagents. |
| AID405017 | Antifungal activity against Sporothrix schenckii P25013 isolate from cutaneous-lymphatic sporotrichosis patient after 72 hrs by ATB Fungus 2 method | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | In vitro susceptibility of Sporothrix schenckii to six antifungal agents determined using three different methods. |
| AID655720 | Antifungal activity against Trichoderma viride MTCC 1107 at 40 uM/ml after 48 hrs by paper disc diffusion method | 2012 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 22, Issue:8 | Design, synthesis, synergistic antimicrobial activity and cytotoxicity of 4-aryl substituted 3,4-dihydropyrimidinones of curcumin. |
| AID1877826 | Antifungal activity against Candida albicans CA23 by microdilution method | 2022 | Bioorganic & medicinal chemistry letters, 02-15, Volume: 58 | Synthesis and antifungal evaluation of phenol-derived bis(indolyl)methanes combined with FLC against Candida albicans. |
| AID520619 | Antifungal activity against Candida orthopsilosis by microdilution AFST-EUCAST method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Prevalence and susceptibility profile of Candida metapsilosis and Candida orthopsilosis: results from population-based surveillance of candidemia in Spain. |
| AID757550 | Anticandida activity against Candida glabrata clinical isolate assessed as growth inhibition after 24 hrs by broth microdilution method | 2013 | European journal of medicinal chemistry, Jul, Volume: 65 | Synthesis and cytotoxicity of novel (thiazol-2-yl)hydrazine derivatives as promising anti-Candida agents. |
| AID561437 | Antifungal activity against Candida lusitaniae CL216 by microdilution method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Nonsense and missense mutations in FCY2 and FCY1 genes are responsible for flucytosine resistance and flucytosine-fluconazole cross-resistance in clinical isolates of Candida lusitaniae. |
| AID285865 | Antimicrobial susceptibility of Pichia anomala from nosocomial fungemia patient assessed as percent susceptible isolates at 0.06 ug/ml by EUCAST method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Antifungal drug susceptibility profile of Pichia anomala isolates from patients presenting with nosocomial fungemia. |
| AID581901 | Antifungal activity against Candida glabrata isolated from HSCT recipient 497 with acute or chronic GVHD mouth receiving antifungal drug after 114 days prophylaxis by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Impact of antifungal prophylaxis on colonization and azole susceptibility of Candida species. |
| AID625280 | Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for cholecystitis | 2011 | PLoS computational biology, Dec, Volume: 7, Issue:12 | Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). |
| AID519059 | Antifungal activity against Candida parapsilosis assessed as susceptible isolates after 48 hrs by broth microdilution | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | Antimicrobial activity of omiganan pentahydrochloride against contemporary fungal pathogens responsible for catheter-associated infections. |
| AID1329218 | Antifungal activity against fluconazole-resistant Candida albicans clinical isolate 144 by CLSI broth microdilution method | 2016 | Journal of natural products, 09-23, Volume: 79, Issue:9 | Heptaketides from an Endolichenic Fungus Biatriospora sp. and Their Antifungal Activity. |
| AID1493830 | Antifungal activity against Cryptococcus neoformans 32609 after 24 hrs by spectrophotometric analysis | 2018 | European journal of medicinal chemistry, Jan-01, Volume: 143 | Discovery of simplified sampangine derivatives as novel fungal biofilm inhibitors. |
| AID448161 | Antimicrobial activity against Bacillus cereus 702 Roma at 5 ug after 18 hrs by well diffusion method | 2009 | European journal of medicinal chemistry, Nov, Volume: 44, Issue:11 | Synthesis of some new 1,2,4-triazoles starting from isonicotinic acid hydrazide and evaluation of their antimicrobial activities. |
| AID516261 | Antimicrobial activity against Cryptococcus gattii serotype B isolate NIH535 assessed as concentration required for heteroresistance | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Heteroresistance of Cryptococcus gattii to fluconazole. |
| AID555585 | Antimicrobial activity against Dipodascus capitatus by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Activity profile in vitro of micafungin against Spanish clinical isolates of common and emerging species of yeasts and molds. |
| AID1271242 | Antifungal activity against Candida tropicalis ATCC 750 after 72 hrs by broth microdilution method | 2015 | ACS medicinal chemistry letters, Nov-12, Volume: 6, Issue:11 | Silicon Incorporated Morpholine Antifungals: Design, Synthesis, and Biological Evaluation. |
| AID1549137 | Antifungal activity against azole-resistant Candida albicans 0304103 after 48 hrs by spectrophotometry-based serial microdilution method | 2020 | Journal of medicinal chemistry, 05-28, Volume: 63, Issue:10 | Discovery of Novel Fungal Lanosterol 14α-Demethylase (CYP51)/Histone Deacetylase Dual Inhibitors to Treat Azole-Resistant Candidiasis. |
| AID1601662 | Antifungal activity against planktonic form of Candida albicans ATCC 10231 by broth microdilution method | |||
| AID566877 | Antifungal activity against Candida albicans by microdilution test | 2011 | European journal of medicinal chemistry, Jan, Volume: 46, Issue:1 | Synthesis and antifungal activity of some substituted phenothiazines and related compounds. |
| AID1392816 | Inhibition of Cyp51 in Candida albicans ATCC SC5314 assessed as ergosterol content at 8 ug/ml after 16 hrs by GC-MS analysis (Rvb = 98.7%) | 2018 | Bioorganic & medicinal chemistry, 07-23, Volume: 26, Issue:12 | Design, synthesis and evaluation of benzoheterocycle analogues as potent antifungal agents targeting CYP51. |
| AID1671796 | Antifungal activity against Candida parapsilosis ATCC 22019 assessed as inhibition of fungal growth after 24 hrs by CLSI protocol based two fold serial dilution method | 2019 | European journal of medicinal chemistry, Apr-01, Volume: 167 | Design and synthesis of aminothiazolyl norfloxacin analogues as potential antimicrobial agents and their biological evaluation. |
| AID1726236 | Antifungal activity against Candida tropicalis ATCC 200956 by CLSI standard M27 broth microdilution method | |||
| AID1885987 | Antifungal activity against Candida tropicalis ATCC20026 assessed as fungal growth inhibition incubated for 48 hrs in presence of P163-0892 by broth microdilution method | |||
| AID426131 | Antimicrobial activity against Candida albicans ATCC 60193 at 5 ug after 18 hrs by agar-well diffusion assay | 2009 | European journal of medicinal chemistry, Jul, Volume: 44, Issue:7 | Synthesis of some new 1,3,4-thiadiazol-2-ylmethyl-1,2,4-triazole derivatives and investigation of their antimicrobial activities. |
| AID535690 | Antibacterial activity against Cryptococcus gattii serotype C after 72 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Antifungal susceptibilities among different serotypes of Cryptococcus gattii and Cryptococcus neoformans. |
| AID625286 | Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for hepatitis | 2011 | PLoS computational biology, Dec, Volume: 7, Issue:12 | Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). |
| AID1154851 | Antifungal activity against fluconazole-sensitive Candida albicans SC5314 assessed as change in obtusifoliol composition at 8 ug/ml after 24 hrs by GC-MS analysis relative to control | 2014 | ACS medicinal chemistry letters, May-08, Volume: 5, Issue:5 | Novel carboline derivatives as potent antifungal lead compounds: design, synthesis, and biological evaluation. |
| AID567435 | Antifungal activity against Trichosporon mucoides after 48 hrs by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | In vitro antifungal activities of isavuconazole and comparators against rare yeast pathogens. |
| AID417551 | Antifungal activity against Candida glabrata ATCC 90030 | 2009 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 19, Issue:5 | FR290581, a novel sordarin derivative: synthesis and antifungal activity. |
| AID467905 | Antifungal activity against Sporothrix schenckii after 48 hrs by broth microdilution technique | 2010 | European journal of medicinal chemistry, Feb, Volume: 45, Issue:2 | Imidazole derivatives as possible microbicides with dual protection. |
| AID584587 | Antifungal activity against 111 days cultured Candida glabrata isolated from HSCT recipient with acute or chronic GVHD mouth receiving antifungal therapy for 143 days after 116 days of prophylaxis by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Impact of antifungal prophylaxis on colonization and azole susceptibility of Candida species. |
| AID738390 | Antibacterial activity against Escherichia coli ATCC 8099 after 24 hrs by NCCLS method | 2013 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 23, Issue:7 | Efficient synthesis and antimicrobial activity of some novel S-β-d-glucosides of 5-aryl-1,2,4-triazole-3-thiones derivatives. |
| AID582248 | Antifungal activity against Candida krusei isolated from HSCT recipients with acute or chronic GVHD receiving fluconazole assessed as maximum MIC by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Impact of antifungal prophylaxis on colonization and azole susceptibility of Candida species. |
| AID1369445 | Antifungal activity against Candida albicans SP3903 after 48 hrs by broth microdilution method | 2018 | Journal of medicinal chemistry, 05-10, Volume: 61, Issue:9 | Combating Drug-Resistant Fungi with Novel Imperfectly Amphipathic Palindromic Peptides. |
| AID747352 | Antibacterial activity against Staphylococcus aureus ATCC 25923 by NCCLS method | 2013 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 23, Issue:11 | Synthesis and biological evaluation of a class of quinolone triazoles as potential antimicrobial agents and their interactions with calf thymus DNA. |
| AID1527466 | Antifungal activity against Candida glabrata NCIM-3266 at 18 to 24 hrs by CLSI based alamar blue assay | 2020 | European journal of medicinal chemistry, Jan-01, Volume: 185 | Structure-activity relationships (SAR) of triazine derivatives: Promising antimicrobial agents. |
| AID1609947 | Cytotoxicity against human A549 cells assessed as cell survival at 10 uM/l incubated for 24 hrs by MTT assay relative to control | |||
| AID1886082 | Antifungal activity against Cryptococcus neoformans H99 infected in Wax moth larvae assessed as reduction on fungal burden at 10 mg/kg measured after 9 days by 10 fold serial dilution method | |||
| AID1281675 | Antifungal activity against Candida mycoderma ATCC 9888 after 24 hrs by micro broth dilution method | 2016 | European journal of medicinal chemistry, Mar-23, Volume: 111 | Discovery of membrane active benzimidazole quinolones-based topoisomerase inhibitors as potential DNA-binding antimicrobial agents. |
| AID406860 | Antimicrobial activity against Candida albicans SC5314 dissociated biofilms at cell density of 10'8 cells/ml after 48 hrs by XTT assay | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | Role for cell density in antifungal drug resistance in Candida albicans biofilms. |
| AID1309043 | Antibacterial activity against methicillin-sensitive Staphylococcus aureus isolate SDS15016 after 24 hrs by broth microdilution method | 2016 | Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15 | Synthesis of riccardin D derivatives as potent antimicrobial agents. |
| AID1076264 | Antibacterial activity against Staphylococcus aureus assessed as growth inhibition by microdilution broth susceptibility assay | 2014 | European journal of medicinal chemistry, Mar-21, Volume: 75 | Synthesis, docking and evaluation of antioxidant and antimicrobial activities of novel 1,2,4-triazolo[3,4-b][1,3,4]thiadiazol-6-yl)selenopheno[2,3-d]pyrimidines. |
| AID425143 | Antimicrobial activity against azole-resistant Candida albicans isolate CA10 assessed as growth at 8 ug/ml after 48 hrs by microdilution checkerboard technique relative to control | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | In vitro interactions between tacrolimus and azoles against Candida albicans determined by different methods. |
| AID1877289 | Antifungal activity against FLC-resistant Candida albicans 904 assessed as fungal growth inhibition by NCCLS protocol based method | 2022 | European journal of medicinal chemistry, Jan-05, Volume: 227 | Broadening antifungal spectrum and improving metabolic stablity based on a scaffold strategy: Design, synthesis, and evaluation of novel 4-phenyl-4,5-dihydrooxazole derivatives as potent fungistatic and fungicidal reagents. |
| AID772336 | Antifungal activity against wild type Candida albicans ATCC 60193 after 24 hrs by visually and spectrophotometric analysis | 2013 | ACS medicinal chemistry letters, Sep-12, Volume: 4, Issue:9 | Novel Macrocyclic Amidinoureas: Potent Non-Azole Antifungals Active against Wild-Type and Resistant Candida Species. |
| AID582768 | Antifungal activity against Candida albicans isolate 12 harboring ERG3 W332R mutant gene assessed as ergosterol content in total sterol composition at 0.5 times MIC by GC-MS analysis | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | Identification and characterization of four azole-resistant erg3 mutants of Candida albicans. |
| AID1364332 | Antimicrobial activity against Candida albicans ATCC 90028 by microdilution plate based method | 2017 | Journal of natural products, 04-28, Volume: 80, Issue:4 | Antibacterial Nerol Cinnamates from the Australian Plant Eremophila longifolia. |
| AID405092 | Antimicrobial activity against Rhizopus sp. after 24 hrs | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | In vitro susceptibilities of 217 clinical isolates of zygomycetes to conventional and new antifungal agents. |
| AID419825 | Antifungal activity against Aspergillus niger at 100 ug after 48 hrs by agar disc-diffusion method | 2009 | European journal of medicinal chemistry, Jun, Volume: 44, Issue:6 | Synthesis and antimicrobial evaluation of 1-(benzofuran-2-yl)-4-nitro-3-arylbutan-1-ones and 3-(benzofuran-2-yl)-4,5-dihydro-5-aryl-1-[4-(aryl)-1,3-thiazol-2-yl]-1H-pyrazoles. |
| AID307401 | Antifungal activity against Aspergillus flavus ATCC MYA-1004 by broth microdilution assay | 2007 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 17, Issue:12 | Discovery of novel indazole-linked triazoles as antifungal agents. |
| AID1549162 | Inhibition of HDAC in azole-resistant Candida albicans 0304103 protoplasts using Boc-Lys(Ac)-AMC as substrate preincubated for 12 hrs followed by substrate addition and measured after 4 hrs by fluorimetry | 2020 | Journal of medicinal chemistry, 05-28, Volume: 63, Issue:10 | Discovery of Novel Fungal Lanosterol 14α-Demethylase (CYP51)/Histone Deacetylase Dual Inhibitors to Treat Azole-Resistant Candidiasis. |
| AID1413335 | Antifungal activity against resistant Candida parapsilosis | 2018 | MedChemComm, Jun-01, Volume: 9, Issue:6 | Antifungal amphiphilic kanamycins: new life for an old drug. |
| AID1783773 | Antifungal activity against Cryptococcus neoformans CGMCC2.3161 assessed as inhibition of fungal growth by NCCLS protocol based method | 2021 | European journal of medicinal chemistry, Nov-15, Volume: 224 | Improving the metabolic stability of antifungal compounds based on a scaffold hopping strategy: Design, synthesis, and structure-activity relationship studies of dihydrooxazole derivatives. |
| AID1392829 | Inhibition of Cyp51 in Candida albicans ATCC SC5314 assessed as eburicol content at 8 ug/ml after 16 hrs by GC-MS analysis (Rvb = 0.4%) | 2018 | Bioorganic & medicinal chemistry, 07-23, Volume: 26, Issue:12 | Design, synthesis and evaluation of benzoheterocycle analogues as potent antifungal agents targeting CYP51. |
| AID1905287 | Anti biofilm activity in Candida albicans 904 assessed as downregulation of TEC1 at 32 ug/ml incubated for 24 hrs by RT-PCR analysis | 2022 | Journal of medicinal chemistry, 04-14, Volume: 65, Issue:7 | Species-Selective Targeting of Fungal Hsp90: Design, Synthesis, and Evaluation of Novel 4,5-Diarylisoxazole Derivatives for the Combination Treatment of Azole-Resistant Candidiasis. |
| AID518442 | Antimicrobial activity against Cryptococcus gattii serotype B isolate B4506 assessed as heteroresistant isolates at 4 ug/ml | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Heteroresistance of Cryptococcus gattii to fluconazole. |
| AID520848 | Antifungal activity against Cryptococcus neoformans YC-11 infected in BALB/c mouse assessed as increase in mouse survival at 80 mg/kg, iv qd for 5 days | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | Efficacy of SPK-843, a novel polyene antifungal, in a murine model of systemic cryptococcosis. |
| AID1168353 | Binding affinity to human serum albumin by spectroscopy | 2014 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 24, Issue:21 | Study the interactions between human serum albumin and two antifungal drugs: fluconazole and its analogue DTP. |
| AID1281697 | Antifungal activity against Aspergillus flavus ATCC 204304 after 24 hrs by micro broth dilution method | 2016 | European journal of medicinal chemistry, Mar-23, Volume: 111 | Discovery of membrane active benzimidazole quinolones-based topoisomerase inhibitors as potential DNA-binding antimicrobial agents. |
| AID490331 | Antimicrobial activity against Escherichia coli ATCC 25922 after 24 hrs by microdilution assay | 2010 | European journal of medicinal chemistry, Jul, Volume: 45, Issue:7 | Synthesis and biological evaluation of some thio containing pyrrolo [2,3-d]pyrimidine derivatives for their anti-inflammatory and anti-microbial activities. |
| AID560140 | Antifungal activity against Candida glabrata isolate 21231 at 15 ug after 48 hrs by disk diffusion method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Hypersusceptibility to azole antifungals in a clinical isolate of Candida glabrata with reduced aerobic growth. |
| AID1885972 | Antifungal activity against Cryptococcus neoformans clinical isolate SH68 assessed as fungal growth inhibition incubated for 72 hrs by broth microdilution method | |||
| AID1898158 | Antifungal activity against Microsporum gypseum | |||
| AID1359821 | Antifungal activity against Aspergillus flavus ATCC 16870 measured after 48 hrs by two-dimensional broth microdilution checkboard method | |||
| AID1886037 | Synergistic antifungal activity against Candida tropicalis ATCC20026 assessed as fractional inhibitory concentration index incubated for 48 hrs in presence of P163-0892 by broth microdilution method | |||
| AID294188 | Antifungal activity against Candida albicans ATCC 10231 by macro-broth dilution assay | 2007 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 17, Issue:8 | Synthesis and antimicrobial activity of some novel phenyl and benzimidazole substituted benzyl ethers. |
| AID518164 | Antimicrobial activity against Cryptococcus gattii serotype C isolate H0058-1-78 assessed as concentration required for heteroresistance | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Heteroresistance of Cryptococcus gattii to fluconazole. |
| AID1904385 | Antibiofilm activity against Candida albicans CPCC40061 assessed as inhibition of bacterial metabolism within the biofilm measured after 3 hrs by XTT reduction assay | 2022 | European journal of medicinal chemistry, Apr-05, Volume: 233 | Design, synthesis, and evaluation of novel 3-thiophene derivatives as potent fungistatic and fungicidal reagents based on a conformational restriction strategy. |
| AID1551292 | Antibacterial activity against Staphylococcus aureus KCTC503 assessed as reduction in bacterial cell growth incubated for 24 hrs by ELISA | 2019 | European journal of medicinal chemistry, Jun-15, Volume: 172 | Synthesis and biological evaluation of tryptophan-derived rhodanine derivatives as PTP1B inhibitors and anti-bacterial agents. |
| AID415954 | Antimicrobial activity against Microsporum gypseum by micro-broth dilution method | 2009 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 19, Issue:6 | Design, synthesis, and biological evaluation of novel 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-substituted benzylamino-2-propanols. |
| AID490489 | Antifungal activity against Candida albicans MTCC 227 at 30 ug/ml after 48 hrs by cup-plate method | 2010 | European journal of medicinal chemistry, Jul, Volume: 45, Issue:7 | Synthesis and evaluation of some new benzothiazole derivatives as potential antimicrobial agents. |
| AID1487476 | Antifungal activity against Aspergillus flavus after 24 hrs by well diffusion method | 2017 | Bioorganic & medicinal chemistry letters, 08-15, Volume: 27, Issue:16 | Synthesis, antioxidant, antifungal, molecular docking and ADMET studies of some thiazolyl hydrazones. |
| AID1738745 | Inhibition of CYP51 in azole-resistant Candida albicans ATCC SC531 assessed as Eburicol level at 0.5 ug/ml incubated for 16 hrs by LC-MS analysis relative to control | 2020 | European journal of medicinal chemistry, Jul-15, Volume: 198 | Design, synthesis, and biological evaluation of novel miconazole analogues containing selenium as potent antifungal agents. |
| AID1758004 | Antifungal activity against Cryptococcus neoformans CMGCC2.3161 measured after 72 hrs by broth microdilution assay | 2021 | European journal of medicinal chemistry, Apr-15, Volume: 216 | Lead optimization generates selenium-containing miconazole CYP51 inhibitors with improved pharmacological profile for the treatment of fungal infections. |
| AID1783772 | Antifungal activity against Candida albicans CPCC400523 assessed as inhibition of fungal growth by NCCLS protocol based method | 2021 | European journal of medicinal chemistry, Nov-15, Volume: 224 | Improving the metabolic stability of antifungal compounds based on a scaffold hopping strategy: Design, synthesis, and structure-activity relationship studies of dihydrooxazole derivatives. |
| AID302118 | Antifungal activity against Trichophyton rubrum | 2007 | Journal of medicinal chemistry, Nov-01, Volume: 50, Issue:22 | Synthesis and antifungal activities of novel 2-aminotetralin derivatives. |
| AID1413585 | Inhibition of CYP51 in Candida albicans SC5314 assessed as ergosterol content at 8 ug/ml after 16 hrs by GC/MS analysis (Rvb = 90.3%) | |||
| AID310102 | Antifungal activity against Candida albicans by disc diffusion method | 2007 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 17, Issue:22 | Synthesis and antimicrobial activity of some novel nucleoside analogues of adenosine and 1,3-dideazaadenosine. |
| AID1898171 | Antifungal activity against Candida krusei 463 | |||
| AID477746 | Antimicrobial activity against Aspergillus fumigatus after 24 hrs | 2010 | European journal of medicinal chemistry, Apr, Volume: 45, Issue:4 | An eco-friendly synthesis and antimicrobial activities of dihydro-2H-benzo- and naphtho-1,3-oxazine derivatives. |
| AID527146 | Antifungal activity against Trichophyton mentagrophytes LMGO 09 after 5 days microdilution technique | 2010 | Journal of natural products, Oct-22, Volume: 73, Issue:10 | Search for antifungal compounds from the wood of durable tropical trees. |
| AID595002 | Antifungal activity against Penicillium marneffei after 48 hrs | 2011 | Bioorganic & medicinal chemistry letters, May-15, Volume: 21, Issue:10 | Thermal solvent-free synthesis of novel pyrazolyl chalcones and pyrazolines as potential antimicrobial agents. |
| AID287826 | Antifungal activity against Candida glabrata 20/I after 48 hrs | 2007 | Bioorganic & medicinal chemistry, Apr-15, Volume: 15, Issue:8 | Hybrid molecules of estrone: new compounds with potential antibacterial, antifungal, and antiproliferative activities. |
| AID424662 | Antimicrobial activity against azole-resistant Candida albicans isolate CA10 assessed as growth at 0.5 ug/ml co-treated with 0.031 ug/ml calcineurin signaling inhibitor tacrolimus after 48 hrs by microdilution checkboard technique relative to control | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | In vitro interactions between tacrolimus and azoles against Candida albicans determined by different methods. |
| AID545719 | Antifungal activity against Aspergillus fumigatus after 7 days by serial dilution method | 2010 | European journal of medicinal chemistry, Dec, Volume: 45, Issue:12 | Novel conformationally restricted triazole derivatives with potent antifungal activity. |
| AID1444348 | Antifungal activity against Absidia corymbifera 272 after 24 hrs by broth microdilution method | 2017 | European journal of medicinal chemistry, Apr-21, Volume: 130 | Structure-activity relationship studies on 3,5-dinitrophenyl tetrazoles as antitubercular agents. |
| AID555602 | Antimicrobial activity against Trichosporon spp. by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Activity profile in vitro of micafungin against Spanish clinical isolates of common and emerging species of yeasts and molds. |
| AID1242651 | Antifungal activity against Candida parapsilosis ATCC 22019 after 16 hrs by microtiter broth dilution method | 2015 | ACS medicinal chemistry letters, Jul-09, Volume: 6, Issue:7 | Novel Chalcone-Thiazole Hybrids as Potent Inhibitors of Drug Resistant Staphylococcus aureus. |
| AID521788 | Antifungal activity against 2.44 x 10'8 CFU fluconazole-susceptible Candida glabrata isolate 4293 infected neutropenic CD1 mouse disseminated candidiasis model assessed as reduction in kidney tissue fungal burden at 25 mg/kg/day, ip administered 24 hrs po | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Posaconazole against Candida glabrata isolates with various susceptibilities to fluconazole. |
| AID279124 | Ratio of weight normalized daily dose in candidemia patient to MIC at 48 hrs against Candida glabrata | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Association of fluconazole area under the concentration-time curve/MIC and dose/MIC ratios with mortality in nonneutropenic patients with candidemia. |
| AID1885958 | Antifungal activity against Candida auris CBS 12372 assessed as fungal growth inhibition incubated for 48 hrs by broth microdilution method | |||
| AID320386 | Antimicrobial activity against Benjaminiella poitrasii NCL3 by broth microdilution method | 2008 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 18, Issue:6 | Synthesis and antimicrobial activity of beta-lactam-bile acid conjugates linked via triazole. |
| AID751633 | Antifungal activity against Candida albicans at 300 ppm | 2013 | European journal of medicinal chemistry, Feb, Volume: 60 | Synthesis and antifungal activity of some s-mercaptotriazolobenzothiazolyl amino acid derivatives. |
| AID319757 | Antimicrobial activity against Fonsecaea compacta isolates | 2008 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 18, Issue:11 | Synthesis and SAR studies of biaryloxy-substituted triazoles as antifungal agents. |
| AID518157 | Antimicrobial activity against Cryptococcus gattii serotype C isolate NIH298 assessed as concentration required for heteroresistance | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Heteroresistance of Cryptococcus gattii to fluconazole. |
| AID1758032 | Inhibition of CYP51 in Candida albicans ATCC SC5314 assessed as Obtusifoliol level at 0.125 ug/ml after 16 hrs by GC-MS analysis (Rvb = 0%) | 2021 | European journal of medicinal chemistry, Apr-15, Volume: 216 | Lead optimization generates selenium-containing miconazole CYP51 inhibitors with improved pharmacological profile for the treatment of fungal infections. |
| AID1890305 | Antifungal activity against Mucor circinelloides R7B wild type strain assessed as non-germinated spores at 100 to 150 ug/ml by microscopic analysis | 2022 | Bioorganic & medicinal chemistry letters, 05-01, Volume: 63 | Novel 2-aryl-4-aryloxyquinoline-based fungistatics for Mucor circinelloides. Biological evaluation of activity, QSAR and docking study. |
| AID1556540 | Antifungal activity against Candida tropicalis assessed as reduction in fungal cell viability incubated for 24 hrs by two fold serial dilution method | 2019 | European journal of medicinal chemistry, Oct-01, Volume: 179 | A new exploration towards aminothiazolquinolone oximes as potentially multi-targeting antibacterial agents: Design, synthesis and evaluation acting on microbes, DNA, HSA and topoisomerase IV. |
| AID45513 | Inhibitory effect on Candida albicans YEM15 CDR1CDR2up Strain | 2004 | Journal of medicinal chemistry, Jan-01, Volume: 47, Issue:1 | Folate-synthesizing enzyme system as target for development of inhibitors and inhibitor combinations against Candida albicans-synthesis and biological activity of new 2,4-diaminopyrimidines and 4'-substituted 4-aminodiphenyl sulfones. |
| AID545189 | Antimicrobial activity against Candida albicans isolate R infected in NMRI mouse assessed as decrease in kidney bacterial burden at 50 mg/kg, ip measured on day 4 | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Breakthrough Aspergillus fumigatus and Candida albicans double infection during caspofungin treatment: laboratory characteristics and implication for susceptibility testing. |
| AID1886001 | Antifungal activity against Cryptococcus gattii clinical isolate SCZ20024 assessed as fungal growth inhibition incubated for 72 hrs in presence of P163-0892 by broth microdilution method | |||
| AID372254 | Fungicidal activity against Candida albicans SSK23 assessed as reduction in cell viability at MIC of SSK21/CHK21 after 24 hrs | 2007 | Antimicrobial agents and chemotherapy, Oct, Volume: 51, Issue:10 | The Ssk1p response regulator and Chk1p histidine kinase mutants of Candida albicans are hypersensitive to fluconazole and voriconazole. |
| AID736599 | Antifungal activity against anidulafungin-resistant Candida parapsilosis isolate 22019 assessed as growth inhibition after 24 to 48 hrs by CLSI microbroth dilution method | 2013 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 23, Issue:6 | Synthesis and anti-Candida activity of novel 2-hydrazino-1,3-thiazole derivatives. |
| AID478783 | Antifungal activity against Candida parapsilosis ATCC 22019 after 18 hrs by broth microdilution assay | 2010 | European journal of medicinal chemistry, May, Volume: 45, Issue:5 | Synthesis, spectroscopic and biological studies on the new symmetric Schiff base derived from 2,6-diformyl-4-methylphenol with N-aminopyrimidine. |
| AID569368 | Antifungal activity against Rhizopus species at 1000 ug after 24 hrs by paper disc technique | 2011 | European journal of medicinal chemistry, Feb, Volume: 46, Issue:2 | Efficient and novel one-pot synthesis of antifungal active 1-substituted-8-aryl-3-alkyl/aryl-4H-pyrazolo[4,5-f][1,2,4]triazolo[4,3-b][1,2,4]triazepines using solid support. |
| AID293884 | Antifungal activity against Candida albicans CMAM 0577 after 48 to 72 hrs by broth microdilution method | 2007 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 17, Issue:6 | Synthesis of pseudopeptides based L-tryptophan as a potential antimicrobial agent. |
| AID1430409 | Antifungal activity against Candida glabrata H04 after 24 to 48 hrs by macro-broth dilution method | 2017 | Bioorganic & medicinal chemistry letters, 03-01, Volume: 27, Issue:5 | Methylsulfonyl benzothiazoles (MSBT) derivatives: Search for new potential antimicrobial and anticancer agents. |
| AID547609 | Antifungal activity against Candida glabrata isolate Cg4R with CgPDR1 S391L mutant | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | Microarray and molecular analyses of the azole resistance mechanism in Candida glabrata oropharyngeal isolates. |
| AID1886105 | Cytotoxicity against human HUVEC cells assessed as cell viability at 256 ug/ml incubated for 24 hrs by CCK-8 assay | |||
| AID555574 | Antimicrobial activity against Candida rugosa by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Activity profile in vitro of micafungin against Spanish clinical isolates of common and emerging species of yeasts and molds. |
| AID1246660 | Antifungal activity against Cryptococcus gattii 23/10993 assessed as reduction in cell viability at 26 uM after 6 to 72 hrs by MTT assay | 2015 | European journal of medicinal chemistry, Sep-18, Volume: 102 | Thiazole compounds with activity against Cryptococcus gattii and Cryptococcus neoformans in vitro. |
| AID1435657 | Antifungal activity against Candida tropicalis 156 after 24 hrs by broth microdilution method | 2017 | European journal of medicinal chemistry, Jan-27, Volume: 126 | S-substituted 3,5-dinitrophenyl 1,3,4-oxadiazole-2-thiols and tetrazole-5-thiols as highly efficient antitubercular agents. |
| AID47580 | Evaluation of In vitro antifungal activity against Candida albicans 2.01 by broth macro dilution method | 1995 | Journal of medicinal chemistry, Sep-29, Volume: 38, Issue:20 | Synthesis and antifungal activity of new azole derivatives containing an N-acylmorpholine ring. |
| AID525599 | Antibacterial activity against Fluconazole resistant Candida albicans DSY3083 containing tac1delta/delta genotype by EUCAST standards based broth microdilution method sCandida albicans DSY294 | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Genetic dissection of azole resistance mechanisms in Candida albicans and their validation in a mouse model of disseminated infection. |
| AID293780 | Antimicrobial activity against Candida albicans ATCC 44373 by broth microdilution method | 2007 | Bioorganic & medicinal chemistry, Mar-01, Volume: 15, Issue:5 | Synthesis, antimicrobial activity, and QSAR studies of furan-3-carboxamides. |
| AID1235478 | Inhibition of ergosterol biosynthesis in Candida tropicalis ATCC 750 assessed as ergosterol content after 16 hrs by spectrophotometer analysis | 2015 | Bioorganic & medicinal chemistry, Aug-01, Volume: 23, Issue:15 | Imidazole clubbed 1,3,4-oxadiazole derivatives as potential antifungal agents. |
| AID1348086 | Antimicrobial activity against Staphylococcus epidermidis ATCC 12228 assessed as zone of inhibition at 50 ug per disc after 24 hrs by disc diffusion assay | 2018 | European journal of medicinal chemistry, Jan-01, Volume: 143 | Synthesis of new 1-benzyl tetrahydropyridinylidene ammonium salts and their antimicrobial and anticellular activities. |
| AID1556228 | Inhibition of CYP51 in Candida albicans ATCC SC5314 assessed as eburicol level at 0.5 ug/ml incubated for 16 hrs by GC/MS analysis (Rvb = 0%) | 2019 | European journal of medicinal chemistry, Sep-01, Volume: 177 | Design, synthesis, and structure-activity relationship studies of l-amino alcohol derivatives as broad-spectrum antifungal agents. |
| AID369378 | Antimicrobial activity against Candida haemulonii isolate | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | In vitro susceptibility to posaconazole of 1,903 yeast isolates recovered in France from 2003 to 2006 and tested by the method of the European committee on antimicrobial susceptibility testing. |
| AID581903 | Antifungal activity against Candida glabrata isolated from HSCT recipient 807 with acute or chronic GVHD mouth receiving antifungal drug after 114 days prophylaxis by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Impact of antifungal prophylaxis on colonization and azole susceptibility of Candida species. |
| AID1329215 | Antifungal activity against fluconazole-resistant Candida albicans clinical isolate 24D by CLSI broth microdilution method | 2016 | Journal of natural products, 09-23, Volume: 79, Issue:9 | Heptaketides from an Endolichenic Fungus Biatriospora sp. and Their Antifungal Activity. |
| AID674386 | Antifungal activity against Chrysosporium keratinophilum MTCC 3017 at 1 mg/ml after 72 hrs by well plate method | 2012 | Bioorganic & medicinal chemistry letters, Jul-15, Volume: 22, Issue:14 | Synthesis of benzofuran based 1,3,5-substituted pyrazole derivatives: as a new class of potent antioxidants and antimicrobials--a novel accost to amend biocompatibility. |
| AID47587 | Evaluation of In vivo antifungal activity against Candida albicans 60 by broth macro dilution method | 1995 | Journal of medicinal chemistry, Sep-29, Volume: 38, Issue:20 | Synthesis and antifungal activity of new azole derivatives containing an N-acylmorpholine ring. |
| AID518421 | Antimicrobial activity against Cryptococcus gattii serotype C isolate H0058-1-78 assessed as heteroresistant isolates at 2 ug/ml | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Heteroresistance of Cryptococcus gattii to fluconazole. |
| AID619413 | Antifungal activity against Penicillium sp. assessed as inhibition of mycelial growth at 4 mg/ml after 7 days | 2011 | European journal of medicinal chemistry, Oct, Volume: 46, Issue:10 | Synthesis and biological evaluation of dihydroindeno and indeno [1,2-e] [1,2,4]triazolo [3,4-b] [1,3,4]thiadiazines as antimicrobial agents. |
| AID1886041 | Synergistic antifungal activity against Cryptococcus neoformans clinical isolate HN2-40 assessed as fractional inhibitory concentration index incubated for 72 hrs in presence of P163-0892 by broth microdilution method | |||
| AID352119 | Antifungal activity against Aspergillus fumigatus after 26 hrs by serial plate dilution method | 2009 | European journal of medicinal chemistry, Mar, Volume: 44, Issue:3 | Antimicrobial studies of some novel quinazolinones fused with [1,2,4]-triazole, [1,2,4]-triazine and [1,2,4,5]-tetrazine rings. |
| AID1551802 | Antibacterial activity against Escherichia coli ATCC 25922 after 24 hrs by microdilution method | 2019 | European journal of medicinal chemistry, Jul-01, Volume: 173 | Antibacterial activity study of 1,2,4-triazole derivatives. |
| AID1329224 | Inhibition of CDR1/CDR2 in Candida albicans clinical isolate 144 assessed as potentiation of fluconazole-induced antifungal activity by measuring fluconazole MIC80 up to 8 ug/ml after 24 hrs by XTT based broth microdilution assay (Rvb = >128 ug/ml) | 2016 | Journal of natural products, 09-23, Volume: 79, Issue:9 | Heptaketides from an Endolichenic Fungus Biatriospora sp. and Their Antifungal Activity. |
| AID1601664 | Antibiofilm activity against Candida albicans PMC 1042 assessed as inhibition of biofilm formation by XTT reduction assay | |||
| AID1764054 | Antifungal activity against Candida albicans CAAL93 assessed as reduction in fungal growth | 2021 | Bioorganic & medicinal chemistry letters, 09-01, Volume: 47 | Anti-protozoal and anti-fungal evaluation of 3,5-disubstituted 1,2-dioxolanes. |
| AID486716 | Antifungal activity against Saccharomyces cerevisiae DSMZ 1333 after 24 hrs by macrodilution method | 2010 | European journal of medicinal chemistry, Jun, Volume: 45, Issue:6 | Design, synthesis and determination of antifungal activity of 5(6)-substituted benzotriazoles. |
| AID518668 | Antimicrobial activity against Cryptococcus gattii serotype B isolate RB14 assessed as heteroresistant isolates at 8 ug/ml | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Heteroresistance of Cryptococcus gattii to fluconazole. |
| AID257547 | Antifungal activity against Trichophyton mentagrophytes | 2005 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 15, Issue:23 | Synthesis and biological evaluation of novel (L)-alpha-amino acid methyl ester, heteroalkyl, and aryl substituted 1,4-naphthoquinone derivatives as antifungal and antibacterial agents. |
| AID494611 | Antifungal activity against Candida albicans E81022 after 2 days by broth-microdilution method | 2010 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 20, Issue:15 | Synthesis and evaluation of novel antifungal agents-quinoline and pyridine amide derivatives. |
| AID608676 | Antifungal activity against Microsporum gypseum at 1000 ug/ml after 72 hrs by agar diffusion method | 2011 | European journal of medicinal chemistry, Aug, Volume: 46, Issue:8 | Synthesis, characterization and antimicrobial studies of some new pyrazole incorporated imidazole derivatives. |
| AID1861422 | Antifungal activity against clinical strain Candida albicans CA187 assessed as inhibition of fungal growth by microdilution method | 2022 | Bioorganic & medicinal chemistry letters, 09-01, Volume: 71 | Discovery of novel indole and indoline derivatives against Candida albicans as potent antifungal agents. |
| AID1885996 | Antifungal activity against Cryptococcus neoformans clinical isolate BJ3 assessed as fungal growth inhibition incubated for 72 hrs in presence of P163-0892 by broth microdilution method | |||
| AID1890302 | Antifungal activity against Mucor circinelloides M5 strain assessed as non-germinated spores and undifferentiated hyphae at 50 ug/ml by microscopic analysis | 2022 | Bioorganic & medicinal chemistry letters, 05-01, Volume: 63 | Novel 2-aryl-4-aryloxyquinoline-based fungistatics for Mucor circinelloides. Biological evaluation of activity, QSAR and docking study. |
| AID293876 | Antifungal activity against Candida albicans CMAH 0501 after 48 to 72 hrs by broth microdilution method | 2007 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 17, Issue:6 | Synthesis of pseudopeptides based L-tryptophan as a potential antimicrobial agent. |
| AID340960 | Antifungal activity against Candida rugosa isolates from feeding stuff by NCCLS M27-A2 method | 2007 | Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8 | Cross-resistance to medical and agricultural azole drugs in yeasts from the oropharynx of human immunodeficiency virus patients and from environmental Bavarian vine grapes. |
| AID1246773 | Antifungal activity against Cryptococcus gattii 23/10993 after 48 to 72 hrs by broth microdilution method | 2015 | European journal of medicinal chemistry, Sep-18, Volume: 102 | Thiazole compounds with activity against Cryptococcus gattii and Cryptococcus neoformans in vitro. |
| AID55176 | Minimum inhibitory concentration of compound for antifungal activity against Cryptococcus neoformans | 2000 | Bioorganic & medicinal chemistry letters, Oct-02, Volume: 10, Issue:19 | Novel antifungals based on 4-substituted imidazole: a combinatorial chemistry approach to lead discovery and optimization. |
| AID1300880 | Antifungal activity against Candida tropicalis clinical isolate after 24 hrs by broth microdilution method | 2016 | European journal of medicinal chemistry, Jul-19, Volume: 117 | Novel 1,3-thiazolidin-4-one derivatives as promising anti-Candida agents endowed with anti-oxidant and chelating properties. |
| AID1689218 | Antifungal activity against Candida parapsilosis CAB 502638 assessed as reduction in fungal growth incubated for 24 hrs by CLSI based broth microdilution method | 2020 | European journal of medicinal chemistry, Mar-01, Volume: 189 | Oxadiazolylthiazoles as novel and selective antifungal agents. |
| AID1279032 | Antifungal activity against Absidia corymbifera 272 after 48 hrs by microbroth dilution method | 2016 | Bioorganic & medicinal chemistry, Mar-15, Volume: 24, Issue:6 | Salicylanilide N-monosubstituted carbamates: Synthesis and in vitro antimicrobial activity. |
| AID1157290 | Antifungal activity against Candida albicans Y0109 assessed as growth inhibition by automatic microplate reader analysis | 2014 | Journal of natural products, May-23, Volume: 77, Issue:5 | Polyhydroxy cyclohexanols from a Dendrodochium sp. fungus associated with the sea cucumber Holothuria nobilis Selenka. |
| AID1329214 | Antifungal activity against Candida albicans SC5314 by CLSI broth microdilution method | 2016 | Journal of natural products, 09-23, Volume: 79, Issue:9 | Heptaketides from an Endolichenic Fungus Biatriospora sp. and Their Antifungal Activity. |
| AID37585 | Antifungal activity against Aspergillus niger IMI17454 strain. | 2004 | Journal of medicinal chemistry, Apr-08, Volume: 47, Issue:8 | Distamycin analogues with enhanced lipophilicity: synthesis and antimicrobial activity. |
| AID477743 | Antimicrobial activity against Cryptococcus neoformans after 24 hrs | 2010 | European journal of medicinal chemistry, Apr, Volume: 45, Issue:4 | An eco-friendly synthesis and antimicrobial activities of dihydro-2H-benzo- and naphtho-1,3-oxazine derivatives. |
| AID1254328 | Antifungal activity against Trichophyton mentagrophytes 445 after 24 hrs by microdilution broth method | 2015 | Bioorganic & medicinal chemistry, Nov-15, Volume: 23, Issue:22 | Novel derivatives of nitro-substituted salicylic acids: Synthesis, antimicrobial activity and cytotoxicity. |
| AID554717 | Antimicrobial activity against Saccharomyces cerevisiae isolate ADdelta overexpressing Abc1p after 48 hrs by liquid microdilution assay | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Abc1p is a multidrug efflux transporter that tips the balance in favor of innate azole resistance in Candida krusei. |
| AID625775 | Hydrophobicity, Log P of the compound | 2011 | European journal of medicinal chemistry, Nov, Volume: 46, Issue:11 | Design and synthesis of novel triazole antifungal derivatives by structure-based bioisosterism. |
| AID1624178 | Antifungal activity against Candida albicans NR-29440 after 24 hrs by microbroth dilution method | 2019 | Bioorganic & medicinal chemistry letters, 03-01, Volume: 29, Issue:5 | Benzimidazole tethered pyrrolo[3,4-b]quinoline with broad-spectrum activity against fungal pathogens. |
| AID436745 | Antifungal activity against Candida parapsilosis after 24 hrs by serial dilution method | 2009 | European journal of medicinal chemistry, Oct, Volume: 44, Issue:10 | New azoles with potent antifungal activity: design, synthesis and molecular docking. |
| AID1864908 | Inhibition of CYP51 in Candida albicans SC5314 using Eburicol as substrate preincubated for 20 mins followed by substrate addition and measured after 4 mins by HPLC analysis | |||
| AID1592229 | Inhibition of SE/CYP51 in Candida albicans ATCC SC5314 assessed as effect on sterol composition by measuring Eburicol level at 16 ug/ml incubated for 90 mins by HPLC analysis (Rvb = 8.3%) | 2019 | Bioorganic & medicinal chemistry, 06-15, Volume: 27, Issue:12 | Design, synthesis and biological evaluation of amide-pyridine derivatives as novel dual-target (SE, CYP51) antifungal inhibitors. |
| AID1419502 | Antifungal activity against Candida parapsilosis ATCC 22019 incubated for 48 hrs by modified CLSI M27-A3 protocol based method | 2017 | European journal of medicinal chemistry, Jun-16, Volume: 133 | Novel alkylated azoles as potent antifungals. |
| AID405192 | Antimicrobial activity against Blastoschizomyces capitatus IHEM 5666 isolate infected OF1 mouse blastoschizomycosis model assessed as mean survival time at 80 mg/kg/day, po for 6 days administered 1 hr before microbial challenge | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | Combined therapies in a murine model of blastoschizomycosis. |
| AID766649 | Antifungal activity against Candida albicans MTCC 1637 after 24 hrs by well diffusion method | 2013 | European journal of medicinal chemistry, Sep, Volume: 67 | Total synthesis and biological evaluation of clavaminol-G and its analogs. |
| AID568477 | Antifungal activity against Candida tropicalis KCCM 50662 after 1 day by twofold broth dilution method | 2011 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 21, Issue:3 | Synthesis and antifungal activity of furo[2,3-f]quinolin-5-ols. |
| AID1330190 | Antibacterial activity against Escherichia coli 1356 measured after 24 hrs by two-fold serial dilution method | 2016 | Bioorganic & medicinal chemistry letters, 12-15, Volume: 26, Issue:24 | Synthesis and biological evaluation of chalcone derivatives containing aminoguanidine or acylhydrazone moieties. |
| AID269976 | Antifungal activity against Candida albicans CBS 562 | 2006 | Journal of medicinal chemistry, Aug-10, Volume: 49, Issue:16 | Synthesis and antifungal activity of a novel series of alkyldimethylamine cyanoboranes and their derivatives. |
| AID1864909 | Antifungal actvity against Candida albicans ATCC SC5314 infected in mouse assessed as reduction in infection at 10 ug per 20 g, ip administered on day 2, 4, 6, 8, 10 and 12 and measured on day 14 | |||
| AID1890272 | Antifungal activity against Microsporum canis clinical isolate 2 assessed as reduction in fungal growth by broth dilution method | 2022 | Bioorganic & medicinal chemistry letters, 05-01, Volume: 63 | Novel 2-aryl-4-aryloxyquinoline-based fungistatics for Mucor circinelloides. Biological evaluation of activity, QSAR and docking study. |
| AID1595084 | Antifungal activity against Candida tropicalis assessed as reduction in fungal cell growth incubated for 24 hrs by broth microdilution method | 2019 | European journal of medicinal chemistry, May-15, Volume: 170 | Tetrazole hybrids and their antifungal activities. |
| AID1369450 | Antifungal activity against fluconazole-resistant Candida albicans 56214 after 48 hrs by broth microdilution method | 2018 | Journal of medicinal chemistry, 05-10, Volume: 61, Issue:9 | Combating Drug-Resistant Fungi with Novel Imperfectly Amphipathic Palindromic Peptides. |
| AID1493839 | Antifungal activity against fluconazole-resistant Candida albicans clinical isolate 103 after 24 hrs by spectrophotometric analysis | 2018 | European journal of medicinal chemistry, Jan-01, Volume: 143 | Discovery of simplified sampangine derivatives as novel fungal biofilm inhibitors. |
| AID509284 | Permeability across BBMEC cocultured with rat C6 cell BBB model after 24 hrs in presence of 0.01 ug/ml tacrolimus-506 | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Effects of immunomodulatory and organism-associated molecules on the permeability of an in vitro blood-brain barrier model to amphotericin B and fluconazole. |
| AID518150 | Antimicrobial activity against Cryptococcus gattii serotype B isolate B5788 assessed as concentration required for heteroresistance | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Heteroresistance of Cryptococcus gattii to fluconazole. |
| AID434363 | Antifungal activity against sTrichophyton mentagrophytes after 96 hrs by broth microdilution method | 2009 | European journal of medicinal chemistry, Aug, Volume: 44, Issue:8 | Design, synthesis and biological evaluation of novel nitrogen and sulfur containing hetero-1,4-naphthoquinones as potent antifungal and antibacterial agents. |
| AID712897 | Antifungal activity against Aspergillus fumigatus after 72 hrs by agar disk diffusion method | 2012 | European journal of medicinal chemistry, Aug, Volume: 54 | Synthesis and evaluation of antimicrobial activity of 4H-pyrimido[2,1-b]benzothiazole, pyrazole and benzylidene derivatives of curcumin. |
| AID1054567 | Antifungal activity against Sporothrix schenckii after 48 hrs by broth microdilution technique | 2013 | European journal of medicinal chemistry, , Volume: 70 | Azole-carbodithioate hybrids as vaginal anti-Candida contraceptive agents: design, synthesis and docking studies. |
| AID1728464 | Antifungal activity against fluconazole-resistant Candida albicans 632 assessed as inhibition of microbial growth by NCCLS protocol based method | 2021 | European journal of medicinal chemistry, Jan-15, Volume: 210 | Novel naphthylamide derivatives as dual-target antifungal inhibitors: Design, synthesis and biological evaluation. |
| AID1487497 | Antifungal activity against Candida albicans assessed as zone of inhibition at 50 ug/ml measured after 24 hrs by well diffusion method | 2017 | Bioorganic & medicinal chemistry letters, 08-15, Volume: 27, Issue:16 | Synthesis, antioxidant, antifungal, molecular docking and ADMET studies of some thiazolyl hydrazones. |
| AID1348788 | Antifungal activity against Candida albicans ATCC 14053 after 48 hrs by broth microdilution method | 2018 | European journal of medicinal chemistry, Jan-01, Volume: 143 | Substituted carbamothioic amine-1-carbothioic thioanhydrides as novel trichomonicidal fungicides: Design, synthesis, and biology. |
| AID1609935 | Inhibition of Candida albicans CYP51 assessed as ergosterol level at 0.25 ug/ml incubated for 18 hrs by GC/MS analysis (Rvb = 100%) | |||
| AID1232308 | Distribution coefficient, log D of the compound | 2015 | Journal of medicinal chemistry, Aug-13, Volume: 58, Issue:15 | Volume of Distribution in Drug Design. |
| AID734701 | Antifungal activity against Candida albicans MTCC 3017 after 48 hrs by agar dilution method | 2013 | European journal of medicinal chemistry, Apr, Volume: 62 | Synthesis, biological evaluation of new oxazolidino-sulfonamides as potential antimicrobial agents. |
| AID1557090 | Cytotoxicity against human HepG2 cells assessed as reduction in cell viability at 5 to 50 uM incubated for 24 hrs by XTT assay | 2019 | European journal of medicinal chemistry, Oct-01, Volume: 179 | Antifungal activity, mode of action variability, and subcellular distribution of coumarin-based antifungal azoles. |
| AID1738737 | Inhibition of CYP51 in azole-resistant Candida albicans ATCC SC531 assessed as Obtusifoliol level at 8 ug/ml incubated for 16 hrs by LC-MS analysis relative to control | 2020 | European journal of medicinal chemistry, Jul-15, Volume: 198 | Design, synthesis, and biological evaluation of novel miconazole analogues containing selenium as potent antifungal agents. |
| AID405213 | Antimicrobial activity against Blastoschizomyces capitatus IHEM 5666 isolate infected OF1 mouse blastoschizomycosis model assessed as spleen microbial count per gram of tissue at 80 mg/kg/day, po for 6 days administered 1 hr before microbial challenge | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | Combined therapies in a murine model of blastoschizomycosis. |
| AID750768 | Antifungal activity against Aspergillus flavus MTCC 1021 assessed as zone of inhibition at 80 uM after 48 hrs by disc diffusion method | 2013 | European journal of medicinal chemistry, Jun, Volume: 64 | Biological activity, design, synthesis and structure activity relationship of some novel derivatives of curcumin containing sulfonamides. |
| AID361985 | Lipophilicity, log D of compound at pH 7.4 by microfluidic liquid-liquid extraction method | 2008 | Journal of medicinal chemistry, Aug-28, Volume: 51, Issue:16 | Determination of log D via automated microfluidic liquid-liquid extraction. |
| AID1877433 | Antifungal activity against Candida tropicalis | 2022 | Bioorganic & medicinal chemistry letters, 01-01, Volume: 55 | New bis- and tetrakis-1,2,3-triazole derivatives: Synthesis, DNA cleavage, molecular docking, antimicrobial, antioxidant activity and acid dissociation constants. |
| AID405214 | Antimicrobial activity against Blastoschizomyces capitatus IHEM 5666 isolate infected OF1 mouse blastoschizomycosis model assessed as kidney microbial count per gram of tissue at 80 mg/kg/day, po for 6 days administered 1 hr before microbial challenge | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | Combined therapies in a murine model of blastoschizomycosis. |
| AID245420 | Minimum inhibitory concentration against Candida albicans A261 evaluated by in vitro agar diffusion and micro-broth dilution assay | 2005 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 15, Issue:15 | Synthesis of some diguanidino 1-methyl-2,5-diaryl-1H-pyrroles as antifungal agents. |
| AID416942 | Antifungal activity against Candida albicans by broth microdilution test | 2009 | Bioorganic & medicinal chemistry, Mar-15, Volume: 17, Issue:6 | Exploration of click reaction for the synthesis of modified nucleosides as chitin synthase inhibitors. |
| AID1180302 | Fungicidal activity against Aspergillus flavus NCIM-539 after 48 to 72 hrs by two fold serial macrodilution technique | 2014 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 24, Issue:15 | One pot three components microwave assisted and conventional synthesis of new 3-(4-chloro-2-hydroxyphenyl)-2-(substituted) thiazolidin-4-one as antimicrobial agents. |
| AID1864931 | Antifungal activity against Candida albicans ATCC SC5314 assessed as induction of ROS production by measuring fluorescence intensity incubated for 12 hrs by KGT010-1 staining based fluorescence microscopy | |||
| AID46929 | Antifungal activity against Candida albicans at an intraperitoneal dose of 20 mg/kg twice a day for 6 days in mice in experiment 2 | 2004 | Bioorganic & medicinal chemistry letters, Mar-08, Volume: 14, Issue:5 | Approaches towards the stabilization of hemiaminal function at ornithine unit of mulundocandin. |
| AID1592220 | Antifungal activity against fluconazole-resistant Candida albicans 103 assessed as inhibition of microbial growth by NCCLS protocol based method | 2019 | Bioorganic & medicinal chemistry, 06-15, Volume: 27, Issue:12 | Design, synthesis and biological evaluation of amide-pyridine derivatives as novel dual-target (SE, CYP51) antifungal inhibitors. |
| AID285871 | Antimicrobial susceptibility of Pichia anomala from nosocomial fungemia patient assessed as percent susceptible isolates at 4 ug/ml by EUCAST method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Antifungal drug susceptibility profile of Pichia anomala isolates from patients presenting with nosocomial fungemia. |
| AID1265815 | Antifungal activity against azole-resistant Candida albicans ATCC 64124 after 48 hrs by microbroth dilution method | 2015 | Journal of medicinal chemistry, Dec-10, Volume: 58, Issue:23 | Synthesis and Bioactivities of Kanamycin B-Derived Cationic Amphiphiles. |
| AID625673 | Antifungal activity against Candida albicans after 48 hrs by agar disk diffusion assay | 2011 | European journal of medicinal chemistry, Nov, Volume: 46, Issue:11 | L-Proline anchored multicomponent synthesis of novel pyrido[2,3-a]carbazoles; investigation of in vitro antimicrobial, antioxidant, cytotoxicity and structure activity relationship studies. |
| AID425127 | Antimicrobial activity against azole-resistant Candida albicans isolate CA10 assessed as growth at 4 ug/ml cotreated with 0.002 ug/ml calcineurin signaling inhibitor tacrolimus after 48 hrs by microdilution checkerboard technique relative to control | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | In vitro interactions between tacrolimus and azoles against Candida albicans determined by different methods. |
| AID518885 | Antimicrobial activity against Cryptococcus gattii serotype B isolate RAM002 assessed as heteroresistant isolates at 32 ug/ml | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Heteroresistance of Cryptococcus gattii to fluconazole. |
| AID1330188 | Antibacterial activity against Streptococcus mutans 3065 measured after 24 hrs by two-fold serial dilution method | 2016 | Bioorganic & medicinal chemistry letters, 12-15, Volume: 26, Issue:24 | Synthesis and biological evaluation of chalcone derivatives containing aminoguanidine or acylhydrazone moieties. |
| AID49647 | In vitro antifungal activity against Candida albicans (CY1002) in 80% calf serum | 2003 | Bioorganic & medicinal chemistry letters, Jan-06, Volume: 13, Issue:1 | Design and synthesis of novel benzofurans as a new class of antifungal agents targeting fungal N-myristoyltransferase. Part 3. |
| AID1199855 | Inhibition of recombinant histone acetyltransferase p300 (unknown origin) using dH3-H4 tetramer and [3H]-acetyl-CoA assessed as acetate incorporation after 30 mins by liquid scintillation counting | 2015 | Journal of medicinal chemistry, Mar-12, Volume: 58, Issue:5 | PAINS in the assay: chemical mechanisms of assay interference and promiscuous enzymatic inhibition observed during a sulfhydryl-scavenging HTS. |
| AID518165 | Antimicrobial activity against Cryptococcus gattii serotype C isolate H0058-1-2023 assessed as concentration required for heteroresistance | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Heteroresistance of Cryptococcus gattii to fluconazole. |
| AID1265820 | Antifungal activity against azole-resistant Candida albicans MYA-1003 after 48 hrs by microbroth dilution method | 2015 | Journal of medicinal chemistry, Dec-10, Volume: 58, Issue:23 | Synthesis and Bioactivities of Kanamycin B-Derived Cationic Amphiphiles. |
| AID406864 | Antimicrobial activity against Candida albicans GDH2346 dissociated biofilms at cell density of 10'3 cells/ml after 48 hrs by XTT assay | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | Role for cell density in antifungal drug resistance in Candida albicans biofilms. |
| AID417554 | Antifungal activity against Aspergillus fumigatus ATCC 204305 | 2009 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 19, Issue:5 | FR290581, a novel sordarin derivative: synthesis and antifungal activity. |
| AID1495962 | Fungicidal activity against Candida albicans measured after 72 hrs | 2018 | Bioorganic & medicinal chemistry, 07-23, Volume: 26, Issue:12 | Efficiency of newly prepared thiazole derivatives against some cutaneous fungi. |
| AID424654 | Antimicrobial activity against azole-resistant Candida albicans isolate CA10 assessed as growth at 4 ug/ml cotreated with 0.063 ug/ml calcineurin signaling inhibitor Tacrolimus after 48 hrs by microdilution checkboard technique relative to control | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | In vitro interactions between tacrolimus and azoles against Candida albicans determined by different methods. |
| AID518181 | Antimicrobial activity against Cryptococcus gattii serotype B isolate NIH367 assessed as heteroresistant isolates at 2 ug/ml | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Heteroresistance of Cryptococcus gattii to fluconazole. |
| AID1193900 | Antifungal activity against Penicillium notatum assessed as zone of inhibition at 5 mg/ml after 24 hrs by agar well diffusion method | 2015 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 25, Issue:7 | Rapid 'one-pot' synthesis of a novel benzimidazole-5-carboxylate and its hydrazone derivatives as potential anti-inflammatory and antimicrobial agents. |
| AID1168332 | Binding affinity to human serum albumin at 310 K by Scatchard method | 2014 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 24, Issue:21 | Study the interactions between human serum albumin and two antifungal drugs: fluconazole and its analogue DTP. |
| AID1602385 | Antifungal activity against Cryptococcus neoformans H99 assessed as damaged cell membranes at 4 ug/ml after 24 hrs by TEM analysis | 2019 | Journal of medicinal chemistry, 03-14, Volume: 62, Issue:5 | Discovery of Carboline Derivatives as Potent Antifungal Agents for the Treatment of Cryptococcal Meningitis. |
| AID1059349 | Fungicidal activity against Candida tropicalis clinical isolate by micro dilution method | 2013 | European journal of medicinal chemistry, , Volume: 70 | Designing and synthesis of novel antimicrobial heterocyclic analogs of fatty acids. |
| AID1886039 | Synergistic antifungal activity against Cryptococcus neoformans clinical isolate HN1 assessed as fractional inhibitory concentration index incubated for 72 hrs in presence of P163-0892 by broth microdilution method | |||
| AID584379 | Ratio of CDR2 gene expression in Candida glabrata isolated from patient 807 receiving antifungal drug to CDR2 gene expression in Candida glabrata isolated from patient 807 by RT-PCR analysis | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Impact of antifungal prophylaxis on colonization and azole susceptibility of Candida species. |
| AID293878 | Antifungal activity against Candida albicans CMAH 0507 after 48 to 72 hrs by broth microdilution method | 2007 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 17, Issue:6 | Synthesis of pseudopeptides based L-tryptophan as a potential antimicrobial agent. |
| AID486712 | Antifungal activity against Candida albicans ATCC 90028 after 24 hrs by macrodilution method | 2010 | European journal of medicinal chemistry, Jun, Volume: 45, Issue:6 | Design, synthesis and determination of antifungal activity of 5(6)-substituted benzotriazoles. |
| AID545280 | Antifungal activity against Trichophyton mentagrophytes after 24 hrs by broth microdilution method | 2010 | European journal of medicinal chemistry, Dec, Volume: 45, Issue:12 | New amino acid esters of salicylanilides active against MDR-TB and other microbes. |
| AID1494184 | Antifungal activity against Aspergillus flavus ATCC MYA-3631 measured after 48 hrs by CLSI M38-A2 protocol based method | 2018 | Bioorganic & medicinal chemistry, 02-01, Volume: 26, Issue:3 | Novel fluconazole derivatives with promising antifungal activity. |
| AID294189 | Antifungal activity against Candida krusei ATCC 6258 by macro-broth dilution assay | 2007 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 17, Issue:8 | Synthesis and antimicrobial activity of some novel phenyl and benzimidazole substituted benzyl ethers. |
| AID262550 | Antifungal activity against Aspergillus fumigatus | 2006 | Journal of medicinal chemistry, Apr-20, Volume: 49, Issue:8 | Structure-based optimization of azole antifungal agents by CoMFA, CoMSIA, and molecular docking. |
| AID588209 | Literature-mined public compounds from Greene et al multi-species hepatotoxicity modelling dataset | 2010 | Chemical research in toxicology, Jul-19, Volume: 23, Issue:7 | Developing structure-activity relationships for the prediction of hepatotoxicity. |
| AID1300883 | Antifungal activity against Candida sake clinical isolate after 24 hrs by broth microdilution method | 2016 | European journal of medicinal chemistry, Jul-19, Volume: 117 | Novel 1,3-thiazolidin-4-one derivatives as promising anti-Candida agents endowed with anti-oxidant and chelating properties. |
| AID1698045 | Antifungal activity against Aspergillus niger assessed as inhibition of fungal growth incubated for 24 hrs by agar well diffusion method | 2020 | Bioorganic & medicinal chemistry letters, 11-15, Volume: 30, Issue:22 | Design and synthesis of new indanol-1,2,3-triazole derivatives as potent antitubercular and antimicrobial agents. |
| AID118898 | In vivo antifungal activity against murine candidosis model after peroral administration with 1 mg/kg for 5 days.(percent protection for 100% mortality with untreated group) | 1998 | Journal of medicinal chemistry, May-21, Volume: 41, Issue:11 | New azole antifungals. 2. Synthesis and antifungal activity of heterocyclecarboxamide derivatives of 3-amino-2-aryl-1-azolyl-2-butanol. |
| AID522316 | Fungistatic activity against wild type Candida glabrata TG11 assessed as reduction in bacterial cell viability by time kill study | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Roles of calcineurin and Crz1 in antifungal susceptibility and virulence of Candida glabrata. |
| AID550090 | Antifungal activity against Candida albicans NCIM-3557 after 48 hrs by broth microdilution assay | 2011 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 21, Issue:1 | Design and synthesis of 3-(azol-1-yl)phenylpropanes as microbicidal spermicides for prophylactic contraception. |
| AID518407 | Antimicrobial activity against Cryptococcus gattii serotype B isolate B4506 assessed as heteroresistant isolates at 2 ug/ml | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Heteroresistance of Cryptococcus gattii to fluconazole. |
| AID532527 | Antifungal activity against Saccharomyces cerevisiae BY4741 harboring human CYP51 assessed as growth rate at 16 ug/ml (Rvb = 0.157%) | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | Differential azole antifungal efficacies contrasted using a Saccharomyces cerevisiae strain humanized for sterol 14 alpha-demethylase at the homologous locus. |
| AID521980 | Antibacterial activity against Fluconazole resistant Candida albicans DSY3083 containing tac1delta/delta genotype containing CIp10 to restore URA3 function infected in BALB/c mouse assessed as weight change administered intraperitoneally 1 hr post bacteri | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Genetic dissection of azole resistance mechanisms in Candida albicans and their validation in a mouse model of disseminated infection. |
| AID1157186 | Antifungal activity against Candida albicans PMC 1042R after 48 hrs by CLSI broth microdilution method | 2014 | European journal of medicinal chemistry, Aug-18, Volume: 83 | Synthesis, biological evaluation and structure-activity correlation study of a series of imidazol-based compounds as Candida albicans inhibitors. |
| AID1201633 | Antimicrobial activity against Aspergillus flavus ATCC 9643 assessed as diameter of zone of inhibition at 20 microg/disc after 24 hrs by agar well diffusion method | 2015 | European journal of medicinal chemistry, May-05, Volume: 95 | Synthesis, biological evaluation and molecular docking of some substituted pyrazolines and isoxazolines as potential antimicrobial agents. |
| AID521504 | Antifungal activity against Cryptococcus neoformans TIMM 0354 after 72 hrs by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | In vitro and in vivo antifungal activities of T-2307, a novel arylamidine. |
| AID546070 | Antifungal activity against Candida parapsilosis isolated from candidemia patient by AFST-EUCAST microdilution method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | A 10-year survey of antifungal susceptibility of candidemia isolates from intensive care unit patients in Greece. |
| AID1634363 | Antifungal activity against fluconazole-resistant Candida albicans 103 assessed as inhibition of visible microbe growth by broth microdilution method | 2019 | Bioorganic & medicinal chemistry letters, 09-01, Volume: 29, Issue:17 | Design, synthesis and evaluation of biphenyl imidazole analogues as potent antifungal agents. |
| AID262558 | Antifungal activity against Epidermophyton floccosum | 2006 | Journal of medicinal chemistry, Apr-20, Volume: 49, Issue:8 | Structure-based optimization of azole antifungal agents by CoMFA, CoMSIA, and molecular docking. |
| AID9224 | In vitro antifungal activity against Aspergillus flavus CM74 | 2002 | Journal of medicinal chemistry, Oct-24, Volume: 45, Issue:22 | Synthesis, antifungal activity, and molecular modeling studies of new inverted oxime ethers of oxiconazole. |
| AID405100 | Antimicrobial activity against Absidia corymbifera after 24 hrs | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | In vitro susceptibilities of 217 clinical isolates of zygomycetes to conventional and new antifungal agents. |
| AID642942 | Antifungal activity against fluconazole-resistant Candida albicans isolate 17 isolated from AIDS patient at 160 ug/ml | 2011 | ACS medicinal chemistry letters, May-12, Volume: 2, Issue:5 | Natural Product Based 6-Hydroxy-2,3,4,6-tetrahydropyrrolo[1,2-a]pyrimidinium Scaffold as A New Antifungal Template. |
| AID717775 | Antimicrobial activity against Trichosporon beigelii 1188 after 48 hrs by broth microdilution test | 2012 | Bioorganic & medicinal chemistry, Dec-15, Volume: 20, Issue:24 | Contribution to investigation of antimicrobial activity of styrylquinolines. |
| AID174691 | In vivo evaluation of antifungal activity against vaginal candidosis in rat at dose 0.5 mg/kg on 15th day | 1995 | Journal of medicinal chemistry, Sep-29, Volume: 38, Issue:20 | Synthesis and antifungal activity of new azole derivatives containing an N-acylmorpholine ring. |
| AID1435661 | Antifungal activity against Candida glabrata 20/I after 24 hrs by broth microdilution method | 2017 | European journal of medicinal chemistry, Jan-27, Volume: 126 | S-substituted 3,5-dinitrophenyl 1,3,4-oxadiazole-2-thiols and tetrazole-5-thiols as highly efficient antitubercular agents. |
| AID1312608 | Antifungal activity against naftifine-sensitive Microsporum gypseum after 7 days by serial dilution method | 2016 | Journal of medicinal chemistry, 05-26, Volume: 59, Issue:10 | Discovery of Benzocycloalkane Derivatives Efficiently Blocking Bacterial Virulence for the Treatment of Methicillin-Resistant S. aureus (MRSA) Infections by Targeting Diapophytoene Desaturase (CrtN). |
| AID372233 | Effect on CDR2 RNA level in Candida albicans SSK21 at MIC after 120 mins by RT-PCR | 2007 | Antimicrobial agents and chemotherapy, Oct, Volume: 51, Issue:10 | The Ssk1p response regulator and Chk1p histidine kinase mutants of Candida albicans are hypersensitive to fluconazole and voriconazole. |
| AID1885971 | Antifungal activity against Cryptococcus neoformans clinical isolate HN20 assessed as fungal growth inhibition incubated for 72 hrs by broth microdilution method | |||
| AID405110 | Antimicrobial activity against Absidia sp. assessed as percent of susceptible isolates after 24 hrs | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | In vitro susceptibilities of 217 clinical isolates of zygomycetes to conventional and new antifungal agents. |
| AID1904266 | Antifungal activity against Aspergillus fumigatus 023-2 assessed as inhibition of fungal growth incubated for 48 hrs by microdilution method | 2022 | Journal of medicinal chemistry, 05-12, Volume: 65, Issue:9 | Discovery of Novel Sertraline Derivatives as Potent Anti- |
| AID622959 | Antifungal activity against Candida albicans ATCC 44859 after 24 hrs by microdilution method | 2011 | Bioorganic & medicinal chemistry letters, Oct-15, Volume: 21, Issue:20 | Synthesis and biological activity of desmethoxy analogues of coruscanone A. |
| AID1885974 | Antifungal activity against Cryptococcus neoformans clinical isolate 444 assessed as fungal growth inhibition incubated for 72 hrs by broth microdilution method | |||
| AID1557075 | Antifungal activity against Candida albicans ATCC 90028 assessed as reduction in fungal cell growth incubated for 24 hrs by MTT based broth double dilution method | 2019 | European journal of medicinal chemistry, Oct-01, Volume: 179 | Antifungal activity, mode of action variability, and subcellular distribution of coumarin-based antifungal azoles. |
| AID45512 | Inhibitory effect on Candida albicans YEM13 BENup Strain | 2004 | Journal of medicinal chemistry, Jan-01, Volume: 47, Issue:1 | Folate-synthesizing enzyme system as target for development of inhibitors and inhibitor combinations against Candida albicans-synthesis and biological activity of new 2,4-diaminopyrimidines and 4'-substituted 4-aminodiphenyl sulfones. |
| AID405185 | Antimicrobial activity against Blastoschizomyces capitatus IHEM 16105 isolate by microdilution method | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | Combined therapies in a murine model of blastoschizomycosis. |
| AID419079 | Antifungal activity against Candida albicans ATCC 64550 | 2009 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 19, Issue:7 | Amide analogs of antifungal dioxane-triazole derivatives: synthesis and in vitro activities. |
| AID1380517 | Antifungal activity against Candida albicans Gu5 assessed as inhibition of fungal growth incubated for 48 hrs by broth microdilution assay | 2018 | Bioorganic & medicinal chemistry letters, 06-01, Volume: 28, Issue:10 | Biofilm inhibition and anti-Candida activity of a cationic lipo-benzamide molecule with twin-nonyl chain. |
| AID1689858 | Antifungal activity against Candida albicans CAAL93 infected in Swiss mouse assessed as reduction in kidney fungal burden at 10 mg/kg, po after 14 days | 2020 | European journal of medicinal chemistry, Mar-01, Volume: 189 | New azole antifungals with a fused triazinone scaffold. |
| AID1549169 | Inhibition of HDAC in azole-resistant Candida albicans 0304103 assessed as reduction in MDR1 gene expression at 32 ug/ml after 16 hrs by SYBR Green-1 dye based RT-PCR analysis | 2020 | Journal of medicinal chemistry, 05-28, Volume: 63, Issue:10 | Discovery of Novel Fungal Lanosterol 14α-Demethylase (CYP51)/Histone Deacetylase Dual Inhibitors to Treat Azole-Resistant Candidiasis. |
| AID642933 | Antifungal activity against Candida parapsilosis ATCC 22019 at 160 ug/ml | 2011 | ACS medicinal chemistry letters, May-12, Volume: 2, Issue:5 | Natural Product Based 6-Hydroxy-2,3,4,6-tetrahydropyrrolo[1,2-a]pyrimidinium Scaffold as A New Antifungal Template. |
| AID1506727 | Antifungal activity against Aspergillus niger MTCC 282 | 2017 | MedChemComm, Mar-01, Volume: 8, Issue:3 | Design, synthesis, molecular-docking and antimycobacterial evaluation of some novel 1,2,3-triazolyl xanthenones. |
| AID584589 | Antifungal activity against 15 days cultured Candida glabrata isolated from HSCT recipient with acute or chronic GVHD mouth receiving antifungal therapy for 168 days after 113 days of prophylaxis by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Impact of antifungal prophylaxis on colonization and azole susceptibility of Candida species. |
| AID1487480 | Antifungal activity against Aspergillus flavus assessed as zone of inhibition at 50 ug/ml measured after 24 hrs by well diffusion method | 2017 | Bioorganic & medicinal chemistry letters, 08-15, Volume: 27, Issue:16 | Synthesis, antioxidant, antifungal, molecular docking and ADMET studies of some thiazolyl hydrazones. |
| AID516272 | Antimicrobial activity against Cryptococcus gattii serotype B isolate RB-1 assessed as concentration required for heteroresistance | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Heteroresistance of Cryptococcus gattii to fluconazole. |
| AID555820 | Antifungal activity against Candida albicans STY47 expressing cdr2 gene after 48 hrs | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Relative contributions of the Candida albicans ABC transporters Cdr1p and Cdr2p to clinical azole resistance. |
| AID1911615 | Antifungal activity against Cryptococcus neoformans H99 assessed as fungal growth inhibition by broth microdilution assay | 2022 | Journal of medicinal chemistry, 06-09, Volume: 65, Issue:11 | Development of Lipo-γ-AA Peptides as Potent Antifungal Agents. |
| AID1546089 | Antimicrobial activity against Staphylococcus aureus | 2019 | European journal of medicinal chemistry, Dec-15, Volume: 184 | Current scenario of tetrazole hybrids for antibacterial activity. |
| AID287829 | Antifungal activity against Aspergillus fumigatus 231 after 24 hrs | 2007 | Bioorganic & medicinal chemistry, Apr-15, Volume: 15, Issue:8 | Hybrid molecules of estrone: new compounds with potential antibacterial, antifungal, and antiproliferative activities. |
| AID609970 | Antifungal activity against Aspergillus flavus at 500 ug after 24 hrs by paper disc technique | 2011 | Bioorganic & medicinal chemistry letters, Aug-15, Volume: 21, Issue:16 | Efficient synthesis of antifungal active 9-substituted-3-aryl-5H,13aH-quinolino[3,2-f][1,2,4]triazolo[4,3-b][1,2,4]triazepines in ionic liquids. |
| AID1392821 | Inhibition of Cyp51 in Candida albicans ATCC SC5314 assessed as obtusifoliol content at 8 ug/ml after 16 hrs by GC-MS analysis (Rvb = 0.6%) | 2018 | Bioorganic & medicinal chemistry, 07-23, Volume: 26, Issue:12 | Design, synthesis and evaluation of benzoheterocycle analogues as potent antifungal agents targeting CYP51. |
| AID244978 | In-vitro minimum inhibitory concentration against the growth of Trichophyton mentagrophytes | 2005 | Bioorganic & medicinal chemistry letters, Jul-01, Volume: 15, Issue:13 | Synthesis of (1,4)-naphthoquinono-[3,2-c]-1H-pyrazoles and their (1,4)-naphthohydroquinone derivatives as antifungal, antibacterial, and anticancer agents. |
| AID521986 | Antibacterial activity against Fluconazole resistant Candida albicans DSY3606 containing tac1delta/delta ERG11-1/ERG11-1 (TAC1-5) genotype infected in BALB/c mouse administered intraperitoneally 1 hr post bacterial challenge measured 3 days post infection | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Genetic dissection of azole resistance mechanisms in Candida albicans and their validation in a mouse model of disseminated infection. |
| AID1367154 | Antifungal activity against Candida krusei E28 after 48 hrs by microdilution broth method | 2017 | Bioorganic & medicinal chemistry letters, 12-01, Volume: 27, Issue:23 | Synthesis and biological evolution of hydrazones derived from 4-(trifluoromethyl)benzohydrazide. |
| AID279089 | Antimicrobial activity against Candida tropicalis at 24 hrs | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Association of fluconazole area under the concentration-time curve/MIC and dose/MIC ratios with mortality in nonneutropenic patients with candidemia. |
| AID494224 | Antifungal activity against Aspergillus flavus at 100 ug/ml after 48 hrs by paper disc diffusion technique | 2010 | European journal of medicinal chemistry, Aug, Volume: 45, Issue:8 | Novel 6,8-dibromo-4(3H)quinazolinone derivatives of anti-bacterial and anti-fungal activities. |
| AID285859 | Antimicrobial susceptibility of Pichia anomala from nosocomial fungemia patient assessed as percent susceptible isolates at 2 ug/ml by CLSI method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Antifungal drug susceptibility profile of Pichia anomala isolates from patients presenting with nosocomial fungemia. |
| AID410996 | Antifungal activity against Candida albicans ATCC 10231 after 24 hrs by broth macrodilution method | 2009 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 19, Issue:1 | One-pot synthesis of 5-phenylimino, 5-thieno or 5-oxo-1,2,3-dithiazoles and evaluation of their antimicrobial and antitumor activity. |
| AID737325 | Antimicrobial activity against Aspergillus oryzae MTCC 3567 at 1000 ug/ml after 72 hrs by cup plate method | 2013 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 23, Issue:7 | Synthesis of novel 2-amino-4-(5'-substituted 2'-phenyl-1H-indol-3'-yl)-6-aryl-4H-pyran-3-carbonitrile derivatives as antimicrobial and antioxidant agents. |
| AID405037 | Antifungal activity against Sporothrix schenckii P24255 isolate from cutaneous-lymphatic sporotrichosis patient after 72 hrs by Sensititre YeastOne method | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | In vitro susceptibility of Sporothrix schenckii to six antifungal agents determined using three different methods. |
| AID1279022 | Antifungal activity against Candida albicans ATCC 44859 after 48 hrs by microbroth dilution method | 2016 | Bioorganic & medicinal chemistry, Mar-15, Volume: 24, Issue:6 | Salicylanilide N-monosubstituted carbamates: Synthesis and in vitro antimicrobial activity. |
| AID372423 | Antifungal activity against Candida albicans SC5314 at 32 uM after 16 hrs by BacTiter-Glow assay | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Galanin message-associated peptide suppresses growth and the budded-to-hyphal-form transition of Candida albicans. |
| AID1456587 | Antimicrobial activity against Candida albicans after 18 to 24 hrs by agar well-diffusion method | 2017 | Bioorganic & medicinal chemistry letters, 05-15, Volume: 27, Issue:10 | Novel quinoxalinyl chalcone hybrid scaffolds as enoyl ACP reductase inhibitors: Synthesis, molecular docking and biological evaluation. |
| AID766646 | Antifungal activity against Candida albicans MTCC 3018 after 24 hrs by well diffusion method | 2013 | European journal of medicinal chemistry, Sep, Volume: 67 | Total synthesis and biological evaluation of clavaminol-G and its analogs. |
| AID582784 | Antifungal activity against Candida albicans isolate 6 assessed as lanosterol/obtusifoliol content in total sterol composition at 0.5 times MIC by GC-MS analysis | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | Identification and characterization of four azole-resistant erg3 mutants of Candida albicans. |
| AID609966 | Antifungal activity against Aspergillus niger at 500 ug after 24 hrs by paper disc technique | 2011 | Bioorganic & medicinal chemistry letters, Aug-15, Volume: 21, Issue:16 | Efficient synthesis of antifungal active 9-substituted-3-aryl-5H,13aH-quinolino[3,2-f][1,2,4]triazolo[4,3-b][1,2,4]triazepines in ionic liquids. |
| AID1698047 | Antifungal activity against Saccharomyces cerevisiae assessed as inhibition of fungal growth incubated for 24 hrs by agar well diffusion method | 2020 | Bioorganic & medicinal chemistry letters, 11-15, Volume: 30, Issue:22 | Design and synthesis of new indanol-1,2,3-triazole derivatives as potent antitubercular and antimicrobial agents. |
| AID1487216 | Inhibition of CYP51 in Candida glabrata assessed as inhibition of microbe growth incubated for 48 hrs by CLSI M27-A3 guideline based method | 2017 | Bioorganic & medicinal chemistry letters, 08-01, Volume: 27, Issue:15 | Design and optimization of highly-selective, broad spectrum fungal CYP51 inhibitors. |
| AID448700 | Antimicrobial activity against Candida tropicalis ATCC 1369 after 24 hrs by broth microdilution method | 2009 | European journal of medicinal chemistry, Nov, Volume: 44, Issue:11 | Synthesis of new 4-isopropylthiazole hydrazide analogs and some derived clubbed triazole, oxadiazole ring systems--a novel class of potential antibacterial, antifungal and antitubercular agents. |
| AID670550 | Antifungal activity against Candida parapsilosis MTCC 1744 after 24 hrs by well diffusion method | 2012 | Bioorganic & medicinal chemistry letters, Jul-15, Volume: 22, Issue:14 | Total synthesis and antifungal activity of (2S,3R)-2-aminododecan-3-ol. |
| AID518699 | Antimicrobial activity against Cryptococcus gattii serotype C isolate NIH113 assessed as heteroresistant isolates at 16 ug/ml | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Heteroresistance of Cryptococcus gattii to fluconazole. |
| AID1898173 | Antifungal activity against Candida krusei 397 | |||
| AID528082 | Antimicrobial activity against Cryptococcus neoformans by broth microdilution method | 2010 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 20, Issue:22 | Stereocontrolled facile synthesis and antimicrobial activity of oximes and oxime ethers of diversely substituted bispidines. |
| AID494223 | Antifungal activity against Candida albicans after 48 hrs by agar streak dilution method | 2010 | European journal of medicinal chemistry, Aug, Volume: 45, Issue:8 | Novel 6,8-dibromo-4(3H)quinazolinone derivatives of anti-bacterial and anti-fungal activities. |
| AID555824 | Ratio of MIC50 for Candida albicans 5674 to MIC50 for Candida albicans STY47 expressing cdr2 gene | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Relative contributions of the Candida albicans ABC transporters Cdr1p and Cdr2p to clinical azole resistance. |
| AID584595 | Antifungal activity against 176 days cultured Candida glabrata isolated from HSCT recipient with acute or chronic GVHD mouth receiving antifungal therapy for 172 days after 114 days of prophylaxis by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Impact of antifungal prophylaxis on colonization and azole susceptibility of Candida species. |
| AID1192373 | Antimicrobial activity against Xanthomonas campestris after 18 hrs by broth micro dilution method | 2015 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 25, Issue:7 | Synthesis and antimicrobial activity of novel benzoxazine sulfonamide derivatives. |
| AID568478 | Antifungal activity against Candida krusei KCCM 11655 after 1 day by twofold broth dilution method | 2011 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 21, Issue:3 | Synthesis and antifungal activity of furo[2,3-f]quinolin-5-ols. |
| AID279110 | Mortality rate stratified by 24 hrs MIC in resistant Candida species infected patient | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Association of fluconazole area under the concentration-time curve/MIC and dose/MIC ratios with mortality in nonneutropenic patients with candidemia. |
| AID1474166 | Liver toxicity in human assessed as induction of drug-induced liver injury by measuring severity class index | 2016 | Drug discovery today, Apr, Volume: 21, Issue:4 | DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. |
| AID1379747 | Antimicrobial activity against Candida albicans incubated for 48 hrs by disc diffusion assay | 2017 | European journal of medicinal chemistry, Nov-10, Volume: 140 | Synthesis, antimicrobial, antiquorum-sensing, antitumor and cytotoxic activities of new series of cyclopenta(hepta)[b]thiophene and fused cyclohepta[b]thiophene analogs. |
| AID1471216 | Antifungal activity against Trichophyton mentagrophytes by spectrophotometric method | 2017 | Bioorganic & medicinal chemistry letters, 07-01, Volume: 27, Issue:13 | Diversity-oriented sustainable synthesis of antimicrobial spiropyrrolidine/thiapyrrolizidine oxindole derivatives: New ligands for a metallo-β-lactamase from Klebsiella pneumonia. |
| AID49805 | Fungicidal versus fungistatic activity of bifunctional sphingolipids against Candida glabrata at a concentration of 0.3 ug/mL before dilution replating; growth in media | 2002 | Bioorganic & medicinal chemistry letters, Aug-19, Volume: 12, Issue:16 | Antifungal activity of bifunctional sphingolipids. Intramolecular synergism within long-chain alpha,omega-bis-aminoalcohols. |
| AID141790 | Minimum inhibitory concentration of compound for antifungal activity against Mucosporam canis | 2000 | Bioorganic & medicinal chemistry letters, Oct-02, Volume: 10, Issue:19 | Novel antifungals based on 4-substituted imidazole: a combinatorial chemistry approach to lead discovery and optimization. |
| AID582225 | Antifungal activity against Candida glabrata isolated from HSCT recipients with acute or chronic GVHD receiving posaconazole assessed as maximum MIC by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Impact of antifungal prophylaxis on colonization and azole susceptibility of Candida species. |
| AID1904361 | Antifungal activity against Candida glabrata clinical isolate assessed as fungal growth inhibition by CLSI based serial microbroth dilution method | 2022 | European journal of medicinal chemistry, Apr-05, Volume: 233 | Design, synthesis, and evaluation of novel 3-thiophene derivatives as potent fungistatic and fungicidal reagents based on a conformational restriction strategy. |
| AID1193894 | Antifungal activity against Candida tropicalis MTCC 183 after 48 hrs by broth dilution method | 2015 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 25, Issue:7 | Rapid 'one-pot' synthesis of a novel benzimidazole-5-carboxylate and its hydrazone derivatives as potential anti-inflammatory and antimicrobial agents. |
| AID1494179 | Antifungal activity against fluconazole/ITC-resistant Candida albicans ATCC MYA-1003 measured after 48 hrs by CLSI M27-A3 protocol based method | 2018 | Bioorganic & medicinal chemistry, 02-01, Volume: 26, Issue:3 | Novel fluconazole derivatives with promising antifungal activity. |
| AID1556214 | Antifungal activity against fluconazole-resistant Candida albicans Strain CaR assessed as inhibition of visible microbial growth by NCCLS protocol based method | 2019 | European journal of medicinal chemistry, Sep-01, Volume: 177 | Design, synthesis, and structure-activity relationship studies of l-amino alcohol derivatives as broad-spectrum antifungal agents. |
| AID1877441 | Antifungal activity against Candida albicans | 2022 | Bioorganic & medicinal chemistry letters, 01-01, Volume: 55 | New bis- and tetrakis-1,2,3-triazole derivatives: Synthesis, DNA cleavage, molecular docking, antimicrobial, antioxidant activity and acid dissociation constants. |
| AID340954 | Antifungal activity against Candida glabrata ATCC 90030 by NCCLS M27-A2 method | 2007 | Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8 | Cross-resistance to medical and agricultural azole drugs in yeasts from the oropharynx of human immunodeficiency virus patients and from environmental Bavarian vine grapes. |
| AID1124798 | Antifungal activity against Cryptococcus neoformans clinical isolate after 24 to 48 hrs by standard broth microdilution method | 2014 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 24, Issue:7 | Synthesis and evaluation of new diaryl ether and quinoline hybrids as potential antiplasmodial and antimicrobial agents. |
| AID424620 | Antimicrobial activity against azole-susceptible Candida albicans isolate CA12 after 48 hrs by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | In vitro interactions between tacrolimus and azoles against Candida albicans determined by different methods. |
| AID1651344 | Antifungal activity against Candida albicans Y0109 by NCCLS protocol based broth microdilution assay | 2020 | Bioorganic & medicinal chemistry letters, 02-15, Volume: 30, Issue:4 | Design, synthesis, and structure-activity relationship studies of novel triazole agents with strong antifungal activity against Aspergillus fumigatus. |
| AID1859328 | Antimicrobial activity against Candida tropicalis 895 | 2022 | Journal of medicinal chemistry, 02-24, Volume: 65, Issue:4 | Application of the All-Hydrocarbon Stapling Technique in the Design of Membrane-Active Peptides. |
| AID531096 | Binding affinity to Candida albicans CYP56 by spectrophotometry | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | CYP56 (Dit2p) in Candida albicans: characterization and investigation of its role in growth and antifungal drug susceptibility. |
| AID564276 | Antifungal activity against Candida albicans isolate 108 harboring erg11 and erg5 double mutant after 48 hrs by broth microdilution method in presence of 10 uM of efflux pump inhibitor FK506 | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | A clinical isolate of Candida albicans with mutations in ERG11 (encoding sterol 14alpha-demethylase) and ERG5 (encoding C22 desaturase) is cross resistant to azoles and amphotericin B. |
| AID1885980 | Antifungal activity against Cryptococcus gattii WM178 assessed as fungal growth inhibition incubated for 72 hrs in presence of P163-0892 by broth microdilution method | |||
| AID1852895 | Inhibition of candida albicans CYP51 using 7-ethoxyresorufin as fluorescent substrate incubated for 10 mins in the presence of NADPH by fluorescence based spectroscopic microtiter plate reader analysis | 2022 | RSC medicinal chemistry, Nov-16, Volume: 13, Issue:11 | Efficient selective targeting of |
| AID407019 | Antimicrobial activity against Chk1 deficient Candida albicans CHK21 at planktonic cell density of 10'8 cells/ml after 48 hrs by XTT assay | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | Role for cell density in antifungal drug resistance in Candida albicans biofilms. |
| AID602930 | Antifungal activity against Candida kefyr by micro-broth dilution method | 2011 | European journal of medicinal chemistry, Jul, Volume: 46, Issue:7 | Design, synthesis and antifungal evaluation of 1-(2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propyl)-1H-1,2,4-triazol-5(4H)-one. |
| AID665071 | Antifungal activity against Candida krusei after 24 hrs by serial dilution method | 2012 | European journal of medicinal chemistry, Jul, Volume: 53 | Design, synthesis and structure-activity relationships of new triazole derivatives containing N-substituted phenoxypropylamino side chains. |
| AID712898 | Antifungal activity against Aspergillus flavus after 72 hrs by agar disk diffusion method | 2012 | European journal of medicinal chemistry, Aug, Volume: 54 | Synthesis and evaluation of antimicrobial activity of 4H-pyrimido[2,1-b]benzothiazole, pyrazole and benzylidene derivatives of curcumin. |
| AID521793 | Fungistatic activity against Candida parapsilosis ATCC 22019 assessed as 99.9% reduction of int initial fungal load at 0.5 times MIC after 48 hrs using colony count method by time-kill method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Posaconazole against Candida glabrata isolates with various susceptibilities to fluconazole. |
| AID1911668 | Effect on CDR2 gene transcription level in Candida albicans CARG5 at 8 ug/ml incubated for 3 hrs by qRT-PCR analysis | 2022 | Journal of medicinal chemistry, 06-09, Volume: 65, Issue:11 | Development of Lipo-γ-AA Peptides as Potent Antifungal Agents. |
| AID470597 | Antifungal activity against Cryptococcus neoformans after 72 hrs by microbroth dilution technique | 2009 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 19, Issue:18 | Design and synthesis of bile acid-based amino sterols as antimicrobial agents. |
| AID1394706 | Antifungal activity against fluconazole-resistant Candida albicans NUH-K6004 after overnight incubation by CLSI broth microdilution method | 2018 | European journal of medicinal chemistry, Apr-25, Volume: 150 | Structure-activity relationship studies of ultra-short peptides with potent activities against fluconazole-resistant Candida albicans. |
| AID1419553 | Selectivity index, ratio of EC50 for toxicity in human A549 cells to MIC50 for antifungal activity against Candida glabrata ATCC 2001 | 2017 | European journal of medicinal chemistry, Jun-16, Volume: 133 | Novel alkylated azoles as potent antifungals. |
| AID521970 | Antibacterial activity against Fluconazole resistant Candida albicans DSY3752 containing (TAC1-5/TAC1-5 ERG11-1/ERG11-1) genotype by EUCAST standards based broth microdilution method sCandida albicans DSY294 | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Genetic dissection of azole resistance mechanisms in Candida albicans and their validation in a mouse model of disseminated infection. |
| AID1624183 | Antifungal activity against Candida glabrata ATCC 90030 after 24 hrs by microbroth dilution method | 2019 | Bioorganic & medicinal chemistry letters, 03-01, Volume: 29, Issue:5 | Benzimidazole tethered pyrrolo[3,4-b]quinoline with broad-spectrum activity against fungal pathogens. |
| AID1886038 | Synergistic antifungal activity against Cryptococcus neoformans clinical isolate 56992 assessed as fractional inhibitory concentration index incubated for 72 hrs in presence of P163-0892 by broth microdilution method | |||
| AID419637 | Antifungal activity against Aspergillus niger after 7 days by tube dilution method | 2009 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 19, Issue:11 | Synthesis, antimicrobial activity and QSAR studies of new 2,3-disubstituted-3,3a,4,5,6,7-hexahydro-2H-indazoles. |
| AID626347 | Antifungal activity against Aspergillus flavus MTCC 3306 at 0.25 mg/mL after 72 hrs by by agar-well diffusion method | 2011 | European journal of medicinal chemistry, Nov, Volume: 46, Issue:11 | Hantzsch reaction: synthesis and characterization of some new 1,4-dihydropyridine derivatives as potent antimicrobial and antioxidant agents. |
| AID1392819 | Inhibition of Cyp51 in Candida albicans ATCC SC5314 assessed as obtusifoliol content at 0.5 ug/ml after 16 hrs by GC-MS analysis (Rvb = 0.6%) | 2018 | Bioorganic & medicinal chemistry, 07-23, Volume: 26, Issue:12 | Design, synthesis and evaluation of benzoheterocycle analogues as potent antifungal agents targeting CYP51. |
| AID1079939 | Cirrhosis, proven histopathologically. Value is number of references indexed. [column 'CIRRH' in source] | |||
| AID388081 | Antifungal activity at Candida albicans | 2008 | Bioorganic & medicinal chemistry letters, Oct-15, Volume: 18, Issue:20 | Synthesis of chimeric tetrapeptide-linked cholic acid derivatives: impending synergistic agents. |
| AID595735 | Antimicrobial activity against Candida albicans after 48 hrs by broth microdilution method | 2011 | European journal of medicinal chemistry, May, Volume: 46, Issue:5 | Design, synthesis and in vitro antimicrobial evaluation of novel Imidazo[1,2-a]pyridine and imidazo[2,1-b][1,3]benzothiazole motifs. |
| AID1494148 | Antifungal activity against Candida albicans SCY0109 after 24 hrs | 2018 | European journal of medicinal chemistry, Jan-01, Volume: 143 | Molecular docking, design, synthesis and antifungal activity study of novel triazole derivatives. |
| AID1494192 | Antifungal activity against Cryptococcus neoformans isolate CN3 measured after 48 hrs by CLSI M27-A3 protocol based method | 2018 | Bioorganic & medicinal chemistry, 02-01, Volume: 26, Issue:3 | Novel fluconazole derivatives with promising antifungal activity. |
| AID420071 | Antifungal activity against Candida krusei after 48 hrs by broth microdilution assay | 2009 | Bioorganic & medicinal chemistry, Jun-01, Volume: 17, Issue:11 | Bulky 1,4-benzoxazine derivatives with antifungal activity. |
| AID1328360 | Selectivity index, ratio of IC50 for African green monkey Vero cells to MIC for Cryptococcus neoformans ATCC 90113 | 2016 | Journal of natural products, 09-23, Volume: 79, Issue:9 | Synthesis of Natural Acylphloroglucinol-Based Antifungal Compounds against Cryptococcus Species. |
| AID1904375 | Inhibition of CYP51 in Candida albicans ATCC SC5314 assessed as 14alpha-methylergosta-8,24(28)-dien-3beta-6alpha-diol level at 0.25 ug/ml measured after 18 hrs by GC-MS analysis relative to control | 2022 | European journal of medicinal chemistry, Apr-05, Volume: 233 | Design, synthesis, and evaluation of novel 3-thiophene derivatives as potent fungistatic and fungicidal reagents based on a conformational restriction strategy. |
| AID598226 | Antimicrobial activity against Candida krusei isolate 31 after 48 hrs by microdilution broth method | 2011 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 21, Issue:11 | Synthesis and in vitro antimicrobial activities of new (cyano-NNO-azoxy)pyrazole derivatives. |
| AID440353 | Antifungal activity against Aspergillus fumigatus NCIM 902 after 2 to 3 days by serial plate dilution method | 2009 | European journal of medicinal chemistry, Dec, Volume: 44, Issue:12 | Synthesis and antimicrobial activity of some new N-acyl substituted phenothiazines. |
| AID588213 | Literature-mined compound from Fourches et al multi-species drug-induced liver injury (DILI) dataset, effect in non-rodents | 2010 | Chemical research in toxicology, Jan, Volume: 23, Issue:1 | Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. |
| AID606214 | Antifungal activity against Candida tropicalis by micro-broth dilution method | 2011 | European journal of medicinal chemistry, Jul, Volume: 46, Issue:7 | Design, synthesis and antifungal activities of novel 1,2,4-triazole derivatives. |
| AID440313 | Anticandidal activity against Candida krusei 193T after 24 hrs by spectrophotometry | 2009 | Journal of medicinal chemistry, Dec-10, Volume: 52, Issue:23 | Synthesis of new linear guanidines and macrocyclic amidinourea derivatives endowed with high antifungal activity against Candida spp. and Aspergillus spp. |
| AID1126881 | Antifungal activity against Candida albicans ATCC 10231 assessed as growth inhibition after 18 hrs by two-fold serial dilution method | 2014 | European journal of medicinal chemistry, May-06, Volume: 78 | Searching for new derivatives of neocryptolepine: synthesis, antiproliferative, antimicrobial and antifungal activities. |
| AID1918347 | Increase in intracellular ROS level in Cryptococcus neoformans assessed as fold increase in fluorescence intensity measured after 12 hrs by fluorescence microscopic analysis relative to control | 2022 | Journal of medicinal chemistry, 11-10, Volume: 65, Issue:21 | Novel Aryl Alkamidazole Derivatives as Multifunctional Antifungal Inhibitors: Design, Synthesis, and Biological Evaluation. |
| AID750763 | Antifungal activity against Curvularia lunata MTCC 581 assessed as zone of inhibition at 40 uM after 48 hrs by disc diffusion method | 2013 | European journal of medicinal chemistry, Jun, Volume: 64 | Biological activity, design, synthesis and structure activity relationship of some novel derivatives of curcumin containing sulfonamides. |
| AID283205 | Antimicrobial activity against Candida glabrata 21231 isolate by E-test | 2007 | Antimicrobial agents and chemotherapy, Mar, Volume: 51, Issue:3 | Reduced susceptibility to polyenes associated with a missense mutation in the ERG6 gene in a clinical isolate of Candida glabrata with pseudohyphal growth. |
| AID518449 | Antimicrobial activity against Cryptococcus gattii serotype B isolate RAM15 assessed as heteroresistant isolates at 4 ug/ml | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Heteroresistance of Cryptococcus gattii to fluconazole. |
| AID1246672 | Antifungal activity against Cryptococcus neoformans ATCC 62066 assessed as reduction in cell viability at 26 uM after 6 to 72 hrs by MTT assay | 2015 | European journal of medicinal chemistry, Sep-18, Volume: 102 | Thiazole compounds with activity against Cryptococcus gattii and Cryptococcus neoformans in vitro. |
| AID581865 | Antifungal activity against Candida albicans isolated from HSCT recipient 262 with acute or chronic GVHD mouth receiving antifungal drug after 115 days prophylaxis by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Impact of antifungal prophylaxis on colonization and azole susceptibility of Candida species. |
| AID1157185 | Antifungal activity against Candida glabrata PMC 0853R after 48 hrs by CLSI broth microdilution method | 2014 | European journal of medicinal chemistry, Aug-18, Volume: 83 | Synthesis, biological evaluation and structure-activity correlation study of a series of imidazol-based compounds as Candida albicans inhibitors. |
| AID1737523 | Antifungal activity against Cryptococcus neoformans ATCC 32719 incubated for 48 hrs by two-fold broth dilution analysis | 2020 | European journal of medicinal chemistry, Jun-01, Volume: 195 | Design, synthesis and biological evaluation of novel 3,4-dihydro-2(1H)-quinolinone derivatives as potential chitin synthase inhibitors and antifungal agents. |
| AID1609924 | Antifungal activity against fluconazole-resistant Candida albicans CaR assessed as reduction in fungal growth incubated for 24 hrs by serial dilution method | |||
| AID551060 | Antifungal activity against Cryptococcus neoformans assessed as appearance of macroscopically visible colonies after 48 and 72 hrs by standard agar dilution method | 2011 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 21, Issue:1 | Microwave assisted one pot synthesis of some novel 2,5-disubstituted 1,3,4-oxadiazoles as antifungal agents. |
| AID594939 | Antimicrobial activity against Candida tropicalis after 24 hrs by NCCLS method | 2011 | European journal of medicinal chemistry, May, Volume: 46, Issue:5 | Design and synthesis of antifungal benzoheterocyclic derivatives by scaffold hopping. |
| AID518132 | Antimicrobial activity against Cryptococcus gattii serotype B isolate RB-13 assessed as concentration required for heteroresistance | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Heteroresistance of Cryptococcus gattii to fluconazole. |
| AID405038 | Antifungal activity against Sporothrix schenckii P24255 isolate from cutaneous-lymphatic sporotrichosis patient after 72 hrs by ATB Fungus 2 method | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | In vitro susceptibility of Sporothrix schenckii to six antifungal agents determined using three different methods. |
| AID1192372 | Antimicrobial activity against Bacillus megaterium MTCC 3382 after 18 hrs by broth micro dilution method | 2015 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 25, Issue:7 | Synthesis and antimicrobial activity of novel benzoxazine sulfonamide derivatives. |
| AID1361018 | Antifungal activity against Candida albicans MTCC 3958 assessed as zone of growth inhibition after 48 hrs | 2018 | European journal of medicinal chemistry, Jul-15, Volume: 155 | Rational modification of a lead molecule: Improving the antifungal activity of indole - triazole - amino acid conjugates. |
| AID1742132 | Antifungal activity against fluconazole-resistant Candida albicans CaR assessed as inhibition of microbial growth by two fold broth microdilution method | 2020 | European journal of medicinal chemistry, Nov-01, Volume: 205 | Design, synthesis and bioactivity evaluation of novel arylalkene-amide derivatives as dual-target antifungal inhibitors. |
| AID1864872 | Toxicity in mouse infected with Candida albicans assessed as liver injury at 10 ug per 20 g, ip administered on day 2, 4, 6, 8, 10 and 12 and measured on day 14 by H and E staining based assay | |||
| AID1872496 | Antifungal activity against Candida parapsilosis | 2022 | European journal of medicinal chemistry, Mar-05, Volume: 231 | Synthetic approaches and structural diversity of triazolylbutanols derived from voriconazole in the antifungal drug development. |
| AID1918349 | Induction of mitochondrial membrane depolarization in Candida albicans assessed as fungal cells with intact mitochondria measured after 24 hrs by JC-1 staining based flow cytometry (Rvb = 95.9%) | 2022 | Journal of medicinal chemistry, 11-10, Volume: 65, Issue:21 | Novel Aryl Alkamidazole Derivatives as Multifunctional Antifungal Inhibitors: Design, Synthesis, and Biological Evaluation. |
| AID1888265 | Antifungal activity against fluconazole resistant Candida albicans strain 103 assessed as fungal growth inhibition measured after 72 hrs by CLSI protocol based liquid medium dilution method | |||
| AID625279 | Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for bilirubinemia | 2011 | PLoS computational biology, Dec, Volume: 7, Issue:12 | Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). |
| AID1546135 | Antimicrobial activity against Pseudomonas aeruginosa ATCC 27853 after 24 hrs by two-fold broth serial dilution method | 2019 | European journal of medicinal chemistry, Dec-15, Volume: 184 | Current scenario of tetrazole hybrids for antibacterial activity. |
| AID1595047 | Antifungal activity against Candida krusei assessed as reduction in fungal cell growth incubated for 48 hrs by broth microdilution method | 2019 | European journal of medicinal chemistry, May-15, Volume: 170 | Tetrazole hybrids and their antifungal activities. |
| AID1689210 | Antifungal activity against Candida albicans ATCC 10231 assessed as reduction in fungal growth incubated for 24 hrs by CLSI based broth microdilution method | 2020 | European journal of medicinal chemistry, Mar-01, Volume: 189 | Oxadiazolylthiazoles as novel and selective antifungal agents. |
| AID1551789 | Antifungal activity against Aspergillus niger | 2019 | European journal of medicinal chemistry, Jul-01, Volume: 173 | Antibacterial activity study of 1,2,4-triazole derivatives. |
| AID1556211 | Antifungal activity against Candida tropicalis CGMCC 2.3739 assessed as inhibition of visible microbial growth by NCCLS protocol based method | 2019 | European journal of medicinal chemistry, Sep-01, Volume: 177 | Design, synthesis, and structure-activity relationship studies of l-amino alcohol derivatives as broad-spectrum antifungal agents. |
| AID1154028 | Antifungal activity against Candida albicans ATCC 76615 after 48 hrs by disc diffusion method | 2014 | Bioorganic & medicinal chemistry, Jul-01, Volume: 22, Issue:13 | Design, synthesis and evaluation of novel quinazoline-2,4-dione derivatives as chitin synthase inhibitors and antifungal agents. |
| AID424903 | Antimicrobial activity against azole-resistant Candida albicans isolate CA10 assessed as growth at 2 ug/ml cotreated with 0.008 ug/ml calcineurin signaling inhibitor Tacrolimus after 48 hrs by microdilution checkboard technique relative to control | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | In vitro interactions between tacrolimus and azoles against Candida albicans determined by different methods. |
| AID1391616 | Antifungal activity against drug-resistant Candida albicans 28J after 48 hrs by broth microdilution method | 2018 | Bioorganic & medicinal chemistry letters, 05-15, Volume: 28, Issue:9 | Diversity-oriented synthesis of pyrazoles derivatives from flavones and isoflavones leads to the discovery of promising reversal agents of fluconazole resistance in Candida albicans. |
| AID285869 | Antimicrobial susceptibility of Pichia anomala from nosocomial fungemia patient assessed as percent susceptible isolates at 1 ug/ml by EUCAST method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Antifungal drug susceptibility profile of Pichia anomala isolates from patients presenting with nosocomial fungemia. |
| AID424635 | Antimicrobial activity against azole-resistant Candida albicans isolate CA16 cotreated with calcineurin signaling inhibitor Tacrolimus after 48 hrs by microdilution checkerboard technique | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | In vitro interactions between tacrolimus and azoles against Candida albicans determined by different methods. |
| AID1551803 | Antibacterial activity against Pseudomonas aeruginosa ATCC 27853 after 24 hrs by microdilution method | 2019 | European journal of medicinal chemistry, Jul-01, Volume: 173 | Antibacterial activity study of 1,2,4-triazole derivatives. |
| AID545277 | Antifungal activity against Aspergillus fumigatus 231 after 48 hrs by broth microdilution method | 2010 | European journal of medicinal chemistry, Dec, Volume: 45, Issue:12 | New amino acid esters of salicylanilides active against MDR-TB and other microbes. |
| AID1818273 | Antifungal activity against Aspergillus fumigatus KM8001 assessed as reduction in fungal growth incubated for 72 hrs by CLSI protocol based broth microdilution method | |||
| AID518657 | Antimicrobial activity against Cryptococcus gattii serotype B isolate NIH190 assessed as heteroresistant isolates at 8 ug/ml | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Heteroresistance of Cryptococcus gattii to fluconazole. |
| AID1689820 | Antifungal activity against fluconazole-resistant Candida krusei CAKR8 assessed as reduction in microbial growth after 24 hrs by resazurin staining based spectrofluorometric method | 2020 | European journal of medicinal chemistry, Mar-01, Volume: 189 | New azole antifungals with a fused triazinone scaffold. |
| AID405199 | Antimicrobial activity against Blastoschizomyces capitatus IHEM 16105 isolate infected OF1 mouse blastoschizomycosis model assessed as kidney microbial count per gram of tissue at 80 mg/kg/day, po for 6 days administered 1 hr before microbial challenge | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | Combined therapies in a murine model of blastoschizomycosis. |
| AID1898172 | Antifungal activity against Candida krusei 629 | |||
| AID582807 | Antifungal activity against Candida albicans isolate 488 harboring ERG3 H243N, T330A, A351V and ERG11 D225G, E266D, E391G, V488I mutant genes by broth microdilution method in presence of 10 uM drug efflux inhibitor FK506 | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | Identification and characterization of four azole-resistant erg3 mutants of Candida albicans. |
| AID1337063 | Antifungal activity against fluconazole-resistant Candida albicans clinical isolate 17 | 2017 | ACS medicinal chemistry letters, Feb-09, Volume: 8, Issue:2 | Potent Antifungal Synergy of Phthalazinone and Isoquinolones with Azoles Against |
| AID1352421 | Antifungal activity against Candida albicans ATCC 76615 by CLSI two fold serial dilution method | 2018 | European journal of medicinal chemistry, Feb-25, Volume: 146 | Discovery of 2-aminothiazolyl berberine derivatives as effectively antibacterial agents toward clinically drug-resistant Gram-negative Acinetobacter baumanii. |
| AID1904395 | Cytotoxicity against human HepG2 cells assessed as reduction in cell viability incubated for 96 hrs by MTT assay | 2022 | European journal of medicinal chemistry, Apr-05, Volume: 233 | Design, synthesis, and evaluation of novel 3-thiophene derivatives as potent fungistatic and fungicidal reagents based on a conformational restriction strategy. |
| AID372425 | Antifungal activity against Candida albicans clinical isolates at 32 uM after 16 hrs by BacTiter-Glow assay | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Galanin message-associated peptide suppresses growth and the budded-to-hyphal-form transition of Candida albicans. |
| AID542095 | Antifungal activity against Aspergillus fumigatus ATCC 36607 after 24 hrs by microdilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Discovery of a small-molecule inhibitor of {beta}-1,6-glucan synthesis. |
| AID469169 | Antifungal activity against Cryptococcus neoformans | 2010 | European journal of medicinal chemistry, Feb, Volume: 45, Issue:2 | Synthesis, anti-bacterial and anti-fungal activities of some novel Schiff bases containing 2,4-disubstituted thiazole ring. |
| AID1737527 | Antifungal activity against Aspergillus fumigatus GIMCC 3.19 incubated for 48 hrs by two-fold broth dilution analysis | 2020 | European journal of medicinal chemistry, Jun-01, Volume: 195 | Design, synthesis and biological evaluation of novel 3,4-dihydro-2(1H)-quinolinone derivatives as potential chitin synthase inhibitors and antifungal agents. |
| AID518872 | Antimicrobial activity against Cryptococcus gattii serotype C isolate H0058-1-78 assessed as heteroresistant isolates at 16 ug/ml | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Heteroresistance of Cryptococcus gattii to fluconazole. |
| AID682798 | Antifungal activity against Aspergillus fumigatus after 72 hrs by broth microdilution method | 2012 | European journal of medicinal chemistry, Oct, Volume: 56 | Micelles catalyzed chemo- and regio-selective one pot and one step synthesis of 2,3,5,6-tetrakis(alkyl and arylsulfanyl)-1,4-benzoquinones and 2,5-diaminosubstituted-1,4-benzoquinones "In-Water" and their biological evaluation as antibacterial and antifun |
| AID1898159 | Antifungal activity against Candida albicans 12# | |||
| AID563133 | Antifungal activity against Candida glabrata ATCC 90030 infected in ICR mouse assessed as fungal load in kidney at 10 mg/kg/day, sc for 8 days measured on day 9 | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | T-2307 shows efficacy in a murine model of Candida glabrata infection despite in vitro trailing growth phenomena. |
| AID717788 | Antimicrobial activity against Absidia corymbifera 272 after 24 hrs by broth microdilution test | 2012 | Bioorganic & medicinal chemistry, Dec-15, Volume: 20, Issue:24 | Contribution to investigation of antimicrobial activity of styrylquinolines. |
| AID1157166 | Antifungal activity against Cryptococcus neoformans PMC 2103 after 72 hrs by CLSI broth microdilution method | 2014 | European journal of medicinal chemistry, Aug-18, Volume: 83 | Synthesis, biological evaluation and structure-activity correlation study of a series of imidazol-based compounds as Candida albicans inhibitors. |
| AID1367041 | Antifungal activity against Candida albicans ATCC 90023 after 24 hrs by micro broth dilution method | 2017 | Bioorganic & medicinal chemistry, 12-15, Volume: 25, Issue:24 | Discovery of novel nitroimidazole enols as Pseudomonas aeruginosa DNA cleavage agents. |
| AID154275 | In vitro inhibition of cytochrome P450 lanosterol C14 demethylase in Candida albicans CY1005 (experiment 1) | 1998 | Bioorganic & medicinal chemistry letters, Jul-21, Volume: 8, Issue:14 | Modeling, synthesis and biological activity of novel antifungal agents (1). |
| AID1864944 | Inhibition of CYP51 in Candida albicans ATCC SC5314 assessed as lanosterol level at 4 ug/ml incuabted for 48 hrs by GC-MS analysis relative to control | |||
| AID1898176 | Antifungal activity against Candida auris 791 | |||
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| AID42672 | In vitro minimum fungicidal concentration against Candida albicans. | 2001 | Journal of medicinal chemistry, May-24, Volume: 44, Issue:11 | Diguanidino and "reversed" diamidino 2,5-diarylfurans as antimicrobial agents. |
| AID407014 | Antimicrobial activity against Cdr1, Cdr2 and Mdr1 deficient Candida albicans DSY1050 at planktonic cell density of 10'8 cells/ml after 48 hrs by XTT assay | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | Role for cell density in antifungal drug resistance in Candida albicans biofilms. |
| AID486717 | Antifungal activity against Aspergillus niger DSMZ 737 after 24 hrs by macrodilution method | 2010 | European journal of medicinal chemistry, Jun, Volume: 45, Issue:6 | Design, synthesis and determination of antifungal activity of 5(6)-substituted benzotriazoles. |
| AID1444346 | Antifungal activity against Aspergillus fumigatus 231 after 24 hrs by broth microdilution method | 2017 | European journal of medicinal chemistry, Apr-21, Volume: 130 | Structure-activity relationship studies on 3,5-dinitrophenyl tetrazoles as antitubercular agents. |
| AID1295328 | Antifungal activity against Trichophyton mentagrophytes after 48 hrs by broth microdilution method | 2016 | European journal of medicinal chemistry, Jun-10, Volume: 115 | Role of disulfide linkage in action of bis(dialkylaminethiocarbonyl)disulfides as potent double-Edged microbicidal spermicide: Design, synthesis and biology. |
| AID1783069 | Antifungal activity against fluconazole-sensitive Candida albicans 10061 assessed as inhibition of fungal growth | 2021 | European journal of medicinal chemistry, Oct-05, Volume: 221 | Lanosterol 14α-demethylase (CYP51)/histone deacetylase (HDAC) dual inhibitors for treatment of Candida tropicalis and Cryptococcus neoformans infections. |
| AID1859327 | Antimicrobial activity against Candida tropicalis ATCC 20026 | 2022 | Journal of medicinal chemistry, 02-24, Volume: 65, Issue:4 | Application of the All-Hydrocarbon Stapling Technique in the Design of Membrane-Active Peptides. |
| AID1738701 | Antifungal activity against Candida albicans ATCC SC5314 measured after 24 hrs by micro-broth dilution assay | 2020 | European journal of medicinal chemistry, Jul-15, Volume: 198 | Design, synthesis, and biological evaluation of novel miconazole analogues containing selenium as potent antifungal agents. |
| AID526814 | Antifungal activity against Candida albicans ATCC 24433 assessed as concentration required to 50% growth inhibition using alamar blue staining after 18 to 72 hrs by microdilution method | 2010 | Bioorganic & medicinal chemistry, Nov-01, Volume: 18, Issue:21 | 1,3-Benzoxazole-4-carbonitrile as a novel antifungal scaffold of β-1,6-glucan synthesis inhibitors. |
| AID1700246 | Antifungal activity against Aspergillus flavus ATCC 204304 | 2020 | Bioorganic & medicinal chemistry letters, 12-15, Volume: 30, Issue:24 | Synthesis and biological screening of thiosemicarbazones of substituted 3-acetylcoumarins having d-glucose moiety. |
| AID1328364 | Antifungal activity against Cryptococcus neoformans H99 assessed as growth inhibition measured after 72 hrs by CLSI method | 2016 | Journal of natural products, 09-23, Volume: 79, Issue:9 | Synthesis of Natural Acylphloroglucinol-Based Antifungal Compounds against Cryptococcus Species. |
| AID1408105 | Antibacterial activity against Bacillus cereus UW 85 after 24 hrs by two-fold serial dilution method | 2018 | European journal of medicinal chemistry, Sep-05, Volume: 157 | Design, synthesis, antimicrobial, antiquorum-sensing and antitumor evaluation of new series of pyrazolopyridine derivatives. |
| AID1056014 | Antifungal activity against Candida albicans ATCC 2091 after 24 hrs by broth microdilution method | 2013 | European journal of medicinal chemistry, , Volume: 70 | Synthesis, biological evaluation and docking studies of 4-aryloxymethyl coumarins derived from substructures and degradation products of vancomycin. |
| AID1491263 | Inhibition of CYP51 in Candida albicans ATCC SC5314 assessed as lanosterol content at 2 ug/ml by GS-MS analysis relative to total sterols | 2017 | European journal of medicinal chemistry, Sep-08, Volume: 137 | Design, synthesis and evaluation of aromatic heterocyclic derivatives as potent antifungal agents. |
| AID1602363 | Antifungal activity against Cryptococcus neoformans H99 after 48 hrs by growth curve assay | 2019 | Journal of medicinal chemistry, 03-14, Volume: 62, Issue:5 | Discovery of Carboline Derivatives as Potent Antifungal Agents for the Treatment of Cryptococcal Meningitis. |
| AID244898 | In-vitro minimum inhibitory concentration against the growth of Aspergillus fumigatus | 2005 | Bioorganic & medicinal chemistry letters, Jul-01, Volume: 15, Issue:13 | Synthesis of (1,4)-naphthoquinono-[3,2-c]-1H-pyrazoles and their (1,4)-naphthohydroquinone derivatives as antifungal, antibacterial, and anticancer agents. |
| AID369385 | Antimicrobial activity against Geotrichum capitatum isolate | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | In vitro susceptibility to posaconazole of 1,903 yeast isolates recovered in France from 2003 to 2006 and tested by the method of the European committee on antimicrobial susceptibility testing. |
| AID386933 | Antifungal activity against Candida albicans ATCC 10453 after 48 hrs by broth microdilution technique | 2008 | European journal of medicinal chemistry, Oct, Volume: 43, Issue:10 | Carbodithioic acid esters of fluoxetine, a novel class of dual-function spermicides. |
| AID572692 | Binding affinity to Mycobacterium smegmatis ATCC 700084 CYP51 at pH7.5 | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Identification, characterization, and azole-binding properties of Mycobacterium smegmatis CYP164A2, a homolog of ML2088, the sole cytochrome P450 gene of Mycobacterium leprae. |
| AID1472846 | Inhibition of 14alpha-demethylase in Candida albicans ATCC 10231 assessed as ergosterol levels at 1.95 ug/mL by GC-MS analysis | 2018 | Journal of medicinal chemistry, 01-11, Volume: 61, Issue:1 | Alkylated Piperazines and Piperazine-Azole Hybrids as Antifungal Agents. |
| AID1592233 | Binding affinity to heme by UV-Visible spectroscopy | 2019 | Bioorganic & medicinal chemistry, 06-15, Volume: 27, Issue:12 | Design, synthesis and biological evaluation of amide-pyridine derivatives as novel dual-target (SE, CYP51) antifungal inhibitors. |
| AID293880 | Antifungal activity against fluconazole-resistant Candida albicans CMAH 0520 after 48 to 72 hrs by broth microdilution method | 2007 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 17, Issue:6 | Synthesis of pseudopeptides based L-tryptophan as a potential antimicrobial agent. |
| AID1904297 | Anti-cryptococcal activity against Cryptococcus assessed as inhibition of fungal growth incubated for 72 hrs by microdilution method | 2022 | Journal of medicinal chemistry, 05-12, Volume: 65, Issue:9 | Discovery of Novel Sertraline Derivatives as Potent Anti- |
| AID525404 | Antifungal activity against Candida glabrata isolate 4293 after 48 hrs by microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Posaconazole against Candida glabrata isolates with various susceptibilities to fluconazole. |
| AID464677 | Antifungal activity against Mucor fuscus after 48 to 72 hrs by broth micro dilution method | 2010 | European journal of medicinal chemistry, Mar, Volume: 45, Issue:3 | Synthesis and antimicrobial studies on novel sulfonamides containing 4-azidomethyl coumarin. |
| AID619170 | Antifungal activity against Candida parapsilosis 90018 by broth dilution method | 2011 | Journal of medicinal chemistry, Oct-13, Volume: 54, Issue:19 | High-throughput-screening-based identification and structure-activity relationship characterization defined (S)-2-(1-aminoisobutyl)-1-(3-chlorobenzyl)benzimidazole as a highly antimycotic agent nontoxic to cell lines. |
| AID754922 | Antifungal activity against Candida albicans ATCC 44859 assessed as growth inhibition after 24 to 48 hrs by microbroth dilution method | 2013 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 23, Issue:12 | Synthesis and antimycobacterial evaluation of N-substituted 5-chloropyrazine-2-carboxamides. |
| AID530735 | Antifungal activity against Candida albicans ATCC 60193 at 163.3 uM after 48 hrs by CLSI method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Potent in vitro antifungal activities of naturally occurring acetylenic acids. |
| AID1595045 | Antifungal activity against Candida glabrata assessed as reduction in fungal cell growth incubated for 48 hrs by broth microdilution method | 2019 | European journal of medicinal chemistry, May-15, Volume: 170 | Tetrazole hybrids and their antifungal activities. |
| AID1054670 | Cytotoxicity against african green monkey Vero cells at 10 ug/ml after 48 hrs by Neutral Red dye assay | 2013 | European journal of medicinal chemistry, , Volume: 70 | Structure-activity relationship (SAR) and preliminary mode of action studies of 3-substituted benzylthioquinolinium iodide as anti-opportunistic infection agents. |
| AID1726240 | Selectivity index, ratio of CC50 of human HepG2 cells to MIC of antifungal activity against Candida tropicalis ATCC 200956 | |||
| AID1549159 | Inhibition of CYP51 in azole-resistant Candida albicans 0304103 assessed as lanosterol level at 0.5 ug/ml after 24 hrs by GC-MS analysis (Rvb = 4.15%) | 2020 | Journal of medicinal chemistry, 05-28, Volume: 63, Issue:10 | Discovery of Novel Fungal Lanosterol 14α-Demethylase (CYP51)/Histone Deacetylase Dual Inhibitors to Treat Azole-Resistant Candidiasis. |
| AID279098 | Ratio of weight normalized daily dose in candidemia patient to MIC against Candida parapsilosis | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Association of fluconazole area under the concentration-time curve/MIC and dose/MIC ratios with mortality in nonneutropenic patients with candidemia. |
| AID424633 | Antimicrobial activity against azole-resistant Candida albicans isolate CA10 co-treated with calcineurin signaling inhibitor tacrolimus after 48 hrs by microdilution checkerboard technique | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | In vitro interactions between tacrolimus and azoles against Candida albicans determined by different methods. |
| AID48570 | Minimum concentration required to inhibit the growth of Candida albicans ATCC 64550 was determined | 2002 | Bioorganic & medicinal chemistry letters, Oct-07, Volume: 12, Issue:19 | Synthesis and evaluation of novel pyrrolidinyl sordaricin derivatives as antifungal agents. |
| AID655583 | Antifungal activity against Candida parapsilosis by microbroth dilution method | 2012 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 22, Issue:8 | New triazole derivatives as antifungal agents: synthesis via click reaction, in vitro evaluation and molecular docking studies. |
| AID613565 | Antifungal activity against Aspergillus fumigatus ATCC 96918 after 24 hrs by twofold serial dilution method | 2011 | European journal of medicinal chemistry, Sep, Volume: 46, Issue:9 | Synthesis of novel fluconazoliums and their evaluation for antibacterial and antifungal activities. |
| AID1413344 | Antifungal activity against Fusarium graminearum B4-5A strain D after 48 hrs by microdilution assay | 2018 | MedChemComm, Jun-01, Volume: 9, Issue:6 | Antifungal amphiphilic kanamycins: new life for an old drug. |
| AID1890289 | Cytotoxicity against mouse NIH/3T3 cells assessed as reduction in cell viability at 100 ug/ml incubated for 48 hrs by MTT assay (Rvb = 93.8 +/- 4.9 %) | 2022 | Bioorganic & medicinal chemistry letters, 05-01, Volume: 63 | Novel 2-aryl-4-aryloxyquinoline-based fungistatics for Mucor circinelloides. Biological evaluation of activity, QSAR and docking study. |
| AID420083 | Antifungal activity against Candida albicans CA-6 infected in CD1 mouse assessed as reduction of inflammatory foci in kidney at 10 mg/kg, ip pretreated 2 hrs before fungus-challenge and once daily for 6 days measured 7 days post-infection by periodic acid | 2009 | Bioorganic & medicinal chemistry, Jun-01, Volume: 17, Issue:11 | Bulky 1,4-benzoxazine derivatives with antifungal activity. |
| AID424653 | Antimicrobial activity against azole-resistant Candida albicans isolate CA10 assessed as growth at 2 ug/ml cotreated with 0.063 ug/ml calcineurin signaling inhibitor tacrolimus after 48 hrs by microdilution checkerboard technique relative to control | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | In vitro interactions between tacrolimus and azoles against Candida albicans determined by different methods. |
| AID49981 | Minimum concentration required to inhibit the growth of Candida glabrata ATCC 90030 was determined | 2002 | Bioorganic & medicinal chemistry letters, Oct-07, Volume: 12, Issue:19 | Synthesis and evaluation of novel pyrrolidinyl sordaricin derivatives as antifungal agents. |
| AID1877330 | Inhibition of CYP51 in Candida albicans SC3514 assessed as decrease in ergosterol biosynthesis by measuring unknown sterol 7 level at 0.25 ug/ml incubated for 16 hrs by GC-MS analysis relative to total sterols (Rvb=3.07%) | 2022 | European journal of medicinal chemistry, Jan-05, Volume: 227 | Broadening antifungal spectrum and improving metabolic stablity based on a scaffold strategy: Design, synthesis, and evaluation of novel 4-phenyl-4,5-dihydrooxazole derivatives as potent fungistatic and fungicidal reagents. |
| AID1738717 | Inhibition of CYP51 in azole-resistant Candida albicans ATCC SC531 assessed as ergosterol level at 0.5 ug/ml incubated for 16 hrs by LC-MS analysis relative to control | 2020 | European journal of medicinal chemistry, Jul-15, Volume: 198 | Design, synthesis, and biological evaluation of novel miconazole analogues containing selenium as potent antifungal agents. |
| AID519680 | Antimicrobial activity against Saccharomyces cerevisiae containing disruption in RAD18 gene by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Genomewide screening for genes associated with gliotoxin resistance and sensitivity in Saccharomyces cerevisiae. |
| AID1246769 | Selectivity index, ratio of IC50 for African green monkey Vero cells to MIC for Cryptococcus gattii ATCC 24065 | 2015 | European journal of medicinal chemistry, Sep-18, Volume: 102 | Thiazole compounds with activity against Cryptococcus gattii and Cryptococcus neoformans in vitro. |
| AID1903352 | Antifungal activity against Cryptococcus neoformans ATCC 32719 assessed as reduction in fungal growth incubated for 24 hrs by two fold broth dilution method | 2022 | European journal of medicinal chemistry, Apr-05, Volume: 233 | Design, synthesis, and biological evaluation of novel spiro[pyrrolidine-2,3'-quinolin]-2'-one derivatives as potential chitin synthase inhibitors and antifungal agents. |
| AID1451792 | Antifungal activity against Trichophyton rubrum after 7 days | 2017 | Journal of medicinal chemistry, 10-12, Volume: 60, Issue:19 | Novel Inhibitors of Staphyloxanthin Virulence Factor in Comparison with Linezolid and Vancomycin versus Methicillin-Resistant, Linezolid-Resistant, and Vancomycin-Intermediate Staphylococcus aureus Infections in Vivo. |
| AID554994 | Antifungal activity against Candida glabrata assessed as dose dependent percent susceptible isolates at 25 ug/disc by CLSI M44-A disk diffusion method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | In vitro activities of fluconazole and voriconazole against clinical isolates of Candida spp. determined by disk diffusion testing in Turin, Italy. |
| AID674385 | Antifungal activity against Aspergillus flavus MTCC 3306 at 0.5 mg/ml after 72 hrs by well plate method | 2012 | Bioorganic & medicinal chemistry letters, Jul-15, Volume: 22, Issue:14 | Synthesis of benzofuran based 1,3,5-substituted pyrazole derivatives: as a new class of potent antioxidants and antimicrobials--a novel accost to amend biocompatibility. |
| AID595006 | Ratio of MIC to MFC for Penicillium marneffei | 2011 | Bioorganic & medicinal chemistry letters, May-15, Volume: 21, Issue:10 | Thermal solvent-free synthesis of novel pyrazolyl chalcones and pyrazolines as potential antimicrobial agents. |
| AID1124797 | Antifungal activity against Candida albicans clinical isolate after 24 to 48 hrs by standard broth microdilution method | 2014 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 24, Issue:7 | Synthesis and evaluation of new diaryl ether and quinoline hybrids as potential antiplasmodial and antimicrobial agents. |
| AID1563960 | Antifungal activity against Aspergillus flavus ATCC 16870 assessed as reduction in fungal cell growth incubated for 48 hrs by two-fold serial dilution method | 2019 | European journal of medicinal chemistry, Oct-15, Volume: 180 | Design, synthesis and biological evaluation of novel 5-(piperazin-1-yl)quinolin-2(1H)-one derivatives as potential chitin synthase inhibitors and antifungal agents. |
| AID527139 | Antifungal activity against Candida albicans ATCC 10231 after 5 days microdilution technique | 2010 | Journal of natural products, Oct-22, Volume: 73, Issue:10 | Search for antifungal compounds from the wood of durable tropical trees. |
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| AID1359817 | Antifungal activity against Aspergillus flavus ATCC 16870 measured after 24 hrs | |||
| AID386921 | Antifungal activity against Candida albicans after 48 hrs by broth microdilution technique | 2008 | European journal of medicinal chemistry, Oct, Volume: 43, Issue:10 | Carbodithioic acid esters of fluoxetine, a novel class of dual-function spermicides. |
| AID1585640 | Antifungal activity against Candida parapsilosis ATCC 22019 cultured in YNB media after 72 hrs by broth microdilution method | 2019 | European journal of medicinal chemistry, Jan-15, Volume: 162 | Chemical preparation, biological evaluation and 3D-QSAR of ethoxysulfuron derivatives as novel antifungal agents targeting acetohydroxyacid synthase. |
| AID516260 | Antimicrobial activity against Cryptococcus gattii serotype B isolate NIH487 assessed as concentration required for heteroresistance | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Heteroresistance of Cryptococcus gattii to fluconazole. |
| AID386971 | Antimicrobial activity Fusarium oxysporum at 25 ug/mL after 48 hrs by agar diffusion technique | 2008 | European journal of medicinal chemistry, Oct, Volume: 43, Issue:10 | Synthesis and antimicrobial activity of some new heterocycles incorporating antipyrine moiety. |
| AID45326 | Evaluation of In vitro antifungal activity against Candida albicans 406 by broth macro dilution method | 1995 | Journal of medicinal chemistry, Sep-29, Volume: 38, Issue:20 | Synthesis and antifungal activity of new azole derivatives containing an N-acylmorpholine ring. |
| AID518176 | Antimicrobial activity against Cryptococcus gattii serotype B isolate B3939 assessed as heteroresistant isolates at 2 ug/ml | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Heteroresistance of Cryptococcus gattii to fluconazole. |
| AID665067 | Antifungal activity against Candida albicans after 24 hrs by serial dilution method | 2012 | European journal of medicinal chemistry, Jul, Volume: 53 | Design, synthesis and structure-activity relationships of new triazole derivatives containing N-substituted phenoxypropylamino side chains. |
| AID1465983 | Antifungal activity against Cryptococcus gattii NR-43208 after 68 hrs by broth dilution assay | 2017 | Bioorganic & medicinal chemistry, 06-01, Volume: 25, Issue:11 | Investigation of aryl isonitrile compounds with potent, broad-spectrum antifungal activity. |
| AID1334854 | Inhibition of Candida albicans SC5314 CYP51 assessed as ergosterol composition of total sterols at 8 ug/ml by GC-MS method (Rvb = 89.4 %) | 2017 | Bioorganic & medicinal chemistry, 01-15, Volume: 25, Issue:2 | Discovery of biphenyl imidazole derivatives as potent antifungal agents: Design, synthesis, and structure-activity relationship studies. |
| AID1886036 | Synergistic antifungal activity against Candida parapsilosis ATCC22019 assessed as fractional inhibitory concentration index incubated for 48 hrs in presence of P163-0892 by broth microdilution method | |||
| AID395840 | Antimicrobial activity against Candida parapsilosis after 48 hrs by standard microbroth dilution assay | 2009 | European journal of medicinal chemistry, Jan, Volume: 44, Issue:1 | Tetrahydronaphthyl azole oxime ethers: the conformationally rigid analogues of oxiconazole as antibacterials. |
| AID572702 | Binding affinity to Mycobacterium avium CYP51 | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Identification, characterization, and azole-binding properties of Mycobacterium smegmatis CYP164A2, a homolog of ML2088, the sole cytochrome P450 gene of Mycobacterium leprae. |
| AID1392820 | Inhibition of Cyp51 in Candida albicans ATCC SC5314 assessed as obtusifoliol content at 2 ug/ml after 16 hrs by GC-MS analysis (Rvb = 0.6%) | 2018 | Bioorganic & medicinal chemistry, 07-23, Volume: 26, Issue:12 | Design, synthesis and evaluation of benzoheterocycle analogues as potent antifungal agents targeting CYP51. |
| AID737323 | Antimicrobial activity against Aspergillus oryzae MTCC 3567 at 500 ug/ml after 72 hrs by cup plate method | 2013 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 23, Issue:7 | Synthesis of novel 2-amino-4-(5'-substituted 2'-phenyl-1H-indol-3'-yl)-6-aryl-4H-pyran-3-carbonitrile derivatives as antimicrobial and antioxidant agents. |
| AID48800 | Minimal inhibitory effect against the Candida tropicalis (2808E). | 2002 | Bioorganic & medicinal chemistry letters, Jul-08, Volume: 12, Issue:13 | Antifungal Sordarins. Part 4: synthesis and structure--activity relationships of 3',4'-fused alkyl-tetrahydrofuran derivatives. |
| AID1413332 | Antifungal activity against sensitive Candida albicans MYA-2876 | 2018 | MedChemComm, Jun-01, Volume: 9, Issue:6 | Antifungal amphiphilic kanamycins: new life for an old drug. |
| AID725883 | Antifungal activity against fluconazole-resistant Candida albicans DSY292 after 24 hrs by spectrofluorometric analysis | 2013 | ACS medicinal chemistry letters, Feb-14, Volume: 4, Issue:2 | Discovery of a novel broad-spectrum antifungal agent derived from albaconazole. |
| AID582799 | Antifungal activity against Candida albicans isolate 12 harboring ERG3 W332R mutant gene by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | Identification and characterization of four azole-resistant erg3 mutants of Candida albicans. |
| AID1624195 | Antibiofilm activity against 48 hrs old pre-formed biofilms of Candida albicans ATCC 10231 at 128 ug/ml after 24 hrs by MTS assay relative to control | 2019 | Bioorganic & medicinal chemistry letters, 03-01, Volume: 29, Issue:5 | Benzimidazole tethered pyrrolo[3,4-b]quinoline with broad-spectrum activity against fungal pathogens. |
| AID1759449 | Cytotoxicity against human HEK293 cells assessed as cell survival at 0.5 times MIC incubated for 24 hrs by MTT assay | 2021 | Bioorganic & medicinal chemistry letters, 06-01, Volume: 41 | Inhibitory effects and mechanism of antifungal action of the natural cyclic depsipeptide, aureobasidin A against Cryptococcus neoformans. |
| AID1546133 | Antibacterial activity against Micrococcus luteus ATCC 4698 after 24 hrs by two-fold broth serial dilution method | 2019 | European journal of medicinal chemistry, Dec-15, Volume: 184 | Current scenario of tetrazole hybrids for antibacterial activity. |
| AID555581 | Antimicrobial activity against Candida metapsilosis by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Activity profile in vitro of micafungin against Spanish clinical isolates of common and emerging species of yeasts and molds. |
| AID392366 | Antifungal activity against Absidia corymbifera 272 after 24 hrs by broth microdilution method | 2009 | Bioorganic & medicinal chemistry letters, Jan-15, Volume: 19, Issue:2 | Salicylanilide esters of N-protected amino acids as novel antimicrobial agents. |
| AID1138327 | Antimicrobial activity against Candida albicans SC5314 after 24 hrs by serial dilution method | 2014 | Journal of medicinal chemistry, May-08, Volume: 57, Issue:9 | Design, synthesis, and structure-activity relationship studies of novel fused heterocycles-linked triazoles with good activity and water solubility. |
| AID1165098 | Binding affinity to Trypanosoma cruzi CYP51 | 2014 | European journal of medicinal chemistry, Nov-24, Volume: 87 | Novel nitro(triazole/imidazole)-based heteroarylamides/sulfonamides as potential antitrypanosomal agents. |
| AID257328 | Antifungal activity against Candida albicans | 2005 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 15, Issue:24 | Synthesis and antimicrobial activity of 5-hydroxymethyl- 8-methyl-2-(N-arylimino)-pyrano[2,3-c]pyridine-3-(N-aryl)-carboxamides. |
| AID542088 | Antifungal activity against Candida tropicalis TIMM0313 after 24 hrs by microdilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Discovery of a small-molecule inhibitor of {beta}-1,6-glucan synthesis. |
| AID1598044 | Antifungal activity against Microsporum gypseum after 24 hrs | 2019 | European journal of medicinal chemistry, May-15, Volume: 170 | Current advances of triazole alcohols derived from fluconazole: Design, in vitro and in silico studies. |
| AID1898161 | Antifungal activity against Candida albicans 162 | |||
| AID1079934 | Highest frequency of acute liver toxicity observed during clinical trials, expressed as a percentage. [column '% AIGUE' in source] | |||
| AID285872 | Antimicrobial susceptibility of Pichia anomala from nosocomial fungemia patient assessed as percent susceptible isolates at 8 ug/ml by EUCAST method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Antifungal drug susceptibility profile of Pichia anomala isolates from patients presenting with nosocomial fungemia. |
| AID547605 | Antifungal activity against Candida glabrata isolate Cg18R with CgPDR1 L344S mutant | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | Microarray and molecular analyses of the azole resistance mechanism in Candida glabrata oropharyngeal isolates. |
| AID519285 | Antifungal activity against Candida parapsilosis ATCC 22019 by CLSI M27-A2 microdilution method | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | Reliability of the WIDERYST susceptibility testing system for detection of in vitro antifungal resistance in yeasts. |
| AID1911613 | Toxicity against Galleria mellonella larva infected with Candida albicans SC5314 assessed as increase in survival rate at 8 mg/kg measured for 14 days | 2022 | Journal of medicinal chemistry, 06-09, Volume: 65, Issue:11 | Development of Lipo-γ-AA Peptides as Potent Antifungal Agents. |
| AID1758043 | Inhibition of CYP51 in Candida albicans ATCC SC5314 assessed as Eburicol level at 0.5 ug/ml after 16 hrs by GC-MS analysis (Rvb = 0%) | 2021 | European journal of medicinal chemistry, Apr-15, Volume: 216 | Lead optimization generates selenium-containing miconazole CYP51 inhibitors with improved pharmacological profile for the treatment of fungal infections. |
| AID622964 | Antifungal activity against Candida parapsilosis ATCC 22019 after 48 hrs by microdilution method | 2011 | Bioorganic & medicinal chemistry letters, Oct-15, Volume: 21, Issue:20 | Synthesis and biological activity of desmethoxy analogues of coruscanone A. |
| AID1495961 | Antifungal activity against Trichophyton mentagrophytes after 72 hrs by broth microdilution method | 2018 | Bioorganic & medicinal chemistry, 07-23, Volume: 26, Issue:12 | Efficiency of newly prepared thiazole derivatives against some cutaneous fungi. |
| AID1180300 | Fungicidal activity against Candida albicans NCIM-3471 after 48 to 72 hrs by two fold serial macrodilution technique | 2014 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 24, Issue:15 | One pot three components microwave assisted and conventional synthesis of new 3-(4-chloro-2-hydroxyphenyl)-2-(substituted) thiazolidin-4-one as antimicrobial agents. |
| AID1154817 | Antifungal activity against Candida glabrata 537 after 24 hrs by serial dilution method | 2014 | ACS medicinal chemistry letters, May-08, Volume: 5, Issue:5 | Novel carboline derivatives as potent antifungal lead compounds: design, synthesis, and biological evaluation. |
| AID45324 | Evaluation of In vitro antifungal activity against Candida albicans 2.01 by broth macro dilution method | 1995 | Journal of medicinal chemistry, Sep-29, Volume: 38, Issue:20 | Synthesis and antifungal activity of new azole derivatives containing an N-acylmorpholine ring. |
| AID584402 | Antifungal activity against 88 days cultured Candida glabrata isolated from HSCT recipient with acute or chronic GVHD mouth receiving antifungal therapy for 75 days after 33 days of prophylaxis by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Impact of antifungal prophylaxis on colonization and azole susceptibility of Candida species. |
| AID1392832 | Inhibition of Cyp51 in Candida albicans ATCC SC5314 assessed as 4,4-dimethyl zymosterol content at 8 ug/ml after 16 hrs by GC-MS analysis relative to control | 2018 | Bioorganic & medicinal chemistry, 07-23, Volume: 26, Issue:12 | Design, synthesis and evaluation of benzoheterocycle analogues as potent antifungal agents targeting CYP51. |
| AID1689819 | Antifungal activity against fluconazole-resistant Candida krusei CAKR7 assessed as reduction in microbial growth after 24 hrs by resazurin staining based spectrofluorometric method | 2020 | European journal of medicinal chemistry, Mar-01, Volume: 189 | New azole antifungals with a fused triazinone scaffold. |
| AID1063947 | Antifungal activity against Aspergillus fumigatus 231 after 48 hrs by broth microdilution method | 2014 | Bioorganic & medicinal chemistry, Jan-15, Volume: 22, Issue:2 | Salicylanilide diethyl phosphates: synthesis, antimicrobial activity and cytotoxicity. |
| AID1391393 | Antifungal activity against Candida parapsilosis ATCC 22019 after 24 hrs by two fold serial dilution method | 2018 | Bioorganic & medicinal chemistry letters, 05-15, Volume: 28, Issue:9 | Novel purine benzimidazoles as antimicrobial agents by regulating ROS generation and targeting clinically resistant Staphylococcus aureus DNA groove. |
| AID1495960 | Antifungal activity against Microsporum gypseum after 72 hrs by broth microdilution method | 2018 | Bioorganic & medicinal chemistry, 07-23, Volume: 26, Issue:12 | Efficiency of newly prepared thiazole derivatives against some cutaneous fungi. |
| AID515009 | Antifungal activity against Candida albicans Y0109 after 24 hrs by micro-broth dilution method | 2010 | European journal of medicinal chemistry, Oct, Volume: 45, Issue:10 | Synthesis and antifungal evaluation of novel triazole derivatives as inhibitors of cytochrome P450 14alpha-demethylase. |
| AID1295980 | Antimicrobial activity against Saccharomyces cerevisiae BY4741 after 24 hrs by two fold serial dilution method | 2016 | Journal of natural products, Feb-26, Volume: 79, Issue:2 | Antifungal Quinoline Alkaloids from Waltheria indica. |
| AID1408108 | Antifungal activity against Candida albicans after 48 hrs by two-fold serial dilution method | 2018 | European journal of medicinal chemistry, Sep-05, Volume: 157 | Design, synthesis, antimicrobial, antiquorum-sensing and antitumor evaluation of new series of pyrazolopyridine derivatives. |
| AID1904359 | Antifungal activity against Cryptococcus neoformans CGMCC 2.3161 assessed as fungal growth inhibition by CLSI based serial microbroth dilution method | 2022 | European journal of medicinal chemistry, Apr-05, Volume: 233 | Design, synthesis, and evaluation of novel 3-thiophene derivatives as potent fungistatic and fungicidal reagents based on a conformational restriction strategy. |
| AID1624174 | Antifungal activity against Candida albicans NR-29438 after 24 hrs by microbroth dilution method | 2019 | Bioorganic & medicinal chemistry letters, 03-01, Volume: 29, Issue:5 | Benzimidazole tethered pyrrolo[3,4-b]quinoline with broad-spectrum activity against fungal pathogens. |
| AID1905342 | Invivo antifungal activity against azole resistant Candida albicans 904 infected in Sprague-Dawley rat assessed as reduction in kidney fungal burden at 1 mg/kg, ip administered for 5 days, qd | 2022 | Journal of medicinal chemistry, 04-14, Volume: 65, Issue:7 | Species-Selective Targeting of Fungal Hsp90: Design, Synthesis, and Evaluation of Novel 4,5-Diarylisoxazole Derivatives for the Combination Treatment of Azole-Resistant Candidiasis. |
| AID293378 | Antifungal activity against Candida albicans after 24 hrs by microbroth dilution method | 2007 | European journal of medicinal chemistry, Aug, Volume: 42, Issue:8 | Synthesis and evaluation of novel 1-(1H-1,2,4-triazol-1-yl)-2-(2,4-difluorophenyl)-3-[(4-substitutedphenyl)-piperazin-1-yl]-propan-2-ols as antifungal agents. |
| AID563612 | Effect on sterol composition in Candida albicans isolate 14 expressing wild type erg11 and erg5 assessed as 14 -Methylergosta-8,24(28)-dien-3beta,6alpha-diol level after 2 hrs by gas chromatography | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | A clinical isolate of Candida albicans with mutations in ERG11 (encoding sterol 14alpha-demethylase) and ERG5 (encoding C22 desaturase) is cross resistant to azoles and amphotericin B. |
| AID747357 | Antifungal activity against Aspergillus flavus by NCCLS method | 2013 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 23, Issue:11 | Synthesis and biological evaluation of a class of quinolone triazoles as potential antimicrobial agents and their interactions with calf thymus DNA. |
| AID1320774 | Antifungal activity against Fusarium oxysporum MF5 assessed as radial growth inhibition at 32 ug/ml after 5 to 7 days relative to control | 2016 | Bioorganic & medicinal chemistry, 11-15, Volume: 24, Issue:22 | Synthesis of novel tetrazole derivatives and evaluation of their antifungal activity. |
| AID323068 | Antifungal activity against Cryptococcus neoformans IM 972724 by micro-broth dilution method | 2008 | Bioorganic & medicinal chemistry, Jan-15, Volume: 16, Issue:2 | Antifungal and cytotoxic activities of some N-substituted aniline derivatives bearing a hetaryl fragment. |
| AID1864936 | Induction of apoptosis in Candida albicans ATCC SC5314 assessed as mid apoptotic cells incuabted for 24 hrs by V-FITC/PI staining based flow cytometry analysis (Rvb = 1.09%) | |||
| AID1877833 | Antifungal activity against Candida albicans CA800 by microdilution method | 2022 | Bioorganic & medicinal chemistry letters, 02-15, Volume: 58 | Synthesis and antifungal evaluation of phenol-derived bis(indolyl)methanes combined with FLC against Candida albicans. |
| AID1861429 | Antifungal activity against Candida albicans assessed as filamentous long hyphae in Spider medium by scanning electron microscopy | 2022 | Bioorganic & medicinal chemistry letters, 09-01, Volume: 71 | Discovery of novel indole and indoline derivatives against Candida albicans as potent antifungal agents. |
| AID1885955 | Antifungal activity against Cryptococcus gattii E566 assessed as fungal growth inhibition incubated for 72 hrs by broth microdilution method | |||
| AID1918341 | Antifungal activity against fluconazole-resistant Candida albicans 904 assessed as inhibition of fungal growth measured after 72 hrs by CLSI based liquid medium dilution method | 2022 | Journal of medicinal chemistry, 11-10, Volume: 65, Issue:21 | Novel Aryl Alkamidazole Derivatives as Multifunctional Antifungal Inhibitors: Design, Synthesis, and Biological Evaluation. |
| AID1337065 | Antifungal activity against fluconazole-resistant Candida albicans clinical isolate 33 | 2017 | ACS medicinal chemistry letters, Feb-09, Volume: 8, Issue:2 | Potent Antifungal Synergy of Phthalazinone and Isoquinolones with Azoles Against |
| AID1125785 | Antibacterial activity against Pseudomonas aeruginosa MTCC 4727 assessed as diameter of growth inhibition zone at 10 ug/ml after 20 hrs by agar disc diffusion method | 2014 | European journal of medicinal chemistry, Apr-22, Volume: 77 | New polyfunctional imidazo[4,5-C]pyridine motifs: synthesis, crystal studies, docking studies and antimicrobial evaluation. |
| AID581890 | Antifungal activity against Candida albicans isolated from HSCT recipient 462 with acute or chronic GVHD mouth after 112 days prophylaxis by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Impact of antifungal prophylaxis on colonization and azole susceptibility of Candida species. |
| AID444058 | Volume of distribution at steady state in human | 2010 | Journal of medicinal chemistry, Feb-11, Volume: 53, Issue:3 | Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. |
| AID1419529 | Effect on sterol composition in Candida albicans ATCC 64124 assessed as eburicol level at 0.125 ug/mL incubated for 10 mins by LC-MS analysis (Rvb = 6.28%) | 2017 | European journal of medicinal chemistry, Jun-16, Volume: 133 | Novel alkylated azoles as potent antifungals. |
| AID545330 | Antimicrobial activity against Candida albicans isolate C after 24 hrs by microdilution method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Breakthrough Aspergillus fumigatus and Candida albicans double infection during caspofungin treatment: laboratory characteristics and implication for susceptibility testing. |
| AID582237 | Antifungal activity against Candida glabrata isolated from neutropenic subjects with AML or MDS receiving posaconazole assessed as maximum MIC by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Impact of antifungal prophylaxis on colonization and azole susceptibility of Candida species. |
| AID419074 | Antifungal activity against Candida tropicalis ATCC 750 | 2009 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 19, Issue:7 | Amide analogs of antifungal dioxane-triazole derivatives: synthesis and in vitro activities. |
| AID478784 | Antifungal activity against Candida krusei ATCC 6258 after 18 hrs by broth microdilution assay | 2010 | European journal of medicinal chemistry, May, Volume: 45, Issue:5 | Synthesis, spectroscopic and biological studies on the new symmetric Schiff base derived from 2,6-diformyl-4-methylphenol with N-aminopyrimidine. |
| AID48573 | Minimum concentration required to inhibit the growth of Candida albicans SANK51486 was determined in the presence of horse serum (20%); NT means not tested | 2002 | Bioorganic & medicinal chemistry letters, Oct-07, Volume: 12, Issue:19 | Synthesis and evaluation of novel pyrrolidinyl sordaricin derivatives as antifungal agents. |
| AID1506723 | Antibacterial activity against Bacillus cereus MTCC 430 by agar dilution method | 2017 | MedChemComm, Mar-01, Volume: 8, Issue:3 | Design, synthesis, molecular-docking and antimycobacterial evaluation of some novel 1,2,3-triazolyl xanthenones. |
| AID1759455 | Induction of morphological changes in Cryptococcus neoformans PFCC 93-589 assessed as disintegration and loosening of cell membrane at 4 ug/ml after 48 hrs by TEM analysis | 2021 | Bioorganic & medicinal chemistry letters, 06-01, Volume: 41 | Inhibitory effects and mechanism of antifungal action of the natural cyclic depsipeptide, aureobasidin A against Cryptococcus neoformans. |
| AID666849 | Antifungal activity against Penicillium sp. at 6.25 ug/ml after 72 hrs by well plate method | 2012 | European journal of medicinal chemistry, Aug, Volume: 54 | Synthesis, characterization and antimicrobial studies of some new quinoline incorporated benzimidazole derivatives. |
| AID1689221 | Antifungal activity against Cryptococcus neoformans NR41298 assessed as reduction in fungal growth incubated for 48 hrs by CLSI based broth microdilution method | 2020 | European journal of medicinal chemistry, Mar-01, Volume: 189 | Oxadiazolylthiazoles as novel and selective antifungal agents. |
| AID1369461 | Fungicidal activity against Candida albicans isolated from alveolar fluid after 96 hrs | 2018 | Journal of medicinal chemistry, 05-10, Volume: 61, Issue:9 | Combating Drug-Resistant Fungi with Novel Imperfectly Amphipathic Palindromic Peptides. |
| AID575751 | Antimicrobial activity against sterol 14-alpha demethylase isoenzyme B-deficient Aspergillus fumigatus CEA10 | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10 | Expression, purification, and characterization of Aspergillus fumigatus sterol 14-alpha demethylase (CYP51) isoenzymes A and B. |
| AID1783779 | Antifungal activity against fluconazole and itraconazole resistant Candida albicans 17# assessed as inhibition of fungal growth by NCCLS protocol based method | 2021 | European journal of medicinal chemistry, Nov-15, Volume: 224 | Improving the metabolic stability of antifungal compounds based on a scaffold hopping strategy: Design, synthesis, and structure-activity relationship studies of dihydrooxazole derivatives. |
| AID294848 | Antifungal activity against Candida albicans ATCC Y0109 after 24 hrs by micro-broth dilution method | 2007 | European journal of medicinal chemistry, Sep, Volume: 42, Issue:9 | Synthesis of novel triazole derivatives as inhibitors of cytochrome P450 14alpha-demethylase (CYP51). |
| AID462236 | Antifungal activity against Candida albicans SA40 infected in Wistar rat estrogen-dependent fungal vaginitis model assessed as fungal burden at 10 ug administered intravaginally 48 hrs after fungal infection measured on day 28 after infection | 2010 | Journal of medicinal chemistry, Mar-25, Volume: 53, Issue:6 | Identification of inhibitors of drug-resistant Candida albicans strains from a library of bicyclic peptidomimetic compounds. |
| AID584383 | Ratio of CDR2 gene expression in Candida glabrata isolated from patient 491 receiving antifungal drug to CDR2 gene expression in Candida glabrata isolated from patient 491 by RT-PCR analysis | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Impact of antifungal prophylaxis on colonization and azole susceptibility of Candida species. |
| AID1904258 | Antifungal activity against Candida albicans 0304103 assessed as inhibition of fungal growth incubated for 48 hrs by microdilution method | 2022 | Journal of medicinal chemistry, 05-12, Volume: 65, Issue:9 | Discovery of Novel Sertraline Derivatives as Potent Anti- |
| AID1493833 | Antifungal activity against Microsporum gypseum Cmccfmza after 24 hrs by spectrophotometric analysis | 2018 | European journal of medicinal chemistry, Jan-01, Volume: 143 | Discovery of simplified sampangine derivatives as novel fungal biofilm inhibitors. |
| AID584599 | Antifungal activity against 6 days cultured Candida krusei isolated from neutropenic subject with AML or MDS pharynx receiving antifungal therapy for 19 days after 6 days of prophylaxis by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Impact of antifungal prophylaxis on colonization and azole susceptibility of Candida species. |
| AID1886046 | Synergistic antifungal activity against Cryptococcus neoformans clinical isolate BJ3 assessed as fractional inhibitory concentration index incubated for 72 hrs in presence of P163-0892 by broth microdilution method | |||
| AID561425 | Antifungal activity against Candida lusitaniae CL38-5 expressing FCY2 gene by microdilution method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Nonsense and missense mutations in FCY2 and FCY1 genes are responsible for flucytosine resistance and flucytosine-fluconazole cross-resistance in clinical isolates of Candida lusitaniae. |
| AID1418528 | Antifungal activity against Candida albicans cpcc 400616 after 2 to 7 days by broth microdilution method | 2018 | Bioorganic & medicinal chemistry letters, 12-01, Volume: 28, Issue:22 | Design, synthesis, and biological evaluation of 4-chloro-2H-thiochromenes featuring nitrogen-containing side chains as potent antifungal agents. |
| AID1674373 | Fraction unbound in human | 2020 | Journal of medicinal chemistry, 11-12, Volume: 63, Issue:21 | Integrating the Impact of Lipophilicity on Potency and Pharmacokinetic Parameters Enables the Use of Diverse Chemical Space during Small Molecule Drug Optimization. |
| AID45515 | Inhibitory effect on Candida albicans wild type YEM14 Strain | 2004 | Journal of medicinal chemistry, Jan-01, Volume: 47, Issue:1 | Folate-synthesizing enzyme system as target for development of inhibitors and inhibitor combinations against Candida albicans-synthesis and biological activity of new 2,4-diaminopyrimidines and 4'-substituted 4-aminodiphenyl sulfones. |
| AID323070 | Antifungal activity against Cryptococcus neoformans IM 983036 by micro-broth dilution method | 2008 | Bioorganic & medicinal chemistry, Jan-15, Volume: 16, Issue:2 | Antifungal and cytotoxic activities of some N-substituted aniline derivatives bearing a hetaryl fragment. |
| AID1311357 | Antifungal activity against Aspergillus niger by broth dilution method | 2016 | Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15 | Synthesis and antimicrobial evaluation of novel ethyl 2-(2-(4-substituted)acetamido)-4-subtituted-thiazole-5-carboxylate derivatives. |
| AID1743167 | Antifungal activity against Trichophyton gypseum | 2020 | European journal of medicinal chemistry, Dec-15, Volume: 208 | Multiple biological active 4-aminopyrazoles containing trifluoromethyl and their 4-nitroso-precursors: Synthesis and evaluation. |
| AID758161 | Antifungal activity against Candida albicans after 24 hrs by twofold broth dilution method | 2013 | Bioorganic & medicinal chemistry, Jul-15, Volume: 21, Issue:14 | Synthesis and bioactive evaluation of novel hybrids of metronidazole and berberine as new type of antimicrobial agents and their transportation behavior by human serum albumin. |
| AID565550 | Antifungal activity against Rhizopus microsporus IHEM 13311 by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Correlation of in vitro activity, serum levels, and in vivo efficacy of posaconazole against Rhizopus microsporus in a murine disseminated infection. |
| AID1473740 | Inhibition of human MRP3 overexpressed in Sf9 insect cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and GSH measured after 10 mins by membrane vesicle transport assay | 2013 | Toxicological sciences : an official journal of the Society of Toxicology, Nov, Volume: 136, Issue:1 | A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. |
| AID1850957 | Antifungal activity against Aspergillus fumigatus assessed as inhibition of fungal growth | 2022 | Bioorganic & medicinal chemistry letters, 10-01, Volume: 73 | Pyrimidine-conjugated fluoroquinolones as new potential broad-spectrum antibacterial agents. |
| AID583013 | Ratio of MIC for Saccharomyces cerevisiae YUG37 transformed with plasmid carrying cyp51A gene with compound-regulatable promoter to MIC for Saccharomyces cerevisiae YUG37 transformed with plasmid carrying cyp51B gene with compound-regulatable promoter | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | Complementation of a Saccharomyces cerevisiae ERG11/CYP51 (sterol 14α-demethylase) doxycycline-regulated mutant and screening of the azole sensitivity of Aspergillus fumigatus isoenzymes CYP51A and CYP51B. |
| AID772332 | Antifungal activity against wild type Candida tropicalis after 24 hrs by visually and spectrophotometric analysis | 2013 | ACS medicinal chemistry letters, Sep-12, Volume: 4, Issue:9 | Novel Macrocyclic Amidinoureas: Potent Non-Azole Antifungals Active against Wild-Type and Resistant Candida Species. |
| AID1904286 | Inhibition of Cryptococcus neoformans H99 delta5,6-desaturase assessed as upregulation of ERG2 gene expression at 2 ug/ml incubated for 24 hrs by RT-PCR analysis | 2022 | Journal of medicinal chemistry, 05-12, Volume: 65, Issue:9 | Discovery of Novel Sertraline Derivatives as Potent Anti- |
| AID518894 | Antimicrobial activity against Cryptococcus gattii serotype C isolate H0058-1-818 assessed as heteroresistant isolates at 32 ug/ml | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Heteroresistance of Cryptococcus gattii to fluconazole. |
| AID682603 | Antifungal activity against Cryptococcus neoformans after 72 hrs by broth microdilution method | 2012 | European journal of medicinal chemistry, Oct, Volume: 56 | Micelles catalyzed chemo- and regio-selective one pot and one step synthesis of 2,3,5,6-tetrakis(alkyl and arylsulfanyl)-1,4-benzoquinones and 2,5-diaminosubstituted-1,4-benzoquinones "In-Water" and their biological evaluation as antibacterial and antifun |
| AID372253 | Fungicidal activity against Candida albicans SSK21 assessed as reduction in cell viability at MIC after 24 hrs | 2007 | Antimicrobial agents and chemotherapy, Oct, Volume: 51, Issue:10 | The Ssk1p response regulator and Chk1p histidine kinase mutants of Candida albicans are hypersensitive to fluconazole and voriconazole. |
| AID1128929 | Antifungal activity against Aspergillus fumigatus assessed as total growth inhibition by micro-broth dilution method | 2014 | European journal of medicinal chemistry, Apr-09, Volume: 76 | Imidazolylchromanones containing non-benzylic oxime ethers: synthesis and molecular modeling study of new azole antifungals selective against Cryptococcus gattii. |
| AID1898191 | Inhibition of CYP51 in Candida albicans SC5314 assessed as lanosterol level at 0.5 ug/ml measured after 12 hrs by GC-MS analysis (Rvb = 2.18%) | |||
| AID419073 | Antifungal activity against Candida glabrata ATCC 90030 | 2009 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 19, Issue:7 | Amide analogs of antifungal dioxane-triazole derivatives: synthesis and in vitro activities. |
| AID518179 | Antimicrobial activity against Cryptococcus gattii serotype B isolate NIH189 assessed as heteroresistant isolates at 2 ug/ml | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Heteroresistance of Cryptococcus gattii to fluconazole. |
| AID1265641 | Antifungal activity against Candida glabrata clinical isolate after 24 hrs by sabouraud dextrose broth based microdilution method | 2016 | European journal of medicinal chemistry, Jan-01, Volume: 107 | Anti-Candida activity and cytotoxicity of a large library of new N-substituted-1,3-thiazolidin-4-one derivatives. |
| AID1419565 | Selectivity index, ratio of EC50 for toxicity in human A549 cells to MIC50 for antifungal activity against Candida albicans ATCC 10231 | 2017 | European journal of medicinal chemistry, Jun-16, Volume: 133 | Novel alkylated azoles as potent antifungals. |
| AID144063 | In vitro inhibitory activity against human Nmt (HsNmt) using substrate peptide GNAASAR-R-NH2 (0.5 uM) and myristoyl-CoA (0.5 uM); Not tested | 2003 | Bioorganic & medicinal chemistry letters, Jan-06, Volume: 13, Issue:1 | Design and synthesis of novel benzofurans as a new class of antifungal agents targeting fungal N-myristoyltransferase. Part 3. |
| AID744034 | Antifungal activity against Candida albicans ATCC 10231 assessed as growth inhibition at 1000 ug/mL after 72 hrs by disk diffusion method | 2013 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 23, Issue:8 | Synthesis and antimicrobial activity of polyhalo isophthalonitrile derivatives. |
| AID741613 | Antifungal activity against Cryptococcus neoformans KCCM 50564 after 1 day by two fold broth dilution method | 2013 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 23, Issue:7 | Synthesis and antifungal evaluation of 7-arylamino-5,8-dioxo-5,8-dihydroisoquinoline-4-carboxylates. |
| AID42858 | Inhibition of Candida albicans ATCC 90028 for 48 hours in vitro. | 2001 | Journal of medicinal chemistry, Aug-16, Volume: 44, Issue:17 | 3-Phenyl-5-acyloxymethyl-2H,5H-furan-2-ones: synthesis and biological activity of a novel group of potential antifungal drugs. |
| AID1628381 | Antimicrobial activity against Eberthella typhosa ATCC 14028 incubated for 24 hrs by NCCLS protocol based method | 2016 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 26, Issue:12 | Discovery of novel berberine imidazoles as safe antimicrobial agents by down regulating ROS generation. |
| AID1890285 | Antifungal activity against Aspergillus niger clinical isolate 1 assessed as reduction in fungal growth by broth dilution method | 2022 | Bioorganic & medicinal chemistry letters, 05-01, Volume: 63 | Novel 2-aryl-4-aryloxyquinoline-based fungistatics for Mucor circinelloides. Biological evaluation of activity, QSAR and docking study. |
| AID245573 | In vitro concentration required to inhibit 80% growth of Saccharomyces cerevisiae strain YEM172 (CDR1 over-expressed) after 48 h | 2004 | Bioorganic & medicinal chemistry letters, Oct-18, Volume: 14, Issue:20 | Quinazolinone fungal efflux pump inhibitors. Part 2: In vitro structure-activity relationships of (N-methyl-piperazinyl)-containing derivatives. |
| AID365073 | Antifungal activity against Aspergillus niger ATCC 16404 after 3 days by broth macrodilution method | 2008 | Bioorganic & medicinal chemistry, Sep-01, Volume: 16, Issue:17 | Antifungal activity of synthetic di(hetero)arylamines based on the benzo[b]thiophene moiety. |
| AID626345 | Antifungal activity against Chrysosporium keratinophilum MTCC 2827 at 0.5 mg/mL after 72 hrs by by agar-well diffusion method | 2011 | European journal of medicinal chemistry, Nov, Volume: 46, Issue:11 | Hantzsch reaction: synthesis and characterization of some new 1,4-dihydropyridine derivatives as potent antimicrobial and antioxidant agents. |
| AID1481573 | Antifungal activity against Candida albicans ATCC 76615 after 24 hrs by two-fold serial dilution assay | 2017 | Bioorganic & medicinal chemistry letters, 04-15, Volume: 27, Issue:8 | Novel benzimidazolyl tetrahydroprotoberberines: Design, synthesis, antimicrobial evaluation and multi-targeting exploration. |
| AID584597 | Antifungal activity against 1 day cultured Candida krusei isolated from neutropenic subject with AML or MDS pharynx receiving antifungal therapy for 19 days after 6 days of prophylaxis by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Impact of antifungal prophylaxis on colonization and azole susceptibility of Candida species. |
| AID625771 | Antifungal activity against Candida parapsilosis ATCC 22019 after 24 hrs by serial dilution method | 2011 | European journal of medicinal chemistry, Nov, Volume: 46, Issue:11 | Design and synthesis of novel triazole antifungal derivatives by structure-based bioisosterism. |
| AID287820 | Antifungal activity against Candida albicans ATCC 44859 after 48 hrs | 2007 | Bioorganic & medicinal chemistry, Apr-15, Volume: 15, Issue:8 | Hybrid molecules of estrone: new compounds with potential antibacterial, antifungal, and antiproliferative activities. |
| AID1413576 | Antifungal activity against Candida glabrata ATCC 0001 by broth microdilution method | |||
| AID1059365 | Antifungal activity against Candida tropicalis after 20 hrs by agar dilution method | 2013 | European journal of medicinal chemistry, , Volume: 70 | Designing and synthesis of novel antimicrobial heterocyclic analogs of fatty acids. |
| AID1335845 | Antifungal activity against Candida utilis after 24 hrs by two fold serial dilution method | 2016 | European journal of medicinal chemistry, Nov-29, Volume: 124 | Multi-targeting exploration of new 2-aminothiazolyl quinolones: Synthesis, antimicrobial evaluation, interaction with DNA, combination with topoisomerase IV and penetrability into cells. |
| AID1456583 | Antifungal activity against Microsporum gypseum isolate cmccftla by micro-broth dilution method | 2017 | Bioorganic & medicinal chemistry letters, 05-15, Volume: 27, Issue:10 | Design, synthesis, and in vitro evaluation of novel antifungal triazoles. |
| AID1557095 | Cytotoxicity against human HEK293T cells assessed as reduction in cell viability at 5 to 50 uM incubated for 24 hrs by XTT assay relative to control | 2019 | European journal of medicinal chemistry, Oct-01, Volume: 179 | Antifungal activity, mode of action variability, and subcellular distribution of coumarin-based antifungal azoles. |
| AID977599 | Inhibition of sodium fluorescein uptake in OATP1B1-transfected CHO cells at an equimolar substrate-inhibitor concentration of 10 uM | 2013 | Molecular pharmacology, Jun, Volume: 83, Issue:6 | Structure-based identification of OATP1B1/3 inhibitors. |
| AID1491343 | Antifungal activity against Aspergillus fumigatus 293 after 48 hrs by two-fold serial dilution method | 2017 | European journal of medicinal chemistry, Sep-08, Volume: 137 | Synthesis, antimicrobial, antiquorum-sensing and antitumor activities of new benzimidazole analogs. |
| AID542094 | Antifungal activity against Trichosporon asahii ATCC 90039 after 24 hrs by microdilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Discovery of a small-molecule inhibitor of {beta}-1,6-glucan synthesis. |
| AID754923 | Antifungal activity against Candida tropicalis 156 assessed as growth inhibition after 24 to 48 hrs by microbroth dilution method | 2013 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 23, Issue:12 | Synthesis and antimycobacterial evaluation of N-substituted 5-chloropyrazine-2-carboxamides. |
| AID1155872 | Antifungal activity against Candida albicans assessed as growth inhibition after 24 hrs by serial dilution method | 2014 | European journal of medicinal chemistry, Jul-23, Volume: 82 | Design, synthesis and antifungal activity of novel triazole derivatives containing substituted 1,2,3-triazole-piperdine side chains. |
| AID1877858 | Antifungal activity against Candida albicans ATCC14053 assessed as hyphal growth at 1 ug/mL by microscopic analysis | 2022 | Bioorganic & medicinal chemistry letters, 02-15, Volume: 58 | Synthesis and antifungal evaluation of phenol-derived bis(indolyl)methanes combined with FLC against Candida albicans. |
| AID1738733 | Inhibition of CYP51 in azole-resistant Candida albicans ATCC SC531 assessed as Obtusifoliol level at 0.03125 ug/ml incubated for 16 hrs by LC-MS analysis relative to control | 2020 | European journal of medicinal chemistry, Jul-15, Volume: 198 | Design, synthesis, and biological evaluation of novel miconazole analogues containing selenium as potent antifungal agents. |
| AID619187 | Antifungal activity against Candida parapsilosis AV 7675 by broth dilution method | 2011 | Journal of medicinal chemistry, Oct-13, Volume: 54, Issue:19 | High-throughput-screening-based identification and structure-activity relationship characterization defined (S)-2-(1-aminoisobutyl)-1-(3-chlorobenzyl)benzimidazole as a highly antimycotic agent nontoxic to cell lines. |
| AID1413583 | Inhibition of CYP51 in Candida albicans SC5314 assessed as eburicol content at 8 ug/ml after 16 hrs by GC/MS analysis relative to control | |||
| AID603345 | Antifungal activity against Trichophyton rubrum clinical isolate by micro-broth dilution method | 2011 | European journal of medicinal chemistry, Jul, Volume: 46, Issue:7 | Design, synthesis and molecular docking studies of novel triazole as antifungal agent. |
| AID518648 | Antimicrobial activity against Cryptococcus gattii serotype C isolate NIH298 assessed as heteroresistant isolates at 4 ug/ml | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Heteroresistance of Cryptococcus gattii to fluconazole. |
| AID1076847 | Antifungal activity against mature preformed Candida albicans ATCC 10231 biofilm by XTT reduction assay | 2014 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 24, Issue:6 | Activity of caffeic acid derivatives against Candida albicans biofilm. |
| AID518183 | Antimicrobial activity against Cryptococcus gattii serotype B isolate NIH286 assessed as heteroresistant isolates at 2 ug/ml | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Heteroresistance of Cryptococcus gattii to fluconazole. |
| AID323598 | Antifungal activity against Candida tropicalis bloodstream isolates by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5 | In vitro activities of isavuconazole and other antifungal agents against Candida bloodstream isolates. |
| AID518434 | Antimicrobial activity against Cryptococcus gattii serotype B isolate NIH184 assessed as heteroresistant isolates at 4 ug/ml | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Heteroresistance of Cryptococcus gattii to fluconazole. |
| AID388083 | Antifungal activity at Benjaminiella poitrasii | 2008 | Bioorganic & medicinal chemistry letters, Oct-15, Volume: 18, Issue:20 | Synthesis of chimeric tetrapeptide-linked cholic acid derivatives: impending synergistic agents. |
| AID737326 | Antimicrobial activity against Aspergillus niger MTCC 281 at 500 ug/ml after 72 hrs by cup plate method | 2013 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 23, Issue:7 | Synthesis of novel 2-amino-4-(5'-substituted 2'-phenyl-1H-indol-3'-yl)-6-aryl-4H-pyran-3-carbonitrile derivatives as antimicrobial and antioxidant agents. |
| AID1728520 | Inhibition of CYP51 in Candida albicans ATCC SC5314 assessed as unknown sterol level at 4 ug/ml incubated for 48 hrs by LC/MS analysis | 2021 | European journal of medicinal chemistry, Jan-15, Volume: 210 | Novel naphthylamide derivatives as dual-target antifungal inhibitors: Design, synthesis and biological evaluation. |
| AID1601669 | Antibiofilm activity against Candida albicans ATCC 10261 assessed as inhibition of mature biofilm formation by XTT reduction assay | |||
| AID625291 | Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for liver function tests abnormal | 2011 | PLoS computational biology, Dec, Volume: 7, Issue:12 | Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). |
| AID1444340 | Antifungal activity against Candida krusei E28 after 24 hrs by broth microdilution method | 2017 | European journal of medicinal chemistry, Apr-21, Volume: 130 | Structure-activity relationship studies on 3,5-dinitrophenyl tetrazoles as antitubercular agents. |
| AID1287101 | Antimicrobial activity against Escherichia coli ATCC 25922 assessed as inhibition of bacterial growth after 16 hrs by broth dilution method | 2016 | Journal of medicinal chemistry, Mar-10, Volume: 59, Issue:5 | A Designed Tryptophan- and Lysine/Arginine-Rich Antimicrobial Peptide with Therapeutic Potential for Clinical Antibiotic-Resistant Candida albicans Vaginitis. |
| AID1689239 | Antifungal activity against Candida albicans SS5314 assessed as reduction in fungal growth incubated for 24 hrs by CLSI based broth microdilution method | 2020 | European journal of medicinal chemistry, Mar-01, Volume: 189 | Oxadiazolylthiazoles as novel and selective antifungal agents. |
| AID672347 | Antifungal activity against Aspergillus flavus KCCM 11899 after 2 days | 2012 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 22, Issue:15 | Synthesis, antitubercular and antimicrobial evaluation of 3-(4-chlorophenyl)-4-substituted pyrazole derivatives. |
| AID416849 | Antifungal activity against Trichophyton mentagrophytes DUMC112.02 by CLSI protocol | 2007 | Antimicrobial agents and chemotherapy, Oct, Volume: 51, Issue:10 | Targeting the calcineurin pathway enhances ergosterol biosynthesis inhibitors against Trichophyton mentagrophytes in vitro and in a human skin infection model. |
| AID287825 | Antifungal activity against Candida glabrata 20/I after 24 hrs | 2007 | Bioorganic & medicinal chemistry, Apr-15, Volume: 15, Issue:8 | Hybrid molecules of estrone: new compounds with potential antibacterial, antifungal, and antiproliferative activities. |
| AID519061 | Antifungal activity against Candida albicans assessed as resistant isolates after 48 hrs by broth microdilution | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | Antimicrobial activity of omiganan pentahydrochloride against contemporary fungal pathogens responsible for catheter-associated infections. |
| AID372232 | Effect on CDR1 RNA level in Candida albicans SSK21 at MIC after 120 mins by RT-PCR | 2007 | Antimicrobial agents and chemotherapy, Oct, Volume: 51, Issue:10 | The Ssk1p response regulator and Chk1p histidine kinase mutants of Candida albicans are hypersensitive to fluconazole and voriconazole. |
| AID382592 | Antimicrobial activity against Candida albicans ATCC 10231 | 2008 | European journal of medicinal chemistry, Feb, Volume: 43, Issue:2 | Synthesis and antimicrobial activity of some novel derivatives of benzofuran: part 2. The synthesis and antimicrobial activity of some novel 1-(1-benzofuran-2-yl)-2-mesitylethanone derivatives. |
| AID424652 | Antimicrobial activity against azole-resistant Candida albicans isolate CA10 assessed as growth at 1 ug/ml cotreated with 0.063 ug/ml calcineurin signaling inhibitor Tacrolimus after 48 hrs by microdilution checkboard technique relative to control | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | In vitro interactions between tacrolimus and azoles against Candida albicans determined by different methods. |
| AID424880 | Antimicrobial activity against azole-resistant Candida albicans isolate CA10 assessed as growth at 1 ug/ml cotreated with 0.031 ug/ml calcineurin signaling inhibitor tacrolimus after 48 hrs by microdilution checkerboard technique relative to control | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | In vitro interactions between tacrolimus and azoles against Candida albicans determined by different methods. |
| AID143929 | Compound was evaluated for its inhibitory activity against Candida albicans N-myristoyltransferase (CaNmt); Not tested | 2001 | Bioorganic & medicinal chemistry letters, Jul-23, Volume: 11, Issue:14 | Design and synthesis of novel benzofurans as a new class of antifungal agents targeting fungal N-myristoyltransferase. Part 1. |
| AID747355 | Antifungal activity against Candida albicans by NCCLS method | 2013 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 23, Issue:11 | Synthesis and biological evaluation of a class of quinolone triazoles as potential antimicrobial agents and their interactions with calf thymus DNA. |
| AID1755828 | Antimicrobial activity against Candida albicans ATCC 90023 | 2021 | European journal of medicinal chemistry, Jan-15, Volume: 210 | Metronidazole-conjugates: A comprehensive review of recent developments towards synthesis and medicinal perspective. |
| AID245569 | In vitro concentration required to inhibit 80% growth of Saccharomyces cerevisiae strain Y218 (CgCDR2 over-expressed) after 48 h | 2004 | Bioorganic & medicinal chemistry letters, Oct-18, Volume: 14, Issue:20 | Quinazolinone fungal efflux pump inhibitors. Part 2: In vitro structure-activity relationships of (N-methyl-piperazinyl)-containing derivatives. |
| AID550087 | Antifungal activity against Candida parapsilosis after 48 hrs by broth microdilution assay | 2011 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 21, Issue:1 | Design and synthesis of 3-(azol-1-yl)phenylpropanes as microbicidal spermicides for prophylactic contraception. |
| AID603897 | Antifungal activity against Candida albicans MTCC 227 after 18 hrs by microtiter broth dilution method | 2011 | European journal of medicinal chemistry, Jul, Volume: 46, Issue:7 | Total synthesis of racemic and (R) and (S)-4-methoxyalkanoic acids and their antifungal activity. |
| AID584390 | Antifungal activity against 14 days cultured Candida glabrata isolated from HSCT recipient with acute or chronic GVHD mouth after 17 days of prophylaxis by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Impact of antifungal prophylaxis on colonization and azole susceptibility of Candida species. |
| AID531179 | Antifungal activity against Trichophyton mentagrophytes ATCC MYA-4439 at 163.3 uM after 5 days by CLSI method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Potent in vitro antifungal activities of naturally occurring acetylenic acids. |
| AID1239801 | Inhibition of Candida albicans lanosterol 14-alpha demethylase assessed as reduction of ergosterol biosynthesis at 10 ug/ml after 18 hrs by UV spectroscopy analysis | 2015 | Bioorganic & medicinal chemistry letters, Sep-01, Volume: 25, Issue:17 | Design, synthesis and evaluation of benzotriazole derivatives as novel antifungal agents. |
| AID1898160 | Antifungal activity against Candida albicans 25# | |||
| AID1918340 | Antifungal activity against fluconazole-resistant Candida albicans 901 assessed as inhibition of fungal growth measured after 72 hrs by CLSI based liquid medium dilution method | 2022 | Journal of medicinal chemistry, 11-10, Volume: 65, Issue:21 | Novel Aryl Alkamidazole Derivatives as Multifunctional Antifungal Inhibitors: Design, Synthesis, and Biological Evaluation. |
| AID1179570 | Antibacterial activity against Pseudomonas aeruginosa MTCC 201 at 100 ug/well after 24 hrs by well diffusion assay | 2014 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 24, Issue:15 | Synthesis and SAR study of novel anticancer and antimicrobial naphthoquinone amide derivatives. |
| AID551209 | Antifungal activity against Trichophyton rubrum by broth microdilution method | 2011 | Bioorganic & medicinal chemistry letters, Jan-15, Volume: 21, Issue:2 | New azoles with antifungal activity: Design, synthesis, and molecular docking. |
| AID581875 | Antifungal activity against Candida glabrata isolated from neutropenic subject 1497 with AML or MDS pharynx receiving antifungal drug after 61 days prophylaxis by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Impact of antifungal prophylaxis on colonization and azole susceptibility of Candida species. |
| AID719029 | Antifungal activity against Trichosporon asahii 1188 assessed as growth inhibition after 24 hrs by CLSI M27-A2 broth microdilution method | 2012 | Bioorganic & medicinal chemistry, Dec-15, Volume: 20, Issue:24 | Anti-infective and herbicidal activity of N-substituted 2-aminobenzothiazoles. |
| AID1309058 | Antifungal activity against Aspergillus terreus ATCC MYA3633 after 48 hrs by CLSI M38-A2 method | 2016 | Bioorganic & medicinal chemistry, 08-15, Volume: 24, Issue:16 | Synthesis and investigation of novel benzimidazole derivatives as antifungal agents. |
| AID424911 | Antimicrobial activity against azole-resistant Candida albicans isolate CA10 assessed as growth at 0.25 ug/ml cotreated with 0.004 ug/ml calcineurin signaling inhibitor Tacrolimus after 48 hrs by microdilution checkboard technique relative to control | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | In vitro interactions between tacrolimus and azoles against Candida albicans determined by different methods. |
| AID511028 | Antimicrobial activity against Aspergillus niger assessed as inhibition of mycelial growth by poisoned food method | 2010 | European journal of medicinal chemistry, Sep, Volume: 45, Issue:9 | Hypervalent iodine(III) mediated synthesis of novel unsymmetrical 2,5-disubstituted 1,3,4-oxadiazoles as antibacterial and antifungal agents. |
| AID1592225 | Antifungal activity against Candida albicans assessed as reduction in proportion of microbes at cell division phase at 25 to 250 nM/mL by polarizing microscopy | 2019 | Bioorganic & medicinal chemistry, 06-15, Volume: 27, Issue:12 | Design, synthesis and biological evaluation of amide-pyridine derivatives as novel dual-target (SE, CYP51) antifungal inhibitors. |
| AID518876 | Antimicrobial activity against Cryptococcus gattii serotype C isolate H0058-1-1941 assessed as heteroresistant isolates at 16 ug/ml | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Heteroresistance of Cryptococcus gattii to fluconazole. |
| AID546080 | Antifungal activity against Candida pulcherrima isolated from candidemia patient by AFST-EUCAST microdilution method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | A 10-year survey of antifungal susceptibility of candidemia isolates from intensive care unit patients in Greece. |
| AID561429 | Antifungal activity against Candida lusitaniae CL31 by microdilution method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Nonsense and missense mutations in FCY2 and FCY1 genes are responsible for flucytosine resistance and flucytosine-fluconazole cross-resistance in clinical isolates of Candida lusitaniae. |
| AID1732416 | Antifungal activity against Cryptococcus neoformans var. grubii ATCC 208821 assessed as growth inhibition at 32 ug/ml after 36 hrs by monochromator plate assay relative to control | 2021 | Bioorganic & medicinal chemistry letters, 05-01, Volume: 39 | Design, synthesis and bioactivity evaluation of novel pyrazole linked phenylthiazole derivatives in context of antibacterial activity. |
| AID1427507 | Antifungal activity against Aspergillus niger MTCC 8189 after 48 hrs by broth microdilution method | 2017 | Bioorganic & medicinal chemistry, 03-15, Volume: 25, Issue:6 | Synthesis of 1,3,5-trisubstituted pyrazolines as potential antimalarial and antimicrobial agents. |
| AID283845 | Antifungal activity against Penicillium marneffei after 3 to 4 days by serial plate dilution method | 2007 | European journal of medicinal chemistry, Jan, Volume: 42, Issue:1 | Synthesis and antimicrobial studies on novel chloro-fluorine containing hydroxy pyrazolines. |
| AID1348791 | Antifungal activity against Trichophyton mentagrophytes after 48 hrs by broth microdilution method | 2018 | European journal of medicinal chemistry, Jan-01, Volume: 143 | Substituted carbamothioic amine-1-carbothioic thioanhydrides as novel trichomonicidal fungicides: Design, synthesis, and biology. |
| AID1886000 | Antifungal activity against Cryptococcus neoformans clinical isolate 445 assessed as fungal growth inhibition incubated for 72 hrs in presence of P163-0892 by broth microdilution method | |||
| AID1885965 | Antifungal activity against Cryptococcus neoformans clinical isolate HN1 assessed as fungal growth inhibition incubated for 72 hrs by broth microdilution method | |||
| AID582781 | Antifungal activity against Candida albicans isolate 12 harboring ERG3 W332R mutant gene assessed as 14alpha-methylergosta-8,24(28)-dien-3beta,6alpha-diol content in total sterol composition at 0.5 times MIC by GC-MS analysis | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | Identification and characterization of four azole-resistant erg3 mutants of Candida albicans. |
| AID1419524 | Effect on sterol composition in Candida albicans ATCC 10231 assessed as eburicol level at 0.125 ug/mL incubated for 10 mins by LC-MS analysis | 2017 | European journal of medicinal chemistry, Jun-16, Volume: 133 | Novel alkylated azoles as potent antifungals. |
| AID1138335 | Antimicrobial activity against fluconazole-resistant Candida albicans J18 after 24 hrs by serial dilution method | 2014 | Journal of medicinal chemistry, May-08, Volume: 57, Issue:9 | Design, synthesis, and structure-activity relationship studies of novel fused heterocycles-linked triazoles with good activity and water solubility. |
| AID518670 | Antimicrobial activity against Cryptococcus gattii serotype B isolate RAM002 assessed as heteroresistant isolates at 8 ug/ml | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Heteroresistance of Cryptococcus gattii to fluconazole. |
| AID424641 | Antimicrobial activity against azole-resistant Candida albicans isolate CA10 assessed as growth at 1 ug/ml co-treated with 0.125 ug/ml calcineurin signaling inhibitor tacrolimus after 48 hrs by microdilution checkboard technique relative to control | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | In vitro interactions between tacrolimus and azoles against Candida albicans determined by different methods. |
| AID1419493 | Antifungal activity against Candida albicans ATCC 10231 incubated for 48 hrs by modified CLSI M27-A3 protocol based method | 2017 | European journal of medicinal chemistry, Jun-16, Volume: 133 | Novel alkylated azoles as potent antifungals. |
| AID519057 | Antifungal activity against Candida glabrata assessed as susceptible isolates after 48 hrs by broth microdilution | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | Antimicrobial activity of omiganan pentahydrochloride against contemporary fungal pathogens responsible for catheter-associated infections. |
| AID531094 | Antimicrobial activity against Candida albicans YNM11 harboring cyp56delta::FRT/cyp56::FRT mutant gene by Etest method | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | CYP56 (Dit2p) in Candida albicans: characterization and investigation of its role in growth and antifungal drug susceptibility. |
| AID1242643 | Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC 29213 after 16 hrs by microtiter broth dilution method | 2015 | ACS medicinal chemistry letters, Jul-09, Volume: 6, Issue:7 | Novel Chalcone-Thiazole Hybrids as Potent Inhibitors of Drug Resistant Staphylococcus aureus. |
| AID1413333 | Antifungal activity against Candida albicans B-311 | 2018 | MedChemComm, Jun-01, Volume: 9, Issue:6 | Antifungal amphiphilic kanamycins: new life for an old drug. |
| AID530739 | Antifungal activity against Candida albicans ATCC 32354 at 163.3 uM after 48 hrs by CLSI method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Potent in vitro antifungal activities of naturally occurring acetylenic acids. |
| AID582241 | Antifungal activity against Candida albicans isolated from HSCT recipients with acute or chronic GVHD receiving fluconazole assessed as maximum MIC by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Impact of antifungal prophylaxis on colonization and azole susceptibility of Candida species. |
| AID1239971 | Antifungal activity against Candida mycoderma ATCC 9888 after 24 hrs by microbroth dilution method | 2015 | Bioorganic & medicinal chemistry letters, Sep-01, Volume: 25, Issue:17 | Design and biological evaluation of novel quinolone-based metronidazole derivatives as potent Cu(2+) mediated DNA-targeting antibacterial agents. |
| AID1456580 | Antifungal activity against Candida glabrata isolate 537 by micro-broth dilution method | 2017 | Bioorganic & medicinal chemistry letters, 05-15, Volume: 27, Issue:10 | Design, synthesis, and in vitro evaluation of novel antifungal triazoles. |
| AID1418529 | Antifungal activity against fluconazole-sensitive Candida albicans ATCC SC5314 after 2 to 7 days by broth microdilution method | 2018 | Bioorganic & medicinal chemistry letters, 12-01, Volume: 28, Issue:22 | Design, synthesis, and biological evaluation of 4-chloro-2H-thiochromenes featuring nitrogen-containing side chains as potent antifungal agents. |
| AID444054 | Oral bioavailability in human | 2010 | Journal of medicinal chemistry, Feb-11, Volume: 53, Issue:3 | Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. |
| AID1557087 | Antifungal activity against Candida glabrata ATCC 66032 assessed as reduction in fungal cell growth incubated for 48 hrs by MTT based broth double dilution method | 2019 | European journal of medicinal chemistry, Oct-01, Volume: 179 | Antifungal activity, mode of action variability, and subcellular distribution of coumarin-based antifungal azoles. |
| AID572703 | Binding affinity to Mycobacterium tuberculosis CYP121 | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Identification, characterization, and azole-binding properties of Mycobacterium smegmatis CYP164A2, a homolog of ML2088, the sole cytochrome P450 gene of Mycobacterium leprae. |
| AID493513 | Antifungal activity against Candida tropicalis 159 after 24 hrs by broth microdilution assay | 2010 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 20, Issue:15 | N-Benzylsalicylthioamides as novel compounds with promising antimycotic activity. |
| AID521988 | Antibacterial activity against Fluconazole resistant Candida albicans DSY3706 containing tac1delta/delta ERG11-1/ERG11-1 genotype infected in BALB/c mouse assessed as weight change administered intraperitoneally 1 hr post bacterial challenge measured 3 da | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Genetic dissection of azole resistance mechanisms in Candida albicans and their validation in a mouse model of disseminated infection. |
| AID1369487 | Antifungal activity against Candida albicans cgmcc 2.2086 in presence of 12.5% human heat-inactivated serum by broth dilution method | 2018 | Journal of medicinal chemistry, 05-10, Volume: 61, Issue:9 | Combating Drug-Resistant Fungi with Novel Imperfectly Amphipathic Palindromic Peptides. |
| AID588211 | Literature-mined compound from Fourches et al multi-species drug-induced liver injury (DILI) dataset, effect in humans | 2010 | Chemical research in toxicology, Jan, Volume: 23, Issue:1 | Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. |
| AID1367153 | Antifungal activity against Candida krusei E28 after 24 hrs by microdilution broth method | 2017 | Bioorganic & medicinal chemistry letters, 12-01, Volume: 27, Issue:23 | Synthesis and biological evolution of hydrazones derived from 4-(trifluoromethyl)benzohydrazide. |
| AID1877306 | Antibiofilm activity against FLC-resistant Candida albicans CPCC400616 assessed as assessed as inhibition of biofilm formation measured at 18 hrs by XTT reduction assay | 2022 | European journal of medicinal chemistry, Jan-05, Volume: 227 | Broadening antifungal spectrum and improving metabolic stablity based on a scaffold strategy: Design, synthesis, and evaluation of novel 4-phenyl-4,5-dihydrooxazole derivatives as potent fungistatic and fungicidal reagents. |
| AID495358 | Antimicrobial activity against Candida albicans isolate SC5314 expressing UPC2/UPC2 G648D mutant allele by microdilution method relative wild type | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | An A643T mutation in the transcription factor Upc2p causes constitutive ERG11 upregulation and increased fluconazole resistance in Candida albicans. |
| AID675303 | Antibacterial activity against Bacillus subtilis ATCC 6633 by two fold broth dilution method | 2012 | Bioorganic & medicinal chemistry letters, Sep-01, Volume: 22, Issue:17 | Design, synthesis and evaluation of clinafloxacin triazole hybrids as a new type of antibacterial and antifungal agents. |
| AID1246675 | Antifungal activity against Cryptococcus neoformans 5396 assessed as reduction in cell viability at 26 uM after 6 to 72 hrs by MTT assay | 2015 | European journal of medicinal chemistry, Sep-18, Volume: 102 | Thiazole compounds with activity against Cryptococcus gattii and Cryptococcus neoformans in vitro. |
| AID518692 | Antimicrobial activity against Cryptococcus gattii serotype B isolate B5765 assessed as heteroresistant isolates at 16 ug/ml | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Heteroresistance of Cryptococcus gattii to fluconazole. |
| AID1369447 | Antifungal activity against Candida albicans SP3876 after 48 hrs by broth microdilution method | 2018 | Journal of medicinal chemistry, 05-10, Volume: 61, Issue:9 | Combating Drug-Resistant Fungi with Novel Imperfectly Amphipathic Palindromic Peptides. |
| AID1405055 | Antifungal activity against Candida albicans assessed as ratio of MIC after and before 10 serial passages | 2018 | European journal of medicinal chemistry, Jul-15, Volume: 155 | Novel carbazole-triazole conjugates as DNA-targeting membrane active potentiators against clinical isolated fungi. |
| AID1471214 | Antifungal activity against Candida albicans by spectrophotometric method | 2017 | Bioorganic & medicinal chemistry letters, 07-01, Volume: 27, Issue:13 | Diversity-oriented sustainable synthesis of antimicrobial spiropyrrolidine/thiapyrrolizidine oxindole derivatives: New ligands for a metallo-β-lactamase from Klebsiella pneumonia. |
| AID522128 | Antimicrobial activity against calcineurin deltacnb1 mutant containing Candida glabrata TG163 complemented with CNB1 gene by colorimetric microdilution method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Roles of calcineurin and Crz1 in antifungal susceptibility and virulence of Candida glabrata. |
| AID136420 | In vivo antifungal activity was evaluated in target organ kidney assay (TOKA) in mice infected with Candida albicans CY 10025 X 10e5 cell after intravenous administration of compound at 1 mg/kg | 2000 | Bioorganic & medicinal chemistry letters, Jul-03, Volume: 10, Issue:13 | Synthesis and structure-activity relationships of novel fungal chitin synthase inhibitors. |
| AID1060887 | Antifungal activity against Candida mycoderma ATCC 96918 after 24 hrs by micro broth dilution method | 2014 | European journal of medicinal chemistry, Jan, Volume: 71 | Synthesis and biological evaluation of α-triazolyl chalcones as a new type of potential antimicrobial agents and their interaction with calf thymus DNA and human serum albumin. |
| AID1060929 | Antimicrobial activity against Saccharomyces cerevisiae by two-fold serial dilution method | 2014 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 24, Issue:1 | 1,2,3-Triazole-derived naphthalimides as a novel type of potential antimicrobial agents: synthesis, antimicrobial activity, interaction with calf thymus DNA and human serum albumin. |
| AID1758031 | Inhibition of CYP51 in Candida albicans ATCC SC5314 assessed as Obtusifoliol level at 0.03125 ug/ml after 16 hrs by GC-MS analysis (Rvb = 0%) | 2021 | European journal of medicinal chemistry, Apr-15, Volume: 216 | Lead optimization generates selenium-containing miconazole CYP51 inhibitors with improved pharmacological profile for the treatment of fungal infections. |
| AID1061743 | Antimicrobial activity against Candida albicans Y0109 after 24 hrs by broth microdilution method | 2014 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 24, Issue:1 | Synthesis and evaluation of novel azoles as potent antifungal agents. |
| AID538386 | Antifungal activity against Microsporum gypseum clinical isolate by serial dilution method | 2010 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 20, Issue:23 | Synthesis and in vitro antifungal activities of new 3-substituted benzopyrone derivatives. |
| AID653256 | Antifungal activity against Candida parapsilosis ATCC 69548 after 24 hrs by broth microdilution method | 2012 | Bioorganic & medicinal chemistry, Apr-15, Volume: 20, Issue:8 | Semisynthesis and antimicrobial activity of novel guttiferone-A derivatives. |
| AID515015 | Antifungal activity against Aspergillus fumigatus by micro-broth dilution method | 2010 | European journal of medicinal chemistry, Oct, Volume: 45, Issue:10 | Synthesis and antifungal evaluation of novel triazole derivatives as inhibitors of cytochrome P450 14alpha-demethylase. |
| AID582800 | Antifungal activity against Candida albicans isolate 488 harboring ERG3 H243N, T330A, A351V and ERG11 D225G, E266D, E391G, V488I mutant genes by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | Identification and characterization of four azole-resistant erg3 mutants of Candida albicans. |
| AID530962 | Antifungal activity against Candida krusei ATCC 6258 after 48 hrs by CLSI method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Potent in vitro antifungal activities of naturally occurring acetylenic acids. |
| AID1572494 | Fungicidal activity against Cryptococcus neoformans var. grubii H99 at 16 ug/mL after 48 hrs by time-kill assay | 2019 | Bioorganic & medicinal chemistry, 03-01, Volume: 27, Issue:5 | Discovery of novel simplified isoxazole derivatives of sampangine as potent anti-cryptococcal agents. |
| AID1154030 | Antifungal activity against Aspergillus flavus after 48 hrs by disc diffusion method | 2014 | Bioorganic & medicinal chemistry, Jul-01, Volume: 22, Issue:13 | Design, synthesis and evaluation of novel quinazoline-2,4-dione derivatives as chitin synthase inhibitors and antifungal agents. |
| AID1890295 | Inhibition of CYP51 in mouse NIH/3T3 cells assessed as specific enzymatic activity at 150 ug/ml incubated for 48 hrs by ELISA analysis | 2022 | Bioorganic & medicinal chemistry letters, 05-01, Volume: 63 | Novel 2-aryl-4-aryloxyquinoline-based fungistatics for Mucor circinelloides. Biological evaluation of activity, QSAR and docking study. |
| AID632572 | Antifungal activity against Candida albicans NCIM 3417 by agar diffusion method | 2011 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 21, Issue:24 | Molecular properties prediction and synthesis of novel 1,3,4-oxadiazole analogues as potent antimicrobial and antitubercular agents. |
| AID1329222 | Inhibition of CDR1/CDR2 in Candida albicans clinical isolate 18I assessed as potentiation of fluconazole-induced antifungal activity by measuring fluconazole MIC80 up to 8 ug/ml after 24 hrs by XTT based broth microdilution assay (Rvb = >128 ug/ml) | 2016 | Journal of natural products, 09-23, Volume: 79, Issue:9 | Heptaketides from an Endolichenic Fungus Biatriospora sp. and Their Antifungal Activity. |
| AID518883 | Antimicrobial activity against Cryptococcus gattii serotype B isolate RB14 assessed as heteroresistant isolates at 32 ug/ml | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Heteroresistance of Cryptococcus gattii to fluconazole. |
| AID1055723 | Antifungal activity against Aspergillus flavus after 24 to 48 hrs by agar well diffusion method | 2013 | European journal of medicinal chemistry, , Volume: 70 | Solution-phase microwave assisted parallel synthesis of N,N'-disubstituted thioureas derived from benzoic acid: biological evaluation and molecular docking studies. |
| AID1162142 | Antifungal activity against Aspergillus flavus ATCC 96918 after 24 hrs by microbroth dilution method | 2014 | European journal of medicinal chemistry, Oct-30, Volume: 86 | Novel hybrids of metronidazole and quinolones: synthesis, bioactive evaluation, cytotoxicity, preliminary antimicrobial mechanism and effect of metal ions on their transportation by human serum albumin. |
| AID1867443 | Induction of ROS generation in fluconazole resistant Saccharomyces cerevisiae overexpressing CgCdr1p transporter assessed as increase in ROS level incubated for 90 mins by DCFH-DA dye based fluorescence assay | 2022 | Bioorganic & medicinal chemistry, 06-01, Volume: 63 | Effects of β-lapachone and β-nor-lapachone on multidrug efflux transporters and biofilms of Candida glabrata. |
| AID1759444 | Hemolytic activity in human RBC at 2 ug/ml incubated for 30 mins | 2021 | Bioorganic & medicinal chemistry letters, 06-01, Volume: 41 | Inhibitory effects and mechanism of antifungal action of the natural cyclic depsipeptide, aureobasidin A against Cryptococcus neoformans. |
| AID285704 | Decrease in mortality of neonatal Wistar rat infected with Candida albicans ATCC 32354 and Staphylococcus epidermidis Hay at 10 mg/kg of body weight/day, ip for 4 days beginning 24 hrs before infection | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Neonatal coinfection model of coagulase-negative Staphylococcus (Staphylococcus epidermidis) and Candida albicans: fluconazole prophylaxis enhances survival and growth. |
| AID1168327 | Binding affinity to human serum albumin at 298 K by modified Stern-Volmer method | 2014 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 24, Issue:21 | Study the interactions between human serum albumin and two antifungal drugs: fluconazole and its analogue DTP. |
| AID454196 | Antifungal activity against Fusarium oxysporum NCIM 1332 by standard agar plate method | 2010 | Bioorganic & medicinal chemistry letters, Jan-15, Volume: 20, Issue:2 | One pot synthesis and SAR of some novel 3-substituted 5,6-diphenyl-1,2,4-triazines as antifungal agents. |
| AID302120 | Antifungal activity against Aspergillus fumigatus | 2007 | Journal of medicinal chemistry, Nov-01, Volume: 50, Issue:22 | Synthesis and antifungal activities of novel 2-aminotetralin derivatives. |
| AID717777 | Antimicrobial activity against Candida krusei ATCC 6258 after 48 hrs by broth microdilution test | 2012 | Bioorganic & medicinal chemistry, Dec-15, Volume: 20, Issue:24 | Contribution to investigation of antimicrobial activity of styrylquinolines. |
| AID1246583 | Antifungal activity against Cryptococcus gattii ICB181 after 48 to 72 hrs by broth microdilution method | 2015 | European journal of medicinal chemistry, Sep-18, Volume: 102 | Thiazole compounds with activity against Cryptococcus gattii and Cryptococcus neoformans in vitro. |
| AID1886052 | Synergistic antifungal activity against Cryptococcus gattii clinical isolate SCZ20031 assessed as fractional inhibitory concentration index incubated for 72 hrs in presence of P163-0892 by broth microdilution method | |||
| AID1770939 | Antifungal activity against Candida tropicalis CGMCC 2.3739 assessed as fungal growth inhibition by CLSI protocol based method | 2021 | European journal of medicinal chemistry, Dec-05, Volume: 225 | Design, synthesis and evaluation of novel 5-phenylthiophene derivatives as potent fungicidal of Candida albicans and antifungal reagents of fluconazole-resistant fungi. |
| AID448156 | Antimicrobial activity against Escherichia coli ATCC 25922 at 5 ug after 18 hrs by well diffusion method | 2009 | European journal of medicinal chemistry, Nov, Volume: 44, Issue:11 | Synthesis of some new 1,2,4-triazoles starting from isonicotinic acid hydrazide and evaluation of their antimicrobial activities. |
| AID665130 | Antifungal activity against 3 strains of Candida krusei after 24 hrs by EUCAST broth microdilution method | 2012 | European journal of medicinal chemistry, Jul, Volume: 53 | Synthesis, anti-Candida activity, and cytotoxicity of new (4-(4-iodophenyl)thiazol-2-yl)hydrazine derivatives. |
| AID719309 | Antimicrobial activity against Pseudomonas aeruginosa NCIM 5029 by broth dilution method | 2012 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 22, Issue:23 | Synthesis, characterization, antidepressant and antioxidant activity of novel piperamides bearing piperidine and piperazine analogues. |
| AID494616 | Ratio of MIC for Saccharomyces cerevisiae KE744 to Saccharomyces cerevisiae KE743 overexpressing GWT1 | 2010 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 20, Issue:15 | Synthesis and evaluation of novel antifungal agents-quinoline and pyridine amide derivatives. |
| AID1689234 | Antibiofilm activity against 24 hrs preformed biofilm of Candida albicans NR29448 assessed as disruption of mature biofilm at 64 ug/ml incubated for 24 hrs by crystal violet staining based spectrophotometry relative to control | 2020 | European journal of medicinal chemistry, Mar-01, Volume: 189 | Oxadiazolylthiazoles as novel and selective antifungal agents. |
| AID1742128 | Antifungal activity against Candida glabrata assessed as inhibition of microbial growth by two fold broth microdilution method | 2020 | European journal of medicinal chemistry, Nov-01, Volume: 205 | Design, synthesis and bioactivity evaluation of novel arylalkene-amide derivatives as dual-target antifungal inhibitors. |
| AID457708 | Antifungal activity against Candida albicans ATCC 44859 after 24 hrs by microdilution method | 2010 | Bioorganic & medicinal chemistry, Mar-01, Volume: 18, Issue:5 | Antifungal 3,5-disubstituted furanones: From 5-acyloxymethyl to 5-alkylidene derivatives. |
| AID1157147 | Antifungal activity against Candida albicans ATCC 24433 after 48 hrs by CLSI broth microdilution method | 2014 | European journal of medicinal chemistry, Aug-18, Volume: 83 | Synthesis, biological evaluation and structure-activity correlation study of a series of imidazol-based compounds as Candida albicans inhibitors. |
| AID1674368 | Unbound clearance in human | 2020 | Journal of medicinal chemistry, 11-12, Volume: 63, Issue:21 | Integrating the Impact of Lipophilicity on Potency and Pharmacokinetic Parameters Enables the Use of Diverse Chemical Space during Small Molecule Drug Optimization. |
| AID1491341 | Antibacterial activity against Staphylococcus aureus ATCC 29213 after 24 hrs by two-fold serial dilution method | 2017 | European journal of medicinal chemistry, Sep-08, Volume: 137 | Synthesis, antimicrobial, antiquorum-sensing and antitumor activities of new benzimidazole analogs. |
| AID526815 | Antifungal activity against Candida glabrata ATCC 48435 assessed as concentration required to 50% growth inhibition using alamar blue staining after 18 to 72 hrs by microdilution method | 2010 | Bioorganic & medicinal chemistry, Nov-01, Volume: 18, Issue:21 | 1,3-Benzoxazole-4-carbonitrile as a novel antifungal scaffold of β-1,6-glucan synthesis inhibitors. |
| AID1491253 | Inhibition of CYP51 in Candida albicans ATCC SC5314 assessed as ergosterol content at 0.5 ug/ml by GS-MS analysis relative to total sterols (Rvb = 98.7%) | 2017 | European journal of medicinal chemistry, Sep-08, Volume: 137 | Design, synthesis and evaluation of aromatic heterocyclic derivatives as potent antifungal agents. |
| AID262548 | Antifungal activity against Candida tropicalis | 2006 | Journal of medicinal chemistry, Apr-20, Volume: 49, Issue:8 | Structure-based optimization of azole antifungal agents by CoMFA, CoMSIA, and molecular docking. |
| AID753239 | Antifungal activity against Saccharomyces cerevisiae after 24 hrs by two-fold serial dilution method | 2013 | European journal of medicinal chemistry, Jun, Volume: 64 | Design, synthesis and antimicrobial evaluation of novel benzimidazole type of Fluconazole analogues and their synergistic effects with Chloromycin, Norfloxacin and Fluconazole. |
| AID464589 | Antifungal activity against Candida albicans ATCC 76615 after 24 hrs by two fold serial dilution method | 2010 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 20, Issue:6 | Synthesis, antibacterial and antifungal activities of some carbazole derivatives. |
| AID518654 | Antimicrobial activity against Cryptococcus gattii serotype B isolate NIH184 assessed as heteroresistant isolates at 8 ug/ml | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Heteroresistance of Cryptococcus gattii to fluconazole. |
| AID118053 | In vivo evaluation of % survival rate after peroral administration on 3rd day at dose 20 mg/kg | 1995 | Journal of medicinal chemistry, Sep-29, Volume: 38, Issue:20 | Synthesis and antifungal activity of new azole derivatives containing an N-acylmorpholine ring. |
| AID606212 | Antifungal activity against Candida albicans ATCC Y0109 after 24 hrs by micro-broth dilution method | 2011 | European journal of medicinal chemistry, Jul, Volume: 46, Issue:7 | Design, synthesis and antifungal activities of novel 1,2,4-triazole derivatives. |
| AID547606 | Antifungal activity against Candida glabrata isolate Cg11S | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | Microarray and molecular analyses of the azole resistance mechanism in Candida glabrata oropharyngeal isolates. |
| AID642935 | Antifungal activity against Candida albicans ATCC 14053 at 160 ug/ml | 2011 | ACS medicinal chemistry letters, May-12, Volume: 2, Issue:5 | Natural Product Based 6-Hydroxy-2,3,4,6-tetrahydropyrrolo[1,2-a]pyrimidinium Scaffold as A New Antifungal Template. |
| AID1221961 | Apparent permeability from basolateral to apical side of human Caco2 cells at 10 uM up to 120 mins by HPLC-MC analysis in presence of 1 uM of P-gp inhibitor LY335979 | 2011 | Drug metabolism and disposition: the biological fate of chemicals, Feb, Volume: 39, Issue:2 | Attenuation of intestinal absorption by major efflux transporters: quantitative tools and strategies using a Caco-2 model. |
| AID1254069 | Antibacterial activity against Staphylococcus aureus 503 after 24 hrs by two-fold serial dilution method | 2015 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 25, Issue:22 | Synthesis and biological evaluation of 1,3-diaryl pyrazole derivatives as potential antibacterial and anti-inflammatory agents. |
| AID1877284 | Antifungal activity against Candida glabrata clinical isolate assessed as fungal growth inhibition by NCCLS protocol based method | 2022 | European journal of medicinal chemistry, Jan-05, Volume: 227 | Broadening antifungal spectrum and improving metabolic stablity based on a scaffold strategy: Design, synthesis, and evaluation of novel 4-phenyl-4,5-dihydrooxazole derivatives as potent fungistatic and fungicidal reagents. |
| AID406958 | Antifungal activity against fluconazole-sensitive Candida albicans Fe40 at 35 degC after 48 hrs by broth microdilution test | 2008 | Journal of medicinal chemistry, Jul-10, Volume: 51, Issue:13 | 1-[(3-Aryloxy-3-aryl)propyl]-1H-imidazoles, new imidazoles with potent activity against Candida albicans and dermatophytes. Synthesis, structure-activity relationship, and molecular modeling studies. |
| AID584377 | Ratio of URA3 gene expression in Candida glabrata isolated from patient 497 receiving antifungal drug to URA3 gene expression in Candida glabrata isolated from patient 497 by RT-PCR analysis | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Impact of antifungal prophylaxis on colonization and azole susceptibility of Candida species. |
| AID670734 | Antifungal activity against Aspergillus niger MTCC 2642 by spectrophotometry based assay | 2012 | Bioorganic & medicinal chemistry letters, Jul-15, Volume: 22, Issue:14 | Synthesis and evaluation of novel 3a,9a-dihydro-1-ethoxycarbonyl-1-cyclopenteno[5,4-b]benzopyran-4-ones as antifungal agents. |
| AID747353 | Antibacterial activity against methicillin-resistant Staphylococcus aureus N315 by NCCLS method | 2013 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 23, Issue:11 | Synthesis and biological evaluation of a class of quinolone triazoles as potential antimicrobial agents and their interactions with calf thymus DNA. |
| AID772318 | Antifungal activity against fluconazole-resistant Candida glabrata DSY2254 increase expressing of CgCDR1 and CgCDR2 genes after 24 hrs by visually and spectrophotometric analysis | 2013 | ACS medicinal chemistry letters, Sep-12, Volume: 4, Issue:9 | Novel Macrocyclic Amidinoureas: Potent Non-Azole Antifungals Active against Wild-Type and Resistant Candida Species. |
| AID1557086 | Antifungal activity against Candida albicans SN152 assessed as reduction in fungal cell growth incubated for 48 hrs by MTT based broth double dilution method | 2019 | European journal of medicinal chemistry, Oct-01, Volume: 179 | Antifungal activity, mode of action variability, and subcellular distribution of coumarin-based antifungal azoles. |
| AID398061 | Antifungal activity against Saccharomyces cerevisiae DSY 426 expressing Candida albicans FLU1 after 40 to 48 hrs by serial dilution method | 2003 | Journal of natural products, Dec, Volume: 66, Issue:12 | Reversal of fluconazole resistance in multidrug efflux-resistant fungi by the Dysidea arenaria sponge sterol 9alpha,11alpha-epoxycholest-7-ene-3beta,5alpha,6alpha,19-tetrol 6-acetate. |
| AID495355 | Antimicrobial activity against fluconazole resistant Candida albicans isolate 1619 expressing high levels of ERG11 and UPC2 mRNA by microdilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | An A643T mutation in the transcription factor Upc2p causes constitutive ERG11 upregulation and increased fluconazole resistance in Candida albicans. |
| AID1193508 | Antifungal activity against Aspergillus fumigatus ATCC 1028 after 24 to 168 hrs by broth microdilution assay | 2015 | Bioorganic & medicinal chemistry, Apr-01, Volume: 23, Issue:7 | Synthesis and biological evaluation of fluconazole analogs with triazole-modified scaffold as potent antifungal agents. |
| AID1272751 | Antifungal activity against Penicillium citrinum at 0.13 mol/L after 2 to 4 days by paper disc method | 2016 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 26, Issue:3 | Synthesis, antimicrobial activity of Schiff base compounds of cinnamaldehyde and amino acids. |
| AID568480 | Antifungal activity against Aspergillus niger KCTC 1231 after 2 days by twofold broth dilution method | 2011 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 21, Issue:3 | Synthesis and antifungal activity of furo[2,3-f]quinolin-5-ols. |
| AID584596 | Antifungal activity against 177 days cultured Candida glabrata isolated from HSCT recipient with acute or chronic GVHD mouth receiving antifungal therapy for 172 days after 114 days of prophylaxis by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Impact of antifungal prophylaxis on colonization and azole susceptibility of Candida species. |
| AID741615 | Antifungal activity against Candida tropicalis Berkout KCCM 50662 after 1 day by two fold broth dilution method | 2013 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 23, Issue:7 | Synthesis and antifungal evaluation of 7-arylamino-5,8-dioxo-5,8-dihydroisoquinoline-4-carboxylates. |
| AID1309071 | Antifungal activity against Candida albicans ATCC 10231 after 48 hrs by agar dilution method | 2016 | Bioorganic & medicinal chemistry, 08-15, Volume: 24, Issue:16 | Novel benzimidazol-2-ylidene carbene precursors and their silver(I) complexes: Potential antimicrobial agents. |
| AID1361019 | Antifungal activity against Aspergillus niger MTCC 9933 assessed as zone of growth inhibition after 48 hrs | 2018 | European journal of medicinal chemistry, Jul-15, Volume: 155 | Rational modification of a lead molecule: Improving the antifungal activity of indole - triazole - amino acid conjugates. |
| AID405027 | Antifungal activity against Sporothrix schenckii MRSS4 isolate from cutaneous-lymphatic sporotrichosis patient after 72 hrs by modified NCCLS M38-A method | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | In vitro susceptibility of Sporothrix schenckii to six antifungal agents determined using three different methods. |
| AID772329 | Antifungal activity against fluconazole-resistant Candida albicans DSY284 harboring ERG11 gene mutant and increase expressing of CDR1 and CDR2 genes after 24 hrs by visually and spectrophotometric analysis | 2013 | ACS medicinal chemistry letters, Sep-12, Volume: 4, Issue:9 | Novel Macrocyclic Amidinoureas: Potent Non-Azole Antifungals Active against Wild-Type and Resistant Candida Species. |
| AID554937 | Increase in ERG11 mRNA expression in Candida krusei B2400 at MIC concentration after 80 mins by hot-phenol extraction based Northern blotting | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Abc1p is a multidrug efflux transporter that tips the balance in favor of innate azole resistance in Candida krusei. |
| AID118068 | In vivo evaluation of % survival rate after peroral administration on 7th day at dose 5 mg/kg | 1995 | Journal of medicinal chemistry, Sep-29, Volume: 38, Issue:20 | Synthesis and antifungal activity of new azole derivatives containing an N-acylmorpholine ring. |
| AID394717 | Antifungal activity against Cryptococcus neoformans H99 expressing PCTR4-2/FAS1 assessed as reduction in viable cells at 8 ug/ml after 72 hrs in presence of CuSO4 relative to CuSO4 alone | 2007 | Antimicrobial agents and chemotherapy, Oct, Volume: 51, Issue:10 | Fatty acid synthesis is essential for survival of Cryptococcus neoformans and a potential fungicidal target. |
| AID287819 | Antifungal activity against Candida albicans ATCC 44859 after 24 hrs | 2007 | Bioorganic & medicinal chemistry, Apr-15, Volume: 15, Issue:8 | Hybrid molecules of estrone: new compounds with potential antibacterial, antifungal, and antiproliferative activities. |
| AID1334850 | Anti-fungal activity against Aspergillus fumigatus CGMCC 3.7795 by broth microdilution method | 2017 | Bioorganic & medicinal chemistry, 01-15, Volume: 25, Issue:2 | Discovery of biphenyl imidazole derivatives as potent antifungal agents: Design, synthesis, and structure-activity relationship studies. |
| AID302115 | Antifungal activity against Candida albicans after 24 hrs | 2007 | Journal of medicinal chemistry, Nov-01, Volume: 50, Issue:22 | Synthesis and antifungal activities of novel 2-aminotetralin derivatives. |
| AID535620 | Antifungal activity against Candida tropicalis T26 blood stream isolate harboring Fks1p LLTLSLRDP mutant protein | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | Caspofungin-resistant Candida tropicalis strains causing breakthrough fungemia in patients at high risk for hematologic malignancies. |
| AID719314 | Antimicrobial activity against Escherichia coli NCIM 2574 at 100 ug/mL incubated for 24 hrs by agar disc diffusion method | 2012 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 22, Issue:23 | Synthesis, characterization, antidepressant and antioxidant activity of novel piperamides bearing piperidine and piperazine analogues. |
| AID351877 | Binding affinity to Mycobacterium tuberculosis His4-tagged recombinant CYP51 inhibitor binding site expressed in Escherichia coli HMS174(DE3) by UV-visible spectral titration method | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Small-molecule scaffolds for CYP51 inhibitors identified by high-throughput screening and defined by X-ray crystallography. |
| AID1549156 | Inhibition of CYP51 in azole-resistant Candida albicans 0304103 assessed as unknown sterol 3 level at 0.5 ug/ml after 24 hrs by GC-MS analysis (Rvb = 4.78%) | 2020 | Journal of medicinal chemistry, 05-28, Volume: 63, Issue:10 | Discovery of Novel Fungal Lanosterol 14α-Demethylase (CYP51)/Histone Deacetylase Dual Inhibitors to Treat Azole-Resistant Candidiasis. |
| AID372422 | Antifungal activity against Candida albicans K2 at 32 uM after 16 hrs by BacTiter-Glow assay | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Galanin message-associated peptide suppresses growth and the budded-to-hyphal-form transition of Candida albicans. |
| AID1157154 | Antifungal activity against Candida albicans PMC 1011 after 48 hrs by CLSI broth microdilution method | 2014 | European journal of medicinal chemistry, Aug-18, Volume: 83 | Synthesis, biological evaluation and structure-activity correlation study of a series of imidazol-based compounds as Candida albicans inhibitors. |
| AID518166 | Antimicrobial activity against Cryptococcus gattii serotype C isolate H0058-1-2086 assessed as concentration required for heteroresistance | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Heteroresistance of Cryptococcus gattii to fluconazole. |
| AID535906 | Antifungal activity against Saccharomyces cerevisiae ATCC 9763 after 24 hrs by broth microdilution method | 2010 | European journal of medicinal chemistry, Nov, Volume: 45, Issue:11 | Synthesis and pharmacological evaluation of clubbed isopropylthiazole derived triazolothiadiazoles, triazolothiadiazines and mannich bases as potential antimicrobial and antitubercular agents. |
| AID1762155 | Antifungal activity against Candida albicans CBS 8837 assessed as reduction in fungal growth incubated for 48 hrs by CLSI based serial microbroth dilution method | 2021 | Bioorganic & medicinal chemistry letters, 05-15, Volume: 40 | Synthesis and antifungal activity of new hybrids thiazolo[4,5-d]pyrimidines with (1H-1,2,4)triazole. |
| AID50296 | Minimum inhibitory concentration of compound for antifungal activity against Candida krusei | 2000 | Bioorganic & medicinal chemistry letters, Oct-02, Volume: 10, Issue:19 | Novel antifungals based on 4-substituted imidazole: a combinatorial chemistry approach to lead discovery and optimization. |
| AID410998 | Antifungal activity against Candida tropicalis DSM 1346 after 24 hrs by broth macrodilution method | 2009 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 19, Issue:1 | One-pot synthesis of 5-phenylimino, 5-thieno or 5-oxo-1,2,3-dithiazoles and evaluation of their antimicrobial and antitumor activity. |
| AID1185706 | Antimicrobial activity against Candida albicans ATCC 60193 after 24 hrs by agar dilution method | 2014 | European journal of medicinal chemistry, Sep-12, Volume: 84 | New thiophene-1,2,4-triazole-5(3)-ones: highly bioactive thiosemicarbazides, structures of Schiff bases and triazole-thiols. |
| AID279704 | Antifungal activity against planktonic Candida albicans K1 in presence of biofilm material after 48 hrs by CLSI M27 A micro-broth method | 2007 | Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2 | Putative role of beta-1,3 glucans in Candida albicans biofilm resistance. |
| AID1918371 | Antifungal activity against Candida albicans infected in mouse assessed as reduction in fungal endogenous infection symptoms at 20 mg/kg, ip administered on days 2,4,6,8,10,12 and measured on day 14 by hematoxylin-eosin staining based analysis | 2022 | Journal of medicinal chemistry, 11-10, Volume: 65, Issue:21 | Novel Aryl Alkamidazole Derivatives as Multifunctional Antifungal Inhibitors: Design, Synthesis, and Biological Evaluation. |
| AID197814 | In vitro evaluation of minimum inhibitory concentration against Rhodotorula rubra 16 | 1995 | Journal of medicinal chemistry, Sep-29, Volume: 38, Issue:20 | Synthesis and antifungal activity of new azole derivatives containing an N-acylmorpholine ring. |
| AID1430051 | Anti-fungal activity against Candida albicans after 48 hrs by broth microdilution method | |||
| AID1600163 | Antifungal activity against azole-susceptible Candida parapsilosis ATCC 90018 assessed as reduction in fungal growth incubated for 48 hrs by broth microdilution method | 2019 | European journal of medicinal chemistry, Oct-01, Volume: 179 | Discovery of new azoles with potent activity against Candida spp. and Candida albicans biofilms through virtual screening. |
| AID294854 | Antifungal activity against Fonsecaea compacta after 7 days by micro-broth dilution method | 2007 | European journal of medicinal chemistry, Sep, Volume: 42, Issue:9 | Synthesis of novel triazole derivatives as inhibitors of cytochrome P450 14alpha-demethylase (CYP51). |
| AID1157292 | Antifungal activity against Candida parapsilosis 22019 assessed as growth inhibition by automatic microplate reader analysis | 2014 | Journal of natural products, May-23, Volume: 77, Issue:5 | Polyhydroxy cyclohexanols from a Dendrodochium sp. fungus associated with the sea cucumber Holothuria nobilis Selenka. |
| AID424646 | Antimicrobial activity against azole-resistant Candida albicans isolate CA10 assessed as growth at 32 ug/ml co-treated with 0.125 ug/ml calcineurin signaling inhibitor tacrolimus after 48 hrs by microdilution checkboard technique relative to control | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | In vitro interactions between tacrolimus and azoles against Candida albicans determined by different methods. |
| AID285854 | Antimicrobial susceptibility of Pichia anomala from nosocomial fungemia patient assessed as percent susceptible isolates at 0.06 ug/ml by CLSI method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Antifungal drug susceptibility profile of Pichia anomala isolates from patients presenting with nosocomial fungemia. |
| AID405012 | Antifungal activity against Sporothrix schenckii PSSA81 isolate from cutaneous-lymphatic sporotrichosis patient after 72 hrs by modified NCCLS M38-A method | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | In vitro susceptibility of Sporothrix schenckii to six antifungal agents determined using three different methods. |
| AID554712 | Antimicrobial activity against Candida krusei IFO0011 after 48 hrs by CLSI method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Abc1p is a multidrug efflux transporter that tips the balance in favor of innate azole resistance in Candida krusei. |
| AID549028 | Antimicrobial activity against Candida krusei LMR 39-14 infected in immunosuppressed CF-1 mouse assessed as serum 1,3-beta-D-glucan level at 40 mg/kg, ip administered once daily for 5 days measured after 10 days (Rvb= 5.22) | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Activity of anidulafungin in a murine model of Candida krusei infection: evaluation of mortality and disease burden by quantitative tissue cultures and measurement of serum (1,3)-beta-D-glucan levels. |
| AID434360 | Antifungal activity against Candida albicans after 48 hrs by broth microdilution method | 2009 | European journal of medicinal chemistry, Aug, Volume: 44, Issue:8 | Design, synthesis and biological evaluation of novel nitrogen and sulfur containing hetero-1,4-naphthoquinones as potent antifungal and antibacterial agents. |
| AID1063944 | Antifungal activity against Trichophyton mentagrophytes 445 after 72 hrs by broth microdilution method | 2014 | Bioorganic & medicinal chemistry, Jan-15, Volume: 22, Issue:2 | Salicylanilide diethyl phosphates: synthesis, antimicrobial activity and cytotoxicity. |
| AID1413334 | Antifungal activity against Candida albicans 94-2181 | 2018 | MedChemComm, Jun-01, Volume: 9, Issue:6 | Antifungal amphiphilic kanamycins: new life for an old drug. |
| AID1265644 | Antifungal activity against Candida parapsilosis clinical isolate after 24 hrs by sabouraud dextrose broth based microdilution method | 2016 | European journal of medicinal chemistry, Jan-01, Volume: 107 | Anti-Candida activity and cytotoxicity of a large library of new N-substituted-1,3-thiazolidin-4-one derivatives. |
| AID1446480 | Antifungal activity against Cryptococcus neoformans ATCC 350 after 70 to 74 hrs by alamar blue dye based CLSI method | 2017 | Journal of medicinal chemistry, 08-10, Volume: 60, Issue:15 | Discovery of a Membrane-Active, Ring-Modified Histidine Containing Ultrashort Amphiphilic Peptide That Exhibits Potent Inhibition of Cryptococcus neoformans. |
| AID642916 | Antifungal activity against Candida parapsilosis ATCC 22019 | 2011 | ACS medicinal chemistry letters, May-12, Volume: 2, Issue:5 | Natural Product Based 6-Hydroxy-2,3,4,6-tetrahydropyrrolo[1,2-a]pyrimidinium Scaffold as A New Antifungal Template. |
| AID1905286 | Anti biofilm activity in Candida albicans 904 assessed as downregulation of EFG1 at 32 ug/ml incubated for 24 hrs by RT-PCR analysis | 2022 | Journal of medicinal chemistry, 04-14, Volume: 65, Issue:7 | Species-Selective Targeting of Fungal Hsp90: Design, Synthesis, and Evaluation of Novel 4,5-Diarylisoxazole Derivatives for the Combination Treatment of Azole-Resistant Candidiasis. |
| AID1877309 | Fungicidal activity against Candida albicans CPCC400616 assessed as minimum inhibitory concentration incubated for 48 hrs | 2022 | European journal of medicinal chemistry, Jan-05, Volume: 227 | Broadening antifungal spectrum and improving metabolic stablity based on a scaffold strategy: Design, synthesis, and evaluation of novel 4-phenyl-4,5-dihydrooxazole derivatives as potent fungistatic and fungicidal reagents. |
| AID537736 | Antifungal activity against yeast AD1-8u expressing Candida albicans CaCdr1p by agar disk diffusion assay | 2010 | European journal of medicinal chemistry, Nov, Volume: 45, Issue:11 | Analysis of physico-chemical properties of substrates of ABC and MFS multidrug transporters of pathogenic Candida albicans. |
| AID1628386 | Antimicrobial activity against Staphylococcus aureus ATCC 25923 incubated for 24 hrs by NCCLS protocol based method | 2016 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 26, Issue:12 | Discovery of novel berberine imidazoles as safe antimicrobial agents by down regulating ROS generation. |
| AID685358 | Antifungal activity against Candida albicans after 48 hrs by broth microdilution method | 2012 | European journal of medicinal chemistry, Oct, Volume: 56 | Micelles catalyzed chemo- and regio-selective one pot and one step synthesis of 2,3,5,6-tetrakis(alkyl and arylsulfanyl)-1,4-benzoquinones and 2,5-diaminosubstituted-1,4-benzoquinones "In-Water" and their biological evaluation as antibacterial and antifun |
| AID372231 | Effect on CDR4 RNA level in Candida albicans SSK21 at MIC after 120 mins by RT-PCR | 2007 | Antimicrobial agents and chemotherapy, Oct, Volume: 51, Issue:10 | The Ssk1p response regulator and Chk1p histidine kinase mutants of Candida albicans are hypersensitive to fluconazole and voriconazole. |
| AID486967 | Antifungal activity against Aspergillus fumigatus after 72 hrs by micro broth dilution method | 2010 | European journal of medicinal chemistry, Jun, Volume: 45, Issue:6 | 'On water' assisted synthesis and biological evaluation of nitrogen and sulfur containing hetero-1,4-naphthoquinones as potent antifungal and antibacterial agents. |
| AID1191520 | Antibacterial activity against Trichosporon asahii 1188 after 48 hrs by broth microdilution method | 2015 | Bioorganic & medicinal chemistry, Feb-15, Volume: 23, Issue:4 | Synthesis and in vitro biological evaluation of 2-(phenylcarbamoyl)phenyl 4-substituted benzoates. |
| AID555821 | Ratio of MIC50 for Candida albicans 5674 to MIC50 for cdr1/cdr1 deficient Candida albicans STY19 | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Relative contributions of the Candida albicans ABC transporters Cdr1p and Cdr2p to clinical azole resistance. |
| AID1601661 | Antibiofilm activity against Candida albicans ATCC 10231 assessed as inhibition of biofilm formation by XTT reduction assay | |||
| AID638562 | Antifungal activity against Candida albicans Berkout KCCM 50235 after 1 day by standard two fold broth dilution method | 2012 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 22, Issue:1 | Synthesis and antifungal evaluation of pyrido[1,2-a]indole-1,4-diones and benzo[f]pyrido[1,2-a]indole-6,11-diones. |
| AID1818274 | Antifungal activity against Candida albicans strain 17 assessed as reduction in fungal growth incubated for 72 hrs by CLSI protocol based broth microdilution method | |||
| AID48935 | Tested for in vitro antifungal activity against Candida albicans TIMM3164 | 2002 | Bioorganic & medicinal chemistry letters, Jul-08, Volume: 12, Issue:13 | Synthesis and evaluation of N-substituted 1,4-oxazepanyl Sordaricins as selective fungal EF-2 inhibitors. |
| AID1905262 | Antifungal activity against fluconazole-resistant Candida albicans 103 assessed as inhibition of fungal growth by checker board microdilution assay | 2022 | Journal of medicinal chemistry, 04-14, Volume: 65, Issue:7 | Species-Selective Targeting of Fungal Hsp90: Design, Synthesis, and Evaluation of Novel 4,5-Diarylisoxazole Derivatives for the Combination Treatment of Azole-Resistant Candidiasis. |
| AID566883 | Antifungal activity against Aspergillus fumigates by microdilution test | 2011 | European journal of medicinal chemistry, Jan, Volume: 46, Issue:1 | Synthesis and antifungal activity of some substituted phenothiazines and related compounds. |
| AID174692 | In vivo evaluation of antifungal activity in against vaginal candidosis in rat at dose 0.25 mg/kg on 10th day | 1995 | Journal of medicinal chemistry, Sep-29, Volume: 38, Issue:20 | Synthesis and antifungal activity of new azole derivatives containing an N-acylmorpholine ring. |
| AID19006 | Calculated membrane partition coefficient (Kmemb) | 2004 | Journal of medicinal chemistry, Mar-25, Volume: 47, Issue:7 | Surface activity profiling of drugs applied to the prediction of blood-brain barrier permeability. |
| AID1168340 | Binding affinity to human serum albumin by spectroscopy in presence of Fe3+ | 2014 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 24, Issue:21 | Study the interactions between human serum albumin and two antifungal drugs: fluconazole and its analogue DTP. |
| AID1487224 | Inhibition of CYP17 hydroxylase in human hepatocyte microsomes using pregnenolone substrate by HPLC/MS/MS method | 2017 | Bioorganic & medicinal chemistry letters, 08-01, Volume: 27, Issue:15 | Design and optimization of highly-selective, broad spectrum fungal CYP51 inhibitors. |
| AID704472 | Antifungal activity against Candida tropicalis MY 1012 after 40 hrs by NCCLS broth microdilution method | 2012 | ACS medicinal chemistry letters, Oct-11, Volume: 3, Issue:10 | Antifungal spectrum, in vivo efficacy, and structure-activity relationship of ilicicolin h. |
| AID405101 | Antimicrobial activity against Cunninghamella sp. after 24 hrs | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | In vitro susceptibilities of 217 clinical isolates of zygomycetes to conventional and new antifungal agents. |
| AID1246681 | Antifungal activity against Cryptococcus neoformans WP assessed as reduction in cell viability at 26 uM after 6 to 72 hrs by MTT assay | 2015 | European journal of medicinal chemistry, Sep-18, Volume: 102 | Thiazole compounds with activity against Cryptococcus gattii and Cryptococcus neoformans in vitro. |
| AID603259 | Antifungal activity against Candida albicans ATCC Y0109 after 24 hrs by micro-broth dilution method | 2011 | European journal of medicinal chemistry, Jul, Volume: 46, Issue:7 | Design, synthesis and molecular docking studies of novel triazole as antifungal agent. |
| AID1079940 | Granulomatous liver disease, proven histopathologically. Value is number of references indexed. [column 'GRAN' in source] | |||
| AID594127 | Antifungal activity against Candida albicans ATCC 18804 after 24 hrs | 2011 | European journal of medicinal chemistry, May, Volume: 46, Issue:5 | Pyridine-derived thiosemicarbazones and their tin(IV) complexes with antifungal activity against Candida spp. |
| AID598224 | Antimicrobial activity against Candida albicans isolate 47 after 48 hrs by microdilution broth method | 2011 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 21, Issue:11 | Synthesis and in vitro antimicrobial activities of new (cyano-NNO-azoxy)pyrazole derivatives. |
| AID1911625 | Antifungal activity against Mucor racemosus R715 assessed as fungal growth inhibition by broth microdilution assay | 2022 | Journal of medicinal chemistry, 06-09, Volume: 65, Issue:11 | Development of Lipo-γ-AA Peptides as Potent Antifungal Agents. |
| AID1898166 | Antifungal activity against Candida parapsilosis 660 | |||
| AID1820655 | Stability in human plasma assessed as compound remaining incubated for 120 mins by LC-MS/MS analysis | 2022 | European journal of medicinal chemistry, Jan-15, Volume: 228 | Design, synthesis, and biological activity evaluation of 2-(benzo[b]thiophen-2-yl)-4-phenyl-4,5-dihydrooxazole derivatives as broad-spectrum antifungal agents. |
| AID554936 | Increase in ABC1 mRNA expression in Candida krusei B2399 at MIC concentration after 320 mins by hot-phenol extraction based Northern blotting | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Abc1p is a multidrug efflux transporter that tips the balance in favor of innate azole resistance in Candida krusei. |
| AID565401 | Antifungal activity against Rhizopus microsporus IHEM 9503 by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Correlation of in vitro activity, serum levels, and in vivo efficacy of posaconazole against Rhizopus microsporus in a murine disseminated infection. |
| AID753240 | Antifungal activity against Candida mycoderma after 24 hrs by two-fold serial dilution method | 2013 | European journal of medicinal chemistry, Jun, Volume: 64 | Design, synthesis and antimicrobial evaluation of novel benzimidazole type of Fluconazole analogues and their synergistic effects with Chloromycin, Norfloxacin and Fluconazole. |
| AID1495973 | Inhibition of Trichophyton mentagrophytes keratinase activity at MIC incubated for 5 days under non-shaking condition and subsequent incubation for 5 days under shaking condition by UV-vis spectrophotometric analysis relative to control | 2018 | Bioorganic & medicinal chemistry, 07-23, Volume: 26, Issue:12 | Efficiency of newly prepared thiazole derivatives against some cutaneous fungi. |
| AID1890292 | Inhibition of CYP51 in mouse NIH/3T3 cells assessed as specific enzymatic activity at 25 ug/ml incubated for 48 hrs by ELISA analysis | 2022 | Bioorganic & medicinal chemistry letters, 05-01, Volume: 63 | Novel 2-aryl-4-aryloxyquinoline-based fungistatics for Mucor circinelloides. Biological evaluation of activity, QSAR and docking study. |
| AID457980 | Antifungal activity against Candida albicans ATCC 90028 after 48 hrs by microdilution method | 2010 | Bioorganic & medicinal chemistry, Mar-01, Volume: 18, Issue:5 | Antifungal 3,5-disubstituted furanones: From 5-acyloxymethyl to 5-alkylidene derivatives. |
| AID1557078 | Antifungal activity against Candida glabrata ATCC 66032 assessed as reduction in fungal cell growth incubated for 24 hrs by MTT based broth double dilution method | 2019 | European journal of medicinal chemistry, Oct-01, Volume: 179 | Antifungal activity, mode of action variability, and subcellular distribution of coumarin-based antifungal azoles. |
| AID467907 | Antifungal activity against Aspergillus fumigatus after 48 hrs by broth microdilution technique | 2010 | European journal of medicinal chemistry, Feb, Volume: 45, Issue:2 | Imidazole derivatives as possible microbicides with dual protection. |
| AID549036 | Antimicrobial activity against Candida krusei LMR 39-14 by M27-A3 microdilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Activity of anidulafungin in a murine model of Candida krusei infection: evaluation of mortality and disease burden by quantitative tissue cultures and measurement of serum (1,3)-beta-D-glucan levels. |
| AID1592342 | Antifungal activity against Saccharomyces cerevisiae SH 20 after 72 hrs by agar dilution method | 2019 | European journal of medicinal chemistry, Apr-01, Volume: 167 | Efficient click chemistry towards novel 1H-1,2,3-triazole-tethered 4H-chromene-d-glucose conjugates: Design, synthesis and evaluation of in vitro antibacterial, MRSA and antifungal activities. |
| AID1885978 | Antifungal activity against Cryptococcus neoformans H99 assessed as fungal growth inhibition incubated for 72 hrs in presence of P163-0892 by broth microdilution method | |||
| AID1247372 | Antifungal activity against Cryptococcus neoformans 32609 after 72 hrs by serial dilution method | 2015 | European journal of medicinal chemistry, Sep-18, Volume: 102 | Design, synthesis, and structure-activity relationship studies of novel thienopyrrolidone derivatives with strong antifungal activity against Aspergillus fumigates. |
| AID1595108 | Antifungal activity against Aspergillus niger assessed as reduction in fungal cell growth incubated for 48 hrs by broth microdilution susceptibility method | 2019 | European journal of medicinal chemistry, May-15, Volume: 170 | Tetrazole hybrids and their antifungal activities. |
| AID518661 | Antimicrobial activity against Cryptococcus gattii serotype B isolate NIH771 assessed as heteroresistant isolates at 8 ug/ml | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Heteroresistance of Cryptococcus gattii to fluconazole. |
| AID521791 | Fungistatic activity against Candida glabrata isolate 4205 assessed as 99.9% reduction of initial fungal load at 0.5 times MIC after 48 hrs using colony count method by time-kill method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Posaconazole against Candida glabrata isolates with various susceptibilities to fluconazole. |
| AID1550462 | Antifungal activity against Candida tropicalis IBA 171 assessed as diameter of zone inhibition at 0.025 mg incubated for 24 hrs by disc diffusion method | 2019 | European journal of medicinal chemistry, Jun-01, Volume: 171 | Antimicrobial and KPC/AmpC inhibitory activity of functionalized benzosiloxaboroles. |
| AID565555 | Antifungal activity against Rhizopus microsporus UTHSC 07-371 by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Correlation of in vitro activity, serum levels, and in vivo efficacy of posaconazole against Rhizopus microsporus in a murine disseminated infection. |
| AID405026 | Antifungal activity against Sporothrix schenckii P14954 isolate from cutaneous-lymphatic sporotrichosis patient after 72 hrs by ATB Fungus 2 method | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | In vitro susceptibility of Sporothrix schenckii to six antifungal agents determined using three different methods. |
| AID1898157 | Antifungal activity against Trichophyton rubrum cmccftla | |||
| AID1820654 | Stability in human plasma assessed as compound remaining incubated for 60 mins by LC-MS/MS analysis | 2022 | European journal of medicinal chemistry, Jan-15, Volume: 228 | Design, synthesis, and biological activity evaluation of 2-(benzo[b]thiophen-2-yl)-4-phenyl-4,5-dihydrooxazole derivatives as broad-spectrum antifungal agents. |
| AID775731 | Antifungal activity against Candida albicans assessed as growth inhibition after 48 to 72 hrs by broth microdilution method | 2013 | European journal of medicinal chemistry, Nov, Volume: 69 | Microwave assisted synthesis of dihydrobenzo[4,5]imidazo[1,2-a]pyrimidin-4-ones; synthesis, in vitro antimicrobial and anticancer activities of novel coumarin substituted dihydrobenzo[4,5]imidazo[1,2-a]pyrimidin-4-ones. |
| AID518436 | Antimicrobial activity against Cryptococcus gattii serotype B isolate NIH189 assessed as heteroresistant isolates at 4 ug/ml | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Heteroresistance of Cryptococcus gattii to fluconazole. |
| AID39704 | In vitro evaluation of minimum inhibitory concentration against Aspergillus fumigatus 33 | 1995 | Journal of medicinal chemistry, Sep-29, Volume: 38, Issue:20 | Synthesis and antifungal activity of new azole derivatives containing an N-acylmorpholine ring. |
| AID1904390 | Fungicidal activity against Candida albicans CPCC400616 measured after 48 hrs | 2022 | European journal of medicinal chemistry, Apr-05, Volume: 233 | Design, synthesis, and evaluation of novel 3-thiophene derivatives as potent fungistatic and fungicidal reagents based on a conformational restriction strategy. |
| AID584394 | Antifungal activity against 8 days cultured Candida krusei isolated from neutropenic subject with AML or MDS pharynx after 12 days of prophylaxis by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Impact of antifungal prophylaxis on colonization and azole susceptibility of Candida species. |
| AID462240 | Antifungal activity against Candida albicans SA40 infected in Wistar rat estrogen-dependent fungal vaginitis model assessed as fungal burden at 10 ug administered intravaginally 48 hrs after fungal infection measured on day 5 after infection | 2010 | Journal of medicinal chemistry, Mar-25, Volume: 53, Issue:6 | Identification of inhibitors of drug-resistant Candida albicans strains from a library of bicyclic peptidomimetic compounds. |
| AID665070 | Antifungal activity against Cryptococcus neoformans after 72 hrs by serial dilution method | 2012 | European journal of medicinal chemistry, Jul, Volume: 53 | Design, synthesis and structure-activity relationships of new triazole derivatives containing N-substituted phenoxypropylamino side chains. |
| AID745596 | Antifungal activity against Candida albicans ATCC 10231 assessed as growth inhibition after 18 hrs by CLSI microdilution method | 2013 | Journal of natural products, May-24, Volume: 76, Issue:5 | Antifungal agents from Pseudallescheria boydii SNB-CN73 isolated from a Nasutitermes sp. termite. |
| AID1877873 | Cytotoxicity against PBMC (unknown origin) by MTT assay | 2022 | Bioorganic & medicinal chemistry letters, 02-15, Volume: 58 | Synthesis and antifungal evaluation of phenol-derived bis(indolyl)methanes combined with FLC against Candida albicans. |
| AID516276 | Antimicrobial activity against Cryptococcus gattii serotype B isolate RB-9 assessed as concentration required for heteroresistance | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Heteroresistance of Cryptococcus gattii to fluconazole. |
| AID528079 | Antifungal activity against Candida albicans by broth microdilution method | 2010 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 20, Issue:22 | Stereocontrolled facile synthesis and antimicrobial activity of oximes and oxime ethers of diversely substituted bispidines. |
| AID1898217 | Antifungal activity against Cryptococcus neoformans H99 infected in ICR mouse assessed as median survival time at 2 mg/kg, po qd infected with fungus for 2 hrs prior to compound addition for 7 days and measured for 20 days | |||
| AID619594 | Antifungal activity against Candida glabrata after 24 hrs by broth microdilution method | 2011 | Bioorganic & medicinal chemistry, Oct-01, Volume: 19, Issue:19 | Antifungal activity of a series of 1,2-benzisothiazol-3(2H)-one derivatives. |
| AID1495959 | Antifungal activity against Candida albicans after 48 hrs by broth microdilution method | 2018 | Bioorganic & medicinal chemistry, 07-23, Volume: 26, Issue:12 | Efficiency of newly prepared thiazole derivatives against some cutaneous fungi. |
| AID425148 | Antimicrobial activity against azole-resistant Candida albicans isolate CA10 assessed as growth at 0.063 ug/ml after 48 hrs by microdilution checkerboard technique relative to control | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | In vitro interactions between tacrolimus and azoles against Candida albicans determined by different methods. |
| AID1415630 | Antifungal activity against fluconazole-resistant Candida tropicalis clinical isolate 087 assessed as fungus with permeabilized membrane at 2 ug/ml after 12 hrs by propidium iodide staining-based flow cytometry (Rvb = 7.22%) | 2017 | MedChemComm, May-01, Volume: 8, Issue:5 | Synthesis and synergistic antifungal effects of monoketone derivatives of curcumin against fluconazole-resistant |
| AID527137 | Antifungal activity against Trichophyton rubrum LMGO 08 after 5 days microdilution technique | 2010 | Journal of natural products, Oct-22, Volume: 73, Issue:10 | Search for antifungal compounds from the wood of durable tropical trees. |
| AID531248 | Antifungal activity against Candida glabrata assessed as resistant isolates after 48 hrs by CLSI method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | In vitro susceptibilities of invasive isolates of Candida species: rapid increase in rates of fluconazole susceptible-dose dependent Candida glabrata isolates. |
| AID625276 | FDA Liver Toxicity Knowledge Base Benchmark Dataset (LTKB-BD) drugs of most concern for DILI | 2011 | Drug discovery today, Aug, Volume: 16, Issue:15-16 | FDA-approved drug labeling for the study of drug-induced liver injury. |
| AID1409903 | Antifungal activity against Aspergillus fumigatus after 24 hrs by two-fold serial dilution method | |||
| AID545274 | Antifungal activity against Trichosporon beigelii 1188 after 24 hrs by broth microdilution method | 2010 | European journal of medicinal chemistry, Dec, Volume: 45, Issue:12 | New amino acid esters of salicylanilides active against MDR-TB and other microbes. |
| AID285695 | Serum trough levels in Wistar rat pup at 10 mg/kg of body weight/day, ip after 48 hrs by ELISA | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Neonatal coinfection model of coagulase-negative Staphylococcus (Staphylococcus epidermidis) and Candida albicans: fluconazole prophylaxis enhances survival and growth. |
| AID1187440 | Antifungal activity against Cryptococcus neoformans after 72 hrs by serial dilution method | 2014 | Bioorganic & medicinal chemistry letters, Sep-01, Volume: 24, Issue:17 | Scaffold hopping of sampangine: discovery of potent antifungal lead compound against Aspergillus fumigatus and Cryptococcus neoformans. |
| AID279091 | Ratio of AUC in candidemia patient to MIC against Candida albicans | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Association of fluconazole area under the concentration-time curve/MIC and dose/MIC ratios with mortality in nonneutropenic patients with candidemia. |
| AID757547 | Anticandida activity against Candida parapsilosis clinical isolate assessed as growth inhibition after 24 hrs by broth microdilution method | 2013 | European journal of medicinal chemistry, Jul, Volume: 65 | Synthesis and cytotoxicity of novel (thiazol-2-yl)hydrazine derivatives as promising anti-Candida agents. |
| AID1667449 | Antifungal activity against Candida albicans assessed as zone of inhibition at 25 to 100 ug/ml | 2020 | Bioorganic & medicinal chemistry, 04-01, Volume: 28, Issue:7 | Promising antifungal agents: A minireview. |
| AID1689833 | Inhibition of sterol biosynthesis in Candida albicans CAAL93 assessed as 14alpha-methylfecosterol level at 10 ng/ml after 18 hrs by GC-MS analysis relative to control | 2020 | European journal of medicinal chemistry, Mar-01, Volume: 189 | New azole antifungals with a fused triazinone scaffold. |
| AID516273 | Antimicrobial activity against Cryptococcus gattii serotype B isolate RB-3 assessed as concentration required for heteroresistance | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Heteroresistance of Cryptococcus gattii to fluconazole. |
| AID1334855 | Inhibition of Candida albicans SC5314 CYP51 assessed as obtusifoliol composition of total sterols at 8 ug/ml by GC-MS method relative to control | 2017 | Bioorganic & medicinal chemistry, 01-15, Volume: 25, Issue:2 | Discovery of biphenyl imidazole derivatives as potent antifungal agents: Design, synthesis, and structure-activity relationship studies. |
| AID1495972 | Inhibition of Microsporum gypseum keratinase activity at MIC incubated for 5 days under non-shaking condition and subsequent incubation for 5 days under shaking condition by UV-vis spectrophotometric analysis relative to control | 2018 | Bioorganic & medicinal chemistry, 07-23, Volume: 26, Issue:12 | Efficiency of newly prepared thiazole derivatives against some cutaneous fungi. |
| AID47887 | Evaluation of In vitro antifungal activity against Candida parapsilosis ATCC 141095 by broth macro dilution method | 1995 | Journal of medicinal chemistry, Sep-29, Volume: 38, Issue:20 | Synthesis and antifungal activity of new azole derivatives containing an N-acylmorpholine ring. |
| AID581882 | Antifungal activity against Candida glabrata isolated from HSCT recipient 975 with acute or chronic GVHD mouth after 112 days prophylaxis by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Impact of antifungal prophylaxis on colonization and azole susceptibility of Candida species. |
| AID269985 | Antifungal activity against Candida krusei 603 | 2006 | Journal of medicinal chemistry, Aug-10, Volume: 49, Issue:16 | Synthesis and antifungal activity of a novel series of alkyldimethylamine cyanoboranes and their derivatives. |
| AID518455 | Antimicrobial activity against Cryptococcus gattii serotype C isolate NIH113 assessed as heteroresistant isolates at 4 ug/ml | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Heteroresistance of Cryptococcus gattii to fluconazole. |
| AID1370739 | Antifungal activity against Cryptococcus neoformans after 72 hrs by serial dilution method | 2018 | Bioorganic & medicinal chemistry letters, 02-01, Volume: 28, Issue:3 | Design, synthesis, and structure-activity relationship studies of novel tetrazole antifungal agents with potent activity, broad antifungal spectrum and high selectivity. |
| AID1413586 | Inhibition of CYP51 in Candida albicans SC5314 assessed as unidentified sterol content at 8 ug/ml after 16 hrs by GC/MS analysis (Rvb = 5.8%) | |||
| AID581898 | Antifungal activity against Candida glabrata isolated from HSCT recipient 002 with acute or chronic GVHD mouth after 116 days prophylaxis by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Impact of antifungal prophylaxis on colonization and azole susceptibility of Candida species. |
| AID1658339 | Antifungal activity against fluconazole-resistant Candida albicans CaR assessed as reduction in fungal growth by NCCLS method | 2020 | ACS medicinal chemistry letters, Jun-11, Volume: 11, Issue:6 | Construction and Evaluation of Molecular Models: Guide and Design of Novel SE Inhibitors. |
| AID719026 | Antifungal activity against Trichophyton mentagrophytes 445 assessed as growth inhibition after 120 hrs by CLSI M38-A broth microdilution method | 2012 | Bioorganic & medicinal chemistry, Dec-15, Volume: 20, Issue:24 | Anti-infective and herbicidal activity of N-substituted 2-aminobenzothiazoles. |
| AID419080 | Antifungal activity against Candida parapsilosis ATCC 90018 | 2009 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 19, Issue:7 | Amide analogs of antifungal dioxane-triazole derivatives: synthesis and in vitro activities. |
| AID522130 | Antimicrobial activity against Candida glabrata TG162 containing calcineurin deltacnb1 mutant by colorimetric microdilution method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Roles of calcineurin and Crz1 in antifungal susceptibility and virulence of Candida glabrata. |
| AID440352 | Antifungal activity against Candida albicans NCIM 300 after 2 to 3 days by serial plate dilution method | 2009 | European journal of medicinal chemistry, Dec, Volume: 44, Issue:12 | Synthesis and antimicrobial activity of some new N-acyl substituted phenothiazines. |
| AID440340 | Antifungal activity against Aspergillus flavus NCIM 524 after 2 to 3 days by serial plate dilution method | 2009 | European journal of medicinal chemistry, Dec, Volume: 44, Issue:12 | Synthesis and antimicrobial activity of some new N-acyl substituted phenothiazines. |
| AID1168337 | Binding affinity to human serum albumin by spectroscopy in presence of Cu2+ | 2014 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 24, Issue:21 | Study the interactions between human serum albumin and two antifungal drugs: fluconazole and its analogue DTP. |
| AID1472860 | Solubility of the compound in DMSO | 2018 | Journal of medicinal chemistry, 01-11, Volume: 61, Issue:1 | Alkylated Piperazines and Piperazine-Azole Hybrids as Antifungal Agents. |
| AID434361 | Antifungal activity against Cryptococcus neoformans after 72 hrs by broth microdilution method | 2009 | European journal of medicinal chemistry, Aug, Volume: 44, Issue:8 | Design, synthesis and biological evaluation of novel nitrogen and sulfur containing hetero-1,4-naphthoquinones as potent antifungal and antibacterial agents. |
| AID1157173 | Antifungal activity against Trichophyton mentagrophytes PMC 6531 after 72 hrs by CLSI broth microdilution method | 2014 | European journal of medicinal chemistry, Aug-18, Volume: 83 | Synthesis, biological evaluation and structure-activity correlation study of a series of imidazol-based compounds as Candida albicans inhibitors. |
| AID518144 | Antimicrobial activity against Cryptococcus gattii serotype B isolate RAM-005 assessed as concentration required for heteroresistance | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Heteroresistance of Cryptococcus gattii to fluconazole. |
| AID1061740 | Antimicrobial activity against Cryptococcus neoformans after 72 hrs by broth microdilution method | 2014 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 24, Issue:1 | Synthesis and evaluation of novel azoles as potent antifungal agents. |
| AID1918373 | Antifungal activity against Candida albicans infected in mouse assessed as reduction in total amount of fungal cells in infection region at 20 mg/kg, ip administered on days 2,4,6,8,10,12 and measured on day 14 by hematoxyin-eosin staining based analysis | 2022 | Journal of medicinal chemistry, 11-10, Volume: 65, Issue:21 | Novel Aryl Alkamidazole Derivatives as Multifunctional Antifungal Inhibitors: Design, Synthesis, and Biological Evaluation. |
| AID279096 | Ratio of weight normalized daily dose in candidemia patient to MIC against Candida albicans | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Association of fluconazole area under the concentration-time curve/MIC and dose/MIC ratios with mortality in nonneutropenic patients with candidemia. |
| AID1864903 | Antifungal activity against fluconazole- resistant Candida albicans 901 assessed as fungal growth inhibition measured after 72 hrs in presence of naproxen by double dilution method | |||
| AID555001 | Antifungal activity against Candida krusei assessed as percent susceptible isolates at 25 ug/disc by CLSI M44-A disk diffusion method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | In vitro activities of fluconazole and voriconazole against clinical isolates of Candida spp. determined by disk diffusion testing in Turin, Italy. |
| AID1329226 | Inhibition of CDR1/CDR2 in Candida albicans clinical isolate 147 assessed as potentiation of fluconazole-induced antifungal activity by measuring fluconazole MIC80 up to 8 ug/ml after 24 hrs by XTT based broth microdilution assay (Rvb = >128 ug/ml) | 2016 | Journal of natural products, 09-23, Volume: 79, Issue:9 | Heptaketides from an Endolichenic Fungus Biatriospora sp. and Their Antifungal Activity. |
| AID367165 | Cytotoxicity against human Hep3B cells at 0.001 mg/ml | 2009 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 19, Issue:3 | Synthesis and antifungal activity of 1,2,3-triazole containing fluconazole analogues. |
| AID1480831 | Anti-fungal activity against Candida albicans ATCC 90028 after 48 hrs by broth microdilution method | 2017 | European journal of medicinal chemistry, Apr-21, Volume: 130 | New azole derivatives showing antimicrobial effects and their mechanism of antifungal activity by molecular modeling studies. |
| AID459754 | Antifungal activity against Cryptococcus neoformans by serial dilution method | 2010 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 20, Issue:3 | Synthesis and antifungal activities in vitro of novel pyrazino [2,1-a] isoquinolin derivatives. |
| AID542087 | Antifungal activity against Candida tropicalis ATCC 200956 after 24 hrs by microdilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Discovery of a small-molecule inhibitor of {beta}-1,6-glucan synthesis. |
| AID1329225 | Inhibition of CDR1/CDR2 in Candida albicans clinical isolate 145 assessed as potentiation of fluconazole-induced antifungal activity by measuring fluconazole MIC80 up to 8 ug/ml after 24 hrs by XTT based broth microdilution assay (Rvb = >128 ug/ml) | 2016 | Journal of natural products, 09-23, Volume: 79, Issue:9 | Heptaketides from an Endolichenic Fungus Biatriospora sp. and Their Antifungal Activity. |
| AID1762148 | Antifungal activity against Candida parapsilosis ATCC 22019 assessed as reduction in fungal growth incubated for 24 hrs by CLSI based serial microbroth dilution method | 2021 | Bioorganic & medicinal chemistry letters, 05-15, Volume: 40 | Synthesis and antifungal activity of new hybrids thiazolo[4,5-d]pyrimidines with (1H-1,2,4)triazole. |
| AID372248 | Fungicidal activity against Candida albicans SSK21 assessed as reduction in cell viability at 4 times MIC after 24 hrs | 2007 | Antimicrobial agents and chemotherapy, Oct, Volume: 51, Issue:10 | The Ssk1p response regulator and Chk1p histidine kinase mutants of Candida albicans are hypersensitive to fluconazole and voriconazole. |
| AID518159 | Antimicrobial activity against Cryptococcus gattii serotype C isolate NIH401 assessed as concentration required for heteroresistance | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Heteroresistance of Cryptococcus gattii to fluconazole. |
| AID43439 | Effect of increase in enzyme concentration by 10 times on the inhibition of beta-lactamase by the compound:No inhibition | 2003 | Journal of medicinal chemistry, Oct-09, Volume: 46, Issue:21 | Identification and prediction of promiscuous aggregating inhibitors among known drugs. |
| AID392361 | Antifungal activity against Candida tropicalis ATCC 156 after 24 hrs by broth microdilution method | 2009 | Bioorganic & medicinal chemistry letters, Jan-15, Volume: 19, Issue:2 | Salicylanilide esters of N-protected amino acids as novel antimicrobial agents. |
| AID554719 | Antimicrobial activity against Saccharomyces cerevisiae isolate ADdelta overexpressing Candida albicans ERG11A after 48 hrs by liquid microdilution assay | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Abc1p is a multidrug efflux transporter that tips the balance in favor of innate azole resistance in Candida krusei. |
| AID521978 | Antibacterial activity against Fluconazole resistant Candida albicans DSY296 overexpressing multidrug transporter gene CDR1 and CDR2 and containing ERG11 G464S mutation containing CIp10 to restore URA3 function infected in BALB/c mouse administered intrap | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Genetic dissection of azole resistance mechanisms in Candida albicans and their validation in a mouse model of disseminated infection. |
| AID1201585 | Antifungal activity against Chrysosporium keratinophilum at 0.5 mg/ml incubated for 3 days | 2015 | European journal of medicinal chemistry, May-05, Volume: 95 | Synthesis and biological evaluation of new imidazo[2,1-b][1,3,4]thiadiazole-benzimidazole derivatives. |
| AID42698 | Concentration required to reduce the growth of Candida albicans to 50% of that in the control | 2000 | Journal of medicinal chemistry, Jun-29, Volume: 43, Issue:13 | A three-dimensional model of lanosterol 14alpha-demethylase of Candida albicans and its interaction with azole antifungals. |
| AID406863 | Antimicrobial activity against Candida albicans GDH2346 at planktonic cell density of 10'8 cells/ml after 48 hrs by XTT assay | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | Role for cell density in antifungal drug resistance in Candida albicans biofilms. |
| AID540209 | Volume of distribution at steady state in human after iv administration | 2008 | Drug metabolism and disposition: the biological fate of chemicals, Jul, Volume: 36, Issue:7 | Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. |
| AID581871 | Antifungal activity against Candida glabrata isolated from neutropenic subject 1318 with AML or MDS stool receiving antifungal drug after 36 days prophylaxis by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Impact of antifungal prophylaxis on colonization and azole susceptibility of Candida species. |
| AID1246590 | Antifungal activity against Cryptococcus neoformans 96806 after 48 to 72 hrs by broth microdilution method | 2015 | European journal of medicinal chemistry, Sep-18, Volume: 102 | Thiazole compounds with activity against Cryptococcus gattii and Cryptococcus neoformans in vitro. |
| AID1309053 | Antifungal activity against Candida glabrata ATCC 2001 after 48 hrs by CLSI M27-A3 method | 2016 | Bioorganic & medicinal chemistry, 08-15, Volume: 24, Issue:16 | Synthesis and investigation of novel benzimidazole derivatives as antifungal agents. |
| AID672344 | Antifungal activity against Candida krusei KCCM 11655 after 1 day | 2012 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 22, Issue:15 | Synthesis, antitubercular and antimicrobial evaluation of 3-(4-chlorophenyl)-4-substituted pyrazole derivatives. |
| AID1287615 | Antifungal activity against Aspergillus fumigatus clinical isolate after 18 to 24 hrs by micro-dilution method | 2016 | European journal of medicinal chemistry, May-04, Volume: 113 | Synthesis of newer 1,2,3-triazole linked chalcone and flavone hybrid compounds and evaluation of their antimicrobial and cytotoxic activities. |
| AID1877296 | Inhibition of CYP51 in Candida albicans SC3514 assessed as decrease in ergosterol biosynthesis by measuring ergosterol level at 0.25 ug/ml incubated for 16 hrs by GC-MS analysis (Rvb = 96.93%) | 2022 | European journal of medicinal chemistry, Jan-05, Volume: 227 | Broadening antifungal spectrum and improving metabolic stablity based on a scaffold strategy: Design, synthesis, and evaluation of novel 4-phenyl-4,5-dihydrooxazole derivatives as potent fungistatic and fungicidal reagents. |
| AID522122 | Antimicrobial activity against Candida glabrata TG172 containing deltacrz1 mutant assessed as reduction in bacterial cell viability by time kill study | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Roles of calcineurin and Crz1 in antifungal susceptibility and virulence of Candida glabrata. |
| AID257108 | Antifungal activity against Candida albicans | 2005 | Journal of medicinal chemistry, Dec-01, Volume: 48, Issue:24 | Design, synthesis, and microbiological evaluation of new Candida albicans CYP51 inhibitors. |
| AID609971 | Antifungal activity against Aspergillus flavus at 500 ug after 24 hrs by paper disc technique relative to control | 2011 | Bioorganic & medicinal chemistry letters, Aug-15, Volume: 21, Issue:16 | Efficient synthesis of antifungal active 9-substituted-3-aryl-5H,13aH-quinolino[3,2-f][1,2,4]triazolo[4,3-b][1,2,4]triazepines in ionic liquids. |
| AID1254076 | Antifungal activity against Candida albicans 7535 by two-fold serial dilution method | 2015 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 25, Issue:22 | Synthesis and biological evaluation of 1,3-diaryl pyrazole derivatives as potential antibacterial and anti-inflammatory agents. |
| AID1601667 | Antibiofilm activity against Candida albicans PMC 1082 assessed as inhibition of biofilm formation by XTT reduction assay | |||
| AID262551 | Antifungal activity against Fonsecaea pedrosoi | 2006 | Journal of medicinal chemistry, Apr-20, Volume: 49, Issue:8 | Structure-based optimization of azole antifungal agents by CoMFA, CoMSIA, and molecular docking. |
| AID750285 | Antifungal activity against Candida krusei ATCC 6258 after 24 to 48 hrs by broth microdilution method | 2013 | European journal of medicinal chemistry, Jun, Volume: 64 | 2-Aminobenzothiazole derivatives: search for new antifungal agents. |
| AID405057 | Antifungal activity against Sporothrix schenckii P14036 isolate from cutaneous-lymphatic sporotrichosis patient after 72 hrs by modified NCCLS M38-A method | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | In vitro susceptibility of Sporothrix schenckii to six antifungal agents determined using three different methods. |
| AID545152 | Antimicrobial activity against Candida albicans isolate R after 48 hrs by microdilution method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Breakthrough Aspergillus fumigatus and Candida albicans double infection during caspofungin treatment: laboratory characteristics and implication for susceptibility testing. |
| AID581887 | Antifungal activity against Saccharomyces cerevisiae isolated from HSCT recipient 513 with acute or chronic GVHD mouth receiving antifungal drug after 112 days prophylaxis by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Impact of antifungal prophylaxis on colonization and azole susceptibility of Candida species. |
| AID1695824 | Antifungal activity against Aspergillus brasiliensis ATCC 16404 incubated for 24 hrs by microdilution method | 2019 | European journal of medicinal chemistry, Apr-15, Volume: 168 | Comprehensive review on the anti-bacterial activity of 1,2,3-triazole hybrids. |
| AID302117 | Antifungal activity against Cryptococcus neoformans after 72 hrs | 2007 | Journal of medicinal chemistry, Nov-01, Volume: 50, Issue:22 | Synthesis and antifungal activities of novel 2-aminotetralin derivatives. |
| AID287822 | Antifungal activity against Candida tropicalis 156 after 48 hrs | 2007 | Bioorganic & medicinal chemistry, Apr-15, Volume: 15, Issue:8 | Hybrid molecules of estrone: new compounds with potential antibacterial, antifungal, and antiproliferative activities. |
| AID554721 | Antimicrobial activity against Saccharomyces cerevisiae isolate ADdelta overexpressing Candida krusei ERG11g after 48 hrs by liquid microdilution assay | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Abc1p is a multidrug efflux transporter that tips the balance in favor of innate azole resistance in Candida krusei. |
| AID489935 | Antifungal activity against Candida krusei TIMM 0269 after 24 hrs by microdilution method | 2010 | Bioorganic & medicinal chemistry letters, Jul-01, Volume: 20, Issue:13 | Novel pyridobenzimidazole derivatives exhibiting antifungal activity by the inhibition of beta-1,6-glucan synthesis. |
| AID544877 | Antimicrobial activity against Candida dubliniensis harboring MRR1 CD51-2A mutant gene by microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | Gain-of-function mutations in the transcription factor MRR1 are responsible for overexpression of the MDR1 efflux pump in fluconazole-resistant Candida dubliniensis strains. |
| AID1872501 | Antifungal activity against Candida krusei | 2022 | European journal of medicinal chemistry, Mar-05, Volume: 231 | Synthetic approaches and structural diversity of triazolylbutanols derived from voriconazole in the antifungal drug development. |
| AID424906 | Antimicrobial activity against azole-resistant Candida albicans isolate CA10 assessed as growth at 16 ug/ml cotreated with 0.008 ug/ml calcineurin signaling inhibitor tacrolimus after 48 hrs by microdilution checkerboard technique relative to control | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | In vitro interactions between tacrolimus and azoles against Candida albicans determined by different methods. |
| AID1201584 | Antifungal activity against Chrysosporium keratinophilum at 1 mg/ml incubated for 3 days | 2015 | European journal of medicinal chemistry, May-05, Volume: 95 | Synthesis and biological evaluation of new imidazo[2,1-b][1,3,4]thiadiazole-benzimidazole derivatives. |
| AID753238 | Antifungal activity against Candida utilis after 24 hrs by two-fold serial dilution method | 2013 | European journal of medicinal chemistry, Jun, Volume: 64 | Design, synthesis and antimicrobial evaluation of novel benzimidazole type of Fluconazole analogues and their synergistic effects with Chloromycin, Norfloxacin and Fluconazole. |
| AID1864899 | Antifungal activity against fluconazole- resistant Candida albicans CaR assessed as fungal growth inhibition measured after 72 hrs in presence of naproxen by double dilution method | |||
| AID395833 | Antimicrobial activity against Pseudomonas aeruginosa ATCC BAA427 after 24 hrs by standard microbroth dilution assay | 2009 | European journal of medicinal chemistry, Jan, Volume: 44, Issue:1 | Tetrahydronaphthyl azole oxime ethers: the conformationally rigid analogues of oxiconazole as antibacterials. |
| AID1416197 | Antifungal activity against Candida albicans by two-fold serial dilution method | 2017 | MedChemComm, Aug-01, Volume: 8, Issue:8 | Discovery of potential antifungal triazoles: design, synthesis, biological evaluation, and preliminary antifungal mechanism exploration. |
| AID515014 | Antifungal activity against Candida kefyr by micro-broth dilution method | 2010 | European journal of medicinal chemistry, Oct, Volume: 45, Issue:10 | Synthesis and antifungal evaluation of novel triazole derivatives as inhibitors of cytochrome P450 14alpha-demethylase. |
| AID1379936 | Antifungal activity against Candida albicans clinical isolates assessed as inhibition of microbial growth incubated for 24 hrs by broth microdilution method | 2017 | European journal of medicinal chemistry, Nov-10, Volume: 140 | Synthesis, biological evaluation and quantitative structure-active relationships of 1,3-thiazolidin-4-one derivatives. A promising chemical scaffold endowed with high antifungal potency and low cytotoxicity. |
| AID1890283 | Antifungal activity against Aspergillus nidulans clinical isolate 1 assessed as reduction in fungal growth by broth dilution method | 2022 | Bioorganic & medicinal chemistry letters, 05-01, Volume: 63 | Novel 2-aryl-4-aryloxyquinoline-based fungistatics for Mucor circinelloides. Biological evaluation of activity, QSAR and docking study. |
| AID405009 | Antifungal activity against Sporothrix schenckii P0019 isolate from cutaneous-lymphatic sporotrichosis patient after 72 hrs by modified NCCLS M38-A method | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | In vitro susceptibility of Sporothrix schenckii to six antifungal agents determined using three different methods. |
| AID1905281 | Antibiofilm activity against Candida albicans 904 assessed as inhibition of bacterial metabolism within the biofilm after 48 hrs by XTT reduction assay | 2022 | Journal of medicinal chemistry, 04-14, Volume: 65, Issue:7 | Species-Selective Targeting of Fungal Hsp90: Design, Synthesis, and Evaluation of Novel 4,5-Diarylisoxazole Derivatives for the Combination Treatment of Azole-Resistant Candidiasis. |
| AID717773 | Antimicrobial activity against Absidia corymbifera 272 after 48 hrs by broth microdilution test | 2012 | Bioorganic & medicinal chemistry, Dec-15, Volume: 20, Issue:24 | Contribution to investigation of antimicrobial activity of styrylquinolines. |
| AID392364 | Antifungal activity against Trichosporon beigelii 1188 after 24 hrs by broth microdilution method | 2009 | Bioorganic & medicinal chemistry letters, Jan-15, Volume: 19, Issue:2 | Salicylanilide esters of N-protected amino acids as novel antimicrobial agents. |
| AID518156 | Antimicrobial activity against Cryptococcus gattii serotype C isolate NIH257 assessed as concentration required for heteroresistance | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Heteroresistance of Cryptococcus gattii to fluconazole. |
| AID777333 | Antifungal activity against Candida albicans isolated from patient assessed as growth inhibition after 24 to 48 hrs by microbroth dilution method | 2013 | ACS medicinal chemistry letters, Oct-10, Volume: 4, Issue:10 | Identification of 1-[4-Benzyloxyphenyl)-but-3-enyl]-1H-azoles as New Class of Antitubercular and Antimicrobial Agents. |
| AID719449 | Antifungal activity against Aspergillus flavus MTCC 3306 at 500 ug/mL after 72 hrs by well plate method | 2012 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 22, Issue:24 | Synthesis, antioxidant and antimicrobial activity of novel vanillin derived piperidin-4-one oxime esters: preponderant role of the phenyl ester substituents on the piperidin-4-one oxime core. |
| AID1391392 | Antifungal activity against Candida albicans ATCC 90023 after 24 hrs by two fold serial dilution method | 2018 | Bioorganic & medicinal chemistry letters, 05-15, Volume: 28, Issue:9 | Novel purine benzimidazoles as antimicrobial agents by regulating ROS generation and targeting clinically resistant Staphylococcus aureus DNA groove. |
| AID1411880 | Inhibition of ergosterol biosynthesis in fluconazole susceptible Candida albicans ATCC 90028 at 8 ug/ml relative to control | 2017 | MedChemComm, Dec-01, Volume: 8, Issue:12 | Synergistic antifungal effect of cyclized chalcone derivatives and fluconazole against |
| AID1890282 | Antifungal activity against Epidermophyton floccosum clinical isolate 1 assessed as reduction in fungal growth by broth dilution method | 2022 | Bioorganic & medicinal chemistry letters, 05-01, Volume: 63 | Novel 2-aryl-4-aryloxyquinoline-based fungistatics for Mucor circinelloides. Biological evaluation of activity, QSAR and docking study. |
| AID1355711 | Antifungal activity against FLC resistant Candida albicans 0710922 after 48 hrs by checkerboard microdilution method | 2018 | Journal of medicinal chemistry, Jul-26, Volume: 61, Issue:14 | Discovery of Janus Kinase 2 (JAK2) and Histone Deacetylase (HDAC) Dual Inhibitors as a Novel Strategy for the Combinational Treatment of Leukemia and Invasive Fungal Infections. |
| AID1904363 | Antifungal activity against Aspergillus fumigatus CGMCC 3.7795 assessed as fungal growth inhibition by CLSI based serial microbroth dilution method | 2022 | European journal of medicinal chemistry, Apr-05, Volume: 233 | Design, synthesis, and evaluation of novel 3-thiophene derivatives as potent fungistatic and fungicidal reagents based on a conformational restriction strategy. |
| AID1918364 | Antifungal activity against Candida albicans infected in mouse assessed as increase in animal's body weight at 20 mg/kg, ip administered on days 2,4,6,8,10,12 and measured on day 14 | 2022 | Journal of medicinal chemistry, 11-10, Volume: 65, Issue:21 | Novel Aryl Alkamidazole Derivatives as Multifunctional Antifungal Inhibitors: Design, Synthesis, and Biological Evaluation. |
| AID521529 | Antifungal activity against Candida albicans ATCC MYA-2732 after 47 hrs by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | In vitro and in vivo antifungal activities of T-2307, a novel arylamidine. |
| AID1585636 | Antifungal activity against Saccharomyces cerevisiae SC XH1549 cultured in YNB media after 48 hrs by broth microdilution method | 2019 | European journal of medicinal chemistry, Jan-15, Volume: 162 | Chemical preparation, biological evaluation and 3D-QSAR of ethoxysulfuron derivatives as novel antifungal agents targeting acetohydroxyacid synthase. |
| AID424910 | Antimicrobial activity against azole-resistant Candida albicans isolate CA10 assessed as growth at 0.125 ug/ml co-treated with 0.004 ug/ml calcineurin signaling inhibitor tacrolimus after 48 hrs by microdilution checkboard technique relative to control | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | In vitro interactions between tacrolimus and azoles against Candida albicans determined by different methods. |
| AID609896 | Antifungal activity against Aspergillus fumigatus by micro-broth dilution method | 2011 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 21, Issue:15 | Synthesis, in vitro evaluation and molecular docking studies of new triazole derivatives as antifungal agents. |
| AID550088 | Antifungal activity against Candida albicans MTCC-183 after 48 hrs by broth microdilution assay | 2011 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 21, Issue:1 | Design and synthesis of 3-(azol-1-yl)phenylpropanes as microbicidal spermicides for prophylactic contraception. |
| AID1310920 | Inhibition of recombinant human CYP2C9 by P450-Glo luminescence assay | 2016 | Journal of medicinal chemistry, 05-26, Volume: 59, Issue:10 | 2-(3-Methoxyphenyl)quinazoline Derivatives: A New Class of Direct Constitutive Androstane Receptor (CAR) Agonists. |
| AID1542742 | Antifungal activity against Candida albicans ATCC 90028 measured after 36 hrs | 2019 | Bioorganic & medicinal chemistry, 05-15, Volume: 27, Issue:10 | 6-Bromoindolglyoxylamido derivatives as antimicrobial agents and antibiotic enhancers. |
| AID1758044 | Inhibition of CYP51 in Candida albicans ATCC SC5314 assessed as Eburicol level at 2 ug/ml after 16 hrs by GC-MS analysis (Rvb = 0%) | 2021 | European journal of medicinal chemistry, Apr-15, Volume: 216 | Lead optimization generates selenium-containing miconazole CYP51 inhibitors with improved pharmacological profile for the treatment of fungal infections. |
| AID574602 | Antifungal activity against Candida glabrata 20/I after 24 hrs by broth microdilution method | 2011 | Bioorganic & medicinal chemistry, Feb-15, Volume: 19, Issue:4 | Synthesis and antimycobacterial properties of N-substituted 6-amino-5-cyanopyrazine-2-carboxamides. |
| AID428913 | Antifungal activity against Cryptococcus neoformans ATCC 24067 after 72 hrs by NCCLS M27A method | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Voriconazole inhibits melanization in Cryptococcus neoformans. |
| AID285857 | Antimicrobial susceptibility of Pichia anomala from nosocomial fungemia patient assessed as percent susceptible isolates at 0.5 ug/ml by CLSI method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Antifungal drug susceptibility profile of Pichia anomala isolates from patients presenting with nosocomial fungemia. |
| AID1524625 | Antifungal activity against Candida albicans 7535 after 24 hrs by microtiter ELISA | 2019 | Bioorganic & medicinal chemistry letters, 05-01, Volume: 29, Issue:9 | Synthesis of novel dihydrotriazine derivatives bearing 1,3-diaryl pyrazole moieties as potential antibacterial agents. |
| AID1770945 | Antifungal activity against fluconazole-sensitive Candida albicans 904 assessed as fungal growth inhibition by CLSI protocol based method | 2021 | European journal of medicinal chemistry, Dec-05, Volume: 225 | Design, synthesis and evaluation of novel 5-phenylthiophene derivatives as potent fungicidal of Candida albicans and antifungal reagents of fluconazole-resistant fungi. |
| AID664485 | Plasma protein binding in human | 2012 | Journal of medicinal chemistry, Apr-12, Volume: 55, Issue:7 | Synthesis, biological evaluation, and structure-activity relationships of N-benzoyl-2-hydroxybenzamides as agents active against P. falciparum (K1 strain), Trypanosomes, and Leishmania. |
| AID392369 | Antifungal activity against Candida tropicalis ATCC 156 after 48 hrs by broth microdilution method | 2009 | Bioorganic & medicinal chemistry letters, Jan-15, Volume: 19, Issue:2 | Salicylanilide esters of N-protected amino acids as novel antimicrobial agents. |
| AID1180306 | Fungicidal activity against Cryptococcus neoformans NCIM-3378 after 48 to 72 hrs by two fold serial macrodilution technique | 2014 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 24, Issue:15 | One pot three components microwave assisted and conventional synthesis of new 3-(4-chloro-2-hydroxyphenyl)-2-(substituted) thiazolidin-4-one as antimicrobial agents. |
| AID1770948 | Antifungal activity against fluconazole-sensitive Candida albicans 103 assessed as fungal growth inhibition by CLSI protocol based method | 2021 | European journal of medicinal chemistry, Dec-05, Volume: 225 | Design, synthesis and evaluation of novel 5-phenylthiophene derivatives as potent fungicidal of Candida albicans and antifungal reagents of fluconazole-resistant fungi. |
| AID530971 | Antifungal activity against Aspergillus fumigatus ATCC 90906 at 163.3 uM after 48 hrs by CLSI method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Potent in vitro antifungal activities of naturally occurring acetylenic acids. |
| AID1369479 | Antifungal activity against Candida albicans cgmcc 2.2086 in presence of NH4Cl by broth dilution method | 2018 | Journal of medicinal chemistry, 05-10, Volume: 61, Issue:9 | Combating Drug-Resistant Fungi with Novel Imperfectly Amphipathic Palindromic Peptides. |
| AID582219 | Antifungal activity against Candida glabrata isolated from HSCT recipients with acute or chronic GVHD receiving posaconazole by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Impact of antifungal prophylaxis on colonization and azole susceptibility of Candida species. |
| AID589645 | Antifungal activity against Fusarium oxysporum | 2011 | European journal of medicinal chemistry, Apr, Volume: 46, Issue:4 | Synthesis of some novel 3-(1-(1-substitutedpiperidin-4-yl)-1H-1,2,3-triazol-4-yl)-5-substituted phenyl-1,2,4-oxadiazoles as antifungal agents. |
| AID1125794 | Antifungal activity against Candida albicans MTCC 183 assessed as diameter of growth inhibition zone at 10 ug/ml after 4 days by agar disc diffusion method | 2014 | European journal of medicinal chemistry, Apr-22, Volume: 77 | New polyfunctional imidazo[4,5-C]pyridine motifs: synthesis, crystal studies, docking studies and antimicrobial evaluation. |
| AID1198422 | Anticandidal activity against Candida tropicalis ATCC 750 incubated at 37 degC for 24 hrs in presence of 8-((1-Benzyl-1H-1,2,3-triazol-4-yl)methoxy)quinoline by broth micro dilution method | 2015 | European journal of medicinal chemistry, Mar-26, Volume: 93 | Synthesis, QSAR and anticandidal evaluation of 1,2,3-triazoles derived from naturally bioactive scaffolds. |
| AID1728461 | Antifungal activity against Aspergillus fumigatus KM8001 assessed as inhibition of microbial growth by NCCLS protocol based method | 2021 | European journal of medicinal chemistry, Jan-15, Volume: 210 | Novel naphthylamide derivatives as dual-target antifungal inhibitors: Design, synthesis and biological evaluation. |
| AID1079946 | Presence of at least one case with successful reintroduction. [column 'REINT' in source] | |||
| AID352612 | Antifungal activity against Trichophyton mentagrophytes after 96 hrs by micro broth dilution method | 2009 | European journal of medicinal chemistry, Mar, Volume: 44, Issue:3 | 2,3-Disubstituted-1,4-naphthoquinones, 12H-benzo[b]phenothiazine-6,11-diones and related compounds: synthesis and biological evaluation as potential antiproliferative and antifungal agents. |
| AID549051 | Antifungal activity against Candida albicans CA135 after 48 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | In vitro activities of retigeric acid B alone and in combination with azole antifungal agents against Candida albicans. |
| AID563115 | Antifungal activity against Candida glabrata ATCC 90030 after 48 hrs by broth microdilution method in presence of 2% glucose | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | T-2307 shows efficacy in a murine model of Candida glabrata infection despite in vitro trailing growth phenomena. |
| AID1320772 | Antifungal activity against Colletotrichum coccodes MC1 assessed as radial growth inhibition at 32 ug/ml after 5 to 7 days relative to control | 2016 | Bioorganic & medicinal chemistry, 11-15, Volume: 24, Issue:22 | Synthesis of novel tetrazole derivatives and evaluation of their antifungal activity. |
| AID1548540 | Antifungal activity against fluconazole-susceptible Candida albicans assessed as growth inhibition measured after 24 hrs by CLSI protocol based broth microdilution method | 2020 | ACS medicinal chemistry letters, Apr-09, Volume: 11, Issue:4 | Azole Based Acetohydrazide Derivatives of Cinnamaldehyde Target and Kill |
| AID1759438 | Antifungal activity against Cryptococcus neoformans PFCC 93-589 assessed as inhibition of melanin production at 0.5 times MIC incubated for 2 to 10 days | 2021 | Bioorganic & medicinal chemistry letters, 06-01, Volume: 41 | Inhibitory effects and mechanism of antifungal action of the natural cyclic depsipeptide, aureobasidin A against Cryptococcus neoformans. |
| AID489933 | Antifungal activity against Candida albicans ATCC 24433 after 24 hrs by microdilution method | 2010 | Bioorganic & medicinal chemistry letters, Jul-01, Volume: 20, Issue:13 | Novel pyridobenzimidazole derivatives exhibiting antifungal activity by the inhibition of beta-1,6-glucan synthesis. |
| AID525594 | Antibacterial activity against Fluconazole resistant Candida albicans DSY3706 containing tac1delta/delta ERG11-1/ERG11-1 genotype by EUCAST standards based broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Genetic dissection of azole resistance mechanisms in Candida albicans and their validation in a mouse model of disseminated infection. |
| AID341408 | Antimicrobial activity against 9 x 10'6 CFU Cryptococcus neoformans USC1597 isolate intracranially infected in Hartley guinea pig assessed as cerebrospinal fluid bacterial count per ml at 10 mg/kg, po BID administered 48 hrs postinfection for 13 days | 2007 | Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8 | New guinea pig model of Cryptococcal meningitis. |
| AID425163 | Antifungal activity against Candida glabrata isolate 4205 after 48 hrs by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | Posaconazole activity against Candida glabrata after exposure to caspofungin or amphotericin B. |
| AID745259 | Antifungal activity against Cryptococcus neoformans clinical isolate after 18 to 24 hrs by micro-dilution method | 2013 | European journal of medicinal chemistry, May, Volume: 63 | Design, synthesis and antimicrobial activity of novel benzothiazole analogs. |
| AID772334 | Antifungal activity against wild type Candida krusei ATCC 14243 after 24 hrs by visually and spectrophotometric analysis | 2013 | ACS medicinal chemistry letters, Sep-12, Volume: 4, Issue:9 | Novel Macrocyclic Amidinoureas: Potent Non-Azole Antifungals Active against Wild-Type and Resistant Candida Species. |
| AID1430053 | Anti-fungal activity against Sporothrix schenckii after 48 hrs by broth microdilution method | |||
| AID1820639 | Antifungal activity against Candida tropicalis GIM 2.183 assessed as inhibition of fungal growth by NCCLS protocol based method | 2022 | European journal of medicinal chemistry, Jan-15, Volume: 228 | Design, synthesis, and biological activity evaluation of 2-(benzo[b]thiophen-2-yl)-4-phenyl-4,5-dihydrooxazole derivatives as broad-spectrum antifungal agents. |
| AID1270916 | Antibiofilm activity against Candida albicans ATCC 24433 after 24 hrs by XTT-based colorimetric assay | 2015 | Journal of natural products, Nov-25, Volume: 78, Issue:11 | Synergistic Antifungal Meroterpenes and Dioxolanone Derivatives from the Endophytic Fungus Guignardia sp. |
| AID1584752 | Drug metabolism in human liver microsome S9 fraction assessed as CYP450-mediated metabolism by measuring compound remaining at 5 uM pretreated with NADPH and measured after 30 mins by UPLC-MS/MS analysis | 2018 | Journal of medicinal chemistry, 10-25, Volume: 61, Issue:20 | Discovery of Novel 7-Aryl 7-Deazapurine 3'-Deoxy-ribofuranosyl Nucleosides with Potent Activity against Trypanosoma cruzi. |
| AID1694059 | Antifungal activity against Candida albicans CS35 assessed as reduction in fungal growth incubated for 18 hrs by two-fold serial dilution method | 2021 | Bioorganic & medicinal chemistry, 02-01, Volume: 31 | Synthesis, anticancer and antimicrobial evaluation of new benzofuran based derivatives: PI3K inhibition, quorum sensing and molecular modeling study. |
| AID1157172 | Antifungal activity against Trichophyton mentagrophytes PMC 6515 after 72 hrs by CLSI broth microdilution method | 2014 | European journal of medicinal chemistry, Aug-18, Volume: 83 | Synthesis, biological evaluation and structure-activity correlation study of a series of imidazol-based compounds as Candida albicans inhibitors. |
| AID405109 | Antimicrobial activity against Rhizomucor sp. assessed as percent of susceptible isolates after 24 hrs | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | In vitro susceptibilities of 217 clinical isolates of zygomycetes to conventional and new antifungal agents. |
| AID285693 | Inhibition of Staphylococcus epidermidis Hay ATCC 55133 at 1 ug/ml by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Neonatal coinfection model of coagulase-negative Staphylococcus (Staphylococcus epidermidis) and Candida albicans: fluconazole prophylaxis enhances survival and growth. |
| AID1067046 | Antifungal activity against Candida parapsilosis by micro-broth dilution method | 2014 | European journal of medicinal chemistry, Mar-03, Volume: 74 | Synthesis, antifungal activities and molecular docking studies of novel 2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propyl dithiocarbamates. |
| AID1890300 | Antifungal activity against Mucor circinelloides M5 strain assessed as few mycelia with several spores at 50 ug/ml by microscopic analysis | 2022 | Bioorganic & medicinal chemistry letters, 05-01, Volume: 63 | Novel 2-aryl-4-aryloxyquinoline-based fungistatics for Mucor circinelloides. Biological evaluation of activity, QSAR and docking study. |
| AID1624186 | Antifungal activity against Cryptococcus neoformans NR-41292 after 24 hrs by microbroth dilution method | 2019 | Bioorganic & medicinal chemistry letters, 03-01, Volume: 29, Issue:5 | Benzimidazole tethered pyrrolo[3,4-b]quinoline with broad-spectrum activity against fungal pathogens. |
| AID1886028 | Synergistic antifungal activity against Cryptococcus neoformans H99 assessed as fractional inhibitory concentration index incubated for 72 hrs in presence of P163-0892 by broth microdilution method | |||
| AID1818270 | Antifungal activity against Candida glabrata ATCC 0001 assessed as reduction in fungal growth incubated for 72 hrs by CLSI protocol based broth microdilution method | |||
| AID561418 | Antifungal activity against Candida lusitaniae 6936 by microdilution method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Nonsense and missense mutations in FCY2 and FCY1 genes are responsible for flucytosine resistance and flucytosine-fluconazole cross-resistance in clinical isolates of Candida lusitaniae. |
| AID477744 | Antimicrobial activity against Sporothrix schenckii after 24 hrs | 2010 | European journal of medicinal chemistry, Apr, Volume: 45, Issue:4 | An eco-friendly synthesis and antimicrobial activities of dihydro-2H-benzo- and naphtho-1,3-oxazine derivatives. |
| AID1888260 | Antifungal activity against Candida glabrata ATCC 0001 assessed as fungal growth inhibition measured after 72 hrs by CLSI protocol based liquid medium dilution method | |||
| AID521971 | Antibacterial activity against azole-susceptible Candida albicans DSY294 containing CIp10 to restore URA3 function infected in BALB/c mouse assessed as reduction in kidney microbial burden administered intraperitoneally 1 hr post bacterial challenge measu | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Genetic dissection of azole resistance mechanisms in Candida albicans and their validation in a mouse model of disseminated infection. |
| AID279100 | Ratio of weight normalized daily dose in candidemia patient to MIC against Candida lusitaniae | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Association of fluconazole area under the concentration-time curve/MIC and dose/MIC ratios with mortality in nonneutropenic patients with candidemia. |
| AID309263 | Antifungal activity against Cryptococcus neoformans ATCC 32045 after 48 to 72 hrs | 2007 | Bioorganic & medicinal chemistry, Nov-01, Volume: 15, Issue:21 | Synthesis of chlorogenic acid derivatives with promising antifungal activity. |
| AID371236 | Antimicrobial activity against Aspergillus fumigatus SANK 10569 by broth microdilution method | 2008 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 18, Issue:24 | Carbon analogs of antifungal dioxane-triazole derivatives: synthesis and in vitro activities. |
| AID750176 | Antifungal activity against Candida albicans after 24 hrs by NCCLS method | 2013 | European journal of medicinal chemistry, Jun, Volume: 64 | Discovery of highly potent triazole antifungal derivatives by heterocycle-benzene bioisosteric replacement. |
| AID1818283 | Induction of apoptosis against Candida albicans ATCC SC5314 assessed as late apoptotic cells measured after 48 hrs by by Annexin V-FITC/propidium iodide staining based flow cytometry (Rvb = 0.71 %) | |||
| AID395835 | Antimicrobial activity against Candida albicans after 48 hrs by standard microbroth dilution assay | 2009 | European journal of medicinal chemistry, Jan, Volume: 44, Issue:1 | Tetrahydronaphthyl azole oxime ethers: the conformationally rigid analogues of oxiconazole as antibacterials. |
| AID420660 | Antifungal activity against Candida albicans ATCC 76615 after 24 hrs by micro-broth dilution method | 2009 | European journal of medicinal chemistry, May, Volume: 44, Issue:5 | Design, synthesis, and biological evaluation of novel triazole derivatives as inhibitors of cytochrome P450 14alpha-demethylase. |
| AID532572 | Antifungal activity against wild-type Candida glabrata isolate 21231 by disk diffusion method | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | A nonsense mutation in the ERG6 gene leads to reduced susceptibility to polyenes in a clinical isolate of Candida glabrata. |
| AID1274473 | Antifungal activity against Aspergillus flavus ATCC 16870 after 24 hrs by two-fold serial dilution method | 2016 | European journal of medicinal chemistry, Jan-27, Volume: 108 | Synthesis and biological evaluation of novel phosphoramidate derivatives of coumarin as chitin synthase inhibitors and antifungal agents. |
| AID581885 | Antifungal activity against Candida glabrata isolated from HSCT recipient 270 with acute or chronic GVHD mouth receiving antifungal drug after 108 days prophylaxis by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Impact of antifungal prophylaxis on colonization and azole susceptibility of Candida species. |
| AID757548 | Anticandida activity against Candida krusei clinical isolate assessed as growth inhibition after 24 hrs by broth microdilution method | 2013 | European journal of medicinal chemistry, Jul, Volume: 65 | Synthesis and cytotoxicity of novel (thiazol-2-yl)hydrazine derivatives as promising anti-Candida agents. |
| AID1304740 | Antifungal activity against Trichophyton rubrum measured after 7 days by serial dilution method | 2016 | Journal of medicinal chemistry, Apr-14, Volume: 59, Issue:7 | Discovery of Potent Benzofuran-Derived Diapophytoene Desaturase (CrtN) Inhibitors with Enhanced Oral Bioavailability for the Treatment of Methicillin-Resistant Staphylococcus aureus (MRSA) Infections. |
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| AID1334847 | Anti-fungal activity against Candida albicans SC5314 by broth microdilution method | 2017 | Bioorganic & medicinal chemistry, 01-15, Volume: 25, Issue:2 | Discovery of biphenyl imidazole derivatives as potent antifungal agents: Design, synthesis, and structure-activity relationship studies. |
| AID55034 | In vitro antifungal activity against Cryptococcus neoformans | 2003 | Journal of medicinal chemistry, Feb-13, Volume: 46, Issue:4 | Structure-based de novo design, synthesis, and biological evaluation of non-azole inhibitors specific for lanosterol 14alpha-demethylase of fungi. |
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| AID1494152 | Antifungal activity against Candida parapsilosis after 5 to 7 days | 2018 | European journal of medicinal chemistry, Jan-01, Volume: 143 | Molecular docking, design, synthesis and antifungal activity study of novel triazole derivatives. |
| AID1864928 | Toxicity in mouse infected with Candida albicans assessed as BUN level in plasma at 10 ug per 20 g, ip administered on day 2, 4, 6, 8, 10 and 12 and measured on day 14 in presence of naproxen (Rvb = 8.2 +/- 0.5 mmol/L) | |||
| AID420079 | Antifungal activity against Cryptococcus neoformans CAP67 after 48 hrs by broth microdilution assay | 2009 | Bioorganic & medicinal chemistry, Jun-01, Volume: 17, Issue:11 | Bulky 1,4-benzoxazine derivatives with antifungal activity. |
| AID554706 | Antimicrobial activity against Candida krusei IFO0011 after 48 hrs by liquid microdilution assay | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Abc1p is a multidrug efflux transporter that tips the balance in favor of innate azole resistance in Candida krusei. |
| AID1079937 | Severe hepatitis, defined as possibly life-threatening liver failure or through clinical observations. Value is number of references indexed. [column 'MASS' in source] | |||
| AID1329755 | Antifungal activity against Rhodotorula mucilaginosa ATCC 66034 after 48 hrs by broth microdilution method | |||
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| AID42877 | Inhibition of Candida krusei E28 growth for 48 hours in vitro. | 2001 | Journal of medicinal chemistry, Aug-16, Volume: 44, Issue:17 | 3-Phenyl-5-acyloxymethyl-2H,5H-furan-2-ones: synthesis and biological activity of a novel group of potential antifungal drugs. |
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| AID1369468 | Fungicidal activity against Candida parapsilosis cgmcc 2.3989 after 96 hrs | 2018 | Journal of medicinal chemistry, 05-10, Volume: 61, Issue:9 | Combating Drug-Resistant Fungi with Novel Imperfectly Amphipathic Palindromic Peptides. |
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| AID1898214 | Antifungal activity against Cryptococcus neoformans H99 infected in ICR mouse assessed as delay in mortality at 2 mg/kg, po qd infected with fungus for 2 hrs prior to compound addition for 7 days and measured for 20 days | |||
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| AID766644 | Antifungal activity against Candida albicans MTCC 7315 after 24 hrs by well diffusion method | 2013 | European journal of medicinal chemistry, Sep, Volume: 67 | Total synthesis and biological evaluation of clavaminol-G and its analogs. |
| AID1054557 | Antifungal activity against Candida albicans MTCC 183 after 48 hrs by broth microdilution technique | 2013 | European journal of medicinal chemistry, , Volume: 70 | Azole-carbodithioate hybrids as vaginal anti-Candida contraceptive agents: design, synthesis and docking studies. |
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| AID1593114 | Antimicrobial activity against Candida albicans ATCC 90028 incubated for 48 hrs by agar well diffusion assay | 2019 | European journal of medicinal chemistry, Apr-15, Volume: 168 | Design, synthesis and biological evaluation of novel α-acyloxy carboxamides via Passerini reaction as caspase 3/7 activators. |
| AID1885953 | Antifungal activity against Aspergillus fumigatus 7544 assessed as fungal growth inhibition incubated for 48 hrs by broth microdilution method | |||
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| AID1391317 | Antibacterial activity against Pseudomonas aeruginosa 2742 after 24 hrs by two-fold serial dilution method | 2018 | Bioorganic & medicinal chemistry letters, 05-15, Volume: 28, Issue:9 | Synthesis and evaluation of the antibacterial activities of aryl substituted dihydrotriazine derivatives. |
| AID1818275 | Antifungal activity against Candida albicans strain CaR assessed as reduction in fungal growth incubated for 72 hrs by CLSI protocol based broth microdilution method | |||
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| AID432214 | Antifungal activity against Candida albicans after 16 to 18 hrs by serial dilution method | 2009 | European journal of medicinal chemistry, Sep, Volume: 44, Issue:9 | Regioselective reaction: synthesis, characterization and pharmacological studies of some new Mannich bases derived from 1,2,4-triazoles. |
| AID1888258 | Antifungal activity against Candida albicans ATCC 10231 assessed as fungal growth inhibition measured after 72 hrs by CLSI protocol based liquid medium dilution method | |||
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| AID609894 | Antifungal activity against Cryptococcus neoformans BLS108 by micro-broth dilution method | 2011 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 21, Issue:15 | Synthesis, in vitro evaluation and molecular docking studies of new triazole derivatives as antifungal agents. |
| AID1498764 | Antifungal activity against Candida utilis after 24 hrs by two fold serial dilution based spectrophotometric analysis | 2018 | Bioorganic & medicinal chemistry letters, 08-01, Volume: 28, Issue:14 | Azoalkyl ether imidazo[2,1-b]benzothiazoles as potentially antimicrobial agents with novel structural skeleton. |
| AID518453 | Antimicrobial activity against Cryptococcus gattii serotype C isolate NIH34 assessed as heteroresistant isolates at 4 ug/ml | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Heteroresistance of Cryptococcus gattii to fluconazole. |
| AID1529795 | Antifungal activity against Cryptococcus neoformans H99 ATCC 208821 after 18 to 20 hrs by broth microdilution assay | 2018 | European journal of medicinal chemistry, Dec-05, Volume: 160 | Norbornane-based cationic antimicrobial peptidomimetics targeting the bacterial membrane. |
| AID1783070 | Antifungal activity against fluconazole-sensitive Candida albicans 9770 assessed as inhibition of fungal growth | 2021 | European journal of medicinal chemistry, Oct-05, Volume: 221 | Lanosterol 14α-demethylase (CYP51)/histone deacetylase (HDAC) dual inhibitors for treatment of Candida tropicalis and Cryptococcus neoformans infections. |
| AID1348792 | Antifungal activity against Sporothrix schenckii after 48 hrs by broth microdilution method | 2018 | European journal of medicinal chemistry, Jan-01, Volume: 143 | Substituted carbamothioic amine-1-carbothioic thioanhydrides as novel trichomonicidal fungicides: Design, synthesis, and biology. |
| AID287833 | Antifungal activity against Trichophyton mentagrophytes 445 after 72 hrs | 2007 | Bioorganic & medicinal chemistry, Apr-15, Volume: 15, Issue:8 | Hybrid molecules of estrone: new compounds with potential antibacterial, antifungal, and antiproliferative activities. |
| AID609977 | Antifungal activity against Rhizopus sp. at 1000 ug after 24 hrs by paper disc technique relative to control | 2011 | Bioorganic & medicinal chemistry letters, Aug-15, Volume: 21, Issue:16 | Efficient synthesis of antifungal active 9-substituted-3-aryl-5H,13aH-quinolino[3,2-f][1,2,4]triazolo[4,3-b][1,2,4]triazepines in ionic liquids. |
| AID665129 | Antifungal activity against 10 strains of Candida albicans after 24 hrs by EUCAST broth microdilution method | 2012 | European journal of medicinal chemistry, Jul, Volume: 53 | Synthesis, anti-Candida activity, and cytotoxicity of new (4-(4-iodophenyl)thiazol-2-yl)hydrazine derivatives. |
| AID1232310 | Volume of distribution at steady state in human | 2015 | Journal of medicinal chemistry, Aug-13, Volume: 58, Issue:15 | Volume of Distribution in Drug Design. |
| AID1056013 | Antifungal activity against Aspergillus niger ATCC 9029 after 24 hrs by broth microdilution method | 2013 | European journal of medicinal chemistry, , Volume: 70 | Synthesis, biological evaluation and docking studies of 4-aryloxymethyl coumarins derived from substructures and degradation products of vancomycin. |
| AID1154822 | Fungicidal activity against fluconazole-sensitive Candida albicans SC5314 at 32 ug/ml after 12 to 48 hrs | 2014 | ACS medicinal chemistry letters, May-08, Volume: 5, Issue:5 | Novel carboline derivatives as potent antifungal lead compounds: design, synthesis, and biological evaluation. |
| AID1205755 | Antifungal activity against Cryptococcus gattii 29/10893 after 72 hrs by microdilution method | 2015 | ACS medicinal chemistry letters, Mar-12, Volume: 6, Issue:3 | Synthesis of a New Peptide-Coumarin Conjugate: A Potential Agent against Cryptococcosis. |
| AID1157156 | Antifungal activity against Candida krusei PMC 0613 after 48 hrs by CLSI broth microdilution method | 2014 | European journal of medicinal chemistry, Aug-18, Volume: 83 | Synthesis, biological evaluation and structure-activity correlation study of a series of imidazol-based compounds as Candida albicans inhibitors. |
| AID1348789 | Antifungal activity against Candida albicans ATCC 10231 after 48 hrs by broth microdilution method | 2018 | European journal of medicinal chemistry, Jan-01, Volume: 143 | Substituted carbamothioic amine-1-carbothioic thioanhydrides as novel trichomonicidal fungicides: Design, synthesis, and biology. |
| AID340957 | Antifungal activity against Candida lambica isolates from grapes by NCCLS M27-A2 method | 2007 | Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8 | Cross-resistance to medical and agricultural azole drugs in yeasts from the oropharynx of human immunodeficiency virus patients and from environmental Bavarian vine grapes. |
| AID405093 | Antimicrobial activity against Rhizopus arrhizus after 24 hrs | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | In vitro susceptibilities of 217 clinical isolates of zygomycetes to conventional and new antifungal agents. |
| AID751635 | Antifungal activity against Aspergillus flavus at 500 ppm | 2013 | European journal of medicinal chemistry, Feb, Volume: 60 | Synthesis and antifungal activity of some s-mercaptotriazolobenzothiazolyl amino acid derivatives. |
| AID1557091 | Cytotoxicity against human HEK293T cells assessed as reduction in cell viability at 5 to 50 uM incubated for 24 hrs by XTT assay | 2019 | European journal of medicinal chemistry, Oct-01, Volume: 179 | Antifungal activity, mode of action variability, and subcellular distribution of coumarin-based antifungal azoles. |
| AID619181 | Antifungal activity against Candida albicans AN 1994 by broth dilution method | 2011 | Journal of medicinal chemistry, Oct-13, Volume: 54, Issue:19 | High-throughput-screening-based identification and structure-activity relationship characterization defined (S)-2-(1-aminoisobutyl)-1-(3-chlorobenzyl)benzimidazole as a highly antimycotic agent nontoxic to cell lines. |
| AID1179569 | Antibacterial activity against methicillin-resistant Staphylococcus aureus at 100 ug/well after 24 hrs by well diffusion assay | 2014 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 24, Issue:15 | Synthesis and SAR study of novel anticancer and antimicrobial naphthoquinone amide derivatives. |
| AID37848 | Inhibition of Aspergillus fumigatus 231 growth for 48 hours in vitro. | 2001 | Journal of medicinal chemistry, Aug-16, Volume: 44, Issue:17 | 3-Phenyl-5-acyloxymethyl-2H,5H-furan-2-ones: synthesis and biological activity of a novel group of potential antifungal drugs. |
| AID434899 | Antifungal activity against Candida tropicalis ATCC 750 in RPMI 1640 medium by broth dilution susceptibility test | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | In vitro study of Candida tropicalis isolates exhibiting paradoxical growth in the presence of high concentrations of caspofungin. |
| AID555014 | Antifungal activity against Candida rugosa assessed as percent susceptible isolates at 25 ug/disc by CLSI M44-A disk diffusion method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | In vitro activities of fluconazole and voriconazole against clinical isolates of Candida spp. determined by disk diffusion testing in Turin, Italy. |
| AID424897 | Antimicrobial activity against azole-resistant Candida albicans isolate CA10 assessed as growth at 64 ug/ml co-treated with 0.016 ug/ml calcineurin signaling inhibitor tacrolimus after 48 hrs by microdilution checkboard technique relative to control | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | In vitro interactions between tacrolimus and azoles against Candida albicans determined by different methods. |
| AID425130 | Antimicrobial activity against azole-resistant Candida albicans isolate CA10 assessed as growth at 32 ug/ml cotreated with 0.002 ug/ml calcineurin signaling inhibitor Tacrolimus after 48 hrs by microdilution checkboard technique relative to control | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | In vitro interactions between tacrolimus and azoles against Candida albicans determined by different methods. |
| AID1427211 | Antifungal activity against Trichophyton mentagrophytes 445 after 120 hrs by microdilution broth assay | 2017 | Bioorganic & medicinal chemistry, 03-15, Volume: 25, Issue:6 | Antimicrobial activity of rhodanine-3-acetic acid derivatives. |
| AID1885983 | Antifungal activity against Candida auris CBS 12372 assessed as fungal growth inhibition incubated for 48 hrs in presence of P163-0892 by broth microdilution method | |||
| AID1918352 | Induction of apoptosis in Candida albicans assessed as late apoptotic cells measured after 24 hrs by Annexin V-FITC/PI staining based flow cytometry (Rvb = 0.44%) | 2022 | Journal of medicinal chemistry, 11-10, Volume: 65, Issue:21 | Novel Aryl Alkamidazole Derivatives as Multifunctional Antifungal Inhibitors: Design, Synthesis, and Biological Evaluation. |
| AID518889 | Antimicrobial activity against Cryptococcus gattii serotype C isolate H0058-1-78 assessed as heteroresistant isolates at 32 ug/ml | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Heteroresistance of Cryptococcus gattii to fluconazole. |
| AID1689211 | Antifungal activity against fluconazole-resistant Candida albicans NR29448 assessed as reduction in fungal growth incubated for 24 hrs by CLSI based broth microdilution method | 2020 | European journal of medicinal chemistry, Mar-01, Volume: 189 | Oxadiazolylthiazoles as novel and selective antifungal agents. |
| AID1193897 | Antifungal activity against Aspergillus niger MTCC 282 assessed as zone of inhibition at 5 mg/ml after 24 hrs by agar well diffusion method | 2015 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 25, Issue:7 | Rapid 'one-pot' synthesis of a novel benzimidazole-5-carboxylate and its hydrazone derivatives as potential anti-inflammatory and antimicrobial agents. |
| AID1246771 | Selectivity index, ratio of IC50 for C57BL/6 mouse peritoneal macrophages to MIC for Cryptococcus gattii ATCC 24065 | 2015 | European journal of medicinal chemistry, Sep-18, Volume: 102 | Thiazole compounds with activity against Cryptococcus gattii and Cryptococcus neoformans in vitro. |
| AID1758045 | Inhibition of CYP51 in Candida albicans ATCC SC5314 assessed as Eburicol level at 8 ug/ml after 16 hrs by GC-MS analysis (Rvb = 0%) | 2021 | European journal of medicinal chemistry, Apr-15, Volume: 216 | Lead optimization generates selenium-containing miconazole CYP51 inhibitors with improved pharmacological profile for the treatment of fungal infections. |
| AID405197 | Antimicrobial activity against Blastoschizomyces capitatus IHEM 16105 isolate infected OF1 mouse blastoschizomycosis model assessed as liver microbial count per gram of tissue at 80 mg/kg/day, po for 6 days administered 1 hr before microbial challenge | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | Combined therapies in a murine model of blastoschizomycosis. |
| AID771485 | Antimicrobial activity against Candida albicans MTCC 183 at 50 ug/mL after 12 hrs by well diffusion method | 2013 | European journal of medicinal chemistry, Oct, Volume: 68 | Design and regioselective synthesis of trifluoromethylquinolone derivatives as potent antimicrobial agents. |
| AID1861419 | Antifungal activity against fluconazole-sensitive Candida albicans ATCC10231 assessed as inhibition of fungal growth by microdilution method | 2022 | Bioorganic & medicinal chemistry letters, 09-01, Volume: 71 | Discovery of novel indole and indoline derivatives against Candida albicans as potent antifungal agents. |
| AID1905254 | Synergistic antifungal activity against fluconazole-resistant Candida albicans 632 assessed as inhibition of fungal growth in presence of fluconazole by checker board microdilution assay | 2022 | Journal of medicinal chemistry, 04-14, Volume: 65, Issue:7 | Species-Selective Targeting of Fungal Hsp90: Design, Synthesis, and Evaluation of Novel 4,5-Diarylisoxazole Derivatives for the Combination Treatment of Azole-Resistant Candidiasis. |
| AID1624173 | Antifungal activity against Candida albicans NR5-29453 after 24 hrs by microbroth dilution method | 2019 | Bioorganic & medicinal chemistry letters, 03-01, Volume: 29, Issue:5 | Benzimidazole tethered pyrrolo[3,4-b]quinoline with broad-spectrum activity against fungal pathogens. |
| AID1079933 | Acute liver toxicity defined via clinical observations and clear clinical-chemistry results: serum ALT or AST activity > 6 N or serum alkaline phosphatases activity > 1.7 N. This category includes cytolytic, choleostatic and mixed liver toxicity. Value is | |||
| AID1898150 | Antifungal activity against Cryptococcus neoformans H99 incubated for 72 hrs by microbroth dilution method | |||
| AID1770961 | Cytotoxicity against human THLE-2 cells assessed as reduction in cell viability measured after 96 hrs by MTT assay | 2021 | European journal of medicinal chemistry, Dec-05, Volume: 225 | Design, synthesis and evaluation of novel 5-phenylthiophene derivatives as potent fungicidal of Candida albicans and antifungal reagents of fluconazole-resistant fungi. |
| AID262554 | Antifungal activity against Microsporum gypseum | 2006 | Journal of medicinal chemistry, Apr-20, Volume: 49, Issue:8 | Structure-based optimization of azole antifungal agents by CoMFA, CoMSIA, and molecular docking. |
| AID1320750 | Antifungal activity against Candida albicans ATCC 90028 assessed as growth inhibition after 48 hrs by broth microdilution method | 2016 | Bioorganic & medicinal chemistry, 11-15, Volume: 24, Issue:22 | Synthesis of novel tetrazole derivatives and evaluation of their antifungal activity. |
| AID1551839 | Antifungal activity against Aspergillus niger assessed as zone of inhibition at 100 ug/ml | 2019 | European journal of medicinal chemistry, Jul-15, Volume: 174 | 1,2,4-Triazole-quinoline/quinolone hybrids as potential anti-bacterial agents. |
| AID1357634 | Antifungal activity against Candida tropicalis ATCC 750 after 48 hrs by microbroth dilution assay | 2018 | European journal of medicinal chemistry, May-10, Volume: 151 | Synthesis, molecular modeling studies and evaluation of antifungal activity of a novel series of thiazole derivatives. |
| AID1877288 | Antifungal activity against FLC-resistant Candida albicans 901 assessed as fungal growth inhibition by NCCLS protocol based method | 2022 | European journal of medicinal chemistry, Jan-05, Volume: 227 | Broadening antifungal spectrum and improving metabolic stablity based on a scaffold strategy: Design, synthesis, and evaluation of novel 4-phenyl-4,5-dihydrooxazole derivatives as potent fungistatic and fungicidal reagents. |
| AID1419536 | Hemolytic activity in mouse erythrocytes assessed as hemolysis level at 31.3 ug/ml incubated for 1 hr at 37 degC | 2017 | European journal of medicinal chemistry, Jun-16, Volume: 133 | Novel alkylated azoles as potent antifungals. |
| AID598306 | Antimicrobial activity against Candida parapsilosis ATCC 22019 after 48 hrs by microdilution broth method | 2011 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 21, Issue:11 | Synthesis and in vitro antimicrobial activities of new (cyano-NNO-azoxy)pyrazole derivatives. |
| AID457981 | Antifungal activity against Candida parapsilosis ATCC 22019 after 24 hrs by microdilution method | 2010 | Bioorganic & medicinal chemistry, Mar-01, Volume: 18, Issue:5 | Antifungal 3,5-disubstituted furanones: From 5-acyloxymethyl to 5-alkylidene derivatives. |
| AID407007 | Antimicrobial activity against Candida albicans FH1 intact biofilms after 48 hrs by XTT assay | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | Role for cell density in antifungal drug resistance in Candida albicans biofilms. |
| AID1491269 | Inhibition of CYP51 in Candida albicans ATCC SC5314 assessed as eburicol content at 8 ug/ml by GS-MS analysis relative to total sterols (Rvb = 0.4%) | 2017 | European journal of medicinal chemistry, Sep-08, Volume: 137 | Design, synthesis and evaluation of aromatic heterocyclic derivatives as potent antifungal agents. |
| AID1572491 | Fungistatic activity against Cryptococcus neoformans var. grubii H99 at 16 ug/mL up to 48 hrs by time-growth curve assay | 2019 | Bioorganic & medicinal chemistry, 03-01, Volume: 27, Issue:5 | Discovery of novel simplified isoxazole derivatives of sampangine as potent anti-cryptococcal agents. |
| AID1759443 | Hemolytic activity in human RBC at 4 ug/ml incubated for 30 mins | 2021 | Bioorganic & medicinal chemistry letters, 06-01, Volume: 41 | Inhibitory effects and mechanism of antifungal action of the natural cyclic depsipeptide, aureobasidin A against Cryptococcus neoformans. |
| AID644836 | Antifungal activity against Candida parapsilosis DSM 11224 after 48 hrs by M27-A3 CLSI method | 2012 | European journal of medicinal chemistry, Mar, Volume: 49 | Synthesis and antifungal activity of a new series of 2-(1H-imidazol-1-yl)-1-phenylethanol derivatives. |
| AID1809901 | Fungicidal activity against Cryptococcus neoformans H99 at 8 times of MIC after 24 hrs by time-kill kinetics assay | 2021 | Journal of medicinal chemistry, 11-11, Volume: 64, Issue:21 | Optimization and Evaluation of Novel Antifungal Agents for the Treatment of Fungal Infection. |
| AID518135 | Antimicrobial activity against Cryptococcus gattii serotype B isolate RB-17 assessed as concentration required for heteroresistance | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Heteroresistance of Cryptococcus gattii to fluconazole. |
| AID609972 | Antifungal activity against Aspergillus flavus at 1000 ug after 24 hrs by paper disc technique | 2011 | Bioorganic & medicinal chemistry letters, Aug-15, Volume: 21, Issue:16 | Efficient synthesis of antifungal active 9-substituted-3-aryl-5H,13aH-quinolino[3,2-f][1,2,4]triazolo[4,3-b][1,2,4]triazepines in ionic liquids. |
| AID424894 | Antimicrobial activity against azole-resistant Candida albicans isolate CA10 assessed as growth at 8 ug/ml cotreated with 0.016 ug/ml calcineurin signaling inhibitor Tacrolimus after 48 hrs by microdilution checkboard technique relative to control | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | In vitro interactions between tacrolimus and azoles against Candida albicans determined by different methods. |
| AID518694 | Antimicrobial activity against Cryptococcus gattii serotype B isolate RB22 assessed as heteroresistant isolates at 16 ug/ml | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Heteroresistance of Cryptococcus gattii to fluconazole. |
| AID555004 | Antifungal activity against Candida kefyr assessed as percent susceptible isolates at 25 ug/disc by CLSI M44-A disk diffusion method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | In vitro activities of fluconazole and voriconazole against clinical isolates of Candida spp. determined by disk diffusion testing in Turin, Italy. |
| AID1671799 | Antifungal activity against Candida albicans ATCC 90023 assessed as inhibition of fungal growth after 24 hrs by CLSI protocol based two fold serial dilution method | 2019 | European journal of medicinal chemistry, Apr-01, Volume: 167 | Design and synthesis of aminothiazolyl norfloxacin analogues as potential antimicrobial agents and their biological evaluation. |
| AID776430 | Antifungal activity against Candida albicans ATCC 26555 at 50 ug/ml after 48 hrs by disc-diffusion method | 2013 | European journal of medicinal chemistry, Nov, Volume: 69 | Synthesis, antimicrobial, antioxidant activities of novel 6-aryl-5-cyano thiouracil derivatives. |
| AID1391311 | Antibacterial activity against Staphylococcus aureus 4220 after 24 hrs by two-fold serial dilution method | 2018 | Bioorganic & medicinal chemistry letters, 05-15, Volume: 28, Issue:9 | Synthesis and evaluation of the antibacterial activities of aryl substituted dihydrotriazine derivatives. |
| AID1330193 | Antifungal activity against Candida albicans 7535 measured after 24 hrs by two-fold serial dilution method | 2016 | Bioorganic & medicinal chemistry letters, 12-15, Volume: 26, Issue:24 | Synthesis and biological evaluation of chalcone derivatives containing aminoguanidine or acylhydrazone moieties. |
| AID1550464 | Antifungal activity against Candida krusei ATCC 6258 assessed as diameter of zone inhibition at 0.025 mg incubated for 24 hrs by disc diffusion method | 2019 | European journal of medicinal chemistry, Jun-01, Volume: 171 | Antimicrobial and KPC/AmpC inhibitory activity of functionalized benzosiloxaboroles. |
| AID307394 | Antifungal activity against Candida glabrata ATCC 34138 by broth microdilution assay | 2007 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 17, Issue:12 | Discovery of novel indazole-linked triazoles as antifungal agents. |
| AID1348089 | Antimicrobial activity against Bacillus subtilis subsp. subtilis ATCC 6051 assessed as zone of inhibition at 50 ug per disc after 24 hrs by disc diffusion assay | 2018 | European journal of medicinal chemistry, Jan-01, Volume: 143 | Synthesis of new 1-benzyl tetrahydropyridinylidene ammonium salts and their antimicrobial and anticellular activities. |
| AID520867 | Antifungal activity against Cryptococcus neoformans YC-11 infected in BALB/c mouse assessed as reduction in fungal burden in brain at 40 mg/kg, iv qd for 5 days measured after 7 days of infection | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | Efficacy of SPK-843, a novel polyene antifungal, in a murine model of systemic cryptococcosis. |
| AID604065 | Antifungal activity against Candida albicans MTCC 3017 after 18 hrs by microtiter broth dilution method | 2011 | European journal of medicinal chemistry, Jul, Volume: 46, Issue:7 | Total synthesis of racemic and (R) and (S)-4-methoxyalkanoic acids and their antifungal activity. |
| AID518169 | Antimicrobial activity against Cryptococcus gattii serotype C isolate H0058-1-1875 assessed as concentration required for heteroresistance | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Heteroresistance of Cryptococcus gattii to fluconazole. |
| AID420068 | Antifungal activity against Candida albicans CA-6 after 48 hrs by broth microdilution assay | 2009 | Bioorganic & medicinal chemistry, Jun-01, Volume: 17, Issue:11 | Bulky 1,4-benzoxazine derivatives with antifungal activity. |
| AID1543304 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus ATCC 43300 assessed as inhibition of microbial growth by CLSI based method | 2019 | Journal of natural products, 07-26, Volume: 82, Issue:7 | Anthraquinone-Based Specialized Metabolites from Rhizomes of |
| AID1818287 | Inhibition of SE/CYP51 in Candida albicans ATCC SC5314 assessed as ergosterol level incubated for 48 hrs by LC/MS analysis (Rvb = 91.7 %) | |||
| AID1157169 | Antifungal activity against Cryptococcus neoformans DSM 11959 after 72 hrs by CLSI broth microdilution method | 2014 | European journal of medicinal chemistry, Aug-18, Volume: 83 | Synthesis, biological evaluation and structure-activity correlation study of a series of imidazol-based compounds as Candida albicans inhibitors. |
| AID1279024 | Antifungal activity against Candida tropicalis 156 after 48 hrs by microbroth dilution method | 2016 | Bioorganic & medicinal chemistry, Mar-15, Volume: 24, Issue:6 | Salicylanilide N-monosubstituted carbamates: Synthesis and in vitro antimicrobial activity. |
| AID518428 | Antimicrobial activity against Cryptococcus gattii serotype B isolate NIH200 assessed as heteroresistant isolates at 4 ug/ml | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Heteroresistance of Cryptococcus gattii to fluconazole. |
| AID1059354 | Antifungal activity against Candida tropicalis clinical isolate after 20 hrs by agar dilution method | 2013 | European journal of medicinal chemistry, , Volume: 70 | Designing and synthesis of novel antimicrobial heterocyclic analogs of fatty acids. |
| AID1864943 | Inhibition of CYP51 in Candida albicans ATCC SC5314 assessed as ergosterol level at 4 ug/ml incuabted for 48 hrs by GC-MS analysis (Rvb = 96.48%) | |||
| AID1491247 | Antifungal activity against fluconazole-resistant Candida albicans strain 103 by broth microdilution method | 2017 | European journal of medicinal chemistry, Sep-08, Volume: 137 | Design, synthesis and evaluation of aromatic heterocyclic derivatives as potent antifungal agents. |
| AID1551804 | Antifungal activity against Candida albicans ATCC 50193 after 24 hrs by microdilution method | 2019 | European journal of medicinal chemistry, Jul-01, Volume: 173 | Antibacterial activity study of 1,2,4-triazole derivatives. |
| AID499663 | Antimicrobial activity against Candida tropicalis TIMM 0313 by microdilution assay | 2010 | Bioorganic & medicinal chemistry, Aug-15, Volume: 18, Issue:16 | Novel antifungal agents: triazolopyridines as inhibitors of beta-1,6-glucan synthesis. |
| AID1818278 | Antifungal activity against Candida albicans strain 904 assessed as reduction in fungal growth incubated for 72 hrs by CLSI protocol based broth microdilution method | |||
| AID1221960 | Apparent permeability from apical to basolateral side of human Caco2 cells at 10 uM up to 120 mins by HPLC-MC analysis in presence of 1 uM of P-gp inhibitor LY335979 | 2011 | Drug metabolism and disposition: the biological fate of chemicals, Feb, Volume: 39, Issue:2 | Attenuation of intestinal absorption by major efflux transporters: quantitative tools and strategies using a Caco-2 model. |
| AID278383 | Antifungal activity against Candida lusitaniae 6936 URA3[D95V] derived null mutant fur1delta::URA3 by microdilution assay | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Molecular mechanism of flucytosine resistance in Candida lusitaniae: contribution of the FCY2, FCY1, and FUR1 genes to 5-fluorouracil and fluconazole cross-resistance. |
| AID1392817 | Inhibition of Cyp51 in Candida albicans ATCC SC5314 assessed as obtusifoliol content at 0.03125 ug/ml after 16 hrs by GC-MS analysis (Rvb = 0.6%) | 2018 | Bioorganic & medicinal chemistry, 07-23, Volume: 26, Issue:12 | Design, synthesis and evaluation of benzoheterocycle analogues as potent antifungal agents targeting CYP51. |
| AID1634358 | Antifungal activity against Candida albicans CPCC 400523 assessed as inhibition of visible microbe growth by broth microdilution method | 2019 | Bioorganic & medicinal chemistry letters, 09-01, Volume: 29, Issue:17 | Design, synthesis and evaluation of biphenyl imidazole analogues as potent antifungal agents. |
| AID1864950 | Antiinflammatory activity against mouse infected with Candida albicans ATCC SC5314 assessed as reduction in COX-2 expression in spleen in presence of naproxen by Western blot analysis | |||
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| AID1742149 | Inhibition of CYP51 in Candida albicans ATCC SC5314 assessed as unidentified sterol level at 4 ug/ml incubated for 16 hrs by LC/MS analysis (Rvb = 7.03 %) | 2020 | European journal of medicinal chemistry, Nov-01, Volume: 205 | Design, synthesis and bioactivity evaluation of novel arylalkene-amide derivatives as dual-target antifungal inhibitors. |
| AID1872521 | Antifungal activity against Aspergillus fumigatus SANK 10569 by 96-well microplate method | 2022 | European journal of medicinal chemistry, Mar-05, Volume: 231 | Synthetic approaches and structural diversity of triazolylbutanols derived from voriconazole in the antifungal drug development. |
| AID1758003 | Antifungal activity against Candida zeylanoides CMGCC2.3739 measured after 24 hrs by broth microdilution assay | 2021 | European journal of medicinal chemistry, Apr-15, Volume: 216 | Lead optimization generates selenium-containing miconazole CYP51 inhibitors with improved pharmacological profile for the treatment of fungal infections. |
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| AID1903351 | Antifungal activity against Aspergillus fumigatus GIMCC 3.19 assessed as reduction in fungal growth incubated for 24 hrs by two fold broth dilution method | 2022 | European journal of medicinal chemistry, Apr-05, Volume: 233 | Design, synthesis, and biological evaluation of novel spiro[pyrrolidine-2,3'-quinolin]-2'-one derivatives as potential chitin synthase inhibitors and antifungal agents. |
| AID369394 | Antimicrobial activity against Pichia ohmeri isolate | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | In vitro susceptibility to posaconazole of 1,903 yeast isolates recovered in France from 2003 to 2006 and tested by the method of the European committee on antimicrobial susceptibility testing. |
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| AID1728519 | Inhibition of CYP51 in Candida albicans ATCC SC5314 assessed as unknown sterol level at 0.5 ug/ml incubated for 48 hrs by LC/MS analysis | 2021 | European journal of medicinal chemistry, Jan-15, Volume: 210 | Novel naphthylamide derivatives as dual-target antifungal inhibitors: Design, synthesis and biological evaluation. |
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| AID775729 | Antifungal activity against Aspergillus fumigatus assessed as growth inhibition after 48 to 72 hrs by broth microdilution method | 2013 | European journal of medicinal chemistry, Nov, Volume: 69 | Microwave assisted synthesis of dihydrobenzo[4,5]imidazo[1,2-a]pyrimidin-4-ones; synthesis, in vitro antimicrobial and anticancer activities of novel coumarin substituted dihydrobenzo[4,5]imidazo[1,2-a]pyrimidin-4-ones. |
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| AID1507061 | Antifungal activity against Candida mycoderma after 24 hrs by NCCLS two fold broth microdilution method | 2017 | European journal of medicinal chemistry, Aug-18, Volume: 136 | Design, synthesis and antimicrobial evaluation of novel benzimidazole-incorporated sulfonamide analogues. |
| AID490316 | Antimicrobial activity against Pseudomonas aeruginosa ATCC 278533 at 4 ug/disk by disk diffusion method | 2010 | European journal of medicinal chemistry, Jul, Volume: 45, Issue:7 | Synthesis and biological evaluation of some thio containing pyrrolo [2,3-d]pyrimidine derivatives for their anti-inflammatory and anti-microbial activities. |
| AID1392813 | Inhibition of Cyp51 in Candida albicans ATCC SC5314 assessed as ergosterol content at 0.125 ug/ml after 16 hrs by GC-MS analysis (Rvb = 98.7%) | 2018 | Bioorganic & medicinal chemistry, 07-23, Volume: 26, Issue:12 | Design, synthesis and evaluation of benzoheterocycle analogues as potent antifungal agents targeting CYP51. |
| AID584412 | Antifungal activity against 2 days cultured Candida tropicalis isolated from neutropenic subject with AML or MDS pharynx receiving antifungal therapy for 45 days after 24 days of prophylaxis by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Impact of antifungal prophylaxis on colonization and azole susceptibility of Candida species. |
| AID1898185 | Induction of drug resistance in Candida albicans SC5314 assessed as increase in MIC after 2 weeks (Rvb = 0.5 microg/ml) | |||
| AID1279033 | Antifungal activity against Trichophyton mentagrophytes 445 after 72 hrs by microbroth dilution method | 2016 | Bioorganic & medicinal chemistry, Mar-15, Volume: 24, Issue:6 | Salicylanilide N-monosubstituted carbamates: Synthesis and in vitro antimicrobial activity. |
| AID655586 | Antifungal activity against Trichophyton rubrum by microbroth dilution method | 2012 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 22, Issue:8 | New triazole derivatives as antifungal agents: synthesis via click reaction, in vitro evaluation and molecular docking studies. |
| AID1707487 | Antifungal activity against Candida albicans 4108 incubated for 48 hrs by microdilution assay | 2021 | Journal of medicinal chemistry, 01-28, Volume: 64, Issue:2 | Novel Carboline Fungal Histone Deacetylase (HDAC) Inhibitors for Combinational Treatment of Azole-Resistant Candidiasis. |
| AID675305 | Antibacterial activity against Escherichia coli JM109 by two fold broth dilution method | 2012 | Bioorganic & medicinal chemistry letters, Sep-01, Volume: 22, Issue:17 | Design, synthesis and evaluation of clinafloxacin triazole hybrids as a new type of antibacterial and antifungal agents. |
| AID1394708 | Antifungal activity against fluconazole-resistant Candida albicans TTSH-CALB02 after overnight incubation by CLSI broth microdilution method | 2018 | European journal of medicinal chemistry, Apr-25, Volume: 150 | Structure-activity relationship studies of ultra-short peptides with potent activities against fluconazole-resistant Candida albicans. |
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| AID469171 | Antifungal activity against Aspergillus flavus | 2010 | European journal of medicinal chemistry, Feb, Volume: 45, Issue:2 | Synthesis, anti-bacterial and anti-fungal activities of some novel Schiff bases containing 2,4-disubstituted thiazole ring. |
| AID1904362 | Antifungal activity against Candida krusei GIM 2.1 assessed as fungal growth inhibition by CLSI based serial microbroth dilution method | 2022 | European journal of medicinal chemistry, Apr-05, Volume: 233 | Design, synthesis, and evaluation of novel 3-thiophene derivatives as potent fungistatic and fungicidal reagents based on a conformational restriction strategy. |
| AID1904360 | Antifungal activity against Candida parapsilosis GIM 2.190 assessed as fungal growth inhibition by CLSI based serial microbroth dilution method | 2022 | European journal of medicinal chemistry, Apr-05, Volume: 233 | Design, synthesis, and evaluation of novel 3-thiophene derivatives as potent fungistatic and fungicidal reagents based on a conformational restriction strategy. |
| AID1918332 | Antifungal activity against Candida albicans ATCC SC5314 assessed as inhibition of fungal growth measured after 72 hrs by CLSI based liquid medium dilution method | 2022 | Journal of medicinal chemistry, 11-10, Volume: 65, Issue:21 | Novel Aryl Alkamidazole Derivatives as Multifunctional Antifungal Inhibitors: Design, Synthesis, and Biological Evaluation. |
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| AID285696 | Serum trough levels in Wistar rat pup at 10 mg/kg of body weight/day, ip after 72 hrs by ELISA | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Neonatal coinfection model of coagulase-negative Staphylococcus (Staphylococcus epidermidis) and Candida albicans: fluconazole prophylaxis enhances survival and growth. |
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| AID420078 | Antifungal activity against Cryptococcus neoformans CAP67 after 24 hrs by broth microdilution assay | 2009 | Bioorganic & medicinal chemistry, Jun-01, Volume: 17, Issue:11 | Bulky 1,4-benzoxazine derivatives with antifungal activity. |
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| AID1557082 | Antifungal activity against Candida parapsilosis ATCC 22019 assessed as reduction in fungal cell growth incubated for 24 hrs by MTT based broth double dilution method | 2019 | European journal of medicinal chemistry, Oct-01, Volume: 179 | Antifungal activity, mode of action variability, and subcellular distribution of coumarin-based antifungal azoles. |
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| AID1193500 | Thermodynamic equilibrium solubility, log S of the compound | 2015 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 25, Issue:7 | Thermodynamic equilibrium solubility measurements in simulated fluids by 96-well plate method in early drug discovery. |
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| AID424881 | Antimicrobial activity against azole-resistant Candida albicans isolate CA10 assessed as growth at 2 ug/ml co-treated with 0.031 ug/ml calcineurin signaling inhibitor tacrolimus after 48 hrs by microdilution checkboard technique relative to control | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | In vitro interactions between tacrolimus and azoles against Candida albicans determined by different methods. |
| AID1334858 | Inhibition of Candida albicans SC5314 CYP51 assessed as change in total sterol composition at 8 ug/ml by GC-MS method (Rvb = 7.1 %) | 2017 | Bioorganic & medicinal chemistry, 01-15, Volume: 25, Issue:2 | Discovery of biphenyl imidazole derivatives as potent antifungal agents: Design, synthesis, and structure-activity relationship studies. |
| AID638564 | Antifungal activity against Candida krusei Berkout KCCM 11655 after 1 day by two fold broth dilution method | 2012 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 22, Issue:1 | Synthesis and antifungal evaluation of pyrido[1,2-a]indole-1,4-diones and benzo[f]pyrido[1,2-a]indole-6,11-diones. |
| AID407053 | Antimicrobial activity against Candida albicans SC5314 at 512 ug/ml at planktonic cell density of 5 x 10'7 cells/ml after 48 hrs by XTT assay | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | Role for cell density in antifungal drug resistance in Candida albicans biofilms. |
| AID553534 | Drug accumulation in Saccharomyces cerevisiae AD12345678 reenergized with glucose at pH 6.0 assessed as intracellular accumulation after 60 mins by fluorescamine staining | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | Enhanced susceptibility to antifungal oligopeptides in yeast strains overexpressing ABC multidrug efflux pumps. |
| AID584590 | Antifungal activity against 43 days cultured Candida glabrata isolated from HSCT recipient with acute or chronic GVHD mouth receiving antifungal therapy for 168 days after 113 days of prophylaxis by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Impact of antifungal prophylaxis on colonization and azole susceptibility of Candida species. |
| AID1864961 | Immunostimulatory activity in mouse infected with Candida albicans ATCC SC5314 assessed as increase in CD3+ expression level in spleen by immunohistochemical analysis | |||
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| AID549047 | Antifungal activity against Candida albicans CA4 after 48 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | In vitro activities of retigeric acid B alone and in combination with azole antifungal agents against Candida albicans. |
| AID1254326 | Antifungal activity against Absidia corymbifera 272 after 24 hrs by microdilution broth method | 2015 | Bioorganic & medicinal chemistry, Nov-15, Volume: 23, Issue:22 | Novel derivatives of nitro-substituted salicylic acids: Synthesis, antimicrobial activity and cytotoxicity. |
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| AID598299 | Antimicrobial activity against Candida parapsilosis isolate 19 after 48 hrs by microdilution broth method | 2011 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 21, Issue:11 | Synthesis and in vitro antimicrobial activities of new (cyano-NNO-azoxy)pyrazole derivatives. |
| AID1762164 | Antifungal activity against Aspergillus niger 37a assessed as reduction in fungal growth incubated for 24 hrs by CLSI based serial microbroth dilution method | 2021 | Bioorganic & medicinal chemistry letters, 05-15, Volume: 40 | Synthesis and antifungal activity of new hybrids thiazolo[4,5-d]pyrimidines with (1H-1,2,4)triazole. |
| AID301018 | Antifungal activity against Candida albicans at 250 ug/ml after 48 hrs by agar well diffusion technique | 2007 | Bioorganic & medicinal chemistry letters, Oct-01, Volume: 17, Issue:19 | Synthesis and antimicrobial evaluation of new chalcones containing piperazine or 2,5-dichlorothiophene moiety. |
| AID1738715 | Inhibition of CYP51 in azole-resistant Candida albicans ATCC SC531 assessed as ergosterol level at 0.03125 ug/ml incubated for 16 hrs by LC-MS analysis relative to control | 2020 | European journal of medicinal chemistry, Jul-15, Volume: 198 | Design, synthesis, and biological evaluation of novel miconazole analogues containing selenium as potent antifungal agents. |
| AID531240 | Antifungal activity against Candida albicans assessed as susceptible isolates after 48 hrs by CLSI method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | In vitro susceptibilities of invasive isolates of Candida species: rapid increase in rates of fluconazole susceptible-dose dependent Candida glabrata isolates. |
| AID325039 | Ratio of MIC for Candida albicans P5 mutant to MIC for Candida albicans SC5314 | 2007 | Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5 | A Candida albicans petite mutant strain with uncoupled oxidative phosphorylation overexpresses MDR1 and has diminished susceptibility to fluconazole and voriconazole. |
| AID1822497 | Antifungal activity against Candida albicans SN152 harbouring erg3delta delta/erg11delta delta assessed as Cyp51-mediated fungal growth inhibition at 1 to 64 ug/mL measured every 40 mins for 48 hrs by double dilution method | 2022 | Journal of medicinal chemistry, 02-10, Volume: 65, Issue:3 | Fluconazole-COX Inhibitor Hybrids: A Dual-Acting Class of Antifungal Azoles. |
| AID464674 | Antifungal activity against Aspergillus fumigatus after 48 to 72 hrs by broth microdilution method | 2010 | European journal of medicinal chemistry, Mar, Volume: 45, Issue:3 | Synthesis and antimicrobial studies on novel sulfonamides containing 4-azidomethyl coumarin. |
| AID462242 | Antifungal activity against Candida albicans SA40 infected in Wistar rat estrogen-dependent fungal vaginitis model assessed as fungal burden at 10 ug administered intravaginally 1 hr after fungal infection measured on day 1 after infection | 2010 | Journal of medicinal chemistry, Mar-25, Volume: 53, Issue:6 | Identification of inhibitors of drug-resistant Candida albicans strains from a library of bicyclic peptidomimetic compounds. |
| AID1370742 | Antifungal activity against Microsporum gypseum by serial dilution method | 2018 | Bioorganic & medicinal chemistry letters, 02-01, Volume: 28, Issue:3 | Design, synthesis, and structure-activity relationship studies of novel tetrazole antifungal agents with potent activity, broad antifungal spectrum and high selectivity. |
| AID515329 | Antifungal activity against Candida albicans ATCC 76615 by twofold serial dilution technique | 2010 | European journal of medicinal chemistry, Oct, Volume: 45, Issue:10 | Synthesis of novel sulfanilamide-derived 1,2,3-triazoles and their evaluation for antibacterial and antifungal activities. |
| AID1369466 | Fungicidal activity against Candida tropicalis cgmcc 2.1975 after 96 hrs | 2018 | Journal of medicinal chemistry, 05-10, Volume: 61, Issue:9 | Combating Drug-Resistant Fungi with Novel Imperfectly Amphipathic Palindromic Peptides. |
| AID1408107 | Antibacterial activity against Pseudomonas aeruginosa PAO1 after 24 hrs by two-fold serial dilution method | 2018 | European journal of medicinal chemistry, Sep-05, Volume: 157 | Design, synthesis, antimicrobial, antiquorum-sensing and antitumor evaluation of new series of pyrazolopyridine derivatives. |
| AID405066 | Antifungal activity against Candida krusei ATCC 6258 isolate from cutaneous-lymphatic sporotrichosis patient after 72 hrs by modified NCCLS M38-A method | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | In vitro susceptibility of Sporothrix schenckii to six antifungal agents determined using three different methods. |
| AID47894 | Minimal inhibitory effect against the Candida parapsilosis (2372E). | 2002 | Bioorganic & medicinal chemistry letters, Jul-08, Volume: 12, Issue:13 | Antifungal Sordarins. Part 4: synthesis and structure--activity relationships of 3',4'-fused alkyl-tetrahydrofuran derivatives. |
| AID554713 | Antimicrobial activity against Candida krusei NZCDC 89.021 after 48 hrs by CLSI method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Abc1p is a multidrug efflux transporter that tips the balance in favor of innate azole resistance in Candida krusei. |
| AID1235459 | Antifungal activity against clinical isolates of Candida albicans 2323 after 48 hrs by disc diffusion assay | 2015 | Bioorganic & medicinal chemistry, Aug-01, Volume: 23, Issue:15 | Imidazole clubbed 1,3,4-oxadiazole derivatives as potential antifungal agents. |
| AID565075 | Antimicrobial activity against Blastoschizomyces capitatus by microdilution method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Case of fatal Blastoschizomyces capitatus infection occurring in a patient receiving empiric micafungin therapy. |
| AID1055721 | Antifungal activity against Candida tropicalis after 24 to 48 hrs by agar well diffusion method | 2013 | European journal of medicinal chemistry, , Volume: 70 | Solution-phase microwave assisted parallel synthesis of N,N'-disubstituted thioureas derived from benzoic acid: biological evaluation and molecular docking studies. |
| AID1592219 | Antifungal activity against fluconazole-resistant Candida albicans 100 assessed as inhibition of microbial growth by NCCLS protocol based method | 2019 | Bioorganic & medicinal chemistry, 06-15, Volume: 27, Issue:12 | Design, synthesis and biological evaluation of amide-pyridine derivatives as novel dual-target (SE, CYP51) antifungal inhibitors. |
| AID448162 | Antimicrobial activity against Candida tropicalis ATCC 13803 at 5 ug after 18 hrs by well diffusion method | 2009 | European journal of medicinal chemistry, Nov, Volume: 44, Issue:11 | Synthesis of some new 1,2,4-triazoles starting from isonicotinic acid hydrazide and evaluation of their antimicrobial activities. |
| AID1430410 | Antifungal activity against Candida glabrata H05 after 24 to 48 hrs by macro-broth dilution method | 2017 | Bioorganic & medicinal chemistry letters, 03-01, Volume: 27, Issue:5 | Methylsulfonyl benzothiazoles (MSBT) derivatives: Search for new potential antimicrobial and anticancer agents. |
| AID1885989 | Antifungal activity against Cryptococcus neoformans clinical isolate HN1 assessed as fungal growth inhibition incubated for 72 hrs in presence of P163-0892 by broth microdilution method | |||
| AID1168336 | Binding affinity to human serum albumin by spectroscopy in presence of Mn2+ | 2014 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 24, Issue:21 | Study the interactions between human serum albumin and two antifungal drugs: fluconazole and its analogue DTP. |
| AID1491339 | Antibacterial activity against Escherichia coli ATCC 12435 after 24 hrs by two-fold serial dilution method | 2017 | European journal of medicinal chemistry, Sep-08, Volume: 137 | Synthesis, antimicrobial, antiquorum-sensing and antitumor activities of new benzimidazole analogs. |
| AID1474176 | Inhibition of CYP51 in Candida albicans ATCC SC5314 assessed as obtusifoliol composition of the total sterol fraction in membrane at 8 ug/ml after 16 hrs by GC-MS analysis relative to control | 2016 | European journal of medicinal chemistry, Nov-10, Volume: 123 | Design, synthesis, and structure-activity relationship studies of benzothiazole derivatives as antifungal agents. |
| AID1507064 | Antifungal activity against Aspergillus flavus after 24 hrs by NCCLS two fold broth microdilution method | 2017 | European journal of medicinal chemistry, Aug-18, Volume: 136 | Design, synthesis and antimicrobial evaluation of novel benzimidazole-incorporated sulfonamide analogues. |
| AID1535348 | Antifungal activity against Candida albicans NCIM 3471 after 48 to 72 hrs by SDA agar dilution method | 2019 | Bioorganic & medicinal chemistry letters, 02-15, Volume: 29, Issue:4 | Synthesis, biological evaluations and computational studies of N-(3-(-2-(7-Chloroquinolin-2-yl)vinyl) benzylidene)anilines as fungal biofilm inhibitors. |
| AID603898 | Antifungal activity against Candida albicans MTCC 4748 after 18 hrs by microtiter broth dilution method | 2011 | European journal of medicinal chemistry, Jul, Volume: 46, Issue:7 | Total synthesis of racemic and (R) and (S)-4-methoxyalkanoic acids and their antifungal activity. |
| AID464673 | Antifungal activity against Candida albicans after 48 to 72 hrs by broth microdilution method | 2010 | European journal of medicinal chemistry, Mar, Volume: 45, Issue:3 | Synthesis and antimicrobial studies on novel sulfonamides containing 4-azidomethyl coumarin. |
| AID762388 | Antifungal activity against Candida albicans ATCC 10231 after 24 to 72 hrs by microdilution method | 2013 | European journal of medicinal chemistry, Aug, Volume: 66 | Synthesis, in vitro antifungal activity and in silico study of 3-(1,2,4-triazol-1-yl)flavanones. |
| AID1543204 | Antimicrobial activity against Candida albicans ATCC 10231 assessed as inhibition of microbial growth incubated for 16 hrs by broth microdilution method | |||
| AID581869 | Antifungal activity against Candida glabrata isolated from neutropenic subject 1102 with AML or MDS stool receiving antifungal drug after 26 days prophylaxis by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Impact of antifungal prophylaxis on colonization and azole susceptibility of Candida species. |
| AID118076 | In vivo evaluation of % survival rate after peroral administration on 9th day at dose 5 mg/kg | 1995 | Journal of medicinal chemistry, Sep-29, Volume: 38, Issue:20 | Synthesis and antifungal activity of new azole derivatives containing an N-acylmorpholine ring. |
| AID1419532 | Hemolytic activity in mouse erythrocytes assessed as hemolysis level at 1.95 ug/ml incubated for 1 hr at 37 degC | 2017 | European journal of medicinal chemistry, Jun-16, Volume: 133 | Novel alkylated azoles as potent antifungals. |
| AID465556 | Antifungal activity against Candida parapsilosis by NCCLS broth microdilution method | 2010 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 20, Issue:5 | Stereospecific synthesis of oximes and oxime ethers of 3-azabicycles: A SAR study towards antimicrobial agents. |
| AID48571 | Minimum concentration required to inhibit the growth of Candida albicans SANK51486 was determined | 2002 | Bioorganic & medicinal chemistry letters, Oct-07, Volume: 12, Issue:19 | Synthesis and evaluation of novel pyrrolidinyl sordaricin derivatives as antifungal agents. |
| AID737324 | Antimicrobial activity against Aspergillus oryzae MTCC 3567 at 750 ug/ml after 72 hrs by cup plate method | 2013 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 23, Issue:7 | Synthesis of novel 2-amino-4-(5'-substituted 2'-phenyl-1H-indol-3'-yl)-6-aryl-4H-pyran-3-carbonitrile derivatives as antimicrobial and antioxidant agents. |
| AID736602 | Antifungal activity against voriconazole-resistant Candida glabrata clinical isolate 730 assessed as growth inhibition after 24 to 48 hrs by CLSI microbroth dilution method | 2013 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 23, Issue:6 | Synthesis and anti-Candida activity of novel 2-hydrazino-1,3-thiazole derivatives. |
| AID1426257 | Antifungal activity against azole-susceptible Candida albicans MYA2876 | 2017 | European journal of medicinal chemistry, Jan-27, Volume: 126 | Synthesis and bioactivity investigation of quinone-based dimeric cationic triazolium amphiphiles selective against resistant fungal and bacterial pathogens. |
| AID518873 | Antimicrobial activity against Cryptococcus gattii serotype C isolate H0058-1-2023 assessed as heteroresistant isolates at 16 ug/ml | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Heteroresistance of Cryptococcus gattii to fluconazole. |
| AID575752 | Antimicrobial activity against Aspergillus fumigatus CEA10 | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10 | Expression, purification, and characterization of Aspergillus fumigatus sterol 14-alpha demethylase (CYP51) isoenzymes A and B. |
| AID1610304 | Antifungal activity against Cryptococcus neoformans CGMCC2.3161 measured at 72 hrs by CLSI protocol based microbroth dilution method | 2019 | Bioorganic & medicinal chemistry letters, 12-01, Volume: 29, Issue:23 | Design, synthesis and biological evaluation of novel semicarbazone-selenochroman-4-ones hybrids as potent antifungal agents. |
| AID279095 | Ratio of AUC in candidemia patient to MIC against Candida lusitaniae | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Association of fluconazole area under the concentration-time curve/MIC and dose/MIC ratios with mortality in nonneutropenic patients with candidemia. |
| AID518693 | Antimicrobial activity against Cryptococcus gattii serotype B isolate RB14 assessed as heteroresistant isolates at 16 ug/ml | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Heteroresistance of Cryptococcus gattii to fluconazole. |
| AID495352 | Antimicrobial activity against fluconazole resistant Candida albicans isolate 3795 expressing high levels of ERG11 and UPC2 mRNA by microdilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | An A643T mutation in the transcription factor Upc2p causes constitutive ERG11 upregulation and increased fluconazole resistance in Candida albicans. |
| AID518458 | Antimicrobial activity against Cryptococcus gattii serotype C isolate NIH191 assessed as heteroresistant isolates at 4 ug/ml | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Heteroresistance of Cryptococcus gattii to fluconazole. |
| AID302123 | Antifungal activity against fluconazole-resistant Candida albicans 01010 after 24 hrs | 2007 | Journal of medicinal chemistry, Nov-01, Volume: 50, Issue:22 | Synthesis and antifungal activities of novel 2-aminotetralin derivatives. |
| AID1079935 | Cytolytic liver toxicity, either proven histopathologically or where the ratio of maximal ALT or AST activity above normal to that of Alkaline Phosphatase is > 5 (see ACUTE). Value is number of references indexed. [column 'CYTOL' in source] | |||
| AID1487496 | Antifungal activity against Candida albicans assessed as zone of inhibition at 100 ug/ml measured after 24 hrs by well diffusion method | 2017 | Bioorganic & medicinal chemistry letters, 08-15, Volume: 27, Issue:16 | Synthesis, antioxidant, antifungal, molecular docking and ADMET studies of some thiazolyl hydrazones. |
| AID518163 | Antimicrobial activity against Cryptococcus gattii serotype C isolate NIH917 assessed as concentration required for heteroresistance | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Heteroresistance of Cryptococcus gattii to fluconazole. |
| AID582802 | Antifungal activity against Candida albicans isolate 1008 harboring ERG3 K97E, L193P, V237A, A351V, A353T and ERG11 E266D mutant genes by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | Identification and characterization of four azole-resistant erg3 mutants of Candida albicans. |
| AID681137 | TP_TRANSPORTER: increase in Calcein-AM intracellular accumulation in mdr1a-expressing LLC-PK1 cells | 2002 | The Journal of pharmacology and experimental therapeutics, Oct, Volume: 303, Issue:1 | Interaction of cytochrome P450 3A inhibitors with P-glycoprotein. |
| AID1079944 | Benign tumor, proven histopathologically. Value is number of references indexed. [column 'T.BEN' in source] | |||
| AID1738718 | Inhibition of CYP51 in azole-resistant Candida albicans ATCC SC531 assessed as ergosterol level at 2 ug/ml incubated for 16 hrs by LC-MS analysis relative to control | 2020 | European journal of medicinal chemistry, Jul-15, Volume: 198 | Design, synthesis, and biological evaluation of novel miconazole analogues containing selenium as potent antifungal agents. |
| AID428423 | Antifungal activity against Epidermophyton floccosum after 48 hrs by agar dilution method | 2009 | European journal of medicinal chemistry, Jul, Volume: 44, Issue:7 | Design, synthesis, and antifungal activity of triazole and benzotriazole derivatives. |
| AID1392831 | Inhibition of Cyp51 in Candida albicans ATCC SC5314 assessed as 4,4-dimethyl zymosterol content at 2 ug/ml after 16 hrs by GC-MS analysis relative to control | 2018 | Bioorganic & medicinal chemistry, 07-23, Volume: 26, Issue:12 | Design, synthesis and evaluation of benzoheterocycle analogues as potent antifungal agents targeting CYP51. |
| AID1888416 | Inhibition of fungal filamentation in azole-resistant Candida albicans 0304103 assessed as reduction in yeast-hypha transition at 64 ug/ml by inverted microscopic analysis | 2022 | European journal of medicinal chemistry, Jan-05, Volume: 227 | Heat shock protein 90 (Hsp90)/Histone deacetylase (HDAC) dual inhibitors for the treatment of azoles-resistant Candida albicans. |
| AID546074 | Antifungal activity against Candida dubliniensis isolated from candidemia patient by AFST-EUCAST microdilution method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | A 10-year survey of antifungal susceptibility of candidemia isolates from intensive care unit patients in Greece. |
| AID518884 | Antimicrobial activity against Cryptococcus gattii serotype B isolate RAM15 assessed as heteroresistant isolates at 32 ug/ml | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Heteroresistance of Cryptococcus gattii to fluconazole. |
| AID561422 | Antifungal activity against fcy1(1-119)-deficient Candida lusitaniae by microdilution method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Nonsense and missense mutations in FCY2 and FCY1 genes are responsible for flucytosine resistance and flucytosine-fluconazole cross-resistance in clinical isolates of Candida lusitaniae. |
| AID1743169 | Antifungal activity against Trichophyton violaceum | 2020 | European journal of medicinal chemistry, Dec-15, Volume: 208 | Multiple biological active 4-aminopyrazoles containing trifluoromethyl and their 4-nitroso-precursors: Synthesis and evaluation. |
| AID1783073 | Antifungal activity against fluconazole-sensitive Cryptococcus neoformans H99 assessed as inhibition of cell proliferation at 2 to 8 ug/ml measured for 48 hrs by time growth curve assay | 2021 | European journal of medicinal chemistry, Oct-05, Volume: 221 | Lanosterol 14α-demethylase (CYP51)/histone deacetylase (HDAC) dual inhibitors for treatment of Candida tropicalis and Cryptococcus neoformans infections. |
| AID1903349 | Antifungal activity against Candida albicans ATCC 76615 assessed as reduction in fungal growth incubated for 24 hrs by two fold broth dilution method | 2022 | European journal of medicinal chemistry, Apr-05, Volume: 233 | Design, synthesis, and biological evaluation of novel spiro[pyrrolidine-2,3'-quinolin]-2'-one derivatives as potential chitin synthase inhibitors and antifungal agents. |
| AID1309048 | Antifungal activity against Candida albicans ATCC MYA-2876 after 48 hrs by CLSI M27-A3 method | 2016 | Bioorganic & medicinal chemistry, 08-15, Volume: 24, Issue:16 | Synthesis and investigation of novel benzimidazole derivatives as antifungal agents. |
| AID274121 | Antifungal activity against Candida albicans after 24 hrs | 2006 | Bioorganic & medicinal chemistry letters, Oct-15, Volume: 16, Issue:20 | Design, synthesis, and antifungal activities in vitro of novel tetrahydroisoquinoline compounds based on the structure of lanosterol 14alpha-demethylase (CYP51) of fungi. |
| AID522124 | Fungicidal activity against Candida glabrata TG162 containing calcineurin deltacnb1 mutant assessed as reduction in bacterial cell viability by time kill study | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Roles of calcineurin and Crz1 in antifungal susceptibility and virulence of Candida glabrata. |
| AID1585638 | Antifungal activity against Candida parapsilosis ATCC 22019 cultured in YNB media after 24 hrs by broth microdilution method | 2019 | European journal of medicinal chemistry, Jan-15, Volume: 162 | Chemical preparation, biological evaluation and 3D-QSAR of ethoxysulfuron derivatives as novel antifungal agents targeting acetohydroxyacid synthase. |
| AID405042 | Antifungal activity against Sporothrix schenckii P1621 isolate from cutaneous-lymphatic sporotrichosis patient after 72 hrs by modified NCCLS M38-A method | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | In vitro susceptibility of Sporothrix schenckii to six antifungal agents determined using three different methods. |
| AID584405 | Antifungal activity against 23 days cultured Candida glabrata isolated from neutropenic subject with AML or MDS stool receiving antifungal therapy for 25 days after 3 days of prophylaxis by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Impact of antifungal prophylaxis on colonization and azole susceptibility of Candida species. |
| AID465557 | Antifungal activity against Aspergillus niger by NCCLS broth microdilution method | 2010 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 20, Issue:5 | Stereospecific synthesis of oximes and oxime ethers of 3-azabicycles: A SAR study towards antimicrobial agents. |
| AID1497600 | Antifungal activity against fluconazole-resistant Candida albicans isolate 117 after 24 hrs by broth microdilution method | 2018 | Bioorganic & medicinal chemistry letters, 07-15, Volume: 28, Issue:13 | Benzofuro[3,2-d]pyrimidines inspired from cercosporamide CaPkc1 inhibitor: Synthesis and evaluation of fluconazole susceptibility restoration. |
| AID1212341 | Cytotoxicity against human Fa2N-4 cells by lactate dehydrogenase assay | 2013 | Drug metabolism and disposition: the biological fate of chemicals, Apr, Volume: 41, Issue:4 | Lysosomal sequestration (trapping) of lipophilic amine (cationic amphiphilic) drugs in immortalized human hepatocytes (Fa2N-4 cells). |
| AID1394703 | Antifungal activity against fluconazole-resistant Candida albicans ATCC 64124 after overnight incubation by CLSI broth microdilution method | 2018 | European journal of medicinal chemistry, Apr-25, Volume: 150 | Structure-activity relationship studies of ultra-short peptides with potent activities against fluconazole-resistant Candida albicans. |
| AID1584740 | Drug metabolism in rat liver microsome S9 fraction assessed as CYP450-mediated metabolism by measuring compound remaining at 5 uM pretreated with NADPH and measured after 15 mins by UPLC-MS/MS analysis | 2018 | Journal of medicinal chemistry, 10-25, Volume: 61, Issue:20 | Discovery of Novel 7-Aryl 7-Deazapurine 3'-Deoxy-ribofuranosyl Nucleosides with Potent Activity against Trypanosoma cruzi. |
| AID642934 | Antifungal activity against intrinsically fluconazole-resistant Candida glabrata ATCC 90030 at 160 ug/ml | 2011 | ACS medicinal chemistry letters, May-12, Volume: 2, Issue:5 | Natural Product Based 6-Hydroxy-2,3,4,6-tetrahydropyrrolo[1,2-a]pyrimidinium Scaffold as A New Antifungal Template. |
| AID1624169 | Antifungal activity against Candida albicans NR-29435 after 24 hrs by microbroth dilution method | 2019 | Bioorganic & medicinal chemistry letters, 03-01, Volume: 29, Issue:5 | Benzimidazole tethered pyrrolo[3,4-b]quinoline with broad-spectrum activity against fungal pathogens. |
| AID1628390 | Antimicrobial activity against Aspergillus flavus ATCC 204304 incubated for 24 hrs by NCCLS protocol based method | 2016 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 26, Issue:12 | Discovery of novel berberine imidazoles as safe antimicrobial agents by down regulating ROS generation. |
| AID493521 | Antifungal activity against Aspergillus fumigatus 231 after 24 hrs by broth microdilution assay | 2010 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 20, Issue:15 | N-Benzylsalicylthioamides as novel compounds with promising antimycotic activity. |
| AID1157167 | Antifungal activity against Cryptococcus neoformans PMC 2107 after 72 hrs by CLSI broth microdilution method | 2014 | European journal of medicinal chemistry, Aug-18, Volume: 83 | Synthesis, biological evaluation and structure-activity correlation study of a series of imidazol-based compounds as Candida albicans inhibitors. |
| AID1689233 | Antibiofilm activity against Candida albicans NR29448 assessed as reduction in biofilm formation at 0.5XMIC incubated for 24 hrs by crystal violet staining based assay relative to control | 2020 | European journal of medicinal chemistry, Mar-01, Volume: 189 | Oxadiazolylthiazoles as novel and selective antifungal agents. |
| AID478534 | Antimicrobial activity against Aspergillus niger ATCC 6275 after 24 hrs by broth microdilution assay | 2010 | European journal of medicinal chemistry, May, Volume: 45, Issue:5 | Synthesis of some novel 2-substituted-5-[isopropylthiazole] clubbed 1,2,4-triazole and 1,3,4-oxadiazoles as potential antimicrobial and antitubercular agents. |
| AID1201629 | Antimicrobial activity against Aspergillus fumigatus ATCC 1022 assessed as diameter of zone of inhibition at 20 microg/disc after 24 hrs by agar well diffusion method | 2015 | European journal of medicinal chemistry, May-05, Volume: 95 | Synthesis, biological evaluation and molecular docking of some substituted pyrazolines and isoxazolines as potential antimicrobial agents. |
| AID595001 | Antifungal activity against Trichophyton mentagrophytes after 48 hrs | 2011 | Bioorganic & medicinal chemistry letters, May-15, Volume: 21, Issue:10 | Thermal solvent-free synthesis of novel pyrazolyl chalcones and pyrazolines as potential antimicrobial agents. |
| AID516262 | Antimicrobial activity against Cryptococcus gattii serotype B isolate NIH653 assessed as concentration required for heteroresistance | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Heteroresistance of Cryptococcus gattii to fluconazole. |
| AID520856 | Antifungal activity against Cryptococcus neoformans YC-11 infected in BALB/c mouse assessed as reduction in fungal burden in brain at 80 mg/kg, iv qd for 5 days measured after 7 days of infection | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | Efficacy of SPK-843, a novel polyene antifungal, in a murine model of systemic cryptococcosis. |
| AID245572 | In vitro concentration required to inhibit 80% growth of Saccharomyces cerevisiae strain YEM172 (CDR1 over-expressed) after 48 h | 2004 | Bioorganic & medicinal chemistry letters, Oct-18, Volume: 14, Issue:20 | Quinazolinone-based fungal efflux pump inhibitors. Part 1: Discovery of an (N-methylpiperazine)-containing derivative with activity in clinically relevant Candida spp. |
| AID518659 | Antimicrobial activity against Cryptococcus gattii serotype B isolate NIH409 assessed as heteroresistant isolates at 8 ug/ml | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Heteroresistance of Cryptococcus gattii to fluconazole. |
| AID638556 | Antifungal activity against Candida albicans Berkout KCCM 50235 after 1 day by twofold broth dilution method | 2012 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 22, Issue:1 | Synthesis and antifungal activity of 6,7-bis(arylthio)-quinazoline-5,8-diones and furo[2,3-f]quinazolin-5-ols. |
| AID1918363 | Inhibition of CYP51 in Candida albicans ATCC SC5314 assessed as unknown sterol content at 4 ug/ml measured after 48 hrs by GC-MS analysis | 2022 | Journal of medicinal chemistry, 11-10, Volume: 65, Issue:21 | Novel Aryl Alkamidazole Derivatives as Multifunctional Antifungal Inhibitors: Design, Synthesis, and Biological Evaluation. |
| AID666850 | Antifungal activity against Penicillium sp. at 12.5 ug/ml after 72 hrs by well plate method | 2012 | European journal of medicinal chemistry, Aug, Volume: 54 | Synthesis, characterization and antimicrobial studies of some new quinoline incorporated benzimidazole derivatives. |
| AID1889452 | Antifungal activity against Candida albicans incubated for 24 hrs by microbroth dilution method | 2022 | Journal of natural products, 02-25, Volume: 85, Issue:2 | Tigliane Diterpenoids with Larvicidal, Antifungal, and α-Glucosidase Inhibitory Activities from |
| AID39830 | Minimum concentration required to inhibit the growth of Aspergillus fumigatus ATCC 26430 was determined | 2002 | Bioorganic & medicinal chemistry letters, Oct-07, Volume: 12, Issue:19 | Synthesis and evaluation of novel pyrrolidinyl sordaricin derivatives as antifungal agents. |
| AID302125 | Antifungal activity against fluconazole-resistant Candida albicans 25 after 24 hrs | 2007 | Journal of medicinal chemistry, Nov-01, Volume: 50, Issue:22 | Synthesis and antifungal activities of novel 2-aminotetralin derivatives. |
| AID1154854 | Antifungal activity against fluconazole-sensitive Candida albicans SC5314 assessed as change in sterol composition at 8 ug/ml after 24 hrs by GC-MS analysis (Rvb = 8.5%) | 2014 | ACS medicinal chemistry letters, May-08, Volume: 5, Issue:5 | Novel carboline derivatives as potent antifungal lead compounds: design, synthesis, and biological evaluation. |
| AID1193505 | Antifungal activity against Candida albicans PTCC 6027 after 24 to 168 hrs by broth microdilution assay | 2015 | Bioorganic & medicinal chemistry, Apr-01, Volume: 23, Issue:7 | Synthesis and biological evaluation of fluconazole analogs with triazole-modified scaffold as potent antifungal agents. |
| AID407022 | Antimicrobial activity against Chk1 deficient Candida albicans CHK21 intact biofilms after 48 hrs by XTT assay | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | Role for cell density in antifungal drug resistance in Candida albicans biofilms. |
| AID1419497 | Antifungal activity against ITC and FLC-susceptible Candida albicans ATCC MYA-2310 incubated for 48 hrs by modified CLSI M27-A3 protocol based method | 2017 | European journal of medicinal chemistry, Jun-16, Volume: 133 | Novel alkylated azoles as potent antifungals. |
| AID545467 | Antifungal activity against Trichophyton mentagrophytes after 48 hrs by broth microdilution method | 2010 | European journal of medicinal chemistry, Dec, Volume: 45, Issue:12 | New amino acid esters of salicylanilides active against MDR-TB and other microbes. |
| AID1224557 | Antifungal activity against Absidia corymbifera 272 after 24 hrs by broth microdilution method | 2014 | European journal of medicinal chemistry, Jul-23, Volume: 82 | 1-Substituted-5-[(3,5-dinitrobenzyl)sulfanyl]-1H-tetrazoles and their isosteric analogs: A new class of selective antitubercular agents active against drug-susceptible and multidrug-resistant mycobacteria. |
| AID477331 | Antifungal activity against Candida albicans ATCC 24433 at 30 ug/mL after 48 to 72 hrs by disk diffusion method | 2010 | European journal of medicinal chemistry, Apr, Volume: 45, Issue:4 | Synthesis and characterization of novel fatty acid analogs of cholesterol: in vitro antimicrobial activity. |
| AID582244 | Antifungal activity against Candida glabrata isolated from HSCT recipients with acute or chronic GVHD prior to initiation of fluconazole therapy assessed as maximum MIC by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Impact of antifungal prophylaxis on colonization and azole susceptibility of Candida species. |
| AID678716 | Inhibition of human CYP3A4 assessed as ratio of IC50 in absence of NADPH to IC50 for presence of NADPH using diethoxyfluorescein as substrate after 30 mins | 2012 | Chemical research in toxicology, Oct-15, Volume: 25, Issue:10 | Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds. |
| AID405016 | Antifungal activity against Sporothrix schenckii P25013 isolate from cutaneous-lymphatic sporotrichosis patient after 72 hrs by Sensititre YeastOne method | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | In vitro susceptibility of Sporothrix schenckii to six antifungal agents determined using three different methods. |
| AID1898177 | Antifungal activity against Candida auris BS12372 | |||
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| AID1152383 | Antimicrobial activity against Candida albicans after 48 hrs by broth microdilution method | 2014 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 24, Issue:12 | Synthesis, in vitro antimicrobial and cytotoxic activities of novel pyrimidine-benzimidazol combinations. |
| AID1246661 | Antifungal activity against Cryptococcus gattii L28/02 assessed as reduction in cell viability at 26 uM after 6 to 72 hrs by MTT assay | 2015 | European journal of medicinal chemistry, Sep-18, Volume: 102 | Thiazole compounds with activity against Cryptococcus gattii and Cryptococcus neoformans in vitro. |
| AID1770951 | Inhibition of CYP51 in Candida albicans assessed as ergosterol level at 0.25 ug/ml after 18 hrs by GC-MS analysis (Rvb = 96.93 %) | 2021 | European journal of medicinal chemistry, Dec-05, Volume: 225 | Design, synthesis and evaluation of novel 5-phenylthiophene derivatives as potent fungicidal of Candida albicans and antifungal reagents of fluconazole-resistant fungi. |
| AID1329220 | Antifungal activity against fluconazole-resistant Candida albicans clinical isolate 147 by CLSI broth microdilution method | 2016 | Journal of natural products, 09-23, Volume: 79, Issue:9 | Heptaketides from an Endolichenic Fungus Biatriospora sp. and Their Antifungal Activity. |
| AID1872519 | Antifungal activity against Candida albicans SANK 51486 by 96-well microplate method | 2022 | European journal of medicinal chemistry, Mar-05, Volume: 231 | Synthetic approaches and structural diversity of triazolylbutanols derived from voriconazole in the antifungal drug development. |
| AID1818269 | Antifungal activity against Candida albicans SC5314 assessed as reduction in fungal growth incubated for 72 hrs by CLSI protocol based broth microdilution method | |||
| AID606213 | Antifungal activity against Candida parapsilosis ATCC 0306392 by micro-broth dilution method | 2011 | European journal of medicinal chemistry, Jul, Volume: 46, Issue:7 | Design, synthesis and antifungal activities of novel 1,2,4-triazole derivatives. |
| AID575749 | Antimicrobial activity against sterol 14-alpha demethylase isoenzyme A-deficient Aspergillus fumigatus CEA10 | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10 | Expression, purification, and characterization of Aspergillus fumigatus sterol 14-alpha demethylase (CYP51) isoenzymes A and B. |
| AID565553 | Antifungal activity against Rhizopus microsporus UTHSC 03-1802 by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Correlation of in vitro activity, serum levels, and in vivo efficacy of posaconazole against Rhizopus microsporus in a murine disseminated infection. |
| AID1270909 | Antifungal activity against Candida albicans ATCC 24433 assessed as growth inhibition after 24 hrs by broth microdilution assay | 2015 | Journal of natural products, Nov-25, Volume: 78, Issue:11 | Synergistic Antifungal Meroterpenes and Dioxolanone Derivatives from the Endophytic Fungus Guignardia sp. |
| AID1601665 | Antifungal activity against planktonic form of Candida albicans PMC 1042 by broth microdilution method | |||
| AID525592 | Antibacterial activity against Fluconazole resistant Candida albicans DSY3083 containing tac1delta/delta genotype by EUCAST standards based broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Genetic dissection of azole resistance mechanisms in Candida albicans and their validation in a mouse model of disseminated infection. |
| AID285868 | Antimicrobial susceptibility of Pichia anomala from nosocomial fungemia patient assessed as percent susceptible isolates at 0.5 ug/ml by EUCAST method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Antifungal drug susceptibility profile of Pichia anomala isolates from patients presenting with nosocomial fungemia. |
| AID1157160 | Antifungal activity against Candida parapsilosis ATCC 22019 after 48 hrs by CLSI broth microdilution method | 2014 | European journal of medicinal chemistry, Aug-18, Volume: 83 | Synthesis, biological evaluation and structure-activity correlation study of a series of imidazol-based compounds as Candida albicans inhibitors. |
| AID1877280 | Antifungal activity against Candida albicans CPCC400616 assessed as fungal growth inhibition by NCCLS protocol based method | 2022 | European journal of medicinal chemistry, Jan-05, Volume: 227 | Broadening antifungal spectrum and improving metabolic stablity based on a scaffold strategy: Design, synthesis, and evaluation of novel 4-phenyl-4,5-dihydrooxazole derivatives as potent fungistatic and fungicidal reagents. |
| AID1369464 | Fungicidal activity against Candida albicans 14936 after 96 hrs | 2018 | Journal of medicinal chemistry, 05-10, Volume: 61, Issue:9 | Combating Drug-Resistant Fungi with Novel Imperfectly Amphipathic Palindromic Peptides. |
| AID333840 | Antifungal activity against azole-resistant Candida glabrata by broth microdilution assay | 2005 | Journal of natural products, Dec, Volume: 68, Issue:12 | Antifungal flavonoids from Hildegardia barteri. |
| AID1176264 | Antifungal activity against Mucor racemosus after 2 to 7 days by serial plate dilution method | 2015 | Bioorganic & medicinal chemistry letters, Jan-15, Volume: 25, Issue:2 | Ionic liquid catalyzed synthesis of 2-(indole-3-yl)-thiochroman-4-ones and their novel antifungal activities. |
| AID1546161 | Antifungal activity against Aspergillus niger | 2019 | European journal of medicinal chemistry, Dec-15, Volume: 184 | Current scenario of tetrazole hybrids for antibacterial activity. |
| AID1872517 | In vivo antifungal activity against Candida albicans infected in CDF1 mouse treated po 4 hrs after injection twice daily for 2 days measured on day 10 | 2022 | European journal of medicinal chemistry, Mar-05, Volume: 231 | Synthetic approaches and structural diversity of triazolylbutanols derived from voriconazole in the antifungal drug development. |
| AID567857 | Antifungal activity against Aspergillus niger MTCC 281 after 72 hrs | 2011 | European journal of medicinal chemistry, Feb, Volume: 46, Issue:2 | Synthesis, antidepressant and antifungal evaluation of novel 2-chloro-8-methylquinoline amine derivatives. |
| AID1279027 | Antifungal activity against Candida glabrata 20/I after 24 hrs by microbroth dilution method | 2016 | Bioorganic & medicinal chemistry, Mar-15, Volume: 24, Issue:6 | Salicylanilide N-monosubstituted carbamates: Synthesis and in vitro antimicrobial activity. |
| AID1465975 | Antifungal activity against Candida albicans ATCC 64124 after 44 hrs by broth dilution assay | 2017 | Bioorganic & medicinal chemistry, 06-01, Volume: 25, Issue:11 | Investigation of aryl isonitrile compounds with potent, broad-spectrum antifungal activity. |
| AID1609936 | Inhibition of Candida albicans CYP51 assessed as increase in eburicol level at 0.25 ug/ml incubated for 18 hrs by GC/MS analysis relative to control | |||
| AID678712 | Inhibition of human CYP1A2 assessed as ratio of IC50 in absence of NADPH to IC50 for presence of NADPH using ethoxyresorufin as substrate after 30 mins | 2012 | Chemical research in toxicology, Oct-15, Volume: 25, Issue:10 | Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds. |
| AID1242642 | Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC 700699 after 16 hrs by microtiter broth dilution method | 2015 | ACS medicinal chemistry letters, Jul-09, Volume: 6, Issue:7 | Novel Chalcone-Thiazole Hybrids as Potent Inhibitors of Drug Resistant Staphylococcus aureus. |
| AID244786 | Antifungal activity to cause 99% reduction of surviving cells | 2004 | Journal of medicinal chemistry, Jul-29, Volume: 47, Issue:16 | Imidazole analogues of fluoxetine, a novel class of anti-Candida agents. |
| AID1419573 | Selectivity index, ratio of EC50 for toxicity in human A549 cells to MIC50 for antifungal activity against Aspergillus terreus ATCC MYA-3633 | 2017 | European journal of medicinal chemistry, Jun-16, Volume: 133 | Novel alkylated azoles as potent antifungals. |
| AID329032 | Antifungal activity against Candida albicans ATCC 90028 after 24 hrs by serial agar dilution method | 2008 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 18, Issue:8 | Synthesis and antimicrobial properties of monensin A esters. |
| AID1762150 | Antifungal activity against Candida albicans ATCC 24433 assessed as reduction in fungal growth incubated for 24 hrs by CLSI based serial microbroth dilution method | 2021 | Bioorganic & medicinal chemistry letters, 05-15, Volume: 40 | Synthesis and antifungal activity of new hybrids thiazolo[4,5-d]pyrimidines with (1H-1,2,4)triazole. |
| AID1886029 | Synergistic antifungal activity against Cryptococcus gattii E566 assessed as fractional inhibitory concentration index incubated for 72 hrs in presence of P163-0892 by broth microdilution method | |||
| AID1738735 | Inhibition of CYP51 in azole-resistant Candida albicans ATCC SC531 assessed as Obtusifoliol level at 0.5 ug/ml incubated for 16 hrs by LC-MS analysis relative to control | 2020 | European journal of medicinal chemistry, Jul-15, Volume: 198 | Design, synthesis, and biological evaluation of novel miconazole analogues containing selenium as potent antifungal agents. |
| AID561423 | Antifungal activity against Candida lusitaniae CL38-5 by microdilution method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Nonsense and missense mutations in FCY2 and FCY1 genes are responsible for flucytosine resistance and flucytosine-fluconazole cross-resistance in clinical isolates of Candida lusitaniae. |
| AID1413578 | Antifungal activity against Candida tropicalis ATCC 1369 by broth microdilution method | |||
| AID1592326 | Antifungal activity against Aspergillus niger NCIM1196 by standard agar method | 2019 | European journal of medicinal chemistry, Apr-01, Volume: 167 | Efficient click chemistry towards novel 1H-1,2,3-triazole-tethered 4H-chromene-d-glucose conjugates: Design, synthesis and evaluation of in vitro antibacterial, MRSA and antifungal activities. |
| AID1595125 | Antifungal activity against Aspergillus niger assessed as reduction in fungal cell growth incubated for 48 hrs by broth microdilution method | 2019 | European journal of medicinal chemistry, May-15, Volume: 170 | Tetrazole hybrids and their antifungal activities. |
| AID521790 | Fungistatic activity against Candida glabrata isolate 4198 assessed as 99.9% reduction of initial fungal load at 0.5 times MIC after 48 hrs using colony count method by time-kill method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Posaconazole against Candida glabrata isolates with various susceptibilities to fluconazole. |
| AID1061741 | Antimicrobial activity against Candida parapsilosis by broth microdilution method | 2014 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 24, Issue:1 | Synthesis and evaluation of novel azoles as potent antifungal agents. |
| AID1759450 | Cytotoxicity against human HEK293 cells assessed as cell survival at 1 times MIC incubated for 24 hrs by MTT assay | 2021 | Bioorganic & medicinal chemistry letters, 06-01, Volume: 41 | Inhibitory effects and mechanism of antifungal action of the natural cyclic depsipeptide, aureobasidin A against Cryptococcus neoformans. |
| AID1864911 | Antifungal actvity against Candida albicans ATCC SC5314 infected in mouse assessed as reduction in infection at 10 ug per 20 g, ip administered on day 2, 4, 6, 8, 10 and 12 and measured on day 14 in presence of naproxen | |||
| AID453726 | Antifungal activity against Candida 6 after 72 to 96 hrs by twofold serial dilution method | 2010 | Bioorganic & medicinal chemistry letters, Jan-15, Volume: 20, Issue:2 | Synthesis, spectral analysis and in vitro microbiological evaluation of 3-(3-alkyl-2,6-diarylpiperin-4-ylidene)-2-thioxoimidazolidin-4-ones as a new class of antibacterial and antifungal agents. |
| AID566724 | Antifungal activity against Candida albicans after 24 hrs by MTT assay | 2011 | European journal of medicinal chemistry, Jan, Volume: 46, Issue:1 | Synthesis and biological evaluation of novel 2,4-disubstituted-1,3-thiazoles as anti-Candida spp. agents. |
| AID49822 | Fungicidal versus fungistatic activity of bifunctional sphingolipids against Candida glabrata at a concentration of 5 ug/mL before dilution replating; no growth in media | 2002 | Bioorganic & medicinal chemistry letters, Aug-19, Volume: 12, Issue:16 | Antifungal activity of bifunctional sphingolipids. Intramolecular synergism within long-chain alpha,omega-bis-aminoalcohols. |
| AID522123 | Fungistatic activity against calcineurin deltacnb1 mutant containing Candida glabrata TG163 complemented with CNB1 gene assessed as reduction in bacterial cell viability by time kill study | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Roles of calcineurin and Crz1 in antifungal susceptibility and virulence of Candida glabrata. |
| AID1651341 | Antifungal activity against Candida albicans SC5314 by NCCLS protocol based broth microdilution assay | 2020 | Bioorganic & medicinal chemistry letters, 02-15, Volume: 30, Issue:4 | Design, synthesis, and structure-activity relationship studies of novel triazole agents with strong antifungal activity against Aspergillus fumigatus. |
| AID493519 | Antifungal activity against Trichosporon asahii 1188 after 24 hrs by broth microdilution assay | 2010 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 20, Issue:15 | N-Benzylsalicylthioamides as novel compounds with promising antimycotic activity. |
| AID1885992 | Antifungal activity against Cryptococcus neoformans clinical isolate HN15 assessed as fungal growth inhibition incubated for 72 hrs in presence of P163-0892 by broth microdilution method | |||
| AID307627 | Antifungal activity against Candida albicans CA980001 by alamar blue assay | 2007 | Bioorganic & medicinal chemistry letters, Jul-01, Volume: 17, Issue:13 | Synthesis and antifungal activities of new fluconazole analogues with azaheterocycle moiety. |
| AID574614 | Antifungal activity against Absidia corymbifera 272 after 48 hrs by broth microdilution method | 2011 | Bioorganic & medicinal chemistry, Feb-15, Volume: 19, Issue:4 | Synthesis and antimycobacterial properties of N-substituted 6-amino-5-cyanopyrazine-2-carboxamides. |
| AID293782 | Antimicrobial activity against Candida glabrata ATCC 10231 by broth microdilution method | 2007 | Bioorganic & medicinal chemistry, Mar-01, Volume: 15, Issue:5 | Synthesis, antimicrobial activity, and QSAR studies of furan-3-carboxamides. |
| AID582786 | Antifungal activity against Candida albicans isolate 177 assessed as lanosterol/obtusifoliol content in total sterol composition at 0.5 times MIC by GC-MS analysis | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | Identification and characterization of four azole-resistant erg3 mutants of Candida albicans. |
| AID457989 | Antifungal activity against Candida glabrata 20/I after 24 hrs by microdilution method | 2010 | Bioorganic & medicinal chemistry, Mar-01, Volume: 18, Issue:5 | Antifungal 3,5-disubstituted furanones: From 5-acyloxymethyl to 5-alkylidene derivatives. |
| AID623050 | Antifungal activity against Trichosporon asahii 1188 after 24 hrs by microdilution method | 2011 | Bioorganic & medicinal chemistry letters, Oct-15, Volume: 21, Issue:20 | Synthesis and biological activity of desmethoxy analogues of coruscanone A. |
| AID670446 | Antifungal activity against Trichophyton rubrum incubated at 35 degC for 72 hrs by NCCLS based microbroth dilution method | 2012 | Bioorganic & medicinal chemistry letters, Jul-15, Volume: 22, Issue:14 | Synthesis and biological evaluation of vinyl ether-containing azole derivatives as inhibitors of Trichophyton rubrum. |
| AID555047 | Antimicrobial activity against Candida glabrata SSI-M68190-2007 by EUCAST method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Breakpoints for susceptibility testing should not divide wild-type distributions of important target species. |
| AID1743166 | Antifungal activity against Trichophyton rubrum | 2020 | European journal of medicinal chemistry, Dec-15, Volume: 208 | Multiple biological active 4-aminopyrazoles containing trifluoromethyl and their 4-nitroso-precursors: Synthesis and evaluation. |
| AID1872522 | Antifungal activity against Aspergillus flavus SANK 18497 by 96-well microplate method | 2022 | European journal of medicinal chemistry, Mar-05, Volume: 231 | Synthetic approaches and structural diversity of triazolylbutanols derived from voriconazole in the antifungal drug development. |
| AID446452 | Antifungal activity against fluconazole-resistant Candida albicans CA284 | 2009 | Bioorganic & medicinal chemistry letters, Oct-15, Volume: 19, Issue:20 | Design of new antifungal agents: synthesis and evaluation of 1-[(1H-indol-5-ylmethyl)amino]-2-phenyl-3-(1H-1,2,4-triazol-1-yl)propan-2-ols. |
| AID1254327 | Antifungal activity against Absidia corymbifera 272 after 48 hrs by microdilution broth method | 2015 | Bioorganic & medicinal chemistry, Nov-15, Volume: 23, Issue:22 | Novel derivatives of nitro-substituted salicylic acids: Synthesis, antimicrobial activity and cytotoxicity. |
| AID1329223 | Inhibition of CDR1/CDR2 in Candida albicans clinical isolate 142 assessed as potentiation of fluconazole-induced antifungal activity by measuring fluconazole MIC80 up to 8 ug/ml after 24 hrs by XTT based broth microdilution assay (Rvb = >128 ug/ml) | 2016 | Journal of natural products, 09-23, Volume: 79, Issue:9 | Heptaketides from an Endolichenic Fungus Biatriospora sp. and Their Antifungal Activity. |
| AID531249 | Antifungal activity against Candida tropicalis assessed as resistant isolates after 48 hrs by CLSI method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | In vitro susceptibilities of invasive isolates of Candida species: rapid increase in rates of fluconazole susceptible-dose dependent Candida glabrata isolates. |
| AID634087 | Antifungal activity against Candida albicans assessed as morphogenetic transformation after 3 hrs by phase-contrast microscopy | 2012 | European journal of medicinal chemistry, Jan, Volume: 47, Issue:1 | Antifungal activities of novel non-azole molecules against S. cerevisiae and C. albicans. |
| AID521525 | Antifungal activity against Candida albicans ATCC MYA-573 after 47 hrs by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | In vitro and in vivo antifungal activities of T-2307, a novel arylamidine. |
| AID1885966 | Antifungal activity against Cryptococcus neoformans clinical isolate HN2 assessed as fungal growth inhibition incubated for 72 hrs by broth microdilution method | |||
| AID1392822 | Inhibition of Cyp51 in Candida albicans ATCC SC5314 assessed as lanosterol content at 0.5 ug/ml after 16 hrs by GC-MS analysis relative to control | 2018 | Bioorganic & medicinal chemistry, 07-23, Volume: 26, Issue:12 | Design, synthesis and evaluation of benzoheterocycle analogues as potent antifungal agents targeting CYP51. |
| AID372235 | Effect on CDR4 RNA level in Candida albicans CHK21 at MIC after 120 mins by RT-PCR | 2007 | Antimicrobial agents and chemotherapy, Oct, Volume: 51, Issue:10 | The Ssk1p response regulator and Chk1p histidine kinase mutants of Candida albicans are hypersensitive to fluconazole and voriconazole. |
| AID565399 | Antifungal activity against Rhizopus microsporus IHEM 18821 by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Correlation of in vitro activity, serum levels, and in vivo efficacy of posaconazole against Rhizopus microsporus in a murine disseminated infection. |
| AID1071689 | Cytotoxicity against human PBMC assessed as cell viability after 72 hrs by MTT assay | 2014 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 24, Issue:5 | Antifungal ether diglycosides from Matayba guianensis Aublet. |
| AID1904244 | Anti-cryptococcal activity against Cryptococcus neoformans H99 assessed as inhibition of fungal growth at 1 to 8 ug/ml incubated upto 72 hrs by time-growth curve assay | 2022 | Journal of medicinal chemistry, 05-12, Volume: 65, Issue:9 | Discovery of Novel Sertraline Derivatives as Potent Anti- |
| AID581862 | Antifungal activity against Candida krusei isolated from neutropenic subjects with AML or MDS receiving fluconazole assessed as maximum MIC by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Impact of antifungal prophylaxis on colonization and azole susceptibility of Candida species. |
| AID1885991 | Antifungal activity against Cryptococcus neoformans clinical isolate HN2-40 assessed as fungal growth inhibition incubated for 72 hrs in presence of P163-0892 by broth microdilution method | |||
| AID509286 | Permeability across BBMEC cocultured with rat C6 cell BBB model after 24 hrs in presence of 0.1 ug/ml cyclosporin | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Effects of immunomodulatory and organism-associated molecules on the permeability of an in vitro blood-brain barrier model to amphotericin B and fluconazole. |
| AID405056 | Antifungal activity against Sporothrix schenckii PJRC002 isolate from cutaneous-lymphatic sporotrichosis patient after 72 hrs by ATB Fungus 2 method | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | In vitro susceptibility of Sporothrix schenckii to six antifungal agents determined using three different methods. |
| AID521796 | Fungistatic activity against Candida glabrata isolate 4205 assessed as 99.9% reduction of initial fungal load at 8 times MIC after 48 hrs using colony count method by time-kill method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Posaconazole against Candida glabrata isolates with various susceptibilities to fluconazole. |
| AID1242647 | Antifungal activity against Cryptococcus neoformans after 16 hrs by microtiter broth dilution method | 2015 | ACS medicinal chemistry letters, Jul-09, Volume: 6, Issue:7 | Novel Chalcone-Thiazole Hybrids as Potent Inhibitors of Drug Resistant Staphylococcus aureus. |
| AID1494174 | Antifungal activity against Candida albicans ATCC 64124 measured after 48 hrs by CLSI M27-A3 protocol based method | 2018 | Bioorganic & medicinal chemistry, 02-01, Volume: 26, Issue:3 | Novel fluconazole derivatives with promising antifungal activity. |
| AID549049 | Antifungal activity against Candida albicans CA132 after 48 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | In vitro activities of retigeric acid B alone and in combination with azole antifungal agents against Candida albicans. |
| AID544875 | Antimicrobial activity against Candida dubliniensis harboring MRR1 CD57 mutant gene by microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | Gain-of-function mutations in the transcription factor MRR1 are responsible for overexpression of the MDR1 efflux pump in fluconazole-resistant Candida dubliniensis strains. |
| AID1360752 | Antifungal activity against Aspergillus niger MTCC 8189 after 120 hrs by serial dilution method | 2018 | European journal of medicinal chemistry, Jul-15, Volume: 155 | Synthesis, crystal structure and antimicrobial potential of some fluorinated chalcone-1,2,3-triazole conjugates. |
| AID753237 | Antifungal activity against Aspergillus flavus after 24 hrs by two-fold serial dilution method | 2013 | European journal of medicinal chemistry, Jun, Volume: 64 | Design, synthesis and antimicrobial evaluation of novel benzimidazole type of Fluconazole analogues and their synergistic effects with Chloromycin, Norfloxacin and Fluconazole. |
| AID554996 | Antifungal activity against Candida tropicalis assessed as percent susceptible isolates at 25 ug/disc by CLSI M44-A disk diffusion method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | In vitro activities of fluconazole and voriconazole against clinical isolates of Candida spp. determined by disk diffusion testing in Turin, Italy. |
| AID1595068 | Antifungal activity against Aspergillus fumigatus assessed as inhibition zone at 20 ug/ml by disk diffusion method | 2019 | European journal of medicinal chemistry, May-15, Volume: 170 | Tetrazole hybrids and their antifungal activities. |
| AID518416 | Antimicrobial activity against Cryptococcus gattii serotype B isolate RAM002 assessed as heteroresistant isolates at 2 ug/ml | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Heteroresistance of Cryptococcus gattii to fluconazole. |
| AID532954 | Antifungal activity against Candida albicans isolate V4 with CAI genotype by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | Correlation between azole susceptibilities, genotypes, and ERG11 mutations in Candida albicans isolates associated with vulvovaginal candidiasis in China. |
| AID1585625 | Antifungal activity against Candida albicans SC5314 cultured in YNB media after 24 hrs by broth microdilution method | 2019 | European journal of medicinal chemistry, Jan-15, Volume: 162 | Chemical preparation, biological evaluation and 3D-QSAR of ethoxysulfuron derivatives as novel antifungal agents targeting acetohydroxyacid synthase. |
| AID1707485 | Antifungal activity against Candida albicans 9884 incubated for 48 hrs by microdilution assay | 2021 | Journal of medicinal chemistry, 01-28, Volume: 64, Issue:2 | Novel Carboline Fungal Histone Deacetylase (HDAC) Inhibitors for Combinational Treatment of Azole-Resistant Candidiasis. |
| AID1155875 | Antifungal activity against Microsporum gypseum assessed as growth inhibition by serial dilution method | 2014 | European journal of medicinal chemistry, Jul-23, Volume: 82 | Design, synthesis and antifungal activity of novel triazole derivatives containing substituted 1,2,3-triazole-piperdine side chains. |
| AID54876 | Evaluation of In vitro antifungal activity against Cryptococcus neoformans 74 by broth macro dilution method | 1995 | Journal of medicinal chemistry, Sep-29, Volume: 38, Issue:20 | Synthesis and antifungal activity of new azole derivatives containing an N-acylmorpholine ring. |
| AID1783769 | Antifungal activity against Candida tropicalis GIM2.183 assessed as inhibition of fungal growth by NCCLS protocol based method | 2021 | European journal of medicinal chemistry, Nov-15, Volume: 224 | Improving the metabolic stability of antifungal compounds based on a scaffold hopping strategy: Design, synthesis, and structure-activity relationship studies of dihydrooxazole derivatives. |
| AID602926 | Antifungal activity against Candida albicans SC5314 after 24 hrs by micro-broth dilution method | 2011 | European journal of medicinal chemistry, Jul, Volume: 46, Issue:7 | Design, synthesis and antifungal evaluation of 1-(2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propyl)-1H-1,2,4-triazol-5(4H)-one. |
| AID307403 | Antifungal activity against Aspergillus niger ATCC 9042 by broth microdilution assay | 2007 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 17, Issue:12 | Discovery of novel indazole-linked triazoles as antifungal agents. |
| AID737317 | Antimicrobial activity against Aspergillus flavus MTCC 1973 at 500 ug/ml after 72 hrs by cup plate method | 2013 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 23, Issue:7 | Synthesis of novel 2-amino-4-(5'-substituted 2'-phenyl-1H-indol-3'-yl)-6-aryl-4H-pyran-3-carbonitrile derivatives as antimicrobial and antioxidant agents. |
| AID1905259 | Antifungal activity against fluconazole-resistant Candida albicans 904 assessed as inhibition of fungal growth by checker board microdilution assay | 2022 | Journal of medicinal chemistry, 04-14, Volume: 65, Issue:7 | Species-Selective Targeting of Fungal Hsp90: Design, Synthesis, and Evaluation of Novel 4,5-Diarylisoxazole Derivatives for the Combination Treatment of Azole-Resistant Candidiasis. |
| AID547610 | Antifungal activity against Candida glabrata isolate Cg1S | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | Microarray and molecular analyses of the azole resistance mechanism in Candida glabrata oropharyngeal isolates. |
| AID1491249 | Inhibition of CYP51 in Candida albicans ATCC SC5314 assessed as increase in lanosterol content by GS-MS analysis | 2017 | European journal of medicinal chemistry, Sep-08, Volume: 137 | Design, synthesis and evaluation of aromatic heterocyclic derivatives as potent antifungal agents. |
| AID1598045 | Antifungal activity against Trichophyton rubrum after 24 hrs | 2019 | European journal of medicinal chemistry, May-15, Volume: 170 | Current advances of triazole alcohols derived from fluconazole: Design, in vitro and in silico studies. |
| AID118058 | In vivo evaluation of % survival rate after peroral administration on 5th day at dose 10 mg/kg | 1995 | Journal of medicinal chemistry, Sep-29, Volume: 38, Issue:20 | Synthesis and antifungal activity of new azole derivatives containing an N-acylmorpholine ring. |
| AID675306 | Antibacterial activity against Shigella dysenteriae by two fold broth dilution method | 2012 | Bioorganic & medicinal chemistry letters, Sep-01, Volume: 22, Issue:17 | Design, synthesis and evaluation of clinafloxacin triazole hybrids as a new type of antibacterial and antifungal agents. |
| AID1600169 | Antifungal activity against Aspergillus niger NCIM 504 assessed as zone of inhibition at 80 ug/well incubated for 48 to 72 hrs by by agar well diffusion method | 2019 | European journal of medicinal chemistry, Oct-01, Volume: 179 | Synthesis of new thiazolyl-pyrazolyl-1,2,3-triazole derivatives as potential antimicrobial agents. |
| AID602933 | Antifungal activity against Aspergillus fumigatus by broth microdilution method | 2011 | European journal of medicinal chemistry, Jul, Volume: 46, Issue:7 | Design, synthesis and antifungal evaluation of 1-(2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propyl)-1H-1,2,4-triazol-5(4H)-one. |
| AID1762171 | Antifungal activity against Trichophyton rubrum 2002 assessed as reduction in fungal growth incubated for 48 hrs by CLSI based serial microbroth dilution method | 2021 | Bioorganic & medicinal chemistry letters, 05-15, Volume: 40 | Synthesis and antifungal activity of new hybrids thiazolo[4,5-d]pyrimidines with (1H-1,2,4)triazole. |
| AID42883 | Inhibition of Candida lusitaniae 2446/I growth for 48 hours in vitro. | 2001 | Journal of medicinal chemistry, Aug-16, Volume: 44, Issue:17 | 3-Phenyl-5-acyloxymethyl-2H,5H-furan-2-ones: synthesis and biological activity of a novel group of potential antifungal drugs. |
| AID716245 | Antimicrobial activity against Candida mycoderma by microbroth dilution method | 2012 | European journal of medicinal chemistry, Sep, Volume: 55 | Synthesis and biological evaluation of novel benzimidazole derivatives and their binding behavior with bovine serum albumin. |
| AID419077 | Antifungal activity against Aspergillus flavus SANK 18497 | 2009 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 19, Issue:7 | Amide analogs of antifungal dioxane-triazole derivatives: synthesis and in vitro activities. |
| AID1610310 | Antifungal activity against fluconazole-resistant Candida albicans isolate 103 incubated for 24 hrs by CLSI protocol based microbroth dilution method | 2019 | Bioorganic & medicinal chemistry letters, 12-01, Volume: 29, Issue:23 | Design, synthesis and biological evaluation of novel semicarbazone-selenochroman-4-ones hybrids as potent antifungal agents. |
| AID576544 | Antimicrobial activity against Candida albicans SC5314 assessed as reduction of biofilm metabolic activity in in vitro catheter-associated rat model at 64 ug/ml by XTT assay | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10 | In vivo efficacy of anidulafungin against mature Candida albicans biofilms in a novel rat model of catheter-associated Candidiasis. |
| AID717902 | Antimicrobial activity against Candida tropicalis 156 after 24 hrs by broth microdilution test | 2012 | Bioorganic & medicinal chemistry, Dec-15, Volume: 20, Issue:24 | Contribution to investigation of antimicrobial activity of styrylquinolines. |
| AID670400 | Antifungal activity against Candida glabrata MTCC 3019 by well diffusion method | 2012 | Bioorganic & medicinal chemistry letters, Jul-15, Volume: 22, Issue:14 | Synthesis, biological evaluation of 5-carbomethoxymethyl-7-hydroxy-2-pentylchromone, 5-carboethoxymethyl-4',7-dihydroxyflavone and their analogues. |
| AID1474172 | Antifungal activity against Candida tropicalis cgmcc 2.3739 by broth microdilution assay | 2016 | European journal of medicinal chemistry, Nov-10, Volume: 123 | Design, synthesis, and structure-activity relationship studies of benzothiazole derivatives as antifungal agents. |
| AID531537 | Antifungal activity against Candida glabrata clinical isolate obtained from cervicovaginal candidiasis patient assessed as susceptible isolates by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Antifungal resistance of Candida glabrata vaginal isolates and development of a quantitative reverse transcription-PCR-based azole susceptibility assay. |
| AID531252 | Antifungal activity against Candida krusei assessed as resistant isolates after 48 hrs by CLSI method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | In vitro susceptibilities of invasive isolates of Candida species: rapid increase in rates of fluconazole susceptible-dose dependent Candida glabrata isolates. |
| AID750764 | Antifungal activity against Aspergillus flavus MTCC 1021 after 48 hrs | 2013 | European journal of medicinal chemistry, Jun, Volume: 64 | Biological activity, design, synthesis and structure activity relationship of some novel derivatives of curcumin containing sulfonamides. |
| AID619185 | Antifungal activity against Candida albicans AN 3156 by broth dilution method | 2011 | Journal of medicinal chemistry, Oct-13, Volume: 54, Issue:19 | High-throughput-screening-based identification and structure-activity relationship characterization defined (S)-2-(1-aminoisobutyl)-1-(3-chlorobenzyl)benzimidazole as a highly antimycotic agent nontoxic to cell lines. |
| AID518877 | Antimicrobial activity against Cryptococcus gattii serotype C isolate H0058-1-818 assessed as heteroresistant isolates at 16 ug/ml | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Heteroresistance of Cryptococcus gattii to fluconazole. |
| AID613763 | Antifungal activity against Fusarium proliferatum ATCC 10052 at 128 ug/ml by broth dilution method | 2011 | Bioorganic & medicinal chemistry letters, Aug-15, Volume: 21, Issue:16 | Novel hybrids of fluconazole and furanones: design, synthesis and antifungal activity. |
| AID1472821 | Antifungal activity against Candida krusei ATCC 6258 after 48 hrs by broth dilution method | 2018 | Journal of medicinal chemistry, 01-11, Volume: 61, Issue:1 | Alkylated Piperazines and Piperazine-Azole Hybrids as Antifungal Agents. |
| AID1759434 | Antifungal activity against Cryptococcus neoformans PFCC 93-589 after 2 days in presence of sorbitol by microdilution assay | 2021 | Bioorganic & medicinal chemistry letters, 06-01, Volume: 41 | Inhibitory effects and mechanism of antifungal action of the natural cyclic depsipeptide, aureobasidin A against Cryptococcus neoformans. |
| AID44970 | Antifungal activity against Candida albicans NCPF 3179 strain; na = not active | 2004 | Journal of medicinal chemistry, Apr-08, Volume: 47, Issue:8 | Distamycin analogues with enhanced lipophilicity: synthesis and antimicrobial activity. |
| AID424626 | Antimicrobial activity against azole-resistant Candida albicans isolate CA135 after 48 hrs by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | In vitro interactions between tacrolimus and azoles against Candida albicans determined by different methods. |
| AID424637 | Antimicrobial activity against azole-resistant Candida albicans isolate CA137 cotreated with calcineurin signaling inhibitor Tacrolimus after 48 hrs by microdilution checkerboard technique | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | In vitro interactions between tacrolimus and azoles against Candida albicans determined by different methods. |
| AID1651346 | Antifungal activity against Candida glabrata 537 by NCCLS protocol based broth microdilution assay | 2020 | Bioorganic & medicinal chemistry letters, 02-15, Volume: 30, Issue:4 | Design, synthesis, and structure-activity relationship studies of novel triazole agents with strong antifungal activity against Aspergillus fumigatus. |
| AID584588 | Antifungal activity against -2 days cultured Candida glabrata isolated from HSCT recipient with acute or chronic GVHD mouth receiving antifungal therapy for 168 days after 113 days of prophylaxis by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Impact of antifungal prophylaxis on colonization and azole susceptibility of Candida species. |
| AID518153 | Antimicrobial activity against Cryptococcus gattii serotype C isolate NIH178 assessed as concentration required for heteroresistance | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Heteroresistance of Cryptococcus gattii to fluconazole. |
| AID1491271 | Inhibition of CYP51 in Candida albicans ATCC SC5314 assessed as 4,4-dimethyl zymosterol content at 8 ug/ml by GS-MS analysis relative to total sterols | 2017 | European journal of medicinal chemistry, Sep-08, Volume: 137 | Design, synthesis and evaluation of aromatic heterocyclic derivatives as potent antifungal agents. |
| AID542092 | Antifungal activity against Candida kefyr ATCC 46764 after 24 hrs by microdilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Discovery of a small-molecule inhibitor of {beta}-1,6-glucan synthesis. |
| AID1221964 | Transporter substrate index ratio of permeability from basolateral to apical side in human Caco2 cells at 10 uM up to 120 mins by HPLC-MC analysis in presence of 1 uM of P-gp inhibitor LY335979 | 2011 | Drug metabolism and disposition: the biological fate of chemicals, Feb, Volume: 39, Issue:2 | Attenuation of intestinal absorption by major efflux transporters: quantitative tools and strategies using a Caco-2 model. |
| AID314995 | Antifungal activity against Candida albicans CA98001 | 2008 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 18, Issue:6 | Design, synthesis, and evaluation of 1-(N-benzylamino)-2-phenyl-3-(1H-1,2,4-triazol-1-yl)propan-2-ols as antifungal agents. |
| AID497800 | Antifungal activity against Candida glabrata assessed as fungicidal activity by broth microdilution assay | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Assessment of the in vitro kinetic activity of caspofungin against Candida glabrata. |
| AID1890297 | Antifungal activity against Mucor circinelloides R7B wild type strain assessed as morphological differentiation into hyphae at 25 ug/ml by microscopic analysis | 2022 | Bioorganic & medicinal chemistry letters, 05-01, Volume: 63 | Novel 2-aryl-4-aryloxyquinoline-based fungistatics for Mucor circinelloides. Biological evaluation of activity, QSAR and docking study. |
| AID1510726 | Antibacterial activity against Escherichia coli | 2019 | European journal of medicinal chemistry, Oct-01, Volume: 179 | Nitroimidazole-containing compounds and their antibacterial and antitubercular activities. |
| AID1864918 | Toxicity in mouse infected with Candida albicans assessed as kidney injury at 10 ug per 20 g, ip administered on day 2, 4, 6, 8, 10 and 12 and measured on day 14 by H and E staining based assay | |||
| AID1877865 | Effect on Candida albicans efflux pump assessed as intracellular Rh6G level at 1 ug/ml by fluorescence analysis | 2022 | Bioorganic & medicinal chemistry letters, 02-15, Volume: 58 | Synthesis and antifungal evaluation of phenol-derived bis(indolyl)methanes combined with FLC against Candida albicans. |
| AID717901 | Antimicrobial activity against Candida krusei ATCC 6258 after 24 hrs by broth microdilution test | 2012 | Bioorganic & medicinal chemistry, Dec-15, Volume: 20, Issue:24 | Contribution to investigation of antimicrobial activity of styrylquinolines. |
| AID1335847 | Antifungal activity against Beer yeast after 24 hrs by two fold serial dilution method | 2016 | European journal of medicinal chemistry, Nov-29, Volume: 124 | Multi-targeting exploration of new 2-aminothiazolyl quinolones: Synthesis, antimicrobial evaluation, interaction with DNA, combination with topoisomerase IV and penetrability into cells. |
| AID47256 | Compound was tested in vitro for antifungal activity against Candida albicans (CY3003) | 1998 | Bioorganic & medicinal chemistry letters, Jul-21, Volume: 8, Issue:14 | Modeling, synthesis and biological activity of novel antifungal agents (1). |
| AID465558 | Antifungal activity against Cryptococcus neoformans by NCCLS broth microdilution method | 2010 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 20, Issue:5 | Stereospecific synthesis of oximes and oxime ethers of 3-azabicycles: A SAR study towards antimicrobial agents. |
| AID47095 | In vivo effective dose for antifungal activity on sc administration in female mice infected with 2.5*10e6 cells/mL of Candida albicans at day 10 | 2001 | Bioorganic & medicinal chemistry letters, Feb-12, Volume: 11, Issue:3 | FR131535, a novel water-soluble echinocandin-like lipopeptide: synthesis and biological properties. |
| AID490938 | Antifungal activity against Candida albicans NCIM 3100 after 72 hrs by disc diffusion method | 2010 | European journal of medicinal chemistry, Jul, Volume: 45, Issue:7 | Synthesis and biological evaluation of a novel series of 2,2-bisaminomethylated aurone analogues as anti-inflammatory and antimicrobial agents. |
| AID1252948 | Antifungal activity against Candida albicans SC5314 assessed as inhibition of biofilm formation by XTT assay | 2015 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 25, Issue:22 | Sesquiterpenes from Carpesium macrocephalum inhibit Candida albicans biofilm formation and dimorphism. |
| AID1592327 | Antifungal activity against Candida albicans NCIM3471 by standard agar method | 2019 | European journal of medicinal chemistry, Apr-01, Volume: 167 | Efficient click chemistry towards novel 1H-1,2,3-triazole-tethered 4H-chromene-d-glucose conjugates: Design, synthesis and evaluation of in vitro antibacterial, MRSA and antifungal activities. |
| AID214268 | In vitro evaluation of minimum inhibitory concentration against Trichophyton mentagrophytes 23 | 1995 | Journal of medicinal chemistry, Sep-29, Volume: 38, Issue:20 | Synthesis and antifungal activity of new azole derivatives containing an N-acylmorpholine ring. |
| AID287830 | Antifungal activity against Aspergillus fumigatus 231 after 48 hrs | 2007 | Bioorganic & medicinal chemistry, Apr-15, Volume: 15, Issue:8 | Hybrid molecules of estrone: new compounds with potential antibacterial, antifungal, and antiproliferative activities. |
| AID279111 | Mortality rate stratified by 48 hrs MIC in resistant Candida species infected patient | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Association of fluconazole area under the concentration-time curve/MIC and dose/MIC ratios with mortality in nonneutropenic patients with candidemia. |
| AID323075 | Antifungal activity against Cryptococcus neoformans IM 961951 by micro-broth dilution method | 2008 | Bioorganic & medicinal chemistry, Jan-15, Volume: 16, Issue:2 | Antifungal and cytotoxic activities of some N-substituted aniline derivatives bearing a hetaryl fragment. |
| AID1556225 | Inhibition of CYP51 in Candida albicans ATCC SC5314 assessed as lanosterol level at 2 ug/ml incubated for 16 hrs by GC/MS analysis (Rvb = 0%) | 2019 | European journal of medicinal chemistry, Sep-01, Volume: 177 | Design, synthesis, and structure-activity relationship studies of l-amino alcohol derivatives as broad-spectrum antifungal agents. |
| AID750772 | Antifungal activity against Aspergillus niger MTCC 1108 assessed as zone of inhibition at 80 uM after 48 hrs by disc diffusion method | 2013 | European journal of medicinal chemistry, Jun, Volume: 64 | Biological activity, design, synthesis and structure activity relationship of some novel derivatives of curcumin containing sulfonamides. |
| AID285694 | Serum trough levels in Wistar rat pup at 10 mg/kg of body weight/day, ip after 24 hrs by ELISA | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Neonatal coinfection model of coagulase-negative Staphylococcus (Staphylococcus epidermidis) and Candida albicans: fluconazole prophylaxis enhances survival and growth. |
| AID544876 | Antimicrobial activity against Candida dubliniensis harboring MRR1 CD57B mutant gene by microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | Gain-of-function mutations in the transcription factor MRR1 are responsible for overexpression of the MDR1 efflux pump in fluconazole-resistant Candida dubliniensis strains. |
| AID670737 | Antifungal activity against Cryptococcus gastricus MTCC 1715 by spectrophotometry based assay | 2012 | Bioorganic & medicinal chemistry letters, Jul-15, Volume: 22, Issue:14 | Synthesis and evaluation of novel 3a,9a-dihydro-1-ethoxycarbonyl-1-cyclopenteno[5,4-b]benzopyran-4-ones as antifungal agents. |
| AID279120 | Ratio of weight normalized daily dose in non-surviving candidemia patient to MIC at 24 hrs against Candida species | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Association of fluconazole area under the concentration-time curve/MIC and dose/MIC ratios with mortality in nonneutropenic patients with candidemia. |
| AID516275 | Antimicrobial activity against Cryptococcus gattii serotype B isolate RB-5 assessed as concentration required for heteroresistance | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Heteroresistance of Cryptococcus gattii to fluconazole. |
| AID406858 | Antimicrobial activity against Candida albicans SC5314 dissociated biofilms at cell density of 10'3 cells/ml after 48 hrs by XTT assay | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | Role for cell density in antifungal drug resistance in Candida albicans biofilms. |
| AID1054566 | Antifungal activity against Trichophyton mentagrophytes after 48 hrs by broth microdilution technique | 2013 | European journal of medicinal chemistry, , Volume: 70 | Azole-carbodithioate hybrids as vaginal anti-Candida contraceptive agents: design, synthesis and docking studies. |
| AID1370740 | Antifungal activity against Aspergillus fumigatus after 48 hrs by serial dilution method | 2018 | Bioorganic & medicinal chemistry letters, 02-01, Volume: 28, Issue:3 | Design, synthesis, and structure-activity relationship studies of novel tetrazole antifungal agents with potent activity, broad antifungal spectrum and high selectivity. |
| AID1543302 | Antimicrobial activity against Aspergillus fumigatus ATCC 90906 assessed as inhibition of microbial growth by CLSI based method | 2019 | Journal of natural products, 07-26, Volume: 82, Issue:7 | Anthraquinone-Based Specialized Metabolites from Rhizomes of |
| AID532538 | Antifungal activity against Saccharomyces cerevisiae BY4741 harboring human CYP51 assessed as accumulation of ergosterol at 16 ug/ml (Rvb = 54+/- 0.82 %) | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | Differential azole antifungal efficacies contrasted using a Saccharomyces cerevisiae strain humanized for sterol 14 alpha-demethylase at the homologous locus. |
| AID674387 | Antifungal activity against Chrysosporium keratinophilum MTCC 3017 at 0.5 mg/ml after 72 hrs by well plate method | 2012 | Bioorganic & medicinal chemistry letters, Jul-15, Volume: 22, Issue:14 | Synthesis of benzofuran based 1,3,5-substituted pyrazole derivatives: as a new class of potent antioxidants and antimicrobials--a novel accost to amend biocompatibility. |
| AID1595109 | Antifungal activity against Candida albicans assessed as reduction in fungal cell growth incubated for 24 and 72 hrs by cup plate method | 2019 | European journal of medicinal chemistry, May-15, Volume: 170 | Tetrazole hybrids and their antifungal activities. |
| AID279109 | Mortality rate stratified by 48 hrs MIC in dose-dependently susceptible Candida species infected patient | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Association of fluconazole area under the concentration-time curve/MIC and dose/MIC ratios with mortality in nonneutropenic patients with candidemia. |
| AID407016 | Antimicrobial activity against Cdr1, Cdr2 and Mdr1 deficient Candida albicans DSY1050 dissociated biofilms at cell density of 10'8 cells/ml after 48 hrs by XTT assay | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | Role for cell density in antifungal drug resistance in Candida albicans biofilms. |
| AID1369452 | Antifungal activity against fluconazole-resistant Candida albicans 17546 after 48 hrs by broth microdilution method | 2018 | Journal of medicinal chemistry, 05-10, Volume: 61, Issue:9 | Combating Drug-Resistant Fungi with Novel Imperfectly Amphipathic Palindromic Peptides. |
| AID50156 | In vitro evaluation of minimum inhibitory concentration against Candida krusei 70 | 1995 | Journal of medicinal chemistry, Sep-29, Volume: 38, Issue:20 | Synthesis and antifungal activity of new azole derivatives containing an N-acylmorpholine ring. |
| AID775727 | Antifungal activity against Fusarium oxysporum assessed as growth inhibition after 48 to 72 hrs by broth microdilution method | 2013 | European journal of medicinal chemistry, Nov, Volume: 69 | Microwave assisted synthesis of dihydrobenzo[4,5]imidazo[1,2-a]pyrimidin-4-ones; synthesis, in vitro antimicrobial and anticancer activities of novel coumarin substituted dihydrobenzo[4,5]imidazo[1,2-a]pyrimidin-4-ones. |
| AID1885993 | Antifungal activity against Cryptococcus neoformans clinical isolate HN17 assessed as fungal growth inhibition incubated for 72 hrs in presence of P163-0892 by broth microdilution method | |||
| AID1707520 | Induction of morphological changes in Candida albicans assessed as reduction in morphological conversion from yeast to hypha forms at 32 ug/ml incubated for 3 hrs by inverse fluorescence microscopy | 2021 | Journal of medicinal chemistry, 01-28, Volume: 64, Issue:2 | Novel Carboline Fungal Histone Deacetylase (HDAC) Inhibitors for Combinational Treatment of Azole-Resistant Candidiasis. |
| AID1885997 | Antifungal activity against Cryptococcus neoformans clinical isolate SH68 assessed as fungal growth inhibition incubated for 72 hrs in presence of P163-0892 by broth microdilution method | |||
| AID283227 | Effect on fungal burdens in Coccidioides immitis Silveira infected CD1 mouse spinal cord administered after 3 days of infection at 50 mg/kg, po bid after 12 days | 2007 | Antimicrobial agents and chemotherapy, Mar, Volume: 51, Issue:3 | Comparison of itraconazole and fluconazole treatments in a murine model of coccidioidal meningitis. |
| AID1864945 | Inhibition of CYP51 in Candida albicans ATCC SC5314 assessed as eburicol level at 4 ug/ml incuabted for 48 hrs by GC-MS analysis (Rvb = 1.05%) | |||
| AID609969 | Antifungal activity against Aspergillus niger at 1000 ug after 24 hrs by paper disc technique relative to control | 2011 | Bioorganic & medicinal chemistry letters, Aug-15, Volume: 21, Issue:16 | Efficient synthesis of antifungal active 9-substituted-3-aryl-5H,13aH-quinolino[3,2-f][1,2,4]triazolo[4,3-b][1,2,4]triazepines in ionic liquids. |
| AID405034 | Antifungal activity against Sporothrix schenckii PSCC1 isolate from cutaneous-lymphatic sporotrichosis patient after 72 hrs by Sensititre YeastOne method | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | In vitro susceptibility of Sporothrix schenckii to six antifungal agents determined using three different methods. |
| AID211473 | In vitro evaluation of minimum inhibitory concentration against Torulopsis glabrata 78 | 1995 | Journal of medicinal chemistry, Sep-29, Volume: 38, Issue:20 | Synthesis and antifungal activity of new azole derivatives containing an N-acylmorpholine ring. |
| AID405104 | Antimicrobial activity against Rhizopus arrhizus assessed as percent of susceptible isolates after 24 hrs | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | In vitro susceptibilities of 217 clinical isolates of zygomycetes to conventional and new antifungal agents. |
| AID599924 | Antifungal activity against Candida tropicalis after 96 hrs | 2011 | European journal of medicinal chemistry, Jun, Volume: 46, Issue:6 | Amberlite-IRA-402 (OH) ion exchange resin mediated synthesis of indolizines, pyrrolo [1,2-a] quinolines and isoquinolines: antibacterial and antifungal evaluation of the products. |
| AID9230 | In vitro antifungal activity against Aspergillus fumigatus 48238E | 2002 | Journal of medicinal chemistry, Oct-24, Volume: 45, Issue:22 | Synthesis, antifungal activity, and molecular modeling studies of new inverted oxime ethers of oxiconazole. |
| AID525598 | Antibacterial activity against Fluconazole resistant Candida albicans DSY296 overexpressing multidrug transporter gene CDR1 and CDR2 and containing ERG11 G464S mutation by EUCAST standards based broth microdilution method relative to wildtype sCandida alb | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Genetic dissection of azole resistance mechanisms in Candida albicans and their validation in a mouse model of disseminated infection. |
| AID1279030 | Antifungal activity against Trichosporon asahii 1188 after 48 hrs by microbroth dilution method | 2016 | Bioorganic & medicinal chemistry, Mar-15, Volume: 24, Issue:6 | Salicylanilide N-monosubstituted carbamates: Synthesis and in vitro antimicrobial activity. |
| AID518448 | Antimicrobial activity against Cryptococcus gattii serotype B isolate RB22 assessed as heteroresistant isolates at 4 ug/ml | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Heteroresistance of Cryptococcus gattii to fluconazole. |
| AID462239 | Antifungal activity against Candida albicans SA40 infected in Wistar rat estrogen-dependent fungal vaginitis model assessed as fungal burden at 10 ug administered intravaginally 48 hrs after fungal infection measured on day 7 after infection | 2010 | Journal of medicinal chemistry, Mar-25, Volume: 53, Issue:6 | Identification of inhibitors of drug-resistant Candida albicans strains from a library of bicyclic peptidomimetic compounds. |
| AID1572482 | Antifungal activity against Cryptococcus neoformans var. grubii H99 after 48 hrs by serial dilution method | 2019 | Bioorganic & medicinal chemistry, 03-01, Volume: 27, Issue:5 | Discovery of novel simplified isoxazole derivatives of sampangine as potent anti-cryptococcal agents. |
| AID1391615 | Antifungal activity against drug-resistant Candida albicans 28I after 48 hrs by broth microdilution method | 2018 | Bioorganic & medicinal chemistry letters, 05-15, Volume: 28, Issue:9 | Diversity-oriented synthesis of pyrazoles derivatives from flavones and isoflavones leads to the discovery of promising reversal agents of fluconazole resistance in Candida albicans. |
| AID490325 | Antimicrobial activity against Staphylococcus aureus ATCC 29213 at 4 ug/disk by disk diffusion method | 2010 | European journal of medicinal chemistry, Jul, Volume: 45, Issue:7 | Synthesis and biological evaluation of some thio containing pyrrolo [2,3-d]pyrimidine derivatives for their anti-inflammatory and anti-microbial activities. |
| AID1464193 | Anti-fungal activity against fluconazole-resistant Candida albicans isolate 103 by microbroth dilution method | 2017 | Bioorganic & medicinal chemistry letters, 10-01, Volume: 27, Issue:19 | Design, synthesis, and SAR study of 3-(benzo[d][1,3]dioxol-5-yl)-N-benzylpropanamide as novel potent synergists against fluconazole-resistant Candida albicans. |
| AID278384 | Antifungal activity against Candida lusitaniae 6936 revertant fcy2delta::[FCY2-URA3] by microdilution assay | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Molecular mechanism of flucytosine resistance in Candida lusitaniae: contribution of the FCY2, FCY1, and FUR1 genes to 5-fluorouracil and fluconazole cross-resistance. |
| AID1507062 | Antifungal activity against Candida utilis after 24 hrs by NCCLS two fold broth microdilution method | 2017 | European journal of medicinal chemistry, Aug-18, Volume: 136 | Design, synthesis and antimicrobial evaluation of novel benzimidazole-incorporated sulfonamide analogues. |
| AID518154 | Antimicrobial activity against Cryptococcus gattii serotype C isolate NIH187 assessed as concentration required for heteroresistance | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Heteroresistance of Cryptococcus gattii to fluconazole. |
| AID772320 | Antifungal activity against fluconazole-resistant Candida glabrata DSY754 increase expressing of CgCDR1 gene after 24 hrs by visually and spectrophotometric analysis | 2013 | ACS medicinal chemistry letters, Sep-12, Volume: 4, Issue:9 | Novel Macrocyclic Amidinoureas: Potent Non-Azole Antifungals Active against Wild-Type and Resistant Candida Species. |
| AID425150 | Antimicrobial activity against azole-resistant Candida albicans isolate CA10 assessed as growth at 0.016 ug/ml after 48 hrs by microdilution checkerboard technique relative to control | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | In vitro interactions between tacrolimus and azoles against Candida albicans determined by different methods. |
| AID1549167 | Inhibition of HDAC in azole-resistant Candida albicans 0304103 assessed as reduction in CDR1 gene expression at 32 ug/ml after 16 hrs by SYBR Green-1 dye based RT-PCR analysis | 2020 | Journal of medicinal chemistry, 05-28, Volume: 63, Issue:10 | Discovery of Novel Fungal Lanosterol 14α-Demethylase (CYP51)/Histone Deacetylase Dual Inhibitors to Treat Azole-Resistant Candidiasis. |
| AID467286 | Antifungal activity against Candida tropicalis by serial dilution method after 24 hrs | 2009 | Bioorganic & medicinal chemistry letters, Oct-15, Volume: 19, Issue:20 | Discovery of highly potent novel antifungal azoles by structure-based rational design. |
| AID527141 | Antifungal activity against Candida parapsilosis ATCC 22019 after 5 days microdilution technique | 2010 | Journal of natural products, Oct-22, Volume: 73, Issue:10 | Search for antifungal compounds from the wood of durable tropical trees. |
| AID365066 | Antifungal activity against Epidermophyton floccosum FF9 after 5 days by broth macrodilution method | 2008 | Bioorganic & medicinal chemistry, Sep-01, Volume: 16, Issue:17 | Antifungal activity of synthetic di(hetero)arylamines based on the benzo[b]thiophene moiety. |
| AID519682 | Antimicrobial activity against Saccharomyces cerevisiae containing disruption in YOR345C gene by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Genomewide screening for genes associated with gliotoxin resistance and sensitivity in Saccharomyces cerevisiae. |
| AID364275 | Antifungal activity against Candida albicans at 20 umol/ml after 48 hrs | 2008 | European journal of medicinal chemistry, Sep, Volume: 43, Issue:9 | Design, synthesis and characterization of some bioactive conjugates of curcumin with glycine, glutamic acid, valine and demethylenated piperic acid and study of their antimicrobial and antiproliferative properties. |
| AID1270920 | Antibiofilm activity against Candida albicans ATCC 24433 at 1000 ug/ml after 24 hrs by scanning electron microscopic analysis | 2015 | Journal of natural products, Nov-25, Volume: 78, Issue:11 | Synergistic Antifungal Meroterpenes and Dioxolanone Derivatives from the Endophytic Fungus Guignardia sp. |
| AID395831 | Antimicrobial activity against Klebsiella pneumoniae ATCC 27736 after 24 hrs by standard microbroth dilution assay | 2009 | European journal of medicinal chemistry, Jan, Volume: 44, Issue:1 | Tetrahydronaphthyl azole oxime ethers: the conformationally rigid analogues of oxiconazole as antibacterials. |
| AID1719769 | Antifungal activity against Cryptococcus neoformans H99 ATCC 208821 assessed as growth inhibition incubated for 36 hrs | |||
| AID582774 | Antifungal activity against Candida albicans isolate 12 harboring ERG3 W332R mutant gene assessed as 14alpha-methyl fecosterol content in total sterol composition at 0.5 times MIC by GC-MS analysis | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | Identification and characterization of four azole-resistant erg3 mutants of Candida albicans. |
| AID561417 | Antifungal activity against Candida lusitaniae 42720 by microdilution method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Nonsense and missense mutations in FCY2 and FCY1 genes are responsible for flucytosine resistance and flucytosine-fluconazole cross-resistance in clinical isolates of Candida lusitaniae. |
| AID71639 | In vitro antifungal activity against Fonsecaea pedrosoi | 2003 | Journal of medicinal chemistry, Feb-13, Volume: 46, Issue:4 | Structure-based de novo design, synthesis, and biological evaluation of non-azole inhibitors specific for lanosterol 14alpha-demethylase of fungi. |
| AID1474170 | Antifungal activity against Cryptococcus neoformans cgmcc 2.3161 by broth microdilution assay | 2016 | European journal of medicinal chemistry, Nov-10, Volume: 123 | Design, synthesis, and structure-activity relationship studies of benzothiazole derivatives as antifungal agents. |
| AID257548 | Antifungal activity against Aspergillus fumigatus | 2005 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 15, Issue:23 | Synthesis and biological evaluation of novel (L)-alpha-amino acid methyl ester, heteroalkyl, and aryl substituted 1,4-naphthoquinone derivatives as antifungal and antibacterial agents. |
| AID1820656 | Stability in human plasma assessed as half life incubated for 60 mins by LC-MS/MS analysis | 2022 | European journal of medicinal chemistry, Jan-15, Volume: 228 | Design, synthesis, and biological activity evaluation of 2-(benzo[b]thiophen-2-yl)-4-phenyl-4,5-dihydrooxazole derivatives as broad-spectrum antifungal agents. |
| AID1369489 | Antifungal activity against Candida albicans cgmcc 2.2086 in presence of 50% human heat-inactivated serum by broth dilution method | 2018 | Journal of medicinal chemistry, 05-10, Volume: 61, Issue:9 | Combating Drug-Resistant Fungi with Novel Imperfectly Amphipathic Palindromic Peptides. |
| AID1740331 | Antifungal activity against Stachybotrys chartarum IBT 7711 assessed as reduction in fungal growth incubated for 48 hrs by broth microdilution method | 2020 | European journal of medicinal chemistry, Sep-15, Volume: 202 | Design, synthesis and antimicrobial evaluation of novel glycosylated-fluoroquinolones derivatives. |
| AID1287611 | Antifungal activity against Candida parapsilosis ATCC 22019 after 18 to 24 hrs by micro-dilution method | 2016 | European journal of medicinal chemistry, May-04, Volume: 113 | Synthesis of newer 1,2,3-triazole linked chalcone and flavone hybrid compounds and evaluation of their antimicrobial and cytotoxic activities. |
| AID1742133 | Antifungal activity against fluconazole-resistant Candida albicans 632 assessed as inhibition of microbial growth by two fold broth microdilution method | 2020 | European journal of medicinal chemistry, Nov-01, Volume: 205 | Design, synthesis and bioactivity evaluation of novel arylalkene-amide derivatives as dual-target antifungal inhibitors. |
| AID420074 | Antifungal activity against Candida parapsilosis after 24 hrs by broth microdilution assay | 2009 | Bioorganic & medicinal chemistry, Jun-01, Volume: 17, Issue:11 | Bulky 1,4-benzoxazine derivatives with antifungal activity. |
| AID340966 | Antifungal activity against Rhodotorula sp. isolates from grapes by NCCLS M27-A2 method | 2007 | Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8 | Cross-resistance to medical and agricultural azole drugs in yeasts from the oropharynx of human immunodeficiency virus patients and from environmental Bavarian vine grapes. |
| AID613756 | Antifungal activity against Aspergillus fumigatus ATCC 46645 at 128 ug/ml by broth dilution method | 2011 | Bioorganic & medicinal chemistry letters, Aug-15, Volume: 21, Issue:16 | Novel hybrids of fluconazole and furanones: design, synthesis and antifungal activity. |
| AID584397 | Antifungal activity against 14 days cultured Candida krusei isolated from neutropenic subject with AML or MDS pharynx after 12 days of prophylaxis by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Impact of antifungal prophylaxis on colonization and azole susceptibility of Candida species. |
| AID518669 | Antimicrobial activity against Cryptococcus gattii serotype B isolate RAM15 assessed as heteroresistant isolates at 8 ug/ml | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Heteroresistance of Cryptococcus gattii to fluconazole. |
| AID1602386 | Antifungal activity against Cryptococcus neoformans H99 assessed as fragmented nuclei at 4 ug/ml after 24 hrs by TEM analysis | 2019 | Journal of medicinal chemistry, 03-14, Volume: 62, Issue:5 | Discovery of Carboline Derivatives as Potent Antifungal Agents for the Treatment of Cryptococcal Meningitis. |
| AID594942 | Antimicrobial activity against Microsporum gypseum after 7 days by NCCLS method | 2011 | European journal of medicinal chemistry, May, Volume: 46, Issue:5 | Design and synthesis of antifungal benzoheterocyclic derivatives by scaffold hopping. |
| AID419824 | Antifungal activity against Candida albicans at 100 ug after 48 hrs by agar disc-diffusion method | 2009 | European journal of medicinal chemistry, Jun, Volume: 44, Issue:6 | Synthesis and antimicrobial evaluation of 1-(benzofuran-2-yl)-4-nitro-3-arylbutan-1-ones and 3-(benzofuran-2-yl)-4,5-dihydro-5-aryl-1-[4-(aryl)-1,3-thiazol-2-yl]-1H-pyrazoles. |
| AID655716 | Antifungal activity against Curvularia lunata MTCC 581 at 40 uM/ml after 48 hrs by paper disc diffusion method | 2012 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 22, Issue:8 | Design, synthesis, synergistic antimicrobial activity and cytotoxicity of 4-aryl substituted 3,4-dihydropyrimidinones of curcumin. |
| AID538384 | Antifungal activity against Candida parapsilosis clinical isolate by serial dilution method | 2010 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 20, Issue:23 | Synthesis and in vitro antifungal activities of new 3-substituted benzopyrone derivatives. |
| AID1726244 | Antifungal activity against Candida pseudohaemulonis CBS 10004 by broth microdilution method | |||
| AID279703 | Effect on biofilm cell viability of Candida albicans K1 at 1000 ug/ml | 2007 | Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2 | Putative role of beta-1,3 glucans in Candida albicans biofilm resistance. |
| AID406956 | Therapeutic index, ratio of CC50 for human K562 cells to MIC90 for Candida albicans ATCC 10261 | 2008 | Journal of medicinal chemistry, Jul-10, Volume: 51, Issue:13 | 1-[(3-Aryloxy-3-aryl)propyl]-1H-imidazoles, new imidazoles with potent activity against Candida albicans and dermatophytes. Synthesis, structure-activity relationship, and molecular modeling studies. |
| AID372237 | Effect on CDR1 RNA level in Candida albicans CHK21 at MIC after 120 mins by RT-PCR | 2007 | Antimicrobial agents and chemotherapy, Oct, Volume: 51, Issue:10 | The Ssk1p response regulator and Chk1p histidine kinase mutants of Candida albicans are hypersensitive to fluconazole and voriconazole. |
| AID1303303 | Antimicrobial activity against Saccharomyces cerevisiae after 24 hrs by microbroth dilution method | 2016 | Bioorganic & medicinal chemistry letters, 06-01, Volume: 26, Issue:11 | Design, synthesis and biological evaluation of 5-fluorouracil-derived benzimidazoles as novel type of potential antimicrobial agents. |
| AID1465989 | Antifungal activity against Aspergillus fumigatus NR-35302 after 68 hrs by broth dilution assay | 2017 | Bioorganic & medicinal chemistry, 06-01, Volume: 25, Issue:11 | Investigation of aryl isonitrile compounds with potent, broad-spectrum antifungal activity. |
| AID566879 | Antifungal activity against Candida glabrata by microdilution test | 2011 | European journal of medicinal chemistry, Jan, Volume: 46, Issue:1 | Synthesis and antifungal activity of some substituted phenothiazines and related compounds. |
| AID1295986 | Selectivity index, ratio of IC50 for human HeLa cells to MIC for Candida albicans CAF2-1 | 2016 | Journal of natural products, Feb-26, Volume: 79, Issue:2 | Antifungal Quinoline Alkaloids from Waltheria indica. |
| AID553854 | Antifungal activity against fluconazole resistant Candida albicans isolate Gu5 overexpressing CDR1 and CDR2 in RPMI-1640 buffered medium after 24 hrs by microdilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | Enhanced susceptibility to antifungal oligopeptides in yeast strains overexpressing ABC multidrug efflux pumps. |
| AID424634 | Antimicrobial activity against azole-resistant Candida albicans isolate CA15 cotreated with calcineurin signaling inhibitor Tacrolimus after 48 hrs by microdilution checkerboard technique | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | In vitro interactions between tacrolimus and azoles against Candida albicans determined by different methods. |
| AID1156865 | Antimicrobial activity against Sporothrix schenckii after 72 hrs by microbroth dilution method | 2014 | European journal of medicinal chemistry, Aug-18, Volume: 83 | Synthesis of 2,3,6-trideoxy sugar triazole hybrids as potential new broad spectrum antimicrobial agents. |
| AID1762162 | Antifungal activity against Cryptococcus neoformans assessed as reduction in fungal growth incubated for 24 hrs by CLSI based serial microbroth dilution method | 2021 | Bioorganic & medicinal chemistry letters, 05-15, Volume: 40 | Synthesis and antifungal activity of new hybrids thiazolo[4,5-d]pyrimidines with (1H-1,2,4)triazole. |
| AID279112 | Ratio of AUC in surviving candidemia patient to MIC at 24 hrs against Candida species | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Association of fluconazole area under the concentration-time curve/MIC and dose/MIC ratios with mortality in nonneutropenic patients with candidemia. |
| AID341586 | Antimicrobial activity against 10'7 CFU Cryptococcus neoformans USC1597 isolate intracranially infected in Hartley guinea pig assessed as decrease in cerebrospinal fluid bacterial count per ml at 10 mg/kg, po BID administered 48 hrs postinfection for 13 d | 2007 | Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8 | New guinea pig model of Cryptococcal meningitis. |
| AID518429 | Antimicrobial activity against Cryptococcus gattii serotype B isolate NIH754 assessed as heteroresistant isolates at 4 ug/ml | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Heteroresistance of Cryptococcus gattii to fluconazole. |
| AID1156863 | Antimicrobial activity against Aspergillus fumigatus after 72 hrs by microbroth dilution method | 2014 | European journal of medicinal chemistry, Aug-18, Volume: 83 | Synthesis of 2,3,6-trideoxy sugar triazole hybrids as potential new broad spectrum antimicrobial agents. |
| AID1334856 | Inhibition of Candida albicans SC5314 CYP51 assessed as lanosterol composition of total sterols at 8 ug/ml by GC-MS method (Rvb = 3.5 %) | 2017 | Bioorganic & medicinal chemistry, 01-15, Volume: 25, Issue:2 | Discovery of biphenyl imidazole derivatives as potent antifungal agents: Design, synthesis, and structure-activity relationship studies. |
| AID518685 | Antimicrobial activity against Cryptococcus gattii serotype B isolate NIH444 assessed as heteroresistant isolates at 16 ug/ml | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Heteroresistance of Cryptococcus gattii to fluconazole. |
| AID555815 | Antifungal activity against tac1/tac1 deficient Candida albicans SZY31 after 48 hrs | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Relative contributions of the Candida albicans ABC transporters Cdr1p and Cdr2p to clinical azole resistance. |
| AID1326659 | Antifungal activity against Saccharomyces cerevisiae measured after 24 hrs by two-fold serial dilution method | 2016 | European journal of medicinal chemistry, Oct-21, Volume: 122 | Design, synthesis and biological evaluation of berberine-benzimidazole hybrids as new type of potentially DNA-targeting antimicrobial agents. |
| AID1549153 | Inhibition of CYP51 in azole-resistant Candida albicans 0304103 assessed as unknown sterol 1 level at 0.5 ug/ml after 24 hrs by GC-MS analysis (Rvb = 2.91%) | 2020 | Journal of medicinal chemistry, 05-28, Volume: 63, Issue:10 | Discovery of Novel Fungal Lanosterol 14α-Demethylase (CYP51)/Histone Deacetylase Dual Inhibitors to Treat Azole-Resistant Candidiasis. |
| AID1861420 | Antifungal activity against clinical strain Candida albicans CA4574 assessed as inhibition of fungal growth by microdilution method | 2022 | Bioorganic & medicinal chemistry letters, 09-01, Volume: 71 | Discovery of novel indole and indoline derivatives against Candida albicans as potent antifungal agents. |
| AID1639192 | Antibacterial activity against Mycobacterium tuberculosis H37Rv after 7 days by resazurin dye-based fluorescence assay | 2019 | Bioorganic & medicinal chemistry, 04-15, Volume: 27, Issue:8 | Synthesis and biological evaluation of novel cYY analogues targeting Mycobacterium tuberculosis CYP121A1. |
| AID1898178 | Antifungal activity against Candida auris 887 | |||
| AID1598036 | Antifungal activity against fluconalzole-susceptible Candida albicans after 24 hrs | 2019 | European journal of medicinal chemistry, May-15, Volume: 170 | Current advances of triazole alcohols derived from fluconazole: Design, in vitro and in silico studies. |
| AID283206 | Antimicrobial activity against polyene-resistant Candida glabrata 21229 isolate by E-test | 2007 | Antimicrobial agents and chemotherapy, Mar, Volume: 51, Issue:3 | Reduced susceptibility to polyenes associated with a missense mutation in the ERG6 gene in a clinical isolate of Candida glabrata with pseudohyphal growth. |
| AID527134 | Antifungal activity against Microsporum canis LMGO 02 after 5 days microdilution technique | 2010 | Journal of natural products, Oct-22, Volume: 73, Issue:10 | Search for antifungal compounds from the wood of durable tropical trees. |
| AID1154871 | Antifungal activity against Candida tropicalis after 7 days by serial dilution method | 2014 | ACS medicinal chemistry letters, May-08, Volume: 5, Issue:5 | Novel carboline derivatives as potent antifungal lead compounds: design, synthesis, and biological evaluation. |
| AID1595069 | Antifungal activity against Aspergillus niger assessed as inhibition zone at 20 ug/ml by disk diffusion method | 2019 | European journal of medicinal chemistry, May-15, Volume: 170 | Tetrazole hybrids and their antifungal activities. |
| AID434365 | Antifungal activity against Candida parapsilosis ATCC 22019 after 48 hrs by broth microdilution method | 2009 | European journal of medicinal chemistry, Aug, Volume: 44, Issue:8 | Design, synthesis and biological evaluation of novel nitrogen and sulfur containing hetero-1,4-naphthoquinones as potent antifungal and antibacterial agents. |
| AID417553 | Antifungal activity against Candida parapsilosis ATCC 22019 | 2009 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 19, Issue:5 | FR290581, a novel sordarin derivative: synthesis and antifungal activity. |
| AID257549 | Antifungal activity against Candida parapsilosis | 2005 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 15, Issue:23 | Synthesis and biological evaluation of novel (L)-alpha-amino acid methyl ester, heteroalkyl, and aryl substituted 1,4-naphthoquinone derivatives as antifungal and antibacterial agents. |
| AID772326 | Antifungal activity against fluconazole-resistant Candida albicans DSY348 harboring ERG11 gene mutant and increase expressing of CDR1 and CDR2 genes after 24 hrs by visually and spectrophotometric analysis | 2013 | ACS medicinal chemistry letters, Sep-12, Volume: 4, Issue:9 | Novel Macrocyclic Amidinoureas: Potent Non-Azole Antifungals Active against Wild-Type and Resistant Candida Species. |
| AID294416 | Antifungal activity against Aspergillus niger at 25 ug/mL by agar diffusion technique | 2007 | European journal of medicinal chemistry, Jul, Volume: 42, Issue:7 | Synthesis and antimicrobial evaluation of some new thiazole, thiazolidinone and thiazoline derivatives starting from 1-chloro-3,4-dihydronaphthalene-2-carboxaldehyde. |
| AID45329 | Evaluation of In vitro antifungal activity against Candida albicans C52 by broth macro dilution method | 1995 | Journal of medicinal chemistry, Sep-29, Volume: 38, Issue:20 | Synthesis and antifungal activity of new azole derivatives containing an N-acylmorpholine ring. |
| AID704469 | Antifungal activity against Candida krusei CLY 549 after 24 hrs by NCCLS broth microdilution method | 2012 | ACS medicinal chemistry letters, Oct-11, Volume: 3, Issue:10 | Antifungal spectrum, in vivo efficacy, and structure-activity relationship of ilicicolin h. |
| AID420082 | Antifungal activity against Candida albicans CA-6 infected in CD1 mouse assessed as reduction of fungal burden in kidneys at 10 mg/kg, ip pretreated 2 hrs before fungus-challenge and once daily for 6 days measured 7 days post-infection | 2009 | Bioorganic & medicinal chemistry, Jun-01, Volume: 17, Issue:11 | Bulky 1,4-benzoxazine derivatives with antifungal activity. |
| AID510308 | Antimicrobial activity against flucytosine, azole, and caspofungin resistant Candida glabrata bloodstream isolate 2 harboring Fur1 G109D mutation serially obtained from hematopoietic stem cell transplant recipient by Etest | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Acquisition of flucytosine, azole, and caspofungin resistance in Candida glabrata bloodstream isolates serially obtained from a hematopoietic stem cell transplant recipient. |
| AID545165 | Antimicrobial activity against Candida albicans isolate C after 48 hrs by EUCAST microdilution method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Breakthrough Aspergillus fumigatus and Candida albicans double infection during caspofungin treatment: laboratory characteristics and implication for susceptibility testing. |
| AID576546 | Antimicrobial activity against Candida albicans SC5314 biofilms infected in Sprague-Dawley rat implanted subcutaneously with catheter fragments challenged Candida cells assessed as bacterial load at 125 mg/kg, ip qd for 7 days (Rvb=2.92 +/- 0.34 log10 CFU | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10 | In vivo efficacy of anidulafungin against mature Candida albicans biofilms in a novel rat model of catheter-associated Candidiasis. |
| AID1309057 | Antifungal activity against Aspergillus nidulans ATCC 38163 after 48 hrs by CLSI M38-A2 method | 2016 | Bioorganic & medicinal chemistry, 08-15, Volume: 24, Issue:16 | Synthesis and investigation of novel benzimidazole derivatives as antifungal agents. |
| AID1609938 | Inhibition of Candida albicans CYP51 assessed as increase in sterol level at 0.25 ug/ml incubated for 18 hrs by GC/MS analysis relative to control | |||
| AID285698 | Serum trough levels in Wistar rat pup at 10 mg/kg of body weight/day, ip after 144 hrs by ELISA | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Neonatal coinfection model of coagulase-negative Staphylococcus (Staphylococcus epidermidis) and Candida albicans: fluconazole prophylaxis enhances survival and growth. |
| AID392367 | Antifungal activity against Trichophyton mentagrophytes 445 after 24 hrs by broth microdilution method | 2009 | Bioorganic & medicinal chemistry letters, Jan-15, Volume: 19, Issue:2 | Salicylanilide esters of N-protected amino acids as novel antimicrobial agents. |
| AID48569 | Minimum concentration required to inhibit the growth of Candida albicans ATCC 24433 was determined in the presence of horse serum (20%); NT means not tested | 2002 | Bioorganic & medicinal chemistry letters, Oct-07, Volume: 12, Issue:19 | Synthesis and evaluation of novel pyrrolidinyl sordaricin derivatives as antifungal agents. |
| AID518695 | Antimicrobial activity against Cryptococcus gattii serotype B isolate RAM15 assessed as heteroresistant isolates at 16 ug/ml | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Heteroresistance of Cryptococcus gattii to fluconazole. |
| AID518420 | Antimicrobial activity against Cryptococcus gattii serotype C isolate NIH113 assessed as heteroresistant isolates at 2 ug/ml | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Heteroresistance of Cryptococcus gattii to fluconazole. |
| AID547615 | Antifungal activity against Candida glabrata isolate Cg16R with CgPDR1 R772I mutant | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | Microarray and molecular analyses of the azole resistance mechanism in Candida glabrata oropharyngeal isolates. |
| AID725885 | Antifungal activity against fluconazole-susceptible Candida albicans CAAL93 after 24 hrs by spectrofluorometric analysis | 2013 | ACS medicinal chemistry letters, Feb-14, Volume: 4, Issue:2 | Discovery of a novel broad-spectrum antifungal agent derived from albaconazole. |
| AID752003 | Antifungal activity against Aspergillus flavus NCIM 539 by agar dilution method | 2013 | Bioorganic & medicinal chemistry letters, May-01, Volume: 23, Issue:9 | Green synthesis of tetrahydropyrimidine analogues and evaluation of their antimicrobial activity. |
| AID1877316 | Cytotoxicity against human MCF7 cells assessed as inhibition of cell growth incubated for 4 hrs by MTT assay | 2022 | European journal of medicinal chemistry, Jan-05, Volume: 227 | Broadening antifungal spectrum and improving metabolic stablity based on a scaffold strategy: Design, synthesis, and evaluation of novel 4-phenyl-4,5-dihydrooxazole derivatives as potent fungistatic and fungicidal reagents. |
| AID1905261 | Antifungal activity against fluconazole-resistant Candida albicans 100 assessed as inhibition of fungal growth by checker board microdilution assay | 2022 | Journal of medicinal chemistry, 04-14, Volume: 65, Issue:7 | Species-Selective Targeting of Fungal Hsp90: Design, Synthesis, and Evaluation of Novel 4,5-Diarylisoxazole Derivatives for the Combination Treatment of Azole-Resistant Candidiasis. |
| AID1487220 | Inhibition of CYP2C19 in human hepatocyte microsomes using omeprazole substrate by HPLC/MS/MS method | 2017 | Bioorganic & medicinal chemistry letters, 08-01, Volume: 27, Issue:15 | Design and optimization of highly-selective, broad spectrum fungal CYP51 inhibitors. |
| AID1600172 | Antifungal activity against Aspergillus niger NCIM 504 assessed as inhibition of fungal growth incubated for 48 to 72 hrs by broth microdilution susceptibility method | 2019 | European journal of medicinal chemistry, Oct-01, Volume: 179 | Synthesis of new thiazolyl-pyrazolyl-1,2,3-triazole derivatives as potential antimicrobial agents. |
| AID453449 | Antifungal activity against Candida krusei ATCC 6258 after 48 hrs by broth microdilution method | 2010 | Bioorganic & medicinal chemistry letters, Jan-15, Volume: 20, Issue:2 | Fluconazole analogues containing 2H-1,4-benzothiazin-3(4H)-one or 2H-1,4-benzoxazin-3(4H)-one moieties, a novel class of anti-Candida agents. |
| AID262546 | Antifungal activity against Candida albicans | 2006 | Journal of medicinal chemistry, Apr-20, Volume: 49, Issue:8 | Structure-based optimization of azole antifungal agents by CoMFA, CoMSIA, and molecular docking. |
| AID1359823 | Antifungal activity against Cryptococcus neoformans ATCC 32719 measured after 48 hrs by two-dimensional broth microdilution checkboard method | |||
| AID1888266 | Antifungal activity against fluconazole resistant Candida albicans strain 901 assessed as fungal growth inhibition measured after 72 hrs by CLSI protocol based liquid medium dilution method | |||
| AID407064 | Antimicrobial activity against Candida albicans disaggregated biofilms | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | Role for cell density in antifungal drug resistance in Candida albicans biofilms. |
| AID486714 | Antifungal activity against Candida krusei ATCC 30068 after 24 hrs by macrodilution method | 2010 | European journal of medicinal chemistry, Jun, Volume: 45, Issue:6 | Design, synthesis and determination of antifungal activity of 5(6)-substituted benzotriazoles. |
| AID1738743 | Inhibition of CYP51 in azole-resistant Candida albicans ATCC SC531 assessed as Eburicol level at 0.03125 ug/ml incubated for 16 hrs by LC-MS analysis relative to control | 2020 | European journal of medicinal chemistry, Jul-15, Volume: 198 | Design, synthesis, and biological evaluation of novel miconazole analogues containing selenium as potent antifungal agents. |
| AID245492 | In vitro concentration required to inhibit 80% growth of Saccharomyces cerevisiae strain YEM139 (PDR5 deleted) after 48 h | 2004 | Bioorganic & medicinal chemistry letters, Oct-18, Volume: 14, Issue:20 | Quinazolinone fungal efflux pump inhibitors. Part 2: In vitro structure-activity relationships of (N-methyl-piperazinyl)-containing derivatives. |
| AID1510727 | Antibacterial activity against Pseudomonas aeruginosa | 2019 | European journal of medicinal chemistry, Oct-01, Volume: 179 | Nitroimidazole-containing compounds and their antibacterial and antitubercular activities. |
| AID518677 | Antimicrobial activity against Cryptococcus gattii serotype C isolate NIH191 assessed as heteroresistant isolates at 8 ug/ml | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Heteroresistance of Cryptococcus gattii to fluconazole. |
| AID762387 | Antifungal activity against Candida glabrata ATCC 90030 after 24 to 72 hrs by microdilution method | 2013 | European journal of medicinal chemistry, Aug, Volume: 66 | Synthesis, in vitro antifungal activity and in silico study of 3-(1,2,4-triazol-1-yl)flavanones. |
| AID1491241 | Antifungal activity against Candida albicans CPCC 400523 by broth microdilution method | 2017 | European journal of medicinal chemistry, Sep-08, Volume: 137 | Design, synthesis and evaluation of aromatic heterocyclic derivatives as potent antifungal agents. |
| AID1918351 | Induction of apoptosis in Candida albicans assessed as early apoptotic cells measured after 24 hrs by Annexin V-FITC/PI staining based flow cytometry (Rvb = 0.46%) | 2022 | Journal of medicinal chemistry, 11-10, Volume: 65, Issue:21 | Novel Aryl Alkamidazole Derivatives as Multifunctional Antifungal Inhibitors: Design, Synthesis, and Biological Evaluation. |
| AID1628382 | Antimicrobial activity against Pseudomonas aeruginosa ATCC 27853 incubated for 24 hrs by NCCLS protocol based method | 2016 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 26, Issue:12 | Discovery of novel berberine imidazoles as safe antimicrobial agents by down regulating ROS generation. |
| AID1783813 | Inhibition of Candida albicans CYP51 assessed as unknown sterol level at 0.25 ug/ml measured after 18 hrs by GC-MS analysis relative to control | 2021 | European journal of medicinal chemistry, Nov-15, Volume: 224 | Improving the metabolic stability of antifungal compounds based on a scaffold hopping strategy: Design, synthesis, and structure-activity relationship studies of dihydrooxazole derivatives. |
| AID1674374 | Half life in human | 2020 | Journal of medicinal chemistry, 11-12, Volume: 63, Issue:21 | Integrating the Impact of Lipophilicity on Potency and Pharmacokinetic Parameters Enables the Use of Diverse Chemical Space during Small Molecule Drug Optimization. |
| AID1864924 | Toxicity in mouse infected with Candida albicans assessed as AST level in plasma at 10 ug per 20 g, ip administered on day 2, 4, 6, 8, 10 and 12 and measured on day 14 in presence of naproxen (Rvb = 74.9 +/- 6.7 IU/L) | |||
| AID1061742 | Antimicrobial activity against Candida albicans SC5314 after 24 hrs by broth microdilution method | 2014 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 24, Issue:1 | Synthesis and evaluation of novel azoles as potent antifungal agents. |
| AID1602372 | Antifungal activity against Cryptococcus neoformans ATCC 34877 after 72 hrs by spectrophotometery | 2019 | Journal of medicinal chemistry, 03-14, Volume: 62, Issue:5 | Discovery of Carboline Derivatives as Potent Antifungal Agents for the Treatment of Cryptococcal Meningitis. |
| AID424656 | Antimicrobial activity against azole-resistant Candida albicans isolate CA10 assessed as growth at 16 ug/ml cotreated with 0.063 ug/ml calcineurin signaling inhibitor tacrolimus after 48 hrs by microdilution checkerboard technique relative to control | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | In vitro interactions between tacrolimus and azoles against Candida albicans determined by different methods. |
| AID1610305 | Antifungal activity against Candida zeylanoides CGMCC2.3739 measured at 24 hrs by CLSI protocol based microbroth dilution method | 2019 | Bioorganic & medicinal chemistry letters, 12-01, Volume: 29, Issue:23 | Design, synthesis and biological evaluation of novel semicarbazone-selenochroman-4-ones hybrids as potent antifungal agents. |
| AID1419526 | Effect on sterol composition in Candida albicans ATCC 64124 assessed as lanosterol level at 0.125 ug/mL incubated for 10 mins by LC-MS analysis (Rvb = 29.38%) | 2017 | European journal of medicinal chemistry, Jun-16, Volume: 133 | Novel alkylated azoles as potent antifungals. |
| AID1595081 | Antifungal activity against Candida albicans assessed as reduction in fungal cell growth incubated for 24 hrs by broth microdilution method | 2019 | European journal of medicinal chemistry, May-15, Volume: 170 | Tetrazole hybrids and their antifungal activities. |
| AID1877279 | Antifungal activity against Candida albicans ATCC SC5314 assessed as fungal growth inhibition by NCCLS protocol based method | 2022 | European journal of medicinal chemistry, Jan-05, Volume: 227 | Broadening antifungal spectrum and improving metabolic stablity based on a scaffold strategy: Design, synthesis, and evaluation of novel 4-phenyl-4,5-dihydrooxazole derivatives as potent fungistatic and fungicidal reagents. |
| AID440341 | Antifungal activity against Aspergillus flavus NCIM 524 at 10 ug/ml after 2 to 3 days by serial plate dilution method | 2009 | European journal of medicinal chemistry, Dec, Volume: 44, Issue:12 | Synthesis and antimicrobial activity of some new N-acyl substituted phenothiazines. |
| AID444050 | Fraction unbound in human plasma | 2010 | Journal of medicinal chemistry, Feb-11, Volume: 53, Issue:3 | Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. |
| AID547616 | Antifungal activity against Candida glabrata isolate Cg5S | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | Microarray and molecular analyses of the azole resistance mechanism in Candida glabrata oropharyngeal isolates. |
| AID1357632 | Antifungal activity against Candida krusei ATCC 20298 after 48 hrs by microbroth dilution assay | 2018 | European journal of medicinal chemistry, May-10, Volume: 151 | Synthesis, molecular modeling studies and evaluation of antifungal activity of a novel series of thiazole derivatives. |
| AID1246679 | Antifungal activity against Cryptococcus neoformans VM-MCMMPI assessed as reduction in cell viability at 26 uM after 6 to 72 hrs by MTT assay | 2015 | European journal of medicinal chemistry, Sep-18, Volume: 102 | Thiazole compounds with activity against Cryptococcus gattii and Cryptococcus neoformans in vitro. |
| AID1584736 | Drug metabolism in mouse liver microsome S9 fraction assessed as CYP450-mediated metabolism by measuring compound remaining at 5 uM pretreated with NADPH and measured after 60 mins by UPLC-MS/MS analysis | 2018 | Journal of medicinal chemistry, 10-25, Volume: 61, Issue:20 | Discovery of Novel 7-Aryl 7-Deazapurine 3'-Deoxy-ribofuranosyl Nucleosides with Potent Activity against Trypanosoma cruzi. |
| AID279128 | Ratio of AUC in non-surviving candidemia patient to MIC at 48 hrs against Candida species | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Association of fluconazole area under the concentration-time curve/MIC and dose/MIC ratios with mortality in nonneutropenic patients with candidemia. |
| AID395783 | Antifungal activity against Candida albicans ATCC 10231 after 48 hrs by twofold serial dilution technique | 2008 | European journal of medicinal chemistry, Nov, Volume: 43, Issue:11 | Synthesis, antimicrobial activity, pharmacophore analysis of some new 2-(substitutedphenyl/benzyl)-5-[(2-benzofuryl)carboxamido]benzoxazoles. |
| AID440338 | Antifungal activity against Candida albicans NCIM 300 at 10 ug/ml after 2 to 3 days by serial plate dilution method | 2009 | European journal of medicinal chemistry, Dec, Volume: 44, Issue:12 | Synthesis and antimicrobial activity of some new N-acyl substituted phenothiazines. |
| AID1493837 | Antifungal activity against fluconazole-resistant Candida albicans isolate J38 clinical isolate after 24 hrs by spectrophotometric analysis | 2018 | European journal of medicinal chemistry, Jan-01, Volume: 143 | Discovery of simplified sampangine derivatives as novel fungal biofilm inhibitors. |
| AID1719183 | Antifungal activity against fluconazole-resistant Candida albicans F5 assessed as reduction in microbial growth | 2021 | Bioorganic & medicinal chemistry letters, 03-01, Volume: 35 | A new 1-nitro-9-aminoacridine derivative targeting yeast topoisomerase II able to overcome fluconazole-resistance. |
| AID1864901 | Antifungal activity against fluconazole- resistant Candida albicans 632 assessed as fungal growth inhibition measured after 72 hrs in presence of naproxen by double dilution method | |||
| AID467908 | Antifungal activity against Candida parapsilosis after 48 hrs by broth microdilution technique | 2010 | European journal of medicinal chemistry, Feb, Volume: 45, Issue:2 | Imidazole derivatives as possible microbicides with dual protection. |
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| AID347891 | Antimicrobial activity against Aspergillus fumigatus ATCC 10894 | 2009 | Bioorganic & medicinal chemistry, Jan-15, Volume: 17, Issue:2 | Pestalofones A-E, bioactive cyclohexanone derivatives from the plant endophytic fungus Pestalotiopsis fici. |
| AID540213 | Half life in human after iv administration | 2008 | Drug metabolism and disposition: the biological fate of chemicals, Jul, Volume: 36, Issue:7 | Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. |
| AID1877825 | Antifungal activity against Candida albicans SC5314 by microdilution method | 2022 | Bioorganic & medicinal chemistry letters, 02-15, Volume: 58 | Synthesis and antifungal evaluation of phenol-derived bis(indolyl)methanes combined with FLC against Candida albicans. |
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| AID568490 | Antifungal activity against Candida albicans ATCC 76615 by twofold broth dilution method | 2011 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 21, Issue:3 | Synthesis and evaluation of a class of new coumarin triazole derivatives as potential antimicrobial agents. |
| AID1465982 | Antifungal activity against Candida tropicalis ATCC 13803 after 44 hrs by broth dilution assay | 2017 | Bioorganic & medicinal chemistry, 06-01, Volume: 25, Issue:11 | Investigation of aryl isonitrile compounds with potent, broad-spectrum antifungal activity. |
| AID1138346 | Antimicrobial activity against Candida albicans SC5314 infected in ICR mouse assessed as mean survival days at 0.5 mg/kg, po qd for 5 days starting 2 hrs post infection (Rvb = 9.0 +/- 0.67 days) | 2014 | Journal of medicinal chemistry, May-08, Volume: 57, Issue:9 | Design, synthesis, and structure-activity relationship studies of novel fused heterocycles-linked triazoles with good activity and water solubility. |
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| AID1820638 | Antifungal activity against Candida albicans GIM 2.194 assessed as inhibition of fungal growth by NCCLS protocol based method | 2022 | European journal of medicinal chemistry, Jan-15, Volume: 228 | Design, synthesis, and biological activity evaluation of 2-(benzo[b]thiophen-2-yl)-4-phenyl-4,5-dihydrooxazole derivatives as broad-spectrum antifungal agents. |
| AID1507063 | Antifungal activity against Saccharomyces cerevisiae after 24 hrs by NCCLS two fold broth microdilution method | 2017 | European journal of medicinal chemistry, Aug-18, Volume: 136 | Design, synthesis and antimicrobial evaluation of novel benzimidazole-incorporated sulfonamide analogues. |
| AID208062 | In vitro antifungal activity against Trichophyton mentagrophytes CM84 | 2002 | Journal of medicinal chemistry, Oct-24, Volume: 45, Issue:22 | Synthesis, antifungal activity, and molecular modeling studies of new inverted oxime ethers of oxiconazole. |
| AID19424 | Partition coefficient (logD7.4) | 2001 | Journal of medicinal chemistry, Jul-19, Volume: 44, Issue:15 | ElogD(oct): a tool for lipophilicity determination in drug discovery. 2. Basic and neutral compounds. |
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| AID1886032 | Synergistic antifungal activity against Candida albicans SC5314 assessed as fractional inhibitory concentration index incubated for 48 hrs in presence of P163-0892 by broth microdilution method | |||
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| AID1542743 | Antifungal activity against Cryptococcus neoformans ATCC 208821 measured after 36 hrs by resazurin dye based assay | 2019 | Bioorganic & medicinal chemistry, 05-15, Volume: 27, Issue:10 | 6-Bromoindolglyoxylamido derivatives as antimicrobial agents and antibiotic enhancers. |
| AID1168326 | Binding affinity to human serum albumin assessed as formation of non-fluorescent compound-protein complex at 310 K at pH 7.4 by fluorescence quenching method | 2014 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 24, Issue:21 | Study the interactions between human serum albumin and two antifungal drugs: fluconazole and its analogue DTP. |
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| AID1758006 | Antifungal activity against Candida glabrata measured after 24 hrs by broth microdilution assay | 2021 | European journal of medicinal chemistry, Apr-15, Volume: 216 | Lead optimization generates selenium-containing miconazole CYP51 inhibitors with improved pharmacological profile for the treatment of fungal infections. |
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| AID340961 | Antifungal activity against Candida albidus isolates from grapes by NCCLS M27-A2 method | 2007 | Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8 | Cross-resistance to medical and agricultural azole drugs in yeasts from the oropharynx of human immunodeficiency virus patients and from environmental Bavarian vine grapes. |
| AID563611 | Effect on sterol composition in Candida albicans isolate 108 harboring erg11 and erg5 double mutant assessed as ergosta 5,7-dienol level after 2 hrs by gas chromatography | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | A clinical isolate of Candida albicans with mutations in ERG11 (encoding sterol 14alpha-demethylase) and ERG5 (encoding C22 desaturase) is cross resistant to azoles and amphotericin B. |
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| AID560144 | Antifungal activity against Candida glabrata isolate 22852 by Etest method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Hypersusceptibility to azole antifungals in a clinical isolate of Candida glabrata with reduced aerobic growth. |
| AID493512 | Antifungal activity against Candida albicans ATCC 44859 after 48 hrs by broth microdilution assay | 2010 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 20, Issue:15 | N-Benzylsalicylthioamides as novel compounds with promising antimycotic activity. |
| AID1728515 | Inhibition of CYP51 in Candida albicans ATCC SC5314 assessed as eburicol level at 0.125 ug/ml incubated for 48 hrs by LC/MS analysis (Rvb = 1.4 %) | 2021 | European journal of medicinal chemistry, Jan-15, Volume: 210 | Novel naphthylamide derivatives as dual-target antifungal inhibitors: Design, synthesis and biological evaluation. |
| AID1743172 | Antifungal activity against Microsporum canis | 2020 | European journal of medicinal chemistry, Dec-15, Volume: 208 | Multiple biological active 4-aminopyrazoles containing trifluoromethyl and their 4-nitroso-precursors: Synthesis and evaluation. |
| AID1176266 | Antifungal activity against Epidermophyton floccosum after 2 to 7 days by serial plate dilution method | 2015 | Bioorganic & medicinal chemistry letters, Jan-15, Volume: 25, Issue:2 | Ionic liquid catalyzed synthesis of 2-(indole-3-yl)-thiochroman-4-ones and their novel antifungal activities. |
| AID545269 | Antifungal activity against Candida tropicalis 156 after 48 hrs by broth microdilution method | 2010 | European journal of medicinal chemistry, Dec, Volume: 45, Issue:12 | New amino acid esters of salicylanilides active against MDR-TB and other microbes. |
| AID595736 | Antimicrobial activity against Candida parapsilosis after 48 hrs by broth microdilution method | 2011 | European journal of medicinal chemistry, May, Volume: 46, Issue:5 | Design, synthesis and in vitro antimicrobial evaluation of novel Imidazo[1,2-a]pyridine and imidazo[2,1-b][1,3]benzothiazole motifs. |
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| AID1783062 | Antifungal activity against fluconazole-resistant Candida tropicalis 5008 assessed as inhibition of fungal growth incubated for 48 hrs by two-fold serial microdilution method | 2021 | European journal of medicinal chemistry, Oct-05, Volume: 221 | Lanosterol 14α-demethylase (CYP51)/histone deacetylase (HDAC) dual inhibitors for treatment of Candida tropicalis and Cryptococcus neoformans infections. |
| AID432099 | Antifungal activity against Penicillium at 10 ug/ml for 48 hrs by disc diffusion method | 2009 | European journal of medicinal chemistry, Sep, Volume: 44, Issue:9 | Synthesis, spectral characterization, in-vitro microbiological evaluation and cytotoxic activities of novel macrocyclic bis hydrazone. |
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| AID1885963 | Antifungal activity against Candida tropicalis ATCC20026 assessed as fungal growth inhibition incubated for 48 hrs by broth microdilution method | |||
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| AID549052 | Antifungal activity against Candida albicans CA137 after 48 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | In vitro activities of retigeric acid B alone and in combination with azole antifungal agents against Candida albicans. |
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| AID555137 | Antimicrobial activity against Candida parapsilosis ATCC 22019 by CLSI M27-A2 broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Fenticonazole activity measured by the methods of the European Committee on Antimicrobial Susceptibility Testing and CLSI against 260 Candida vulvovaginitis isolates from two European regions and annotations on the prevalent genotypes. |
| AID48059 | Compound was tested for antifungal activity against growth of two strains Candida parapsilosis | 2000 | Bioorganic & medicinal chemistry letters, Apr-17, Volume: 10, Issue:8 | Synthesis and antifungal activity of a ferrocene-fluconazole analogue. |
| AID285860 | Antimicrobial susceptibility of Pichia anomala from nosocomial fungemia patient assessed as percent susceptible isolates at 4 ug/ml by CLSI method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Antifungal drug susceptibility profile of Pichia anomala isolates from patients presenting with nosocomial fungemia. |
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| AID598293 | Antimicrobial activity against Candida glabrata isolate 32 after 48 hrs by microdilution broth method | 2011 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 21, Issue:11 | Synthesis and in vitro antimicrobial activities of new (cyano-NNO-azoxy)pyrazole derivatives. |
| AID1281698 | Antifungal activity against Saccharomyces cerevisiae ATCC 9763 after 24 hrs by micro broth dilution method | 2016 | European journal of medicinal chemistry, Mar-23, Volume: 111 | Discovery of membrane active benzimidazole quinolones-based topoisomerase inhibitors as potential DNA-binding antimicrobial agents. |
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| AID1859333 | Antimicrobial activity against Candida krusei ATCC 2340 | 2022 | Journal of medicinal chemistry, 02-24, Volume: 65, Issue:4 | Application of the All-Hydrocarbon Stapling Technique in the Design of Membrane-Active Peptides. |
| AID47585 | Evaluation of In vitro antifungal activity against Candida albicans C52 by broth macro dilution method | 1995 | Journal of medicinal chemistry, Sep-29, Volume: 38, Issue:20 | Synthesis and antifungal activity of new azole derivatives containing an N-acylmorpholine ring. |
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| AID766640 | Antifungal activity against Issatchenkia orientalis MTCC 3020 after 24 hrs by well diffusion method | 2013 | European journal of medicinal chemistry, Sep, Volume: 67 | Total synthesis and biological evaluation of clavaminol-G and its analogs. |
| AID1493838 | Antifungal activity against fluconazole-resistant Candida albicans isolate Chang7 clinical isolate after 24 hrs by spectrophotometric analysis | 2018 | European journal of medicinal chemistry, Jan-01, Volume: 143 | Discovery of simplified sampangine derivatives as novel fungal biofilm inhibitors. |
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| AID1465988 | Antifungal activity against Aspergillus niger ATCC 16888 after 68 hrs by broth dilution assay | 2017 | Bioorganic & medicinal chemistry, 06-01, Volume: 25, Issue:11 | Investigation of aryl isonitrile compounds with potent, broad-spectrum antifungal activity. |
| AID719030 | Antifungal activity against Candida krusei E28 assessed as growth inhibition after 48 hrs by CLSI M27-A2 broth microdilution method | 2012 | Bioorganic & medicinal chemistry, Dec-15, Volume: 20, Issue:24 | Anti-infective and herbicidal activity of N-substituted 2-aminobenzothiazoles. |
| AID1060931 | Antimicrobial activity against Candida albicans after 24 hrs by two-fold serial dilution method | 2014 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 24, Issue:1 | 1,2,3-Triazole-derived naphthalimides as a novel type of potential antimicrobial agents: synthesis, antimicrobial activity, interaction with calf thymus DNA and human serum albumin. |
| AID1549173 | Antifungal activity against Candida albicans 0304103 assessed as effect on filamentation up to 32 ug/ml after 4 hrs by differential interference contrast microscopic analysis | 2020 | Journal of medicinal chemistry, 05-28, Volume: 63, Issue:10 | Discovery of Novel Fungal Lanosterol 14α-Demethylase (CYP51)/Histone Deacetylase Dual Inhibitors to Treat Azole-Resistant Candidiasis. |
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| AID608675 | Antifungal activity against Candida albicans at 500 ug/ml after 72 hrs by agar diffusion method | 2011 | European journal of medicinal chemistry, Aug, Volume: 46, Issue:8 | Synthesis, characterization and antimicrobial studies of some new pyrazole incorporated imidazole derivatives. |
| AID1546134 | Antimicrobial activity against Escherichia coli JM 109 after 24 hrs by two-fold broth serial dilution method | 2019 | European journal of medicinal chemistry, Dec-15, Volume: 184 | Current scenario of tetrazole hybrids for antibacterial activity. |
| AID1607697 | Antifungal activity against Aspergillus niger MTCC 282 after 120 hrs by serial tube dilution method | 2019 | European journal of medicinal chemistry, Sep-15, Volume: 178 | An overview on the synthetic and medicinal perspectives of indenopyrazoles. |
| AID518688 | Antimicrobial activity against Cryptococcus gattii serotype B isolate NIH367 assessed as heteroresistant isolates at 16 ug/ml | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Heteroresistance of Cryptococcus gattii to fluconazole. |
| AID1369456 | Fungicidal activity against Candida albicans cgmcc 2.2086 after 96 hrs | 2018 | Journal of medicinal chemistry, 05-10, Volume: 61, Issue:9 | Combating Drug-Resistant Fungi with Novel Imperfectly Amphipathic Palindromic Peptides. |
| AID1391607 | Antifungal activity against CDR1 and CDR2 efflux pump deficient Candida albicans DSY654 after 48 hrs by broth microdilution method | 2018 | Bioorganic & medicinal chemistry letters, 05-15, Volume: 28, Issue:9 | Diversity-oriented synthesis of pyrazoles derivatives from flavones and isoflavones leads to the discovery of promising reversal agents of fluconazole resistance in Candida albicans. |
| AID667135 | Antifungal activity against Candida albicans MTCC 183 after 48 hrs by serial dilution method | 2012 | Bioorganic & medicinal chemistry letters, Jul-01, Volume: 22, Issue:13 | Regioselective synthesis and antimicrobial studies of ester linked 1,4-disubstituted 1,2,3-bistriazoles. |
| AID1609933 | Antifungal activity against fluconazole-resistant Candida albicans 904 assessed as reduction in fungal growth incubated for 24 hrs by serial dilution method | |||
| AID530977 | Antifungal activity against Aspergillus flavus ATCC 204304 at 163.3 uM after 48 hrs by CLSI method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Potent in vitro antifungal activities of naturally occurring acetylenic acids. |
| AID553855 | Antifungal activity against fluconazole sensitive Candida albicans isolate B3 in RPMI-1640 buffered medium after 24 hrs by microdilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | Enhanced susceptibility to antifungal oligopeptides in yeast strains overexpressing ABC multidrug efflux pumps. |
| AID1304741 | Antifungal activity against Microsporum gypseum measured after 7 days by serial dilution method | 2016 | Journal of medicinal chemistry, Apr-14, Volume: 59, Issue:7 | Discovery of Potent Benzofuran-Derived Diapophytoene Desaturase (CrtN) Inhibitors with Enhanced Oral Bioavailability for the Treatment of Methicillin-Resistant Staphylococcus aureus (MRSA) Infections. |
| AID489936 | Antifungal activity against Candida tropicalis TIMM 0313 after 24 hrs by microdilution method | 2010 | Bioorganic & medicinal chemistry letters, Jul-01, Volume: 20, Issue:13 | Novel pyridobenzimidazole derivatives exhibiting antifungal activity by the inhibition of beta-1,6-glucan synthesis. |
| AID1331130 | Antibiofilm activity against Candida albicans ATCC 10231 after 24 hrs by XTT reduction assay | |||
| AID325038 | Antimicrobial activity against Candida albicans P5 after 48 hrs by broth macrodilution method | 2007 | Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5 | A Candida albicans petite mutant strain with uncoupled oxidative phosphorylation overexpresses MDR1 and has diminished susceptibility to fluconazole and voriconazole. |
| AID619411 | Antifungal activity against Aspergillus niger assessed as inhibition of mycelial growth at 4 mg/ml after 7 days | 2011 | European journal of medicinal chemistry, Oct, Volume: 46, Issue:10 | Synthesis and biological evaluation of dihydroindeno and indeno [1,2-e] [1,2,4]triazolo [3,4-b] [1,3,4]thiadiazines as antimicrobial agents. |
| AID1904290 | Inhibition of Cryptococcus neoformans H99 delta5,6-desaturase assessed as upregulation of ERG11 gene expression at 2 ug/ml incubated for 24 hrs by RT-PCR analysis | 2022 | Journal of medicinal chemistry, 05-12, Volume: 65, Issue:9 | Discovery of Novel Sertraline Derivatives as Potent Anti- |
| AID687245 | Antifungal activity against Candida albicans ATCC 10231 after 2 days by microdilution broth method | 2012 | Bioorganic & medicinal chemistry letters, Oct-15, Volume: 22, Issue:20 | Synthesis and pharmacological evaluation of a novel series of 3-aryl-2-(2-substituted-4-methylthiazole-5-yl)thiazolidin-4-one as possible anti-inflammatory and antimicrobial agents. |
| AID1054565 | Antifungal activity against Aspergillus fumigatus after 48 hrs by broth microdilution technique | 2013 | European journal of medicinal chemistry, , Volume: 70 | Azole-carbodithioate hybrids as vaginal anti-Candida contraceptive agents: design, synthesis and docking studies. |
| AID1600170 | Antibacterial activity against Proteus mirabilis NCIM 2388 assessed as zone of inhibition at 80 ug/well incubated for 24 to 48 hrs by by agar well diffusion method | 2019 | European journal of medicinal chemistry, Oct-01, Volume: 179 | Synthesis of new thiazolyl-pyrazolyl-1,2,3-triazole derivatives as potential antimicrobial agents. |
| AID590505 | Antifungal activity against Candida albicans ATCC 10231 after 48 hrs | 2011 | European journal of medicinal chemistry, Apr, Volume: 46, Issue:4 | Synthesis, biopharmaceutical characterization, antimicrobial and antioxidant activities of 1-(4'-O-β-D-glucopyranosyloxy-2'-hydroxyphenyl)-3-aryl-propane-1,3-diones. |
| AID1254067 | Antibacterial activity against Staphylococcus aureus RN4220 after 24 hrs by two-fold serial dilution method | 2015 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 25, Issue:22 | Synthesis and biological evaluation of 1,3-diaryl pyrazole derivatives as potential antibacterial and anti-inflammatory agents. |
| AID518875 | Antimicrobial activity against Cryptococcus gattii serotype C isolate NIH298 assessed as heteroresistant isolates at 16 ug/ml | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Heteroresistance of Cryptococcus gattii to fluconazole. |
| AID425126 | Antimicrobial activity against azole-resistant Candida albicans isolate CA10 assessed as growth at 2 ug/ml cotreated with 0.002 ug/ml calcineurin signaling inhibitor tacrolimus after 48 hrs by microdilution checkerboard technique relative to control | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | In vitro interactions between tacrolimus and azoles against Candida albicans determined by different methods. |
| AID1487212 | Inhibition of CYP51 in Trichophyton rubrum assessed as inhibition of microbe growth incubated for 48 hrs by CLSI M27-A3 guideline based method | 2017 | Bioorganic & medicinal chemistry letters, 08-01, Volume: 27, Issue:15 | Design and optimization of highly-selective, broad spectrum fungal CYP51 inhibitors. |
| AID1069641 | Antimicrobial activity against Candida albicans after 24 hrs by broth microdilution method | 2014 | Bioorganic & medicinal chemistry letters, Feb-15, Volume: 24, Issue:4 | Synthesis and antimicrobial activities of novel 1,2,4-triazolo [3,4-a] phthalazine derivatives. |
| AID530948 | Antifungal activity against Candida tropicalis ATCC 750 at 163.3 uM after 48 hrs by CLSI method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Potent in vitro antifungal activities of naturally occurring acetylenic acids. |
| AID1549139 | Antifungal activity against azole-resistant Candida albicans 4108 after 48 hrs by spectrophotometry-based serial microdilution method | 2020 | Journal of medicinal chemistry, 05-28, Volume: 63, Issue:10 | Discovery of Novel Fungal Lanosterol 14α-Demethylase (CYP51)/Histone Deacetylase Dual Inhibitors to Treat Azole-Resistant Candidiasis. |
| AID214279 | Minimum inhibitory concentration of compound for antifungal activity against Trichophyton mentagrophytes | 2000 | Bioorganic & medicinal chemistry letters, Oct-02, Volume: 10, Issue:19 | Novel antifungals based on 4-substituted imidazole: a combinatorial chemistry approach to lead discovery and optimization. |
| AID1079943 | Malignant tumor, proven histopathologically. Value is number of references indexed. [column 'T.MAL' in source] | |||
| AID553853 | Antifungal activity against fluconazole sensitive Candida albicans isolate Gu4 in RPMI-1640 buffered medium after 24 hrs by microdilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | Enhanced susceptibility to antifungal oligopeptides in yeast strains overexpressing ABC multidrug efflux pumps. |
| AID518888 | Antimicrobial activity against Cryptococcus gattii serotype C isolate NIH113 assessed as heteroresistant isolates at 32 ug/ml | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Heteroresistance of Cryptococcus gattii to fluconazole. |
| AID444055 | Fraction absorbed in human | 2010 | Journal of medicinal chemistry, Feb-11, Volume: 53, Issue:3 | Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. |
| AID638560 | Antifungal activity against Aspergillus niger KCTC 1231 after 2 days by twofold broth dilution method | 2012 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 22, Issue:1 | Synthesis and antifungal activity of 6,7-bis(arylthio)-quinazoline-5,8-diones and furo[2,3-f]quinazolin-5-ols. |
| AID424892 | Antimicrobial activity against azole-resistant Candida albicans isolate CA10 assessed as growth at 2 ug/ml cotreated with 0.016 ug/ml calcineurin signaling inhibitor Tacrolimus after 48 hrs by microdilution checkboard technique relative to control | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | In vitro interactions between tacrolimus and azoles against Candida albicans determined by different methods. |
| AID1157291 | Antifungal activity against Candida albicans SC5314 assessed as growth inhibition by automatic microplate reader analysis | 2014 | Journal of natural products, May-23, Volume: 77, Issue:5 | Polyhydroxy cyclohexanols from a Dendrodochium sp. fungus associated with the sea cucumber Holothuria nobilis Selenka. |
| AID392363 | Antifungal activity against Candida glabrata 20/I after 24 hrs by broth microdilution method | 2009 | Bioorganic & medicinal chemistry letters, Jan-15, Volume: 19, Issue:2 | Salicylanilide esters of N-protected amino acids as novel antimicrobial agents. |
| AID462243 | Antifungal activity against Candida albicans SA40 infected in Wistar rat estrogen-dependent fungal vaginitis model assessed as fungal burden at 10 ug administered intravaginally 1 hr after fungal infection measured within 1 day of infection | 2010 | Journal of medicinal chemistry, Mar-25, Volume: 53, Issue:6 | Identification of inhibitors of drug-resistant Candida albicans strains from a library of bicyclic peptidomimetic compounds. |
| AID1864964 | Immunostimulatory activity in mouse infected with Candida albicans ATCC SC5314 assessed as increase in CD3+ expression level in spleen in presence of naproxen by immunohistochemical analysis | |||
| AID382541 | Antifungal activity against Saccharomyces cerevisiae SYM 3513 after 48 hrs standard broth microdilution method | 2008 | European journal of medicinal chemistry, Jan, Volume: 43, Issue:1 | Synthesis, structure and biological activity of pseudopeptidic macrolides based on an amino alcohol. |
| AID1864914 | Toxicity in Candida albicans ATCC SC5314 infected-mouse assessed as effect on body weight at 10 ug per 20 g, ip administered on day 2, 4, 6, 8, 10 and 12 and measured on day 14 in presence of naproxen | |||
| AID486964 | Antifungal activity against Cryptococcus neoformans after 72 hrs by micro broth dilution method | 2010 | European journal of medicinal chemistry, Jun, Volume: 45, Issue:6 | 'On water' assisted synthesis and biological evaluation of nitrogen and sulfur containing hetero-1,4-naphthoquinones as potent antifungal and antibacterial agents. |
| AID367167 | Cytotoxicity against human A431 cells at 0.001 mg/ml | 2009 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 19, Issue:3 | Synthesis and antifungal activity of 1,2,3-triazole containing fluconazole analogues. |
| AID678661 | Antifungal activity against Candida albicans ATCC 76615 by disc diffusion method | 2012 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 22, Issue:18 | Synthesis and biological evaluation of novel N-acyl substituted quinolin-2(1H)-one derivatives as potential antimicrobial agents. |
| AID518674 | Antimicrobial activity against Cryptococcus gattii serotype C isolate NIH113 assessed as heteroresistant isolates at 8 ug/ml | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Heteroresistance of Cryptococcus gattii to fluconazole. |
| AID1235432 | Antifungal activity against clinical isolates of Candida albicans 2367 by broth microdilution assay | 2015 | Bioorganic & medicinal chemistry, Aug-01, Volume: 23, Issue:15 | Imidazole clubbed 1,3,4-oxadiazole derivatives as potential antifungal agents. |
| AID1493827 | Antifungal activity against Candida albicans SC5314 after 24 hrs by spectrophotometric analysis | 2018 | European journal of medicinal chemistry, Jan-01, Volume: 143 | Discovery of simplified sampangine derivatives as novel fungal biofilm inhibitors. |
| AID285870 | Antimicrobial susceptibility of Pichia anomala from nosocomial fungemia patient assessed as percent susceptible isolates at 2 ug/ml by EUCAST method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Antifungal drug susceptibility profile of Pichia anomala isolates from patients presenting with nosocomial fungemia. |
| AID584410 | Antifungal activity against -3 days cultured Candida tropicalis isolated from neutropenic subject with AML or MDS pharynx receiving antifungal therapy for 45 days after 24 days of prophylaxis by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Impact of antifungal prophylaxis on colonization and azole susceptibility of Candida species. |
| AID47896 | Minimum concentration required to inhibit the growth of Candida parapsilosis ATCC 90018 was determined | 2002 | Bioorganic & medicinal chemistry letters, Oct-07, Volume: 12, Issue:19 | Synthesis and evaluation of novel pyrrolidinyl sordaricin derivatives as antifungal agents. |
| AID1063953 | Antifungal activity against Candida albicans ATCC 44859 after 48 hrs by broth microdilution method | 2014 | Bioorganic & medicinal chemistry, Jan-15, Volume: 22, Issue:2 | Salicylanilide diethyl phosphates: synthesis, antimicrobial activity and cytotoxicity. |
| AID494612 | Antifungal activity against Aspergillus fumigatus Tsukuba after 2 days by broth-microdilution method | 2010 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 20, Issue:15 | Synthesis and evaluation of novel antifungal agents-quinoline and pyridine amide derivatives. |
| AID521984 | Antibacterial activity against Fluconazole resistant Candida albicans DSY3606 containing tac1delta/delta ERG11-1/ERG11-1 (TAC1-5) genotype infected in BALB/c mouse assessed as weight change administered intraperitoneally 1 hr post bacterial challenge meas | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Genetic dissection of azole resistance mechanisms in Candida albicans and their validation in a mouse model of disseminated infection. |
| AID441346 | Antifungal activity against Penicillium citrinum NCIM 768 | 2009 | European journal of medicinal chemistry, Dec, Volume: 44, Issue:12 | Synthesis of 6-aminomethyl derivatives of benzopyran-4-one with dual biological properties: anti-inflammatory-analgesic and antimicrobial. |
| AID1238336 | Inhibition of CYP2C9 (unknown origin) at 120 uM by luminescent readout-based method | 2015 | Bioorganic & medicinal chemistry letters, Aug-15, Volume: 25, Issue:16 | Phenoxymethyl 1,3-oxazoles and 1,2,4-oxadiazoles as potent and selective agonists of free fatty acid receptor 1 (GPR40). |
| AID1054559 | Antifungal activity against Candida albicans after 48 hrs by broth microdilution technique | 2013 | European journal of medicinal chemistry, , Volume: 70 | Azole-carbodithioate hybrids as vaginal anti-Candida contraceptive agents: design, synthesis and docking studies. |
| AID1427200 | Antifungal activity against Candida albicans ATCC 44859 after 24 hrs by microdilution broth assay | 2017 | Bioorganic & medicinal chemistry, 03-15, Volume: 25, Issue:6 | Antimicrobial activity of rhodanine-3-acetic acid derivatives. |
| AID1651349 | Antifungal activity against fluconazole-resistant Candida albicans isolate 103 by NCCLS protocol based broth microdilution method | 2020 | Bioorganic & medicinal chemistry letters, 02-15, Volume: 30, Issue:4 | Design, synthesis, and structure-activity relationship studies of novel triazole agents with strong antifungal activity against Aspergillus fumigatus. |
| AID625769 | Antifungal activity against Candida albicans Y0109 after 24 hrs by serial dilution method | 2011 | European journal of medicinal chemistry, Nov, Volume: 46, Issue:11 | Design and synthesis of novel triazole antifungal derivatives by structure-based bioisosterism. |
| AID532535 | Antifungal activity against Saccharomyces cerevisiae BY4741 harboring human CYP51 assessed as accumulation of lanosterol at 16 ug/ml (Rvb = 23+/- 1.08 %) | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | Differential azole antifungal efficacies contrasted using a Saccharomyces cerevisiae strain humanized for sterol 14 alpha-demethylase at the homologous locus. |
| AID1239969 | Antifungal activity against Saccharomyces cerevisiae ATCC 9763 after 24 hrs by microbroth dilution method | 2015 | Bioorganic & medicinal chemistry letters, Sep-01, Volume: 25, Issue:17 | Design and biological evaluation of novel quinolone-based metronidazole derivatives as potent Cu(2+) mediated DNA-targeting antibacterial agents. |
| AID1287612 | Antifungal activity against Cryptococcus neoformans clinical isolate after 18 to 24 hrs by micro-dilution method | 2016 | European journal of medicinal chemistry, May-04, Volume: 113 | Synthesis of newer 1,2,3-triazole linked chalcone and flavone hybrid compounds and evaluation of their antimicrobial and cytotoxic activities. |
| AID405025 | Antifungal activity against Sporothrix schenckii P14954 isolate from cutaneous-lymphatic sporotrichosis patient after 72 hrs by Sensititre YeastOne method | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | In vitro susceptibility of Sporothrix schenckii to six antifungal agents determined using three different methods. |
| AID1738705 | Antifungal activity against clinical isolate Candida glabrata measured after 24 hrs by micro-broth dilution assay | 2020 | European journal of medicinal chemistry, Jul-15, Volume: 198 | Design, synthesis, and biological evaluation of novel miconazole analogues containing selenium as potent antifungal agents. |
| AID1783810 | Inhibition of Candida albicans CYP51 assessed as ergosterol level at 0.25 ug/ml measured after 18 hrs by GC-MS analysis relative to control | 2021 | European journal of medicinal chemistry, Nov-15, Volume: 224 | Improving the metabolic stability of antifungal compounds based on a scaffold hopping strategy: Design, synthesis, and structure-activity relationship studies of dihydrooxazole derivatives. |
| AID527131 | Antifungal activity against Microsporum gypseum LMGO 10 after 5 days microdilution technique | 2010 | Journal of natural products, Oct-22, Volume: 73, Issue:10 | Search for antifungal compounds from the wood of durable tropical trees. |
| AID1238923 | Antifungal activity against Candida parapsilosis ATCC 90018 WTBF-88 by microbroth dilution method | 2015 | Bioorganic & medicinal chemistry, Sep-01, Volume: 23, Issue:17 | Synthesis and antifungal evaluation of head-to-head and head-to-tail bisamidine compounds. |
| AID1890276 | Antifungal activity against Mucor circinelloides M5 strain assessed as reduction in fungal growth by broth dilution method | 2022 | Bioorganic & medicinal chemistry letters, 05-01, Volume: 63 | Novel 2-aryl-4-aryloxyquinoline-based fungistatics for Mucor circinelloides. Biological evaluation of activity, QSAR and docking study. |
| AID1885998 | Antifungal activity against Cryptococcus neoformans clinical isolate 443 assessed as fungal growth inhibition incubated for 72 hrs in presence of P163-0892 by broth microdilution method | |||
| AID1506725 | Antibacterial activity against Pseudomonas aeruginosa MTCC 741 by agar dilution method | 2017 | MedChemComm, Mar-01, Volume: 8, Issue:3 | Design, synthesis, molecular-docking and antimycobacterial evaluation of some novel 1,2,3-triazolyl xanthenones. |
| AID1624167 | Antifungal activity against Candida albicans NR-29434 after 24 hrs by microbroth dilution method | 2019 | Bioorganic & medicinal chemistry letters, 03-01, Volume: 29, Issue:5 | Benzimidazole tethered pyrrolo[3,4-b]quinoline with broad-spectrum activity against fungal pathogens. |
| AID582771 | Antifungal activity against Candida albicans isolate 12 harboring ERG3 W332R mutant gene assessed as ergosta 7,22-dienol content in total sterol composition at 0.5 times MIC by GC-MS analysis | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | Identification and characterization of four azole-resistant erg3 mutants of Candida albicans. |
| AID249257 | Antifungal activity to cause 99% reduction of surviving cells in 50% isolates | 2004 | Journal of medicinal chemistry, Jul-29, Volume: 47, Issue:16 | Imidazole analogues of fluoxetine, a novel class of anti-Candida agents. |
| AID1491340 | Antibacterial activity against Bacillus cereus UW 85 after 24 hrs by two-fold serial dilution method | 2017 | European journal of medicinal chemistry, Sep-08, Volume: 137 | Synthesis, antimicrobial, antiquorum-sensing and antitumor activities of new benzimidazole analogs. |
| AID1918339 | Antifungal activity against fluconazole-resistant Candida albicans 632 assessed as inhibition of fungal growth measured after 72 hrs by CLSI based liquid medium dilution method | 2022 | Journal of medicinal chemistry, 11-10, Volume: 65, Issue:21 | Novel Aryl Alkamidazole Derivatives as Multifunctional Antifungal Inhibitors: Design, Synthesis, and Biological Evaluation. |
| AID420666 | Antifungal activity against Microsporum gypseum by micro-broth dilution method | 2009 | European journal of medicinal chemistry, May, Volume: 44, Issue:5 | Design, synthesis, and biological evaluation of novel triazole derivatives as inhibitors of cytochrome P450 14alpha-demethylase. |
| AID561431 | Antifungal activity against Candida lusitaniae CL38 by microdilution method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Nonsense and missense mutations in FCY2 and FCY1 genes are responsible for flucytosine resistance and flucytosine-fluconazole cross-resistance in clinical isolates of Candida lusitaniae. |
| AID1168330 | Binding affinity to human serum albumin at 298 K by Scatchard method | 2014 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 24, Issue:21 | Study the interactions between human serum albumin and two antifungal drugs: fluconazole and its analogue DTP. |
| AID1254314 | Antifungal activity against Candida albicans ATCC 44859 after 24 hrs by microdilution broth method | 2015 | Bioorganic & medicinal chemistry, Nov-15, Volume: 23, Issue:22 | Novel derivatives of nitro-substituted salicylic acids: Synthesis, antimicrobial activity and cytotoxicity. |
| AID670736 | Antifungal activity against Candida albicans MTCC 3018 by spectrophotometry based assay | 2012 | Bioorganic & medicinal chemistry letters, Jul-15, Volume: 22, Issue:14 | Synthesis and evaluation of novel 3a,9a-dihydro-1-ethoxycarbonyl-1-cyclopenteno[5,4-b]benzopyran-4-ones as antifungal agents. |
| AID446449 | Antifungal activity against Candida albicans CA98001 | 2009 | Bioorganic & medicinal chemistry letters, Oct-15, Volume: 19, Issue:20 | Design of new antifungal agents: synthesis and evaluation of 1-[(1H-indol-5-ylmethyl)amino]-2-phenyl-3-(1H-1,2,4-triazol-1-yl)propan-2-ols. |
| AID1335843 | Antifungal activity against Candida albicans ATCC 76615 after 24 hrs by two fold serial dilution method | 2016 | European journal of medicinal chemistry, Nov-29, Volume: 124 | Multi-targeting exploration of new 2-aminothiazolyl quinolones: Synthesis, antimicrobial evaluation, interaction with DNA, combination with topoisomerase IV and penetrability into cells. |
| AID372252 | Fungicidal activity against wild type Candida albicans CAF2-1 assessed as reduction in cell viability at MIC of SSK21/CHK21 after 24 hrs | 2007 | Antimicrobial agents and chemotherapy, Oct, Volume: 51, Issue:10 | The Ssk1p response regulator and Chk1p histidine kinase mutants of Candida albicans are hypersensitive to fluconazole and voriconazole. |
| AID1762389 | Antifungal activity against Cryptococcus neoformans ATCC 208821 assessed as reduction in microbial growth after 36 hrs by resazurin dye based assay | 2021 | Bioorganic & medicinal chemistry, 05-15, Volume: 38 | Repurposing primaquine as a polyamine conjugate to become an antibiotic adjuvant. |
| AID1591917 | Antifungal activity against FLC-resistant Candida albicans assessed as inhibition of microbial growth incubated for 24 hrs by microbroth dilution assay relative to untreated control | 2019 | Journal of natural products, 08-23, Volume: 82, Issue:8 | Triterpenoids from |
| AID1465971 | Antifungal activity against Candida albicans ATCC 27365 after 44 hrs by broth dilution assay | 2017 | Bioorganic & medicinal chemistry, 06-01, Volume: 25, Issue:11 | Investigation of aryl isonitrile compounds with potent, broad-spectrum antifungal activity. |
| AID1196934 | Antifungal activity against Candida albicans SC5314 infected in BALB/c mouse assessed as reduction in reduction in fungal load in kidney at 10 mg/kg/day, ip for 5 days relative to vehicle-treated control | 2015 | Journal of medicinal chemistry, Feb-12, Volume: 58, Issue:3 | 2-(2-oxo-morpholin-3-yl)-acetamide derivatives as broad-spectrum antifungal agents. |
| AID1742131 | Antifungal activity against fluconazole-resistant Candida albicans 17# assessed as inhibition of microbial growth by two fold broth microdilution method | 2020 | European journal of medicinal chemistry, Nov-01, Volume: 205 | Design, synthesis and bioactivity evaluation of novel arylalkene-amide derivatives as dual-target antifungal inhibitors. |
| AID510311 | Antimicrobial activity against flucytosine, azole, and caspofungin resistant Candida glabrata bloodstream isolate 5 harboring FKS2 T1988C mutation and overexpressing CDR1 and CDR2 genes serially obtained from hematopoietic stem cell transplant recipient b | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Acquisition of flucytosine, azole, and caspofungin resistance in Candida glabrata bloodstream isolates serially obtained from a hematopoietic stem cell transplant recipient. |
| AID43431 | Compound was tested for the inhibition of beta-lactamase | 2003 | Journal of medicinal chemistry, Oct-09, Volume: 46, Issue:21 | Identification and prediction of promiscuous aggregating inhibitors among known drugs. |
| AID518412 | Antimicrobial activity against Cryptococcus gattii serotype B isolate RB3 assessed as heteroresistant isolates at 2 ug/ml | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Heteroresistance of Cryptococcus gattii to fluconazole. |
| AID1890271 | Antifungal activity against Microsporum canis clinical isolate 1 assessed as reduction in fungal growth by broth dilution method | 2022 | Bioorganic & medicinal chemistry letters, 05-01, Volume: 63 | Novel 2-aryl-4-aryloxyquinoline-based fungistatics for Mucor circinelloides. Biological evaluation of activity, QSAR and docking study. |
| AID1320771 | Antifungal activity against Aspergillus niger ATCC 16404 assessed as radial growth inhibition at 32 ug/ml after 5 to 7 days relative to control | 2016 | Bioorganic & medicinal chemistry, 11-15, Volume: 24, Issue:22 | Synthesis of novel tetrazole derivatives and evaluation of their antifungal activity. |
| AID1624184 | Antifungal activity against Candida albicans ATCC 10231 after 24 hrs by microbroth dilution method | 2019 | Bioorganic & medicinal chemistry letters, 03-01, Volume: 29, Issue:5 | Benzimidazole tethered pyrrolo[3,4-b]quinoline with broad-spectrum activity against fungal pathogens. |
| AID285863 | Antimicrobial susceptibility of Pichia anomala from nosocomial fungemia patient assessed as percent susceptible isolates at 0.015 ug/ml by EUCAST method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Antifungal drug susceptibility profile of Pichia anomala isolates from patients presenting with nosocomial fungemia. |
| AID642926 | Antifungal activity against Aspergillus niger ATCC 16404 at 160 ug/ml | 2011 | ACS medicinal chemistry letters, May-12, Volume: 2, Issue:5 | Natural Product Based 6-Hydroxy-2,3,4,6-tetrahydropyrrolo[1,2-a]pyrimidinium Scaffold as A New Antifungal Template. |
| AID750198 | Antifungal activity against Geotrichum species after 48 hrs by CLSI M27A3 broth microdilution method | 2013 | European journal of medicinal chemistry, Jun, Volume: 64 | Synthesis, antifungal and cytotoxic activities of 2-aryl-3-((piperidin-1-yl)ethyl)thiazolidinones. |
| AID117943 | In vivo evaluation of % survival rate after peroral administration on 3rd day at dose 0.5 mg/kg | 1995 | Journal of medicinal chemistry, Sep-29, Volume: 38, Issue:20 | Synthesis and antifungal activity of new azole derivatives containing an N-acylmorpholine ring. |
| AID554714 | Antimicrobial activity against Candida krusei NZCDC 89.102 after 48 hrs by CLSI method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Abc1p is a multidrug efflux transporter that tips the balance in favor of innate azole resistance in Candida krusei. |
| AID672346 | Antifungal activity against Aspergillus niger KCTC 1231 after 2 days | 2012 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 22, Issue:15 | Synthesis, antitubercular and antimicrobial evaluation of 3-(4-chlorophenyl)-4-substituted pyrazole derivatives. |
| AID545717 | Antifungal activity against Candida kefyr after 24 hrs by serial dilution method | 2010 | European journal of medicinal chemistry, Dec, Volume: 45, Issue:12 | Novel conformationally restricted triazole derivatives with potent antifungal activity. |
| AID1348083 | Antimicrobial activity against Candida parapsilosis ATCC 90018 assessed as zone of inhibition at 50 ug per disc after 48 hrs by disc diffusion assay | 2018 | European journal of medicinal chemistry, Jan-01, Volume: 143 | Synthesis of new 1-benzyl tetrahydropyridinylidene ammonium salts and their antimicrobial and anticellular activities. |
| AID1592230 | Inhibition of SE/CYP51 in Candida albicans ATCC SC5314 assessed as effect on sterol composition by measuring Lanosterol level at 16 ug/ml incubated for 90 mins by HPLC analysis (Rvb = 10.99%) | 2019 | Bioorganic & medicinal chemistry, 06-15, Volume: 27, Issue:12 | Design, synthesis and biological evaluation of amide-pyridine derivatives as novel dual-target (SE, CYP51) antifungal inhibitors. |
| AID584600 | Antifungal activity against 16 days cultured Candida krusei isolated from neutropenic subject with AML or MDS stool receiving antifungal therapy for 19 days after 6 days of prophylaxis by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Impact of antifungal prophylaxis on colonization and azole susceptibility of Candida species. |
| AID604066 | Antifungal activity against Candida parapsilosis MTCC 1744 after 18 hrs by microtiter broth dilution method | 2011 | European journal of medicinal chemistry, Jul, Volume: 46, Issue:7 | Total synthesis of racemic and (R) and (S)-4-methoxyalkanoic acids and their antifungal activity. |
| AID678725 | TP_TRANSPORTER: no influence on tissue distribution in mdr1a(-/-) mouse | 2002 | The Journal of pharmacology and experimental therapeutics, Oct, Volume: 303, Issue:1 | Interaction of cytochrome P450 3A inhibitors with P-glycoprotein. |
| AID704468 | Antifungal activity against Candida albicans MY 1055 after 24 hrs by NCCLS broth microdilution method | 2012 | ACS medicinal chemistry letters, Oct-11, Volume: 3, Issue:10 | Antifungal spectrum, in vivo efficacy, and structure-activity relationship of ilicicolin h. |
| AID424882 | Antimicrobial activity against azole-resistant Candida albicans isolate CA10 assessed as growth at 4 ug/ml co-treated with 0.031 ug/ml calcineurin signaling inhibitor tacrolimus after 48 hrs by microdilution checkboard technique relative to control | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | In vitro interactions between tacrolimus and azoles against Candida albicans determined by different methods. |
| AID1585627 | Antifungal activity against Candida albicans SC5314 cultured in YNB media after 48 hrs by broth microdilution method | 2019 | European journal of medicinal chemistry, Jan-15, Volume: 162 | Chemical preparation, biological evaluation and 3D-QSAR of ethoxysulfuron derivatives as novel antifungal agents targeting acetohydroxyacid synthase. |
| AID420662 | Antifungal activity against Candida parapsilosis by micro-broth dilution method | 2009 | European journal of medicinal chemistry, May, Volume: 44, Issue:5 | Design, synthesis, and biological evaluation of novel triazole derivatives as inhibitors of cytochrome P450 14alpha-demethylase. |
| AID584392 | Antifungal activity against 19 days cultured Candida glabrata isolated from HSCT recipient with acute or chronic GVHD mouth after 17 days of prophylaxis by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Impact of antifungal prophylaxis on colonization and azole susceptibility of Candida species. |
| AID405024 | Antifungal activity against Sporothrix schenckii P14954 isolate from cutaneous-lymphatic sporotrichosis patient after 72 hrs by modified NCCLS M38-A method | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | In vitro susceptibility of Sporothrix schenckii to six antifungal agents determined using three different methods. |
| AID1888272 | Antifungal activity against Candida albicans ATCC SC5314 assessed as decrease in ergosterol content at 4 ug/ml incubated for 48 hrs by LC-MS analysis (Rvb = 90.6%) | |||
| AID329034 | Antifungal activity against Candida parapsilosis ATCC 22019 after 24 hrs by serial agar dilution method | 2008 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 18, Issue:8 | Synthesis and antimicrobial properties of monensin A esters. |
| AID289666 | Antimicrobial activity against Candida albicans after 72 hrs by broth dilution assay | 2007 | Bioorganic & medicinal chemistry letters, Jan-15, Volume: 17, Issue:2 | N/C-4 substituted azetidin-2-ones: synthesis and preliminary evaluation as new class of antimicrobial agents. |
| AID319922 | Antifungal activity against Microsporum gypseum PTCC 5070 after 168 hrs by agar dilution method | 2008 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 18, Issue:1 | 2-Hydroxyphenacyl azoles and related azolium derivatives as antifungal agents. |
| AID1279025 | Antifungal activity against Candida krusei E28 after 24 hrs by microbroth dilution method | 2016 | Bioorganic & medicinal chemistry, Mar-15, Volume: 24, Issue:6 | Salicylanilide N-monosubstituted carbamates: Synthesis and in vitro antimicrobial activity. |
| AID554711 | Antimicrobial activity against Candida krusei B2399 after 48 hrs by CLSI method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Abc1p is a multidrug efflux transporter that tips the balance in favor of innate azole resistance in Candida krusei. |
| AID425123 | Antimicrobial activity against azole-resistant Candida albicans isolate CA10 assessed as growth at 0.25 ug/ml cotreated with 0.002 ug/ml calcineurin signaling inhibitor Tacrolimus after 48 hrs by microdilution checkboard technique relative to control | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | In vitro interactions between tacrolimus and azoles against Candida albicans determined by different methods. |
| AID1695848 | Antibacterial activity against Candida albicans MTCC 227 by serial dilution method | 2019 | European journal of medicinal chemistry, Apr-15, Volume: 168 | Comprehensive review on the anti-bacterial activity of 1,2,3-triazole hybrids. |
| AID1419554 | Selectivity index, ratio of EC50 for toxicity in human BEAS2B cells to MIC50 for antifungal activity against Candida glabrata ATCC 2001 | 2017 | European journal of medicinal chemistry, Jun-16, Volume: 133 | Novel alkylated azoles as potent antifungals. |
| AID1707526 | Antifungal activity against Candida albicans 0304103 infected in ICR mouse model of candidiasis assessed as reduction in kidney fungal burden at 1 mg/kg, ip dosed 24 hrs post infection and measured after 5 days | 2021 | Journal of medicinal chemistry, 01-28, Volume: 64, Issue:2 | Novel Carboline Fungal Histone Deacetylase (HDAC) Inhibitors for Combinational Treatment of Azole-Resistant Candidiasis. |
| AID1877314 | Cytotoxicity against human HEK293T cells assessed as inhibition of cell growth incubated for 4 hrs by MTT assay | 2022 | European journal of medicinal chemistry, Jan-05, Volume: 227 | Broadening antifungal spectrum and improving metabolic stablity based on a scaffold strategy: Design, synthesis, and evaluation of novel 4-phenyl-4,5-dihydrooxazole derivatives as potent fungistatic and fungicidal reagents. |
| AID419082 | Antifungal activity against Aspergillus fumigatus ATCC 26430 | 2009 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 19, Issue:7 | Amide analogs of antifungal dioxane-triazole derivatives: synthesis and in vitro activities. |
| AID555006 | Antifungal activity against Candida norvegensis assessed as dose dependent percent susceptible isolates at 25 ug/disc by CLSI M44-A disk diffusion method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | In vitro activities of fluconazole and voriconazole against clinical isolates of Candida spp. determined by disk diffusion testing in Turin, Italy. |
| AID555819 | Antifungal activity against cdr1/cdr1/cdr2/cdr2 deficient Candida albicans STY31 after 48 hrs | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Relative contributions of the Candida albicans ABC transporters Cdr1p and Cdr2p to clinical azole resistance. |
| AID781085 | Antifungal activity against Candida tropicalis MTCC-230 after 24 to 72 hrs by broth dilution method | 2013 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 23, Issue:22 | Unusual transformation of substituted-3-formylchromones to pyrimidine analogues: synthesis and antimicrobial activities of 5-(o-hydroxyaroyl)pyrimidines. |
| AID425131 | Antimicrobial activity against azole-resistant Candida albicans isolate CA10 assessed as growth at 64 ug/ml co-treated with 0.002 ug/ml calcineurin signaling inhibitor tacrolimus after 48 hrs by microdilution checkboard technique relative to control | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | In vitro interactions between tacrolimus and azoles against Candida albicans determined by different methods. |
| AID1689237 | Antifungal activity against Candida albicans SS5314 assessed as reduction in fungal growth measured after 10 passages by CLSI based broth microdilution method | 2020 | European journal of medicinal chemistry, Mar-01, Volume: 189 | Oxadiazolylthiazoles as novel and selective antifungal agents. |
| AID542096 | Antifungal activity against Aspergillus flavus ATCC 64025 after 24 hrs by microdilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Discovery of a small-molecule inhibitor of {beta}-1,6-glucan synthesis. |
| AID1867415 | Antifungal activity against fluconazole resistant Saccharomyces cerevisiae overexpressing CgCdr1p transporter assessed as reduction in fungal growth at lower concentration incubated for 48 hrs by serial dilution method | 2022 | Bioorganic & medicinal chemistry, 06-01, Volume: 63 | Effects of β-lapachone and β-nor-lapachone on multidrug efflux transporters and biofilms of Candida glabrata. |
| AID373525 | Antifungal activity against Candida krusei ATCC 6258 by macro-broth dilution method | 2009 | European journal of medicinal chemistry, May, Volume: 44, Issue:5 | Synthesis and antiparasitic and antifungal evaluation of 2'-arylsubstituted-1H,1'H-[2,5']bisbenzimidazolyl-5-carboxamidines. |
| AID285702 | Increase in growth of neonatal Wistar rat infected with Candida albicans ATCC 32354 and Staphylococcus epidermidis Hay assessed as weight gain at 10 mg/kg of body weight/day, ip for 4 days beginning 24 hrs before infection relative to control | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Neonatal coinfection model of coagulase-negative Staphylococcus (Staphylococcus epidermidis) and Candida albicans: fluconazole prophylaxis enhances survival and growth. |
| AID518687 | Antimicrobial activity against Cryptococcus gattii serotype B isolate NIH190 assessed as heteroresistant isolates at 16 ug/ml | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Heteroresistance of Cryptococcus gattii to fluconazole. |
| AID1157164 | Antifungal activity against Cryptococcus neoformans PMC 2136 after 72 hrs by CLSI broth microdilution method | 2014 | European journal of medicinal chemistry, Aug-18, Volume: 83 | Synthesis, biological evaluation and structure-activity correlation study of a series of imidazol-based compounds as Candida albicans inhibitors. |
| AID279087 | Antimicrobial activity against Candida glabrata at 24 hrs | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Association of fluconazole area under the concentration-time curve/MIC and dose/MIC ratios with mortality in nonneutropenic patients with candidemia. |
| AID572695 | Binding affinity to Mycobacterium smegmatis ATCC 700084 CYP164A2 at pH7.5 | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Identification, characterization, and azole-binding properties of Mycobacterium smegmatis CYP164A2, a homolog of ML2088, the sole cytochrome P450 gene of Mycobacterium leprae. |
| AID388085 | Antifungal activity at Fusarium oxysporum | 2008 | Bioorganic & medicinal chemistry letters, Oct-15, Volume: 18, Issue:20 | Synthesis of chimeric tetrapeptide-linked cholic acid derivatives: impending synergistic agents. |
| AID691708 | Antifungal activity against Candida albicans MTCC 3018 after 24 hrs by serial dilution method | 2012 | Bioorganic & medicinal chemistry letters, Oct-15, Volume: 22, Issue:20 | Synthesis of β-ionone derived chalcones as potent antimicrobial agents. |
| AID766645 | Antifungal activity against Candida albicans MTCC 4748 after 24 hrs by well diffusion method | 2013 | European journal of medicinal chemistry, Sep, Volume: 67 | Total synthesis and biological evaluation of clavaminol-G and its analogs. |
| AID1601660 | Antibiofilm activity against Candida albicans ATCC 10231 assessed as inhibition of mature biofilm formation by XTT reduction assay | |||
| AID1770943 | Antifungal activity against Candida krusei GIM2.1 assessed as fungal growth inhibition by CLSI protocol based method | 2021 | European journal of medicinal chemistry, Dec-05, Volume: 225 | Design, synthesis and evaluation of novel 5-phenylthiophene derivatives as potent fungicidal of Candida albicans and antifungal reagents of fluconazole-resistant fungi. |
| AID1898226 | Cytotoxicity against human Caco-2 cells assessed as cell viability at 64 ug/ml incubated for 24 hrs by CCK-8 assay | |||
| AID1546140 | Antifungal activity against Saccharomyces cerevisiae after 24 hrs | 2019 | European journal of medicinal chemistry, Dec-15, Volume: 184 | Current scenario of tetrazole hybrids for antibacterial activity. |
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| AID598229 | Antimicrobial activity against Candida tropicalis isolate 33 after 48 hrs by microdilution broth method | 2011 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 21, Issue:11 | Synthesis and in vitro antimicrobial activities of new (cyano-NNO-azoxy)pyrazole derivatives. |
| AID518149 | Antimicrobial activity against Cryptococcus gattii serotype B isolate B5765 assessed as concentration required for heteroresistance | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Heteroresistance of Cryptococcus gattii to fluconazole. |
| AID1287102 | Antimicrobial activity against Staphylococcus aureus ATCC 2592 assessed as inhibition of bacterial growth after 16 hrs by broth dilution method | 2016 | Journal of medicinal chemistry, Mar-10, Volume: 59, Issue:5 | A Designed Tryptophan- and Lysine/Arginine-Rich Antimicrobial Peptide with Therapeutic Potential for Clinical Antibiotic-Resistant Candida albicans Vaginitis. |
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| AID584376 | Ratio of ERG11 gene expression in Candida glabrata isolated from patient 497 receiving antifungal drug to ERG11 gene expression in Candida glabrata isolated from patient 497 by RT-PCR analysis | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Impact of antifungal prophylaxis on colonization and azole susceptibility of Candida species. |
| AID1598019 | Antifungal activity against Microsporum canis after 24 hrs by microbroth dilution method | 2019 | European journal of medicinal chemistry, May-15, Volume: 170 | Current advances of triazole alcohols derived from fluconazole: Design, in vitro and in silico studies. |
| AID582252 | Antifungal activity against Candida albicans isolated from neutropenic subjects with AML or MDS receiving fluconazole assessed as maximum MIC by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Impact of antifungal prophylaxis on colonization and azole susceptibility of Candida species. |
| AID594996 | Antifungal activity against Aspergillus fumigatus after 48 hrs by Halo zone test | 2011 | Bioorganic & medicinal chemistry letters, May-15, Volume: 21, Issue:10 | Thermal solvent-free synthesis of novel pyrazolyl chalcones and pyrazolines as potential antimicrobial agents. |
| AID1689836 | Inhibition of sterol biosynthesis in Candida albicans CAAL93 assessed as lanosterol level at 10 ng/ml after 18 hrs by GC-MS analysis (Rvb = 1.6%) | 2020 | European journal of medicinal chemistry, Mar-01, Volume: 189 | New azole antifungals with a fused triazinone scaffold. |
| AID1770946 | Antifungal activity against fluconazole-sensitive Candida albicans 632 assessed as fungal growth inhibition by CLSI protocol based method | 2021 | European journal of medicinal chemistry, Dec-05, Volume: 225 | Design, synthesis and evaluation of novel 5-phenylthiophene derivatives as potent fungicidal of Candida albicans and antifungal reagents of fluconazole-resistant fungi. |
| AID1205752 | Antifungal activity against Cryptococcus gattii LMM 818 after 72 hrs by microdilution method | 2015 | ACS medicinal chemistry letters, Mar-12, Volume: 6, Issue:3 | Synthesis of a New Peptide-Coumarin Conjugate: A Potential Agent against Cryptococcosis. |
| AID1742130 | Antifungal activity against Candida tropicalis assessed as inhibition of microbial growth by two fold broth microdilution method | 2020 | European journal of medicinal chemistry, Nov-01, Volume: 205 | Design, synthesis and bioactivity evaluation of novel arylalkene-amide derivatives as dual-target antifungal inhibitors. |
| AID1369488 | Antifungal activity against Candida albicans cgmcc 2.2086 in presence of 25% human heat-inactivated serum by broth dilution method | 2018 | Journal of medicinal chemistry, 05-10, Volume: 61, Issue:9 | Combating Drug-Resistant Fungi with Novel Imperfectly Amphipathic Palindromic Peptides. |
| AID1419525 | Effect on sterol composition in Candida albicans ATCC 10231 assessed as 14-alpha-methyl-ergosta-8,24(28)dien-3beta,6alpha-diol level at 0.125 ug/mL incubated for 10 mins by LC-MS analysis | 2017 | European journal of medicinal chemistry, Jun-16, Volume: 133 | Novel alkylated azoles as potent antifungals. |
| AID751631 | Antifungal activity against Candida albicans at 500 ppm | 2013 | European journal of medicinal chemistry, Feb, Volume: 60 | Synthesis and antifungal activity of some s-mercaptotriazolobenzothiazolyl amino acid derivatives. |
| AID1413330 | Antifungal activity against Candida albicans ATCC 10231 | 2018 | MedChemComm, Jun-01, Volume: 9, Issue:6 | Antifungal amphiphilic kanamycins: new life for an old drug. |
| AID561434 | Antifungal activity against Candida lusitaniae CL119 by microdilution method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Nonsense and missense mutations in FCY2 and FCY1 genes are responsible for flucytosine resistance and flucytosine-fluconazole cross-resistance in clinical isolates of Candida lusitaniae. |
| AID545272 | Antifungal activity against Candida glabrata 20/I after 24 hrs by broth microdilution method | 2010 | European journal of medicinal chemistry, Dec, Volume: 45, Issue:12 | New amino acid esters of salicylanilides active against MDR-TB and other microbes. |
| AID584591 | Antifungal activity against 176 days cultured Candida glabrata isolated from HSCT recipient with acute or chronic GVHD mouth receiving antifungal therapy for 168 days after 113 days of prophylaxis by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Impact of antifungal prophylaxis on colonization and azole susceptibility of Candida species. |
| AID717787 | Antimicrobial activity against Trichophyton mentagrophytes 445 after 72 hrs by broth microdilution test | 2012 | Bioorganic & medicinal chemistry, Dec-15, Volume: 20, Issue:24 | Contribution to investigation of antimicrobial activity of styrylquinolines. |
| AID1235435 | Antifungal activity against clinical isolates of Candida tropicalis 2356 by broth microdilution assay | 2015 | Bioorganic & medicinal chemistry, Aug-01, Volume: 23, Issue:15 | Imidazole clubbed 1,3,4-oxadiazole derivatives as potential antifungal agents. |
| AID1265814 | Antifungal activity against azole-resistant Candida albicans ATCC 10231 after 48 hrs by microbroth dilution method | 2015 | Journal of medicinal chemistry, Dec-10, Volume: 58, Issue:23 | Synthesis and Bioactivities of Kanamycin B-Derived Cationic Amphiphiles. |
| AID1758012 | Antifungal activity against fluconazole-resistant Candida albicans 901 assessed as inhibition of microbial growth after 24 hrs by broth microdilution method | 2021 | European journal of medicinal chemistry, Apr-15, Volume: 216 | Lead optimization generates selenium-containing miconazole CYP51 inhibitors with improved pharmacological profile for the treatment of fungal infections. |
| AID555822 | Ratio of MIC50 for Candida albicans 5674 to MIC50 for cdr2/cdr2 deficient Candida albicans STY7 | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Relative contributions of the Candida albicans ABC transporters Cdr1p and Cdr2p to clinical azole resistance. |
| AID594129 | Antifungal activity against Candida parapsilosis ATCC 90030 after 24 hrs | 2011 | European journal of medicinal chemistry, May, Volume: 46, Issue:5 | Pyridine-derived thiosemicarbazones and their tin(IV) complexes with antifungal activity against Candida spp. |
| AID619175 | Antifungal activity against Candida albicans CA21 by broth dilution method | 2011 | Journal of medicinal chemistry, Oct-13, Volume: 54, Issue:19 | High-throughput-screening-based identification and structure-activity relationship characterization defined (S)-2-(1-aminoisobutyl)-1-(3-chlorobenzyl)benzimidazole as a highly antimycotic agent nontoxic to cell lines. |
| AID1656498 | Antifungal activity against Candida glabrata assessed as fungal growth inhibition | 2020 | Bioorganic & medicinal chemistry letters, 02-01, Volume: 30, Issue:3 | Design, synthesis and bio-evaluation of C-1 alkylated tetrahydro-β-carboline derivatives as novel antifungal lead compounds. |
| AID407021 | Antimicrobial activity against Chk1 deficient Candida albicans CHK21 dissociated biofilms at cell density of 10'8 cells/ml after 48 hrs by XTT assay | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | Role for cell density in antifungal drug resistance in Candida albicans biofilms. |
| AID1415623 | Antifungal activity against fluconazole-resistant Candida tropicalis clinical isolate 087 assessed as fungal growth inhibition at 0.5 ug/ml after 48 hrs | 2017 | MedChemComm, May-01, Volume: 8, Issue:5 | Synthesis and synergistic antifungal effects of monoketone derivatives of curcumin against fluconazole-resistant |
| AID1557088 | Antifungal activity against Candida glabrata 192 assessed as reduction in fungal cell growth incubated for 48 hrs by MTT based broth double dilution method | 2019 | European journal of medicinal chemistry, Oct-01, Volume: 179 | Antifungal activity, mode of action variability, and subcellular distribution of coumarin-based antifungal azoles. |
| AID526734 | Antifungal activity against Candida krusei KCCM 11655 after 1 day | 2010 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 20, Issue:22 | Synthesis and antifungal activity of benzofuran-5-ols. |
| AID754919 | Antifungal activity against Trichosporon asahii 1188 assessed as growth inhibition after 24 to 48 hrs by microbroth dilution method | 2013 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 23, Issue:12 | Synthesis and antimycobacterial evaluation of N-substituted 5-chloropyrazine-2-carboxamides. |
| AID1770942 | Antifungal activity against Candida glabrata assessed as fungal growth inhibition by CLSI protocol based method | 2021 | European journal of medicinal chemistry, Dec-05, Volume: 225 | Design, synthesis and evaluation of novel 5-phenylthiophene derivatives as potent fungicidal of Candida albicans and antifungal reagents of fluconazole-resistant fungi. |
| AID766643 | Antifungal activity against Candida parapsilosis MTCC 1744 after 24 hrs by well diffusion method | 2013 | European journal of medicinal chemistry, Sep, Volume: 67 | Total synthesis and biological evaluation of clavaminol-G and its analogs. |
| AID279126 | Ratio of weight normalized daily dose in candidemia patient to MIC at 24 hrs against Candida albicans | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Association of fluconazole area under the concentration-time curve/MIC and dose/MIC ratios with mortality in nonneutropenic patients with candidemia. |
| AID737327 | Antimicrobial activity against Aspergillus niger MTCC 281 at 750 ug/ml after 72 hrs by cup plate method | 2013 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 23, Issue:7 | Synthesis of novel 2-amino-4-(5'-substituted 2'-phenyl-1H-indol-3'-yl)-6-aryl-4H-pyran-3-carbonitrile derivatives as antimicrobial and antioxidant agents. |
| AID1379753 | Antimicrobial activity against Candida albicans incubated for 48 hrs by serial dilution method | 2017 | European journal of medicinal chemistry, Nov-10, Volume: 140 | Synthesis, antimicrobial, antiquorum-sensing, antitumor and cytotoxic activities of new series of cyclopenta(hepta)[b]thiophene and fused cyclohepta[b]thiophene analogs. |
| AID525595 | Antibacterial activity against Fluconazole resistant Candida albicans DSY3606 containing tac1delta/delta ERG11-1/ERG11-1 (TAC1-5) genotype by EUCAST standards based broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Genetic dissection of azole resistance mechanisms in Candida albicans and their validation in a mouse model of disseminated infection. |
| AID432802 | Antifungal activity against Sporothrix mexicana after 72 hrs by microdilution method | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | In vitro antifungal susceptibilities of five species of sporothrix. |
| AID719319 | Antimicrobial activity against Staphylococcus aureus NCIM 5021 at 100 ug/mL incubated for 24 hrs by agar disc diffusion method | 2012 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 22, Issue:23 | Synthesis, characterization, antidepressant and antioxidant activity of novel piperamides bearing piperidine and piperazine analogues. |
| AID1179902 | Antimicrobial activity against Saccharomyces cerevisiae by two-fold serial dilution technique | 2014 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 24, Issue:15 | Synthesis and bioactive evaluation of a novel series of coumarinazoles. |
| AID1357633 | Antifungal activity against Candida parapsilosis ATCC 22019 after 48 hrs by microbroth dilution assay | 2018 | European journal of medicinal chemistry, May-10, Volume: 151 | Synthesis, molecular modeling studies and evaluation of antifungal activity of a novel series of thiazole derivatives. |
| AID1392825 | Inhibition of Cyp51 in Candida albicans ATCC SC5314 assessed as eburicol content at 0.03125 ug/ml after 16 hrs by GC-MS analysis (Rvb = 0.4%) | 2018 | Bioorganic & medicinal chemistry, 07-23, Volume: 26, Issue:12 | Design, synthesis and evaluation of benzoheterocycle analogues as potent antifungal agents targeting CYP51. |
| AID411181 | Ratio of MFC to MIC against Candida tropicalis DSM 1346 | 2009 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 19, Issue:1 | One-pot synthesis of 5-phenylimino, 5-thieno or 5-oxo-1,2,3-dithiazoles and evaluation of their antimicrobial and antitumor activity. |
| AID527135 | Antifungal activity against Trichophyton rubrum LMGO 4218 after 5 days microdilution technique | 2010 | Journal of natural products, Oct-22, Volume: 73, Issue:10 | Search for antifungal compounds from the wood of durable tropical trees. |
| AID446453 | Antifungal activity against fluconazole-resistant Candida krusei CK506 | 2009 | Bioorganic & medicinal chemistry letters, Oct-15, Volume: 19, Issue:20 | Design of new antifungal agents: synthesis and evaluation of 1-[(1H-indol-5-ylmethyl)amino]-2-phenyl-3-(1H-1,2,4-triazol-1-yl)propan-2-ols. |
| AID701455 | Antifungal activity against Cryptococcus neoformans | 2012 | Bioorganic & medicinal chemistry, Oct-01, Volume: 20, Issue:19 | The biology and chemistry of antifungal agents: a review. |
| AID741611 | Antifungal activity against Aspergillus flavus KCCM 11899 after 2 days by two fold broth dilution method | 2013 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 23, Issue:7 | Synthesis and antifungal evaluation of 7-arylamino-5,8-dioxo-5,8-dihydroisoquinoline-4-carboxylates. |
| AID1886035 | Synergistic antifungal activity against Candida krusei ATCC2340 assessed as fractional inhibitory concentration index incubated for 48 hrs in presence of P163-0892 by broth microdilution method | |||
| AID1428243 | Antibacterial activity against Pseudomonas aeruginosa measured after 18 hrs by agar dilution method | 2017 | European journal of medicinal chemistry, Jan-27, Volume: 126 | An insight on synthetic and medicinal aspects of pyrazolo[1,5-a]pyrimidine scaffold. |
| AID1634362 | Antifungal activity against fluconazole-resistant Candida albicans 100 assessed as inhibition of visible microbe growth by broth microdilution method | 2019 | Bioorganic & medicinal chemistry letters, 09-01, Volume: 29, Issue:17 | Design, synthesis and evaluation of biphenyl imidazole analogues as potent antifungal agents. |
| AID1904366 | Antifungal activity against FLC-resistant Candida albicans 901 assessed as fungal growth inhibition by CLSI based serial microbroth dilution method | 2022 | European journal of medicinal chemistry, Apr-05, Volume: 233 | Design, synthesis, and evaluation of novel 3-thiophene derivatives as potent fungistatic and fungicidal reagents based on a conformational restriction strategy. |
| AID420080 | Antifungal activity against Candida albicans CA-6 infected in CD1 mouse assessed as survival from fungus-induced mortality at 10 mg/kg, ip pretreated 2 hrs before fungus-challenge and once daily for 6 days | 2009 | Bioorganic & medicinal chemistry, Jun-01, Volume: 17, Issue:11 | Bulky 1,4-benzoxazine derivatives with antifungal activity. |
| AID453445 | Antifungal activity against Candida albicans ATCC 10231 after 48 hrs by broth microdilution method | 2010 | Bioorganic & medicinal chemistry letters, Jan-15, Volume: 20, Issue:2 | Fluconazole analogues containing 2H-1,4-benzothiazin-3(4H)-one or 2H-1,4-benzoxazin-3(4H)-one moieties, a novel class of anti-Candida agents. |
| AID29925 | Volume of distribution in man (IV dose) | 2002 | Journal of medicinal chemistry, Jun-20, Volume: 45, Issue:13 | Prediction of volume of distribution values in humans for neutral and basic drugs using physicochemical measurements and plasma protein binding data. |
| AID1287096 | Antimicrobial activity against antibiotic resistant Candida albicans clinical isolate 08032815 after 16 hrs by broth dilution method | 2016 | Journal of medicinal chemistry, Mar-10, Volume: 59, Issue:5 | A Designed Tryptophan- and Lysine/Arginine-Rich Antimicrobial Peptide with Therapeutic Potential for Clinical Antibiotic-Resistant Candida albicans Vaginitis. |
| AID1430407 | Antifungal activity against Candida krusei G03 after 24 to 48 hrs by macro-broth dilution method | 2017 | Bioorganic & medicinal chemistry letters, 03-01, Volume: 27, Issue:5 | Methylsulfonyl benzothiazoles (MSBT) derivatives: Search for new potential antimicrobial and anticancer agents. |
| AID319923 | Cytotoxicity against mouse NIH/3T3 cells after 72 hrs by MTT colorimetric assay | 2008 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 18, Issue:1 | 2-Hydroxyphenacyl azoles and related azolium derivatives as antifungal agents. |
| AID762710 | Antimicrobial activity against Aspergillus niger MTCC 281 at 50 ug/ml after 24 hrs by agar disc diffusion method | 2013 | Bioorganic & medicinal chemistry letters, Aug-15, Volume: 23, Issue:16 | Novel pyrazoline amidoxime and their 1,2,4-oxadiazole analogues: synthesis and pharmacological screening. |
| AID741616 | Antifungal activity against Candida krusei Berkout KCCM 11655 after 1 day by two fold broth dilution method | 2013 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 23, Issue:7 | Synthesis and antifungal evaluation of 7-arylamino-5,8-dioxo-5,8-dihydroisoquinoline-4-carboxylates. |
| AID1419546 | Selectivity index, ratio of EC50 for toxicity in human BEAS2B cells to MIC50 for antifungal activity against ITC and FLC-resistant Candida albicans ATCC MYA-90819 | 2017 | European journal of medicinal chemistry, Jun-16, Volume: 133 | Novel alkylated azoles as potent antifungals. |
| AID394716 | Antifungal activity against Cryptococcus neoformans H99 expressing PCTR4-2/FAS2 assessed as logarithmic reduction in viable cells at 8 ug/ml in presence of bathocuproinedisulfonic acid | 2007 | Antimicrobial agents and chemotherapy, Oct, Volume: 51, Issue:10 | Fatty acid synthesis is essential for survival of Cryptococcus neoformans and a potential fungicidal target. |
| AID457978 | Antifungal activity against Candida albicans ATCC 44859 after 48 hrs by microdilution method | 2010 | Bioorganic & medicinal chemistry, Mar-01, Volume: 18, Issue:5 | Antifungal 3,5-disubstituted furanones: From 5-acyloxymethyl to 5-alkylidene derivatives. |
| AID319750 | Antimicrobial activity against Candida albicans ATCC 76615 | 2008 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 18, Issue:11 | Synthesis and SAR studies of biaryloxy-substituted triazoles as antifungal agents. |
| AID1419535 | Hemolytic activity in mouse erythrocytes assessed as hemolysis level at 15.6 ug/ml incubated for 1 hr at 37 degC | 2017 | European journal of medicinal chemistry, Jun-16, Volume: 133 | Novel alkylated azoles as potent antifungals. |
| AID1491265 | Inhibition of CYP51 in Candida albicans ATCC SC5314 assessed as eburicol content at 0.03125 ug/ml by GS-MS analysis relative to total sterols (Rvb = 0.4%) | 2017 | European journal of medicinal chemistry, Sep-08, Volume: 137 | Design, synthesis and evaluation of aromatic heterocyclic derivatives as potent antifungal agents. |
| AID371226 | Antimicrobial activity against Candida albicans ATCC 24433 by broth microdilution method | 2008 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 18, Issue:24 | Carbon analogs of antifungal dioxane-triazole derivatives: synthesis and in vitro activities. |
| AID405046 | Antifungal activity against Sporothrix schenckii SSA29 isolate from cutaneous-lymphatic sporotrichosis patient after 72 hrs by Sensititre YeastOne method | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | In vitro susceptibility of Sporothrix schenckii to six antifungal agents determined using three different methods. |
| AID1494187 | Antifungal activity against Candida glabrata isolate CG2 measured after 48 hrs by CLSI M27-A3 protocol based method | 2018 | Bioorganic & medicinal chemistry, 02-01, Volume: 26, Issue:3 | Novel fluconazole derivatives with promising antifungal activity. |
| AID551208 | Antifungal activity against Candida tropicalis by broth microdilution method | 2011 | Bioorganic & medicinal chemistry letters, Jan-15, Volume: 21, Issue:2 | New azoles with antifungal activity: Design, synthesis, and molecular docking. |
| AID1783065 | Antifungal activity against fluconazole-sensitive Candida albicans SC5314 assessed as inhibition of fungal growth | 2021 | European journal of medicinal chemistry, Oct-05, Volume: 221 | Lanosterol 14α-demethylase (CYP51)/histone deacetylase (HDAC) dual inhibitors for treatment of Candida tropicalis and Cryptococcus neoformans infections. |
| AID457983 | Antifungal activity against Candida krusei ATCC 6258 after 24 hrs by microdilution method | 2010 | Bioorganic & medicinal chemistry, Mar-01, Volume: 18, Issue:5 | Antifungal 3,5-disubstituted furanones: From 5-acyloxymethyl to 5-alkylidene derivatives. |
| AID655723 | Antifungal activity against Aspergillus flavus MTCC 1021 after 48 hrs by poison food method MTCC 1021 | 2012 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 22, Issue:8 | Design, synthesis, synergistic antimicrobial activity and cytotoxicity of 4-aryl substituted 3,4-dihydropyrimidinones of curcumin. |
| AID1759435 | Antifungal activity against Cryptococcus neoformans PFCC 93-589 after 7 days in absence of sorbitol by microdilution assay | 2021 | Bioorganic & medicinal chemistry letters, 06-01, Volume: 41 | Inhibitory effects and mechanism of antifungal action of the natural cyclic depsipeptide, aureobasidin A against Cryptococcus neoformans. |
| AID425152 | Antimicrobial activity against azole-resistant Candida albicans isolate CA10 assessed as growth at 0.004 ug/ml after 48 hrs by microdilution checkerboard technique relative to control | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | In vitro interactions between tacrolimus and azoles against Candida albicans determined by different methods. |
| AID1157170 | Antifungal activity against Cryptococcus neoformans PMC 2111 after 72 hrs by CLSI broth microdilution method | 2014 | European journal of medicinal chemistry, Aug-18, Volume: 83 | Synthesis, biological evaluation and structure-activity correlation study of a series of imidazol-based compounds as Candida albicans inhibitors. |
| AID1572484 | Antifungal activity against Cryptococcus neoformans var. grubii ATCC 34877 after 48 hrs by serial dilution method | 2019 | Bioorganic & medicinal chemistry, 03-01, Volume: 27, Issue:5 | Discovery of novel simplified isoxazole derivatives of sampangine as potent anti-cryptococcal agents. |
| AID493522 | Antifungal activity against Aspergillus fumigatus 231 after 48 hrs by broth microdilution assay | 2010 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 20, Issue:15 | N-Benzylsalicylthioamides as novel compounds with promising antimycotic activity. |
| AID55046 | Minimum concentration required to inhibit the growth of Cryptococcus neoformans TIMM1855 was determined | 2002 | Bioorganic & medicinal chemistry letters, Oct-07, Volume: 12, Issue:19 | Synthesis and evaluation of novel pyrrolidinyl sordaricin derivatives as antifungal agents. |
| AID1272749 | Antifungal activity against Aspergillus niger at 0.03 mol/L after 2 to 4 days by paper disc method | 2016 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 26, Issue:3 | Synthesis, antimicrobial activity of Schiff base compounds of cinnamaldehyde and amino acids. |
| AID405045 | Antifungal activity against Sporothrix schenckii SSA29 isolate from cutaneous-lymphatic sporotrichosis patient after 72 hrs by modified NCCLS M38-A method | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | In vitro susceptibility of Sporothrix schenckii to six antifungal agents determined using three different methods. |
| AID535617 | Antifungal activity against Candida tropicalis T7 blood stream isolate | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | Caspofungin-resistant Candida tropicalis strains causing breakthrough fungemia in patients at high risk for hematologic malignancies. |
| AID655706 | Antifungal activity against Aspergillus niger MTCC 1108 at 160 uM/ml after 48 hrs by paper disc diffusion method | 2012 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 22, Issue:8 | Design, synthesis, synergistic antimicrobial activity and cytotoxicity of 4-aryl substituted 3,4-dihydropyrimidinones of curcumin. |
| AID304967 | Antibacterial activity against Streptococcus faecalis by broth micro-dilution technique | 2007 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 17, Issue:1 | New antifungal flavonoid glycoside from Vitex negundo. |
| AID1352427 | Antifungal activity against drug-resistant Candida albicans by CLSI two fold serial dilution method | 2018 | European journal of medicinal chemistry, Feb-25, Volume: 146 | Discovery of 2-aminothiazolyl berberine derivatives as effectively antibacterial agents toward clinically drug-resistant Gram-negative Acinetobacter baumanii. |
| AID1864926 | Toxicity in mouse infected with Candida albicans assessed as ALT level in plasma at 10 ug per 20 g, ip administered on day 2, 4, 6, 8, 10 and 12 and measured on day 14 in presence of naproxen (Rvb = 43.6 +/- 4.4 IU/L) | |||
| AID398058 | Antifungal activity against Saccharomyces cerevisiae DSY 416 expressing Candida albicans MDR1 after 40 to 48 hrs by serial dilution method | 2003 | Journal of natural products, Dec, Volume: 66, Issue:12 | Reversal of fluconazole resistance in multidrug efflux-resistant fungi by the Dysidea arenaria sponge sterol 9alpha,11alpha-epoxycholest-7-ene-3beta,5alpha,6alpha,19-tetrol 6-acetate. |
| AID1198410 | Fungicidal activity against Candida albicans ATCC 90028 incubated at 37 degC for 48 hrs by broth dilution method | 2015 | European journal of medicinal chemistry, Mar-26, Volume: 93 | Synthesis, QSAR and anticandidal evaluation of 1,2,3-triazoles derived from naturally bioactive scaffolds. |
| AID1597996 | Antifungal activity against Candida albicans after 24 hrs by NCCLS protocol based method | 2019 | European journal of medicinal chemistry, May-15, Volume: 170 | Current advances of triazole alcohols derived from fluconazole: Design, in vitro and in silico studies. |
| AID1886085 | Antifungal activity against Cryptococcus neoformans H99 infected in Wax moth larvae assessed as median survival time at 10 mg/kg measured after 9 days by Kaplan-Meier method | |||
| AID519674 | Antimicrobial activity against wild type Saccharomyces cerevisiae BY4741 by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Genomewide screening for genes associated with gliotoxin resistance and sensitivity in Saccharomyces cerevisiae. |
| AID531242 | Antifungal activity against Candida tropicalis assessed as susceptible isolates after 48 hrs by CLSI method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | In vitro susceptibilities of invasive isolates of Candida species: rapid increase in rates of fluconazole susceptible-dose dependent Candida glabrata isolates. |
| AID341410 | Antimicrobial activity against Cryptococcus neoformans USC1597 isolate after 72 hrs | 2007 | Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8 | New guinea pig model of Cryptococcal meningitis. |
| AID632571 | Antifungal activity against Aspergillus niger NCIM 1196 by agar diffusion method | 2011 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 21, Issue:24 | Molecular properties prediction and synthesis of novel 1,3,4-oxadiazole analogues as potent antimicrobial and antitubercular agents. |
| AID1246670 | Antifungal activity against Cryptococcus neoformans ATCC 24067 assessed as reduction in cell viability at 26 uM after 6 to 72 hrs by MTT assay | 2015 | European journal of medicinal chemistry, Sep-18, Volume: 102 | Thiazole compounds with activity against Cryptococcus gattii and Cryptococcus neoformans in vitro. |
| AID304969 | Antibacterial activity against Escherichia coli by broth micro-dilution technique | 2007 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 17, Issue:1 | New antifungal flavonoid glycoside from Vitex negundo. |
| AID45330 | Evaluation of In vitro antifungal activity against Candida albicans C56 by broth macro dilution method | 1995 | Journal of medicinal chemistry, Sep-29, Volume: 38, Issue:20 | Synthesis and antifungal activity of new azole derivatives containing an N-acylmorpholine ring. |
| AID1516959 | Antifungal activity against Candida albicans ATCC 44859 after 24 to 48 hrs | 2019 | Bioorganic & medicinal chemistry letters, 10-01, Volume: 29, Issue:19 | Recent advances in natural antifungal flavonoids and their derivatives. |
| AID1604178 | Antileishmanial activity against Leishmania amazonensis promastigotes assessed as reduction in parasite viability after 72 hrs by CCK-8 assay | 2019 | European journal of medicinal chemistry, Dec-01, Volume: 183 | Multi-target drugs active against leishmaniasis: A paradigm of drug repurposing. |
| AID369389 | Antimicrobial activity against Trichosporon isolate | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | In vitro susceptibility to posaconazole of 1,903 yeast isolates recovered in France from 2003 to 2006 and tested by the method of the European committee on antimicrobial susceptibility testing. |
| AID565556 | Antifungal activity against Rhizopus microsporus UTHSC 01-983 by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Correlation of in vitro activity, serum levels, and in vivo efficacy of posaconazole against Rhizopus microsporus in a murine disseminated infection. |
| AID1726243 | Antifungal activity against Candida duobushaemulonis CBS 7799 by CLSI standard M27 broth microdilution method | |||
| AID554998 | Antifungal activity against Candida tropicalis assessed as percent resistant isolates at 25 ug/disc by CLSI M44-A disk diffusion method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | In vitro activities of fluconazole and voriconazole against clinical isolates of Candida spp. determined by disk diffusion testing in Turin, Italy. |
| AID1079931 | Moderate liver toxicity, defined via clinical-chemistry results: ALT or AST serum activity 6 times the normal upper limit (N) or alkaline phosphatase serum activity of 1.7 N. Value is number of references indexed. [column 'BIOL' in source] | |||
| AID1359816 | Antifungal activity against Aspergillus fumigatus GIMCC 3.19 measured after 24 hrs | |||
| AID1413331 | Antifungal activity against resistant Candida albicans ATCC 64124 | 2018 | MedChemComm, Jun-01, Volume: 9, Issue:6 | Antifungal amphiphilic kanamycins: new life for an old drug. |
| AID528081 | Antifungal activity against Aspergillus niger by broth microdilution method | 2010 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 20, Issue:22 | Stereocontrolled facile synthesis and antimicrobial activity of oximes and oxime ethers of diversely substituted bispidines. |
| AID1918372 | Antifungal activity against Candida albicans infected in mouse assessed as reduction in fungal proliferation in the infection region at 20 mg/kg, ip administered on days 2,4,6,8,10,12 and measured on day 14 by hematoxylin-eosin staining based analysis | 2022 | Journal of medicinal chemistry, 11-10, Volume: 65, Issue:21 | Novel Aryl Alkamidazole Derivatives as Multifunctional Antifungal Inhibitors: Design, Synthesis, and Biological Evaluation. |
| AID1904382 | Disruption of membrane integrity in Candida albicans ATCC SC5314 assessed as rupture of fungal cells at 16 ug/ml incubated for 48 hrs by transmission electron microscopy | 2022 | European journal of medicinal chemistry, Apr-05, Volume: 233 | Design, synthesis, and evaluation of novel 3-thiophene derivatives as potent fungistatic and fungicidal reagents based on a conformational restriction strategy. |
| AID719306 | Antimicrobial activity against Candida albicans NCIM 3471 at 10 ug/disc incubated for 48 hrs by agar disc diffusion method | 2012 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 22, Issue:23 | Synthesis, characterization, antidepressant and antioxidant activity of novel piperamides bearing piperidine and piperazine analogues. |
| AID245429 | Minimum inhibitory concentration against Candida krusei ATCC 6528 evaluated by in vitro agar diffusion and micro-broth dilution assay | 2005 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 15, Issue:15 | Synthesis of some diguanidino 1-methyl-2,5-diaryl-1H-pyrroles as antifungal agents. |
| AID1247370 | Antifungal activity against Candida albicans Y0109 after 24 hrs by serial dilution method | 2015 | European journal of medicinal chemistry, Sep-18, Volume: 102 | Design, synthesis, and structure-activity relationship studies of novel thienopyrrolidone derivatives with strong antifungal activity against Aspergillus fumigates. |
| AID1361020 | Antifungal activity against Candida albicans MTCC 3958 after 48 hrs | 2018 | European journal of medicinal chemistry, Jul-15, Volume: 155 | Rational modification of a lead molecule: Improving the antifungal activity of indole - triazole - amino acid conjugates. |
| AID516270 | Antimicrobial activity against Cryptococcus gattii serotype B isolate B3939 assessed as concentration required for heteroresistance | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Heteroresistance of Cryptococcus gattii to fluconazole. |
| AID665068 | Antifungal activity against Candida tropicalis after 24 hrs by serial dilution method | 2012 | European journal of medicinal chemistry, Jul, Volume: 53 | Design, synthesis and structure-activity relationships of new triazole derivatives containing N-substituted phenoxypropylamino side chains. |
| AID625770 | Antifungal activity against Candida tropicalis 087 after 24 hrs by serial dilution method | 2011 | European journal of medicinal chemistry, Nov, Volume: 46, Issue:11 | Design and synthesis of novel triazole antifungal derivatives by structure-based bioisosterism. |
| AID1271234 | Antifungal activity against Candida albicans ATCC 24433 after 72 hrs by broth microdilution method | 2015 | ACS medicinal chemistry letters, Nov-12, Volume: 6, Issue:11 | Silicon Incorporated Morpholine Antifungals: Design, Synthesis, and Biological Evaluation. |
| AID1154833 | Inhibition of hyphal growth of fluconazole-sensitive Candida albicans SC5314 at 8 ug/ml after 16 hrs by light microscopic analysis | 2014 | ACS medicinal chemistry letters, May-08, Volume: 5, Issue:5 | Novel carboline derivatives as potent antifungal lead compounds: design, synthesis, and biological evaluation. |
| AID1689837 | Inhibition of sterol biosynthesis in Candida albicans CAAL93 assessed as eburicol level at 10 ng/ml after 18 hrs by GC-MS analysis relative to control | 2020 | European journal of medicinal chemistry, Mar-01, Volume: 189 | New azole antifungals with a fused triazinone scaffold. |
| AID424920 | Antimicrobial activity against azole-resistant Candida albicans isolate CA10 assessed as growth at 128 ug/ml cotreated with 0.004 ug/ml calcineurin signaling inhibitor Tacrolimus after 48 hrs by microdilution checkboard technique relative to control | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | In vitro interactions between tacrolimus and azoles against Candida albicans determined by different methods. |
| AID626346 | Antifungal activity against Candida albicans MTCC 3017 at 0.5 mg/mL after 72 hrs by by agar-well diffusion method | 2011 | European journal of medicinal chemistry, Nov, Volume: 46, Issue:11 | Hantzsch reaction: synthesis and characterization of some new 1,4-dihydropyridine derivatives as potent antimicrobial and antioxidant agents. |
| AID1852891 | Antifungal activity against Candida albicans SC5314 assessed as inhibition of fungal growth incubated for 24 hrs by microdilution assay | 2022 | RSC medicinal chemistry, Nov-16, Volume: 13, Issue:11 | Efficient selective targeting of |
| AID1348790 | Antifungal activity against Candida albicans patient isolate after 48 hrs by broth microdilution method | 2018 | European journal of medicinal chemistry, Jan-01, Volume: 143 | Substituted carbamothioic amine-1-carbothioic thioanhydrides as novel trichomonicidal fungicides: Design, synthesis, and biology. |
| AID269977 | Antifungal activity against Candida albicans 607 | 2006 | Journal of medicinal chemistry, Aug-10, Volume: 49, Issue:16 | Synthesis and antifungal activity of a novel series of alkyldimethylamine cyanoboranes and their derivatives. |
| AID1888269 | Induction of apoptosis in Candida albicans ATCC SC5314 cells assessed as early apoptotic cells at 8 ug/ml incubated for 72 hrs by Annexin V-FITC/PI staining based flow cytometry method (Rvb = 0.56%) | |||
| AID1418536 | Cytotoxicity against human HT-29 cells by MTT assay | 2018 | Bioorganic & medicinal chemistry letters, 12-01, Volume: 28, Issue:22 | Design, synthesis, and biological evaluation of 4-chloro-2H-thiochromenes featuring nitrogen-containing side chains as potent antifungal agents. |
| AID1154823 | Fungicidal activity against fluconazole-sensitive Candida albicans SC5314 assessed as reduction in fungi density after 24 hrs | 2014 | ACS medicinal chemistry letters, May-08, Volume: 5, Issue:5 | Novel carboline derivatives as potent antifungal lead compounds: design, synthesis, and biological evaluation. |
| AID1585637 | Antifungal activity against Saccharomyces cerevisiae SC XH1549 cultured in YNB media after 72 hrs by broth microdilution method | 2019 | European journal of medicinal chemistry, Jan-15, Volume: 162 | Chemical preparation, biological evaluation and 3D-QSAR of ethoxysulfuron derivatives as novel antifungal agents targeting acetohydroxyacid synthase. |
| AID1639191 | Binding affinity to Mycobacterium tuberculosis H37Rv CYP121A1 by UV-visible scanning spectrophotometric analysis | 2019 | Bioorganic & medicinal chemistry, 04-15, Volume: 27, Issue:8 | Synthesis and biological evaluation of novel cYY analogues targeting Mycobacterium tuberculosis CYP121A1. |
| AID1059364 | Antifungal activity against Candida parapsilosis after 20 hrs by agar dilution method | 2013 | European journal of medicinal chemistry, , Volume: 70 | Designing and synthesis of novel antimicrobial heterocyclic analogs of fatty acids. |
| AID1822729 | Antifungal activity against azole-resistant Candida albicans 030410 assessed as inhibition of fungal filamentation by measuring reduction in yeast-hypha transition at 32 ug/ml by microscopic analysis | 2022 | Journal of medicinal chemistry, 02-10, Volume: 65, Issue:3 | Structure-Guided Discovery of the Novel Covalent Allosteric Site and Covalent Inhibitors of Fructose-1,6-Bisphosphate Aldolase to Overcome the Azole Resistance of |
| AID1624175 | Antifungal activity against Candida albicans NR-29366 after 24 hrs by microbroth dilution method | 2019 | Bioorganic & medicinal chemistry letters, 03-01, Volume: 29, Issue:5 | Benzimidazole tethered pyrrolo[3,4-b]quinoline with broad-spectrum activity against fungal pathogens. |
| AID285852 | Antimicrobial susceptibility of Pichia anomala from nosocomial fungemia patient assessed as percent susceptible isolates at 0.015 ug/ml by CLSI method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Antifungal drug susceptibility profile of Pichia anomala isolates from patients presenting with nosocomial fungemia. |
| AID477336 | Antifungal activity against Candida krusei ATCC 6528 after 48 to 72 hrs by microdilution method | 2010 | European journal of medicinal chemistry, Apr, Volume: 45, Issue:4 | Synthesis and characterization of novel fatty acid analogs of cholesterol: in vitro antimicrobial activity. |
| AID532550 | Antifungal activity against Saccharomyces cerevisiae BY4741 harboring human CYP51 by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | Differential azole antifungal efficacies contrasted using a Saccharomyces cerevisiae strain humanized for sterol 14 alpha-demethylase at the homologous locus. |
| AID454198 | Antifungal activity against Aspergillus niger NCIM 1196 by standard agar plate method | 2010 | Bioorganic & medicinal chemistry letters, Jan-15, Volume: 20, Issue:2 | One pot synthesis and SAR of some novel 3-substituted 5,6-diphenyl-1,2,4-triazines as antifungal agents. |
| AID1491261 | Inhibition of CYP51 in Candida albicans ATCC SC5314 assessed as lanosterol content at 0.125 ug/ml by GS-MS analysis relative to total sterols | 2017 | European journal of medicinal chemistry, Sep-08, Volume: 137 | Design, synthesis and evaluation of aromatic heterocyclic derivatives as potent antifungal agents. |
| AID1886002 | Antifungal activity against Cryptococcus gattii clinical isolate SCZ20031 assessed as fungal growth inhibition incubated for 72 hrs in presence of P163-0892 by broth microdilution method | |||
| AID405014 | Antifungal activity against Sporothrix schenckii PSSA81 isolate from cutaneous-lymphatic sporotrichosis patient after 72 hrs by ATB Fungus 2 method | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | In vitro susceptibility of Sporothrix schenckii to six antifungal agents determined using three different methods. |
| AID405187 | Antimicrobial activity against Blastoschizomyces capitatus IHEM 16105 isolate infected OF1 mouse blastoschizomycosis model assessed as mean survival time at 80 mg/kg/day, po for 6 days administered 1 hr before microbial challenge | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | Combined therapies in a murine model of blastoschizomycosis. |
| AID619179 | Antifungal activity against Candida albicans AM2001/2007 by broth dilution method | 2011 | Journal of medicinal chemistry, Oct-13, Volume: 54, Issue:19 | High-throughput-screening-based identification and structure-activity relationship characterization defined (S)-2-(1-aminoisobutyl)-1-(3-chlorobenzyl)benzimidazole as a highly antimycotic agent nontoxic to cell lines. |
| AID424624 | Antimicrobial activity against azole-resistant Candida albicans isolate CA15 after 48 hrs by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | In vitro interactions between tacrolimus and azoles against Candida albicans determined by different methods. |
| AID647407 | Antifungal activity against Candida albicans ATCC 90028 after 24 to 48 hrs by serial broth microdilution susceptibility test | 2012 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 22, Issue:3 | Novel dendrimeric lipopeptides with antifungal activity. |
| AID308611 | Antifungal activity against Candida parapsilosis ATCC 22019 | 2007 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 17, Issue:15 | Antifungal activity in triterpene glycosides from the sea cucumber Actinopyga lecanora. |
| AID670735 | Antifungal activity against Saccharomyces cerevisiae MTCC 1344 by spectrophotometry based assay | 2012 | Bioorganic & medicinal chemistry letters, Jul-15, Volume: 22, Issue:14 | Synthesis and evaluation of novel 3a,9a-dihydro-1-ethoxycarbonyl-1-cyclopenteno[5,4-b]benzopyran-4-ones as antifungal agents. |
| AID521792 | Fungistatic activity against Candida glabrata isolate 4293 assessed as 99.9% reduction of initial fungal load at 0.5 times MIC after 48 hrs using colony count method by time-kill method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Posaconazole against Candida glabrata isolates with various susceptibilities to fluconazole. |
| AID1556210 | Antifungal activity against Cryptococcus neoformans CGMCC 2.3161 assessed as inhibition of visible microbial growth by NCCLS protocol based method | 2019 | European journal of medicinal chemistry, Sep-01, Volume: 177 | Design, synthesis, and structure-activity relationship studies of l-amino alcohol derivatives as broad-spectrum antifungal agents. |
| AID1168343 | Ratio of binding constant for human serum albumin in presence of Mg2+ to binding constant for human serum albumin in absence of metal ions | 2014 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 24, Issue:21 | Study the interactions between human serum albumin and two antifungal drugs: fluconazole and its analogue DTP. |
| AID1886030 | Synergistic antifungal activity against Cryptococcus gattii WM178 assessed as fractional inhibitory concentration index incubated for 72 hrs in presence of P163-0892 by broth microdilution method | |||
| AID642939 | Antifungal activity against fluconazole-resistant Candida albicans isolate 1 isolated from AIDS patient | 2011 | ACS medicinal chemistry letters, May-12, Volume: 2, Issue:5 | Natural Product Based 6-Hydroxy-2,3,4,6-tetrahydropyrrolo[1,2-a]pyrimidinium Scaffold as A New Antifungal Template. |
| AID1196910 | Half life in human plasma | 2015 | Journal of medicinal chemistry, Feb-12, Volume: 58, Issue:3 | 2-(2-oxo-morpholin-3-yl)-acetamide derivatives as broad-spectrum antifungal agents. |
| AID1312609 | Antifungal activity against naftifine-sensitive Trichophyton mentagrophytes after 7 days by serial dilution method | 2016 | Journal of medicinal chemistry, 05-26, Volume: 59, Issue:10 | Discovery of Benzocycloalkane Derivatives Efficiently Blocking Bacterial Virulence for the Treatment of Methicillin-Resistant S. aureus (MRSA) Infections by Targeting Diapophytoene Desaturase (CrtN). |
| AID1905260 | Antifungal activity against fluconazole-resistant Candida albicans 632 assessed as inhibition of fungal growth by checker board microdilution assay | 2022 | Journal of medicinal chemistry, 04-14, Volume: 65, Issue:7 | Species-Selective Targeting of Fungal Hsp90: Design, Synthesis, and Evaluation of Novel 4,5-Diarylisoxazole Derivatives for the Combination Treatment of Azole-Resistant Candidiasis. |
| AID405107 | Antimicrobial activity against Mucor sp. after assessed as percent of susceptible isolates after 24 hrs | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | In vitro susceptibilities of 217 clinical isolates of zygomycetes to conventional and new antifungal agents. |
| AID521979 | Antibacterial activity against Fluconazole resistant Candida albicans DSY3083 containing tac1delta/delta genotype containing CIp10 to restore URA3 function infected in BALB/c mouse assessed as reduction in kidney microbial burden administered intraperiton | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Genetic dissection of azole resistance mechanisms in Candida albicans and their validation in a mouse model of disseminated infection. |
| AID526813 | Antifungal activity against Saccharomyces cerevisiae YPH500 assessed as concentration required to 50% growth inhibition using alamar blue staining after 18 to 72 hrs by microdilution method | 2010 | Bioorganic & medicinal chemistry, Nov-01, Volume: 18, Issue:21 | 1,3-Benzoxazole-4-carbonitrile as a novel antifungal scaffold of β-1,6-glucan synthesis inhibitors. |
| AID519060 | Antifungal activity against Candida tropicalis assessed as susceptible isolates after 48 hrs by broth microdilution | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | Antimicrobial activity of omiganan pentahydrochloride against contemporary fungal pathogens responsible for catheter-associated infections. |
| AID1783090 | Downregulation of CDR1 mRNA expression in Candida tropicalis 5008 at 4 ug/ml measured after 24 hrs by qRT-PCR analysis | 2021 | European journal of medicinal chemistry, Oct-05, Volume: 221 | Lanosterol 14α-demethylase (CYP51)/histone deacetylase (HDAC) dual inhibitors for treatment of Candida tropicalis and Cryptococcus neoformans infections. |
| AID405063 | Antifungal activity against Sporothrix schenckii P3287 isolate from cutaneous-lymphatic sporotrichosis patient after 72 hrs by modified NCCLS M38-A method | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | In vitro susceptibility of Sporothrix schenckii to six antifungal agents determined using three different methods. |
| AID1820643 | Antifungal activity against fluconazole and itraconazole resistant Candida albicans 17# assessed as inhibition of fungal growth by NCCLS protocol based method | 2022 | European journal of medicinal chemistry, Jan-15, Volume: 228 | Design, synthesis, and biological activity evaluation of 2-(benzo[b]thiophen-2-yl)-4-phenyl-4,5-dihydrooxazole derivatives as broad-spectrum antifungal agents. |
| AID1762149 | Antifungal activity against Candida parapsilosis ATCC 22019 assessed as reduction in fungal growth incubated for 48 hrs by CLSI based serial microbroth dilution method | 2021 | Bioorganic & medicinal chemistry letters, 05-15, Volume: 40 | Synthesis and antifungal activity of new hybrids thiazolo[4,5-d]pyrimidines with (1H-1,2,4)triazole. |
| AID464675 | Antifungal activity against Aspergillus niger after 48 to 72 hrs by broth microdilution method | 2010 | European journal of medicinal chemistry, Mar, Volume: 45, Issue:3 | Synthesis and antimicrobial studies on novel sulfonamides containing 4-azidomethyl coumarin. |
| AID1877311 | Ratio of MIC for fungicidal activity against Candida albicans CPCC400616 to MFC for fungicidal activity against Candida albicans CPCC400616 | 2022 | European journal of medicinal chemistry, Jan-05, Volume: 227 | Broadening antifungal spectrum and improving metabolic stablity based on a scaffold strategy: Design, synthesis, and evaluation of novel 4-phenyl-4,5-dihydrooxazole derivatives as potent fungistatic and fungicidal reagents. |
| AID1886045 | Synergistic antifungal activity against Cryptococcus neoformans clinical isolate HN20 assessed as fractional inhibitory concentration index incubated for 72 hrs in presence of P163-0892 by broth microdilution method | |||
| AID1886084 | Antifungal activity against Cryptococcus neoformans H99 infected in Wax moth larvae assessed as reduction on fungal burden at 10 mg/kg measured after 9 days in presence of P163-0892 by 10 fold serial dilution method | |||
| AID519286 | Antifungal activity against Candida parapsilosis ATCC 22019 by WIDERYST method | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | Reliability of the WIDERYST susceptibility testing system for detection of in vitro antifungal resistance in yeasts. |
| AID582775 | Antifungal activity against Candida albicans isolate 488 harboring ERG3 H243N, T330A, A351V and ERG11 D225G, E266D, E391G, V488I mutant genes assessed as 14alpha-methyl fecosterol content in total sterol composition at 0.5 times MIC by GC-MS analysis | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | Identification and characterization of four azole-resistant erg3 mutants of Candida albicans. |
| AID144060 | Compound was evaluated for its inhibitory activity against human N-myristoyltransferase (HsNmt); Not tested | 2001 | Bioorganic & medicinal chemistry letters, Jul-23, Volume: 11, Issue:14 | Design and synthesis of novel benzofurans as a new class of antifungal agents targeting fungal N-myristoyltransferase. Part 1. |
| AID1221956 | Apparent permeability from apical to basolateral side of human Caco2 cells at 10 uM up to 120 mins by HPLC-MC analysis | 2011 | Drug metabolism and disposition: the biological fate of chemicals, Feb, Volume: 39, Issue:2 | Attenuation of intestinal absorption by major efflux transporters: quantitative tools and strategies using a Caco-2 model. |
| AID407057 | Antimicrobial activity against Candida albicans SC5314 dissociated biofilms grown on polyvinylchloride catheter surface at cell density of 10'3 cells/ml at 0.25 to 8 ug/ml by XTT assay | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | Role for cell density in antifungal drug resistance in Candida albicans biofilms. |
| AID293382 | Antifungal activity against Candida krusei ATCC 6258 by micro-broth dilution method | 2007 | European journal of medicinal chemistry, Aug, Volume: 42, Issue:8 | Synthesis and evaluation of novel 1-(1H-1,2,4-triazol-1-yl)-2-(2,4-difluorophenyl)-3-[(4-substitutedphenyl)-piperazin-1-yl]-propan-2-ols as antifungal agents. |
| AID518700 | Antimicrobial activity against Cryptococcus gattii serotype C isolate NIH34 assessed as heteroresistant isolates at 16 ug/ml | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Heteroresistance of Cryptococcus gattii to fluconazole. |
| AID1242645 | Antibacterial activity against Klebsiella pneumoniae ATCC 27736 after 16 hrs by microtiter broth dilution method | 2015 | ACS medicinal chemistry letters, Jul-09, Volume: 6, Issue:7 | Novel Chalcone-Thiazole Hybrids as Potent Inhibitors of Drug Resistant Staphylococcus aureus. |
| AID1379748 | Antimicrobial activity against Aspergillus fumigatus incubated for 48 hrs by disc diffusion assay | 2017 | European journal of medicinal chemistry, Nov-10, Volume: 140 | Synthesis, antimicrobial, antiquorum-sensing, antitumor and cytotoxic activities of new series of cyclopenta(hepta)[b]thiophene and fused cyclohepta[b]thiophene analogs. |
| AID262549 | Antifungal activity against Cryptococcus neoformans | 2006 | Journal of medicinal chemistry, Apr-20, Volume: 49, Issue:8 | Structure-based optimization of azole antifungal agents by CoMFA, CoMSIA, and molecular docking. |
| AID440311 | Anticandidal activity against Candida albicans 15T after 24 hrs by spectrophotometry | 2009 | Journal of medicinal chemistry, Dec-10, Volume: 52, Issue:23 | Synthesis of new linear guanidines and macrocyclic amidinourea derivatives endowed with high antifungal activity against Candida spp. and Aspergillus spp. |
| AID1624182 | Antifungal activity against Candida parapsilosis ATCC 22019 after 24 hrs by microbroth dilution method | 2019 | Bioorganic & medicinal chemistry letters, 03-01, Volume: 29, Issue:5 | Benzimidazole tethered pyrrolo[3,4-b]quinoline with broad-spectrum activity against fungal pathogens. |
| AID369381 | Antimicrobial activity against Candida utilis isolate | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | In vitro susceptibility to posaconazole of 1,903 yeast isolates recovered in France from 2003 to 2006 and tested by the method of the European committee on antimicrobial susceptibility testing. |
| AID372250 | Fungicidal activity against Candida albicans CHK21 assessed as reduction in cell viability at 4 times MIC after 24 hrs | 2007 | Antimicrobial agents and chemotherapy, Oct, Volume: 51, Issue:10 | The Ssk1p response regulator and Chk1p histidine kinase mutants of Candida albicans are hypersensitive to fluconazole and voriconazole. |
| AID604068 | Antifungal activity against Issatchenkia orientalis MTCC 3020 after 18 hrs by microtiter broth dilution method | 2011 | European journal of medicinal chemistry, Jul, Volume: 46, Issue:7 | Total synthesis of racemic and (R) and (S)-4-methoxyalkanoic acids and their antifungal activity. |
| AID1689821 | Antifungal activity against fluconazole-sensitive Candida glabrata CAGL2 assessed as reduction in microbial growth after 24 hrs by resazurin staining based spectrofluorometric method | 2020 | European journal of medicinal chemistry, Mar-01, Volume: 189 | New azole antifungals with a fused triazinone scaffold. |
| AID582251 | Antifungal activity against Candida albicans isolated from neutropenic subjects with AML or MDS prior to initiation of fluconazole therapy assessed as maximum MIC by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Impact of antifungal prophylaxis on colonization and azole susceptibility of Candida species. |
| AID584371 | Ratio of CDR2 gene expression in Candida glabrata isolated from patient 002 receiving antifungal drug to CDR2 gene expression in Candida glabrata isolated from patient 002 by RT-PCR analysis | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Impact of antifungal prophylaxis on colonization and azole susceptibility of Candida species. |
| AID1246767 | Antifungal activity against Cryptococcus gattii ATCC 24065 after 48 to 72 hrs by broth microdilution method | 2015 | European journal of medicinal chemistry, Sep-18, Volume: 102 | Thiazole compounds with activity against Cryptococcus gattii and Cryptococcus neoformans in vitro. |
| AID1742134 | Antifungal activity against fluconazole-resistant Candida albicans 901 assessed as inhibition of microbial growth by two fold broth microdilution method | 2020 | European journal of medicinal chemistry, Nov-01, Volume: 205 | Design, synthesis and bioactivity evaluation of novel arylalkene-amide derivatives as dual-target antifungal inhibitors. |
| AID1890293 | Inhibition of CYP51 in mouse NIH/3T3 cells assessed as specific enzymatic activity at 50 ug/ml incubated for 48 hrs by ELISA analysis | 2022 | Bioorganic & medicinal chemistry letters, 05-01, Volume: 63 | Novel 2-aryl-4-aryloxyquinoline-based fungistatics for Mucor circinelloides. Biological evaluation of activity, QSAR and docking study. |
| AID655721 | Antifungal activity against Trichoderma viride MTCC 1107 at 20 uM/ml after 48 hrs by paper disc diffusion method | 2012 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 22, Issue:8 | Design, synthesis, synergistic antimicrobial activity and cytotoxicity of 4-aryl substituted 3,4-dihydropyrimidinones of curcumin. |
| AID45348 | In vitro antifungal activity against Candida albicans | 2003 | Journal of medicinal chemistry, Feb-13, Volume: 46, Issue:4 | Structure-based de novo design, synthesis, and biological evaluation of non-azole inhibitors specific for lanosterol 14alpha-demethylase of fungi. |
| AID1419574 | Selectivity index, ratio of EC50 for toxicity in human BEAS2B cells to MIC50 for antifungal activity against Aspergillus terreus ATCC MYA-3633 | 2017 | European journal of medicinal chemistry, Jun-16, Volume: 133 | Novel alkylated azoles as potent antifungals. |
| AID395832 | Antimicrobial activity against Escherichia coli ATCC 9637 after 24 hrs by standard microbroth dilution assay | 2009 | European journal of medicinal chemistry, Jan, Volume: 44, Issue:1 | Tetrahydronaphthyl azole oxime ethers: the conformationally rigid analogues of oxiconazole as antibacterials. |
| AID407066 | Antimicrobial activity against Candida albicans intact biofilms | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | Role for cell density in antifungal drug resistance in Candida albicans biofilms. |
| AID1585630 | Antifungal activity against fluconazole-resistant Candida albicans isolate 17 cultured in YNB media after 48 hrs by broth microdilution method | 2019 | European journal of medicinal chemistry, Jan-15, Volume: 162 | Chemical preparation, biological evaluation and 3D-QSAR of ethoxysulfuron derivatives as novel antifungal agents targeting acetohydroxyacid synthase. |
| AID1877328 | Inhibition of CYP51 in Candida albicans SC3514 assessed as decrease in ergosterol biosynthesis by measuring unknown sterol 6 level at 0.25 ug/ml incubated for 16 hrs by GC-MS analysis relative to total sterols | 2022 | European journal of medicinal chemistry, Jan-05, Volume: 227 | Broadening antifungal spectrum and improving metabolic stablity based on a scaffold strategy: Design, synthesis, and evaluation of novel 4-phenyl-4,5-dihydrooxazole derivatives as potent fungistatic and fungicidal reagents. |
| AID42876 | Inhibition of Candida krusei E28 growth for 24 hours in vitro. | 2001 | Journal of medicinal chemistry, Aug-16, Volume: 44, Issue:17 | 3-Phenyl-5-acyloxymethyl-2H,5H-furan-2-ones: synthesis and biological activity of a novel group of potential antifungal drugs. |
| AID1271238 | Antifungal activity against Cryptococcus neoformans ATCC 34664 after 72 hrs by broth microdilution method | 2015 | ACS medicinal chemistry letters, Nov-12, Volume: 6, Issue:11 | Silicon Incorporated Morpholine Antifungals: Design, Synthesis, and Biological Evaluation. |
| AID1348802 | Antifungal activity against Candida parapsilosis ATCC 22019 after 48 hrs by broth microdilution method | 2018 | European journal of medicinal chemistry, Jan-01, Volume: 143 | Substituted carbamothioic amine-1-carbothioic thioanhydrides as novel trichomonicidal fungicides: Design, synthesis, and biology. |
| AID1392815 | Inhibition of Cyp51 in Candida albicans ATCC SC5314 assessed as ergosterol content at 2 ug/ml after 16 hrs by GC-MS analysis (Rvb = 98.7%) | 2018 | Bioorganic & medicinal chemistry, 07-23, Volume: 26, Issue:12 | Design, synthesis and evaluation of benzoheterocycle analogues as potent antifungal agents targeting CYP51. |
| AID1905257 | Synergistic antifungal activity against fluconazole-resistant Candida albicans 311 assessed as inhibition of fungal growth in presence of fluconazole by checker board microdilution assay | 2022 | Journal of medicinal chemistry, 04-14, Volume: 65, Issue:7 | Species-Selective Targeting of Fungal Hsp90: Design, Synthesis, and Evaluation of Novel 4,5-Diarylisoxazole Derivatives for the Combination Treatment of Azole-Resistant Candidiasis. |
| AID1728463 | Antifungal activity against fluconazole-resistant Candida albicans CaR assessed as inhibition of microbial growth by NCCLS protocol based method | 2021 | European journal of medicinal chemistry, Jan-15, Volume: 210 | Novel naphthylamide derivatives as dual-target antifungal inhibitors: Design, synthesis and biological evaluation. |
| AID527143 | Antifungal activity against Candida glabrata LMGO 44 after 5 days microdilution technique | 2010 | Journal of natural products, Oct-22, Volume: 73, Issue:10 | Search for antifungal compounds from the wood of durable tropical trees. |
| AID1728465 | Antifungal activity against fluconazole-resistant Candida albicans 901 assessed as inhibition of microbial growth by NCCLS protocol based method | 2021 | European journal of medicinal chemistry, Jan-15, Volume: 210 | Novel naphthylamide derivatives as dual-target antifungal inhibitors: Design, synthesis and biological evaluation. |
| AID279090 | Antimicrobial activity against Candida lusitaniae at 24 hrs | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Association of fluconazole area under the concentration-time curve/MIC and dose/MIC ratios with mortality in nonneutropenic patients with candidemia. |
| AID625672 | Antifungal activity against Aspergillus niger after 48 hrs by agar disk diffusion assay | 2011 | European journal of medicinal chemistry, Nov, Volume: 46, Issue:11 | L-Proline anchored multicomponent synthesis of novel pyrido[2,3-a]carbazoles; investigation of in vitro antimicrobial, antioxidant, cytotoxicity and structure activity relationship studies. |
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| AID446454 | Antifungal activity against fluconazole low-sensitive Candida krusei CK8 | 2009 | Bioorganic & medicinal chemistry letters, Oct-15, Volume: 19, Issue:20 | Design of new antifungal agents: synthesis and evaluation of 1-[(1H-indol-5-ylmethyl)amino]-2-phenyl-3-(1H-1,2,4-triazol-1-yl)propan-2-ols. |
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| AID1247371 | Antifungal activity against Candida parapsilosis 22019 after 24 hrs by serial dilution method | 2015 | European journal of medicinal chemistry, Sep-18, Volume: 102 | Design, synthesis, and structure-activity relationship studies of novel thienopyrrolidone derivatives with strong antifungal activity against Aspergillus fumigates. |
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| AID670402 | Antifungal activity against Candida albicans MTCC 183 by well diffusion method | 2012 | Bioorganic & medicinal chemistry letters, Jul-15, Volume: 22, Issue:14 | Synthesis, biological evaluation of 5-carbomethoxymethyl-7-hydroxy-2-pentylchromone, 5-carboethoxymethyl-4',7-dihydroxyflavone and their analogues. |
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| AID244909 | In vitro concentration required against Candida albicans strain YEM 15 | 2004 | Bioorganic & medicinal chemistry letters, Oct-18, Volume: 14, Issue:20 | Quinazolinone-based fungal efflux pump inhibitors. Part 1: Discovery of an (N-methylpiperazine)-containing derivative with activity in clinically relevant Candida spp. |
| AID308608 | Antifungal activity against Sporothrix schenckii | 2007 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 17, Issue:15 | Antifungal activity in triterpene glycosides from the sea cucumber Actinopyga lecanora. |
| AID1221965 | Transporter substrate index of efflux ratio in human Caco2 cells at 10 uM up to 120 mins by HPLC-MC analysis in presence of 1 uM of P-gp inhibitor LY335979 | 2011 | Drug metabolism and disposition: the biological fate of chemicals, Feb, Volume: 39, Issue:2 | Attenuation of intestinal absorption by major efflux transporters: quantitative tools and strategies using a Caco-2 model. |
| AID1872506 | In vivo antifungal activity against Candida albicans infected in CDF1 mouse treated po or iv immediately after infection measured on day 7 | 2022 | European journal of medicinal chemistry, Mar-05, Volume: 231 | Synthetic approaches and structural diversity of triazolylbutanols derived from voriconazole in the antifungal drug development. |
| AID1864919 | Toxicity in mouse infected with Candida albicans assessed as heart injury at 10 ug per 20 g, ip administered on day 2, 4, 6, 8, 10 and 12 and measured on day 14 by H and E staining based assay | |||
| AID598891 | Antimicrobial activity against mixed Candida albicans SC5314/Staphylococcus epidermidis assessed as biofilm eradication after 24 hrs | 2011 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 21, Issue:12 | Novel fungicidal benzylsulfanyl-phenylguanidines. |
| AID1187444 | Antifungal activity against Microsporum gypseum by serial dilution method | 2014 | Bioorganic & medicinal chemistry letters, Sep-01, Volume: 24, Issue:17 | Scaffold hopping of sampangine: discovery of potent antifungal lead compound against Aspergillus fumigatus and Cryptococcus neoformans. |
| AID420484 | Antifungal activity against Aspergillus niger after 7 days by tube dilution method | 2009 | European journal of medicinal chemistry, May, Volume: 44, Issue:5 | Hansch analysis of substituted benzoic acid benzylidene/furan-2-yl-methylene hydrazides as antimicrobial agents. |
| AID1524624 | Antibacterial activity against Escherichia coli KCTC 1924 after 24 hrs by microtiter ELISA | 2019 | Bioorganic & medicinal chemistry letters, 05-01, Volume: 29, Issue:9 | Synthesis of novel dihydrotriazine derivatives bearing 1,3-diaryl pyrazole moieties as potential antibacterial agents. |
| AID753241 | Antifungal activity against Candida albicans ATCC 76615 after 24 hrs by two-fold serial dilution method | 2013 | European journal of medicinal chemistry, Jun, Volume: 64 | Design, synthesis and antimicrobial evaluation of novel benzimidazole type of Fluconazole analogues and their synergistic effects with Chloromycin, Norfloxacin and Fluconazole. |
| AID1592224 | Antifungal activity against Candida albicans assessed as reduction in cell volume at 25 to 250 nM/mL by polarizing microscopy | 2019 | Bioorganic & medicinal chemistry, 06-15, Volume: 27, Issue:12 | Design, synthesis and biological evaluation of amide-pyridine derivatives as novel dual-target (SE, CYP51) antifungal inhibitors. |
| AID516303 | Antimicrobial activity against Cryptococcus gattii serotype B isolate NIH408 assessed as concentration required for heteroresistance | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Heteroresistance of Cryptococcus gattii to fluconazole. |
| AID1689216 | Antifungal activity against Candida glabrata ATCC MYA-2950 assessed as reduction in fungal growth incubated for 24 hrs by CLSI based broth microdilution method | 2020 | European journal of medicinal chemistry, Mar-01, Volume: 189 | Oxadiazolylthiazoles as novel and selective antifungal agents. |
| AID245443 | Minimum inhibitory concentration against Candida albicans V-01-191 evaluated by in vitro agar diffusion and microbroth dilution assay | 2005 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 15, Issue:15 | Synthesis of some diguanidino 1-methyl-2,5-diaryl-1H-pyrroles as antifungal agents. |
| AID294564 | Antimicrobial activity against Staphylococcus aureus ATCC 6538 at 20 ug by disk diffusion method | 2007 | European journal of medicinal chemistry, Jun, Volume: 42, Issue:6 | Rapid synthesis of sulfone derivatives as potential anti-infectious agents. |
| AID1494190 | Antifungal activity against Candida parapsilosis isolate CP2 measured after 48 hrs by CLSI M27-A3 protocol based method | 2018 | Bioorganic & medicinal chemistry, 02-01, Volume: 26, Issue:3 | Novel fluconazole derivatives with promising antifungal activity. |
| AID1918353 | Induction of apoptosis in Candida albicans assessed as necrotic cells measured after 24 hrs by Annexin V-FITC/PI staining based flow cytometry (Rvb = 3.37%) | 2022 | Journal of medicinal chemistry, 11-10, Volume: 65, Issue:21 | Novel Aryl Alkamidazole Derivatives as Multifunctional Antifungal Inhibitors: Design, Synthesis, and Biological Evaluation. |
| AID1309050 | Antifungal activity against Candida albicans ATCC MYA-2310 after 48 hrs by CLSI M27-A3 method | 2016 | Bioorganic & medicinal chemistry, 08-15, Volume: 24, Issue:16 | Synthesis and investigation of novel benzimidazole derivatives as antifungal agents. |
| AID519064 | Antifungal activity against Candida parapsilosis assessed as resistant isolates after 48 hrs by broth microdilution | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | Antimicrobial activity of omiganan pentahydrochloride against contemporary fungal pathogens responsible for catheter-associated infections. |
| AID118065 | In vivo evaluation of % survival rate after peroral administration on 7th day at dose 10 mg/kg | 1995 | Journal of medicinal chemistry, Sep-29, Volume: 38, Issue:20 | Synthesis and antifungal activity of new azole derivatives containing an N-acylmorpholine ring. |
| AID1738708 | Antifungal activity against fluconazole-resistant Candida albicans CaR measured after 24 hrs by micro-broth dilution assay | 2020 | European journal of medicinal chemistry, Jul-15, Volume: 198 | Design, synthesis, and biological evaluation of novel miconazole analogues containing selenium as potent antifungal agents. |
| AID518415 | Antimicrobial activity against Cryptococcus gattii serotype B isolate RAM15 assessed as heteroresistant isolates at 2 ug/ml | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Heteroresistance of Cryptococcus gattii to fluconazole. |
| AID372243 | Fungistatic activity against Candida albicans CHK21 after 24 to 48 hrs by broth microdilution assay | 2007 | Antimicrobial agents and chemotherapy, Oct, Volume: 51, Issue:10 | The Ssk1p response regulator and Chk1p histidine kinase mutants of Candida albicans are hypersensitive to fluconazole and voriconazole. |
| AID518446 | Antimicrobial activity against Cryptococcus gattii serotype B isolate RB3 assessed as heteroresistant isolates at 4 ug/ml | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Heteroresistance of Cryptococcus gattii to fluconazole. |
| AID1602392 | Induction of cell cycle arrest in Cryptococcus neoformans H99 assessed as accumulation at G2 phase at 4 ug/ml after 24 hrs by propidium iodide-staining based FACS analysis (Rvb = 3.86%) | 2019 | Journal of medicinal chemistry, 03-14, Volume: 62, Issue:5 | Discovery of Carboline Derivatives as Potent Antifungal Agents for the Treatment of Cryptococcal Meningitis. |
| AID1246668 | Antifungal activity against Cryptococcus gattii LMM818 assessed as reduction in cell viability at 26 uM after 6 to 72 hrs by MTT assay | 2015 | European journal of medicinal chemistry, Sep-18, Volume: 102 | Thiazole compounds with activity against Cryptococcus gattii and Cryptococcus neoformans in vitro. |
| AID531184 | Antifungal activity against Trichophyton mentagrophytes ATCC 9533 at 163.3 uM after 5 days by CLSI method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Potent in vitro antifungal activities of naturally occurring acetylenic acids. |
| AID609979 | Antifungal activity against Penicillium notatum sp. at 500 ug after 24 hrs by paper disc technique relative to control | 2011 | Bioorganic & medicinal chemistry letters, Aug-15, Volume: 21, Issue:16 | Efficient synthesis of antifungal active 9-substituted-3-aryl-5H,13aH-quinolino[3,2-f][1,2,4]triazolo[4,3-b][1,2,4]triazepines in ionic liquids. |
| AID1495977 | Antifungal activity against Candida albicans infected in guinea pig skin assessed as recovery from infection at 10 mg/g administered once daily via superficial route for 15 days measured after 30 days post last dose relative to control | 2018 | Bioorganic & medicinal chemistry, 07-23, Volume: 26, Issue:12 | Efficiency of newly prepared thiazole derivatives against some cutaneous fungi. |
| AID293896 | Antimicrobial activity against Rhodotorula glutinis SYM 2209 after 48 to 72 hrs by broth microdilution method | 2007 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 17, Issue:6 | Synthesis of pseudopeptides based L-tryptophan as a potential antimicrobial agent. |
| AID417560 | Antifungal activity against Cryptococcus neoformans TIMM 0354 | 2009 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 19, Issue:5 | FR290581, a novel sordarin derivative: synthesis and antifungal activity. |
| AID1549168 | Inhibition of HDAC in azole-resistant Candida albicans 0304103 assessed as reduction in CDR2 gene expression at 32 ug/ml after 16 hrs by SYBR Green-1 dye based RT-PCR analysis | 2020 | Journal of medicinal chemistry, 05-28, Volume: 63, Issue:10 | Discovery of Novel Fungal Lanosterol 14α-Demethylase (CYP51)/Histone Deacetylase Dual Inhibitors to Treat Azole-Resistant Candidiasis. |
| AID283226 | Effect on fungal burdens in Coccidioides immitis Silveira infected CD1 mouse brain administered after 3 days of infection at 50 mg/kg, po bid after 12 days | 2007 | Antimicrobial agents and chemotherapy, Mar, Volume: 51, Issue:3 | Comparison of itraconazole and fluconazole treatments in a murine model of coccidioidal meningitis. |
| AID1602368 | Antifungal activity against Candida parapsilosis 5008 after 48 hrs by spectrophotometery | 2019 | Journal of medicinal chemistry, 03-14, Volume: 62, Issue:5 | Discovery of Carboline Derivatives as Potent Antifungal Agents for the Treatment of Cryptococcal Meningitis. |
| AID1624176 | Antifungal activity against Candida albicans NR-29367 after 24 hrs by microbroth dilution method | 2019 | Bioorganic & medicinal chemistry letters, 03-01, Volume: 29, Issue:5 | Benzimidazole tethered pyrrolo[3,4-b]quinoline with broad-spectrum activity against fungal pathogens. |
| AID1783104 | Inhibition of capsule formation in Cryptococcus neoformans H99 assessed as reduction in capsule size at 50 ug/ml incubated for 24 hrs by laser scanning confocal microscopic analysis | 2021 | European journal of medicinal chemistry, Oct-05, Volume: 221 | Lanosterol 14α-demethylase (CYP51)/histone deacetylase (HDAC) dual inhibitors for treatment of Candida tropicalis and Cryptococcus neoformans infections. |
| AID607122 | Antifungal activity against Candida mycoderma by microbroth dilution method | 2011 | Bioorganic & medicinal chemistry letters, Jul-15, Volume: 21, Issue:14 | Synthesis and activities of naphthalimide azoles as a new type of antibacterial and antifungal agents. |
| AID519685 | Antimicrobial activity against Saccharomyces cerevisiae containing disruption in CYS3 gene by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Genomewide screening for genes associated with gliotoxin resistance and sensitivity in Saccharomyces cerevisiae. |
| AID1549158 | Inhibition of CYP51 in azole-resistant Candida albicans 0304103 assessed as unknown sterol 4 level at 0.5 ug/ml after 24 hrs by GC-MS analysis (Rvb = 1.29%) | 2020 | Journal of medicinal chemistry, 05-28, Volume: 63, Issue:10 | Discovery of Novel Fungal Lanosterol 14α-Demethylase (CYP51)/Histone Deacetylase Dual Inhibitors to Treat Azole-Resistant Candidiasis. |
| AID283232 | Reduction of fungal burden in Coccidioides immitis Silveira infected po dosed CD1 mouse brain, spinal cord, lung, kidney administered twice daily after 3 days of infection measured after 5 days relative to control | 2007 | Antimicrobial agents and chemotherapy, Mar, Volume: 51, Issue:3 | Comparison of itraconazole and fluconazole treatments in a murine model of coccidioidal meningitis. |
| AID302124 | Antifungal activity against fluconazole-resistant Candida albicans 18 after 24 hrs | 2007 | Journal of medicinal chemistry, Nov-01, Volume: 50, Issue:22 | Synthesis and antifungal activities of novel 2-aminotetralin derivatives. |
| AID1754365 | Antifungal activity against Candida krusei ATCC 6258 assessed as reduction in fungal growth incubated for 48 hrs by broth microdilution method based spectrophotometric analysis | 2021 | Bioorganic & medicinal chemistry, 07-01, Volume: 41 | Iodinated 1,2-diacylhydrazines, benzohydrazide-hydrazones and their analogues as dual antimicrobial and cytotoxic agents. |
| AID554716 | Antimicrobial activity against Candida krusei NZCDC 90.147 after 48 hrs by CLSI method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Abc1p is a multidrug efflux transporter that tips the balance in favor of innate azole resistance in Candida krusei. |
| AID1419549 | Selectivity index, ratio of EC50 for toxicity in human A549 cells to MIC50 for antifungal activity against ITC and FLC-resistant Candida albicans ATCC 1237 | 2017 | European journal of medicinal chemistry, Jun-16, Volume: 133 | Novel alkylated azoles as potent antifungals. |
| AID752004 | Antifungal activity against Candida albicans NCIM 3471 by agar dilution method | 2013 | Bioorganic & medicinal chemistry letters, May-01, Volume: 23, Issue:9 | Green synthesis of tetrahydropyrimidine analogues and evaluation of their antimicrobial activity. |
| AID584399 | Antifungal activity against 59 days cultured Candida glabrata isolated from HSCT recipient with acute or chronic GVHD mouth receiving antifungal therapy for 75 days after 33 days of prophylaxis by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Impact of antifungal prophylaxis on colonization and azole susceptibility of Candida species. |
| AID521975 | Antibacterial activity against Fluconazole resistant Candida albicans DSY296 overexpressing multidrug transporter gene CDR1 and CDR2 and containing ERG11 G464S mutation containing CIp10 to restore URA3 function infected in BALB/c mouse assessed as reducti | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Genetic dissection of azole resistance mechanisms in Candida albicans and their validation in a mouse model of disseminated infection. |
| AID603347 | Antifungal activity against Microsporum gypseum clinical isolate by micro-broth dilution method | 2011 | European journal of medicinal chemistry, Jul, Volume: 46, Issue:7 | Design, synthesis and molecular docking studies of novel triazole as antifungal agent. |
| AID510309 | Antimicrobial activity against flucytosine, azole, and caspofungin resistant Candida glabrata bloodstream isolate 3 harboring Fur1 G109D mutation serially obtained from hematopoietic stem cell transplant recipient by Etest | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Acquisition of flucytosine, azole, and caspofungin resistance in Candida glabrata bloodstream isolates serially obtained from a hematopoietic stem cell transplant recipient. |
| AID584594 | Antifungal activity against 43 days cultured Candida glabrata isolated from HSCT recipient with acute or chronic GVHD mouth receiving antifungal therapy for 172 days after 114 days of prophylaxis by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Impact of antifungal prophylaxis on colonization and azole susceptibility of Candida species. |
| AID356369 | Antifungal activity against Candida albicans ATCC 90028 by sphingolipid reversal assay in presence of 15 ug/mL stearylamine | 2003 | Journal of natural products, Aug, Volume: 66, Issue:8 | Acetylenic acids inhibiting azole-resistant Candida albicans from Pentagonia gigantifolia. |
| AID440316 | Anticandidal activity against Candida parapsilosis 81E after 24 hrs by spectrophotometry | 2009 | Journal of medicinal chemistry, Dec-10, Volume: 52, Issue:23 | Synthesis of new linear guanidines and macrocyclic amidinourea derivatives endowed with high antifungal activity against Candida spp. and Aspergillus spp. |
| AID465555 | Antifungal activity against Candida albicans by NCCLS broth microdilution method | 2010 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 20, Issue:5 | Stereospecific synthesis of oximes and oxime ethers of 3-azabicycles: A SAR study towards antimicrobial agents. |
| AID1886042 | Synergistic antifungal activity against Cryptococcus neoformans clinical isolate HN15 assessed as fractional inhibitory concentration index incubated for 72 hrs in presence of P163-0892 by broth microdilution method | |||
| AID545279 | Antifungal activity against Absidia corymbifera 272 after 48 hrs by broth microdilution method | 2010 | European journal of medicinal chemistry, Dec, Volume: 45, Issue:12 | New amino acid esters of salicylanilides active against MDR-TB and other microbes. |
| AID386930 | Antifungal activity against Candida albicans ATCC 10231 after 48 hrs by broth microdilution technique | 2008 | European journal of medicinal chemistry, Oct, Volume: 43, Issue:10 | Carbodithioic acid esters of fluoxetine, a novel class of dual-function spermicides. |
| AID604067 | Antifungal activity against Aspergillus niger MTCC 281 after 18 hrs by microtiter broth dilution method | 2011 | European journal of medicinal chemistry, Jul, Volume: 46, Issue:7 | Total synthesis of racemic and (R) and (S)-4-methoxyalkanoic acids and their antifungal activity. |
| AID424644 | Antimicrobial activity against azole-resistant Candida albicans isolate CA10 assessed as growth at 8 ug/ml cotreated with 0.125 ug/ml calcineurin signaling inhibitor Tacrolimus after 48 hrs by microdilution checkboard technique relative to control | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | In vitro interactions between tacrolimus and azoles against Candida albicans determined by different methods. |
| AID1246589 | Antifungal activity against Cryptococcus neoformans CN31 after 48 to 72 hrs by broth microdilution method | 2015 | European journal of medicinal chemistry, Sep-18, Volume: 102 | Thiazole compounds with activity against Cryptococcus gattii and Cryptococcus neoformans in vitro. |
| AID1886118 | Antifungal activity against Cryptococcus gattii WM178 infected in Wax moth larvae assessed as survival rate at 10 mg/kg measured after 9 days by Kaplan-Meier method | |||
| AID392362 | Antifungal activity against Candida krusei E28 after 24 hrs by broth microdilution method | 2009 | Bioorganic & medicinal chemistry letters, Jan-15, Volume: 19, Issue:2 | Salicylanilide esters of N-protected amino acids as novel antimicrobial agents. |
| AID518173 | Antimicrobial activity against Cryptococcus gattii serotype B isolate NIH412 assessed as heteroresistant isolates at 2 ug/ml | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Heteroresistance of Cryptococcus gattii to fluconazole. |
| AID560145 | Antifungal activity against Candida glabrata isolate 22853 by Etest method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Hypersusceptibility to azole antifungals in a clinical isolate of Candida glabrata with reduced aerobic growth. |
| AID1888263 | Antifungal activity against fluconazole resistant Candida albicans strain 17# assessed as fungal growth inhibition measured after 72 hrs by CLSI protocol based liquid medium dilution method | |||
| AID1239803 | Inhibition of Candida albicans lanosterol 14-alpha demethylase assessed as reduction of ergosterol biosynthesis at 100 ug/ml after 18 hrs by UV spectroscopy analysis | 2015 | Bioorganic & medicinal chemistry letters, Sep-01, Volume: 25, Issue:17 | Design, synthesis and evaluation of benzotriazole derivatives as novel antifungal agents. |
| AID653261 | Antifungal activity against Microsporum gypseum after 48 hrs by broth microdilution method | 2012 | Bioorganic & medicinal chemistry, Apr-15, Volume: 20, Issue:8 | Semisynthesis and antimicrobial activity of novel guttiferone-A derivatives. |
| AID1242646 | Antifungal activity against Candida albicans after 16 hrs by microtiter broth dilution method | 2015 | ACS medicinal chemistry letters, Jul-09, Volume: 6, Issue:7 | Novel Chalcone-Thiazole Hybrids as Potent Inhibitors of Drug Resistant Staphylococcus aureus. |
| AID1550459 | Antifungal activity against Saccharomyces cerevisiae ATCC 9763 assessed as decrease in fungal cell growth incubated for 24 hrs by E-test | 2019 | European journal of medicinal chemistry, Jun-01, Volume: 171 | Antimicrobial and KPC/AmpC inhibitory activity of functionalized benzosiloxaboroles. |
| AID561428 | Antifungal activity against Candida lusitaniae CL29 by microdilution method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Nonsense and missense mutations in FCY2 and FCY1 genes are responsible for flucytosine resistance and flucytosine-fluconazole cross-resistance in clinical isolates of Candida lusitaniae. |
| AID594945 | Antimicrobial activity against Candida krusei after 24 hrs by NCCLS method | 2011 | European journal of medicinal chemistry, May, Volume: 46, Issue:5 | Design and synthesis of antifungal benzoheterocyclic derivatives by scaffold hopping. |
| AID682978 | Antifungal activity against Candida parapsilosis ATCC 22019 after 48 hrs by broth microdilution method | 2012 | European journal of medicinal chemistry, Oct, Volume: 56 | Micelles catalyzed chemo- and regio-selective one pot and one step synthesis of 2,3,5,6-tetrakis(alkyl and arylsulfanyl)-1,4-benzoquinones and 2,5-diaminosubstituted-1,4-benzoquinones "In-Water" and their biological evaluation as antibacterial and antifun |
| AID304977 | Antifungal activity against Candida parapsilosis ATCC 22019 by broth micro-dilution technique | 2007 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 17, Issue:1 | New antifungal flavonoid glycoside from Vitex negundo. |
| AID719447 | Antifungal activity against Chrysosporium keratinophilum MTCC 2827 at 500 ug/mL after 72 hrs by well plate method | 2012 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 22, Issue:24 | Synthesis, antioxidant and antimicrobial activity of novel vanillin derived piperidin-4-one oxime esters: preponderant role of the phenyl ester substituents on the piperidin-4-one oxime core. |
| AID1738740 | Inhibition of CYP51 in azole-resistant Candida albicans ATCC SC531 assessed as Lanosterol level at 0.5 ug/ml incubated for 16 hrs by LC-MS analysis relative to control | 2020 | European journal of medicinal chemistry, Jul-15, Volume: 198 | Design, synthesis, and biological evaluation of novel miconazole analogues containing selenium as potent antifungal agents. |
| AID1885959 | Antifungal activity against Candida glabrata ATCC1182 assessed as fungal growth inhibition incubated for 48 hrs by broth microdilution method | |||
| AID1383920 | Antifungal activity against Aspergillus flavus after 24 hrs by NCCLS micro broth dilution method | 2018 | European journal of medicinal chemistry, Apr-25, Volume: 150 | Molecular interaction of novel benzothiazolyl triazolium analogues with calf thymus DNA and HSA-their biological investigation as potent antimicrobial agents. |
| AID293888 | Antifungal activity against Candida albicans CMAM 0594 after 48 to 72 hrs by broth microdilution method | 2007 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 17, Issue:6 | Synthesis of pseudopeptides based L-tryptophan as a potential antimicrobial agent. |
| AID681138 | TP_TRANSPORTER: increase in Calcein-AM intracellular accumulation in mdr1b-expressing LLC-PK1 cells | 2002 | The Journal of pharmacology and experimental therapeutics, Oct, Volume: 303, Issue:1 | Interaction of cytochrome P450 3A inhibitors with P-glycoprotein. |
| AID1392808 | Antifungal activity against Candida albicans CPCC 400523 after 24 hrs by serial dilution method | 2018 | Bioorganic & medicinal chemistry, 07-23, Volume: 26, Issue:12 | Design, synthesis and evaluation of benzoheterocycle analogues as potent antifungal agents targeting CYP51. |
| AID1595046 | Antifungal activity against Candida parapsilosis ATCC 22019 assessed as reduction in fungal cell growth incubated for 48 hrs by broth microdilution method | 2019 | European journal of medicinal chemistry, May-15, Volume: 170 | Tetrazole hybrids and their antifungal activities. |
| AID490313 | Antimicrobial activity against Candida albicans ATCC 10231 at 4 ug/disk by disk diffusion method | 2010 | European journal of medicinal chemistry, Jul, Volume: 45, Issue:7 | Synthesis and biological evaluation of some thio containing pyrrolo [2,3-d]pyrimidine derivatives for their anti-inflammatory and anti-microbial activities. |
| AID574601 | Antifungal activity against Candida krusei E28 after 24 hrs by broth microdilution method | 2011 | Bioorganic & medicinal chemistry, Feb-15, Volume: 19, Issue:4 | Synthesis and antimycobacterial properties of N-substituted 6-amino-5-cyanopyrazine-2-carboxamides. |
| AID279123 | Ratio of weight normalized daily dose in candidemia patient to MIC at 48 hrs against Candida albicans | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Association of fluconazole area under the concentration-time curve/MIC and dose/MIC ratios with mortality in nonneutropenic patients with candidemia. |
| AID598888 | Fungal activity against Candida glabrata BG2 assessed as concentration required to less than 0.1% survival of organism after 2 hrs | 2011 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 21, Issue:12 | Novel fungicidal benzylsulfanyl-phenylguanidines. |
| AID1456582 | Antifungal activity against Trichophyton rubrum isolate cmccftla by micro-broth dilution method | 2017 | Bioorganic & medicinal chemistry letters, 05-15, Volume: 27, Issue:10 | Design, synthesis, and in vitro evaluation of novel antifungal triazoles. |
| AID531241 | Antifungal activity against Candida glabrata assessed as susceptible isolates after 48 hrs by CLSI method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | In vitro susceptibilities of invasive isolates of Candida species: rapid increase in rates of fluconazole susceptible-dose dependent Candida glabrata isolates. |
| AID1054564 | Antifungal activity against Cryptococcus neoformans after 48 hrs by broth microdilution technique | 2013 | European journal of medicinal chemistry, , Volume: 70 | Azole-carbodithioate hybrids as vaginal anti-Candida contraceptive agents: design, synthesis and docking studies. |
| AID1079949 | Proposed mechanism(s) of liver damage. [column 'MEC' in source] | |||
| AID352098 | Antimicrobial activity against Candida albicans ATCC 10231 after 24 to 48 hrs | 2009 | European journal of medicinal chemistry, Feb, Volume: 44, Issue:2 | Synthesis, biological evaluation and 2D-QSAR analysis of benzoxazoles as antimicrobial agents. |
| AID405058 | Antifungal activity against Sporothrix schenckii P14036 isolate from cutaneous-lymphatic sporotrichosis patient after 72 hrs by Sensititre YeastOne method | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | In vitro susceptibility of Sporothrix schenckii to six antifungal agents determined using three different methods. |
| AID323073 | Antifungal activity against Cryptococcus neoformans IM 031631 by micro-broth dilution method | 2008 | Bioorganic & medicinal chemistry, Jan-15, Volume: 16, Issue:2 | Antifungal and cytotoxic activities of some N-substituted aniline derivatives bearing a hetaryl fragment. |
| AID45331 | Evaluation of In vivo antifungal activity against Candida albicans 60 by broth macro dilution method | 1995 | Journal of medicinal chemistry, Sep-29, Volume: 38, Issue:20 | Synthesis and antifungal activity of new azole derivatives containing an N-acylmorpholine ring. |
| AID1472623 | In vitro antifungal activity against Trichophyton rubrum after 7 days by serial dilution method | 2018 | Journal of medicinal chemistry, 01-11, Volume: 61, Issue:1 | Novel Terminal Bipheny-Based Diapophytoene Desaturases (CrtN) Inhibitors as Anti-MRSA/VISR/LRSA Agents with Reduced hERG Activity. |
| AID45325 | Evaluation of In vitro antifungal activity against Candida albicans 31 by broth macro dilution method | 1995 | Journal of medicinal chemistry, Sep-29, Volume: 38, Issue:20 | Synthesis and antifungal activity of new azole derivatives containing an N-acylmorpholine ring. |
| AID566891 | Antifungal activity against Exophiala xenobiotica by microdilution test | 2011 | European journal of medicinal chemistry, Jan, Volume: 46, Issue:1 | Synthesis and antifungal activity of some substituted phenothiazines and related compounds. |
| AID1595083 | Antifungal activity against Candida krusei assessed as reduction in fungal cell growth incubated for 24 hrs by broth microdilution method | 2019 | European journal of medicinal chemistry, May-15, Volume: 170 | Tetrazole hybrids and their antifungal activities. |
| AID73613 | The compound was tested in vitro for antifungal activity against 6 filamentous fungi. | 1998 | Journal of medicinal chemistry, May-21, Volume: 41, Issue:11 | New azole antifungals. 2. Synthesis and antifungal activity of heterocyclecarboxamide derivatives of 3-amino-2-aryl-1-azolyl-2-butanol. |
| AID515011 | Antifungal activity against Candida parapsilosis by micro-broth dilution method | 2010 | European journal of medicinal chemistry, Oct, Volume: 45, Issue:10 | Synthesis and antifungal evaluation of novel triazole derivatives as inhibitors of cytochrome P450 14alpha-demethylase. |
| AID42677 | In vitro antifungal activity against Candida albicans 4711E | 2002 | Journal of medicinal chemistry, Oct-24, Volume: 45, Issue:22 | Synthesis, antifungal activity, and molecular modeling studies of new inverted oxime ethers of oxiconazole. |
| AID1309054 | Antifungal activity against Candida krusei ATCC 6258 after 48 hrs by CLSI M27-A3 method | 2016 | Bioorganic & medicinal chemistry, 08-15, Volume: 24, Issue:16 | Synthesis and investigation of novel benzimidazole derivatives as antifungal agents. |
| AID682796 | Antifungal activity against Sporothrix schenckii after 72 hrs by broth microdilution method | 2012 | European journal of medicinal chemistry, Oct, Volume: 56 | Micelles catalyzed chemo- and regio-selective one pot and one step synthesis of 2,3,5,6-tetrakis(alkyl and arylsulfanyl)-1,4-benzoquinones and 2,5-diaminosubstituted-1,4-benzoquinones "In-Water" and their biological evaluation as antibacterial and antifun |
| AID1885954 | Antifungal activity against Cryptococcus neoformans H99 assessed as fungal growth inhibition incubated for 72 hrs by broth microdilution method | |||
| AID687244 | Antifungal activity against Aspergillus niger ATCC 9029 after 2 days by microdilution broth method | 2012 | Bioorganic & medicinal chemistry letters, Oct-15, Volume: 22, Issue:20 | Synthesis and pharmacological evaluation of a novel series of 3-aryl-2-(2-substituted-4-methylthiazole-5-yl)thiazolidin-4-one as possible anti-inflammatory and antimicrobial agents. |
| AID1205743 | Antifungal activity against Cryptococcus gattii ICB 181 after 72 hrs by microdilution method | 2015 | ACS medicinal chemistry letters, Mar-12, Volume: 6, Issue:3 | Synthesis of a New Peptide-Coumarin Conjugate: A Potential Agent against Cryptococcosis. |
| AID1408104 | Antibacterial activity against Staphylococcus aureus ATCC 29213 after 24 hrs by two-fold serial dilution method | 2018 | European journal of medicinal chemistry, Sep-05, Volume: 157 | Design, synthesis, antimicrobial, antiquorum-sensing and antitumor evaluation of new series of pyrazolopyridine derivatives. |
| AID425139 | Antimicrobial activity against azole-resistant Candida albicans isolate CA10 assessed as growth at 0.5 ug/ml after 48 hrs by microdilution checkerboard technique relative to control | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | In vitro interactions between tacrolimus and azoles against Candida albicans determined by different methods. |
| AID566881 | Antifungal activity against Candida guilliermondii by microdilution test | 2011 | European journal of medicinal chemistry, Jan, Volume: 46, Issue:1 | Synthesis and antifungal activity of some substituted phenothiazines and related compounds. |
| AID1592223 | Antifungal activity against Candida albicans assessed as induction of microbial cell killing at 25 to 250 nM/mL by polarizing microscopy | 2019 | Bioorganic & medicinal chemistry, 06-15, Volume: 27, Issue:12 | Design, synthesis and biological evaluation of amide-pyridine derivatives as novel dual-target (SE, CYP51) antifungal inhibitors. |
| AID245044 | In-vitro minimum inhibitory concentration against the growth of Candida parapsilosis (ATCC 22019) | 2005 | Bioorganic & medicinal chemistry letters, Jul-01, Volume: 15, Issue:13 | Synthesis of (1,4)-naphthoquinono-[3,2-c]-1H-pyrazoles and their (1,4)-naphthohydroquinone derivatives as antifungal, antibacterial, and anticancer agents. |
| AID407015 | Antimicrobial activity against Cdr1, Cdr2 and Mdr1 deficient Candida albicans DSY1050 dissociated biofilms at cell density of 10'3 cells/ml after 48 hrs by XTT assay | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | Role for cell density in antifungal drug resistance in Candida albicans biofilms. |
| AID1585632 | Antifungal activity against fluconazole-resistant Candida albicans isolate g5 cultured in YNB media after 24 hrs by broth microdilution method | 2019 | European journal of medicinal chemistry, Jan-15, Volume: 162 | Chemical preparation, biological evaluation and 3D-QSAR of ethoxysulfuron derivatives as novel antifungal agents targeting acetohydroxyacid synthase. |
| AID19262 | Aqueous solubility | 2000 | Bioorganic & medicinal chemistry letters, Jun-05, Volume: 10, Issue:11 | Prediction of drug solubility from Monte Carlo simulations. |
| AID1419545 | Selectivity index, ratio of EC50 for toxicity in human A549 cells to MIC50 for antifungal activity against ITC and FLC-resistant Candida albicans ATCC MYA-90819 | 2017 | European journal of medicinal chemistry, Jun-16, Volume: 133 | Novel alkylated azoles as potent antifungals. |
| AID1662935 | Antifungal activity against Geotrichum candidum assessed as fungal growth inhibition by micro-dilution method | 2020 | Bioorganic & medicinal chemistry letters, 07-01, Volume: 30, Issue:13 | Design, synthesis and evaluation of hydrazine and acyl hydrazone derivatives of 5-pyrrolidin-2-one as antifungal agents. |
| AID1487213 | Inhibition of CYP51 in Candida albicans assessed as inhibition of microbe growth incubated for 48 hrs by CLSI M27-A3 guideline based method | 2017 | Bioorganic & medicinal chemistry letters, 08-01, Volume: 27, Issue:15 | Design and optimization of highly-selective, broad spectrum fungal CYP51 inhibitors. |
| AID531183 | Antifungal activity against Candida albicans ATCC 32354 after 48 hrs by CLSI method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Potent in vitro antifungal activities of naturally occurring acetylenic acids. |
| AID704463 | Antifungal activity against Candida guilliermondii CLY 308 after 24 hrs by NCCLS broth microdilution method | 2012 | ACS medicinal chemistry letters, Oct-11, Volume: 3, Issue:10 | Antifungal spectrum, in vivo efficacy, and structure-activity relationship of ilicicolin h. |
| AID1192376 | Antimicrobial activity against Candida albicans MTCC 183 after 48 to 72 hrs by broth micro dilution method | 2015 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 25, Issue:7 | Synthesis and antimicrobial activity of novel benzoxazine sulfonamide derivatives. |
| AID1302233 | Antifungal activity against azole-susceptible Candida albicans isolate DSY294 in immunocompetent Balb/c mouse candidiasis model assessed as reduction in CFU count in kidney at 8 mg/kg/day, ip regime measured on day 7 post infection | 2016 | Journal of medicinal chemistry, 04-28, Volume: 59, Issue:8 | Biological Characterization and in Vivo Assessment of the Activity of a New Synthetic Macrocyclic Antifungal Compound. |
| AID1689224 | Antifungal activity against Cryptococcus gattii NR43210 assessed as reduction in fungal growth incubated for 48 hrs by CLSI based broth microdilution method | 2020 | European journal of medicinal chemistry, Mar-01, Volume: 189 | Oxadiazolylthiazoles as novel and selective antifungal agents. |
| AID521800 | Antifungal activity against fluconazole-susceptible Candida glabrata isolate 4205 infected neutropenic CD1 mouse disseminated candidiasis model assessed as reduction in kidney tissue fungal burden at 30 mg/kg/day, po administered 24 hrs post infection mea | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Posaconazole against Candida glabrata isolates with various susceptibilities to fluconazole. |
| AID563131 | Antifungal activity against Candida glabrata ATCC 90030 infected in ICR mouse assessed as fungal load in kidney at 2.5 mg/kg/day, sc for 8 days measured on day 8 | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | T-2307 shows efficacy in a murine model of Candida glabrata infection despite in vitro trailing growth phenomena. |
| AID1126884 | Antifungal activity against Candida albicans ATCC 90028 assessed as growth inhibition after 18 hrs by two-fold serial dilution method | 2014 | European journal of medicinal chemistry, May-06, Volume: 78 | Searching for new derivatives of neocryptolepine: synthesis, antiproliferative, antimicrobial and antifungal activities. |
| AID516263 | Antimicrobial activity against Cryptococcus gattii serotype B isolate NIH744 assessed as concentration required for heteroresistance | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Heteroresistance of Cryptococcus gattii to fluconazole. |
| AID448157 | Antimicrobial activity against Yersinia pseudotuberculosis ATCC 911 at 5 ug after 18 hrs by well diffusion method | 2009 | European journal of medicinal chemistry, Nov, Volume: 44, Issue:11 | Synthesis of some new 1,2,4-triazoles starting from isonicotinic acid hydrazide and evaluation of their antimicrobial activities. |
| AID551210 | Antifungal activity against Fusarium by broth microdilution method | 2011 | Bioorganic & medicinal chemistry letters, Jan-15, Volume: 21, Issue:2 | New azoles with antifungal activity: Design, synthesis, and molecular docking. |
| AID719448 | Antifungal activity against Chrysosporium keratinophilum MTCC 2827 at 1000 ug/mL after 72 hrs by well plate method | 2012 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 22, Issue:24 | Synthesis, antioxidant and antimicrobial activity of novel vanillin derived piperidin-4-one oxime esters: preponderant role of the phenyl ester substituents on the piperidin-4-one oxime core. |
| AID1274475 | Antifungal activity against Cryptococcus neoformans ATCC 32719 after 24 hrs by two-fold serial dilution method | 2016 | European journal of medicinal chemistry, Jan-27, Volume: 108 | Synthesis and biological evaluation of novel phosphoramidate derivatives of coumarin as chitin synthase inhibitors and antifungal agents. |
| AID294191 | Antibacterial activity against Escherichia coli ATCC 25922 at 100 ug/ml by diffusion method | 2007 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 17, Issue:8 | Synthesis and antimicrobial activity of some novel phenyl and benzimidazole substituted benzyl ethers. |
| AID1157158 | Antifungal activity against Candida tropicalis DSM 11953 after 48 hrs by CLSI broth microdilution method | 2014 | European journal of medicinal chemistry, Aug-18, Volume: 83 | Synthesis, biological evaluation and structure-activity correlation study of a series of imidazol-based compounds as Candida albicans inhibitors. |
| AID522127 | Antimicrobial activity against Candida glabrata TG172 containing deltacrz1 mutant by colorimetric microdilution method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Roles of calcineurin and Crz1 in antifungal susceptibility and virulence of Candida glabrata. |
| AID1419567 | Selectivity index, ratio of EC50 for toxicity in human A549 cells to MIC50 for antifungal activity against Candida krusei ATCC 6258 | 2017 | European journal of medicinal chemistry, Jun-16, Volume: 133 | Novel alkylated azoles as potent antifungals. |
| AID49963 | Minimum inhibitory concentration against Candida glabrata | 2002 | Bioorganic & medicinal chemistry letters, Aug-19, Volume: 12, Issue:16 | Antifungal activity of bifunctional sphingolipids. Intramolecular synergism within long-chain alpha,omega-bis-aminoalcohols. |
| AID1063943 | Antifungal activity against Trichophyton mentagrophytes 445 after 120 hrs by broth microdilution method | 2014 | Bioorganic & medicinal chemistry, Jan-15, Volume: 22, Issue:2 | Salicylanilide diethyl phosphates: synthesis, antimicrobial activity and cytotoxicity. |
| AID405028 | Antifungal activity against Sporothrix schenckii MRSS4 isolate from cutaneous-lymphatic sporotrichosis patient after 72 hrs by Sensititre YeastOne method | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | In vitro susceptibility of Sporothrix schenckii to six antifungal agents determined using three different methods. |
| AID1154852 | Antifungal activity against fluconazole-sensitive Candida albicans SC5314 assessed as change in lanosterol composition at 8 ug/ml after 24 hrs by GC-MS analysis (Rvb = 1.5%) | 2014 | ACS medicinal chemistry letters, May-08, Volume: 5, Issue:5 | Novel carboline derivatives as potent antifungal lead compounds: design, synthesis, and biological evaluation. |
| AID351035 | Antimicrobial activity against Candida parapsilosis after 72 hrs by broth microdilution method | 2009 | European journal of medicinal chemistry, Mar, Volume: 44, Issue:3 | 2-Acylhydrazino-5-arylpyrrole derivatives: synthesis and antifungal activity evaluation. |
| AID717790 | Antimicrobial activity against Trichosporon beigelii 1188 after 24 hrs by broth microdilution test | 2012 | Bioorganic & medicinal chemistry, Dec-15, Volume: 20, Issue:24 | Contribution to investigation of antimicrobial activity of styrylquinolines. |
| AID1758036 | Inhibition of CYP51 in Candida albicans ATCC SC5314 assessed as lanosterol level at 0.03125 ug/ml after 16 hrs by GC-MS analysis (Rvb = 1.7%) | 2021 | European journal of medicinal chemistry, Apr-15, Volume: 216 | Lead optimization generates selenium-containing miconazole CYP51 inhibitors with improved pharmacological profile for the treatment of fungal infections. |
| AID1898167 | Antifungal activity against Candida parapsilosis 90018 | |||
| AID1494189 | Antifungal activity against Candida parapsilosis isolate CP1 measured after 48 hrs by CLSI M27-A3 protocol based method | 2018 | Bioorganic & medicinal chemistry, 02-01, Volume: 26, Issue:3 | Novel fluconazole derivatives with promising antifungal activity. |
| AID1898174 | Antifungal activity against Candida krusei 467 | |||
| AID625288 | Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for jaundice | 2011 | PLoS computational biology, Dec, Volume: 7, Issue:12 | Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). |
| AID341133 | Antifungal activity against sSaccharomyces cerevisiae isolates from grapes by NCCLS M27-A2 method | 2007 | Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8 | Cross-resistance to medical and agricultural azole drugs in yeasts from the oropharynx of human immunodeficiency virus patients and from environmental Bavarian vine grapes. |
| AID549044 | Antifungal activity against Candida albicans CA1 after 48 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | In vitro activities of retigeric acid B alone and in combination with azole antifungal agents against Candida albicans. |
| AID510621 | Antifungal activity against Microsporum gypseum by serial dilution method | 2010 | European journal of medicinal chemistry, Sep, Volume: 45, Issue:9 | Design, synthesis and antifungal activity of isosteric analogues of benzoheterocyclic N-myristoyltransferase inhibitors. |
| AID1419515 | Toxicity in human BEAS2B cells assessed as reduction in cell viability incubated for 24 hrs by resazurin dye based assay | 2017 | European journal of medicinal chemistry, Jun-16, Volume: 133 | Novel alkylated azoles as potent antifungals. |
| AID1556224 | Inhibition of CYP51 in Candida albicans ATCC SC5314 assessed as lanosterol level at 0.5 ug/ml incubated for 16 hrs by GC/MS analysis (Rvb = 0%) | 2019 | European journal of medicinal chemistry, Sep-01, Volume: 177 | Design, synthesis, and structure-activity relationship studies of l-amino alcohol derivatives as broad-spectrum antifungal agents. |
| AID1592217 | Antifungal activity against Candida tropicalis ATCC 1369 assessed as inhibition of microbial growth by NCCLS protocol based method | 2019 | Bioorganic & medicinal chemistry, 06-15, Volume: 27, Issue:12 | Design, synthesis and biological evaluation of amide-pyridine derivatives as novel dual-target (SE, CYP51) antifungal inhibitors. |
| AID743893 | Antifungal activity against Candida albicans at 5 mg/mL after 48 hrs | 2013 | European journal of medicinal chemistry, May, Volume: 63 | Synthesis, antimicrobial, antiquorum-sensing, antitumor and cytotoxic activities of new series of fused [1,3,4]thiadiazoles. |
| AID562996 | Antifungal activity against Candida albicans isolate 03-2718 infected BALB/c mouse vaginitis model assessed as reduction in fungal load in vagina at 20 mg/kg, administered through oral gavage twice daily for 5 days measured on day 1 post inoculation | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | Efficacy of albaconazole against Candida albicans in a vaginitis model. |
| AID1270926 | Antibiofilm activity against Candida albicans ATCC 24433 at 1000 ug/ml after 24 hrs by XTT-based colorimetric assay | 2015 | Journal of natural products, Nov-25, Volume: 78, Issue:11 | Synergistic Antifungal Meroterpenes and Dioxolanone Derivatives from the Endophytic Fungus Guignardia sp. |
| AID1419534 | Hemolytic activity in mouse erythrocytes assessed as hemolysis level at 7.8 ug/ml incubated for 1 hr at 37 degC | 2017 | European journal of medicinal chemistry, Jun-16, Volume: 133 | Novel alkylated azoles as potent antifungals. |
| AID1411856 | Antifungal activity against fluconazole susceptible Candida albicans 0072gr by CLSI protocol based broth microdilution method | 2017 | MedChemComm, Dec-01, Volume: 8, Issue:12 | Synergistic antifungal effect of cyclized chalcone derivatives and fluconazole against |
| AID574605 | Antifungal activity against Absidia corymbifera 272 after 24 hrs by broth microdilution method | 2011 | Bioorganic & medicinal chemistry, Feb-15, Volume: 19, Issue:4 | Synthesis and antimycobacterial properties of N-substituted 6-amino-5-cyanopyrazine-2-carboxamides. |
| AID1205746 | Antifungal activity against Cryptococcus gattii 547/OTT after 72 hrs by microdilution method | 2015 | ACS medicinal chemistry letters, Mar-12, Volume: 6, Issue:3 | Synthesis of a New Peptide-Coumarin Conjugate: A Potential Agent against Cryptococcosis. |
| AID518655 | Antimicrobial activity against Cryptococcus gattii serotype B isolate NIH444 assessed as heteroresistant isolates at 8 ug/ml | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Heteroresistance of Cryptococcus gattii to fluconazole. |
| AID1556212 | Antifungal activity against Aspergillus fumigatus CGMCC 3.7795 assessed as inhibition of visible microbial growth by NCCLS protocol based method | 2019 | European journal of medicinal chemistry, Sep-01, Volume: 177 | Design, synthesis, and structure-activity relationship studies of l-amino alcohol derivatives as broad-spectrum antifungal agents. |
| AID560141 | Antifungal activity against Candida glabrata isolate 22852 at 15 ug after 48 hrs by disk diffusion method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Hypersusceptibility to azole antifungals in a clinical isolate of Candida glabrata with reduced aerobic growth. |
| AID392365 | Antifungal activity against Aspergillus fumigatus 231 after 24 hrs by broth microdilution method | 2009 | Bioorganic & medicinal chemistry letters, Jan-15, Volume: 19, Issue:2 | Salicylanilide esters of N-protected amino acids as novel antimicrobial agents. |
| AID453724 | Antifungal activity against Aspergillus flavus after 72 to 96 hrs by twofold serial dilution method | 2010 | Bioorganic & medicinal chemistry letters, Jan-15, Volume: 20, Issue:2 | Synthesis, spectral analysis and in vitro microbiological evaluation of 3-(3-alkyl-2,6-diarylpiperin-4-ylidene)-2-thioxoimidazolidin-4-ones as a new class of antibacterial and antifungal agents. |
| AID279094 | Ratio of AUC in candidemia patient to MIC against Candida tropicalis | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Association of fluconazole area under the concentration-time curve/MIC and dose/MIC ratios with mortality in nonneutropenic patients with candidemia. |
| AID444053 | Renal clearance in human | 2010 | Journal of medicinal chemistry, Feb-11, Volume: 53, Issue:3 | Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. |
| AID497807 | Antifungal activity against fluconazole-resistant Candida glabrata isolate 05 by broth microdilution assay | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Assessment of the in vitro kinetic activity of caspofungin against Candida glabrata. |
| AID551206 | Antifungal activity against Cryptococcus neoformans ATCC BLS108 after 72 hrs by broth microdilution method | 2011 | Bioorganic & medicinal chemistry letters, Jan-15, Volume: 21, Issue:2 | New azoles with antifungal activity: Design, synthesis, and molecular docking. |
| AID1061245 | Antimicrobial activity against Chrysosporium keratinophilum at 1 mg/ml by well plate method | 2014 | European journal of medicinal chemistry, Jan, Volume: 71 | Synthesis and biological evaluation of novel substituted 1,3,4-thiadiazole and 2,6-di aryl substituted imidazo [2,1-b] [1,3,4] thiadiazole derivatives. |
| AID717789 | Antimicrobial activity against Aspergillus fumigatus 231 after 24 hrs by broth microdilution test | 2012 | Bioorganic & medicinal chemistry, Dec-15, Volume: 20, Issue:24 | Contribution to investigation of antimicrobial activity of styrylquinolines. |
| AID1487498 | Antifungal activity against Candida albicans assessed as zone of inhibition at 25 ug/ml measured after 24 hrs by well diffusion method | 2017 | Bioorganic & medicinal chemistry letters, 08-15, Volume: 27, Issue:16 | Synthesis, antioxidant, antifungal, molecular docking and ADMET studies of some thiazolyl hydrazones. |
| AID1754362 | Antifungal activity against Candida albicans ATCC 24443 assessed as reduction in fungal growth incubated for 24 hrs by broth microdilution method based spectrophotometric analysis | 2021 | Bioorganic & medicinal chemistry, 07-01, Volume: 41 | Iodinated 1,2-diacylhydrazines, benzohydrazide-hydrazones and their analogues as dual antimicrobial and cytotoxic agents. |
| AID428564 | Inhibition of CYP3A4 | 2009 | European journal of medicinal chemistry, Jul, Volume: 44, Issue:7 | Comparative chemometric modeling of cytochrome 3A4 inhibitory activity of structurally diverse compounds using stepwise MLR, FA-MLR, PLS, GFA, G/PLS and ANN techniques. |
| AID704473 | Antifungal activity against Cryptococcus neoformans H 99 after 40 hrs by NCCLS broth microdilution method | 2012 | ACS medicinal chemistry letters, Oct-11, Volume: 3, Issue:10 | Antifungal spectrum, in vivo efficacy, and structure-activity relationship of ilicicolin h. |
| AID518650 | Antimicrobial activity against Cryptococcus gattii serotype C isolate H0058-1-818 assessed as heteroresistant at 4 ug/ml | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Heteroresistance of Cryptococcus gattii to fluconazole. |
| AID1411883 | Up regulation of ERG11 gene expression in fluconazole resistant Candida albicans A171 at 8 ug/ml after 2 hrs by qRT PCR analysis | 2017 | MedChemComm, Dec-01, Volume: 8, Issue:12 | Synergistic antifungal effect of cyclized chalcone derivatives and fluconazole against |
| AID725880 | Antifungal activity against Candida glabrata CAGL2 after 24 hrs by spectrofluorometric analysis | 2013 | ACS medicinal chemistry letters, Feb-14, Volume: 4, Issue:2 | Discovery of a novel broad-spectrum antifungal agent derived from albaconazole. |
| AID1506726 | Antibacterial activity against Enterobacter aerogenes MTCC 111 by agar dilution method | 2017 | MedChemComm, Mar-01, Volume: 8, Issue:3 | Design, synthesis, molecular-docking and antimycobacterial evaluation of some novel 1,2,3-triazolyl xanthenones. |
| AID425153 | Antimicrobial activity against azole-resistant Candida albicans isolate CA10 assessed as growth at 0.002 ug/ml after 48 hrs by microdilution checkerboard technique relative to control | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | In vitro interactions between tacrolimus and azoles against Candida albicans determined by different methods. |
| AID1918348 | Induction of mitochondrial membrane depolarization in Candida albicans assessed as fungal cells with depolarized mitochondria measured after 24 hrs by JC-1 staining based flow cytometry (Rvb = 3.22%) | 2022 | Journal of medicinal chemistry, 11-10, Volume: 65, Issue:21 | Novel Aryl Alkamidazole Derivatives as Multifunctional Antifungal Inhibitors: Design, Synthesis, and Biological Evaluation. |
| AID469166 | Antifungal activity against Candida albicans at MIC after 72 hrs by disk diffusion assay | 2010 | European journal of medicinal chemistry, Feb, Volume: 45, Issue:2 | Synthesis, anti-bacterial and anti-fungal activities of some novel Schiff bases containing 2,4-disubstituted thiazole ring. |
| AID1634359 | Antifungal activity against Cryptococcus neoformans cgmcc 2.3161 assessed as inhibition of visible microbe growth by broth microdilution method | 2019 | Bioorganic & medicinal chemistry letters, 09-01, Volume: 29, Issue:17 | Design, synthesis and evaluation of biphenyl imidazole analogues as potent antifungal agents. |
| AID1886043 | Synergistic antifungal activity against Cryptococcus neoformans clinical isolate HN17 assessed as fractional inhibitory concentration index incubated for 72 hrs in presence of P163-0892 by broth microdilution method | |||
| AID1309051 | Antifungal activity against Candida albicans ATCC MYA-1237 after 48 hrs by CLSI M27-A3 method | 2016 | Bioorganic & medicinal chemistry, 08-15, Volume: 24, Issue:16 | Synthesis and investigation of novel benzimidazole derivatives as antifungal agents. |
| AID518676 | Antimicrobial activity against Cryptococcus gattii serotype C isolate H0058-1-2023 assessed as heteroresistant isolates at 8 ug/ml | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Heteroresistance of Cryptococcus gattii to fluconazole. |
| AID1060888 | Antifungal activity against Candida albicans ATCC 76615 after 24 hrs by micro broth dilution method | 2014 | European journal of medicinal chemistry, Jan, Volume: 71 | Synthesis and biological evaluation of α-triazolyl chalcones as a new type of potential antimicrobial agents and their interaction with calf thymus DNA and human serum albumin. |
| AID1511411 | Antifungal activity against Candida krolimus assessed as reduction in fungal cell growth incubated for 48 hrs by serial dilution method | 2019 | Bioorganic & medicinal chemistry, 11-01, Volume: 27, Issue:21 | Synthesis and biological evaluation of calycanthaceous alkaloid analogs. |
| AID1918386 | Anti-inflammatory activity in mouse infected with Candida albicans assessed as reduction in NF-kappaB p65 expression in infection tissues at 20 mg/kg, ip administered on days 2,4,6,8,10,12 and measured on day 14 by western blot analysis | 2022 | Journal of medicinal chemistry, 11-10, Volume: 65, Issue:21 | Novel Aryl Alkamidazole Derivatives as Multifunctional Antifungal Inhibitors: Design, Synthesis, and Biological Evaluation. |
| AID1235431 | Antifungal activity against clinical isolates of Candida albicans 2323 by broth microdilution assay | 2015 | Bioorganic & medicinal chemistry, Aug-01, Volume: 23, Issue:15 | Imidazole clubbed 1,3,4-oxadiazole derivatives as potential antifungal agents. |
| AID564266 | Effect on sterol composition in Candida albicans isolate 108 harboring erg11 and erg5 double mutant assessed as obtusifoliol level after 2 hrs by gas chromatography | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | A clinical isolate of Candida albicans with mutations in ERG11 (encoding sterol 14alpha-demethylase) and ERG5 (encoding C22 desaturase) is cross resistant to azoles and amphotericin B. |
| AID1233492 | Antimicrobial activity against Malassezia pachydermatis assessed as inhibition of visual microbial growth incubated for 48 to 72 hrs at 28 degC | 2015 | Bioorganic & medicinal chemistry letters, Jul-15, Volume: 25, Issue:14 | Thiophene and benzodioxole appended thiazolyl-pyrazoline compounds: Microwave assisted synthesis, antimicrobial and molecular docking studies. |
| AID1176262 | Antifungal activity against Candida albicans after 2 to 7 days by serial plate dilution method | 2015 | Bioorganic & medicinal chemistry letters, Jan-15, Volume: 25, Issue:2 | Ionic liquid catalyzed synthesis of 2-(indole-3-yl)-thiochroman-4-ones and their novel antifungal activities. |
| AID434362 | Antifungal activity against Sporothrix schenckii after 72 hrs by broth microdilution method | 2009 | European journal of medicinal chemistry, Aug, Volume: 44, Issue:8 | Design, synthesis and biological evaluation of novel nitrogen and sulfur containing hetero-1,4-naphthoquinones as potent antifungal and antibacterial agents. |
| AID555133 | Antimicrobial activity against Candida glabrata by EUCAST broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Fenticonazole activity measured by the methods of the European Committee on Antimicrobial Susceptibility Testing and CLSI against 260 Candida vulvovaginitis isolates from two European regions and annotations on the prevalent genotypes. |
| AID1707528 | Antifungal activity against Candida albicans 0304103 infected in ICR mouse model of candidiasis assessed as reduction in fungal invasion by measuring clusters of fungal infiltration in renal pelvis at 1 mg/kg, ip dosed 24 hrs post infection and measured a | 2021 | Journal of medicinal chemistry, 01-28, Volume: 64, Issue:2 | Novel Carboline Fungal Histone Deacetylase (HDAC) Inhibitors for Combinational Treatment of Azole-Resistant Candidiasis. |
| AID1439296 | Antifungal activity against Aspergillus fumigatus at 100 ug/ml by disc diffusion method | 2017 | European journal of medicinal chemistry, Mar-10, Volume: 128 | Tetrazolylmethyl quinolines: Design, docking studies, synthesis, anticancer and antifungal analyses. |
| AID745263 | Antifungal activity against Candida tropicalis ATCC 750 after 18 to 24 hrs by micro-dilution method | 2013 | European journal of medicinal chemistry, May, Volume: 63 | Design, synthesis and antimicrobial activity of novel benzothiazole analogs. |
| AID518440 | Antimicrobial activity against Cryptococcus gattii serotype B isolate NIH286 assessed as heteroresistant isolates at 4 ug/ml | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Heteroresistance of Cryptococcus gattii to fluconazole. |
| AID1759442 | Hemolytic activity in human RBC at 8 ug/ml incubated for 30 mins | 2021 | Bioorganic & medicinal chemistry letters, 06-01, Volume: 41 | Inhibitory effects and mechanism of antifungal action of the natural cyclic depsipeptide, aureobasidin A against Cryptococcus neoformans. |
| AID655715 | Antifungal activity against Curvularia lunata MTCC 581 at 80 uM/ml after 48 hrs by paper disc diffusion method | 2012 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 22, Issue:8 | Design, synthesis, synergistic antimicrobial activity and cytotoxicity of 4-aryl substituted 3,4-dihydropyrimidinones of curcumin. |
| AID1864921 | Toxicity in mouse infected with Candida albicans assessed as ALT level in plasma at 10 ug per 20 g, ip administered on day 2, 4, 6, 8, 10 and 12 and measured on day 14 (Rvb = 43.6 +/- 4.4 IU/L) | |||
| AID369390 | Antimicrobial activity against Candida famata isolate | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | In vitro susceptibility to posaconazole of 1,903 yeast isolates recovered in France from 2003 to 2006 and tested by the method of the European committee on antimicrobial susceptibility testing. |
| AID581861 | Antifungal activity against Candida krusei isolated from neutropenic subjects with AML or MDS prior to initiation of fluconazole therapy assessed as maximum MIC by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Impact of antifungal prophylaxis on colonization and azole susceptibility of Candida species. |
| AID626349 | Antifungal activity against Candida albicans MTCC 3017 at 0.25 mg/mL after 72 hrs by by agar-well diffusion method | 2011 | European journal of medicinal chemistry, Nov, Volume: 46, Issue:11 | Hantzsch reaction: synthesis and characterization of some new 1,4-dihydropyridine derivatives as potent antimicrobial and antioxidant agents. |
| AID1511413 | Antifungal activity against Candida tropicalis assessed as reduction in fungal cell growth incubated for 48 hrs by serial dilution method | 2019 | Bioorganic & medicinal chemistry, 11-01, Volume: 27, Issue:21 | Synthesis and biological evaluation of calycanthaceous alkaloid analogs. |
| AID1904376 | Inhibition of CYP51 in Candida albicans ATCC SC5314 assessed as unknown sterol level at 0.25 ug/ml measured after 18 hrs by GC-MS analysis (Rvb = 3.07 %) | 2022 | European journal of medicinal chemistry, Apr-05, Volume: 233 | Design, synthesis, and evaluation of novel 3-thiophene derivatives as potent fungistatic and fungicidal reagents based on a conformational restriction strategy. |
| AID1595067 | Antifungal activity against Aspergillus flavus assessed as inhibition zone at 20 ug/ml by disk diffusion method | 2019 | European journal of medicinal chemistry, May-15, Volume: 170 | Tetrazole hybrids and their antifungal activities. |
| AID1890281 | Antifungal activity against Trichophyton rubrum clinical isolate 2 assessed as reduction in fungal growth by broth dilution method | 2022 | Bioorganic & medicinal chemistry letters, 05-01, Volume: 63 | Novel 2-aryl-4-aryloxyquinoline-based fungistatics for Mucor circinelloides. Biological evaluation of activity, QSAR and docking study. |
| AID424619 | Antimicrobial activity against azole-susceptible Candida albicans isolate CA8 after 48 hrs by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | In vitro interactions between tacrolimus and azoles against Candida albicans determined by different methods. |
| AID553535 | Drug accumulation in Saccharomyces cerevisiae ADCDR1 expressing Candida albicans CDR1 efflux pump reenergized with glucose at pH 6.0 assessed as intracellular accumulation after 60 mins by fluorescamine staining | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | Enhanced susceptibility to antifungal oligopeptides in yeast strains overexpressing ABC multidrug efflux pumps. |
| AID1124801 | Antifungal activity against Aspergillus fumigatus clinical isolate after 72 to 96 hrs by standard broth microdilution method | 2014 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 24, Issue:7 | Synthesis and evaluation of new diaryl ether and quinoline hybrids as potential antiplasmodial and antimicrobial agents. |
| AID1602379 | Inhibition of melanin production in Cryptococcus neoformans H99 at 2.5 ug/ml | 2019 | Journal of medicinal chemistry, 03-14, Volume: 62, Issue:5 | Discovery of Carboline Derivatives as Potent Antifungal Agents for the Treatment of Cryptococcal Meningitis. |
| AID1416194 | Antifungal activity against Candida utilis by two-fold serial dilution method | 2017 | MedChemComm, Aug-01, Volume: 8, Issue:8 | Discovery of potential antifungal triazoles: design, synthesis, biological evaluation, and preliminary antifungal mechanism exploration. |
| AID1246664 | Antifungal activity against Cryptococcus gattii 196L/03 assessed as reduction in cell viability at 26 uM after 6 to 72 hrs by MTT assay | 2015 | European journal of medicinal chemistry, Sep-18, Volume: 102 | Thiazole compounds with activity against Cryptococcus gattii and Cryptococcus neoformans in vitro. |
| AID638566 | Antifungal activity against Aspergillus niger KCTC 1231 after 2 days by two fold broth dilution method | 2012 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 22, Issue:1 | Synthesis and antifungal evaluation of pyrido[1,2-a]indole-1,4-diones and benzo[f]pyrido[1,2-a]indole-6,11-diones. |
| AID1157157 | Antifungal activity against Candida tropicalis PMC 0910 after 48 hrs by CLSI broth microdilution method | 2014 | European journal of medicinal chemistry, Aug-18, Volume: 83 | Synthesis, biological evaluation and structure-activity correlation study of a series of imidazol-based compounds as Candida albicans inhibitors. |
| AID595003 | Ratio of MIC to MFC for Candida albicans | 2011 | Bioorganic & medicinal chemistry letters, May-15, Volume: 21, Issue:10 | Thermal solvent-free synthesis of novel pyrazolyl chalcones and pyrazolines as potential antimicrobial agents. |
| AID1867417 | Antifungal activity against fluconazole resistant Candida glabrata 109 overexpressing CgCdr1p transporter assessed as reduction in fungal growth incubated for 48 hrs by serial dilution method | 2022 | Bioorganic & medicinal chemistry, 06-01, Volume: 63 | Effects of β-lapachone and β-nor-lapachone on multidrug efflux transporters and biofilms of Candida glabrata. |
| AID545278 | Antifungal activity against Absidia corymbifera 272 after 24 hrs by broth microdilution method | 2010 | European journal of medicinal chemistry, Dec, Volume: 45, Issue:12 | New amino acid esters of salicylanilides active against MDR-TB and other microbes. |
| AID674389 | Antifungal activity against Candida albicans MTCC 2827 at 0.5 mg/ml after 72 hrs by well plate method | 2012 | Bioorganic & medicinal chemistry letters, Jul-15, Volume: 22, Issue:14 | Synthesis of benzofuran based 1,3,5-substituted pyrazole derivatives: as a new class of potent antioxidants and antimicrobials--a novel accost to amend biocompatibility. |
| AID1742136 | Antifungal activity against Candida albicans ATCC SC5314 assessed as decrease in fungal cell density by polarizing microscopy | 2020 | European journal of medicinal chemistry, Nov-01, Volume: 205 | Design, synthesis and bioactivity evaluation of novel arylalkene-amide derivatives as dual-target antifungal inhibitors. |
| AID609895 | Antifungal activity against Trichophyton rubrum by micro-broth dilution method | 2011 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 21, Issue:15 | Synthesis, in vitro evaluation and molecular docking studies of new triazole derivatives as antifungal agents. |
| AID1367155 | Antifungal activity against Candida glabrata 20/I after 24 hrs by microdilution broth method | 2017 | Bioorganic & medicinal chemistry letters, 12-01, Volume: 27, Issue:23 | Synthesis and biological evolution of hydrazones derived from 4-(trifluoromethyl)benzohydrazide. |
| AID1205744 | Antifungal activity against Cryptococcus gattii L135/03 after 72 hrs by microdilution method | 2015 | ACS medicinal chemistry letters, Mar-12, Volume: 6, Issue:3 | Synthesis of a New Peptide-Coumarin Conjugate: A Potential Agent against Cryptococcosis. |
| AID352120 | Antifungal activity against Aspergillus flavus after 26 hrs by serial plate dilution method | 2009 | European journal of medicinal chemistry, Mar, Volume: 44, Issue:3 | Antimicrobial studies of some novel quinazolinones fused with [1,2,4]-triazole, [1,2,4]-triazine and [1,2,4,5]-tetrazine rings. |
| AID489937 | Antifungal activity against Aspergillus fumigatus ATCC 36607 after 24 hrs by microdilution method | 2010 | Bioorganic & medicinal chemistry letters, Jul-01, Volume: 20, Issue:13 | Novel pyridobenzimidazole derivatives exhibiting antifungal activity by the inhibition of beta-1,6-glucan synthesis. |
| AID1418531 | Antifungal activity against Cryptococcus neoformans cgmcc 2.3161 after 2 to 7 days by broth microdilution method | 2018 | Bioorganic & medicinal chemistry letters, 12-01, Volume: 28, Issue:22 | Design, synthesis, and biological evaluation of 4-chloro-2H-thiochromenes featuring nitrogen-containing side chains as potent antifungal agents. |
| AID1825531 | Anti-Cryptococcal activity against Cryptococcus neoformans infected pneumonia and encephalitis C57BL/6J mouse model assessed as reduction in pneumonia symptoms at 8 mg/kg, iv administered once a day for 9 days and measured at 24 hrs at last post-dosage | 2022 | Journal of medicinal chemistry, 02-10, Volume: 65, Issue:3 | Synthesis of Hemiprotonic Phenanthroline-Phenanthroline |
| AID1674371 | AUC in human administered as single dose | 2020 | Journal of medicinal chemistry, 11-12, Volume: 63, Issue:21 | Integrating the Impact of Lipophilicity on Potency and Pharmacokinetic Parameters Enables the Use of Diverse Chemical Space during Small Molecule Drug Optimization. |
| AID1246667 | Antifungal activity against Cryptococcus gattii L24/01 assessed as reduction in cell viability at 26 uM after 6 to 72 hrs by MTT assay | 2015 | European journal of medicinal chemistry, Sep-18, Volume: 102 | Thiazole compounds with activity against Cryptococcus gattii and Cryptococcus neoformans in vitro. |
| AID750174 | Antifungal activity against Cryptococcus neoformans after 72 hrs by NCCLS method | 2013 | European journal of medicinal chemistry, Jun, Volume: 64 | Discovery of highly potent triazole antifungal derivatives by heterocycle-benzene bioisosteric replacement. |
| AID655582 | Antifungal activity against Cryptococcus neoformans after 72 hrs by microbroth dilution method | 2012 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 22, Issue:8 | New triazole derivatives as antifungal agents: synthesis via click reaction, in vitro evaluation and molecular docking studies. |
| AID1905258 | Antifungal activity against fluconazole-resistant Candida albicans 901 assessed as inhibition of fungal growth by checker board microdilution assay | 2022 | Journal of medicinal chemistry, 04-14, Volume: 65, Issue:7 | Species-Selective Targeting of Fungal Hsp90: Design, Synthesis, and Evaluation of Novel 4,5-Diarylisoxazole Derivatives for the Combination Treatment of Azole-Resistant Candidiasis. |
| AID472408 | Antifungal activity against Candida parapsilosis ATCC 22019 after 48 hrs by broth microdilution method | 2010 | Bioorganic & medicinal chemistry, Apr-15, Volume: 18, Issue:8 | Synthesis, anticonvulsant and antimicrobial activities of some new 2-acetylnaphthalene derivatives. |
| AID1904291 | Inhibition of Cryptococcus neoformans H99 delta5,6-desaturase assessed as upregulation of ERG24 gene expression at 2 ug/ml incubated for 24 hrs by RT-PCR analysis | 2022 | Journal of medicinal chemistry, 05-12, Volume: 65, Issue:9 | Discovery of Novel Sertraline Derivatives as Potent Anti- |
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| AID425652 | Total body clearance in human | 2009 | Journal of medicinal chemistry, Aug-13, Volume: 52, Issue:15 | Physicochemical determinants of human renal clearance. |
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| AID1413580 | Antifungal activity against fluconazole-resistant Candida albicans 100 by broth microdilution method | |||
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| AID736948 | Antimicrobial activity against Candida albicans after 16 hrs by serial dilution method | 2013 | European journal of medicinal chemistry, Apr, Volume: 62 | New pyrazole derivatives containing 1,2,4-triazoles and benzoxazoles as potent antimicrobial and analgesic agents. |
| AID1179573 | Antifungal activity against fluconazole-resistant Candida albicans by NCCLS method | 2014 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 24, Issue:15 | Synthesis and SAR study of novel anticancer and antimicrobial naphthoquinone amide derivatives. |
| AID1394705 | Antifungal activity against fluconazole-resistant Candida albicans ATCC 200955 after overnight incubation by CLSI broth microdilution method | 2018 | European journal of medicinal chemistry, Apr-25, Volume: 150 | Structure-activity relationship studies of ultra-short peptides with potent activities against fluconazole-resistant Candida albicans. |
| AID436738 | Antifungal activity against multidrug-resistant Candida albicans after 24 hrs by serial dilution method | 2009 | European journal of medicinal chemistry, Oct, Volume: 44, Issue:10 | New azoles with potent antifungal activity: design, synthesis and molecular docking. |
| AID1221963 | Transporter substrate index ratio of permeability from apical to basolateral side in human Caco2 cells at 10 uM up to 120 mins by HPLC-MC analysis in presence of 1 uM of P-gp inhibitor LY335979 | 2011 | Drug metabolism and disposition: the biological fate of chemicals, Feb, Volume: 39, Issue:2 | Attenuation of intestinal absorption by major efflux transporters: quantitative tools and strategies using a Caco-2 model. |
| AID1885964 | Antifungal activity against Cryptococcus neoformans clinical isolate 56992 assessed as fungal growth inhibition incubated for 72 hrs by broth microdilution method | |||
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| AID613749 | Antifungal activity against Aspergillus niger ATCC 16404 at 128 ug/ml by broth dilution method | 2011 | Bioorganic & medicinal chemistry letters, Aug-15, Volume: 21, Issue:16 | Novel hybrids of fluconazole and furanones: design, synthesis and antifungal activity. |
| AID394718 | Fungicidal activity against Cryptococcus neoformans H99 expressing PCTR4-2/FAS2 after 72 hrs in presence of CuSO4 | 2007 | Antimicrobial agents and chemotherapy, Oct, Volume: 51, Issue:10 | Fatty acid synthesis is essential for survival of Cryptococcus neoformans and a potential fungicidal target. |
| AID602931 | Antifungal activity against Cryptococcus neoformans BLS108 after 72 hrs by micro-broth dilution method | 2011 | European journal of medicinal chemistry, Jul, Volume: 46, Issue:7 | Design, synthesis and antifungal evaluation of 1-(2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propyl)-1H-1,2,4-triazol-5(4H)-one. |
| AID48638 | Evaluation of In vitro antifungal activity against Candida tropicalis 2.11 by broth macro dilution method | 1995 | Journal of medicinal chemistry, Sep-29, Volume: 38, Issue:20 | Synthesis and antifungal activity of new azole derivatives containing an N-acylmorpholine ring. |
| AID1719178 | Antifungal activity against fluconazole-sensitive Candida albicans B3 assessed as reduction in microbial growth | 2021 | Bioorganic & medicinal chemistry letters, 03-01, Volume: 35 | A new 1-nitro-9-aminoacridine derivative targeting yeast topoisomerase II able to overcome fluconazole-resistance. |
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| AID308607 | Antifungal activity against Cryptococcus neoformans | 2007 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 17, Issue:15 | Antifungal activity in triterpene glycosides from the sea cucumber Actinopyga lecanora. |
| AID279119 | Ratio of weight normalized daily dose in surviving candidemia patient to MIC at 24 hrs against Candida species | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Association of fluconazole area under the concentration-time curve/MIC and dose/MIC ratios with mortality in nonneutropenic patients with candidemia. |
| AID204347 | In vitro antifungal activity against Sporothrix schenck ii | 2003 | Journal of medicinal chemistry, Feb-13, Volume: 46, Issue:4 | Structure-based de novo design, synthesis, and biological evaluation of non-azole inhibitors specific for lanosterol 14alpha-demethylase of fungi. |
| AID1075995 | Antifungal activity against Candida albicans NCIM 3471 by standard agar method | 2014 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 24, Issue:6 | Synthesis, antileishmanial activity and docking study of N'-substitutedbenzylidene-2-(6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)acetohydrazides. |
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| AID568479 | Antifungal activity against Cryptococcus neoformans KCCM 50564 after 2 days by twofold broth dilution method | 2011 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 21, Issue:3 | Synthesis and antifungal activity of furo[2,3-f]quinolin-5-ols. |
| AID425122 | Antimicrobial activity against azole-resistant Candida albicans isolate CA10 assessed as growth at 0.125 ug/ml cotreated with 0.002 ug/ml calcineurin signaling inhibitor Tacrolimus after 48 hrs by microdilution checkboard technique relative to control | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | In vitro interactions between tacrolimus and azoles against Candida albicans determined by different methods. |
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| AID1911619 | Antifungal activity against Candida albicans CARG5 assessed as fungal growth inhibition by broth microdilution assay | 2022 | Journal of medicinal chemistry, 06-09, Volume: 65, Issue:11 | Development of Lipo-γ-AA Peptides as Potent Antifungal Agents. |
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| AID1473738 | Inhibition of human BSEP overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-taurocholate in presence of ATP measured after 15 to 20 mins by membrane vesicle transport assay | 2013 | Toxicological sciences : an official journal of the Society of Toxicology, Nov, Volume: 136, Issue:1 | A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. |
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| AID1352425 | Antifungal activity against Saccharomyces cerevisiae ATCC 9763 by CLSI two fold serial dilution method | 2018 | European journal of medicinal chemistry, Feb-25, Volume: 146 | Discovery of 2-aminothiazolyl berberine derivatives as effectively antibacterial agents toward clinically drug-resistant Gram-negative Acinetobacter baumanii. |
| AID1585635 | Antifungal activity against Saccharomyces cerevisiae SC XH1549 cultured in YNB media after 24 hrs by broth microdilution method | 2019 | European journal of medicinal chemistry, Jan-15, Volume: 162 | Chemical preparation, biological evaluation and 3D-QSAR of ethoxysulfuron derivatives as novel antifungal agents targeting acetohydroxyacid synthase. |
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| AID424631 | Antimicrobial activity against azole-susceptible Candida albicans isolate CA14 co-treated with calcineurin signaling inhibitor tacrolimus after 48 hrs by microdilution checkerboard technique | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | In vitro interactions between tacrolimus and azoles against Candida albicans determined by different methods. |
| AID1918375 | Antifungal activity against Candida albicans infected in mouse assessed as reduction in necrotic cell fragments in intercellular spaces of the infection region at 20 mg/kg, ip administered on days 2,4,6,8,10,12 and measured on day 14 by hematoxyin-eosin s | 2022 | Journal of medicinal chemistry, 11-10, Volume: 65, Issue:21 | Novel Aryl Alkamidazole Derivatives as Multifunctional Antifungal Inhibitors: Design, Synthesis, and Biological Evaluation. |
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| AID1904388 | Antibiofilm activity against Candida albicans CPCC40061 assessed as inhibition of bacterial metabolism activity in the biofilm measured after 24 hrs by XTT reduction assay | 2022 | European journal of medicinal chemistry, Apr-05, Volume: 233 | Design, synthesis, and evaluation of novel 3-thiophene derivatives as potent fungistatic and fungicidal reagents based on a conformational restriction strategy. |
| AID1738704 | Antifungal activity against Candida krusei AS 2.1045 measured after 24 hrs by micro-broth dilution assay | 2020 | European journal of medicinal chemistry, Jul-15, Volume: 198 | Design, synthesis, and biological evaluation of novel miconazole analogues containing selenium as potent antifungal agents. |
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| AID1272753 | Antifungal activity against Penicillium citrinum at 0.03 mol/L after 2 to 4 days by paper disc method | 2016 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 26, Issue:3 | Synthesis, antimicrobial activity of Schiff base compounds of cinnamaldehyde and amino acids. |
| AID285703 | Decrease in mortality of neonatal Wistar rat infected with Candida albicans ATCC 32354 at 10 mg/kg of body weight/day, ip for 4 days beginning 24 hrs before infection | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Neonatal coinfection model of coagulase-negative Staphylococcus (Staphylococcus epidermidis) and Candida albicans: fluconazole prophylaxis enhances survival and growth. |
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| AID1411884 | Down regulation of ERG11 gene expression in fluconazole susceptible Candida albicans ATCC 90028 at 8 ug/ml after 2 hrs by qRT PCR analysis | 2017 | MedChemComm, Dec-01, Volume: 8, Issue:12 | Synergistic antifungal effect of cyclized chalcone derivatives and fluconazole against |
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| AID535618 | Antifungal activity against Candida tropicalis T3 blood stream isolate harboring Fks1p FLTLS/PLRDP mutant protein | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | Caspofungin-resistant Candida tropicalis strains causing breakthrough fungemia in patients at high risk for hematologic malignancies. |
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| AID1295329 | Antifungal activity against Candida parapsilosis ATCC 22019 after 48 hrs by broth microdilution method | 2016 | European journal of medicinal chemistry, Jun-10, Volume: 115 | Role of disulfide linkage in action of bis(dialkylaminethiocarbonyl)disulfides as potent double-Edged microbicidal spermicide: Design, synthesis and biology. |
| AID1205751 | Antifungal activity against Cryptococcus gattii L28/02 after 72 hrs by microdilution method | 2015 | ACS medicinal chemistry letters, Mar-12, Volume: 6, Issue:3 | Synthesis of a New Peptide-Coumarin Conjugate: A Potential Agent against Cryptococcosis. |
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| AID462224 | Antifungal activity against pharmacoresistant Candida albicans AIDS68 infected in Wistar rat estrogen-dependent fungal vaginitis model assessed as fungal burden at 10 ug administered intravaginally 48 hrs after fungal infection measured on day 5 after inf | 2010 | Journal of medicinal chemistry, Mar-25, Volume: 53, Issue:6 | Identification of inhibitors of drug-resistant Candida albicans strains from a library of bicyclic peptidomimetic compounds. |
| AID1737526 | Antifungal activity against Candida albicans ATCC 76615 incubated for 48 hrs by two-fold broth dilution analysis | 2020 | European journal of medicinal chemistry, Jun-01, Volume: 195 | Design, synthesis and biological evaluation of novel 3,4-dihydro-2(1H)-quinolinone derivatives as potential chitin synthase inhibitors and antifungal agents. |
| AID1391290 | Antifungal activity against wild type fluconazole-sensitive Cryptococcus neoformans serotype A H99 at pH 7 measured over 4 days | 2018 | Bioorganic & medicinal chemistry, 05-15, Volume: 26, Issue:9 | Synthesis and biological evaluation of aminothiazoles against Histoplasma capsulatum and Cryptococcus neoformans. |
| AID1770944 | Antifungal activity against fluconazole-sensitive Candida albicans 901 assessed as fungal growth inhibition by CLSI protocol based method | 2021 | European journal of medicinal chemistry, Dec-05, Volume: 225 | Design, synthesis and evaluation of novel 5-phenylthiophene derivatives as potent fungicidal of Candida albicans and antifungal reagents of fluconazole-resistant fungi. |
| AID547617 | Antifungal activity against Candida glabrata isolate Cg6R with CgPDR1 G943S mutant | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | Microarray and molecular analyses of the azole resistance mechanism in Candida glabrata oropharyngeal isolates. |
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| AID1224559 | Antifungal activity against Trichophyton mentagrophytes 445 after 72 hrs by broth microdilution method | 2014 | European journal of medicinal chemistry, Jul-23, Volume: 82 | 1-Substituted-5-[(3,5-dinitrobenzyl)sulfanyl]-1H-tetrazoles and their isosteric analogs: A new class of selective antitubercular agents active against drug-susceptible and multidrug-resistant mycobacteria. |
| AID1671798 | Antifungal activity against Candida tropicalis assessed as inhibition of fungal growth after 24 hrs by CLSI protocol based two fold serial dilution method | 2019 | European journal of medicinal chemistry, Apr-01, Volume: 167 | Design and synthesis of aminothiazolyl norfloxacin analogues as potential antimicrobial agents and their biological evaluation. |
| AID1885977 | Antifungal activity against Cryptococcus gattii clinical isolate SCZ20031 assessed as fungal growth inhibition incubated for 72 hrs by broth microdilution method | |||
| AID1888261 | Antifungal activity against Candida tropicalis ATCC 1369 assessed as fungal growth inhibition measured after 72 hrs by CLSI protocol based liquid medium dilution method | |||
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| AID420072 | Antifungal activity against Candida glabrata after 24 hrs by broth microdilution assay | 2009 | Bioorganic & medicinal chemistry, Jun-01, Volume: 17, Issue:11 | Bulky 1,4-benzoxazine derivatives with antifungal activity. |
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| AID1762169 | Antifungal activity against Candida utilis 84 assessed as reduction in fungal growth incubated for 48 hrs by CLSI based serial microbroth dilution method | 2021 | Bioorganic & medicinal chemistry letters, 05-15, Volume: 40 | Synthesis and antifungal activity of new hybrids thiazolo[4,5-d]pyrimidines with (1H-1,2,4)triazole. |
| AID1125142 | Antifungal activity against Aspergillus niger ATCC9142 assessed as growth inhibition by agar serial dilution method | 2014 | European journal of medicinal chemistry, Apr-22, Volume: 77 | Design, synthesis & evaluation of condensed 2H-4-arylaminopyrimidines as novel antifungal agents. |
| AID386928 | Antifungal activity against Candida albicans MTCC 183 after 48 hrs by broth microdilution technique | 2008 | European journal of medicinal chemistry, Oct, Volume: 43, Issue:10 | Carbodithioic acid esters of fluoxetine, a novel class of dual-function spermicides. |
| AID1754264 | Antifungal activity against clinical strain Candida tropicalis by microplate reader assay | 2021 | Bioorganic & medicinal chemistry, 07-01, Volume: 41 | A new sulfated triterpene glycoside from the sea cucumber Colochirus quadrangularis, and evaluation of its antifungal, antitumor and immunomodulatory activities. |
| AID516309 | Antimicrobial activity against Cryptococcus gattii serotype B isolate NIH190 assessed as concentration required for heteroresistance | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Heteroresistance of Cryptococcus gattii to fluconazole. |
| AID1551291 | Antibacterial activity against Staphylococcus aureus KCTC209 assessed as reduction in bacterial cell growth incubated for 24 hrs by ELISA | 2019 | European journal of medicinal chemistry, Jun-15, Volume: 172 | Synthesis and biological evaluation of tryptophan-derived rhodanine derivatives as PTP1B inhibitors and anti-bacterial agents. |
| AID1762158 | Antifungal activity against Candida tropicalis 3019 assessed as reduction in fungal growth incubated for 24 hrs by CLSI based serial microbroth dilution method | 2021 | Bioorganic & medicinal chemistry letters, 05-15, Volume: 40 | Synthesis and antifungal activity of new hybrids thiazolo[4,5-d]pyrimidines with (1H-1,2,4)triazole. |
| AID332285 | Antimicrobial activity against Candida glabrata after 16 to 18 hrs by microbroth dilution assay | 2002 | Journal of natural products, Mar, Volume: 65, Issue:3 | (+)-7S-Hydroxyxestospongin A from the marine sponge Xestospongia sp. and absolute configuration of (+)-xestospongin D. |
| AID553536 | Drug accumulation in Saccharomyces cerevisiae ADCDR2 expressing Candida albicans CDR2 efflux pump reenergized with glucose at pH 6.0 after 60 mins by fluorescamine staining | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | Enhanced susceptibility to antifungal oligopeptides in yeast strains overexpressing ABC multidrug efflux pumps. |
| AID1551799 | Antibacterial activity against Enterococcus faecalis ATCC 29212 after 24 hrs by microdilution method | 2019 | European journal of medicinal chemistry, Jul-01, Volume: 173 | Antibacterial activity study of 1,2,4-triazole derivatives. |
| AID329036 | Antifungal activity against Candida parapsilosis ATCC 22019 at 25 ug/disc after 24 hrs by disc diffusion assay | 2008 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 18, Issue:8 | Synthesis and antimicrobial properties of monensin A esters. |
| AID436743 | Antifungal activity against Aspergillus fumigatus after 7 days by serial dilution method | 2009 | European journal of medicinal chemistry, Oct, Volume: 44, Issue:10 | New azoles with potent antifungal activity: design, synthesis and molecular docking. |
| AID453448 | Antifungal activity against Candida glabrata ATCC 90030 after 48 hrs by broth microdilution method | 2010 | Bioorganic & medicinal chemistry letters, Jan-15, Volume: 20, Issue:2 | Fluconazole analogues containing 2H-1,4-benzothiazin-3(4H)-one or 2H-1,4-benzoxazin-3(4H)-one moieties, a novel class of anti-Candida agents. |
| AID584389 | Antifungal activity against 1 day cultured Candida glabrata isolated from HSCT recipient with acute or chronic GVHD mouth after 17 days of prophylaxis by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Impact of antifungal prophylaxis on colonization and azole susceptibility of Candida species. |
| AID1416196 | Antifungal activity against Saccharomyces cerevisiae by two-fold serial dilution method | 2017 | MedChemComm, Aug-01, Volume: 8, Issue:8 | Discovery of potential antifungal triazoles: design, synthesis, biological evaluation, and preliminary antifungal mechanism exploration. |
| AID322755 | Binding affinity to human CYP51 | 2007 | Drug metabolism and disposition: the biological fate of chemicals, Mar, Volume: 35, Issue:3 | Three-dimensional quantitative structure-activity relationship analysis of human CYP51 inhibitors. |
| AID518143 | Antimicrobial activity against Cryptococcus gattii serotype B isolate RAM-002 assessed as concentration required for heteroresistance | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Heteroresistance of Cryptococcus gattii to fluconazole. |
| AID467289 | Antifungal activity against Aspergillus fumigatus by serial dilution method after 7 days | 2009 | Bioorganic & medicinal chemistry letters, Oct-15, Volume: 19, Issue:20 | Discovery of highly potent novel antifungal azoles by structure-based rational design. |
| AID549024 | Antimicrobial activity against Candida krusei LMR 39-14 infected in immunosuppressed CF-1 mouse assessed as serum 1,3-beta-D-glucan level at 40 mg/kg, ip administered once daily for 5 days measured after 5 days (Rvb= 6.66) | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Activity of anidulafungin in a murine model of Candida krusei infection: evaluation of mortality and disease burden by quantitative tissue cultures and measurement of serum (1,3)-beta-D-glucan levels. |
| AID1877832 | Antifungal activity against Candida albicans CA187 by microdilution method | 2022 | Bioorganic & medicinal chemistry letters, 02-15, Volume: 58 | Synthesis and antifungal evaluation of phenol-derived bis(indolyl)methanes combined with FLC against Candida albicans. |
| AID1157152 | Antifungal activity against Candida albicans ATCC 90028 after 48 hrs by CLSI broth microdilution method | 2014 | European journal of medicinal chemistry, Aug-18, Volume: 83 | Synthesis, biological evaluation and structure-activity correlation study of a series of imidazol-based compounds as Candida albicans inhibitors. |
| AID274922 | Cytotoxicity against LLC-PK1 cells by neutral red method | 2006 | Journal of medicinal chemistry, Dec-28, Volume: 49, Issue:26 | Synthesis, antifungal activity, and structure-activity relationships of coruscanone A analogues. |
| AID545267 | Antifungal activity against Candida albicans ATCC 44859 after 48 hrs by broth microdilution method | 2010 | European journal of medicinal chemistry, Dec, Volume: 45, Issue:12 | New amino acid esters of salicylanilides active against MDR-TB and other microbes. |
| AID1585633 | Antifungal activity against fluconazole-resistant Candida albicans isolate g5 cultured in YNB media after 48 hrs by broth microdilution method | 2019 | European journal of medicinal chemistry, Jan-15, Volume: 162 | Chemical preparation, biological evaluation and 3D-QSAR of ethoxysulfuron derivatives as novel antifungal agents targeting acetohydroxyacid synthase. |
| AID462241 | Antifungal activity against Candida albicans SA40 infected in Wistar rat estrogen-dependent fungal vaginitis model assessed as fungal burden at 10 ug administered intravaginally 24 hrs after fungal infection measured on day 2 after infection | 2010 | Journal of medicinal chemistry, Mar-25, Volume: 53, Issue:6 | Identification of inhibitors of drug-resistant Candida albicans strains from a library of bicyclic peptidomimetic compounds. |
| AID1864905 | Antifungal activity against fluconazole- resistant Candida albicans 904 assessed as fungal growth inhibition measured after 72 hrs in presence of naproxen by double dilution method | |||
| AID325036 | Antimicrobial activity against Candida albicans P5 after 24 hrs by broth macrodilution method | 2007 | Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5 | A Candida albicans petite mutant strain with uncoupled oxidative phosphorylation overexpresses MDR1 and has diminished susceptibility to fluconazole and voriconazole. |
| AID405010 | Antifungal activity against Sporothrix schenckii P0019 isolate from cutaneous-lymphatic sporotrichosis patient after 72 hrs by Sensititre YeastOne method | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | In vitro susceptibility of Sporothrix schenckii to six antifungal agents determined using three different methods. |
| AID47889 | Evaluation of In vitro antifungal activity against Candida parapsilosis C292 by broth macro dilution method | 1995 | Journal of medicinal chemistry, Sep-29, Volume: 38, Issue:20 | Synthesis and antifungal activity of new azole derivatives containing an N-acylmorpholine ring. |
| AID1556238 | Inhibition of CYP51 in Candida albicans ATCC SC5314 assessed as change in sterol components incubated for 16 hrs by GC/MS analysis | 2019 | European journal of medicinal chemistry, Sep-01, Volume: 177 | Design, synthesis, and structure-activity relationship studies of l-amino alcohol derivatives as broad-spectrum antifungal agents. |
| AID1205760 | Antifungal activity against Cryptococcus neoformans ATCC 28957 after 72 hrs by microdilution method | 2015 | ACS medicinal chemistry letters, Mar-12, Volume: 6, Issue:3 | Synthesis of a New Peptide-Coumarin Conjugate: A Potential Agent against Cryptococcosis. |
| AID588210 | Human drug-induced liver injury (DILI) modelling dataset from Ekins et al | 2010 | Drug metabolism and disposition: the biological fate of chemicals, Dec, Volume: 38, Issue:12 | A predictive ligand-based Bayesian model for human drug-induced liver injury. |
| AID1246729 | Antifungal activity against Cryptococcus gattii 196L/03 assessed as reduction in ergosterol content at MIC after 24 hrs by spectrophotometric analysis | 2015 | European journal of medicinal chemistry, Sep-18, Volume: 102 | Thiazole compounds with activity against Cryptococcus gattii and Cryptococcus neoformans in vitro. |
| AID244886 | In-vitro minimum inhibitory concentration against the growth of Sporothrix schenckii | 2005 | Bioorganic & medicinal chemistry letters, Jul-01, Volume: 15, Issue:13 | Synthesis of (1,4)-naphthoquinono-[3,2-c]-1H-pyrazoles and their (1,4)-naphthohydroquinone derivatives as antifungal, antibacterial, and anticancer agents. |
| AID644842 | Antifungal activity against Candida glabrata after 48 hrs by M27-A3 CLSI method | 2012 | European journal of medicinal chemistry, Mar, Volume: 49 | Synthesis and antifungal activity of a new series of 2-(1H-imidazol-1-yl)-1-phenylethanol derivatives. |
| AID1430405 | Antifungal activity against Candida albicans A01 after 24 to 48 hrs by macro-broth dilution method | 2017 | Bioorganic & medicinal chemistry letters, 03-01, Volume: 27, Issue:5 | Methylsulfonyl benzothiazoles (MSBT) derivatives: Search for new potential antimicrobial and anticancer agents. |
| AID1474169 | Antifungal activity against Candida albicans CPCC 400523 by broth microdilution assay | 2016 | European journal of medicinal chemistry, Nov-10, Volume: 123 | Design, synthesis, and structure-activity relationship studies of benzothiazole derivatives as antifungal agents. |
| AID351029 | Antimicrobial activity against Candida albicans ATCC 10231 by broth microdilution method | 2009 | European journal of medicinal chemistry, Mar, Volume: 44, Issue:3 | 2-Acylhydrazino-5-arylpyrrole derivatives: synthesis and antifungal activity evaluation. |
| AID1427206 | Antifungal activity against Trichosporon asahii 1188 after 24 hrs by microdilution broth assay | 2017 | Bioorganic & medicinal chemistry, 03-15, Volume: 25, Issue:6 | Antimicrobial activity of rhodanine-3-acetic acid derivatives. |
| AID405031 | Antifungal activity against Sporothrix schenckii P24223 isolate from cutaneous-lymphatic sporotrichosis patient after 72 hrs by Sensititre YeastOne method | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | In vitro susceptibility of Sporothrix schenckii to six antifungal agents determined using three different methods. |
| AID608677 | Antifungal activity against Microsporum gypseum at 500 ug/ml after 72 hrs by agar diffusion method | 2011 | European journal of medicinal chemistry, Aug, Volume: 46, Issue:8 | Synthesis, characterization and antimicrobial studies of some new pyrazole incorporated imidazole derivatives. |
| AID1357636 | Antifungal activity against Cryptococcus neoformans ATCC 24067 after 72 hrs by microbroth dilution assay | 2018 | European journal of medicinal chemistry, May-10, Volume: 151 | Synthesis, molecular modeling studies and evaluation of antifungal activity of a novel series of thiazole derivatives. |
| AID1890290 | Cytotoxicity against mouse NIH/3T3 cells assessed as reduction in cell viability at 150 ug/ml incubated for 48 hrs by MTT assay (Rvb = 93.8 +/- 4.9 %) | 2022 | Bioorganic & medicinal chemistry letters, 05-01, Volume: 63 | Novel 2-aryl-4-aryloxyquinoline-based fungistatics for Mucor circinelloides. Biological evaluation of activity, QSAR and docking study. |
| AID555003 | Antifungal activity against Candida krusei assessed as percent resistant isolates at 25 ug/disc by CLSI M44-A disk diffusion method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | In vitro activities of fluconazole and voriconazole against clinical isolates of Candida spp. determined by disk diffusion testing in Turin, Italy. |
| AID1380520 | Antifungal activity against Candida glabrata MTCC 3814 assessed as inhibition of fungal growth incubated for 48 hrs by broth microdilution assay | 2018 | Bioorganic & medicinal chemistry letters, 06-01, Volume: 28, Issue:10 | Biofilm inhibition and anti-Candida activity of a cationic lipo-benzamide molecule with twin-nonyl chain. |
| AID589647 | Antifungal activity against Aspergillus niger | 2011 | European journal of medicinal chemistry, Apr, Volume: 46, Issue:4 | Synthesis of some novel 3-(1-(1-substitutedpiperidin-4-yl)-1H-1,2,3-triazol-4-yl)-5-substituted phenyl-1,2,4-oxadiazoles as antifungal agents. |
| AID625763 | Antifungal activity against Candida albicans AT 30 ug/ml after 48 hrs by agar disk diffusion assay | 2011 | European journal of medicinal chemistry, Nov, Volume: 46, Issue:11 | L-Proline anchored multicomponent synthesis of novel pyrido[2,3-a]carbazoles; investigation of in vitro antimicrobial, antioxidant, cytotoxicity and structure activity relationship studies. |
| AID693581 | Antifungal activity against Aspergillus niger MTCC 282 after 48 hrs by tube dilution method | 2012 | European journal of medicinal chemistry, Dec, Volume: 58 | Synthesis pharmacological evaluation and docking studies of pyrimidine derivatives. |
| AID29344 | Ionisation constant (pKa) | 2002 | Journal of medicinal chemistry, Jun-20, Volume: 45, Issue:13 | Prediction of volume of distribution values in humans for neutral and basic drugs using physicochemical measurements and plasma protein binding data. |
| AID1179903 | Antimicrobial activity against Candida albicans by two-fold serial dilution technique | 2014 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 24, Issue:15 | Synthesis and bioactive evaluation of a novel series of coumarinazoles. |
| AID289661 | Antimicrobial activity against Staphylococcus aureus at 400 ug/ml after 48 hrs by disc-diffusion assay | 2007 | Bioorganic & medicinal chemistry letters, Jan-15, Volume: 17, Issue:2 | N/C-4 substituted azetidin-2-ones: synthesis and preliminary evaluation as new class of antimicrobial agents. |
| AID372236 | Effect on CDR11 RNA level in Candida albicans CHK21 at MIC after 120 mins by RT-PCR | 2007 | Antimicrobial agents and chemotherapy, Oct, Volume: 51, Issue:10 | The Ssk1p response regulator and Chk1p histidine kinase mutants of Candida albicans are hypersensitive to fluconazole and voriconazole. |
| AID1904260 | Antifungal activity against Candida glabrata 9073 assessed as inhibition of fungal growth incubated for 48 hrs by microdilution method | 2022 | Journal of medicinal chemistry, 05-12, Volume: 65, Issue:9 | Discovery of Novel Sertraline Derivatives as Potent Anti- |
| AID420066 | Antifungal activity against Candida albicans PCA-2 after 24 hrs by broth microdilution assay | 2009 | Bioorganic & medicinal chemistry, Jun-01, Volume: 17, Issue:11 | Bulky 1,4-benzoxazine derivatives with antifungal activity. |
| AID1864922 | Toxicity in mouse infected with Candida albicans assessed as BUN level in plasma at 10 ug per 20 g, ip administered on day 2, 4, 6, 8, 10 and 12 and measured on day 14 (Rvb = 8.2 +/- 0.5 mmol/L) | |||
| AID525590 | Antibacterial activity against azole-susceptible Candida albicans DSY294 by EUCAST standards based broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Genetic dissection of azole resistance mechanisms in Candida albicans and their validation in a mouse model of disseminated infection. |
| AID518180 | Antimicrobial activity against Cryptococcus gattii serotype B isolate NIH190 assessed as heteroresistant isolates at 2 ug/ml | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Heteroresistance of Cryptococcus gattii to fluconazole. |
| AID516314 | Antimicrobial activity against fluconazole-resistant Cryptococcus gattii serotype B isolate B5765 at 64 ug/ml | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Heteroresistance of Cryptococcus gattii to fluconazole. |
| AID412143 | Antifungal activity against Candida tropicalis KCCM 50662 after 1 day | 2009 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 19, Issue:1 | Synthesis and antifungal activity of 1H-pyrrolo[3,2-g]quinoline-4,9-diones and 4,9-dioxo-4,9-dihydro-1H-benzo[f]indoles. |
| AID1707514 | Effect on CDR2 mRNA expression in Candida albicans 0304103 at 32 ug/ml incubated for 24 hrs by RT-PCR analysis | 2021 | Journal of medicinal chemistry, 01-28, Volume: 64, Issue:2 | Novel Carboline Fungal Histone Deacetylase (HDAC) Inhibitors for Combinational Treatment of Azole-Resistant Candidiasis. |
| AID554726 | Inhibition of Candida krusei ABC1 expressed in Saccharomyces cerevisiae isolate ADdelta at 23 nM | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Abc1p is a multidrug efflux transporter that tips the balance in favor of innate azole resistance in Candida krusei. |
| AID1360041 | Antimicrobial activity against Candida albicans after 18 to 20 hrs by micro broth dilution method | 2018 | European journal of medicinal chemistry, Jun-25, Volume: 154 | Free radical rearrangement synthesis and microbiological evaluation of novel 2-sulfoether-4-quinolone scaffolds as potential antibacterial agents. |
| AID675310 | Antifungal activity against Candida mycoderma by two fold broth dilution method | 2012 | Bioorganic & medicinal chemistry letters, Sep-01, Volume: 22, Issue:17 | Design, synthesis and evaluation of clinafloxacin triazole hybrids as a new type of antibacterial and antifungal agents. |
| AID545275 | Antifungal activity against Trichosporon beigelii 1188 after 48 hrs by broth microdilution method | 2010 | European journal of medicinal chemistry, Dec, Volume: 45, Issue:12 | New amino acid esters of salicylanilides active against MDR-TB and other microbes. |
| AID49814 | Fungicidal versus fungistatic activity of bifunctional sphingolipids against Candida glabrata at a concentration of 1 ug/mL before dilution replating; no fungistatic growth on plate | 2002 | Bioorganic & medicinal chemistry letters, Aug-19, Volume: 12, Issue:16 | Antifungal activity of bifunctional sphingolipids. Intramolecular synergism within long-chain alpha,omega-bis-aminoalcohols. |
| AID279093 | Ratio of AUC in candidemia patient to MIC against Candida parapsilosis | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Association of fluconazole area under the concentration-time curve/MIC and dose/MIC ratios with mortality in nonneutropenic patients with candidemia. |
| AID497805 | Antifungal activity against fluconazole-resistant Candida glabrata isolate 03 by broth microdilution assay | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Assessment of the in vitro kinetic activity of caspofungin against Candida glabrata. |
| AID518162 | Antimicrobial activity against Cryptococcus gattii serotype C isolate NIH34 assessed as concentration required for heteroresistance | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Heteroresistance of Cryptococcus gattii to fluconazole. |
| AID1762167 | Antifungal activity against Microsporum canis B-200 assessed as reduction in fungal growth incubated for 48 hrs by CLSI based serial microbroth dilution method | 2021 | Bioorganic & medicinal chemistry letters, 05-15, Volume: 40 | Synthesis and antifungal activity of new hybrids thiazolo[4,5-d]pyrimidines with (1H-1,2,4)triazole. |
| AID32669 | In vitro inhibition of Absidia corymbifera 272 growth for 24 hours. | 2001 | Journal of medicinal chemistry, Aug-16, Volume: 44, Issue:17 | 3-Phenyl-5-acyloxymethyl-2H,5H-furan-2-ones: synthesis and biological activity of a novel group of potential antifungal drugs. |
| AID1601671 | Antifungal activity against planktonic form of Candida albicans ATCC 10261 by broth microdilution method | |||
| AID1674372 | Unbound AUC in human administered as single dose | 2020 | Journal of medicinal chemistry, 11-12, Volume: 63, Issue:21 | Integrating the Impact of Lipophilicity on Potency and Pharmacokinetic Parameters Enables the Use of Diverse Chemical Space during Small Molecule Drug Optimization. |
| AID1379940 | Antifungal activity against Candida parapsilosis clinical isolates assessed as inhibition of microbial growth incubated for 24 hrs by broth microdilution method | 2017 | European journal of medicinal chemistry, Nov-10, Volume: 140 | Synthesis, biological evaluation and quantitative structure-active relationships of 1,3-thiazolidin-4-one derivatives. A promising chemical scaffold endowed with high antifungal potency and low cytotoxicity. |
| AID775730 | Antifungal activity against Aspergillus niger assessed as growth inhibition after 48 to 72 hrs by broth microdilution method | 2013 | European journal of medicinal chemistry, Nov, Volume: 69 | Microwave assisted synthesis of dihydrobenzo[4,5]imidazo[1,2-a]pyrimidin-4-ones; synthesis, in vitro antimicrobial and anticancer activities of novel coumarin substituted dihydrobenzo[4,5]imidazo[1,2-a]pyrimidin-4-ones. |
| AID1419552 | Selectivity index, ratio of EC50 for toxicity in human BEAS2B cells to MIC50 for antifungal activity against ITC and FLC-resistant Candida albicans ATCC MYA-1003 | 2017 | European journal of medicinal chemistry, Jun-16, Volume: 133 | Novel alkylated azoles as potent antifungals. |
| AID294855 | Antifungal activity against Microsporum gypseum after 7 days by micro-broth dilution method | 2007 | European journal of medicinal chemistry, Sep, Volume: 42, Issue:9 | Synthesis of novel triazole derivatives as inhibitors of cytochrome P450 14alpha-demethylase (CYP51). |
| AID1067049 | Antifungal activity against Candida albicans Y0109 after 24 hrs by micro-broth dilution method | 2014 | European journal of medicinal chemistry, Mar-03, Volume: 74 | Synthesis, antifungal activities and molecular docking studies of novel 2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propyl dithiocarbamates. |
| AID581877 | Antifungal activity against Candida glabrata isolated from neutropenic subject 1491 with AML or MDS pharynx receiving antifungal drug after 23 days prophylaxis by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Impact of antifungal prophylaxis on colonization and azole susceptibility of Candida species. |
| AID1180299 | Antimicrobial activity against Candida albicans NCIM-3471 after 20 hrs by two fold serial macrodilution technique | 2014 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 24, Issue:15 | One pot three components microwave assisted and conventional synthesis of new 3-(4-chloro-2-hydroxyphenyl)-2-(substituted) thiazolidin-4-one as antimicrobial agents. |
| AID245568 | In vitro concentration required to inhibit 80% growth of Saccharomyces cerevisiae strain Y218 (CgCDR2 over-expressed) after 48 h | 2004 | Bioorganic & medicinal chemistry letters, Oct-18, Volume: 14, Issue:20 | Quinazolinone-based fungal efflux pump inhibitors. Part 1: Discovery of an (N-methylpiperazine)-containing derivative with activity in clinically relevant Candida spp. |
| AID1154872 | Antifungal activity against Candida krusei 0710397 after 7 days by serial dilution method | 2014 | ACS medicinal chemistry letters, May-08, Volume: 5, Issue:5 | Novel carboline derivatives as potent antifungal lead compounds: design, synthesis, and biological evaluation. |
| AID750288 | Antifungal activity against Candida albicans ATCC 10231 after 24 to 48 hrs by broth microdilution method | 2013 | European journal of medicinal chemistry, Jun, Volume: 64 | 2-Aminobenzothiazole derivatives: search for new antifungal agents. |
| AID1193498 | Thermodynamic equilibrium solubility, log S of the compound simulated gastric fluid at pH 1.2 at RT after 24 hrs by shake-flask method | 2015 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 25, Issue:7 | Thermodynamic equilibrium solubility measurements in simulated fluids by 96-well plate method in early drug discovery. |
| AID518422 | Antimicrobial activity against Cryptococcus gattii serotype C isolate H0058-1-2023 assessed as heteroresistant isolates at 2 ug/ml | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Heteroresistance of Cryptococcus gattii to fluconazole. |
| AID554793 | Antifungal activity against Candida albicans assessed as dose dependent percent susceptible isolates at 25 ug/disc by CLSI M44-A disk diffusion method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | In vitro activities of fluconazole and voriconazole against clinical isolates of Candida spp. determined by disk diffusion testing in Turin, Italy. |
| AID1872499 | Antifungal activity against Candida tropicalis | 2022 | European journal of medicinal chemistry, Mar-05, Volume: 231 | Synthetic approaches and structural diversity of triazolylbutanols derived from voriconazole in the antifungal drug development. |
| AID575754 | Antimicrobial activity against Aspergillus fumigatus AF293 | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10 | Expression, purification, and characterization of Aspergillus fumigatus sterol 14-alpha demethylase (CYP51) isoenzymes A and B. |
| AID1738711 | Antifungal activity against Candida albicans 901 measured after 24 hrs by micro-broth dilution assay | 2020 | European journal of medicinal chemistry, Jul-15, Volume: 198 | Design, synthesis, and biological evaluation of novel miconazole analogues containing selenium as potent antifungal agents. |
| AID1738738 | Inhibition of CYP51 in azole-resistant Candida albicans ATCC SC531 assessed as Lanosterol level at 0.03125 ug/ml incubated for 16 hrs by LC-MS analysis relative to control | 2020 | European journal of medicinal chemistry, Jul-15, Volume: 198 | Design, synthesis, and biological evaluation of novel miconazole analogues containing selenium as potent antifungal agents. |
| AID526736 | Antifungal activity against Aspergillus niger KCTC 1231 after 2 days | 2010 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 20, Issue:22 | Synthesis and antifungal activity of benzofuran-5-ols. |
| AID518457 | Antimicrobial activity against Cryptococcus gattii serotype C isolate H0058-1-2023 assessed as heteroresistant isolates at 4 ug/ml | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Heteroresistance of Cryptococcus gattii to fluconazole. |
| AID1820669 | Inhibition of CYP51 in Candida albicans SC5314 assessed as ergosterol level at 0.25 ug/ml measured after 18 hrs by GC-MS analysis (Rvb = 100%) | 2022 | European journal of medicinal chemistry, Jan-15, Volume: 228 | Design, synthesis, and biological activity evaluation of 2-(benzo[b]thiophen-2-yl)-4-phenyl-4,5-dihydrooxazole derivatives as broad-spectrum antifungal agents. |
| AID518673 | Antimicrobial activity against Cryptococcus gattii serotype C isolate NIH34 assessed as heteroresistant isolates at 8 ug/ml | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Heteroresistance of Cryptococcus gattii to fluconazole. |
| AID563132 | Antifungal activity against Candida glabrata ATCC 90030 infected in ICR mouse assessed as fungal load in kidney at 5 mg/kg/day, sc for 8 days measured on day 8 | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | T-2307 shows efficacy in a murine model of Candida glabrata infection despite in vitro trailing growth phenomena. |
| AID278380 | Antifungal activity against Candida lusitaniae 6936 by microdilution assay | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Molecular mechanism of flucytosine resistance in Candida lusitaniae: contribution of the FCY2, FCY1, and FUR1 genes to 5-fluorouracil and fluconazole cross-resistance. |
| AID495354 | Antimicrobial activity against fluconazole susceptible Candida albicans isolate 945 expressing low levels of ERG11 and UPC2 mRNA by microdilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | An A643T mutation in the transcription factor Upc2p causes constitutive ERG11 upregulation and increased fluconazole resistance in Candida albicans. |
| AID307393 | Antifungal activity against Candida albicans ATCC 36082 by broth microdilution assay | 2007 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 17, Issue:12 | Discovery of novel indazole-linked triazoles as antifungal agents. |
| AID1864891 | Antifungal activity against Candida albicans ATCC SC5314 assessed as fungal growth inhibition measured after 72 hrs in presence of naproxen by double dilution method | |||
| AID549048 | Antifungal activity against Candida albicans CA127 after 48 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | In vitro activities of retigeric acid B alone and in combination with azole antifungal agents against Candida albicans. |
| AID704464 | Antifungal activity against Candida glabrata MY 1381 after 24 hrs by NCCLS broth microdilution method | 2012 | ACS medicinal chemistry letters, Oct-11, Volume: 3, Issue:10 | Antifungal spectrum, in vivo efficacy, and structure-activity relationship of ilicicolin h. |
| AID372239 | Fungicidal activity against wild type Candida albicans CAF2-1 assessed as reduction in cell viability at 4 times MIC of SSK21/CHK21 after 24 hrs | 2007 | Antimicrobial agents and chemotherapy, Oct, Volume: 51, Issue:10 | The Ssk1p response regulator and Chk1p histidine kinase mutants of Candida albicans are hypersensitive to fluconazole and voriconazole. |
| AID486963 | Antifungal activity against Candida albicans after 48 hrs by micro broth dilution method | 2010 | European journal of medicinal chemistry, Jun, Volume: 45, Issue:6 | 'On water' assisted synthesis and biological evaluation of nitrogen and sulfur containing hetero-1,4-naphthoquinones as potent antifungal and antibacterial agents. |
| AID494225 | Antifungal activity against Aspergillus flavus after 48 hrs by agar streak dilution method | 2010 | European journal of medicinal chemistry, Aug, Volume: 45, Issue:8 | Novel 6,8-dibromo-4(3H)quinazolinone derivatives of anti-bacterial and anti-fungal activities. |
| AID1546141 | Antifungal activity against Candida mycoderma after 24 hrs | 2019 | European journal of medicinal chemistry, Dec-15, Volume: 184 | Current scenario of tetrazole hybrids for antibacterial activity. |
| AID424661 | Antimicrobial activity against azole-resistant Candida albicans isolate CA10 assessed as growth at 0.25 ug/ml co-treated with 0.031 ug/ml calcineurin signaling inhibitor tacrolimus after 48 hrs by microdilution checkboard technique relative to control | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | In vitro interactions between tacrolimus and azoles against Candida albicans determined by different methods. |
| AID352613 | Antifungal activity against Aspergillus fumigatus after 72 hrs by micro broth dilution method | 2009 | European journal of medicinal chemistry, Mar, Volume: 44, Issue:3 | 2,3-Disubstituted-1,4-naphthoquinones, 12H-benzo[b]phenothiazine-6,11-diones and related compounds: synthesis and biological evaluation as potential antiproliferative and antifungal agents. |
| AID526825 | Antifungal activity against Candida tropicalis ATCC 44508 assessed as concentration required to 80% growth inhibition using alamar blue staining after 18 to 72 hrs by microdilution method | 2010 | Bioorganic & medicinal chemistry, Nov-01, Volume: 18, Issue:21 | 1,3-Benzoxazole-4-carbonitrile as a novel antifungal scaffold of β-1,6-glucan synthesis inhibitors. |
| AID555010 | Antifungal activity against Candida intermedia assessed as percent susceptible isolates at 25 ug/disc by CLSI M44-A disk diffusion method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | In vitro activities of fluconazole and voriconazole against clinical isolates of Candida spp. determined by disk diffusion testing in Turin, Italy. |
| AID1287920 | Antifungal activity against Candida albicans NCIM-3471 by standard agar method | 2016 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 26, Issue:7 | Novel amalgamation of phthalazine-quinolines as biofilm inhibitors: One-pot synthesis, biological evaluation and in silico ADME prediction with favorable metabolic fate. |
| AID1877305 | Antibiofilm activity against FLC-resistant Candida albicans CPCC400616 assessed as assessed as inhibition of biofilm formation measured at 6 hrs by XTT reduction assay | 2022 | European journal of medicinal chemistry, Jan-05, Volume: 227 | Broadening antifungal spectrum and improving metabolic stablity based on a scaffold strategy: Design, synthesis, and evaluation of novel 4-phenyl-4,5-dihydrooxazole derivatives as potent fungistatic and fungicidal reagents. |
| AID406865 | Antimicrobial activity against Candida albicans GDH2346 dissociated biofilms at cell density of 10'8 cells/ml after 48 hrs by XTT assay | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | Role for cell density in antifungal drug resistance in Candida albicans biofilms. |
| AID1592339 | Antifungal activity against Aspergillus niger ATCC 439 measured after 72 hrs by agar dilution method | 2019 | European journal of medicinal chemistry, Apr-01, Volume: 167 | Efficient click chemistry towards novel 1H-1,2,3-triazole-tethered 4H-chromene-d-glucose conjugates: Design, synthesis and evaluation of in vitro antibacterial, MRSA and antifungal activities. |
| AID214425 | In vitro evaluation of minimum inhibitory concentration against Trichophyton rubrum 90 | 1995 | Journal of medicinal chemistry, Sep-29, Volume: 38, Issue:20 | Synthesis and antifungal activity of new azole derivatives containing an N-acylmorpholine ring. |
| AID1059362 | Antifungal activity against Candida dubliniensis after 20 hrs by agar dilution method | 2013 | European journal of medicinal chemistry, , Volume: 70 | Designing and synthesis of novel antimicrobial heterocyclic analogs of fatty acids. |
| AID1348786 | Antifungal activity against Candida glabrata ATCC 2001 after 48 hrs by broth microdilution method | 2018 | European journal of medicinal chemistry, Jan-01, Volume: 143 | Substituted carbamothioic amine-1-carbothioic thioanhydrides as novel trichomonicidal fungicides: Design, synthesis, and biology. |
| AID424649 | Antimicrobial activity against azole-resistant Candida albicans isolate CA10 assessed as growth at 0.125 ug/ml cotreated with 0.063 ug/ml calcineurin signaling inhibitor Tacrolimus after 48 hrs by microdilution checkboard technique relative to control | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | In vitro interactions between tacrolimus and azoles against Candida albicans determined by different methods. |
| AID1196783 | Inhibition of recombinant full-length Trypanosoma cruzi CYP51 assessed as molar ratio of inhibitor to enzyme which causes 2 fold decrease in enzyme activity in 1 hr by HPLC analysis | 2015 | Journal of medicinal chemistry, Feb-12, Volume: 58, Issue:3 | Novel 3-nitrotriazole-based amides and carbinols as bifunctional antichagasic agents. |
| AID549050 | Antifungal activity against Candida albicans CA10 after 48 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | In vitro activities of retigeric acid B alone and in combination with azole antifungal agents against Candida albicans. |
| AID369392 | Antimicrobial activity against Trichosporon inkin isolate | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | In vitro susceptibility to posaconazole of 1,903 yeast isolates recovered in France from 2003 to 2006 and tested by the method of the European committee on antimicrobial susceptibility testing. |
| AID420073 | Antifungal activity against Candida glabrata after 48 hrs by broth microdilution assay | 2009 | Bioorganic & medicinal chemistry, Jun-01, Volume: 17, Issue:11 | Bulky 1,4-benzoxazine derivatives with antifungal activity. |
| AID365071 | Antifungal activity against Aspergillus flavus F44 after 3 days by broth macrodilution method | 2008 | Bioorganic & medicinal chemistry, Sep-01, Volume: 16, Issue:17 | Antifungal activity of synthetic di(hetero)arylamines based on the benzo[b]thiophene moiety. |
| AID537672 | Antifungal activity against Aspergillus niger RSKK 4017 after 18 hrs by agar-well diffusion method | 2010 | European journal of medicinal chemistry, Nov, Volume: 45, Issue:11 | Cyclization of some carbothioamide derivatives containing antipyrine and triazole moieties and investigation of their antimicrobial activities. |
| AID1886051 | Synergistic antifungal activity against Cryptococcus gattii clinical isolate SCZ20024 assessed as fractional inhibitory concentration index incubated for 72 hrs in presence of P163-0892 by broth microdilution method | |||
| AID670738 | Antifungal activity against Epidermophyton MTCC 613 by spectrophotometry based assay | 2012 | Bioorganic & medicinal chemistry letters, Jul-15, Volume: 22, Issue:14 | Synthesis and evaluation of novel 3a,9a-dihydro-1-ethoxycarbonyl-1-cyclopenteno[5,4-b]benzopyran-4-ones as antifungal agents. |
| AID1239798 | Antifungal activity against Candida albicans ATCC 10231 at 10 ug/ml after 48 hrs by cup plate method | 2015 | Bioorganic & medicinal chemistry letters, Sep-01, Volume: 25, Issue:17 | Design, synthesis and evaluation of benzotriazole derivatives as novel antifungal agents. |
| AID1864885 | Antifungal activity against Candida tropicalis ATCC 1369 assessed as fungal growth inhibition measured after 72 hrs in presence of naproxen by double dilution method | |||
| AID546075 | Antifungal activity against Candida guilliermondii isolated from candidemia patient by AFST-EUCAST microdilution method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | A 10-year survey of antifungal susceptibility of candidemia isolates from intensive care unit patients in Greece. |
| AID679339 | TP_TRANSPORTER: transepithelial transport (basal to apical) in mdr1a-expressing LLC-PK1 cell | 2002 | The Journal of pharmacology and experimental therapeutics, Oct, Volume: 303, Issue:1 | Interaction of cytochrome P450 3A inhibitors with P-glycoprotein. |
| AID1309052 | Antifungal activity against Candida albicans ATCC MYA-1003 after 48 hrs by CLSI M27-A3 method | 2016 | Bioorganic & medicinal chemistry, 08-15, Volume: 24, Issue:16 | Synthesis and investigation of novel benzimidazole derivatives as antifungal agents. |
| AID405070 | Antifungal activity against Candida parapsilosis ATCC 22019 isolate from cutaneous-lymphatic sporotrichosis patient after 72 hrs by Sensititre YeastOne method | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | In vitro susceptibility of Sporothrix schenckii to six antifungal agents determined using three different methods. |
| AID49803 | Compound was tested for antifungal activity against growth of two strains Candida glabrata | 2000 | Bioorganic & medicinal chemistry letters, Apr-17, Volume: 10, Issue:8 | Synthesis and antifungal activity of a ferrocene-fluconazole analogue. |
| AID1180453 | Antimicrobial activity against Trichophyton mentagrophytes 445 after 72 hrs by microdilution method | 2014 | Bioorganic & medicinal chemistry, Aug-01, Volume: 22, Issue:15 | Synthesis and biological activity of new salicylanilide N,N-disubstituted carbamates and thiocarbamates. |
| AID245250 | Minimum inhibitory concentration to inhibit Candida albicans strain range is equal to 0.125-64 | 2004 | Journal of medicinal chemistry, Jul-29, Volume: 47, Issue:16 | Imidazole analogues of fluoxetine, a novel class of anti-Candida agents. |
| AID1187438 | Antifungal activity against Candida parapsilosis after 24 hrs by serial dilution method | 2014 | Bioorganic & medicinal chemistry letters, Sep-01, Volume: 24, Issue:17 | Scaffold hopping of sampangine: discovery of potent antifungal lead compound against Aspergillus fumigatus and Cryptococcus neoformans. |
| AID1783777 | Antifungal activity against Candida parapsilosis GIM2.190 assessed as inhibition of fungal growth by NCCLS protocol based method | 2021 | European journal of medicinal chemistry, Nov-15, Volume: 224 | Improving the metabolic stability of antifungal compounds based on a scaffold hopping strategy: Design, synthesis, and structure-activity relationship studies of dihydrooxazole derivatives. |
| AID675308 | Antibacterial activity against Bacillus proteus by two fold broth dilution method | 2012 | Bioorganic & medicinal chemistry letters, Sep-01, Volume: 22, Issue:17 | Design, synthesis and evaluation of clinafloxacin triazole hybrids as a new type of antibacterial and antifungal agents. |
| AID1300882 | Antifungal activity against Candida parapsilosis clinical isolate after 24 hrs by broth microdilution method | 2016 | European journal of medicinal chemistry, Jul-19, Volume: 117 | Novel 1,3-thiazolidin-4-one derivatives as promising anti-Candida agents endowed with anti-oxidant and chelating properties. |
| AID1415620 | Antifungal activity against fluconazole-resistant Candida tropicalis clinical isolate 087 at 1 ug/ml after 16 hrs by turbidity method | 2017 | MedChemComm, May-01, Volume: 8, Issue:5 | Synthesis and synergistic antifungal effects of monoketone derivatives of curcumin against fluconazole-resistant |
| AID547611 | Antifungal activity against Candida glabrata isolate Cg2R with CgPDR1 F575L mutant | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | Microarray and molecular analyses of the azole resistance mechanism in Candida glabrata oropharyngeal isolates. |
| AID1254323 | Antifungal activity against Trichosporon asahii 1188 after 48 hrs by microdilution broth method | 2015 | Bioorganic & medicinal chemistry, Nov-15, Volume: 23, Issue:22 | Novel derivatives of nitro-substituted salicylic acids: Synthesis, antimicrobial activity and cytotoxicity. |
| AID1494193 | Antifungal activity against Candida parapsilosis isolate CP3 measured after 48 hrs by CLSI M27-A3 protocol based method | 2018 | Bioorganic & medicinal chemistry, 02-01, Volume: 26, Issue:3 | Novel fluconazole derivatives with promising antifungal activity. |
| AID1157184 | Antifungal activity against Candida glabrata PMC 0852R after 48 hrs by CLSI broth microdilution method | 2014 | European journal of medicinal chemistry, Aug-18, Volume: 83 | Synthesis, biological evaluation and structure-activity correlation study of a series of imidazol-based compounds as Candida albicans inhibitors. |
| AID526817 | Antifungal activity against Candida krusei ATCC 44507 assessed as concentration required to 50% growth inhibition using alamar blue staining after 18 to 72 hrs by microdilution method | 2010 | Bioorganic & medicinal chemistry, Nov-01, Volume: 18, Issue:21 | 1,3-Benzoxazole-4-carbonitrile as a novel antifungal scaffold of β-1,6-glucan synthesis inhibitors. |
| AID600163 | Antifungal activity against Candida neoformans after 96 hrs | 2011 | European journal of medicinal chemistry, Jun, Volume: 46, Issue:6 | Amberlite-IRA-402 (OH) ion exchange resin mediated synthesis of indolizines, pyrrolo [1,2-a] quinolines and isoquinolines: antibacterial and antifungal evaluation of the products. |
| AID1736721 | Antifungal activity against Candida albicans ATCC 2091 assessed as reduction in fungal growth incubated for 48 hrs by broth microdilution assay | 2020 | European journal of medicinal chemistry, Mar-15, Volume: 190 | 4-Substituted picolinohydrazonamides as a new class of potential antitubercular agents. |
| AID1689214 | Antifungal activity against fluconazole-resistant Candida auris 384 assessed as reduction in fungal growth incubated for 24 hrs by CLSI based broth microdilution method | 2020 | European journal of medicinal chemistry, Mar-01, Volume: 189 | Oxadiazolylthiazoles as novel and selective antifungal agents. |
| AID545266 | Antifungal activity against Candida albicans ATCC 44859 after 24 hrs by broth microdilution method | 2010 | European journal of medicinal chemistry, Dec, Volume: 45, Issue:12 | New amino acid esters of salicylanilides active against MDR-TB and other microbes. |
| AID551056 | Antifungal activity against Candida albicans assessed as macroscopically visible colonies after 48 and 72 hrs by standard agar dilution method | 2011 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 21, Issue:1 | Microwave assisted one pot synthesis of some novel 2,5-disubstituted 1,3,4-oxadiazoles as antifungal agents. |
| AID563126 | Antifungal activity against Candida glabrata ATCC 90030 after 48 hrs by Almar blue assay in presence of 0.2% glucose | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | T-2307 shows efficacy in a murine model of Candida glabrata infection despite in vitro trailing growth phenomena. |
| AID1224547 | Antifungal activity against Candida tropicalis 156 after 24 hrs by broth microdilution method | 2014 | European journal of medicinal chemistry, Jul-23, Volume: 82 | 1-Substituted-5-[(3,5-dinitrobenzyl)sulfanyl]-1H-tetrazoles and their isosteric analogs: A new class of selective antitubercular agents active against drug-susceptible and multidrug-resistant mycobacteria. |
| AID1391313 | Antibacterial activity against methicillin-resistant Staphylococcus aureus isolate CCARM 3167 after 24 hrs by two-fold serial dilution method | 2018 | Bioorganic & medicinal chemistry letters, 05-15, Volume: 28, Issue:9 | Synthesis and evaluation of the antibacterial activities of aryl substituted dihydrotriazine derivatives. |
| AID323069 | Antifungal activity against Cryptococcus neoformans IM 042074 by micro-broth dilution method | 2008 | Bioorganic & medicinal chemistry, Jan-15, Volume: 16, Issue:2 | Antifungal and cytotoxic activities of some N-substituted aniline derivatives bearing a hetaryl fragment. |
| AID717776 | Antimicrobial activity against Candida glabrata 20/I after 48 hrs by broth microdilution test | 2012 | Bioorganic & medicinal chemistry, Dec-15, Volume: 20, Issue:24 | Contribution to investigation of antimicrobial activity of styrylquinolines. |
| AID1355708 | Antifungal activity against FLC resistant Candida albicans 100 after 48 hrs by checkerboard microdilution method | 2018 | Journal of medicinal chemistry, Jul-26, Volume: 61, Issue:14 | Discovery of Janus Kinase 2 (JAK2) and Histone Deacetylase (HDAC) Dual Inhibitors as a Novel Strategy for the Combinational Treatment of Leukemia and Invasive Fungal Infections. |
| AID516274 | Antimicrobial activity against Cryptococcus gattii serotype B isolate RB-4 assessed as concentration required for heteroresistance | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Heteroresistance of Cryptococcus gattii to fluconazole. |
| AID1556213 | Antifungal activity against fluconazole-resistant Candida albicans Strain 17# assessed as inhibition of visible microbial growth by NCCLS protocol based method | 2019 | European journal of medicinal chemistry, Sep-01, Volume: 177 | Design, synthesis, and structure-activity relationship studies of l-amino alcohol derivatives as broad-spectrum antifungal agents. |
| AID772321 | Antifungal activity against fluconazole-resistant Candida glabrata DSY530 increase expressing of CgCDR1 gene after 24 hrs by visually and spectrophotometric analysis | 2013 | ACS medicinal chemistry letters, Sep-12, Volume: 4, Issue:9 | Novel Macrocyclic Amidinoureas: Potent Non-Azole Antifungals Active against Wild-Type and Resistant Candida Species. |
| AID453727 | Antifungal activity against Candida 51 after 72 to 96 hrs by twofold serial dilution method | 2010 | Bioorganic & medicinal chemistry letters, Jan-15, Volume: 20, Issue:2 | Synthesis, spectral analysis and in vitro microbiological evaluation of 3-(3-alkyl-2,6-diarylpiperin-4-ylidene)-2-thioxoimidazolidin-4-ones as a new class of antibacterial and antifungal agents. |
| AID1609929 | Antifungal activity against Candida parapsilosis GIM 2.190 assessed as reduction in fungal growth incubated for 24 hrs by serial dilution method | |||
| AID584396 | Antifungal activity against 13 days cultured Candida krusei isolated from invasive fungal infected subject blood after 12 days of prophylaxis by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Impact of antifungal prophylaxis on colonization and azole susceptibility of Candida species. |
| AID1549155 | Inhibition of CYP51 in azole-resistant Candida albicans 0304103 assessed as unknown sterol 2 level at 0.5 ug/ml after 24 hrs by GC-MS analysis (Rvb = 6.77%) | 2020 | Journal of medicinal chemistry, 05-28, Volume: 63, Issue:10 | Discovery of Novel Fungal Lanosterol 14α-Demethylase (CYP51)/Histone Deacetylase Dual Inhibitors to Treat Azole-Resistant Candidiasis. |
| AID333839 | Antifungal activity against azole-resistant Candida albicans by broth microdilution assay | 2005 | Journal of natural products, Dec, Volume: 68, Issue:12 | Antifungal flavonoids from Hildegardia barteri. |
| AID675304 | Antibacterial activity against Micrococcus luteus ATCC 4698 by two fold broth dilution method | 2012 | Bioorganic & medicinal chemistry letters, Sep-01, Volume: 22, Issue:17 | Design, synthesis and evaluation of clinafloxacin triazole hybrids as a new type of antibacterial and antifungal agents. |
| AID425134 | Antimicrobial activity against azole-susceptible Candida albicans isolate CA14 assessed as lof reduction in colony count at 10 ug/ml cotreated with calcineurin signaling inhibitor Tacrolimus after 48 hrs by XTT assay | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | In vitro interactions between tacrolimus and azoles against Candida albicans determined by different methods. |
| AID1726242 | Antifungal activity against Candida auris CBS 12766 by CLSI standard M27 broth microdilution method | |||
| AID1754368 | Antifungal activity against Lichtheimia corymbifera CCM 8077 assessed as reduction in fungal growth incubated for 24 hrs by broth microdilution method based spectrophotometric analysis | 2021 | Bioorganic & medicinal chemistry, 07-01, Volume: 41 | Iodinated 1,2-diacylhydrazines, benzohydrazide-hydrazones and their analogues as dual antimicrobial and cytotoxic agents. |
| AID285700 | Survival of neonatal Wistar rat infected with Staphylococcus epidermidis Hay and Candida albicans ATCC 32354 at 10 mg/kg of body weight/day, ip for 4 days beginning 24 hrs before infection | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Neonatal coinfection model of coagulase-negative Staphylococcus (Staphylococcus epidermidis) and Candida albicans: fluconazole prophylaxis enhances survival and growth. |
| AID1557084 | Antifungal activity against Candida dubliniensis T-99 assessed as reduction in fungal cell growth incubated for 24 hrs by MTT based broth double dilution method | 2019 | European journal of medicinal chemistry, Oct-01, Volume: 179 | Antifungal activity, mode of action variability, and subcellular distribution of coumarin-based antifungal azoles. |
| AID1885962 | Antifungal activity against Candida parapsilosis ATCC22019 assessed as fungal growth inhibition incubated for 48 hrs by broth microdilution method | |||
| AID531464 | Antifungal activity against Candida parapsilosis assessed as susceptible dose-dependent isolates after 48 hrs by CLSI method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | In vitro susceptibilities of invasive isolates of Candida species: rapid increase in rates of fluconazole susceptible-dose dependent Candida glabrata isolates. |
| AID1198415 | Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability after 48 hrs by neutral red assay | 2015 | European journal of medicinal chemistry, Mar-26, Volume: 93 | Synthesis, QSAR and anticandidal evaluation of 1,2,3-triazoles derived from naturally bioactive scaffolds. |
| AID356367 | Antifungal activity against Candida albicans ATCC 90028 by sphingolipid reversal assay in presence of 5.0 ug/mL dihydrosphingosine | 2003 | Journal of natural products, Aug, Volume: 66, Issue:8 | Acetylenic acids inhibiting azole-resistant Candida albicans from Pentagonia gigantifolia. |
| AID1758038 | Inhibition of CYP51 in Candida albicans ATCC SC5314 assessed as lanosterol level at 0.5 ug/ml after 16 hrs by GC-MS analysis (Rvb = 1.7%) | 2021 | European journal of medicinal chemistry, Apr-15, Volume: 216 | Lead optimization generates selenium-containing miconazole CYP51 inhibitors with improved pharmacological profile for the treatment of fungal infections. |
| AID521989 | Antibacterial activity against Fluconazole resistant Candida albicans DSY3706 containing tac1delta/delta ERG11-1/ERG11-1 genotype infected in BALB/c mouse assessed as effect on infection outcome score administered intraperitoneally 1 hr post bacterial cha | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Genetic dissection of azole resistance mechanisms in Candida albicans and their validation in a mouse model of disseminated infection. |
| AID581888 | Antifungal activity against Candida albicans isolated from HSCT recipient 031 with acute or chronic GVHD mouth after 109 days prophylaxis by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Impact of antifungal prophylaxis on colonization and azole susceptibility of Candida species. |
| AID1495971 | Inhibition of Candida albicans keratinase activity at MIC incubated for 5 days under non-shaking condition and subsequent incubation for 5 days under shaking condition by UV-vis spectrophotometric analysis relative to control | 2018 | Bioorganic & medicinal chemistry, 07-23, Volume: 26, Issue:12 | Efficiency of newly prepared thiazole derivatives against some cutaneous fungi. |
| AID490319 | Antimicrobial activity against Mycobacterium phlei ATCC 10142 at 4 ug/disk by disk diffusion method | 2010 | European journal of medicinal chemistry, Jul, Volume: 45, Issue:7 | Synthesis and biological evaluation of some thio containing pyrrolo [2,3-d]pyrimidine derivatives for their anti-inflammatory and anti-microbial activities. |
| AID518683 | Antimicrobial activity against Cryptococcus gattii serotype B isolate NIH198 assessed as heteroresistant isolates at 16 ug/ml | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Heteroresistance of Cryptococcus gattii to fluconazole. |
| AID581900 | Antifungal activity against Candida glabrata isolated from HSCT recipient 497 with acute or chronic GVHD mouth after 114 days prophylaxis by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Impact of antifungal prophylaxis on colonization and azole susceptibility of Candida species. |
| AID1079932 | Highest frequency of moderate liver toxicity observed during clinical trials, expressed as a percentage. [column '% BIOL' in source] | |||
| AID1394699 | Antifungal activity against fluconazole-resistant Candida albicans ATCC 64550 after overnight incubation by CLSI broth microdilution method | 2018 | European journal of medicinal chemistry, Apr-25, Volume: 150 | Structure-activity relationship studies of ultra-short peptides with potent activities against fluconazole-resistant Candida albicans. |
| AID440315 | Anticandidal activity against Candida parapsilosis 64E after 24 hrs by spectrophotometry | 2009 | Journal of medicinal chemistry, Dec-10, Volume: 52, Issue:23 | Synthesis of new linear guanidines and macrocyclic amidinourea derivatives endowed with high antifungal activity against Candida spp. and Aspergillus spp. |
| AID480477 | Antifungal activity against Candida krusei after 24 hrs by serial dilution method | 2010 | Bioorganic & medicinal chemistry letters, May-01, Volume: 20, Issue:9 | Structure-based rational design, synthesis and antifungal activity of oxime-containing azole derivatives. |
| AID1783771 | Antifungal activity against Candida albicans SC5314 assessed as inhibition of fungal growth by NCCLS protocol based method | 2021 | European journal of medicinal chemistry, Nov-15, Volume: 224 | Improving the metabolic stability of antifungal compounds based on a scaffold hopping strategy: Design, synthesis, and structure-activity relationship studies of dihydrooxazole derivatives. |
| AID425154 | Antimicrobial activity against azole-resistant Candida albicans isolate CA10 assessed as log reduction in colony count at 10 ug/ml co-treated with calcineurin signaling inhibitor tacrolimus after 48 hrs by time killing test | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | In vitro interactions between tacrolimus and azoles against Candida albicans determined by different methods. |
| AID781086 | Antifungal activity against Aspergillus niger MTCC-281 after 24 to 72 hrs by broth dilution method | 2013 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 23, Issue:22 | Unusual transformation of substituted-3-formylchromones to pyrimidine analogues: synthesis and antimicrobial activities of 5-(o-hydroxyaroyl)pyrimidines. |
| AID1597997 | Antifungal activity against Candida tropicalis after 24 hrs by NCCLS protocol based method | 2019 | European journal of medicinal chemistry, May-15, Volume: 170 | Current advances of triazole alcohols derived from fluconazole: Design, in vitro and in silico studies. |
| AID1918350 | Induction of apoptosis in Candida albicans assessed as viable cells measured after 24 hrs by Annexin V-FITC/PI staining based flow cytometry (Rvb = 95.7%) | 2022 | Journal of medicinal chemistry, 11-10, Volume: 65, Issue:21 | Novel Aryl Alkamidazole Derivatives as Multifunctional Antifungal Inhibitors: Design, Synthesis, and Biological Evaluation. |
| AID302122 | Antifungal activity against fluconazole-resistant Candida albicans 0511655 after 24 hrs | 2007 | Journal of medicinal chemistry, Nov-01, Volume: 50, Issue:22 | Synthesis and antifungal activities of novel 2-aminotetralin derivatives. |
| AID584374 | Ratio of CDR1 gene expression in Candida glabrata isolated from patient 497 receiving antifungal drug to CDR1 gene expression in Candida glabrata isolated from patient 497 by RT-PCR analysis | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Impact of antifungal prophylaxis on colonization and azole susceptibility of Candida species. |
| AID302119 | Antifungal activity against Fonsecaea compacta | 2007 | Journal of medicinal chemistry, Nov-01, Volume: 50, Issue:22 | Synthesis and antifungal activities of novel 2-aminotetralin derivatives. |
| AID1124802 | Antifungal activity against Candida parapsilosis ATCC 299019 after 72 to 96 hrs by standard broth microdilution method | 2014 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 24, Issue:7 | Synthesis and evaluation of new diaryl ether and quinoline hybrids as potential antiplasmodial and antimicrobial agents. |
| AID1369534 | Fungicidal activity against Candida albicans 58288 after 96 hrs | 2018 | Journal of medicinal chemistry, 05-10, Volume: 61, Issue:9 | Combating Drug-Resistant Fungi with Novel Imperfectly Amphipathic Palindromic Peptides. |
| AID1822751 | Antifungal activity against fluconazole resistant Candida albicans 904 incubated for 48 hrs by CLSI based broth microdilution method | 2022 | Journal of medicinal chemistry, 02-10, Volume: 65, Issue:3 | Structure-Guided Discovery of the Novel Covalent Allosteric Site and Covalent Inhibitors of Fructose-1,6-Bisphosphate Aldolase to Overcome the Azole Resistance of |
| AID28233 | Fraction ionized (pH 7.4) | 2002 | Journal of medicinal chemistry, Jun-20, Volume: 45, Issue:13 | Prediction of volume of distribution values in humans for neutral and basic drugs using physicochemical measurements and plasma protein binding data. |
| AID453725 | Antifungal activity against Candida albicans after 72 to 96 hrs by twofold serial dilution method | 2010 | Bioorganic & medicinal chemistry letters, Jan-15, Volume: 20, Issue:2 | Synthesis, spectral analysis and in vitro microbiological evaluation of 3-(3-alkyl-2,6-diarylpiperin-4-ylidene)-2-thioxoimidazolidin-4-ones as a new class of antibacterial and antifungal agents. |
| AID1918369 | Antifungal activity against Candida albicans infected in mouse assessed as disappearance of nuclear aggregation in the infection region at 20 mg/kg, ip administered on days 2,4,6,8,10,12 and measured on day 14 by GMS staining based analysis | 2022 | Journal of medicinal chemistry, 11-10, Volume: 65, Issue:21 | Novel Aryl Alkamidazole Derivatives as Multifunctional Antifungal Inhibitors: Design, Synthesis, and Biological Evaluation. |
| AID1114816 | Antifungal activity against Candida albicans ATCC 60193 after 18 to 24 hr by double microdilution method | 2013 | Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents, Aug, Volume: 22, Issue:8 | |
| AID279106 | Mortality rate stratified by 24 hrs MIC in susceptible Candida species infected patient | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Association of fluconazole area under the concentration-time curve/MIC and dose/MIC ratios with mortality in nonneutropenic patients with candidemia. |
| AID434894 | Antifungal activity against Candida tropicalis isolate 6 in RPMI 1640 medium by broth dilution susceptibility test | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | In vitro study of Candida tropicalis isolates exhibiting paradoxical growth in the presence of high concentrations of caspofungin. |
| AID457982 | Antifungal activity against Candida parapsilosis ATCC 22019 after 48 hrs by microdilution method | 2010 | Bioorganic & medicinal chemistry, Mar-01, Volume: 18, Issue:5 | Antifungal 3,5-disubstituted furanones: From 5-acyloxymethyl to 5-alkylidene derivatives. |
| AID1595062 | In vivo antifungal activity against Candida albicans TA infected in CDF-1 mouse dosed orally assessed as survival of mouse | 2019 | European journal of medicinal chemistry, May-15, Volume: 170 | Tetrazole hybrids and their antifungal activities. |
| AID457997 | Antifungal activity against Absidia corymbifera 272 after 24 hrs by microdilution method | 2010 | Bioorganic & medicinal chemistry, Mar-01, Volume: 18, Issue:5 | Antifungal 3,5-disubstituted furanones: From 5-acyloxymethyl to 5-alkylidene derivatives. |
| AID1063951 | Antifungal activity against Candida krusei E28 after 48 hrs by broth microdilution method | 2014 | Bioorganic & medicinal chemistry, Jan-15, Volume: 22, Issue:2 | Salicylanilide diethyl phosphates: synthesis, antimicrobial activity and cytotoxicity. |
| AID1609944 | Cytotoxicity against human A549 cells assessed as cell survival at 0.08 uM/l incubated for 24 hrs by MTT assay relative to control | |||
| AID1890278 | Antifungal activity against Trichophyton mentagrophytes clinical isolate 2 assessed as reduction in fungal growth by broth dilution method | 2022 | Bioorganic & medicinal chemistry letters, 05-01, Volume: 63 | Novel 2-aryl-4-aryloxyquinoline-based fungistatics for Mucor circinelloides. Biological evaluation of activity, QSAR and docking study. |
| AID279705 | Antifungal activity against planktonic Candida albicans K1 in presence of laminarin after 48 hrs by CLSI M27 A micro-broth method | 2007 | Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2 | Putative role of beta-1,3 glucans in Candida albicans biofilm resistance. |
| AID395834 | Antimicrobial activity against Staphylococcus aureus ATCC 25923 after 24 hrs by standard microbroth dilution assay | 2009 | European journal of medicinal chemistry, Jan, Volume: 44, Issue:1 | Tetrahydronaphthyl azole oxime ethers: the conformationally rigid analogues of oxiconazole as antibacterials. |
| AID622967 | Antifungal activity against Candida krusei E28 after 24 hrs by microdilution method | 2011 | Bioorganic & medicinal chemistry letters, Oct-15, Volume: 21, Issue:20 | Synthesis and biological activity of desmethoxy analogues of coruscanone A. |
| AID304976 | Antifungal activity against Aspergillus fumigatus by broth micro-dilution technique | 2007 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 17, Issue:1 | New antifungal flavonoid glycoside from Vitex negundo. |
| AID518414 | Antimicrobial activity against Cryptococcus gattii serotype B isolate RB22 assessed as heteroresistant isolates at 2 ug/ml | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Heteroresistance of Cryptococcus gattii to fluconazole. |
| AID1427202 | Antifungal activity against Candida tropicalis 156 after 24 hrs by microdilution broth assay | 2017 | Bioorganic & medicinal chemistry, 03-15, Volume: 25, Issue:6 | Antimicrobial activity of rhodanine-3-acetic acid derivatives. |
| AID1738710 | Antifungal activity against fluconazole-resistant Candida albicans 632 measured after 24 hrs by micro-broth dilution assay | 2020 | European journal of medicinal chemistry, Jul-15, Volume: 198 | Design, synthesis, and biological evaluation of novel miconazole analogues containing selenium as potent antifungal agents. |
| AID1904396 | Cytotoxicity against mouse RAW264.7 cells assessed as reduction in cell viability incubated for 96 hrs by MTT assay | 2022 | European journal of medicinal chemistry, Apr-05, Volume: 233 | Design, synthesis, and evaluation of novel 3-thiophene derivatives as potent fungistatic and fungicidal reagents based on a conformational restriction strategy. |
| AID584393 | Antifungal activity against 1 day cultured Candida albicans isolated from HSCT recipient with acute or chronic GVHD mouth after 2 days of prophylaxis by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Impact of antifungal prophylaxis on colonization and azole susceptibility of Candida species. |
| AID1556538 | Antifungal activity against Candida albicans assessed as reduction in fungal cell viability incubated for 24 hrs by two fold serial dilution method | 2019 | European journal of medicinal chemistry, Oct-01, Volume: 179 | A new exploration towards aminothiazolquinolone oximes as potentially multi-targeting antibacterial agents: Design, synthesis and evaluation acting on microbes, DNA, HSA and topoisomerase IV. |
| AID499661 | Antimicrobial activity against Candida albicans ATCC 24433 by microdilution assay | 2010 | Bioorganic & medicinal chemistry, Aug-15, Volume: 18, Issue:16 | Novel antifungal agents: triazolopyridines as inhibitors of beta-1,6-glucan synthesis. |
| AID518148 | Antimicrobial activity against Cryptococcus gattii serotype B isolate B5763 assessed as concentration required for heteroresistance | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Heteroresistance of Cryptococcus gattii to fluconazole. |
| AID1595110 | Antifungal activity against Aspergillus flavus assessed as reduction in fungal cell growth incubated for 24 and 72 hrs by cup plate method | 2019 | European journal of medicinal chemistry, May-15, Volume: 170 | Tetrazole hybrids and their antifungal activities. |
| AID1886034 | Synergistic antifungal activity against Candida glabrata ATCC1182 assessed as fractional inhibitory concentration index incubated for 48 hrs in presence of P163-0892 by broth microdilution method | |||
| AID382543 | Antifungal activity against Aspergillus flavus SYM 223 after 48 hrs standard broth microdilution method | 2008 | European journal of medicinal chemistry, Jan, Volume: 43, Issue:1 | Synthesis, structure and biological activity of pseudopeptidic macrolides based on an amino alcohol. |
| AID521523 | Antifungal activity against Candida albicans ATCC 64550 after 47 hrs by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | In vitro and in vivo antifungal activities of T-2307, a novel arylamidine. |
| AID1820671 | Inhibition of CYP51 in Candida albicans SC5314 assessed as 140-methy lergosta-8,24(28)-dien-3(3,60-diol (4) level at 0.25 ug/ml measured after 18 hrs by GC-MS analysis | 2022 | European journal of medicinal chemistry, Jan-15, Volume: 228 | Design, synthesis, and biological activity evaluation of 2-(benzo[b]thiophen-2-yl)-4-phenyl-4,5-dihydrooxazole derivatives as broad-spectrum antifungal agents. |
| AID518675 | Antimicrobial activity against Cryptococcus gattii serotype C isolate H0058-1-78 assessed as heteroresistant isolates at 8 ug/ml | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Heteroresistance of Cryptococcus gattii to fluconazole. |
| AID154276 | In vitro inhibition of cytochrome P450 lanosterol C14 demethylase in Candida albicans CY1005 (experiment 2) | 1998 | Bioorganic & medicinal chemistry letters, Jul-21, Volume: 8, Issue:14 | Modeling, synthesis and biological activity of novel antifungal agents (1). |
| AID1861416 | Antifungal activity against fluconazole-resistant Candida albicans ATCC10231FR assessed as inhibition of fungal growth by microdilution method | 2022 | Bioorganic & medicinal chemistry letters, 09-01, Volume: 71 | Discovery of novel indole and indoline derivatives against Candida albicans as potent antifungal agents. |
| AID1369480 | Antifungal activity against Candida albicans cgmcc 2.2086 in presence of MgCl2 by broth dilution method | 2018 | Journal of medicinal chemistry, 05-10, Volume: 61, Issue:9 | Combating Drug-Resistant Fungi with Novel Imperfectly Amphipathic Palindromic Peptides. |
| AID1759065 | Antifungal activity against Aspergillus flavus | 2021 | Bioorganic & medicinal chemistry letters, 06-01, Volume: 41 | Microwave assisted regioselective synthesis of quinoline appended triazoles as potent anti-tubercular and antifungal agents via copper (I) catalyzed cycloaddition. |
| AID392360 | Antifungal activity against Candida albicans ATCC 44859 after 24 hrs by broth microdilution method | 2009 | Bioorganic & medicinal chemistry letters, Jan-15, Volume: 19, Issue:2 | Salicylanilide esters of N-protected amino acids as novel antimicrobial agents. |
| AID1738747 | Inhibition of CYP51 in azole-resistant Candida albicans ATCC SC531 assessed as Eburicol level at 8 ug/ml incubated for 16 hrs by LC-MS analysis relative to control | 2020 | European journal of medicinal chemistry, Jul-15, Volume: 198 | Design, synthesis, and biological evaluation of novel miconazole analogues containing selenium as potent antifungal agents. |
| AID1598037 | Antifungal activity against fluconalzole-susceptible Candida parapsilosis after 24 hrs | 2019 | European journal of medicinal chemistry, May-15, Volume: 170 | Current advances of triazole alcohols derived from fluconazole: Design, in vitro and in silico studies. |
| AID1595090 | Antifungal activity against Candida albicans assessed as inhibition zone at 100 ug/ml | 2019 | European journal of medicinal chemistry, May-15, Volume: 170 | Tetrazole hybrids and their antifungal activities. |
| AID382542 | Antifungal activity against Aspergillus niger ATCC 16404 after 48 hrs standard broth microdilution method | 2008 | European journal of medicinal chemistry, Jan, Volume: 43, Issue:1 | Synthesis, structure and biological activity of pseudopeptidic macrolides based on an amino alcohol. |
| AID1279021 | Antifungal activity against Candida albicans ATCC 44859 after 24 hrs by microbroth dilution method | 2016 | Bioorganic & medicinal chemistry, Mar-15, Volume: 24, Issue:6 | Salicylanilide N-monosubstituted carbamates: Synthesis and in vitro antimicrobial activity. |
| AID1885956 | Antifungal activity against Cryptococcus gattii WM178 assessed as fungal growth inhibition incubated for 72 hrs by broth microdilution method | |||
| AID546076 | Antifungal activity against Candida rugosa isolated from candidemia patient by AFST-EUCAST microdilution method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | A 10-year survey of antifungal susceptibility of candidemia isolates from intensive care unit patients in Greece. |
| AID516307 | Antimicrobial activity against Cryptococcus gattii serotype B isolate NIH254 assessed as concentration required for heteroresistance | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Heteroresistance of Cryptococcus gattii to fluconazole. |
| AID464676 | Antifungal activity against Penicillium chrysogenum after 48 to 72 hrs by broth microdilution method | 2010 | European journal of medicinal chemistry, Mar, Volume: 45, Issue:3 | Synthesis and antimicrobial studies on novel sulfonamides containing 4-azidomethyl coumarin. |
| AID1392809 | Antifungal activity against Cryptococcus neoformans cgmcc 2.3161 after 72 hrs by serial dilution method | 2018 | Bioorganic & medicinal chemistry, 07-23, Volume: 26, Issue:12 | Design, synthesis and evaluation of benzoheterocycle analogues as potent antifungal agents targeting CYP51. |
| AID670552 | Antifungal activity against Candida glabrata MTCC 3019 after 24 hrs by well diffusion method | 2012 | Bioorganic & medicinal chemistry letters, Jul-15, Volume: 22, Issue:14 | Total synthesis and antifungal activity of (2S,3R)-2-aminododecan-3-ol. |
| AID396117 | Antifungal activity against Candida albicans NCIM No. 3100 by serial dilution method | 2008 | European journal of medicinal chemistry, Dec, Volume: 43, Issue:12 | Synthesis and antimicrobial activities of a new series of 4-S-[4(1)-amino-5(1)-oxo-6(1)-substituted benzyl-4(1),5(1)-dihydro-1(1),2(1),4(1)-triazin-3-yl]mercaptoacetyl-3-arylsydnones. |
| AID582785 | Antifungal activity against Candida albicans isolate 14 assessed as lanosterol/obtusifoliol content in total sterol composition at 0.5 times MIC by GC-MS analysis | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | Identification and characterization of four azole-resistant erg3 mutants of Candida albicans. |
| AID584372 | Ratio of ERG11 gene expression in Candida glabrata isolated from patient 002 receiving antifungal drug to ERG11 gene expression in Candida glabrata isolated from patient 002 by RT-PCR analysis | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Impact of antifungal prophylaxis on colonization and azole susceptibility of Candida species. |
| AID518671 | Antimicrobial activity against Cryptococcus gattii serotype B isolate VPB572-058 assessed as heteroresistant isolates at 8 ug/ml | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Heteroresistance of Cryptococcus gattii to fluconazole. |
| AID594944 | Antimicrobial activity against Candida parapsilosis after 24 hrs by NCCLS method | 2011 | European journal of medicinal chemistry, May, Volume: 46, Issue:5 | Design and synthesis of antifungal benzoheterocyclic derivatives by scaffold hopping. |
| AID1770932 | Fungicidal activity against Candida albicans ATCC SC5314 assessed as inhibition of visible fungal growth measured after 48 hrs | 2021 | European journal of medicinal chemistry, Dec-05, Volume: 225 | Design, synthesis and evaluation of novel 5-phenylthiophene derivatives as potent fungicidal of Candida albicans and antifungal reagents of fluconazole-resistant fungi. |
| AID1326657 | Antifungal activity against Candida albicans ATCC 76615 measured after 24 hrs by two-fold serial dilution method | 2016 | European journal of medicinal chemistry, Oct-21, Volume: 122 | Design, synthesis and biological evaluation of berberine-benzimidazole hybrids as new type of potentially DNA-targeting antimicrobial agents. |
| AID495351 | Antimicrobial activity against fluconazole susceptible Candida albicans isolate 1002 expressing low levels of ERG11 and UPC2 mRNA by microdilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | An A643T mutation in the transcription factor Upc2p causes constitutive ERG11 upregulation and increased fluconazole resistance in Candida albicans. |
| AID1551844 | Antifungal activity against Aspergillus fumigatus assessed as zone of inhibition at 100 ug/ml | 2019 | European journal of medicinal chemistry, Jul-15, Volume: 174 | 1,2,4-Triazole-quinoline/quinolone hybrids as potential anti-bacterial agents. |
| AID1658342 | Antifungal activity against fluconazole-resistant Candida albicans 632 assessed as reduction in fungal growth by NCCLS method | 2020 | ACS medicinal chemistry letters, Jun-11, Volume: 11, Issue:6 | Construction and Evaluation of Molecular Models: Guide and Design of Novel SE Inhibitors. |
| AID554993 | Antifungal activity against Candida glabrata assessed as percent susceptible isolates at 25 ug/disc by CLSI M44-A disk diffusion method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | In vitro activities of fluconazole and voriconazole against clinical isolates of Candida spp. determined by disk diffusion testing in Turin, Italy. |
| AID1754364 | Antifungal activity against Candida krusei ATCC 6258 assessed as reduction in fungal growth incubated for 24 hrs by broth microdilution method based spectrophotometric analysis | 2021 | Bioorganic & medicinal chemistry, 07-01, Volume: 41 | Iodinated 1,2-diacylhydrazines, benzohydrazide-hydrazones and their analogues as dual antimicrobial and cytotoxic agents. |
| AID521528 | Antifungal activity against Candida albicans ATCC MYA-1003 after 47 hrs by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | In vitro and in vivo antifungal activities of T-2307, a novel arylamidine. |
| AID424912 | Antimicrobial activity against azole-resistant Candida albicans isolate CA10 assessed as growth at 0.5 ug/ml cotreated with 0.004 ug/ml calcineurin signaling inhibitor tacrolimus after 48 hrs by microdilution checkerboard technique relative to control | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | In vitro interactions between tacrolimus and azoles against Candida albicans determined by different methods. |
| AID425133 | Antimicrobial activity against azole-susceptible Candida albicans isolate CA14 assessed as log reduction in colony count at 10 ug/ml co-treated with calcineurin signaling inhibitor tacrolimus after 48 hrs by time killing test | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | In vitro interactions between tacrolimus and azoles against Candida albicans determined by different methods. |
| AID1157153 | Antifungal activity against Candida albicans ATCC 20891 after 48 hrs by CLSI broth microdilution method | 2014 | European journal of medicinal chemistry, Aug-18, Volume: 83 | Synthesis, biological evaluation and structure-activity correlation study of a series of imidazol-based compounds as Candida albicans inhibitors. |
| AID1543301 | Antimicrobial activity against Candida albicans ATCC 90028 assessed as inhibition of microbial growth by CLSI based method | 2019 | Journal of natural products, 07-26, Volume: 82, Issue:7 | Anthraquinone-Based Specialized Metabolites from Rhizomes of |
| AID1235490 | Inhibition of ergosterol biosynthesis in Candida tropicalis 2029 assessed as ergosterol content after 16 hrs by spectrophotometer analysis | 2015 | Bioorganic & medicinal chemistry, Aug-01, Volume: 23, Issue:15 | Imidazole clubbed 1,3,4-oxadiazole derivatives as potential antifungal agents. |
| AID469168 | Antifungal activity against Cryptococcus neoformans at MIC after 72 hrs by disk diffusion assay | 2010 | European journal of medicinal chemistry, Feb, Volume: 45, Issue:2 | Synthesis, anti-bacterial and anti-fungal activities of some novel Schiff bases containing 2,4-disubstituted thiazole ring. |
| AID1557080 | Antifungal activity against Candida glabrata 192 assessed as reduction in fungal cell growth incubated for 24 hrs by MTT based broth double dilution method | 2019 | European journal of medicinal chemistry, Oct-01, Volume: 179 | Antifungal activity, mode of action variability, and subcellular distribution of coumarin-based antifungal azoles. |
| AID532569 | Antifungal activity against Candida glabrata isolate 21230 with silent mutation in ERG4, ERG5 genes and nonsense mutation in ERG6 gene by Etest method | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | A nonsense mutation in the ERG6 gene leads to reduced susceptibility to polyenes in a clinical isolate of Candida glabrata. |
| AID619174 | Antifungal activity against Candida albicans CA20 by broth dilution method | 2011 | Journal of medicinal chemistry, Oct-13, Volume: 54, Issue:19 | High-throughput-screening-based identification and structure-activity relationship characterization defined (S)-2-(1-aminoisobutyl)-1-(3-chlorobenzyl)benzimidazole as a highly antimycotic agent nontoxic to cell lines. |
| AID341584 | Antimicrobial activity against 9 x 10'6 CFU Cryptococcus neoformans USC1597 isolate intracranially infected in Hartley guinea pig assessed as kidney bacterial count per gram at 10 mg/kg, po BID administered 48 hrs postinfection for 13 days | 2007 | Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8 | New guinea pig model of Cryptococcal meningitis. |
| AID119039 | The compound was tested in vivo for anti-candida activity in mice model 1 (dose:1.0mg/kg, fluconazole-treated group) | 1998 | Journal of medicinal chemistry, May-21, Volume: 41, Issue:11 | New azole antifungals. 3. Synthesis and antifungal activity of 3-substituted-4(3H)-quinazolinones. |
| AID554725 | Fold resistant, ratio of MIC for Saccharomyces cerevisiae isolate ADdelta overexpressing Candida krusei ERG11g to MIC for Saccharomyces cerevisiae isolate ADdelta overexpressing Abc1p | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Abc1p is a multidrug efflux transporter that tips the balance in favor of innate azole resistance in Candida krusei. |
| AID1071690 | Antifungal activity against Candida parapsilosis ATCC 22019 assessed as growth inhibition by microdliution method | 2014 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 24, Issue:5 | Antifungal ether diglycosides from Matayba guianensis Aublet. |
| AID554723 | Fold resistant, ratio of MIC for Saccharomyces cerevisiae isolate ADdelta overexpressing Candida albicans ERG11A to MIC for Saccharomyces cerevisiae isolate ADdelta overexpressing Abc1p | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Abc1p is a multidrug efflux transporter that tips the balance in favor of innate azole resistance in Candida krusei. |
| AID518451 | Antimicrobial activity against Cryptococcus gattii serotype B isolate VPB572-058 assessed as heteroresistant isolates at 4 ug/ml | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Heteroresistance of Cryptococcus gattii to fluconazole. |
| AID522129 | Antimicrobial activity against wild type Candida glabrata TG11 by colorimetric microdilution method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Roles of calcineurin and Crz1 in antifungal susceptibility and virulence of Candida glabrata. |
| AID1864957 | Antiinflammatory activity in mouse infected with Candida albicans ATCC SC5314 assessed as reduction in MMP-9 expression in spleen in presence of naproxen by hematoxylin staining based inverted microscopic analysis | |||
| AID619412 | Antifungal activity against Aspergillus flavus assessed as inhibition of mycelial growth at 4 mg/ml after 7 days | 2011 | European journal of medicinal chemistry, Oct, Volume: 46, Issue:10 | Synthesis and biological evaluation of dihydroindeno and indeno [1,2-e] [1,2,4]triazolo [3,4-b] [1,3,4]thiadiazines as antimicrobial agents. |
| AID655722 | Antifungal activity against Aspergillus niger MTCC 1108 after 48 hrs by poison food method | 2012 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 22, Issue:8 | Design, synthesis, synergistic antimicrobial activity and cytotoxicity of 4-aryl substituted 3,4-dihydropyrimidinones of curcumin. |
| AID1689220 | Antifungal activity against Candida krusei ATCC 34135 assessed as reduction in fungal growth incubated for 24 hrs by CLSI based broth microdilution method | 2020 | European journal of medicinal chemistry, Mar-01, Volume: 189 | Oxadiazolylthiazoles as novel and selective antifungal agents. |
| AID1602399 | Antifungal activity against Cryptococcus neoformans H99 assessed as up-regulation of CDK1 expression at 2 to 4 ug/ml after 24 hrs by Western blot analysis | 2019 | Journal of medicinal chemistry, 03-14, Volume: 62, Issue:5 | Discovery of Carboline Derivatives as Potent Antifungal Agents for the Treatment of Cryptococcal Meningitis. |
| AID388087 | Antibacterial activity at Staphylococcus aureus | 2008 | Bioorganic & medicinal chemistry letters, Oct-15, Volume: 18, Issue:20 | Synthesis of chimeric tetrapeptide-linked cholic acid derivatives: impending synergistic agents. |
| AID419076 | Antifungal activity against Aspergillus fumigatus SANK 10569 | 2009 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 19, Issue:7 | Amide analogs of antifungal dioxane-triazole derivatives: synthesis and in vitro activities. |
| AID554992 | Antifungal activity against Candida albicans assessed as percent resistant isolates at 25 ug/disc by CLSI M44-A disk diffusion method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | In vitro activities of fluconazole and voriconazole against clinical isolates of Candida spp. determined by disk diffusion testing in Turin, Italy. |
| AID348336 | Antifungal activity against Trichophyton mentagrophytes after 120 hrs | 2008 | European journal of medicinal chemistry, May, Volume: 43, Issue:5 | Synthesis and antimycobacterial evaluation of substituted pyrazinecarboxamides. |
| AID1394700 | Retention time of the compound at 0.4 mM by HPLC analysis | 2018 | European journal of medicinal chemistry, Apr-25, Volume: 150 | Structure-activity relationship studies of ultra-short peptides with potent activities against fluconazole-resistant Candida albicans. |
| AID1758030 | Inhibition of CYP51 in Candida albicans ATCC SC5314 assessed as ergosterol level at 8 ug/ml after 16 hrs by GC-MS analysis (Rvb = 98.3%) | 2021 | European journal of medicinal chemistry, Apr-15, Volume: 216 | Lead optimization generates selenium-containing miconazole CYP51 inhibitors with improved pharmacological profile for the treatment of fungal infections. |
| AID352587 | Antimicrobial activity against Candida albicans ATCC 60193 at 5 ug after 18 hrs by agar-well diffusion method | 2009 | European journal of medicinal chemistry, Mar, Volume: 44, Issue:3 | Synthesis of some new 1,2,4-triazoles, their Mannich and Schiff bases and evaluation of their antimicrobial activities. |
| AID283223 | Prolongation of survival in CD1 mouse infected with Coccidioides immitis Silveira administered after 3 days of infection at 10 mg/kg, po bid after 12 days relative to control | 2007 | Antimicrobial agents and chemotherapy, Mar, Volume: 51, Issue:3 | Comparison of itraconazole and fluconazole treatments in a murine model of coccidioidal meningitis. |
| AID293882 | Antifungal activity against Candida albicans CMAH 0572 after 48 to 72 hrs by broth microdilution method | 2007 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 17, Issue:6 | Synthesis of pseudopeptides based L-tryptophan as a potential antimicrobial agent. |
| AID340958 | Antifungal activity against Candida norvegensis isolates from grapes by NCCLS M27-A2 method | 2007 | Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8 | Cross-resistance to medical and agricultural azole drugs in yeasts from the oropharynx of human immunodeficiency virus patients and from environmental Bavarian vine grapes. |
| AID1419528 | Effect on sterol composition in Candida albicans ATCC 64124 assessed as ergosterol level at 0.125 ug/mL incubated for 10 mins by LC-MS analysis (Rvb = 54.72%) | 2017 | European journal of medicinal chemistry, Jun-16, Volume: 133 | Novel alkylated azoles as potent antifungals. |
| AID405021 | Antifungal activity against Sporothrix schenckii P30019 isolate from cutaneous-lymphatic sporotrichosis patient after 72 hrs by modified NCCLS M38-A method | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | In vitro susceptibility of Sporothrix schenckii to six antifungal agents determined using three different methods. |
| AID332283 | Antimicrobial activity against fluconazole-resistant Candida albicans ATCC 14503 after 16 to 18 hrs by microbroth dilution assay | 2002 | Journal of natural products, Mar, Volume: 65, Issue:3 | (+)-7S-Hydroxyxestospongin A from the marine sponge Xestospongia sp. and absolute configuration of (+)-xestospongin D. |
| AID1484688 | Antileishmanial activity against Leishmania amazonensis LV78 promastigotes forms after 8 days | 2017 | European journal of medicinal chemistry, Jul-28, Volume: 135 | An overview of azoles targeting sterol 14α-demethylase for antileishmanial therapy. |
| AID518172 | Antimicrobial activity against Cryptococcus gattii serotype B isolate NIH754 assessed as heteroresistant isolates at 2 ug/ml | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Heteroresistance of Cryptococcus gattii to fluconazole. |
| AID642936 | Antifungal activity against Candida albicans ATCC 60193 at 160 ug/ml | 2011 | ACS medicinal chemistry letters, May-12, Volume: 2, Issue:5 | Natural Product Based 6-Hydroxy-2,3,4,6-tetrahydropyrrolo[1,2-a]pyrimidinium Scaffold as A New Antifungal Template. |
| AID565551 | Antifungal activity against Rhizopus microsporus IHEM 15210 by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Correlation of in vitro activity, serum levels, and in vivo efficacy of posaconazole against Rhizopus microsporus in a murine disseminated infection. |
| AID1754262 | Antifungal activity against Candida albicans ATCC 76615 by microplate reader assay | 2021 | Bioorganic & medicinal chemistry, 07-01, Volume: 41 | A new sulfated triterpene glycoside from the sea cucumber Colochirus quadrangularis, and evaluation of its antifungal, antitumor and immunomodulatory activities. |
| AID1061242 | Antimicrobial activity against Candida albicans at 1 mg/ml by well plate method | 2014 | European journal of medicinal chemistry, Jan, Volume: 71 | Synthesis and biological evaluation of novel substituted 1,3,4-thiadiazole and 2,6-di aryl substituted imidazo [2,1-b] [1,3,4] thiadiazole derivatives. |
| AID531250 | Antifungal activity against Candida parapsilosis assessed as resistant isolates after 48 hrs by CLSI method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | In vitro susceptibilities of invasive isolates of Candida species: rapid increase in rates of fluconazole susceptible-dose dependent Candida glabrata isolates. |
| AID1374424 | Antifungal activity against Candida parapsilosis ATCC 22019 after 48 hrs by microdilution broth method | 2018 | Bioorganic & medicinal chemistry letters, 03-01, Volume: 28, Issue:5 | Synthesis, antimicrobial activity and acid dissociation constants of methyl 5,5-diphenyl-1-(thiazol-2-yl)pyrrolidine-2-carboxylate derivatives. |
| AID375813 | Antifungal activity against Candida albicans NCIM 3471 by agar plate assay | 2009 | Bioorganic & medicinal chemistry letters, Jul-01, Volume: 19, Issue:13 | Synthesis of novel 3-(1-(1-substituted piperidin-4-yl)-1H-1,2,3-triazol-4-yl)-1,2,4-oxadiazol-5(4H)-one as antifungal agents. |
| AID775472 | Fungicidal activity against Candida albicans ATCC 10231 after 18 to 24 hrs | 2013 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 23, Issue:21 | Synthesis and antimicrobial activity of polyhalobenzonitrile quinazolin-4(3H)-one derivatives. |
| AID425144 | Antimicrobial activity against azole-resistant Candida albicans isolate CA10 assessed as growth at 16 ug/ml after 48 hrs by microdilution checkerboard technique relative to control | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | In vitro interactions between tacrolimus and azoles against Candida albicans determined by different methods. |
| AID518664 | Antimicrobial activity against Cryptococcus gattii serotype B isolate B5788 assessed as heteroresistant isolates at 8 ug/ml | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Heteroresistance of Cryptococcus gattii to fluconazole. |
| AID584417 | Antifungal activity against 12 days cultured Candida glabrata isolated from HSCT recipient with acute or chronic GVHD mouth receiving antifungal therapy for 143 days after 116 days of prophylaxis by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Impact of antifungal prophylaxis on colonization and azole susceptibility of Candida species. |
| AID1067048 | Antifungal activity against Candida albicans SC5314 after 24 hrs by micro-broth dilution method | 2014 | European journal of medicinal chemistry, Mar-03, Volume: 74 | Synthesis, antifungal activities and molecular docking studies of novel 2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propyl dithiocarbamates. |
| AID293894 | Antimicrobial activity against Saccharomyces cerevisiae after 48 to 72 hrs by broth microdilution method | 2007 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 17, Issue:6 | Synthesis of pseudopeptides based L-tryptophan as a potential antimicrobial agent. |
| AID1359818 | Antifungal activity against Cryptococcus neoformans ATCC 32719 measured after 24 hrs | |||
| AID467909 | Cytotoxicity against human HeLa cells at 200 ug/ml after 24 hrs by MTT assay | 2010 | European journal of medicinal chemistry, Feb, Volume: 45, Issue:2 | Imidazole derivatives as possible microbicides with dual protection. |
| AID310101 | Antifungal activity against Penicillium marneffei by disc diffusion method | 2007 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 17, Issue:22 | Synthesis and antimicrobial activity of some novel nucleoside analogues of adenosine and 1,3-dideazaadenosine. |
| AID352609 | Antifungal activity against Candida albicans after 48 hrs by micro broth dilution method | 2009 | European journal of medicinal chemistry, Mar, Volume: 44, Issue:3 | 2,3-Disubstituted-1,4-naphthoquinones, 12H-benzo[b]phenothiazine-6,11-diones and related compounds: synthesis and biological evaluation as potential antiproliferative and antifungal agents. |
| AID766650 | Antifungal activity against Candida albicans MTCC 854 after 24 hrs by well diffusion method | 2013 | European journal of medicinal chemistry, Sep, Volume: 67 | Total synthesis and biological evaluation of clavaminol-G and its analogs. |
| AID1609928 | Antifungal activity against Candida glabrata assessed as reduction in fungal growth incubated for 24 hrs by serial dilution method | |||
| AID1061241 | Antimicrobial activity against Candida albicans at 0.5 mg/ml by well plate method | 2014 | European journal of medicinal chemistry, Jan, Volume: 71 | Synthesis and biological evaluation of novel substituted 1,3,4-thiadiazole and 2,6-di aryl substituted imidazo [2,1-b] [1,3,4] thiadiazole derivatives. |
| AID1238921 | Antifungal activity against Candida krusei WTBF-51 by microbroth dilution method | 2015 | Bioorganic & medicinal chemistry, Sep-01, Volume: 23, Issue:17 | Synthesis and antifungal evaluation of head-to-head and head-to-tail bisamidine compounds. |
| AID405035 | Antifungal activity against Sporothrix schenckii PSCC1 isolate from cutaneous-lymphatic sporotrichosis patient after 72 hrs by ATB Fungus 2 method | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | In vitro susceptibility of Sporothrix schenckii to six antifungal agents determined using three different methods. |
| AID1491254 | Inhibition of CYP51 in Candida albicans ATCC SC5314 assessed as ergosterol content at 2 ug/ml by GS-MS analysis relative to total sterols (Rvb = 98.7%) | 2017 | European journal of medicinal chemistry, Sep-08, Volume: 137 | Design, synthesis and evaluation of aromatic heterocyclic derivatives as potent antifungal agents. |
| AID143931 | In vitro inhibitory activity against Candida albicans Nmt (CaNmt) using substrate peptide GLTISKLFR-R-NH2 (0.5 uM) and myristoyl-CoA (0.5 uM); Not tested | 2003 | Bioorganic & medicinal chemistry letters, Jan-06, Volume: 13, Issue:1 | Design and synthesis of novel benzofurans as a new class of antifungal agents targeting fungal N-myristoyltransferase. Part 3. |
| AID1864880 | Antifungal activity against Candida tropicalis ATCC 1369 assessed as fungal growth inhibition measured after 72 hrs by double dilution method | |||
| AID1864962 | Immunostimulatory activity in mouse infected with Candida albicans ATCC SC5314 assessed as increase in CD8+ expression level in spleen by immunohistochemical analysis | |||
| AID1877317 | Cytotoxicity against human HepG2 cells assessed as inhibition of cell growth incubated for 4 hrs by MTT assay | 2022 | European journal of medicinal chemistry, Jan-05, Volume: 227 | Broadening antifungal spectrum and improving metabolic stablity based on a scaffold strategy: Design, synthesis, and evaluation of novel 4-phenyl-4,5-dihydrooxazole derivatives as potent fungistatic and fungicidal reagents. |
| AID425132 | Antimicrobial activity against azole-resistant Candida albicans isolate CA10 assessed as growth at 128 ug/ml cotreated with 0.002 ug/ml calcineurin signaling inhibitor Tacrolimus after 48 hrs by microdilution checkboard technique relative to control | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | In vitro interactions between tacrolimus and azoles against Candida albicans determined by different methods. |
| AID551057 | Antifungal activity against Fusarium oxysporum assessed as macroscopically visible colonies after 48 and 72 hrs by standard agar dilution method | 2011 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 21, Issue:1 | Microwave assisted one pot synthesis of some novel 2,5-disubstituted 1,3,4-oxadiazoles as antifungal agents. |
| AID544879 | Antimicrobial activity against Candida dubliniensis harboring MRR1 CD57A mutant gene by microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | Gain-of-function mutations in the transcription factor MRR1 are responsible for overexpression of the MDR1 efflux pump in fluconazole-resistant Candida dubliniensis strains. |
| AID1585628 | Antifungal activity against Candida albicans SC5314 cultured in YNB media after 72 hrs by broth microdilution method | 2019 | European journal of medicinal chemistry, Jan-15, Volume: 162 | Chemical preparation, biological evaluation and 3D-QSAR of ethoxysulfuron derivatives as novel antifungal agents targeting acetohydroxyacid synthase. |
| AID516302 | Antimicrobial activity against Cryptococcus gattii serotype B isolate NIH409 assessed as concentration required for heteroresistance | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Heteroresistance of Cryptococcus gattii to fluconazole. |
| AID351034 | Antimicrobial activity against Candida glabrata after 72 hrs by broth microdilution method | 2009 | European journal of medicinal chemistry, Mar, Volume: 44, Issue:3 | 2-Acylhydrazino-5-arylpyrrole derivatives: synthesis and antifungal activity evaluation. |
| AID666847 | Antifungal activity against Aspergillus flavus at 6.25 ug/ml after 72 hrs by well plate method | 2012 | European journal of medicinal chemistry, Aug, Volume: 54 | Synthesis, characterization and antimicrobial studies of some new quinoline incorporated benzimidazole derivatives. |
| AID1767309 | Antifungal activity against Candida parapsilosis ATCC 22019 assessed as fungal growth inhibition by CLSI protocol based microbroth dilution method | 2021 | European journal of medicinal chemistry, Oct-05, Volume: 221 | Discovery of novel purinylthiazolylethanone derivatives as anti-Candida albicans agents through possible multifaceted mechanisms. |
| AID49098 | The compound was tested for minimal inhibitory concentration against Candida albicans | 2002 | Bioorganic & medicinal chemistry letters, Sep-02, Volume: 12, Issue:17 | The activity of p-methoxybenzylisothiocyanate against Neisseria gonorrhoeae, Haemophilus ducreyi, and other microorganisms. |
| AID1602366 | Antifungal activity against Candida albicans 7781 after 48 hrs by spectrophotometery | 2019 | Journal of medicinal chemistry, 03-14, Volume: 62, Issue:5 | Discovery of Carboline Derivatives as Potent Antifungal Agents for the Treatment of Cryptococcal Meningitis. |
| AID561427 | Antifungal activity against Candida lusitaniae CL26 by microdilution method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Nonsense and missense mutations in FCY2 and FCY1 genes are responsible for flucytosine resistance and flucytosine-fluconazole cross-resistance in clinical isolates of Candida lusitaniae. |
| AID1594994 | Antileishmanial activity against late log/stationary phase of promastigote stage of Leishmania donovani MHOM/NP/02/BPK282/0c14 assessed as parasite growth inhibition after 72 hrs by plate reader based Alamar blue assay | 2019 | European journal of medicinal chemistry, May-15, Volume: 170 | Evaluation of synthetic substituted 1,2-dioxanes as novel agents against human leishmaniasis. |
| AID486715 | Antifungal activity against Candida parapsilosis ATCC 22019 after 24 hrs by macrodilution method | 2010 | European journal of medicinal chemistry, Jun, Volume: 45, Issue:6 | Design, synthesis and determination of antifungal activity of 5(6)-substituted benzotriazoles. |
| AID509276 | Permeability across BBMEC co-cultured with rat C6 cell BBB model after 24 hrs in presence of 0.01 ug/ml interleukin-1 | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Effects of immunomodulatory and organism-associated molecules on the permeability of an in vitro blood-brain barrier model to amphotericin B and fluconazole. |
| AID424621 | Antimicrobial activity against azole-susceptible Candida albicans isolate CA14 after 48 hrs by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | In vitro interactions between tacrolimus and azoles against Candida albicans determined by different methods. |
| AID329029 | Antifungal activity against Candida albicans ATCC 10231 at 400 ug/disc after 24 hrs by disc diffusion assay | 2008 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 18, Issue:8 | Synthesis and antimicrobial properties of monensin A esters. |
| AID582788 | Antifungal activity against Candida albicans isolate 488 harboring ERG3 H243N, T330A, A351V and ERG11 D225G, E266D, E391G, V488I mutant genes assessed as lanosterol/obtusifoliol content in total sterol composition at 0.5 times MIC by GC-MS analysis | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | Identification and characterization of four azole-resistant erg3 mutants of Candida albicans. |
| AID1890269 | Antifungal activity against Mucor circinelloides R7B wild type strain assessed as reduction in spore germination at 150 ug/ml relative to control | 2022 | Bioorganic & medicinal chemistry letters, 05-01, Volume: 63 | Novel 2-aryl-4-aryloxyquinoline-based fungistatics for Mucor circinelloides. Biological evaluation of activity, QSAR and docking study. |
| AID581872 | Antifungal activity against Candida glabrata isolated from neutropenic subject 1187 with AML or MDS stool after 22 days prophylaxis by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Impact of antifungal prophylaxis on colonization and azole susceptibility of Candida species. |
| AID1337067 | Antifungal activity against fluconazole-resistant Candida albicans clinical isolate 45 | 2017 | ACS medicinal chemistry letters, Feb-09, Volume: 8, Issue:2 | Potent Antifungal Synergy of Phthalazinone and Isoquinolones with Azoles Against |
| AID762703 | Antimicrobial activity against Aspergillus flavus MTCC 873 | 2013 | Bioorganic & medicinal chemistry letters, Aug-15, Volume: 23, Issue:16 | Novel pyrazoline amidoxime and their 1,2,4-oxadiazole analogues: synthesis and pharmacological screening. |
| AID127840 | Compound was evaluated in vivo for antifungal activity and efficacy in disseminated murine candidiasis was determined | 2001 | Bioorganic & medicinal chemistry letters, Jul-23, Volume: 11, Issue:14 | Synthesis and biological activity of novel macrocyclic antifungals. modification of the tyrosine moiety of the lipopeptidolactone FR901469. |
| AID1918388 | Anti-inflammatory activity in mouse infected with Candida albicans assessed as reduction in COX-2 expression in spleen at 20 mg/kg, ip administered on days 2,4,6,8,10,12 and measured on day 14 by immunohistochemical analysis | 2022 | Journal of medicinal chemistry, 11-10, Volume: 65, Issue:21 | Novel Aryl Alkamidazole Derivatives as Multifunctional Antifungal Inhibitors: Design, Synthesis, and Biological Evaluation. |
| AID274126 | Antifungal activity against Trichophyton rubrum after 7 days | 2006 | Bioorganic & medicinal chemistry letters, Oct-15, Volume: 16, Issue:20 | Design, synthesis, and antifungal activities in vitro of novel tetrahydroisoquinoline compounds based on the structure of lanosterol 14alpha-demethylase (CYP51) of fungi. |
| AID638558 | Antifungal activity against Candida krusei Berkout KCCM 11655 after 1 day by twofold broth dilution method | 2012 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 22, Issue:1 | Synthesis and antifungal activity of 6,7-bis(arylthio)-quinazoline-5,8-diones and furo[2,3-f]quinazolin-5-ols. |
| AID1674370 | Unbound volume of distribution at steady state in human | 2020 | Journal of medicinal chemistry, 11-12, Volume: 63, Issue:21 | Integrating the Impact of Lipophilicity on Potency and Pharmacokinetic Parameters Enables the Use of Diverse Chemical Space during Small Molecule Drug Optimization. |
| AID1888262 | Antifungal activity against Aspergillus fumigatus KM8001 assessed as fungal growth inhibition measured after 72 hrs by CLSI protocol based liquid medium dilution method | |||
| AID598223 | Antimicrobial activity against Candida albicans isolate 41 after 48 hrs by microdilution broth method | 2011 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 21, Issue:11 | Synthesis and in vitro antimicrobial activities of new (cyano-NNO-azoxy)pyrazole derivatives. |
| AID407011 | Antimicrobial activity against fluconazole-resistant Candida albicans FH5 dissociated biofilms at cell density of 10'8 cells/ml after 48 hrs by XTT assay | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | Role for cell density in antifungal drug resistance in Candida albicans biofilms. |
| AID535913 | Antifungal activity against Candida tropicalis ATCC 1369 after 24 hrs by broth microdilution method | 2010 | European journal of medicinal chemistry, Nov, Volume: 45, Issue:11 | Synthesis and pharmacological evaluation of clubbed isopropylthiazole derived triazolothiadiazoles, triazolothiadiazines and mannich bases as potential antimicrobial and antitubercular agents. |
| AID1890294 | Inhibition of CYP51 in mouse NIH/3T3 cells assessed as specific enzymatic activity at 100 ug/ml incubated for 48 hrs by ELISA analysis | 2022 | Bioorganic & medicinal chemistry letters, 05-01, Volume: 63 | Novel 2-aryl-4-aryloxyquinoline-based fungistatics for Mucor circinelloides. Biological evaluation of activity, QSAR and docking study. |
| AID581880 | Antifungal activity against Candida glabrata isolated from HSCT recipient 474 with acute or chronic GVHD mouth after 124 days prophylaxis by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Impact of antifungal prophylaxis on colonization and azole susceptibility of Candida species. |
| AID293875 | Antifungal activity against Candida albicans ATCC 10231 after 48 to 72 hrs by broth microdilution method | 2007 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 17, Issue:6 | Synthesis of pseudopeptides based L-tryptophan as a potential antimicrobial agent. |
| AID566888 | Antifungal activity against Cladophialophora carrionii by microdilution test | 2011 | European journal of medicinal chemistry, Jan, Volume: 46, Issue:1 | Synthesis and antifungal activity of some substituted phenothiazines and related compounds. |
| AID1758049 | Anti-biofilm activity in Candida albicans CPCC400616 assessed as inhibition of biofilm formation incubated for 24 hrs with 24 hrs precultured fungal suspension by XTT assay | 2021 | European journal of medicinal chemistry, Apr-15, Volume: 216 | Lead optimization generates selenium-containing miconazole CYP51 inhibitors with improved pharmacological profile for the treatment of fungal infections. |
| AID29423 | HPLC capacity factor (k') | 2002 | Journal of medicinal chemistry, Jun-20, Volume: 45, Issue:13 | Prediction of volume of distribution values in humans for neutral and basic drugs using physicochemical measurements and plasma protein binding data. |
| AID1415614 | Antifungal activity against fluconazole-resistant Candida albicans clinical isolate 103 by broth microdilution method | 2017 | MedChemComm, May-01, Volume: 8, Issue:5 | Synthesis and synergistic antifungal effects of monoketone derivatives of curcumin against fluconazole-resistant |
| AID436281 | Antifungal activity against Aspergillus fumigatus ATCC 10894 by microplate reader assay | 2008 | Journal of natural products, Nov, Volume: 71, Issue:11 | Pestalazines and pestalamides, bioactive metabolites from the plant pathogenic fungus Pestalotiopsis theae. |
| AID1380514 | Antifungal activity against Candida albicans ATCC 90028 planktonic cells assessed as inhibition of fungal growth incubated for 48 hrs by broth microdilution assay | 2018 | Bioorganic & medicinal chemistry letters, 06-01, Volume: 28, Issue:10 | Biofilm inhibition and anti-Candida activity of a cationic lipo-benzamide molecule with twin-nonyl chain. |
| AID1624172 | Antifungal activity against Candida albicans NR-29446 after 24 hrs by microbroth dilution method | 2019 | Bioorganic & medicinal chemistry letters, 03-01, Volume: 29, Issue:5 | Benzimidazole tethered pyrrolo[3,4-b]quinoline with broad-spectrum activity against fungal pathogens. |
| AID1886047 | Synergistic antifungal activity against Cryptococcus neoformans clinical isolate SH68 assessed as fractional inhibitory concentration index incubated for 72 hrs in presence of P163-0892 by broth microdilution method | |||
| AID407012 | Antimicrobial activity against fluconazole-resistant Candida albicans FH5 intact biofilms after 48 hrs by XTT assay | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | Role for cell density in antifungal drug resistance in Candida albicans biofilms. |
| AID1309047 | Antifungal activity against Candida albicans ATCC 64124 after 48 hrs by CLSI M27-A3 method | 2016 | Bioorganic & medicinal chemistry, 08-15, Volume: 24, Issue:16 | Synthesis and investigation of novel benzimidazole derivatives as antifungal agents. |
| AID472407 | Antifungal activity against Candida krusei ATCC 6258 after 48 hrs by broth microdilution method | 2010 | Bioorganic & medicinal chemistry, Apr-15, Volume: 18, Issue:8 | Synthesis, anticonvulsant and antimicrobial activities of some new 2-acetylnaphthalene derivatives. |
| AID582255 | Antifungal activity against Candida glabrata isolated from neutropenic subjects with AML or MDS prior to initiation of fluconazole therapy assessed as maximum MIC by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Impact of antifungal prophylaxis on colonization and azole susceptibility of Candida species. |
| AID1888422 | Upregulation of ERG11 expression in azole-resistant Candida albicans 0304103 at 8 ug/ml by RT-PCR analysis | 2022 | European journal of medicinal chemistry, Jan-05, Volume: 227 | Heat shock protein 90 (Hsp90)/Histone deacetylase (HDAC) dual inhibitors for the treatment of azoles-resistant Candida albicans. |
| AID1698475 | Antifungal activity against Trichophyton rubrum SNB-TR1 assessed as reduction in microbial growth after 5 days by microdilution method | 2020 | Journal of natural products, 10-23, Volume: 83, Issue:10 | Paecilosetin Derivatives as Potent Antimicrobial Agents from |
| AID1419568 | Selectivity index, ratio of EC50 for toxicity in human BEAS2B cells to MIC50 for antifungal activity against Candida krusei ATCC 6258 | 2017 | European journal of medicinal chemistry, Jun-16, Volume: 133 | Novel alkylated azoles as potent antifungals. |
| AID1491244 | Antifungal activity against Candida tropicalis cgmcc 2.3739 by broth microdilution method | 2017 | European journal of medicinal chemistry, Sep-08, Volume: 137 | Design, synthesis and evaluation of aromatic heterocyclic derivatives as potent antifungal agents. |
| AID551207 | Antifungal activity against Candida parapsilosis by broth microdilution method | 2011 | Bioorganic & medicinal chemistry letters, Jan-15, Volume: 21, Issue:2 | New azoles with antifungal activity: Design, synthesis, and molecular docking. |
| AID584381 | Ratio of URA3 gene expression in Candida glabrata isolated from patient 807 receiving antifungal drug to URA3 gene expression in Candida glabrata isolated from patient 807 by RT-PCR analysis | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Impact of antifungal prophylaxis on colonization and azole susceptibility of Candida species. |
| AID1416198 | Antifungal activity against Candida mycoderma by two-fold serial dilution method | 2017 | MedChemComm, Aug-01, Volume: 8, Issue:8 | Discovery of potential antifungal triazoles: design, synthesis, biological evaluation, and preliminary antifungal mechanism exploration. |
| AID406857 | Antimicrobial activity against Candida albicans SC5314 at planktonic cell density of 10'3 cells/ml after 48 hrs by XTT assay | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | Role for cell density in antifungal drug resistance in Candida albicans biofilms. |
| AID1196782 | Inhibition of recombinant full-length Trypanosoma cruzi CYP51 assessed as molar ratio of inhibitor to enzyme which causes 2 fold decrease in enzyme activity in 5 mins by HPLC analysis | 2015 | Journal of medicinal chemistry, Feb-12, Volume: 58, Issue:3 | Novel 3-nitrotriazole-based amides and carbinols as bifunctional antichagasic agents. |
| AID1487221 | Inhibition of CYP11B1 in human hepatocyte microsomes using deoxycortisol substrate by HPLC/MS/MS method | 2017 | Bioorganic & medicinal chemistry letters, 08-01, Volume: 27, Issue:15 | Design and optimization of highly-selective, broad spectrum fungal CYP51 inhibitors. |
| AID1516837 | Antifungal activity against Candida albicans | 2019 | Bioorganic & medicinal chemistry letters, 10-01, Volume: 29, Issue:19 | Recent advances in natural antifungal flavonoids and their derivatives. |
| AID603344 | Antifungal activity against Cryptococcus neoformans ATCC BLS108 after 72 hrs by micro-broth dilution method | 2011 | European journal of medicinal chemistry, Jul, Volume: 46, Issue:7 | Design, synthesis and molecular docking studies of novel triazole as antifungal agent. |
| AID1783811 | Inhibition of Candida albicans CYP51 assessed as eburicol level at 0.25 ug/ml measured after 18 hrs by GC-MS analysis relative to control | 2021 | European journal of medicinal chemistry, Nov-15, Volume: 224 | Improving the metabolic stability of antifungal compounds based on a scaffold hopping strategy: Design, synthesis, and structure-activity relationship studies of dihydrooxazole derivatives. |
| AID553843 | Antifungal activity against Saccharomyces cerevisiae AD12345678 in YNPG-proline medium after 24 hrs by microdilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | Enhanced susceptibility to antifungal oligopeptides in yeast strains overexpressing ABC multidrug efflux pumps. |
| AID1265645 | Antifungal activity against Candida sake clinical isolate after 24 hrs by sabouraud dextrose broth based microdilution method | 2016 | European journal of medicinal chemistry, Jan-01, Volume: 107 | Anti-Candida activity and cytotoxicity of a large library of new N-substituted-1,3-thiazolidin-4-one derivatives. |
| AID1762168 | Antifungal activity against Candida utilis 84 assessed as reduction in fungal growth incubated for 24 hrs by CLSI based serial microbroth dilution method | 2021 | Bioorganic & medicinal chemistry letters, 05-15, Volume: 40 | Synthesis and antifungal activity of new hybrids thiazolo[4,5-d]pyrimidines with (1H-1,2,4)triazole. |
| AID1877871 | Induction of mitochondrial membrane potential loss in Candida albicans at 1 ug/ml after 16 hrs by JC-1 staining based fluorescence microplate reader | 2022 | Bioorganic & medicinal chemistry letters, 02-15, Volume: 58 | Synthesis and antifungal evaluation of phenol-derived bis(indolyl)methanes combined with FLC against Candida albicans. |
| AID1898231 | Induction of hemolysis in rabbit RBC at 64 ug/ml incubated for 1 hr | |||
| AID424884 | Antimicrobial activity against azole-resistant Candida albicans isolate CA10 assessed as growth at 16 ug/ml co-treated with 0.031 ug/ml calcineurin signaling inhibitor tacrolimus after 48 hrs by microdilution checkboard technique relative to control | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | In vitro interactions between tacrolimus and azoles against Candida albicans determined by different methods. |
| AID598301 | Antimicrobial activity against Cryptococcus neoformans var. neoformans isolate 27 after 48 hrs by microdilution broth method | 2011 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 21, Issue:11 | Synthesis and in vitro antimicrobial activities of new (cyano-NNO-azoxy)pyrazole derivatives. |
| AID1890279 | Antifungal activity against Trichophyton mentagrophytes clinical isolate 3 assessed as reduction in fungal growth by broth dilution method | 2022 | Bioorganic & medicinal chemistry letters, 05-01, Volume: 63 | Novel 2-aryl-4-aryloxyquinoline-based fungistatics for Mucor circinelloides. Biological evaluation of activity, QSAR and docking study. |
| AID1168335 | Binding affinity to human serum albumin by spectroscopy in presence of Zn2+ | 2014 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 24, Issue:21 | Study the interactions between human serum albumin and two antifungal drugs: fluconazole and its analogue DTP. |
| AID584593 | Antifungal activity against 56 days cultured Candida glabrata isolated from HSCT recipient with acute or chronic GVHD mouth receiving antifungal therapy for 172 days after 114 days of prophylaxis by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Impact of antifungal prophylaxis on colonization and azole susceptibility of Candida species. |
| AID28236 | Unbound fraction (tissues) | 2002 | Journal of medicinal chemistry, Jun-20, Volume: 45, Issue:13 | Prediction of volume of distribution values in humans for neutral and basic drugs using physicochemical measurements and plasma protein binding data. |
| AID356370 | Antifungal activity against Candida albicans ATCC 90028 by sphingolipid reversal assay in presence of 30 ug/mL stearylamine | 2003 | Journal of natural products, Aug, Volume: 66, Issue:8 | Acetylenic acids inhibiting azole-resistant Candida albicans from Pentagonia gigantifolia. |
| AID440339 | Antifungal activity against Aspergillus fumigatus NCIM 902 at 10 ug/ml after 2 to 3 days by serial plate dilution method | 2009 | European journal of medicinal chemistry, Dec, Volume: 44, Issue:12 | Synthesis and antimicrobial activity of some new N-acyl substituted phenothiazines. |
| AID371237 | Antimicrobial activity against Aspergillus fumigatus SANK 18497 by broth microdilution method | 2008 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 18, Issue:24 | Carbon analogs of antifungal dioxane-triazole derivatives: synthesis and in vitro activities. |
| AID516300 | Antimicrobial activity against fluconazole-resistant Cryptococcus gattii serotype B isolate RB14 at 256 ug/ml | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Heteroresistance of Cryptococcus gattii to fluconazole. |
| AID1059358 | Fungicidal activity against Candida parapsilosis by micro dilution method | 2013 | European journal of medicinal chemistry, , Volume: 70 | Designing and synthesis of novel antimicrobial heterocyclic analogs of fatty acids. |
| AID1904369 | Antifungal activity against FLC-resistant Candida albicans 100 assessed as fungal growth inhibition by CLSI based serial microbroth dilution method | 2022 | European journal of medicinal chemistry, Apr-05, Volume: 233 | Design, synthesis, and evaluation of novel 3-thiophene derivatives as potent fungistatic and fungicidal reagents based on a conformational restriction strategy. |
| AID1187441 | Antifungal activity against Candida albicans after 24 hrs by serial dilution method | 2014 | Bioorganic & medicinal chemistry letters, Sep-01, Volume: 24, Issue:17 | Scaffold hopping of sampangine: discovery of potent antifungal lead compound against Aspergillus fumigatus and Cryptococcus neoformans. |
| AID1418532 | Antifungal activity against Candida tropicalis cgmcc 2.3739 after 2 to 7 days by broth microdilution method | 2018 | Bioorganic & medicinal chemistry letters, 12-01, Volume: 28, Issue:22 | Design, synthesis, and biological evaluation of 4-chloro-2H-thiochromenes featuring nitrogen-containing side chains as potent antifungal agents. |
| AID420069 | Antifungal activity against Candida albicans CA-6 infected in CD1 mouse assessed as reduction of fungal burden in kidneys treated with 0.3 ml serum of 10 mg/kg, ip dosed mouse collected after 1 hr determined 7 days post-infection | 2009 | Bioorganic & medicinal chemistry, Jun-01, Volume: 17, Issue:11 | Bulky 1,4-benzoxazine derivatives with antifungal activity. |
| AID457995 | Antifungal activity against Aspergillus fumigatus 231 after 24 hrs by microdilution method | 2010 | Bioorganic & medicinal chemistry, Mar-01, Volume: 18, Issue:5 | Antifungal 3,5-disubstituted furanones: From 5-acyloxymethyl to 5-alkylidene derivatives. |
| AID125938 | In vitro antifungal activity against Microsporum canis | 2003 | Journal of medicinal chemistry, Feb-13, Volume: 46, Issue:4 | Structure-based de novo design, synthesis, and biological evaluation of non-azole inhibitors specific for lanosterol 14alpha-demethylase of fungi. |
| AID608609 | Antimicrobial activity against Pseudomonas aeruginosa ATCC 278533 after 24 hrs by microdilution technique | 2011 | European journal of medicinal chemistry, Jul, Volume: 46, Issue:7 | New condensed pyrroles of potential biological interest syntheses and structure-activity relationship studies. |
| AID1076260 | Antifungal activity against Aspergillus flavus assessed as growth inhibition by NCCLS broth dilution assay | 2014 | European journal of medicinal chemistry, Mar-21, Volume: 75 | Synthesis, docking and evaluation of antioxidant and antimicrobial activities of novel 1,2,4-triazolo[3,4-b][1,3,4]thiadiazol-6-yl)selenopheno[2,3-d]pyrimidines. |
| AID589646 | Antifungal activity against Aspergillus flavus | 2011 | European journal of medicinal chemistry, Apr, Volume: 46, Issue:4 | Synthesis of some novel 3-(1-(1-substitutedpiperidin-4-yl)-1H-1,2,3-triazol-4-yl)-5-substituted phenyl-1,2,4-oxadiazoles as antifungal agents. |
| AID1348088 | Antimicrobial activity against Pseudomonas aeruginosa ATCC 27853 assessed as zone of inhibition at 50 ug per disc after 24 hrs by disc diffusion assay | 2018 | European journal of medicinal chemistry, Jan-01, Volume: 143 | Synthesis of new 1-benzyl tetrahydropyridinylidene ammonium salts and their antimicrobial and anticellular activities. |
| AID1864878 | Antifungal activity against fluconazole- resistant Candida albicans 17# assessed as fungal growth inhibition measured after 72 hrs by double dilution method | |||
| AID1369446 | Antifungal activity against Candida albicans SP3902 after 48 hrs by broth microdilution method | 2018 | Journal of medicinal chemistry, 05-10, Volume: 61, Issue:9 | Combating Drug-Resistant Fungi with Novel Imperfectly Amphipathic Palindromic Peptides. |
| AID1498765 | Antifungal activity against Aspergillus flavus after 24 hrs by two fold serial dilution based spectrophotometric analysis | 2018 | Bioorganic & medicinal chemistry letters, 08-01, Volume: 28, Issue:14 | Azoalkyl ether imidazo[2,1-b]benzothiazoles as potentially antimicrobial agents with novel structural skeleton. |
| AID448699 | Antimicrobial activity against Saccharomyces cerevisiae ATCC 9763 after 24 hrs by broth microdilution method | 2009 | European journal of medicinal chemistry, Nov, Volume: 44, Issue:11 | Synthesis of new 4-isopropylthiazole hydrazide analogs and some derived clubbed triazole, oxadiazole ring systems--a novel class of potential antibacterial, antifungal and antitubercular agents. |
| AID519065 | Antifungal activity against Candida tropicalis assessed as resistant isolates after 48 hrs by broth microdilution | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | Antimicrobial activity of omiganan pentahydrochloride against contemporary fungal pathogens responsible for catheter-associated infections. |
| AID1674369 | Volume of distribution at steady state in human | 2020 | Journal of medicinal chemistry, 11-12, Volume: 63, Issue:21 | Integrating the Impact of Lipophilicity on Potency and Pharmacokinetic Parameters Enables the Use of Diverse Chemical Space during Small Molecule Drug Optimization. |
| AID518152 | Antimicrobial activity against Cryptococcus gattii serotype C isolate NIH139 assessed as concentration required for heteroresistance | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Heteroresistance of Cryptococcus gattii to fluconazole. |
| AID525602 | Antibacterial activity against Fluconazole resistant Candida albicans DSY3606 containing tac1delta/delta ERG11-1/ERG11-1 (TAC1-5) genotype by EUCAST standards based broth microdilution method sCandida albicans DSY294 | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Genetic dissection of azole resistance mechanisms in Candida albicans and their validation in a mouse model of disseminated infection. |
| AID405041 | Antifungal activity against Sporothrix schenckii P10012 isolate from cutaneous-lymphatic sporotrichosis patient after 72 hrs by ATB Fungus 2 method | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | In vitro susceptibility of Sporothrix schenckii to six antifungal agents determined using three different methods. |
| AID581896 | Antifungal activity against Candida glabrata isolated from neutropenic subject 1331 with AML or MDS pharynx after 21 days prophylaxis by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Impact of antifungal prophylaxis on colonization and azole susceptibility of Candida species. |
| AID340964 | Antifungal activity against Pichia anomala isolates from grapes by NCCLS M27-A2 method | 2007 | Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8 | Cross-resistance to medical and agricultural azole drugs in yeasts from the oropharynx of human immunodeficiency virus patients and from environmental Bavarian vine grapes. |
| AID518409 | Antimicrobial activity against Cryptococcus gattii serotype B isolate B5763 assessed as heteroresistant isolates at 2 ug/ml | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Heteroresistance of Cryptococcus gattii to fluconazole. |
| AID1265821 | Antifungal activity against Aspergillus nidulans ATCC 38163 after 48 hrs by microbroth dilution method | 2015 | Journal of medicinal chemistry, Dec-10, Volume: 58, Issue:23 | Synthesis and Bioactivities of Kanamycin B-Derived Cationic Amphiphiles. |
| AID1738712 | Antifungal activity against fluconazole-resistant Candida albicans strain 904 measured after 24 hrs by micro-broth dilution assay | 2020 | European journal of medicinal chemistry, Jul-15, Volume: 198 | Design, synthesis, and biological evaluation of novel miconazole analogues containing selenium as potent antifungal agents. |
| AID495350 | Antimicrobial activity against fluconazole susceptible Candida albicans isolate 580 expressing low levels of ERG11 and UPC2 mRNA by microdilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | An A643T mutation in the transcription factor Upc2p causes constitutive ERG11 upregulation and increased fluconazole resistance in Candida albicans. |
| AID1401693 | Antifungal against Candida albicans ATCC 76615 after 24 hrs by two fold serial dilution method | 2018 | European journal of medicinal chemistry, Jan-01, Volume: 143 | Novel aminopyrimidinyl benzimidazoles as potentially antimicrobial agents: Design, synthesis and biological evaluation. |
| AID285699 | Survival of neonatal Wistar rat infected with Candida albicans ATCC 32354 at 10 mg/kg of body weight/day, ip for 4 days beginning 24 hrs before infection | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Neonatal coinfection model of coagulase-negative Staphylococcus (Staphylococcus epidermidis) and Candida albicans: fluconazole prophylaxis enhances survival and growth. |
| AID1054664 | Antimicrobial activity against Candida glabrata at 20 ug/ml by Alamar blue method | 2013 | European journal of medicinal chemistry, , Volume: 70 | Structure-activity relationship (SAR) and preliminary mode of action studies of 3-substituted benzylthioquinolinium iodide as anti-opportunistic infection agents. |
| AID448309 | Antimicrobial activity against Candida albicans ATCC 60193 at 5 ug after 18 hrs by well diffusion method | 2009 | European journal of medicinal chemistry, Nov, Volume: 44, Issue:11 | Synthesis of some new 1,2,4-triazoles starting from isonicotinic acid hydrazide and evaluation of their antimicrobial activities. |
| AID477306 | Antifungal activity against Mucor after 1 to 7 days by twofold serial dilution method | 2010 | European journal of medicinal chemistry, Apr, Volume: 45, Issue:4 | Synthesis and in vitro microbiological evaluation of an array of biolabile 2-morpholino-N-(4,6-diarylpyrimidin-2-yl)acetamides. |
| AID1898186 | Induction of drug resistance in Candida albicans SC5314 assessed as increase in MIC after 26 days | |||
| AID674384 | Antifungal activity against Aspergillus flavus MTCC 3306 at 1 mg/ml after 72 hrs by well plate method | 2012 | Bioorganic & medicinal chemistry letters, Jul-15, Volume: 22, Issue:14 | Synthesis of benzofuran based 1,3,5-substituted pyrazole derivatives: as a new class of potent antioxidants and antimicrobials--a novel accost to amend biocompatibility. |
| AID1157179 | Antifungal activity against Microsporum gypseum DSM 3824 after 72 hrs by CLSI broth microdilution method | 2014 | European journal of medicinal chemistry, Aug-18, Volume: 83 | Synthesis, biological evaluation and structure-activity correlation study of a series of imidazol-based compounds as Candida albicans inhibitors. |
| AID1762165 | Antifungal activity against Aspergillus niger 37a assessed as reduction in fungal growth incubated for 48 hrs by CLSI based serial microbroth dilution method | 2021 | Bioorganic & medicinal chemistry letters, 05-15, Volume: 40 | Synthesis and antifungal activity of new hybrids thiazolo[4,5-d]pyrimidines with (1H-1,2,4)triazole. |
| AID1295985 | Cytotoxicity against human HeLa cells after 48 hrs by SRB assay | 2016 | Journal of natural products, Feb-26, Volume: 79, Issue:2 | Antifungal Quinoline Alkaloids from Waltheria indica. |
| AID52096 | Compound was tested for inhibitory activity against Candida albicans Chitin synthase 1; NT means not tested | 2000 | Bioorganic & medicinal chemistry letters, Jul-03, Volume: 10, Issue:13 | Synthesis and structure-activity relationships of novel fungal chitin synthase inhibitors. |
| AID1598012 | Antifungal activity against Candida kefyr | 2019 | European journal of medicinal chemistry, May-15, Volume: 170 | Current advances of triazole alcohols derived from fluconazole: Design, in vitro and in silico studies. |
| AID1391391 | Antifungal activity against Aspergillus fumigatus after 24 hrs by two fold serial dilution method | 2018 | Bioorganic & medicinal chemistry letters, 05-15, Volume: 28, Issue:9 | Novel purine benzimidazoles as antimicrobial agents by regulating ROS generation and targeting clinically resistant Staphylococcus aureus DNA groove. |
| AID310104 | Antifungal activity against Mucor sp. by disc diffusion method | 2007 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 17, Issue:22 | Synthesis and antimicrobial activity of some novel nucleoside analogues of adenosine and 1,3-dideazaadenosine. |
| AID208065 | In vitro antifungal activity against Trichophyton rubrum CM1447 | 2002 | Journal of medicinal chemistry, Oct-24, Volume: 45, Issue:22 | Synthesis, antifungal activity, and molecular modeling studies of new inverted oxime ethers of oxiconazole. |
| AID750286 | Antifungal activity against Candida tropicalis ATCC 750 after 24 to 48 hrs by broth microdilution method | 2013 | European journal of medicinal chemistry, Jun, Volume: 64 | 2-Aminobenzothiazole derivatives: search for new antifungal agents. |
| AID1419504 | Antifungal activity against Aspergillus nidulans ATCC 38163 incubated for 48 hrs by CLSI M38-A2 protocol based method | 2017 | European journal of medicinal chemistry, Jun-16, Volume: 133 | Novel alkylated azoles as potent antifungals. |
| AID648383 | Antifungal activity against Botrytis cinerea after 48 to 72 hrs by twofold serial dilution method | 2012 | European journal of medicinal chemistry, May, Volume: 51 | Synthesis of novel spirooxindole derivatives by one pot multicomponent reaction and their antimicrobial activity. |
| AID772330 | Antifungal activity against wild type Candida glabrata after 24 hrs by visually and spectrophotometric analysis | 2013 | ACS medicinal chemistry letters, Sep-12, Volume: 4, Issue:9 | Novel Macrocyclic Amidinoureas: Potent Non-Azole Antifungals Active against Wild-Type and Resistant Candida Species. |
| AID638561 | Antifungal activity against Aspergillus flavus KCCM 11899 after 2 days by twofold broth dilution method | 2012 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 22, Issue:1 | Synthesis and antifungal activity of 6,7-bis(arylthio)-quinazoline-5,8-diones and furo[2,3-f]quinazolin-5-ols. |
| AID1239802 | Inhibition of Candida albicans lanosterol 14-alpha demethylase assessed as reduction of ergosterol biosynthesis at 50 ug/ml after 18 hrs by UV spectroscopy analysis | 2015 | Bioorganic & medicinal chemistry letters, Sep-01, Volume: 25, Issue:17 | Design, synthesis and evaluation of benzotriazole derivatives as novel antifungal agents. |
| AID1728508 | Inhibition of CYP51 in Candida albicans ATCC SC5314 assessed as ergosterol level at 0.125 ug/ml incubated for 48 hrs by LC/MS analysis (Rvb = 95.1 %) | 2021 | European journal of medicinal chemistry, Jan-15, Volume: 210 | Novel naphthylamide derivatives as dual-target antifungal inhibitors: Design, synthesis and biological evaluation. |
| AID425167 | Antifungal activity against Candida glabrata isolate 4370 after 48 hrs by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | Posaconazole activity against Candida glabrata after exposure to caspofungin or amphotericin B. |
| AID1168341 | Binding affinity to human serum albumin by spectroscopy in presence of Cr3+ | 2014 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 24, Issue:21 | Study the interactions between human serum albumin and two antifungal drugs: fluconazole and its analogue DTP. |
| AID341411 | Antimicrobial activity against 9 x 10'6 CFU Cryptococcus neoformans USC1597 isolate intracranially infected in Hartley guinea pig assessed as brain bacterial count per gram at 10 mg/kg, po BID administered 48 hrs postinfection for 13 days | 2007 | Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8 | New guinea pig model of Cryptococcal meningitis. |
| AID446455 | Antifungal activity against fluconazole-resistant Candida glabrata CG468 | 2009 | Bioorganic & medicinal chemistry letters, Oct-15, Volume: 19, Issue:20 | Design of new antifungal agents: synthesis and evaluation of 1-[(1H-indol-5-ylmethyl)amino]-2-phenyl-3-(1H-1,2,4-triazol-1-yl)propan-2-ols. |
| AID1413342 | Antifungal activity against Fusarium graminearum B4-5A strain B after 48 hrs by microdilution assay | 2018 | MedChemComm, Jun-01, Volume: 9, Issue:6 | Antifungal amphiphilic kanamycins: new life for an old drug. |
| AID208219 | Inhibition of Trichosporon beigelli 1188 for 24 hours in vitro. | 2001 | Journal of medicinal chemistry, Aug-16, Volume: 44, Issue:17 | 3-Phenyl-5-acyloxymethyl-2H,5H-furan-2-ones: synthesis and biological activity of a novel group of potential antifungal drugs. |
| AID509281 | Permeability across BBMEC cocultured with rat C6 cell BBB model after 24 hrs in presence of 1 ug/ml lipoteichoic acid | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Effects of immunomodulatory and organism-associated molecules on the permeability of an in vitro blood-brain barrier model to amphotericin B and fluconazole. |
| AID642920 | Antifungal activity against Aspergillus fumigatus ATCC 90906 at 160 ug/ml | 2011 | ACS medicinal chemistry letters, May-12, Volume: 2, Issue:5 | Natural Product Based 6-Hydroxy-2,3,4,6-tetrahydropyrrolo[1,2-a]pyrimidinium Scaffold as A New Antifungal Template. |
| AID1334848 | Anti-fungal activity against Candida albicans CPCC 400523 by broth microdilution method | 2017 | Bioorganic & medicinal chemistry, 01-15, Volume: 25, Issue:2 | Discovery of biphenyl imidazole derivatives as potent antifungal agents: Design, synthesis, and structure-activity relationship studies. |
| AID453444 | Antifungal activity against Fusarium proliferatum ATCC 10052 after 48 hrs by broth microdilution method | 2010 | Bioorganic & medicinal chemistry letters, Jan-15, Volume: 20, Issue:2 | Fluconazole analogues containing 2H-1,4-benzothiazin-3(4H)-one or 2H-1,4-benzoxazin-3(4H)-one moieties, a novel class of anti-Candida agents. |
| AID1422686 | Antifungal activity against Cryptococcus neoformans after 24 hrs by resazurin-dye based two fold serial dilution method | 2018 | Bioorganic & medicinal chemistry, 11-01, Volume: 26, Issue:20 | Antifungal benzo[b]thiophene 1,1-dioxide IMPDH inhibitors exhibit pan-assay interference (PAINS) profiles. |
| AID536633 | Antimicrobial activity against Candida albicans ATCC 10145 at 5 mg/ml after 48 hrs by agar well diffusion assay | 2010 | European journal of medicinal chemistry, Nov, Volume: 45, Issue:11 | Synthesis of new pyrrolo[2,3-d]pyrimidine derivatives as antibacterial and antifungal agents. |
| AID1392806 | Inhibition of Cyp51 in Candida albicans ATCC SC5314 assessed as lanosterol content at 0.125 ug/ml after 16 hrs by GC-MS analysis relative to control | 2018 | Bioorganic & medicinal chemistry, 07-23, Volume: 26, Issue:12 | Design, synthesis and evaluation of benzoheterocycle analogues as potent antifungal agents targeting CYP51. |
| AID1911624 | Antifungal activity against Mucor racemosus MZ140 assessed as fungal growth inhibition by broth microdilution assay | 2022 | Journal of medicinal chemistry, 06-09, Volume: 65, Issue:11 | Development of Lipo-γ-AA Peptides as Potent Antifungal Agents. |
| AID1484690 | Antileishmanial activity against Leishmania donovani MHOM/N/1983/AG83 promastigote forms after 8 days | 2017 | European journal of medicinal chemistry, Jul-28, Volume: 135 | An overview of azoles targeting sterol 14α-demethylase for antileishmanial therapy. |
| AID356368 | Antifungal activity against Candida albicans ATCC 90028 by sphingolipid reversal assay in presence of 5 ug/mL stearylamine | 2003 | Journal of natural products, Aug, Volume: 66, Issue:8 | Acetylenic acids inhibiting azole-resistant Candida albicans from Pentagonia gigantifolia. |
| AID1059348 | Fungicidal activity against Candida parapsilosis clinical isolate by micro dilution method | 2013 | European journal of medicinal chemistry, , Volume: 70 | Designing and synthesis of novel antimicrobial heterocyclic analogs of fatty acids. |
| AID1487218 | Inhibition of CYP51 in Aspergillus flavus assessed as inhibition of microbe growth incubated for 48 to 168 hrs by CLSI M27-A3 guideline based method | 2017 | Bioorganic & medicinal chemistry letters, 08-01, Volume: 27, Issue:15 | Design and optimization of highly-selective, broad spectrum fungal CYP51 inhibitors. |
| AID249459 | Ratio of the in vitro minimal inhibitory to that of bifonazole against Candida albicans (MIC(compound)/MIC(bifonazole)) | 2005 | Journal of medicinal chemistry, Aug-11, Volume: 48, Issue:16 | Antifungal agents. 11. N-substituted derivatives of 1-[(aryl)(4-aryl-1H-pyrrol-3-yl)methyl]-1H-imidazole: synthesis, anti-Candida activity, and QSAR studies. |
| AID528080 | Antifungal activity against Candida parapsilosis by broth microdilution method | 2010 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 20, Issue:22 | Stereocontrolled facile synthesis and antimicrobial activity of oximes and oxime ethers of diversely substituted bispidines. |
| AID1602365 | Antifungal activity against Cryptococcus neoformans H99 after 72 hrs by growth curve assay | 2019 | Journal of medicinal chemistry, 03-14, Volume: 62, Issue:5 | Discovery of Carboline Derivatives as Potent Antifungal Agents for the Treatment of Cryptococcal Meningitis. |
| AID1413582 | Inhibition of CYP51 in Candida albicans SC5314 assessed as lanosterol content at 8 ug/ml after 16 hrs by GC/MS analysis (Rvb = 3.9%) | |||
| AID1413343 | Antifungal activity against Fusarium graminearum B4-5A strain C after 48 hrs by microdilution assay | 2018 | MedChemComm, Jun-01, Volume: 9, Issue:6 | Antifungal amphiphilic kanamycins: new life for an old drug. |
| AID405013 | Antifungal activity against Sporothrix schenckii PSSA81 isolate from cutaneous-lymphatic sporotrichosis patient after 72 hrs by Sensititre YeastOne method | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | In vitro susceptibility of Sporothrix schenckii to six antifungal agents determined using three different methods. |
| AID464590 | Antifungal activity against Aspergillus fumigatus ATCC 96918 after 24 hrs by two fold serial dilution method | 2010 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 20, Issue:6 | Synthesis, antibacterial and antifungal activities of some carbazole derivatives. |
| AID1877835 | Antifungal activity against Candida albicans CA3511 by microdilution method | 2022 | Bioorganic & medicinal chemistry letters, 02-15, Volume: 58 | Synthesis and antifungal evaluation of phenol-derived bis(indolyl)methanes combined with FLC against Candida albicans. |
| AID1419498 | Antifungal activity against ITC and FLC-resistant Candida albicans ATCC 1237 incubated for 48 hrs by modified CLSI M27-A3 protocol based method | 2017 | European journal of medicinal chemistry, Jun-16, Volume: 133 | Novel alkylated azoles as potent antifungals. |
| AID499657 | Octanol-phosphate buffered saline partition coefficient, log D of the compound at pH 7.4 | 2010 | Bioorganic & medicinal chemistry, Aug-15, Volume: 18, Issue:16 | Novel antifungal agents: triazolopyridines as inhibitors of beta-1,6-glucan synthesis. |
| AID1517585 | Antifungal activity against Cryptococcus neoformans ATCC 208821 assessed as growth inhibition incubated for 36 hrs by resazurin dye based assay | 2019 | European journal of medicinal chemistry, Dec-01, Volume: 183 | Exploration of the antibiotic potentiating activity of indolglyoxylpolyamines. |
| AID555011 | Antifungal activity against Candida lambica assessed as percent susceptible isolates at 25 ug/disc by CLSI M44-A disk diffusion method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | In vitro activities of fluconazole and voriconazole against clinical isolates of Candida spp. determined by disk diffusion testing in Turin, Italy. |
| AID285874 | Antimicrobial susceptibility of Pichia anomala from nosocomial fungemia patient assessed as percent susceptible isolates by CLSI method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Antifungal drug susceptibility profile of Pichia anomala isolates from patients presenting with nosocomial fungemia. |
| AID1550456 | Antifungal activity against Candida tropicalis IBA 171 assessed as decrease in fungal cell growth incubated for 24 hrs by E-test | 2019 | European journal of medicinal chemistry, Jun-01, Volume: 171 | Antimicrobial and KPC/AmpC inhibitory activity of functionalized benzosiloxaboroles. |
| AID42678 | In vitro antifungal activity against Candida albicans 4711E | 2002 | Journal of medicinal chemistry, Oct-24, Volume: 45, Issue:22 | Synthesis, antifungal activity, and molecular modeling studies of new inverted oxime ethers of oxiconazole. |
| AID509283 | Permeability across BBMEC cocultured with rat C6 cell BBB model after 24 hrs in presence of 0.1 ug/ml Dexamethasone | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Effects of immunomodulatory and organism-associated molecules on the permeability of an in vitro blood-brain barrier model to amphotericin B and fluconazole. |
| AID518663 | Antimicrobial activity against Cryptococcus gattii serotype B isolate B4506 assessed as heteroresistant isolates at 8 ug/ml | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Heteroresistance of Cryptococcus gattii to fluconazole. |
| AID1419542 | Selectivity index, ratio of EC50 for toxicity in human A549 cells to MIC50 for antifungal activity against Candida albicans ATCC 64124 | 2017 | European journal of medicinal chemistry, Jun-16, Volume: 133 | Novel alkylated azoles as potent antifungals. |
| AID1557094 | Cytotoxicity against human HepG2 cells assessed as reduction in cell viability at 5 to 50 uM incubated for 24 hrs by XTT assay relative to control | 2019 | European journal of medicinal chemistry, Oct-01, Volume: 179 | Antifungal activity, mode of action variability, and subcellular distribution of coumarin-based antifungal azoles. |
| AID1364334 | Antimicrobial activity against Cryptococcus neoformans ATCC 208821 by microdilution plate based method | 2017 | Journal of natural products, 04-28, Volume: 80, Issue:4 | Antibacterial Nerol Cinnamates from the Australian Plant Eremophila longifolia. |
| AID518137 | Antimicrobial activity against Cryptococcus gattii serotype B isolate RB-22 assessed as concentration required for heteroresistance | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Heteroresistance of Cryptococcus gattii to fluconazole. |
| AID527140 | Antifungal activity against Candida albicans LMGO 102 after 5 days microdilution technique | 2010 | Journal of natural products, Oct-22, Volume: 73, Issue:10 | Search for antifungal compounds from the wood of durable tropical trees. |
| AID1187439 | Antifungal activity against Aspergillus fumigatus after 7 days by serial dilution method | 2014 | Bioorganic & medicinal chemistry letters, Sep-01, Volume: 24, Issue:17 | Scaffold hopping of sampangine: discovery of potent antifungal lead compound against Aspergillus fumigatus and Cryptococcus neoformans. |
| AID772319 | Antifungal activity against fluconazole-resistant Candida glabrata DSY756 increase expressing of CgCDR1, CgCDR2, and CgSNQ2 genes after 24 hrs by visually and spectrophotometric analysis | 2013 | ACS medicinal chemistry letters, Sep-12, Volume: 4, Issue:9 | Novel Macrocyclic Amidinoureas: Potent Non-Azole Antifungals Active against Wild-Type and Resistant Candida Species. |
| AID582236 | Antifungal activity against Candida glabrata isolated from neutropenic subjects with AML or MDS prior to initiation of posaconazole therapy assessed as maximum MIC by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Impact of antifungal prophylaxis on colonization and azole susceptibility of Candida species. |
| AID1138332 | Antimicrobial activity against Aspergillus fumigatus 7544 after 48 hrs by serial dilution method | 2014 | Journal of medicinal chemistry, May-08, Volume: 57, Issue:9 | Design, synthesis, and structure-activity relationship studies of novel fused heterocycles-linked triazoles with good activity and water solubility. |
| AID1783067 | Antifungal activity against fluconazole-sensitive Candida albicans 7781 assessed as inhibition of fungal growth | 2021 | European journal of medicinal chemistry, Oct-05, Volume: 221 | Lanosterol 14α-demethylase (CYP51)/histone deacetylase (HDAC) dual inhibitors for treatment of Candida tropicalis and Cryptococcus neoformans infections. |
| AID1493836 | Antifungal activity against fluconazole-resistant Candida albicans clinical isolate 1010 after 24 hrs by spectrophotometric analysis | 2018 | European journal of medicinal chemistry, Jan-01, Volume: 143 | Discovery of simplified sampangine derivatives as novel fungal biofilm inhibitors. |
| AID1430054 | Anti-fungal activity against Trichophyton mentagrophytes after 48 hrs by broth microdilution method | |||
| AID1494183 | Antifungal activity against Aspergillus nidulans ATCC 38163 measured after 48 hrs by CLSI M38-A2 protocol based method | 2018 | Bioorganic & medicinal chemistry, 02-01, Volume: 26, Issue:3 | Novel fluconazole derivatives with promising antifungal activity. |
| AID285701 | Increase in growth of neonatal Wistar rat infected with Candida albicans ATCC 32354 assessed as weight gain at 10 mg/kg of body weight/day, ip for 4 days beginning 24 hrs before infection relative to control | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Neonatal coinfection model of coagulase-negative Staphylococcus (Staphylococcus epidermidis) and Candida albicans: fluconazole prophylaxis enhances survival and growth. |
| AID1888264 | Antifungal activity against fluconazole resistant Candida albicans strain CaR assessed as fungal growth inhibition measured after 72 hrs by CLSI protocol based liquid medium dilution method | |||
| AID583000 | Antimicrobial activity against Saccharomyces cerevisiae YUG37 transformed with plasmid carrying cyp51A gene in reverse orientation without doxycycline-regulatable promoter by broth dilution method | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | Complementation of a Saccharomyces cerevisiae ERG11/CYP51 (sterol 14α-demethylase) doxycycline-regulated mutant and screening of the azole sensitivity of Aspergillus fumigatus isoenzymes CYP51A and CYP51B. |
| AID518662 | Antimicrobial activity against Cryptococcus gattii serotype B isolate RB22 assessed as heteroresistant isolates at 8 ug/ml | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Heteroresistance of Cryptococcus gattii to fluconazole. |
| AID1205754 | Antifungal activity against Cryptococcus gattii 23/10993 after 72 hrs by microdilution method | 2015 | ACS medicinal chemistry letters, Mar-12, Volume: 6, Issue:3 | Synthesis of a New Peptide-Coumarin Conjugate: A Potential Agent against Cryptococcosis. |
| AID563002 | Antifungal activity against Candida albicans isolate 03-2718 after 48 hrs | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | Efficacy of albaconazole against Candida albicans in a vaginitis model. |
| AID1689215 | Antifungal activity against Candida glabrata ATCC 66032 assessed as reduction in fungal growth incubated for 24 hrs by CLSI based broth microdilution method | 2020 | European journal of medicinal chemistry, Mar-01, Volume: 189 | Oxadiazolylthiazoles as novel and selective antifungal agents. |
| AID563119 | Antifungal activity against Candida glabrata ATCC 90030 after 48 hrs by broth microdilution method in presence of 0.02% glucose | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | T-2307 shows efficacy in a murine model of Candida glabrata infection despite in vitro trailing growth phenomena. |
| AID1380521 | Antifungal activity against Candida krusei MTCC 9215 assessed as inhibition of fungal growth incubated for 48 hrs by broth microdilution assay | 2018 | Bioorganic & medicinal chemistry letters, 06-01, Volume: 28, Issue:10 | Biofilm inhibition and anti-Candida activity of a cationic lipo-benzamide molecule with twin-nonyl chain. |
| AID1494150 | Antifungal activity against Candida krusei after 5 to 7 days | 2018 | European journal of medicinal chemistry, Jan-01, Volume: 143 | Molecular docking, design, synthesis and antifungal activity study of novel triazole derivatives. |
| AID1300879 | Antifungal activity against Candida glabrata clinical isolate after 24 hrs by broth microdilution method | 2016 | European journal of medicinal chemistry, Jul-19, Volume: 117 | Novel 1,3-thiazolidin-4-one derivatives as promising anti-Candida agents endowed with anti-oxidant and chelating properties. |
| AID1419533 | Hemolytic activity in mouse erythrocytes assessed as hemolysis level at 3.9 ug/ml incubated for 1 hr at 37 degC | 2017 | European journal of medicinal chemistry, Jun-16, Volume: 133 | Novel alkylated azoles as potent antifungals. |
| AID531463 | Antifungal activity against Candida tropicalis assessed as susceptible dose-dependent isolates after 48 hrs by CLSI method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | In vitro susceptibilities of invasive isolates of Candida species: rapid increase in rates of fluconazole susceptible-dose dependent Candida glabrata isolates. |
| AID1157163 | Antifungal activity against Cryptococcus neoformans PMC 2123 after 72 hrs by CLSI broth microdilution method | 2014 | European journal of medicinal chemistry, Aug-18, Volume: 83 | Synthesis, biological evaluation and structure-activity correlation study of a series of imidazol-based compounds as Candida albicans inhibitors. |
| AID1904394 | Cytotoxicity against human MCF7 cells assessed as reduction in cell viability incubated for 96 hrs by MTT assay | 2022 | European journal of medicinal chemistry, Apr-05, Volume: 233 | Design, synthesis, and evaluation of novel 3-thiophene derivatives as potent fungistatic and fungicidal reagents based on a conformational restriction strategy. |
| AID1918387 | Anti-inflammatory activity in mouse infected with Candida albicans assessed as reduction in NLRP3 expression in infection tissues at 20 mg/kg, ip administered on days 2,4,6,8,10,12 and measured on day 14 by western blot analysis | 2022 | Journal of medicinal chemistry, 11-10, Volume: 65, Issue:21 | Novel Aryl Alkamidazole Derivatives as Multifunctional Antifungal Inhibitors: Design, Synthesis, and Biological Evaluation. |
| AID625833 | Antifungal activity against Trichophyton mentagrophytes by broth microdilution method | 2011 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 21, Issue:21 | Micelles catalyzed chemoselective synthesis 'in water' and biological evaluation of oxygen containing hetero-1,4-naphthoquinones as potential antifungal agents. |
| AID1707486 | Antifungal activity against Candida albicans 10061 incubated for 48 hrs by microdilution assay | 2021 | Journal of medicinal chemistry, 01-28, Volume: 64, Issue:2 | Novel Carboline Fungal Histone Deacetylase (HDAC) Inhibitors for Combinational Treatment of Azole-Resistant Candidiasis. |
| AID518878 | Antimicrobial activity against Cryptococcus gattii serotype C isolate H0058-1-1686 assessed as heteroresistant isolates at 16 ug/ml | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Heteroresistance of Cryptococcus gattii to fluconazole. |
| AID744031 | Antifungal activity against Candida albicans ATCC 10231 assessed as growth inhibition after 24 hrs by microbroth dilution method | 2013 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 23, Issue:8 | Synthesis and antimicrobial activity of polyhalo isophthalonitrile derivatives. |
| AID1295979 | Antimicrobial activity against Candida parapsilosis ATCC 22019 after 24 hrs by two fold serial dilution method | 2016 | Journal of natural products, Feb-26, Volume: 79, Issue:2 | Antifungal Quinoline Alkaloids from Waltheria indica. |
| AID542085 | Antifungal activity against Candida glabrata IFO0622 after 24 hrs by microdilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Discovery of a small-molecule inhibitor of {beta}-1,6-glucan synthesis. |
| AID555817 | Antifungal activity against cdr2/cdr2 deficient Candida albicans STY7 after 48 hrs | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Relative contributions of the Candida albicans ABC transporters Cdr1p and Cdr2p to clinical azole resistance. |
| AID682797 | Antifungal activity against Trichophyton mentagrophytes after 96 hrs by broth microdilution method | 2012 | European journal of medicinal chemistry, Oct, Volume: 56 | Micelles catalyzed chemo- and regio-selective one pot and one step synthesis of 2,3,5,6-tetrakis(alkyl and arylsulfanyl)-1,4-benzoquinones and 2,5-diaminosubstituted-1,4-benzoquinones "In-Water" and their biological evaluation as antibacterial and antifun |
| AID419071 | Antifungal activity against Candida albicans SANK 51486 | 2009 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 19, Issue:7 | Amide analogs of antifungal dioxane-triazole derivatives: synthesis and in vitro activities. |
| AID424901 | Antimicrobial activity against azole-resistant Candida albicans isolate CA10 assessed as growth at 0.5 ug/ml cotreated with 0.008 ug/ml calcineurin signaling inhibitor tacrolimus after 48 hrs by microdilution checkerboard technique relative to control | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | In vitro interactions between tacrolimus and azoles against Candida albicans determined by different methods. |
| AID42855 | Inhibition of Candida albicans ATCC 44859 growth for 24 hours in vitro. | 2001 | Journal of medicinal chemistry, Aug-16, Volume: 44, Issue:17 | 3-Phenyl-5-acyloxymethyl-2H,5H-furan-2-ones: synthesis and biological activity of a novel group of potential antifungal drugs. |
| AID1311355 | Antifungal activity against Candida albicans by broth dilution method | 2016 | Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15 | Synthesis and antimicrobial evaluation of novel ethyl 2-(2-(4-substituted)acetamido)-4-subtituted-thiazole-5-carboxylate derivatives. |
| AID584407 | Antifungal activity against 7 days cultured Candida glabrata isolated from neutropenic subject with AML or MDS stool receiving antifungal therapy for 37 days after 9 days of prophylaxis by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Impact of antifungal prophylaxis on colonization and azole susceptibility of Candida species. |
| AID1551787 | Antifungal activity against Candida albicans | 2019 | European journal of medicinal chemistry, Jul-01, Volume: 173 | Antibacterial activity study of 1,2,4-triazole derivatives. |
| AID1689816 | Antifungal activity against fluconazole-susceptible Candida albicans CAAL93 assessed as reduction in microbial growth after 24 hrs by resazurin staining based spectrofluorometric method | 2020 | European journal of medicinal chemistry, Mar-01, Volume: 189 | New azole antifungals with a fused triazinone scaffold. |
| AID519069 | Antifungal activity against Candida albicans ATCC 3153 in vitro pharmacokinetic-pharmacodynamic model | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | Mechanism-based pharmacokinetic-pharmacodynamic models of in vitro fungistatic and fungicidal effects against Candida albicans. |
| AID1067042 | Antifungal activity against Microsporum gypseum by micro-broth dilution method | 2014 | European journal of medicinal chemistry, Mar-03, Volume: 74 | Synthesis, antifungal activities and molecular docking studies of novel 2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propyl dithiocarbamates. |
| AID772328 | Antifungal activity against fluconazole-resistant Candida albicans DSY296 harboring ERG11 gene mutant and increase expressing of CDR1 and CDR2 genes after 24 hrs by visually and spectrophotometric analysis | 2013 | ACS medicinal chemistry letters, Sep-12, Volume: 4, Issue:9 | Novel Macrocyclic Amidinoureas: Potent Non-Azole Antifungals Active against Wild-Type and Resistant Candida Species. |
| AID1911626 | Antifungal activity against Aspergillus fumigatus AF293 assessed as fungal growth inhibition by broth microdilution assay | 2022 | Journal of medicinal chemistry, 06-09, Volume: 65, Issue:11 | Development of Lipo-γ-AA Peptides as Potent Antifungal Agents. |
| AID1904364 | Antifungal activity against FLC and ITC-resistant Candida albicans 17 assessed as fungal growth inhibition by CLSI based serial microbroth dilution method | 2022 | European journal of medicinal chemistry, Apr-05, Volume: 233 | Design, synthesis, and evaluation of novel 3-thiophene derivatives as potent fungistatic and fungicidal reagents based on a conformational restriction strategy. |
| AID1331131 | Antifungal activity against planktonic cells of Candida albicans ATCC 10231 after 48 hrs by microdilution assay | |||
| AID598296 | Antimicrobial activity against Candida parapsilosis isolate 26 after 48 hrs by microdilution broth method | 2011 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 21, Issue:11 | Synthesis and in vitro antimicrobial activities of new (cyano-NNO-azoxy)pyrazole derivatives. |
| AID670399 | Antifungal activity against Candida albicans MTCC 1637 by well diffusion method | 2012 | Bioorganic & medicinal chemistry letters, Jul-15, Volume: 22, Issue:14 | Synthesis, biological evaluation of 5-carbomethoxymethyl-7-hydroxy-2-pentylchromone, 5-carboethoxymethyl-4',7-dihydroxyflavone and their analogues. |
| AID625284 | Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for hepatic failure | 2011 | PLoS computational biology, Dec, Volume: 7, Issue:12 | Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). |
| AID1348090 | Antimicrobial activity against Escherichia coli ATCC 25922 assessed as zone of inhibition at 50 ug per disc after 24 hrs by disc diffusion assay | 2018 | European journal of medicinal chemistry, Jan-01, Volume: 143 | Synthesis of new 1-benzyl tetrahydropyridinylidene ammonium salts and their antimicrobial and anticellular activities. |
| AID301025 | Antifungal activity against Candida albicans after 48 hrs by agar well diffusion technique | 2007 | Bioorganic & medicinal chemistry letters, Oct-01, Volume: 17, Issue:19 | Synthesis and antimicrobial evaluation of new chalcones containing piperazine or 2,5-dichlorothiophene moiety. |
| AID1624180 | Antifungal activity against Candida albicans NR-29442 after 24 hrs by microbroth dilution method | 2019 | Bioorganic & medicinal chemistry letters, 03-01, Volume: 29, Issue:5 | Benzimidazole tethered pyrrolo[3,4-b]quinoline with broad-spectrum activity against fungal pathogens. |
| AID516268 | Antimicrobial activity against Cryptococcus gattii serotype B isolate NIH767 assessed as concentration required for heteroresistance | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Heteroresistance of Cryptococcus gattii to fluconazole. |
| AID1242650 | Antifungal activity against Aspergillus fumigatus after 16 hrs by microtiter broth dilution method | 2015 | ACS medicinal chemistry letters, Jul-09, Volume: 6, Issue:7 | Novel Chalcone-Thiazole Hybrids as Potent Inhibitors of Drug Resistant Staphylococcus aureus. |
| AID644837 | Antifungal activity against Candida tropicalis after 48 hrs by M27-A3 CLSI method | 2012 | European journal of medicinal chemistry, Mar, Volume: 49 | Synthesis and antifungal activity of a new series of 2-(1H-imidazol-1-yl)-1-phenylethanol derivatives. |
| AID619184 | Antifungal activity against Candida albicans VB 1723 by broth dilution method | 2011 | Journal of medicinal chemistry, Oct-13, Volume: 54, Issue:19 | High-throughput-screening-based identification and structure-activity relationship characterization defined (S)-2-(1-aminoisobutyl)-1-(3-chlorobenzyl)benzimidazole as a highly antimycotic agent nontoxic to cell lines. |
| AID1061246 | Antimicrobial activity against Aspergillus flavus at 1 mg/ml by well plate method | 2014 | European journal of medicinal chemistry, Jan, Volume: 71 | Synthesis and biological evaluation of novel substituted 1,3,4-thiadiazole and 2,6-di aryl substituted imidazo [2,1-b] [1,3,4] thiadiazole derivatives. |
| AID1770940 | Antifungal activity against Cryptococcus neoformans CGMCC2.3161 assessed as fungal growth inhibition by CLSI protocol based method | 2021 | European journal of medicinal chemistry, Dec-05, Volume: 225 | Design, synthesis and evaluation of novel 5-phenylthiophene derivatives as potent fungicidal of Candida albicans and antifungal reagents of fluconazole-resistant fungi. |
| AID293383 | Antifungal activity against Torulopsis glabrata by micro-broth dilution method | 2007 | European journal of medicinal chemistry, Aug, Volume: 42, Issue:8 | Synthesis and evaluation of novel 1-(1H-1,2,4-triazol-1-yl)-2-(2,4-difluorophenyl)-3-[(4-substitutedphenyl)-piperazin-1-yl]-propan-2-ols as antifungal agents. |
| AID1598020 | Antifungal activity against Fonsecaea compacta after 24 hrs by microbroth dilution method | 2019 | European journal of medicinal chemistry, May-15, Volume: 170 | Current advances of triazole alcohols derived from fluconazole: Design, in vitro and in silico studies. |
| AID1190606 | Antimicrobial activity against Escherichia coli ATCC 10536 assessed as inhibition of microbial growth incubated for 24 hrs by broth dilution method | 2015 | Bioorganic & medicinal chemistry letters, Feb-15, Volume: 25, Issue:4 | Synthesis, antimicrobial activity and molecular docking of novel tetracyclic scaffolds incorporating a flavonoid framework with medium sized oxygen heterocycles. |
| AID521990 | Antibacterial activity against Fluconazole resistant Candida albicans DSY3706 containing tac1delta/delta ERG11-1/ERG11-1 genotype infected in BALB/c mouse administered intraperitoneally 1 hr post bacterial challenge measured 3 days post infection | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Genetic dissection of azole resistance mechanisms in Candida albicans and their validation in a mouse model of disseminated infection. |
| AID606216 | Antifungal activity against Aspergillus fumigatus after 7 days by micro-broth dilution method | 2011 | European journal of medicinal chemistry, Jul, Volume: 46, Issue:7 | Design, synthesis and antifungal activities of novel 1,2,4-triazole derivatives. |
| AID1411857 | Antifungal activity against Candida albicans ATCC 90028 by CLSI protocol based broth microdilution method | 2017 | MedChemComm, Dec-01, Volume: 8, Issue:12 | Synergistic antifungal effect of cyclized chalcone derivatives and fluconazole against |
| AID1205756 | Antifungal activity against fluconazole-resistant Cryptococcus gattii L27/01F after 72 hrs by microdilution method | 2015 | ACS medicinal chemistry letters, Mar-12, Volume: 6, Issue:3 | Synthesis of a New Peptide-Coumarin Conjugate: A Potential Agent against Cryptococcosis. |
| AID1738746 | Inhibition of CYP51 in azole-resistant Candida albicans ATCC SC531 assessed as Eburicol level at 2 ug/ml incubated for 16 hrs by LC-MS analysis relative to control | 2020 | European journal of medicinal chemistry, Jul-15, Volume: 198 | Design, synthesis, and biological evaluation of novel miconazole analogues containing selenium as potent antifungal agents. |
| AID582240 | Antifungal activity against Candida albicans isolated from HSCT recipients with acute or chronic GVHD prior to initiation of fluconazole therapy assessed as maximum MIC by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Impact of antifungal prophylaxis on colonization and azole susceptibility of Candida species. |
| AID1493831 | Antifungal activity against Aspergillus fumigatus 07544 after 24 hrs by spectrophotometric analysis | 2018 | European journal of medicinal chemistry, Jan-01, Volume: 143 | Discovery of simplified sampangine derivatives as novel fungal biofilm inhibitors. |
| AID49648 | In vitro antifungal activity against Candida albicans (CY1002) in YNBPB medium | 2003 | Bioorganic & medicinal chemistry letters, Jan-06, Volume: 13, Issue:1 | Design and synthesis of novel benzofurans as a new class of antifungal agents targeting fungal N-myristoyltransferase. Part 3. |
| AID1598047 | Antifungal activity against Candida albicans Y0109 after 24 hrs | 2019 | European journal of medicinal chemistry, May-15, Volume: 170 | Current advances of triazole alcohols derived from fluconazole: Design, in vitro and in silico studies. |
| AID47586 | Evaluation of In vitro antifungal activity against Candida albicans C56 by broth macro dilution method | 1995 | Journal of medicinal chemistry, Sep-29, Volume: 38, Issue:20 | Synthesis and antifungal activity of new azole derivatives containing an N-acylmorpholine ring. |
| AID582795 | Antifungal activity against Candida albicans isolate 1008 harboring ERG3 K97E, L193P, V237A, A351V, A353T and ERG11 E266D mutant genes assessed as eburicol content in total sterol composition at 0.5 times MIC by GC-MS analysis | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | Identification and characterization of four azole-resistant erg3 mutants of Candida albicans. |
| AID531465 | Antifungal activity against Candida guilliermondii assessed as susceptible dose-dependent isolates after 48 hrs by CLSI method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | In vitro susceptibilities of invasive isolates of Candida species: rapid increase in rates of fluconazole susceptible-dose dependent Candida glabrata isolates. |
| AID1059345 | Antifungal activity against Candida glabrata after 20 hrs by agar dilution method | 2013 | European journal of medicinal chemistry, , Volume: 70 | Designing and synthesis of novel antimicrobial heterocyclic analogs of fatty acids. |
| AID1904289 | Inhibition of Cryptococcus neoformans H99 delta5,6-desaturase assessed as upregulation of ERG5 gene expression at 2 ug/ml incubated for 24 hrs by RT-PCR analysis | 2022 | Journal of medicinal chemistry, 05-12, Volume: 65, Issue:9 | Discovery of Novel Sertraline Derivatives as Potent Anti- |
| AID405052 | Antifungal activity against Sporothrix schenckii PGAC0016 isolate from cutaneous-lymphatic sporotrichosis patient after 72 hrs by Sensititre YeastOne method | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | In vitro susceptibility of Sporothrix schenckii to six antifungal agents determined using three different methods. |
| AID446448 | Antifungal activity against fluconazole-resistant Candida parapsilosis Rolland | 2009 | Bioorganic & medicinal chemistry letters, Oct-15, Volume: 19, Issue:20 | Design of new antifungal agents: synthesis and evaluation of 1-[(1H-indol-5-ylmethyl)amino]-2-phenyl-3-(1H-1,2,4-triazol-1-yl)propan-2-ols. |
| AID1155874 | Antifungal activity against Trichophyton rubrum assessed as growth inhibition by serial dilution method | 2014 | European journal of medicinal chemistry, Jul-23, Volume: 82 | Design, synthesis and antifungal activity of novel triazole derivatives containing substituted 1,2,3-triazole-piperdine side chains. |
| AID1474167 | Liver toxicity in human assessed as induction of drug-induced liver injury by measuring verified drug-induced liver injury concern status | 2016 | Drug discovery today, Apr, Volume: 21, Issue:4 | DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. |
| AID1444338 | Antifungal activity against Candida tropicalis 156 after 24 hrs by broth microdilution method | 2017 | European journal of medicinal chemistry, Apr-21, Volume: 130 | Structure-activity relationship studies on 3,5-dinitrophenyl tetrazoles as antitubercular agents. |
| AID531251 | Antifungal activity against Candida guilliermondii assessed as resistant isolates after 48 hrs by CLSI method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | In vitro susceptibilities of invasive isolates of Candida species: rapid increase in rates of fluconazole susceptible-dose dependent Candida glabrata isolates. |
| AID371228 | Antimicrobial activity against Candida albicans TIMM 3164 by broth microdilution method | 2008 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 18, Issue:24 | Carbon analogs of antifungal dioxane-triazole derivatives: synthesis and in vitro activities. |
| AID480480 | Antifungal activity against Aspergillus fumigatus after 7 days by serial dilution method | 2010 | Bioorganic & medicinal chemistry letters, May-01, Volume: 20, Issue:9 | Structure-based rational design, synthesis and antifungal activity of oxime-containing azole derivatives. |
| AID622962 | Antifungal activity against Candida albicans ATCC 90028 after 48 hrs by microdilution method | 2011 | Bioorganic & medicinal chemistry letters, Oct-15, Volume: 21, Issue:20 | Synthesis and biological activity of desmethoxy analogues of coruscanone A. |
| AID424909 | Antimicrobial activity against azole-resistant Candida albicans isolate CA10 assessed as growth at 128 ug/ml cotreated with 0.008 ug/ml calcineurin signaling inhibitor Tacrolimus after 48 hrs by microdilution checkboard technique relative to control | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | In vitro interactions between tacrolimus and azoles against Candida albicans determined by different methods. |
| AID565404 | Antifungal activity against Rhizopus microsporus IHEM 5234 by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Correlation of in vitro activity, serum levels, and in vivo efficacy of posaconazole against Rhizopus microsporus in a murine disseminated infection. |
| AID1059361 | Fungicidal activity against Candida albicans by micro dilution method | 2013 | European journal of medicinal chemistry, , Volume: 70 | Designing and synthesis of novel antimicrobial heterocyclic analogs of fatty acids. |
| AID1818282 | Induction of apoptosis against Candida albicans ATCC SC5314 assessed as necrotic cells measured after 48 hrs by by Annexin V-FITC/propidium iodide staining based flow cytometry (Rvb = 18.22 %) | |||
| AID555135 | Antimicrobial activity against Candida albicans by EUCAST broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Fenticonazole activity measured by the methods of the European Committee on Antimicrobial Susceptibility Testing and CLSI against 260 Candida vulvovaginitis isolates from two European regions and annotations on the prevalent genotypes. |
| AID1872500 | Antifungal activity against Candida glabrata | 2022 | European journal of medicinal chemistry, Mar-05, Volume: 231 | Synthetic approaches and structural diversity of triazolylbutanols derived from voriconazole in the antifungal drug development. |
| AID304972 | Antifungal activity against Candida albicans by broth micro-dilution technique | 2007 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 17, Issue:1 | New antifungal flavonoid glycoside from Vitex negundo. |
| AID426130 | Antimicrobial activity against Candida tropicalis ATCC 13803 at 5 ug after 18 hrs by agar-well diffusion assay | 2009 | European journal of medicinal chemistry, Jul, Volume: 44, Issue:7 | Synthesis of some new 1,3,4-thiadiazol-2-ylmethyl-1,2,4-triazole derivatives and investigation of their antimicrobial activities. |
| AID1758035 | Inhibition of CYP51 in Candida albicans ATCC SC5314 assessed as Obtusifoliol level at 8 ug/ml after 16 hrs by GC-MS analysis (Rvb = 0%) | 2021 | European journal of medicinal chemistry, Apr-15, Volume: 216 | Lead optimization generates selenium-containing miconazole CYP51 inhibitors with improved pharmacological profile for the treatment of fungal infections. |
| AID1309045 | Antifungal activity against clinical isolates of Candida albicans SC5314 after 48 hrs by broth microdilution method | 2016 | Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15 | Synthesis of riccardin D derivatives as potent antimicrobial agents. |
| AID262557 | Antifungal activity against Trichophyton mentagrophytes | 2006 | Journal of medicinal chemistry, Apr-20, Volume: 49, Issue:8 | Structure-based optimization of azole antifungal agents by CoMFA, CoMSIA, and molecular docking. |
| AID1877281 | Antifungal activity against Candida tropicalis CGMCC 2.3739 assessed as fungal growth inhibition by NCCLS protocol based method | 2022 | European journal of medicinal chemistry, Jan-05, Volume: 227 | Broadening antifungal spectrum and improving metabolic stablity based on a scaffold strategy: Design, synthesis, and evaluation of novel 4-phenyl-4,5-dihydrooxazole derivatives as potent fungistatic and fungicidal reagents. |
| AID27575 | HPLC capacity factor (k) | 2000 | Journal of medicinal chemistry, Jul-27, Volume: 43, Issue:15 | ElogPoct: a tool for lipophilicity determination in drug discovery. |
| AID566882 | Antifungal activity against Cryptococcus neoformans by microdilution test | 2011 | European journal of medicinal chemistry, Jan, Volume: 46, Issue:1 | Synthesis and antifungal activity of some substituted phenothiazines and related compounds. |
| AID1592341 | Antifungal activity against Candida albicans ATCC 7754 after 72 hrs by agar dilution method | 2019 | European journal of medicinal chemistry, Apr-01, Volume: 167 | Efficient click chemistry towards novel 1H-1,2,3-triazole-tethered 4H-chromene-d-glucose conjugates: Design, synthesis and evaluation of in vitro antibacterial, MRSA and antifungal activities. |
| AID1694054 | Antifungal activity against Candida albicans CS35 assessed as diameter of zone inhibition at 5 mg/ml incubated for 24 hrs by agar plate diffusion method | 2021 | Bioorganic & medicinal chemistry, 02-01, Volume: 31 | Synthesis, anticancer and antimicrobial evaluation of new benzofuran based derivatives: PI3K inhibition, quorum sensing and molecular modeling study. |
| AID1546137 | Antifungal activity against Candida albicans ATCC 76615 after 24 hrs | 2019 | European journal of medicinal chemistry, Dec-15, Volume: 184 | Current scenario of tetrazole hybrids for antibacterial activity. |
| AID1556222 | Inhibition of CYP51 in Candida albicans ATCC SC5314 assessed as obtusifoliol level at 8 ug/ml incubated for 16 hrs by GC/MS analysis (Rvb = 0%) | 2019 | European journal of medicinal chemistry, Sep-01, Volume: 177 | Design, synthesis, and structure-activity relationship studies of l-amino alcohol derivatives as broad-spectrum antifungal agents. |
| AID516301 | Antimicrobial activity against fluconazole-resistant Cryptococcus gattii serotype B isolate RAM15 at 256 ug/ml | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Heteroresistance of Cryptococcus gattii to fluconazole. |
| AID27167 | Delta logD (logD6.5 - logD7.4) | 2000 | Journal of medicinal chemistry, Jun-29, Volume: 43, Issue:13 | QSAR model for drug human oral bioavailability. |
| AID477308 | Antifungal activity against Microsporum gypseum after 1 to 7 days by twofold serial dilution method | 2010 | European journal of medicinal chemistry, Apr, Volume: 45, Issue:4 | Synthesis and in vitro microbiological evaluation of an array of biolabile 2-morpholino-N-(4,6-diarylpyrimidin-2-yl)acetamides. |
| AID48574 | Minimum concentration required to inhibit the growth of Candida albicans TIMM3164 was determined | 2002 | Bioorganic & medicinal chemistry letters, Oct-07, Volume: 12, Issue:19 | Synthesis and evaluation of novel pyrrolidinyl sordaricin derivatives as antifungal agents. |
| AID594940 | Antimicrobial activity against Trichophyton rubrum after 7 days by NCCLS method | 2011 | European journal of medicinal chemistry, May, Volume: 46, Issue:5 | Design and synthesis of antifungal benzoheterocyclic derivatives by scaffold hopping. |
| AID1201638 | Antimicrobial activity against Candida albicans ATCC 12031 after 48 hrs by two-fold serial dilution method | 2015 | European journal of medicinal chemistry, May-05, Volume: 95 | Synthesis, biological evaluation and molecular docking of some substituted pyrazolines and isoxazolines as potential antimicrobial agents. |
| AID453442 | Antifungal activity against Candida albicans ATCC 24433 after 48 hrs by broth microdilution method | 2010 | Bioorganic & medicinal chemistry letters, Jan-15, Volume: 20, Issue:2 | Fluconazole analogues containing 2H-1,4-benzothiazin-3(4H)-one or 2H-1,4-benzoxazin-3(4H)-one moieties, a novel class of anti-Candida agents. |
| AID566880 | Antifungal activity against Candida krusei by microdilution test | 2011 | European journal of medicinal chemistry, Jan, Volume: 46, Issue:1 | Synthesis and antifungal activity of some substituted phenothiazines and related compounds. |
| AID1193899 | Antifungal activity against Candida albicans MTCC 461 assessed as zone of inhibition at 5 mg/ml after 24 hrs by agar well diffusion method | 2015 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 25, Issue:7 | Rapid 'one-pot' synthesis of a novel benzimidazole-5-carboxylate and its hydrazone derivatives as potential anti-inflammatory and antimicrobial agents. |
| AID494614 | Antifungal activity against Saccharomyces cerevisiae KE743 overexpressing GWT1 after 2 days by broth-microdilution method | 2010 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 20, Issue:15 | Synthesis and evaluation of novel antifungal agents-quinoline and pyridine amide derivatives. |
| AID531246 | Antifungal activity against Candida lusitaniae assessed as susceptible isolates after 48 hrs by CLSI method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | In vitro susceptibilities of invasive isolates of Candida species: rapid increase in rates of fluconazole susceptible-dose dependent Candida glabrata isolates. |
| AID670394 | Antifungal activity against Candida albicans MTCC 4748 by well diffusion method | 2012 | Bioorganic & medicinal chemistry letters, Jul-15, Volume: 22, Issue:14 | Synthesis, biological evaluation of 5-carbomethoxymethyl-7-hydroxy-2-pentylchromone, 5-carboethoxymethyl-4',7-dihydroxyflavone and their analogues. |
| AID516306 | Antimicrobial activity against Cryptococcus gattii serotype B isolate NIH281 assessed as concentration required for heteroresistance | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Heteroresistance of Cryptococcus gattii to fluconazole. |
| AID1595049 | Antifungal activity against Candida tropicalis assessed as reduction in fungal cell growth incubated for 48 hrs by broth microdilution method | 2019 | European journal of medicinal chemistry, May-15, Volume: 170 | Tetrazole hybrids and their antifungal activities. |
| AID457998 | Antifungal activity against Absidia corymbifera 272 after 48 hrs by microdilution method | 2010 | Bioorganic & medicinal chemistry, Mar-01, Volume: 18, Issue:5 | Antifungal 3,5-disubstituted furanones: From 5-acyloxymethyl to 5-alkylidene derivatives. |
| AID644835 | Antifungal activity against Candida parapsilosis ATCC 22019 after 48 hrs by M27-A3 CLSI method | 2012 | European journal of medicinal chemistry, Mar, Volume: 49 | Synthesis and antifungal activity of a new series of 2-(1H-imidazol-1-yl)-1-phenylethanol derivatives. |
| AID666599 | Antifungal activity against Candida albicans after 16 hrs by broth dilution method | 2012 | European journal of medicinal chemistry, Aug, Volume: 54 | Facile synthesis, cytotoxic and antimicrobial activity studies of a new group of 6-aryl-3-[4-(methylsulfonyl)benzyl]-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazines. |
| AID644772 | Antifungal activity against Candida parapsilosis ATCC 22019 after 48 hrs by broth microdilution method | 2012 | European journal of medicinal chemistry, Mar, Volume: 49 | New heterocyclic compounds from 1,2,4-triazole and 1,3,4-thiadiazole class bearing diphenylsulfone moieties. Synthesis, characterization and antimicrobial activity evaluation. |
| AID1391314 | Antibacterial activity against Streptococcus mutans 3289 after 24 hrs by two-fold serial dilution method | 2018 | Bioorganic & medicinal chemistry letters, 05-15, Volume: 28, Issue:9 | Synthesis and evaluation of the antibacterial activities of aryl substituted dihydrotriazine derivatives. |
| AID372256 | Fungicidal activity against Candida albicans CHK23 assessed as reduction in cell viability at MIC of SSK21/CHK21 after 24 hrs | 2007 | Antimicrobial agents and chemotherapy, Oct, Volume: 51, Issue:10 | The Ssk1p response regulator and Chk1p histidine kinase mutants of Candida albicans are hypersensitive to fluconazole and voriconazole. |
| AID518658 | Antimicrobial activity against Cryptococcus gattii serotype B isolate NIH367 assessed as heteroresistant isolates at 8 ug/ml | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Heteroresistance of Cryptococcus gattii to fluconazole. |
| AID1265387 | Antifungal activity against Candida albicans SC5314 by broth microdilution method | 2015 | Journal of natural products, Nov-25, Volume: 78, Issue:11 | Bioactive ent-Pimarane and ent-Abietane Diterpenoids from the Whole Plants of Chloranthus henryi. |
| AID1742148 | Inhibition of CYP51 in Candida albicans ATCC SC5314 assessed as squalene level at 4 ug/ml incubated for 16 hrs by LC/MS analysis (Rvb = 2.25 %) | 2020 | European journal of medicinal chemistry, Nov-01, Volume: 205 | Design, synthesis and bioactivity evaluation of novel arylalkene-amide derivatives as dual-target antifungal inhibitors. |
| AID269979 | Antifungal activity against Aspergillus fumigatus ATCC 64026 | 2006 | Journal of medicinal chemistry, Aug-10, Volume: 49, Issue:16 | Synthesis and antifungal activity of a novel series of alkyldimethylamine cyanoboranes and their derivatives. |
| AID1351907 | Antifungal activity against Candida albicans ATCC 90028 after 48 hrs by M27-A3 microdilution method | 2018 | European journal of medicinal chemistry, Feb-10, Volume: 145 | New 1,5 and 2,5-disubstituted tetrazoles-dependent activity towards surface barrier of Candida albicans. |
| AID1609926 | Antifungal activity against Candida albicans GIM 2.194 assessed as reduction in fungal growth incubated for 24 hrs by serial dilution method | |||
| AID47890 | Evaluation of In vitro antifungal activity against Candida parapsilosis C74 by broth macro dilution method | 1995 | Journal of medicinal chemistry, Sep-29, Volume: 38, Issue:20 | Synthesis and antifungal activity of new azole derivatives containing an N-acylmorpholine ring. |
| AID478533 | Antimicrobial activity against Candida tropicalis ATCC 1369 after 24 hrs by broth microdilution assay | 2010 | European journal of medicinal chemistry, May, Volume: 45, Issue:5 | Synthesis of some novel 2-substituted-5-[isopropylthiazole] clubbed 1,2,4-triazole and 1,3,4-oxadiazoles as potential antimicrobial and antitubercular agents. |
| AID1205748 | Antifungal activity against Cryptococcus gattii ATCC 24065 after 72 hrs by microdilution method | 2015 | ACS medicinal chemistry letters, Mar-12, Volume: 6, Issue:3 | Synthesis of a New Peptide-Coumarin Conjugate: A Potential Agent against Cryptococcosis. |
| AID1268014 | Antifungal activity against Aspergillus flavus assessed as growth inhibition incubated for 72 hrs at 37 degC by broth dilution method | 2016 | Bioorganic & medicinal chemistry letters, Jan-15, Volume: 26, Issue:2 | Synthesis of novel coumarin appended bis(formylpyrazole) derivatives: Studies on their antimicrobial and antioxidant activities. |
| AID1770931 | Ratio of MFC for fungicidal activity against Candida albicans ATCC SC5314 to MIC for Antifungal activity against Candida albicans ATCC SC5314 | 2021 | European journal of medicinal chemistry, Dec-05, Volume: 225 | Design, synthesis and evaluation of novel 5-phenylthiophene derivatives as potent fungicidal of Candida albicans and antifungal reagents of fluconazole-resistant fungi. |
| AID1918390 | Anti-inflammatory activity in mouse infected with Candida albicans assessed as reduction in NF-kappaB p65 expression in spleen at 20 mg/kg, ip administered on days 2,4,6,8,10,12 and measured on day 14 by immunohistochemical analysis | 2022 | Journal of medicinal chemistry, 11-10, Volume: 65, Issue:21 | Novel Aryl Alkamidazole Derivatives as Multifunctional Antifungal Inhibitors: Design, Synthesis, and Biological Evaluation. |
| AID1549136 | Antifungal activity against azole-sensitive Candida albicans SC5314 after 48 hrs by spectrophotometry-based serial microdilution method | 2020 | Journal of medicinal chemistry, 05-28, Volume: 63, Issue:10 | Discovery of Novel Fungal Lanosterol 14α-Demethylase (CYP51)/Histone Deacetylase Dual Inhibitors to Treat Azole-Resistant Candidiasis. |
| AID532951 | Antifungal activity against Candida albicans isolate V1 with CAI genotype by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | Correlation between azole susceptibilities, genotypes, and ERG11 mutations in Candida albicans isolates associated with vulvovaginal candidiasis in China. |
| AID1367158 | Antifungal activity against Trichophyton mentagrophytes 445 after 120 hrs by microdilution broth method | 2017 | Bioorganic & medicinal chemistry letters, 12-01, Volume: 27, Issue:23 | Synthesis and biological evolution of hydrazones derived from 4-(trifluoromethyl)benzohydrazide. |
| AID1918362 | Inhibition of CYP51 in Candida albicans ATCC SC5314 assessed as eburicol content at 4 ug/ml measured after 48 hrs by GC-MS analysis (Rvb = 1.84%) | 2022 | Journal of medicinal chemistry, 11-10, Volume: 65, Issue:21 | Novel Aryl Alkamidazole Derivatives as Multifunctional Antifungal Inhibitors: Design, Synthesis, and Biological Evaluation. |
| AID525413 | Antifungal activity against 2.44 x 10'8 CFU fluconazole-susceptible Candida glabrata isolate 4293 infected neutropenic CD1 mouse disseminated candidiasis model assessed as reduction in kidney tissue fungal burden at 1 mg/kg/day, ip administered 24 hrs pos | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Posaconazole against Candida glabrata isolates with various susceptibilities to fluconazole. |
| AID1309049 | Antifungal activity against Candida albicans ATCC MYA-90819 after 48 hrs by CLSI M27-A3 method | 2016 | Bioorganic & medicinal chemistry, 08-15, Volume: 24, Issue:16 | Synthesis and investigation of novel benzimidazole derivatives as antifungal agents. |
| AID582222 | Antifungal activity against Candida albicans isolated from HSCT recipients with acute or chronic GVHD prior to initiation of posaconazole therapy assessed as maximum MIC by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Impact of antifungal prophylaxis on colonization and azole susceptibility of Candida species. |
| AID1864897 | Antifungal activity against fluconazole- resistant Candida albicans 17# assessed as fungal growth inhibition measured after 72 hrs in presence of naproxen by double dilution method | |||
| AID1877836 | Antifungal activity against Candida albicans CA5408 by microdilution method | 2022 | Bioorganic & medicinal chemistry letters, 02-15, Volume: 58 | Synthesis and antifungal evaluation of phenol-derived bis(indolyl)methanes combined with FLC against Candida albicans. |
| AID1311680 | Antifungal activity against Candida albicans MTCC 3017 measured after 48 hrs by NCCL protocol based broth dilution method | 2016 | Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15 | Synthesis, characterization and antimicrobial activity of novel Schiff base tethered boronate esters of 1,2-O-isopropylidene-α-d-xylofuranose. |
| AID1754265 | Antifungal activity against clinical strain Candida parapsilosis by microplate reader assay | 2021 | Bioorganic & medicinal chemistry, 07-01, Volume: 41 | A new sulfated triterpene glycoside from the sea cucumber Colochirus quadrangularis, and evaluation of its antifungal, antitumor and immunomodulatory activities. |
| AID1864875 | Antifungal actvity against Candida albicans ATCC SC5314 infected in mouse assessed as reduction in fungal infection at 10 ug per 20 g, ip administered on day 2, 4, 6, 8, 10 and 12 and measured on day 14 | |||
| AID285867 | Antimicrobial susceptibility of Pichia anomala from nosocomial fungemia patient assessed as percent susceptible isolates at 0.25 ug/ml by EUCAST method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Antifungal drug susceptibility profile of Pichia anomala isolates from patients presenting with nosocomial fungemia. |
| AID49982 | Minimum inhibitory concentration of compound for antifungal activity against Candida glabrata | 2000 | Bioorganic & medicinal chemistry letters, Oct-02, Volume: 10, Issue:19 | Novel antifungals based on 4-substituted imidazole: a combinatorial chemistry approach to lead discovery and optimization. |
| AID405049 | Antifungal activity against Sporothrix schenckii P26187 isolate from cutaneous-lymphatic sporotrichosis patient after 72 hrs by Sensititre YeastOne method | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | In vitro susceptibility of Sporothrix schenckii to six antifungal agents determined using three different methods. |
| AID637212 | Antifungal activity against Aspergillus niger MTCC 8189 after 7 days by tube dilution method | 2012 | European journal of medicinal chemistry, Feb, Volume: 48 | Synthesis, antimicrobial, anticancer evaluation and QSAR studies of 6-methyl-4-[1-(2-substituted-phenylamino-acetyl)-1H-indol-3-yl]-2-oxo/thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid ethyl esters. |
| AID1557081 | Antifungal activity against Candida parapsilosis ATCC 90018 assessed as reduction in fungal cell growth incubated for 24 hrs by MTT based broth double dilution method | 2019 | European journal of medicinal chemistry, Oct-01, Volume: 179 | Antifungal activity, mode of action variability, and subcellular distribution of coumarin-based antifungal azoles. |
| AID1689838 | Inhibition of sterol biosynthesis in Candida albicans CAAL93 assessed as other sterols level at 10 ng/ml after 18 hrs by GC-MS analysis (Rvb < 1%) | 2020 | European journal of medicinal chemistry, Mar-01, Volume: 189 | New azole antifungals with a fused triazinone scaffold. |
| AID607121 | Antifungal activity against Candida albicans ATCC 76615 by microbroth dilution method | 2011 | Bioorganic & medicinal chemistry letters, Jul-15, Volume: 21, Issue:14 | Synthesis and activities of naphthalimide azoles as a new type of antibacterial and antifungal agents. |
| AID1309046 | Antifungal activity against Candida albicans ATCC 10231 after 48 hrs by CLSI M27-A3 method | 2016 | Bioorganic & medicinal chemistry, 08-15, Volume: 24, Issue:16 | Synthesis and investigation of novel benzimidazole derivatives as antifungal agents. |
| AID1495964 | Fungicidal activity against Trichophyton mentagrophytes measured after 96 hrs | 2018 | Bioorganic & medicinal chemistry, 07-23, Volume: 26, Issue:12 | Efficiency of newly prepared thiazole derivatives against some cutaneous fungi. |
| AID725886 | Antifungal activity against fluconazole-resistant Candida albicans DSY735 after 24 hrs by spectrofluorometric analysis | 2013 | ACS medicinal chemistry letters, Feb-14, Volume: 4, Issue:2 | Discovery of a novel broad-spectrum antifungal agent derived from albaconazole. |
| AID415949 | Antimicrobial activity against Candida albicans by micro-broth dilution method | 2009 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 19, Issue:6 | Design, synthesis, and biological evaluation of novel 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-substituted benzylamino-2-propanols. |
| AID719320 | Antimicrobial activity against Bacillus subtilis NCIM 2999 at 100 ug/mL incubated for 24 hrs by agar disc diffusion method | 2012 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 22, Issue:23 | Synthesis, characterization, antidepressant and antioxidant activity of novel piperamides bearing piperidine and piperazine analogues. |
| AID425129 | Antimicrobial activity against azole-resistant Candida albicans isolate CA10 assessed as growth at 16 ug/ml co-treated with 0.002 ug/ml calcineurin signaling inhibitor tacrolimus after 48 hrs by microdilution checkboard technique relative to control | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | In vitro interactions between tacrolimus and azoles against Candida albicans determined by different methods. |
| AID204352 | Minimum inhibitory concentration of compound for antifungal activity against Sporothrix schenck ii | 2000 | Bioorganic & medicinal chemistry letters, Oct-02, Volume: 10, Issue:19 | Novel antifungals based on 4-substituted imidazole: a combinatorial chemistry approach to lead discovery and optimization. |
| AID609978 | Antifungal activity against Penicillium notatum sp. at 500 ug after 24 hrs by paper disc technique | 2011 | Bioorganic & medicinal chemistry letters, Aug-15, Volume: 21, Issue:16 | Efficient synthesis of antifungal active 9-substituted-3-aryl-5H,13aH-quinolino[3,2-f][1,2,4]triazolo[4,3-b][1,2,4]triazepines in ionic liquids. |
| AID1439294 | Antifungal activity against Candida albicans at 100 ug/ml by disc diffusion method | 2017 | European journal of medicinal chemistry, Mar-10, Volume: 128 | Tetrazolylmethyl quinolines: Design, docking studies, synthesis, anticancer and antifungal analyses. |
| AID518665 | Antimicrobial activity against Cryptococcus gattii serotype B isolate B5763 assessed as heteroresistant isolates at 8 ug/ml | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Heteroresistance of Cryptococcus gattii to fluconazole. |
| AID544874 | Antimicrobial activity against Candida dubliniensis harboring MRR1 CM2 mutant gene by microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | Gain-of-function mutations in the transcription factor MRR1 are responsible for overexpression of the MDR1 efflux pump in fluconazole-resistant Candida dubliniensis strains. |
| AID1695846 | Antibacterial activity against Aspergillus niger MTCC 8189 by serial dilution method | 2019 | European journal of medicinal chemistry, Apr-15, Volume: 168 | Comprehensive review on the anti-bacterial activity of 1,2,3-triazole hybrids. |
| AID518141 | Antimicrobial activity against Cryptococcus gattii serotype B isolate RB-35 assessed as concentration required for heteroresistance | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Heteroresistance of Cryptococcus gattii to fluconazole. |
| AID1689223 | Antifungal activity against Cryptococcus neoformans NR48770 assessed as reduction in fungal growth incubated for 48 hrs by CLSI based broth microdilution method | 2020 | European journal of medicinal chemistry, Mar-01, Volume: 189 | Oxadiazolylthiazoles as novel and selective antifungal agents. |
| AID582235 | Antifungal activity against Candida albicans isolated from neutropenic subjects with AML or MDS receiving posaconazole assessed as maximum MIC by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Impact of antifungal prophylaxis on colonization and azole susceptibility of Candida species. |
| AID510622 | Antifungal activity against Trichophyton rubrum by serial dilution method | 2010 | European journal of medicinal chemistry, Sep, Volume: 45, Issue:9 | Design, synthesis and antifungal activity of isosteric analogues of benzoheterocyclic N-myristoyltransferase inhibitors. |
| AID518426 | Antimicrobial activity against Cryptococcus gattii serotype C isolate H0058-1-818 assessed as heteroresistant isolates at 2 ug/ml | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Heteroresistance of Cryptococcus gattii to fluconazole. |
| AID743891 | Antifungal activity against Aspergillus flavus 3372 at 5 mg/mL after 48 hrs | 2013 | European journal of medicinal chemistry, May, Volume: 63 | Synthesis, antimicrobial, antiquorum-sensing, antitumor and cytotoxic activities of new series of fused [1,3,4]thiadiazoles. |
| AID762384 | Antifungal activity against Aspergillus niger ATCC 16404 after 24 to 72 hrs by microdilution method | 2013 | European journal of medicinal chemistry, Aug, Volume: 66 | Synthesis, in vitro antifungal activity and in silico study of 3-(1,2,4-triazol-1-yl)flavanones. |
| AID1738707 | Antifungal activity against Aspergillus fumigatus CGMCC 3.7795 measured after 72 hrs by micro-broth dilution assay | 2020 | European journal of medicinal chemistry, Jul-15, Volume: 198 | Design, synthesis, and biological evaluation of novel miconazole analogues containing selenium as potent antifungal agents. |
| AID428420 | Antifungal activity against Candida albicans after 48 hrs by agar dilution method | 2009 | European journal of medicinal chemistry, Jul, Volume: 44, Issue:7 | Design, synthesis, and antifungal activity of triazole and benzotriazole derivatives. |
| AID1549140 | Antifungal activity against azole-resistant Candida tropicalis 5008 after 48 hrs by spectrophotometry-based serial microdilution method | 2020 | Journal of medicinal chemistry, 05-28, Volume: 63, Issue:10 | Discovery of Novel Fungal Lanosterol 14α-Demethylase (CYP51)/Histone Deacetylase Dual Inhibitors to Treat Azole-Resistant Candidiasis. |
| AID1494146 | Antifungal activity against Cryptococcus neoformans after 72 hrs | 2018 | European journal of medicinal chemistry, Jan-01, Volume: 143 | Molecular docking, design, synthesis and antifungal activity study of novel triazole derivatives. |
| AID1864929 | Antifungal activity against Candida albicans ATCC SC5314 assessed as decrease in fungal cell density measured immediately by fluorescence microscopy (Rvb = 126%) | |||
| AID1472815 | Antifungal activity against itraconazole and fluconazole susceptible Candida albicans ATCC MYA-2876 after 48 hrs by broth dilution method | 2018 | Journal of medicinal chemistry, 01-11, Volume: 61, Issue:1 | Alkylated Piperazines and Piperazine-Azole Hybrids as Antifungal Agents. |
| AID293879 | Antifungal activity against Candida albicans CMAH 0511 after 48 to 72 hrs by broth microdilution method | 2007 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 17, Issue:6 | Synthesis of pseudopeptides based L-tryptophan as a potential antimicrobial agent. |
| AID589644 | Antifungal activity against Candida albicans | 2011 | European journal of medicinal chemistry, Apr, Volume: 46, Issue:4 | Synthesis of some novel 3-(1-(1-substitutedpiperidin-4-yl)-1H-1,2,3-triazol-4-yl)-5-substituted phenyl-1,2,4-oxadiazoles as antifungal agents. |
| AID49631 | Minimum inhibitory concentration of compound for antifungal activity against Candida albicans 1 | 2000 | Bioorganic & medicinal chemistry letters, Oct-02, Volume: 10, Issue:19 | Novel antifungals based on 4-substituted imidazole: a combinatorial chemistry approach to lead discovery and optimization. |
| AID7783 | Unbound fraction (plasma) | 2004 | Journal of medicinal chemistry, Feb-26, Volume: 47, Issue:5 | Prediction of human volume of distribution values for neutral and basic drugs. 2. Extended data set and leave-class-out statistics. |
| AID1767305 | Antifungal activity against Candida albicans assessed as fungal growth inhibition by CLSI protocol based microbroth dilution method | 2021 | European journal of medicinal chemistry, Oct-05, Volume: 221 | Discovery of novel purinylthiazolylethanone derivatives as anti-Candida albicans agents through possible multifaceted mechanisms. |
| AID719031 | Antifungal activity against Candida krusei E28 assessed as growth inhibition after 24 hrs by CLSI M27-A2 broth microdilution method | 2012 | Bioorganic & medicinal chemistry, Dec-15, Volume: 20, Issue:24 | Anti-infective and herbicidal activity of N-substituted 2-aminobenzothiazoles. |
| AID1235462 | Antifungal activity against clinical isolates of Candida tropicalis 2029 after 48 hrs by disc diffusion assay | 2015 | Bioorganic & medicinal chemistry, Aug-01, Volume: 23, Issue:15 | Imidazole clubbed 1,3,4-oxadiazole derivatives as potential antifungal agents. |
| AID467288 | Antifungal activity against Trichophyton rubrum by serial dilution method after 7 days | 2009 | Bioorganic & medicinal chemistry letters, Oct-15, Volume: 19, Issue:20 | Discovery of highly potent novel antifungal azoles by structure-based rational design. |
| AID554935 | Increase in ERG11 mRNA expression in Candida krusei B2399 at > 200 ug/ml after up to 320 mins by hot-phenol extraction based Northern blotting | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Abc1p is a multidrug efflux transporter that tips the balance in favor of innate azole resistance in Candida krusei. |
| AID555138 | Antimicrobial activity against Candida parapsilosis ATCC 22019 by EUCAST broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Fenticonazole activity measured by the methods of the European Committee on Antimicrobial Susceptibility Testing and CLSI against 260 Candida vulvovaginitis isolates from two European regions and annotations on the prevalent genotypes. |
| AID1728511 | Inhibition of CYP51 in Candida albicans ATCC SC5314 assessed as squalene level at 4 ug/ml incubated for 48 hrs by LC/MS analysis | 2021 | European journal of medicinal chemistry, Jan-15, Volume: 210 | Novel naphthylamide derivatives as dual-target antifungal inhibitors: Design, synthesis and biological evaluation. |
| AID545151 | Antimicrobial activity against Candida albicans isolate R after 48 hrs by EUCAST microdilution method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Breakthrough Aspergillus fumigatus and Candida albicans double infection during caspofungin treatment: laboratory characteristics and implication for susceptibility testing. |
| AID1759540 | Antifungal activity against Candida tropicalis | 2021 | Bioorganic & medicinal chemistry letters, 06-01, Volume: 41 | Isatin-derived azoles as new potential antimicrobial agents: Design, synthesis and biological evaluation. |
| AID598292 | Antimicrobial activity against Candida glabrata isolate 30 after 48 hrs by microdilution broth method | 2011 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 21, Issue:11 | Synthesis and in vitro antimicrobial activities of new (cyano-NNO-azoxy)pyrazole derivatives. |
| AID307398 | Antifungal activity against Candida tropicalis ATCC 750 by broth microdilution assay | 2007 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 17, Issue:12 | Discovery of novel indazole-linked triazoles as antifungal agents. |
| AID1551290 | Antibacterial activity against Staphylococcus aureus RN4220 assessed as reduction in bacterial cell growth incubated for 24 hrs by ELISA | 2019 | European journal of medicinal chemistry, Jun-15, Volume: 172 | Synthesis and biological evaluation of tryptophan-derived rhodanine derivatives as PTP1B inhibitors and anti-bacterial agents. |
| AID1598009 | Antifungal activity against Candida albicans | 2019 | European journal of medicinal chemistry, May-15, Volume: 170 | Current advances of triazole alcohols derived from fluconazole: Design, in vitro and in silico studies. |
| AID1125782 | Antibacterial activity against Escherichia coli NCIM 2931 assessed as diameter of growth inhibition zone at 10 ug/ml after 20 hrs by agar disc diffusion method | 2014 | European journal of medicinal chemistry, Apr-22, Volume: 77 | New polyfunctional imidazo[4,5-C]pyridine motifs: synthesis, crystal studies, docking studies and antimicrobial evaluation. |
| AID642922 | Antifungal activity against Aspergillus fumigatus ATCC 13073 at 160 ug/ml | 2011 | ACS medicinal chemistry letters, May-12, Volume: 2, Issue:5 | Natural Product Based 6-Hydroxy-2,3,4,6-tetrahydropyrrolo[1,2-a]pyrimidinium Scaffold as A New Antifungal Template. |
| AID1244343 | Antifungal activity against Cryptococcus neoformans incubated for 48 hrs by broth micro-dilution method | 2015 | European journal of medicinal chemistry, Aug-28, Volume: 101 | N-Alkyl/aryl-4-(3-substituted-3-phenylpropyl)piperazine-1-carbothioamide as dual-action vaginal microbicides with reverse transcriptase inhibition. |
| AID1201627 | Antimicrobial activity against Candida albicans ATCC 12031 assessed as diameter of zone of inhibition at 20 microg/disc after 24 hrs by agar well diffusion method | 2015 | European journal of medicinal chemistry, May-05, Volume: 95 | Synthesis, biological evaluation and molecular docking of some substituted pyrazolines and isoxazolines as potential antimicrobial agents. |
| AID1628383 | Antimicrobial activity against Escherichia coli JM109 incubated for 24 hrs by NCCLS protocol based method | 2016 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 26, Issue:12 | Discovery of novel berberine imidazoles as safe antimicrobial agents by down regulating ROS generation. |
| AID563610 | Effect on sterol composition in Candida albicans isolate 108 harboring erg11 and erg5 double mutant assessed as 4,14alpha-Dimethylcholesta-8,24-dienol level after 2 hrs by gas chromatography | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | A clinical isolate of Candida albicans with mutations in ERG11 (encoding sterol 14alpha-demethylase) and ERG5 (encoding C22 desaturase) is cross resistant to azoles and amphotericin B. |
| AID566623 | Antifungal activity against Candida glabrata after 24 hrs by MTT assay | 2011 | European journal of medicinal chemistry, Jan, Volume: 46, Issue:1 | Synthesis and biological evaluation of novel 2,4-disubstituted-1,3-thiazoles as anti-Candida spp. agents. |
| AID319919 | Antifungal activity against Candida albicans PTCC 5027 after 24 to 48 hrs by agar dilution method | 2008 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 18, Issue:1 | 2-Hydroxyphenacyl azoles and related azolium derivatives as antifungal agents. |
| AID45503 | In vivo Evaluation of minimum inhibitory concentration against Candida albicans 60 | 1995 | Journal of medicinal chemistry, Sep-29, Volume: 38, Issue:20 | Synthesis and antifungal activity of new azole derivatives containing an N-acylmorpholine ring. |
| AID1379938 | Antifungal activity against Candida tropicalis clinical isolates assessed as inhibition of microbial growth incubated for 24 hrs by broth microdilution method | 2017 | European journal of medicinal chemistry, Nov-10, Volume: 140 | Synthesis, biological evaluation and quantitative structure-active relationships of 1,3-thiazolidin-4-one derivatives. A promising chemical scaffold endowed with high antifungal potency and low cytotoxicity. |
| AID743892 | Antifungal activity against Aspergillus fumigatus Af293 at 5 mg/mL after 48 hrs | 2013 | European journal of medicinal chemistry, May, Volume: 63 | Synthesis, antimicrobial, antiquorum-sensing, antitumor and cytotoxic activities of new series of fused [1,3,4]thiadiazoles. |
| AID532570 | Antifungal activity against wild-type Candida glabrata isolate 21231 by Etest method | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | A nonsense mutation in the ERG6 gene leads to reduced susceptibility to polyenes in a clinical isolate of Candida glabrata. |
| AID1063954 | Antifungal activity against Candida albicans ATCC 44859 after 24 hrs by broth microdilution method | 2014 | Bioorganic & medicinal chemistry, Jan-15, Volume: 22, Issue:2 | Salicylanilide diethyl phosphates: synthesis, antimicrobial activity and cytotoxicity. |
| AID547601 | Antifungal activity against Candida glabrata isolate Cg22R with CgPDR1 L280F mutant | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | Microarray and molecular analyses of the azole resistance mechanism in Candida glabrata oropharyngeal isolates. |
| AID561633 | Antimicrobial activity against Aspergillus fumigatus at 8 to 32 ug/ml | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Heteroresistance to fluconazole in Cryptococcus neoformans is intrinsic and associated with virulence. |
| AID285873 | Antimicrobial susceptibility of Pichia anomala from nosocomial fungemia patient assessed as percent susceptible isolates at 16 ug/ml by EUCAST method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Antifungal drug susceptibility profile of Pichia anomala isolates from patients presenting with nosocomial fungemia. |
| AID1820640 | Antifungal activity against Cryptococcus neoformans GIM 2.209 assessed as inhibition of fungal growth by NCCLS protocol based method | 2022 | European journal of medicinal chemistry, Jan-15, Volume: 228 | Design, synthesis, and biological activity evaluation of 2-(benzo[b]thiophen-2-yl)-4-phenyl-4,5-dihydrooxazole derivatives as broad-spectrum antifungal agents. |
| AID537671 | Antifungal activity against Saccharomyces cerevisiae RSKK 251 after 18 hrs by agar-well diffusion method | 2010 | European journal of medicinal chemistry, Nov, Volume: 45, Issue:11 | Cyclization of some carbothioamide derivatives containing antipyrine and triazole moieties and investigation of their antimicrobial activities. |
| AID1598043 | Antifungal activity against Cryptococcus neoformans after 24 hrs | 2019 | European journal of medicinal chemistry, May-15, Volume: 170 | Current advances of triazole alcohols derived from fluconazole: Design, in vitro and in silico studies. |
| AID1456576 | Antifungal activity against Candida albicans isolate Y0109 by micro-broth dilution method | 2017 | Bioorganic & medicinal chemistry letters, 05-15, Volume: 27, Issue:10 | Design, synthesis, and in vitro evaluation of novel antifungal triazoles. |
| AID545166 | Antimicrobial activity against Candida albicans isolate C after 48 hrs by microdilution method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Breakthrough Aspergillus fumigatus and Candida albicans double infection during caspofungin treatment: laboratory characteristics and implication for susceptibility testing. |
| AID1877304 | Antibiofilm activity against FLC-resistant Candida albicans CPCC400616 assessed as assessed as inhibition of biofilm formation measured at 3 hrs by XTT reduction assay | 2022 | European journal of medicinal chemistry, Jan-05, Volume: 227 | Broadening antifungal spectrum and improving metabolic stablity based on a scaffold strategy: Design, synthesis, and evaluation of novel 4-phenyl-4,5-dihydrooxazole derivatives as potent fungistatic and fungicidal reagents. |
| AID375814 | Antifungal activity against Fusarium oxysporum NCIM 1332 by agar plate assay | 2009 | Bioorganic & medicinal chemistry letters, Jul-01, Volume: 19, Issue:13 | Synthesis of novel 3-(1-(1-substituted piperidin-4-yl)-1H-1,2,3-triazol-4-yl)-1,2,4-oxadiazol-5(4H)-one as antifungal agents. |
| AID1154844 | Antifungal activity against fluconazole-sensitive Candida albicans SC5314 assessed as abnormal cell shape at 8 ug/ml after 8 hrs by TEM analysis | 2014 | ACS medicinal chemistry letters, May-08, Volume: 5, Issue:5 | Novel carboline derivatives as potent antifungal lead compounds: design, synthesis, and biological evaluation. |
| AID1254070 | Antibacterial activity against Streptococcus mutans 3065 after 24 hrs by two-fold serial dilution method | 2015 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 25, Issue:22 | Synthesis and biological evaluation of 1,3-diaryl pyrazole derivatives as potential antibacterial and anti-inflammatory agents. |
| AID434893 | Antifungal activity against Candida tropicalis isolate 5 in RPMI 1640 medium by broth dilution susceptibility test | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | In vitro study of Candida tropicalis isolates exhibiting paradoxical growth in the presence of high concentrations of caspofungin. |
| AID1759436 | Antifungal activity against Cryptococcus neoformans PFCC 93-589 after 7 days in presence of sorbitol by microdilution assay | 2021 | Bioorganic & medicinal chemistry letters, 06-01, Volume: 41 | Inhibitory effects and mechanism of antifungal action of the natural cyclic depsipeptide, aureobasidin A against Cryptococcus neoformans. |
| AID642932 | Antifungal activity against Candida tropicalis ATCC 750 at 160 ug/ml | 2011 | ACS medicinal chemistry letters, May-12, Volume: 2, Issue:5 | Natural Product Based 6-Hydroxy-2,3,4,6-tetrahydropyrrolo[1,2-a]pyrimidinium Scaffold as A New Antifungal Template. |
| AID584415 | Antifungal activity against 31 days cultured Candida glabrata isolated from HSCT recipient with acute or chronic GVHD mouth receiving antifungal therapy for 31 days after 28 days of prophylaxis by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Impact of antifungal prophylaxis on colonization and azole susceptibility of Candida species. |
| AID257544 | Antifungal activity against Candida albicans | 2005 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 15, Issue:23 | Synthesis and biological evaluation of novel (L)-alpha-amino acid methyl ester, heteroalkyl, and aryl substituted 1,4-naphthoquinone derivatives as antifungal and antibacterial agents. |
| AID581876 | Antifungal activity against Candida glabrata isolated from neutropenic subject 1491 with AML or MDS pharynx after 23 days prophylaxis by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Impact of antifungal prophylaxis on colonization and azole susceptibility of Candida species. |
| AID1176263 | Antifungal activity against Cryptococcus neoformans after 2 to 7 days by serial plate dilution method | 2015 | Bioorganic & medicinal chemistry letters, Jan-15, Volume: 25, Issue:2 | Ionic liquid catalyzed synthesis of 2-(indole-3-yl)-thiochroman-4-ones and their novel antifungal activities. |
| AID1822496 | Antifungal activity against Candida tropicalis 660 assessed as reduction in drug tolerance by measuring zone of inhibition at 25 ug incubated for 24 to 48 hrs by disk diffusion assay | 2022 | Journal of medicinal chemistry, 02-10, Volume: 65, Issue:3 | Fluconazole-COX Inhibitor Hybrids: A Dual-Acting Class of Antifungal Azoles. |
| AID1465981 | Antifungal activity against Candida tropicalis ATCC 1369 after 44 hrs by broth dilution assay | 2017 | Bioorganic & medicinal chemistry, 06-01, Volume: 25, Issue:11 | Investigation of aryl isonitrile compounds with potent, broad-spectrum antifungal activity. |
| AID1472625 | In vitro antifungal activity against Trichophyton verrucosum after 7 days by serial dilution method | 2018 | Journal of medicinal chemistry, 01-11, Volume: 61, Issue:1 | Novel Terminal Bipheny-Based Diapophytoene Desaturases (CrtN) Inhibitors as Anti-MRSA/VISR/LRSA Agents with Reduced hERG Activity. |
| AID582773 | Antifungal activity against Candida albicans isolate 177 assessed as 14alpha-methyl fecosterol content in total sterol composition at 0.5 times MIC by GC-MS analysis | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | Identification and characterization of four azole-resistant erg3 mutants of Candida albicans. |
| AID565554 | Antifungal activity against Rhizopus microsporus UTHSC 04-3294 by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Correlation of in vitro activity, serum levels, and in vivo efficacy of posaconazole against Rhizopus microsporus in a murine disseminated infection. |
| AID584375 | Ratio of CDR2 gene expression in Candida glabrata isolated from patient 497 receiving antifungal drug to CDR2 gene expression in Candida glabrata isolated from patient 497 by RT-PCR analysis | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Impact of antifungal prophylaxis on colonization and azole susceptibility of Candida species. |
| AID670393 | Antifungal activity against Candida albicans MTCC 3958 by well diffusion method | 2012 | Bioorganic & medicinal chemistry letters, Jul-15, Volume: 22, Issue:14 | Synthesis, biological evaluation of 5-carbomethoxymethyl-7-hydroxy-2-pentylchromone, 5-carboethoxymethyl-4',7-dihydroxyflavone and their analogues. |
| AID518431 | Antimicrobial activity against Cryptococcus gattii serotype B isolate NIH535 assessed as heteroresistant isolates at 4 ug/ml | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Heteroresistance of Cryptococcus gattii to fluconazole. |
| AID1783068 | Antifungal activity against fluconazole-sensitive Candida albicans 4108 assessed as inhibition of fungal growth | 2021 | European journal of medicinal chemistry, Oct-05, Volume: 221 | Lanosterol 14α-demethylase (CYP51)/histone deacetylase (HDAC) dual inhibitors for treatment of Candida tropicalis and Cryptococcus neoformans infections. |
| AID1728514 | Inhibition of CYP51 in Candida albicans ATCC SC5314 assessed as lanosterol level at 4 ug/ml incubated for 48 hrs by LC/MS analysis | 2021 | European journal of medicinal chemistry, Jan-15, Volume: 210 | Novel naphthylamide derivatives as dual-target antifungal inhibitors: Design, synthesis and biological evaluation. |
| AID1863780 | Antifungal activity against wild type Candida albicans SN152 assessed as inhibition of fungal growth by broth microdilution method | 2022 | European journal of medicinal chemistry, Oct-05, Volume: 240 | β-Nitrostyrene derivatives as broad range potential antifungal agents targeting fungal cell wall. |
| AID581860 | Antifungal activity against Candida glabrata isolated from neutropenic subjects with AML or MDS receiving fluconazole assessed as maximum MIC by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Impact of antifungal prophylaxis on colonization and azole susceptibility of Candida species. |
| AID1706896 | Thiol-reactivity using La antigen containing reactive cysteine C245 at 50 mM incubated for 1 hr by MS analysis based ALARM MSPS analysis | 2020 | Journal of medicinal chemistry, 12-10, Volume: 63, Issue:23 | Synthesis of Guaianolide Analogues with a Tunable α-Methylene-γ-lactam Electrophile and Correlating Bioactivity with Thiol Reactivity. |
| AID594997 | Antifungal activity against Trichophyton mentagrophytes after 48 hrs by Halo zone test | 2011 | Bioorganic & medicinal chemistry letters, May-15, Volume: 21, Issue:10 | Thermal solvent-free synthesis of novel pyrazolyl chalcones and pyrazolines as potential antimicrobial agents. |
| AID1334849 | Anti-fungal activity against Cryptococcus neoformans CGMCC 2.3161 by broth microdilution method | 2017 | Bioorganic & medicinal chemistry, 01-15, Volume: 25, Issue:2 | Discovery of biphenyl imidazole derivatives as potent antifungal agents: Design, synthesis, and structure-activity relationship studies. |
| AID1759472 | Cytotoxicity against human HEK293 cells assessed as cell viability at 2 times MIC incubated for 24 hrs by MTT assay | 2021 | Bioorganic & medicinal chemistry letters, 06-01, Volume: 41 | Inhibitory effects and mechanism of antifungal action of the natural cyclic depsipeptide, aureobasidin A against Cryptococcus neoformans. |
| AID510618 | Antifungal activity against Candida tropicalis by serial dilution method | 2010 | European journal of medicinal chemistry, Sep, Volume: 45, Issue:9 | Design, synthesis and antifungal activity of isosteric analogues of benzoheterocyclic N-myristoyltransferase inhibitors. |
| AID285875 | Antimicrobial susceptibility of Pichia anomala from nosocomial fungemia patient assessed as percent susceptible isolates by EUCAST method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Antifungal drug susceptibility profile of Pichia anomala isolates from patients presenting with nosocomial fungemia. |
| AID1689228 | Antibacterial activity against Lactobacillus gasseri HM-400 assessed as reduction in bacterial growth by CLSI based assay | 2020 | European journal of medicinal chemistry, Mar-01, Volume: 189 | Oxadiazolylthiazoles as novel and selective antifungal agents. |
| AID655584 | Antifungal activity against Candida tropicalis by microbroth dilution method | 2012 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 22, Issue:8 | New triazole derivatives as antifungal agents: synthesis via click reaction, in vitro evaluation and molecular docking studies. |
| AID80624 | Percent relaxation using isolated guinea pig trachea. | 1998 | Bioorganic & medicinal chemistry letters, Mar-03, Volume: 8, Issue:5 | New bronchodilators selected by molecular topology. |
| AID1079948 | Times to onset, minimal and maximal, observed in the indexed observations. [column 'DELAI' in source] | |||
| AID1157159 | Antifungal activity against Candida parapsilosis DSM 11224 after 48 hrs by CLSI broth microdilution method | 2014 | European journal of medicinal chemistry, Aug-18, Volume: 83 | Synthesis, biological evaluation and structure-activity correlation study of a series of imidazol-based compounds as Candida albicans inhibitors. |
| AID1634154 | Inhibition of CYP3A4 (unknown origin) | 2019 | Bioorganic & medicinal chemistry letters, 08-15, Volume: 29, Issue:16 | Strategies for the development of highly selective cytochrome P450 inhibitors: Several CYP targets in current research. |
| AID1312607 | Antifungal activity against naftifine-sensitive Trichophyton rubrum after 7 days by serial dilution method | 2016 | Journal of medicinal chemistry, 05-26, Volume: 59, Issue:10 | Discovery of Benzocycloalkane Derivatives Efficiently Blocking Bacterial Virulence for the Treatment of Methicillin-Resistant S. aureus (MRSA) Infections by Targeting Diapophytoene Desaturase (CrtN). |
| AID462226 | Antifungal activity against pharmacoresistant Candida albicans AIDS68 infected in Wistar rat estrogen-dependent fungal vaginitis model assessed as fungal burden at 10 ug administered intravaginally 1 hr after fungal infection measured on day 1 after infec | 2010 | Journal of medicinal chemistry, Mar-25, Volume: 53, Issue:6 | Identification of inhibitors of drug-resistant Candida albicans strains from a library of bicyclic peptidomimetic compounds. |
| AID1762147 | Solubility, log S of compound in 1-octanol at pH 7.4 | 2021 | Bioorganic & medicinal chemistry letters, 05-15, Volume: 40 | Synthesis and antifungal activity of new hybrids thiazolo[4,5-d]pyrimidines with (1H-1,2,4)triazole. |
| AID1918374 | Antifungal activity against Candida albicans infected in mouse assessed as disappearance of nuclear aggregation in the infection region at 20 mg/kg, ip administered on days 2,4,6,8,10,12 and measured on day 14 by hematoxyin-eosin staining based analysis | 2022 | Journal of medicinal chemistry, 11-10, Volume: 65, Issue:21 | Novel Aryl Alkamidazole Derivatives as Multifunctional Antifungal Inhibitors: Design, Synthesis, and Biological Evaluation. |
| AID249389 | In vitro concentration causing 90% inhibition of Candida albicans with percentage of resistant strains %R = 45.45 (MIC > 64 ug/mL) at a range of 0.125-0.5 ug/mL | 2005 | Journal of medicinal chemistry, Aug-11, Volume: 48, Issue:16 | Antifungal agents. 11. N-substituted derivatives of 1-[(aryl)(4-aryl-1H-pyrrol-3-yl)methyl]-1H-imidazole: synthesis, anti-Candida activity, and QSAR studies. |
| AID754920 | Antifungal activity against Candida glabrata 20/I assessed as growth inhibition after 24 to 48 hrs by microbroth dilution method | 2013 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 23, Issue:12 | Synthesis and antimycobacterial evaluation of N-substituted 5-chloropyrazine-2-carboxamides. |
| AID1595048 | Antifungal activity against Candida albicans assessed as reduction in fungal cell growth incubated for 48 hrs by broth microdilution method | 2019 | European journal of medicinal chemistry, May-15, Volume: 170 | Tetrazole hybrids and their antifungal activities. |
| AID623057 | Antifungal activity against Trichophyton mentagrophytes 445 after 120 hrs by microdilution method | 2011 | Bioorganic & medicinal chemistry letters, Oct-15, Volume: 21, Issue:20 | Synthesis and biological activity of desmethoxy analogues of coruscanone A. |
| AID1494180 | Antifungal activity against Candida glabrata ATCC 2001 measured after 48 hrs by CLSI M27-A3 protocol based method | 2018 | Bioorganic & medicinal chemistry, 02-01, Volume: 26, Issue:3 | Novel fluconazole derivatives with promising antifungal activity. |
| AID364277 | Antifungal activity against Candida parapsilosis at 20 umol/ml after 48 hrs | 2008 | European journal of medicinal chemistry, Sep, Volume: 43, Issue:9 | Design, synthesis and characterization of some bioactive conjugates of curcumin with glycine, glutamic acid, valine and demethylenated piperic acid and study of their antimicrobial and antiproliferative properties. |
| AID584598 | Antifungal activity against 6 days cultured Candida krusei isolated from neutropenic subject with AML or MDS stool receiving antifungal therapy for 19 days after 6 days of prophylaxis by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Impact of antifungal prophylaxis on colonization and azole susceptibility of Candida species. |
| AID519684 | Antimicrobial activity against Saccharomyces cerevisiae containing disruption in YGL072C gene by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Genomewide screening for genes associated with gliotoxin resistance and sensitivity in Saccharomyces cerevisiae. |
| AID510326 | Antifungal activity against Candida albicans ATCC 76615 after 24 hrs by micro-broth dilution method | 2010 | European journal of medicinal chemistry, Sep, Volume: 45, Issue:9 | Synthesis and biological activities of novel amine-derived bis-azoles as potential antibacterial and antifungal agents. |
| AID118075 | In vivo evaluation of % survival rate after peroral administration on 9th day at dose 20 mg/kg | 1995 | Journal of medicinal chemistry, Sep-29, Volume: 38, Issue:20 | Synthesis and antifungal activity of new azole derivatives containing an N-acylmorpholine ring. |
| AID1758028 | Inhibition of CYP51 in Candida albicans ATCC SC5314 assessed as ergosterol level at 0.5 ug/ml after 16 hrs by GC-MS analysis (Rvb = 98.3%) | 2021 | European journal of medicinal chemistry, Apr-15, Volume: 216 | Lead optimization generates selenium-containing miconazole CYP51 inhibitors with improved pharmacological profile for the treatment of fungal infections. |
| AID319920 | Antifungal activity against Saccharomyces cerevisiae PTCC 5177 after 24 to 48 hrs by agar dilution method | 2008 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 18, Issue:1 | 2-Hydroxyphenacyl azoles and related azolium derivatives as antifungal agents. |
| AID747349 | Antibacterial activity against Pseudomonas aeruginosa by NCCLS method | 2013 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 23, Issue:11 | Synthesis and biological evaluation of a class of quinolone triazoles as potential antimicrobial agents and their interactions with calf thymus DNA. |
| AID1428244 | Antifungal activity against Candida albicans measured after 18 hrs by agar dilution method | 2017 | European journal of medicinal chemistry, Jan-27, Volume: 126 | An insight on synthetic and medicinal aspects of pyrazolo[1,5-a]pyrimidine scaffold. |
| AID521981 | Antibacterial activity against Fluconazole resistant Candida albicans DSY3083 containing tac1delta/delta genotype containing CIp10 to restore URA3 function infected in BALB/c mouse assessed as effect on infection outcome score administered intraperitoneal | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Genetic dissection of azole resistance mechanisms in Candida albicans and their validation in a mouse model of disseminated infection. |
| AID274100 | Effect of compound on Candida albicans sensitivity to Fluconazole: Minimum inhibitory concentration required to inhibit the growth of 90% of isolates after 48h. | 2007 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 17, Issue:5 | Discovery of uracil-based histone deacetylase inhibitors able to reduce acquired antifungal resistance and trailing growth in Candida albicans. |
| AID279708 | Increase in drug binding to Candida albicans K1 biofilm cell walls, supernatant and matrix as compared to respective planktonic controls | 2007 | Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2 | Putative role of beta-1,3 glucans in Candida albicans biofilm resistance. |
| AID1413324 | Antifungal activity against Cryptococcus neoformans H99 | 2018 | MedChemComm, Jun-01, Volume: 9, Issue:6 | Antifungal amphiphilic kanamycins: new life for an old drug. |
| AID1890275 | Antifungal activity against Microsporum gypseum clinical isolate 2 assessed as reduction in fungal growth by broth dilution method | 2022 | Bioorganic & medicinal chemistry letters, 05-01, Volume: 63 | Novel 2-aryl-4-aryloxyquinoline-based fungistatics for Mucor circinelloides. Biological evaluation of activity, QSAR and docking study. |
| AID1904255 | Anti-cryptococcal activity against Cryptococcus neoformans H99 assessed as inhibition of fungal growth incubated for 72 hrs by microdilution method | 2022 | Journal of medicinal chemistry, 05-12, Volume: 65, Issue:9 | Discovery of Novel Sertraline Derivatives as Potent Anti- |
| AID1886117 | Antifungal activity against Cryptococcus neoformans H99 infected in Wax moth larvae assessed as survival rate at 10 mg/kg measured after 9 days by Kaplan-Meier method | |||
| AID1391389 | Antifungal activity against Candida albicans after 24 hrs by two fold serial dilution method | 2018 | Bioorganic & medicinal chemistry letters, 05-15, Volume: 28, Issue:9 | Novel purine benzimidazoles as antimicrobial agents by regulating ROS generation and targeting clinically resistant Staphylococcus aureus DNA groove. |
| AID1759427 | Antifungal activity against Cryptococcus neoformans PFCC 93-589 by broth microdilution assay | 2021 | Bioorganic & medicinal chemistry letters, 06-01, Volume: 41 | Inhibitory effects and mechanism of antifungal action of the natural cyclic depsipeptide, aureobasidin A against Cryptococcus neoformans. |
| AID545713 | Antifungal activity against Candida albicans after 24 hrs by serial dilution method | 2010 | European journal of medicinal chemistry, Dec, Volume: 45, Issue:12 | Novel conformationally restricted triazole derivatives with potent antifungal activity. |
| AID49800 | In vitro antifungal activity against Aspergillus fumigatus CF 1003 | 2000 | Bioorganic & medicinal chemistry letters, Jul-03, Volume: 10, Issue:13 | Synthesis and structure-activity relationships of novel fungal chitin synthase inhibitors. |
| AID1877302 | Inhibition of CYP51 in Candida albicans SC3514 assessed as decrease in ergosterol biosynthesis by measuring unknown sterol 5 level at 0.25 ug/ml incubated for 16 hrs by GC-MS analysis relative to total sterols | 2022 | European journal of medicinal chemistry, Jan-05, Volume: 227 | Broadening antifungal spectrum and improving metabolic stablity based on a scaffold strategy: Design, synthesis, and evaluation of novel 4-phenyl-4,5-dihydrooxazole derivatives as potent fungistatic and fungicidal reagents. |
| AID516305 | Antimicrobial activity against Cryptococcus gattii serotype B isolate NIH286 assessed as concentration required for heteroresistance | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Heteroresistance of Cryptococcus gattii to fluconazole. |
| AID567855 | Antidepressant activity in Albino rat assessed as immobility time at 20 mg/kg, ip by forced swimming test (Rvb = 112.4 +/- 2.88 sec) | 2011 | European journal of medicinal chemistry, Feb, Volume: 46, Issue:2 | Synthesis, antidepressant and antifungal evaluation of novel 2-chloro-8-methylquinoline amine derivatives. |
| AID1355719 | Antifungal activity against FLC resistant Candida albicans 0304103 at 1 ug/ml up to 24 hrs by checkerboard microdilution method | 2018 | Journal of medicinal chemistry, Jul-26, Volume: 61, Issue:14 | Discovery of Janus Kinase 2 (JAK2) and Histone Deacetylase (HDAC) Dual Inhibitors as a Novel Strategy for the Combinational Treatment of Leukemia and Invasive Fungal Infections. |
| AID608674 | Antifungal activity against Candida albicans at 1000 ug/ml after 72 hrs by agar diffusion method by agar diffusion method | 2011 | European journal of medicinal chemistry, Aug, Volume: 46, Issue:8 | Synthesis, characterization and antimicrobial studies of some new pyrazole incorporated imidazole derivatives. |
| AID1419547 | Selectivity index, ratio of EC50 for toxicity in human A549 cells to MIC50 for antifungal activity against ITC and FLC-susceptible Candida albicans ATCC MYA-2310 | 2017 | European journal of medicinal chemistry, Jun-16, Volume: 133 | Novel alkylated azoles as potent antifungals. |
| AID493511 | Antifungal activity against Candida albicans ATCC 44859 after 24 hrs by broth microdilution assay | 2010 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 20, Issue:15 | N-Benzylsalicylthioamides as novel compounds with promising antimycotic activity. |
| AID375816 | Antifungal activity against Aspergillus niger NCIM 1196 by agar plate assay | 2009 | Bioorganic & medicinal chemistry letters, Jul-01, Volume: 19, Issue:13 | Synthesis of novel 3-(1-(1-substituted piperidin-4-yl)-1H-1,2,3-triazol-4-yl)-1,2,4-oxadiazol-5(4H)-one as antifungal agents. |
| AID143891 | Inhibitory activity against human N-Myristoyltransferase (HsNmt) assessed as inhibitory concentration using substrate peptide and myristotyl-CoA; Not tested | 2002 | Bioorganic & medicinal chemistry letters, Feb-25, Volume: 12, Issue:4 | Design and synthesis of novel benzofurans as a new class of antifungal agents targeting fungal N-myristoyltransferase. Part 2. |
| AID1609925 | Antifungal activity against Candida albicans SC5314 assessed as reduction in fungal growth incubated for 24 hrs by serial dilution method | |||
| AID1347091 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for SJ-GBM2 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347154 | Primary screen GU AMC qHTS for Zika virus inhibitors | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49 | Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1508630 | Primary qHTS for small molecule stabilizers of the endoplasmic reticulum resident proteome: Secreted ER Calcium Modulated Protein (SERCaMP) assay | 2021 | Cell reports, 04-27, Volume: 35, Issue:4 | A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. |
| AID1347101 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for BT-12 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1296008 | Cytotoxic Profiling of Annotated Libraries Using Quantitative High-Throughput Screening | 2020 | SLAS discovery : advancing life sciences R & D, 01, Volume: 25, Issue:1 | Cytotoxic Profiling of Annotated and Diverse Chemical Libraries Using Quantitative High-Throughput Screening. |
| AID1745845 | Primary qHTS for Inhibitors of ATXN expression | |||
| AID1347107 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for Rh30 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347086 | qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lymphocytic Choriomeningitis Arenaviruses (LCMV): LCMV Primary Screen - GLuc reporter signal | 2020 | Antiviral research, 01, Volume: 173 | A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity. |
| AID1347108 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for Rh41 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347106 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for control Hh wild type fibroblast cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347089 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for TC32 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347083 | qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lassa (LASV) Arenavirus: Viability assay - alamar blue signal for LASV Primary Screen | 2020 | Antiviral research, 01, Volume: 173 | A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity. |
| AID1347102 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for Rh18 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347096 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for U-2 OS cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347097 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for Saos-2 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347098 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for SK-N-SH cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347095 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for NB-EBc1 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347100 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for LAN-5 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347105 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for MG 63 (6-TG R) cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347104 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for RD cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347093 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for SK-N-MC cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347090 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for DAOY cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347092 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for A673 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1346986 | P-glycoprotein substrates identified in KB-3-1 adenocarcinoma cell line, qHTS therapeutic library screen | 2019 | Molecular pharmacology, 11, Volume: 96, Issue:5 | A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. |
| AID1347103 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for OHS-50 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347094 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for BT-37 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347099 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for NB1643 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1346987 | P-glycoprotein substrates identified in KB-8-5-11 adenocarcinoma cell line, qHTS therapeutic library screen | 2019 | Molecular pharmacology, 11, Volume: 96, Issue:5 | A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. |
| AID1347082 | qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lassa (LASV) Arenavirus: LASV Primary Screen - GLuc reporter signal | 2020 | Antiviral research, 01, Volume: 173 | A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity. |
| AID1347407 | qHTS to identify inhibitors of the type 1 interferon - major histocompatibility complex class I in skeletal muscle: primary screen against the NCATS Pharmaceutical Collection | 2020 | ACS chemical biology, 07-17, Volume: 15, Issue:7 | High-Throughput Screening to Identify Inhibitors of the Type I Interferon-Major Histocompatibility Complex Class I Pathway in Skeletal Muscle. |
| AID1347425 | Rhodamine-PBP qHTS Assay for Modulators of WT P53-Induced Phosphatase 1 (WIP1) | 2019 | The Journal of biological chemistry, 11-15, Volume: 294, Issue:46 | Physiologically relevant orthogonal assays for the discovery of small-molecule modulators of WIP1 phosphatase in high-throughput screens. |
| AID651635 | Viability Counterscreen for Primary qHTS for Inhibitors of ATXN expression | |||
| AID1347424 | RapidFire Mass Spectrometry qHTS Assay for Modulators of WT P53-Induced Phosphatase 1 (WIP1) | 2019 | The Journal of biological chemistry, 11-15, Volume: 294, Issue:46 | Physiologically relevant orthogonal assays for the discovery of small-molecule modulators of WIP1 phosphatase in high-throughput screens. |
| AID504749 | qHTS profiling for inhibitors of Plasmodium falciparum proliferation | 2011 | Science (New York, N.Y.), Aug-05, Volume: 333, Issue:6043 | Chemical genomic profiling for antimalarial therapies, response signatures, and molecular targets. |
| AID588501 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
| AID588501 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5 | Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
| AID588501 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1 | High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
| AID588497 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
| AID588497 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5 | Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
| AID588497 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1 | High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
| AID588499 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
| AID588499 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5 | Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
| AID588499 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1 | High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
| AID1799166 | In Vitro HO Activity Assay from Article 10.1124/jpet.106.102699: \\Inhibition of the enzymatic activity of heme oxygenases by azole-based antifungal drugs.\\ | 2006 | The Journal of pharmacology and experimental therapeutics, Oct, Volume: 319, Issue:1 | Inhibition of the enzymatic activity of heme oxygenases by azole-based antifungal drugs. |
| AID1799528 | Inhibition Assay from Article 10.1016/j.chembiol.2007.10.011: \\Sterol 14alpha-demethylase as a potential target for antitrypanosomal therapy: enzyme inhibition and parasite cell growth.\\ | 2007 | Chemistry & biology, Nov, Volume: 14, Issue:11 | Sterol 14alpha-demethylase as a potential target for antitrypanosomal therapy: enzyme inhibition and parasite cell growth. |
| AID1799791 | Binding Assay from Article 10.1074/jbc.M110.164293: \\Structural and biochemical characterization of Mycobacterium tuberculosis CYP142: evidence for multiple cholesterol 27-hydroxylase activities in a human pathogen.\\ | 2010 | The Journal of biological chemistry, Dec-03, Volume: 285, Issue:49 | Structural and biochemical characterization of Mycobacterium tuberculosis CYP142: evidence for multiple cholesterol 27-hydroxylase activities in a human pathogen. |
| AID1798586 | Ligand Binding Assay from Article 10.1128/AAC.00311-07: \\Small-molecule scaffolds for CYP51 inhibitors identified by high-throughput screening and defined by X-ray crystallography.\\ | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Small-molecule scaffolds for CYP51 inhibitors identified by high-throughput screening and defined by X-ray crystallography. |
| AID1347411 | qHTS to identify inhibitors of the type 1 interferon - major histocompatibility complex class I in skeletal muscle: primary screen against the NCATS Mechanism Interrogation Plate v5.0 (MIPE) Libary | 2020 | ACS chemical biology, 07-17, Volume: 15, Issue:7 | High-Throughput Screening to Identify Inhibitors of the Type I Interferon-Major Histocompatibility Complex Class I Pathway in Skeletal Muscle. |
| AID540299 | A screen for compounds that inhibit the MenB enzyme of Mycobacterium tuberculosis | 2010 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 20, Issue:21 | Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis. |
| AID588519 | A screen for compounds that inhibit viral RNA polymerase binding and polymerization activities | 2011 | Antiviral research, Sep, Volume: 91, Issue:3 | High-throughput screening identification of poliovirus RNA-dependent RNA polymerase inhibitors. |
| AID1159607 | Screen for inhibitors of RMI FANCM (MM2) intereaction | 2016 | Journal of biomolecular screening, Jul, Volume: 21, Issue:6 | A High-Throughput Screening Strategy to Identify Protein-Protein Interaction Inhibitors That Block the Fanconi Anemia DNA Repair Pathway. |
| AID1159550 | Human Phosphogluconate dehydrogenase (6PGD) Inhibitor Screening | 2015 | Nature cell biology, Nov, Volume: 17, Issue:11 | 6-Phosphogluconate dehydrogenase links oxidative PPP, lipogenesis and tumour growth by inhibiting LKB1-AMPK signalling. |
| AID1154664 | Binding affinity to PDE-delta in human PancTuI cells assessed as inhibition of Ras-PDE-delta complex formation after 2 hrs by pull down assay | 2014 | Journal of medicinal chemistry, Jun-26, Volume: 57, Issue:12 | Structure guided design and kinetic analysis of highly potent benzimidazole inhibitors targeting the PDEδ prenyl binding site. |
| AID1612789 | Inhibition of KRAS-PDEdelta interaction in human A549 cells harboring KRAS G12S point mutant assessed as reduction in RAF phosphorylation at 10 uM by Western blot analysis | 2019 | European journal of medicinal chemistry, Feb-01, Volume: 163 | Fragment-based drug discovery of triazole inhibitors to block PDEδ-RAS protein-protein interaction. |
| AID1658929 | Binding affinity to PDEdelta (unknown origin) | 2020 | Journal of medicinal chemistry, 07-23, Volume: 63, Issue:14 | Discovery of Novel PDEδ Degraders for the Treatment of KRAS Mutant Colorectal Cancer. |
| AID1475930 | Aqueous solubility of the compound at 5 mg/ml measured after 24 hrs by HPLC method | 2017 | Journal of medicinal chemistry, 11-22, Volume: 60, Issue:22 | Structural Biology-Inspired Discovery of Novel KRAS-PDEδ Inhibitors. |
| AID1475929 | Inhibition of Atrovastatin-PEG3-FITC binding to PDEdelta (unknown origin) incubated for 60 mins by fluorescence anisotropy assay | 2017 | Journal of medicinal chemistry, 11-22, Volume: 60, Issue:22 | Structural Biology-Inspired Discovery of Novel KRAS-PDEδ Inhibitors. |
| AID1612792 | Binding affinity to His6-tagged PDEdelta (unknown origin) by isothermal titration calorimetry | 2019 | European journal of medicinal chemistry, Feb-01, Volume: 163 | Fragment-based drug discovery of triazole inhibitors to block PDEδ-RAS protein-protein interaction. |
| AID1612790 | Inhibition of KRAS-PDEdelta interaction in human A549 cells harboring KRAS G12S point mutant assessed as reduction in S6K phosphorylation at 10 uM by Western blot analysis | 2019 | European journal of medicinal chemistry, Feb-01, Volume: 163 | Fragment-based drug discovery of triazole inhibitors to block PDEδ-RAS protein-protein interaction. |
| AID1154661 | Binding affinity to PDE-delta (unknown origin) by time-resolved fluorescence anisotropic analysis | 2014 | Journal of medicinal chemistry, Jun-26, Volume: 57, Issue:12 | Structure guided design and kinetic analysis of highly potent benzimidazole inhibitors targeting the PDEδ prenyl binding site. |
| AID1612793 | Antiproliferative activity against human A549 cells harboring KRAS G12S point mutant after 72 hrs by SRB assay | 2019 | European journal of medicinal chemistry, Feb-01, Volume: 163 | Fragment-based drug discovery of triazole inhibitors to block PDEδ-RAS protein-protein interaction. |
| AID1154663 | Binding affinity to PDE-delta in MDCK cell lysate after 2 hrs by pull down assay | 2014 | Journal of medicinal chemistry, Jun-26, Volume: 57, Issue:12 | Structure guided design and kinetic analysis of highly potent benzimidazole inhibitors targeting the PDEδ prenyl binding site. |
| AID1154665 | Binding affinity to PDE-delta in human PancTuI cells assessed as inhibition of Ras-PDE-delta complex formation at 500 nM after 2 hrs by pull down assay | 2014 | Journal of medicinal chemistry, Jun-26, Volume: 57, Issue:12 | Structure guided design and kinetic analysis of highly potent benzimidazole inhibitors targeting the PDEδ prenyl binding site. |
| AID1612787 | Inhibition of N-terminal His6-tagged PDEdelta (unknown origin) expressed in Escherichia coli BL21(DE3)-condon plus-RIL cells after 4 hrs by fluorescence polarization assay | 2019 | European journal of medicinal chemistry, Feb-01, Volume: 163 | Fragment-based drug discovery of triazole inhibitors to block PDEδ-RAS protein-protein interaction. |
| AID1612788 | Inhibition of KRAS-PDEdelta interaction in human A549 cells harboring KRAS G12S point mutant assessed as reduction in ERK phosphorylation at 10 uM by Western blot analysis | 2019 | European journal of medicinal chemistry, Feb-01, Volume: 163 | Fragment-based drug discovery of triazole inhibitors to block PDEδ-RAS protein-protein interaction. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 203 (2.32) | 18.7374 |
| 1990's | 1969 (22.46) | 18.2507 |
| 2000's | 2564 (29.24) | 29.6817 |
| 2010's | 2979 (33.98) | 24.3611 |
| 2020's | 1053 (12.01) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be very strong demand-to-supply ratio for research on this compound.
| This Compound (97.44) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 721 (7.72%) | 5.53% |
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 887 (9.49%) | 6.00% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 2,006 (21.47%) | 4.05% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 63 (0.67%) | 0.25% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 5,666 (60.64%) | 84.16% |
| Other | 13 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effects of Urocortins on Forearm Arterial Blood Flow in Healthy Volunteers [NCT01096706] | 10 participants (Actual) | Interventional | 2011-07-31 | Completed | |||
| Safety and Pharmacokinetics of Fluconazole Prophylaxis in Children Supported With Extracorporeal Membrane Oxygenation [NCT01169402] | Phase 1 | 21 participants (Actual) | Interventional | 2010-07-31 | Completed | ||
| AN OPEN-LABEL, RANDOMIZED, SINGLE DOSE, CROSSOVER PIVOTAL BIOEQUIVALENCE STUDY OF FLUCONAZOLE CAPSULE 50 MG IN HEALTHY ADULT SUBJECTS [NCT03821480] | Phase 1 | 28 participants (Actual) | Interventional | 2019-01-28 | Completed | ||
| An Open-label Study in HIV+ Patients to Determine the Effects of Nevirapine (VIRAMUNE®) on the Steady State Pharmacokinetics of Fluconazole (DIFLUCAN®) [NCT02181946] | Phase 4 | 24 participants (Actual) | Interventional | 2001-05-31 | Completed | ||
| Efficacy of Prophylactic Fluconazole Therapy in Preterm and Very Low Birth Weight Neonates in Preventing Invasive Fungal Infection. [NCT05848492] | Phase 3 | 110 participants (Actual) | Interventional | 2021-05-01 | Completed | ||
| Role of Epoxy-eicosatrienoic Acids in Post-occlusive Hyperemia and Thermal Hyperemia [NCT01290198] | 20 participants (Actual) | Interventional | 2011-02-28 | Completed | |||
| Phase 3, Randomized, Double-Blind Study to Evaluate Efficacy and Safety of Oteseconazole (VT-1161) Oral Capsules vs Fluconazole and Placebo in Treatment of Acute Vulvovaginal Candidiasis in Subjects With Recurrent Vulvovaginal Candidiasis [NCT03840616] | Phase 3 | 219 participants (Actual) | Interventional | 2019-03-13 | Completed | ||
| AN OPEN-LABEL, RANDOMIZED, SINGLE-DOSE, 2-WAY CROSSOVER BIOEQUIVALENCE STUDY COMPARING FLUCONAZOLE 150 MG CAPSULE (MANUFACTURED AT PFIZER DALIAN, CHINA) WITH FLUCONAZOLE 150 MG CAPSULE (MANUFACTURED AT PFIZER FAREVA, AMBOISE, FRANCE) UNDER FASTED AND FED [NCT03621072] | Phase 1 | 36 participants (Actual) | Interventional | 2019-06-03 | Completed | ||
| A Randomized, Prospective, Double-Blind Study Comparing Fluconazole With Placebo for Primary and Secondary Prophylaxis of Mucosal Candidiasis in HIV-Infected Women [NCT00000744] | 400 participants | Interventional | Completed | ||||
| Randomized Placebo-controlled Study on the Effects of Antibiotic-induced Gut MicrobiomE Disruption on the Innate Immune Response Following Cardiac Surgery [NCT03939273] | 80 participants (Anticipated) | Interventional | 2022-03-31 | Not yet recruiting | |||
| A Multicenter, Randomized, Controlled, Double-Blind, Double-Dummy, Two-Arm Study of Posaconazole vs Fluconazole in the Treatment of Coccidioidomycosis [NCT00423267] | Phase 3 | 16 participants (Actual) | Interventional | 2007-05-31 | Completed | ||
| A Randomized, Double-blind, Placebo-controlled Clinical Trial of Fluconazole as Early Empiric Treatment of Coccidioidomycosis Pneumonia (Valley Fever) in Adults Presenting With Community Acquired Pneumonia (CAP) in Endemic Areas (FLEET-Valley Fever) [NCT02663674] | Phase 4 | 72 participants (Actual) | Interventional | 2015-12-29 | Terminated(stopped due to Study terminated due to lack of feasibility of study design.) | ||
| Evaluation of a Public Health Strategy to Improve Survival of HIV Infected Patients [NCT02334670] | 2,612 participants (Anticipated) | Observational | 2015-08-14 | Active, not recruiting | |||
| Safety of Fluconazole Treatment of Premature and Full-term Newborn Infants - A Study on Interactions by Nonsteroidal Anti Inflammatory Drugs (NSAIDs) With Fluconazole in Respect of Pharmacodynamic Endpoints With Urinary Excretion of Vasoactive Endobiotics [NCT02079298] | Phase 4 | 80 participants (Actual) | Interventional | 2014-04-30 | Completed | ||
| A Phase I, Open-label, Single-center Study to Assess the Effect of the CYP3A4 Inhibitor Itraconazole and the CYP2C19 Inhibitor Fluconazole on the Pharmacokinetics of a 25 mg Single Oral Dose of Selumetinib (AZD6244; ARRY-142866) ( Hyd-Sulfate) in Healthy [NCT02093728] | Phase 1 | 26 participants (Actual) | Interventional | 2014-04-30 | Completed | ||
| A Phase 2, Multicenter, Randomized, Double-Blind, Double-Dummy, Active-Controlled, Dose-Finding Study to Compare the Safety and Efficacy of Oral Ibrexafungerp (SCY-078) vs. Oral Fluconazole in Subjects With Acute Vulvovaginal Candidiasis [NCT03253094] | Phase 2 | 186 participants (Actual) | Interventional | 2017-08-01 | Completed | ||
| Effect of Fluconazole on the Pharmacokinetics of a Single Oral Dose of BI 425809 in Healthy Male Subjects (an Open-label, Two-period Fixed-sequence Design Study) [NCT05076409] | Phase 1 | 15 participants (Actual) | Interventional | 2021-10-19 | Completed | ||
| A PHASE 1, OPEN-LABEL, RANDOMIZED, FIXED-SEQUENCE, PARALLEL-COHORT STUDY TO ESTIMATE THE EFFECT OF FLUVOXAMINE OR FLUCONAZOLE, ON THE PHARMACOKINETICS, SAFETY AND TOLERABILITY OF A SINGLE DOSE OF PF-04965842 IN HEALTHY SUBJECTS [NCT03634345] | Phase 1 | 24 participants (Actual) | Interventional | 2018-09-12 | Completed | ||
| A Phase 2, Multicenter, Randomized, Active-controlled Study of the Safety and Tolerability of Two Formulations of CD101 Compared to Fluconazole for the Treatment of Moderate to Severe Episodes of Acute Vulvovaginal Candidiasis [NCT02733432] | Phase 2 | 126 participants (Actual) | Interventional | 2016-06-08 | Completed | ||
| Pilot Study of Paroxetine and Fluconazole for the Treatment of HIV Associated Neurocognitive Disorder (HAND) [NCT01354314] | Phase 1/Phase 2 | 45 participants (Actual) | Interventional | 2010-11-30 | Completed | ||
| A Phase 1, Open-Label, Fixed-Sequence, Drug-Drug Interaction Study to Evaluate the Effect of Multiple Doses of Fluconazole, a CYP3A4 and CYP2C9 Inhibitor, on the Pharmacokinetics of CTP-543 in Healthy Subjects [NCT05478772] | Phase 1 | 18 participants (Actual) | Interventional | 2022-07-11 | Completed | ||
| A Phase III Open-Label Trial of Caspofungin vs. Azole Prophylaxis for Patients at High-Risk for Invasive Fungal Infections (IFI) Following Allogeneic Hematopoietic Cell Transplantation (HCT) [NCT01503515] | Phase 3 | 292 participants (Actual) | Interventional | 2013-03-21 | Completed | ||
| Comparative Study of Systemic Antifungal Drugs Used in Treatment of Onychomycosis [NCT03171584] | Phase 3 | 60 participants (Anticipated) | Interventional | 2017-07-01 | Not yet recruiting | ||
| Pharmacokinetic Effect of Fluconazole on SHR2554 in Healthy Subjects in Single-center, Open-label, Single-dose, Auto-controlled Pharmacokinetics [NCT05661591] | Phase 1 | 18 participants (Actual) | Interventional | 2023-02-28 | Completed | ||
| A Multi-Center Randomized Study to Evaluate the Safety, Tolerability, and Efficacy of Oral Encochleated Amphotericin B (CAMB/MAT2203) Compared With Oral Fluconazole in the Treatment of Moderate to Severe Vulvovaginal Candidiasis (VVC) [NCT02971007] | Phase 2 | 137 participants (Actual) | Interventional | 2016-11-30 | Completed | ||
| A Non-Randomized, Open-Label, Two-Part, Drug-Drug Interaction Study to Evaluate the Effects of Fluconazole and Quinidine on the Pharmacokinetics and Safety of EDP-305 in Healthy Volunteers [NCT03610945] | Phase 1 | 48 participants (Actual) | Interventional | 2018-07-19 | Completed | ||
| Risk of QT-prolongation and Torsade de Pointes in Patients Treated With Acute Medication in a University Hospital [NCT02068170] | 178 participants (Actual) | Observational | 2014-02-28 | Completed | |||
| Is the Naturally Occurring Prebiotic Lactoferrin an Acceptable Alternative to Antibiotic/Antifungal Tablets for Women With Bacterial Vaginosis or Thrush? [NCT05434104] | 114 participants (Anticipated) | Interventional | 2022-10-31 | Not yet recruiting | |||
| A Phase 3, Multicenter, Randomized, Double-Blind Study of the Efficacy and Safety of Rezafungin for Injection Versus the Standard Antimicrobial Regimen to Prevent Invasive Fungal Diseases in Adults Undergoing Allogeneic Blood and Marrow Transplantation (T [NCT04368559] | Phase 3 | 462 participants (Anticipated) | Interventional | 2020-05-11 | Recruiting | ||
| A Single Centre, Open-label Study, in Healthy Adult Volunteers, to Determine the Effects of Single-dose and Steady-state TPV/RTV 500/200 mg on the Steady-state Pharmacokinetics of Fluconazole 100 mg qd (200 mg Loading Dose) [NCT02195466] | Phase 1 | 20 participants (Actual) | Interventional | 2003-06-30 | Completed | ||
| An Open Label Phase IIa Clinical Study to Evaluate the Safety and Pharmacokinetics of Oral F901318 (Combined With Fluconazole and Posaconazole) in AML [NCT03036046] | Phase 1/Phase 2 | 0 participants (Actual) | Interventional | 2017-03-31 | Withdrawn(stopped due to Study no longer required) | ||
| A Phase 2, Multicenter, Randomized, Double-blind Study of the Safety, Tolerability, and Efficacy of Intravenous CD101 vs Intravenous Caspofungin Followed by Oral Fluconazole Step-down in the Treatment of Subjects With Candidemia and/or Invasive Candidiasi [NCT02734862] | Phase 2 | 207 participants (Actual) | Interventional | 2016-07-26 | Completed | ||
| A Randomized, Open-Label, Parallel Group, Drug-drug Interaction Study to Evaluate the Effect of Fluconazole and Itraconazole on the Pharmacokinetics of Erdafitinib in Healthy Adult Subjects [NCT03135106] | Phase 1 | 54 participants (Actual) | Interventional | 2017-04-14 | Completed | ||
| Drug-Drug Interaction Study of Multiple Doses of Pacritinib and CYP450 and, Transporter Substrates, and CYP450 3A4 Inducers and Inhibitors [NCT05657613] | Phase 1 | 60 participants (Actual) | Interventional | 2023-01-03 | Active, not recruiting | ||
| Drugs in Breast Milk [NCT05543122] | 304 participants (Anticipated) | Observational | 2022-03-09 | Recruiting | |||
| Safety and Tolerability of LY3154207 in Combination With a CYP3A4 Inhibitor and Assessment of Pharmacokinetics of LY3154207 After Administration of Capsule and Tablet Formulations in Healthy Subjects [NCT03942029] | Phase 1 | 36 participants (Actual) | Interventional | 2019-06-21 | Completed | ||
| Outcome of SD-OCT Guided Oral Anti-fungal Treatment of Fungal Chorioretinitis [NCT04947592] | 10 participants (Anticipated) | Observational | 2020-01-15 | Recruiting | |||
| An Open-label, Randomized, Two-treatment, Two-period, Two-sequence, Cross-over, Mono-center Bioequivalence Study to Compare Single Doses of Fluconazole 150 mg Capsule (Test Product) With Diflucan™ Capsule 150 mg (Reference) in Healthy Volunteers [NCT03929861] | Phase 1 | 26 participants (Actual) | Interventional | 2012-07-31 | Completed | ||
| A Randomized Open-Label Trial of Caspofungin Versus Fluconazole to Prevent Invasive Fungal Infections in Children Undergoing Chemotherapy for Acute Myeloid Leukemia (AML) [NCT01307579] | Phase 3 | 517 participants (Actual) | Interventional | 2011-04-04 | Completed | ||
| Randomized, Open Label, Non-inferiority Study of Micafungin Versus Standard Care for the Prevention of Invasive Fungal Disease in High Risk Liver Transplant Recipients [NCT01058174] | Phase 3 | 350 participants (Actual) | Interventional | 2009-12-15 | Completed | ||
| A Study of the Effect of Concomitant Administration of Ketoconazole or Fluconazole on the Pharmacokinetics of BMS-708163 in Healthy Subjects [NCT00860275] | Phase 1 | 30 participants (Actual) | Interventional | 2009-04-30 | Completed | ||
| Special Investigation Of Fluconazole For Pediatric Subjects [NCT01680458] | 30 participants (Actual) | Observational | 2012-11-30 | Completed | |||
| Comparative,Randomized,Single-dose,2-way Crossover Bioavailability Study of 40mgm/ml 35 ml Suspension and Pfizer (Diflucan®) 40 mg/ml 35 ml Fluconazole Suspension of Participants Under Fed Condition [NCT04502277] | Early Phase 1 | 200 participants (Anticipated) | Interventional | 2020-09-01 | Not yet recruiting | ||
| Safety and Clinical and Microbiological Efficacy of the Combination of Fluconazole and Secnidazole for the Treatment of Symptomatic Vaginal Discharge. Bogotá D. C. Colombia. [NCT02111629] | Phase 3 | 118 participants (Actual) | Interventional | 2012-05-31 | Completed | ||
| A Randomized Double-blind Trial of Fluconazole Versus Voriconazole for the Prevention of Invasive Fungal Infections in Allogeneic Blood and Marrow Transplant Patients (BMT CTN #0101) [NCT00075803] | Phase 3 | 600 participants (Actual) | Interventional | 2003-11-30 | Completed | ||
| A Phase 1 Study to Evaluate the Potential Drug Interactions Between ALXN2080 and Itraconazole, Fluconazole, and Carbamazepine in Healthy Adult Participants [NCT06173596] | Phase 1 | 60 participants (Anticipated) | Interventional | 2023-12-21 | Not yet recruiting | ||
| Rôle Des Acides Epoxy-eicosatriénoïques et du Monoxyde d'Azote Dans l'hyperhémie Post-occlusive cutanée Digitale et la réponse cutanée au Froid Dans le phénomène de Raynaud Primaire [NCT02183779] | 60 participants (Anticipated) | Interventional | 2014-06-30 | Recruiting | |||
| A Case Series of Investigator-Identified Fluconazole Failures: Outcome Characterization of Patients Who Fail to Respond to Fluconazole Treatment of Severe Infections Caused by Candida Albicans [NCT00721487] | 28 participants (Actual) | Observational | 2008-07-31 | Completed | |||
| A Phase 3, Multicenter, Prospective, Randomized, Double-blind Study of Two Treatment Regimens for Candidemia and/or Invasive Candidiasis: Intravenous Echinocandin Followed by Oral Ibrexafungerp Versus Intravenous Echinocandin Followed by Oral Fluconazole [NCT05178862] | Phase 3 | 220 participants (Anticipated) | Interventional | 2022-08-03 | Suspended(stopped due to During a review of manufacturing equipment and cleaning activities at a supplier that manufactured study drug for this study, SCYNEXIS was made aware of potential cross-contamination risk with a non-antibacterial beta-lactam drug substance.) | ||
| A Double-Blind, Placebo-Controlled Study of the Efficacy of Fluconazole as a Treatment for Autism Spectrum Disorder [NCT00936182] | 50 participants (Anticipated) | Interventional | 2009-07-31 | Recruiting | |||
| An Open-label Study to Evaluate the Safety, Tolerability and Pharmacokinetics of Cytochrome P450 Probe Drugs in Healthy Adult Subjects [NCT00964106] | Phase 1 | 87 participants (Actual) | Interventional | 2009-08-26 | Completed | ||
| An Open-Label, Multicenter, Two-Part, Phase 1 Study to Characterize the Effects of a Moderate CYP3A Inhibitor on the Pharmacokinetics of Tazemetostat (EPZ-6438) (Part A), the Effects of Tazemetostat on the Pharmacokinetics of CYP2C8 and CYP2C19 Substrates [NCT03028103] | Phase 1 | 32 participants (Actual) | Interventional | 2017-03-27 | Completed | ||
| Phase IV Open Label Non Comparative Trial Of IV Anidulafungin Followed By Oral Azole Therapy For The Treatment Of Candidemia And Invasive Candidiasis [NCT00496197] | Phase 4 | 282 participants (Actual) | Interventional | 2007-07-31 | Completed | ||
| A Single-center, Open-label, Fixed-sequence Study to Evaluate the Effects of Fluconazole on the Pharmacokinetics and Safety of Famitinib in Healthy Subjects [NCT05147727] | Phase 1 | 22 participants (Actual) | Interventional | 2022-03-14 | Completed | ||
| An Open-Label, Randomized, Two-Way Crossover Study To Evaluate The Effect Of Fluconazole, A Moderate CYP3A4 Inhibitor, On The Single-Dose Pharmacokinetics Of Fesoterodine In Healthy Subjects. [NCT00911235] | Phase 1 | 28 participants (Actual) | Interventional | 2009-05-31 | Completed | ||
| A Multicenter, Randomized, Evaluator Blinded, Active-Controlled Study to Evaluate the Safety and Efficacy of Oral Ibrexafungerp (SCY-078) vs. Oral Fluconazole in Subjects With Vulvovaginal Candidiasis [NCT02679456] | Phase 2 | 96 participants (Actual) | Interventional | 2015-11-30 | Completed | ||
| A Randomized Controlled Trial: the Effect of a Medical Grade Honey Formulation (L-Mesitran) on Clinical Symptoms of Recurrent Vulvovaginal Candidiasis [NCT05367089] | Phase 3 | 252 participants (Anticipated) | Interventional | 2022-08-22 | Recruiting | ||
| An Open Label, Multicenter Trial Of Diflucan (Fluconazole) For 6 Weeks Given Once Daily To Pediatric Patients With Tinea Capitis [NCT00645242] | Phase 3 | 185 participants (Anticipated) | Interventional | 2002-11-30 | Completed | ||
| [NCT00935363] | Phase 1 | 0 participants (Actual) | Interventional | 2010-02-28 | Withdrawn | ||
| Evaluation of the CYP2C9 Activity With Dried Blood Spots on Filter Paper Obtained With a Simple Finger Prick [NCT01026714] | Phase 1/Phase 2 | 10 participants (Anticipated) | Interventional | 2009-11-30 | Completed | ||
| Fluconazole Versus Micafungin in Neonates With Suspected or Culture-proven Candidiasis: a Randomized Pharmacokinetic and Safety Study (TINN Project - Treat Infections iN Neonates) [NCT02145832] | Phase 2/Phase 3 | 100 participants (Anticipated) | Interventional | 2014-06-30 | Not yet recruiting | ||
| An Open-Label, Randomized, Single-Dose, Two-Sequence, Two-Treatment, Four-Period, Crossover Study to Evaluate the Effects of Fluconazole on the Pharmacokinetics (PK) of Sativex® in Healthy Subjects With Cannabis Experience. [NCT02325011] | Phase 1 | 14 participants (Actual) | Interventional | 2014-11-30 | Completed | ||
| Open-Label, Non-Comparative, Study Of Intravenous Anidulafungin, Followed Optionally By Oral Voriconazole Or Fluconazole Therapy, For Treatment Of Documented Candidemia/Invasive Candidiasis In Intensive Care Unit Patient Populations [NCT00689338] | Phase 3 | 216 participants (Actual) | Interventional | 2008-07-31 | Completed | ||
| Comparison of Efficacy of Single Oral Dose Fluconazole and Itraconazole in Patients With Pityriasis Versicolor [NCT05862714] | Phase 1 | 164 participants (Actual) | Interventional | 2022-03-01 | Completed | ||
| A Phase 3, Randomized, Double-Blind, Comparative Trial of Micafungin Versus Fluconazole for the Treatment of Esophageal Candidiasis [NCT00666185] | Phase 3 | 523 participants (Actual) | Interventional | 2003-08-31 | Completed | ||
| Implementation and Evaluation of a Screening Strategy to Reduce Morbidity and Mortality Due to Cryptoccocal Meningo-encephalitis in ART Naive AIDS Patients With <100 CD4 Count at the Day Hospital of the Yaounde Central Hospital, Cameroon [NCT02624453] | 186 participants (Actual) | Interventional | 2015-07-31 | Active, not recruiting | |||
| A Randomized, Open Label Parallel Controlled, Multicenter Study to Evaluate Safety and Efficacy of Posaconazole Oral Suspension Vs. Fluconazole (Capsule) in High-risk Leukopenic Patients for Prevention of Invasive Fungal Infection [NCT00811928] | Phase 3 | 252 participants (Actual) | Interventional | 2008-11-30 | Completed | ||
| Evaluation of CrAg Screening With Enhanced Antifungal Therapy for Asymptomatic CrAg+ Persons [NCT03945448] | Phase 2/Phase 3 | 356 participants (Anticipated) | Interventional | 2019-06-20 | Recruiting | ||
| Diabetes Mellitus and Vulvovaginal Candidiasis: Prevalence of Infection and Its Rationale Management [NCT00353561] | Phase 3 | 100 participants (Actual) | Interventional | 2004-06-30 | Completed | ||
| AN INTERVENTIONAL EFFICACY AND SAFETY PHASE 3 DOUBLE-BLIND, 2-ARM STUDY TO INVESTIGATE IV FOLLOWED BY ORAL FOSMANOGEPIX (PF-07842805) COMPARED WITH IV CASPOFUNGIN FOLLOWED BY ORAL FLUCONAZOLE IN ADULT PARTICIPANTS WITH CANDIDEMIA AND/OR INVASIVE CANDIDIAS [NCT05421858] | Phase 3 | 450 participants (Anticipated) | Interventional | 2024-07-15 | Not yet recruiting | ||
| A Drug-Drug Interaction Study of Zanubrutinib With Moderate and Strong CYP3A Inhibitors in Patients With B-Cell Malignancies [NCT04551963] | Phase 1 | 26 participants (Actual) | Interventional | 2020-11-15 | Completed | ||
| Generation of Biological Samples Positive to Fluconazole for Anti-Doping Control [NCT04201054] | Phase 1 | 2 participants (Actual) | Interventional | 2019-03-25 | Completed | ||
| A Phase 3, Multicenter, Randomized, Double-blind Study of the Efficacy and Safety of Rezafungin for Injection vs. Intravenous Caspofungin Followed by Oral Fluconazole Step Down in the Treatment of Subjects With Candidemia and/or Invasive Candidiasis [NCT03667690] | Phase 3 | 199 participants (Actual) | Interventional | 2018-10-07 | Completed | ||
| A 3-Part, Open-Label Study to Assess Pharmacokinetic Drug-Drug Interaction Between Avatrombopag When Co-Administered With Fluconazole (Moderate Inhibitor of CYP2C9 and CYP3A), Itraconazole (Strong CYP3A Inhibitor), or Rifampin (Strong CYP3A and Moderate C [NCT02809768] | Phase 1 | 48 participants (Actual) | Interventional | 2016-04-30 | Completed | ||
| An Open Label Study in Healthy Volunteers to Evaluate the Potential for Drug/Drug Interactions Between F901318 and Fluconazole [NCT02730442] | Phase 1 | 20 participants (Actual) | Interventional | 2016-02-29 | Completed | ||
| Relative Bioavailability of 10 mcg Olodaterol (Solution for Inhalation Administered With the Respimat) at Steady State Alone or in Combination With Multiple Doses of 400 mg q.d. Fluconazole (Hard Capsule) in Healthy Male and Female Volunteers (an Open Lab [NCT01153724] | Phase 1 | 35 participants (Actual) | Interventional | 2010-05-31 | Completed | ||
| A Randomized Controlled Trial to Compare the Efficacy of a Medical Grade Honey Formulation (L-Mesitran®) and Fluconazol (Diflucan®) for the Treatment of Recurrent Vulvovaginal Candidiasis [NCT04626258] | Phase 4 | 252 participants (Anticipated) | Interventional | 2021-03-01 | Not yet recruiting | ||
| A Phase 1 Two-Part Study to Evaluate the Potential Drug Interactions Between ALXN2050 and Fluconazole, and Between ALXN2050 and Rifampin in Healthy Adult Participants [NCT04933682] | Phase 1 | 16 participants (Actual) | Interventional | 2021-06-23 | Completed | ||
| Clinical Effectiveness and Safety of Amphotericin B With Flucytosine-Fluconazole Therapy for Cryptococcal Meningitis in Patients With HIV Infection [NCT04532463] | 30 participants (Actual) | Observational | 2020-10-01 | Completed | |||
| Fluconazole Prophylaxis for the Prevention of Candidiasis in Infants < 750 Grams Birth [NCT00734539] | Phase 3 | 362 participants (Actual) | Interventional | 2008-11-30 | Completed | ||
| A PROSPECTIVE, OPEN-LABEL STUDY TO ASSESS THE PHARMACOKINETICS, SAFETY & EFFICACY OF ANIDULAFUNGIN WHEN USED TO TREAT CHILDREN WITH INVASIVE CANDIDIASIS, INCLUDING CANDIDEMIA [NCT00761267] | Phase 3 | 70 participants (Actual) | Interventional | 2009-02-28 | Completed | ||
| Randomized Control Trial of Early vs Delayed ART in the Treatment of Cryptococcal Meningitis. [NCT00830856] | 54 participants (Actual) | Interventional | 2006-10-31 | Completed | |||
| Randomized Comparative Study of Fluconazole Versus Clotrimazole Troches in the Prevention of Serious Fungal Infection in Patients With AIDS or Advanced AIDS-Related Complex. (A Nested Study of ACTG 081) [NCT00000676] | Phase 3 | 500 participants | Interventional | Completed | |||
| Multi-center Comparison of Fluconazole (UK-49,858) and Amphotericin B as Treatment for Acute Cryptococcal Meningitis [NCT00000708] | 120 participants | Interventional | Completed | ||||
| Fluconazole Prophylaxis of Thrush in AIDS [NCT00001542] | Phase 4 | 80 participants | Interventional | 1996-07-31 | Completed | ||
| Pharmacokinetics of a Fluconazole Loading Dose in Infants and Toddlers [NCT00797420] | Phase 1 | 13 participants (Actual) | Interventional | 2008-11-30 | Completed | ||
| Reducing Vaginal Infections in Women at Risk for HIV-1 [NCT00170430] | Phase 3 | 400 participants | Interventional | 2003-05-31 | Completed | ||
| Effects of Genotype on CYP2C9 Drug Interactions [NCT01061112] | 23 participants (Actual) | Observational | 2009-12-31 | Completed | |||
| A Phase Ib Study of Belinostat With RDHAP Chemotherapy (Dexamethasone, Cytarabine, Cisplatinum) in Adults With Relapsed or Refractory Diffuse Large B-cell Lymphoma [NCT02532192] | Phase 1 | 0 participants (Actual) | Interventional | 2015-12-31 | Withdrawn(stopped due to Withdrawal of study support.) | ||
| Evaluation of Serum Concentrations of Budesonide in Patients Treated for Gastrointestinal Graft-Versus-Host Disease and the Potential Interaction With Fluconazole or Voriconazole [NCT01950507] | Phase 1 | 15 participants (Actual) | Interventional | 2014-02-20 | Terminated(stopped due to Slow/Insufficient accrual) | ||
| Observational Prospective Multicenter Study to Evaluate the Infective Risk in Myelodysplastic Syndrome Patients: Antimicrobial Prophylaxis and Granulocyte Growth Factors. [NCT01951430] | 229 participants (Actual) | Observational | 2014-03-31 | Completed | |||
| Phase 3 Randomized Trial Comparing Fluconazole to Meglumine Antimoniate in the Treatment of Cutaneous Leishmaniasis Caused by L. Braziliensis and L. Guyanensis [NCT01953744] | Phase 3 | 53 participants (Actual) | Interventional | 2014-02-28 | Terminated(stopped due to Low cure rate in the study (fluconazole) group) | ||
| Randomized, Open Label, Non-inferiority Study of Micafungin Versus Fluconazole for the Korean Prevention of Invasive Fungal Disease in Living Donor Liver Transplant Recipients [NCT01974375] | Phase 3 | 172 participants (Anticipated) | Interventional | 2012-08-31 | Recruiting | ||
| Effect of Fluconazole, Clarithromycin, and Rifabutin on the Pharmacokinetics of Sulfamethoxazole and Dapsone and Their Hydroxylamine Metabolites [NCT00000826] | Phase 1 | 48 participants | Interventional | Completed | |||
| A Randomized Double Blind Protocol Comparing Amphotericin B With Flucytosine to Amphotericin B Alone Followed by a Comparison of Fluconazole and Itraconazole in the Treatment of Acute Cryptococcal Meningitis [NCT00000639] | 400 participants | Interventional | Completed | ||||
| A Phase IV Randomized Study of the Use of Fluconazole as Chronic Suppressive Therapy Versus Episodic Therapy in HIV Positive Subjects With Recurrent Oropharyngeal Candidiasis [NCT00000951] | Phase 4 | 948 participants | Interventional | Completed | |||
| Pharmacokinetics of Fluconazole Given Intravenously as Prophylaxis or Therapy to Patients With an Invasive Fungal Infection in the Intensive Care Unit (PACIFIC) [NCT02666716] | 20 participants (Actual) | Observational | 2015-05-31 | Completed | |||
| A 3-Part, Open-label Study to Assess the Pharmacokinetic Drug-Drug Interactions of Lemborexant When Coadministered With an Oral Contraceptive, Famotidine, or Fluconazole in Healthy Subjects [NCT03451110] | Phase 1 | 50 participants (Actual) | Interventional | 2018-02-05 | Completed | ||
| A Phase Iiib, Open-label, Randomized, Multi-center Study Of The Efficacy And Safety Of Anidulafungin Vs. Fluconazole, In The Treatment Of Subjects With Candidemia And/or Other Forms Of Invasive Candidiasis [NCT01176058] | Phase 3 | 17 participants (Actual) | Interventional | 2010-12-31 | Terminated(stopped due to See termination reason in detailed description.) | ||
| Assessment of the Treatment of the Severely Burned With Anabolic Agents on Clinical Outcomes, Recovery and Rehabilitation [NCT00675714] | Phase 2/Phase 3 | 1,126 participants (Actual) | Interventional | 2004-01-31 | Terminated(stopped due to At the request of the study site, this study has been closed and access to study-related data is unavailable. We are unable to submit the results-data.) | ||
| PTX3 Genetically Stratified Randomized Double-blinded Allocation Event-driven Clinical Trial for Antifungal Prophylaxis in Patients With Acute Myeloid Leukemia [NCT03828773] | 320 participants (Anticipated) | Interventional | 2019-02-11 | Recruiting | |||
| A Phase I/II Dose-Finding Study of High-Dose Fluconazole Treatment in AIDS-Associated Cryptococcal Meningitis [NCT00885703] | Phase 1/Phase 2 | 168 participants (Actual) | Interventional | 2010-04-16 | Completed | ||
| "Single-center, Randomized, Open-label, Two-way Crossover Study to Characterize Phenotyping Metrics of the Basel Cocktail After CYP Induction or Inhibition in Healthy Male Subjects" [NCT01386593] | Phase 1 | 16 participants (Actual) | Interventional | 2011-05-31 | Completed | ||
| Discontinuation of Primary and Secondary Prophylaxis for Opportunistic Infections in HIV-infected Patients Who Had CD4+ Cell Count <200 Cells/mm3 But Undetectable Plasma HIV-1 RNA [NCT01392430] | 74 participants (Actual) | Interventional | 2009-06-30 | Completed | |||
| Comparative,Randomized,Single-dose,2-way Crossover Bioavailability Study of Dr.Reddy's Laboratories Limited Fluconazole Tablets 200 mg and PFIZER (DIFLUCAN) 200 MG in Healthy Males Under Fasting Condition. [NCT01511770] | Phase 1 | 17 participants (Actual) | Interventional | 2002-08-31 | Completed | ||
| Oral Candidiasis in HIV Infected Individuals in Tanzania [NCT00553137] | Phase 4 | 220 participants (Actual) | Interventional | 2006-11-30 | Completed | ||
| A Phase 1, Open-label Study to Evaluate the Effect of a Dual CYP2C19 and CYP3A4 Inhibitor, Fluconazole, on the Pharmacokinetics of Fedratinib in Healthy Adult Subjects [NCT04702464] | Phase 1 | 29 participants (Actual) | Interventional | 2021-01-12 | Completed | ||
| A Phase 1, Open-Label, 4-Part, Fixed-Sequence Study to Assess the Effect of Itraconazole, a Strong CYP3A Inhibitor, the Effect of Fluconazole, a Moderate CYP3A/2C9 Inhibitor, the Effect of Rifampin, a Strong CYP3A Inducer, and the Effect of Rabeprazole, a [NCT05602597] | Phase 1 | 59 participants (Actual) | Interventional | 2022-06-01 | Completed | ||
| Open, Non-Comparative Study of Fluconazole in Patients With Coccidioidal Meningitis [NCT00002010] | 0 participants | Interventional | Completed | ||||
| Comparison of Fluconazole (UK-49,858) and Amphotericin B for Maintenance Treatment of Cryptococcal Meningitis in Patients With Acquired Immunodeficiency Syndrome [NCT00001017] | Phase 3 | 330 participants | Interventional | Completed | |||
| Prophylactic Annti-fungal Treatment in Severe Sepsis Patients With Perforations in SICU [NCT02941068] | Phase 2 | 223 participants (Actual) | Interventional | 2012-03-31 | Completed | ||
| Multicenter, Double-blind, Placebo-controlled Study to Evaluate the Efficacy and Safety of Fluconazole in Hypercalcicuric Patients With Increased 1.25(OH) 2D Levels [NCT04495608] | Phase 2 | 60 participants (Anticipated) | Interventional | 2021-01-13 | Recruiting | ||
| Clinical Study of Amphotericin B Colloidal Dispersion (ABCD) in the Treatment of Cryptococcal Meningitis [NCT05471063] | 30 participants (Anticipated) | Interventional | 2022-08-22 | Not yet recruiting | |||
| Diagnosis of Pulmonary Candidiasis [NCT00537888] | Phase 4 | 200 participants (Anticipated) | Interventional | 2007-09-30 | Recruiting | ||
| Translational PKPD Modeling of Anti-infective Drugs in Children Treated in Pediatric Units on the Example of Selected Antibiotics and Antifungals. [NCT05426499] | 150 participants (Anticipated) | Observational | 2021-10-01 | Active, not recruiting | |||
| Anidulafungin Versus Fluconazole for the Prevention of Invasive Fungal Infections in High-risk Liver Transplant Recipients: a Randomized, Double-blind Trial [NCT00841971] | Phase 4 | 200 participants (Actual) | Interventional | 2010-02-28 | Completed | ||
| Open, Non-Comparative Study of Intravenous and Oral Fluconazole in the Treatment of Acute Cryptococcal Meningitis [NCT00002040] | 0 participants | Interventional | Completed | ||||
| Pilot Study of Oral Fluconazole in the Treatment of Acute Cryptococcal Meningitis [NCT00002076] | 0 participants | Interventional | Completed | ||||
| Comparative Randomized Study of the Efficacy, Safety, and Toleration of Fluconazole Oral Suspension or Nystatin Oral Suspension in the Treatment of Patients With Oropharyngeal Candidiasis in Association With the Acquired Immunodeficiency Syndrome [NCT00002112] | 0 participants | Interventional | Completed | ||||
| A Randomized Comparative Multicenter Trial of Fluconazole and Ketoconazole in the Treatment of Esophageal Candidiasis in Immunocompromised Patients [NCT00002304] | 0 participants | Interventional | Completed | ||||
| [NCT00004938] | Phase 2 | 30 participants | Interventional | 1996-08-31 | Completed | ||
| Open-Label, Randomized Study to Estimate Safety, PK, and Efficacy of Oral Ibrexafungerp (SCY-078) vs. Standard-of-Care Following IV Echinocandin Therapy in the Treatment of Invasive Candidiasis in Hospitalized Nonneutropenic Adults [NCT02244606] | Phase 2 | 27 participants (Actual) | Interventional | 2014-09-30 | Completed | ||
| Management of Vaginal Complaints: A Pilot Study Within a Practice-Based Research Network [NCT00503542] | Early Phase 1 | 46 participants (Actual) | Interventional | 2007-02-28 | Completed | ||
| [NCT02275975] | Phase 1 | 20 participants (Actual) | Interventional | 2014-07-31 | Completed | ||
| Comparative,Randomized,Single-dose,2-way Crossover Bioavailability Study of Dr.Reddy's Laboratories Limited Fluconazole Tablets 200 mg and PFIZER (DIFLUCAN) 200 MG in Healthy Males Under Fed Condition. [NCT01511757] | Phase 1 | 15 participants (Actual) | Interventional | 2002-06-30 | Completed | ||
| Phase 3 Study of Antibiotic Prophylaxis Use Prior Emergent Surgery, Because of Acute Appendicitis [NCT01524081] | Phase 3 | 187 participants (Actual) | Interventional | 2008-07-31 | Completed | ||
| Double Blind Placebo Controlled Study of Fluconazole (UK-49,858) for Maintenance Treatment of Cryptococcal Meningitis in Patients With Acquired Immunodeficiency Syndrome [NCT00002294] | 0 participants | Interventional | Completed | ||||
| Operational Research for Cryptococcal Antigen Screening to Improve ART Survival [NCT01535469] | Phase 4 | 3,049 participants (Actual) | Interventional | 2012-07-01 | Completed | ||
| Multi-Center Evaluation of Fluconazole (UK-49,858) as Treatment for Acute Cryptococcal Meningitis in Patients Who Have Failed to Respond or Have Experienced Unacceptable Toxicity During Treatment With Amphotericin B [NCT00002306] | 0 participants | Interventional | Completed | ||||
| A Randomized Multicenter Study of the Efficacy, Safety, and Toleration of Fluconazole or Clotrimazole Troches in the Treatment of Patients With Oropharyngeal Candidiasis in Association With the Acquired Immunodeficiency Syndrome [NCT00002282] | 0 participants | Interventional | Completed | ||||
| A Phase III, Randomized, Double-Blind, Comparative Trial of FK463 Versus Fluconazole for Prophylaxis of Fungal Infections in Patients Undergoing a Hematopoetic Stem Cell Transplant [NCT00001937] | Phase 3 | 800 participants | Interventional | 1999-11-30 | Completed | ||
| Blood and Marrow Transplant Clinical Research Network [NCT00023530] | 0 participants | Interventional | 2001-09-30 | Completed | |||
| A Study to Assess the Effect of Concomitant Administration of Fluconazole on the Clinical Pharmacokinetics of Methadone [NCT00000788] | Phase 1 | 24 participants | Interventional | Completed | |||
| A Phase III, Double-Blind, Randomized, Multi-Center, Study of the Safety and Efficacy of Anidulafungin vs. Fluconazole in the Treatment of Patients With Candidemia and Other Forms of Invasive Candidiasis and Prevention of Complications. [NCT00056368] | Phase 3 | 256 participants (Actual) | Interventional | 2003-03-31 | Completed | ||
| A Randomized, Double-Blind, Placebo-Controlled, Dose-Ranging, Phase II Study of the Safety and Antifungal Activity of Subcutaneous Recombinant Interferon-Gamma 1b (rIFN-Gamma 1b) in Conjunction With Standard Therapy in Patients With Acute Cryptococcal Men [NCT00012467] | Phase 2 | 60 participants | Interventional | 2000-01-31 | Completed | ||
| A Randomized, Open Label, Comparative Multicenter Study Of Voriconazole Versus Conventional Amphotericin B Followed By Fluconazole In The Treatment Of Candidaemia In Non Neutropenic Subjects. [NCT00163111] | Phase 3 | 412 participants (Actual) | Interventional | 1998-09-30 | Completed | ||
| A Single Center, Open, Parallel, Comparative, Randomized Study of Micafungin (FK463) vs Fluconazole (Diflucan) in the Treatment of Invasive Candidiasis and Candidaemia (Protocol No: MCFGCAN-0301F-TW) [NCT00189709] | Phase 3 | 24 participants (Actual) | Interventional | 2004-08-31 | Completed | ||
| Effect of Fluconazole on the Levels of Anti-Saccharomyces Cerevisiae Antibodies (ASCA) After Surgical Resection for Crohn's Disease. Multicenter, Randomized, and Controlled in Two Parallel Groups Versus Placebo [NCT02997059] | Phase 2 | 35 participants (Actual) | Interventional | 2008-07-31 | Terminated(stopped due to Limited recourse to intestinal resection due to new management of CD) | ||
| A Randomized, Parallel-group Study of Terconazole Vaginal Suppository vs Fluconazole for the Treatment of Severe [NCT02180100] | Phase 4 | 140 participants (Actual) | Interventional | 2013-08-31 | Completed | ||
| Fundamental Modification of the Gut Microbiota in the Treatment of Refractory Crohn's Disease [NCT02765256] | Phase 2 | 8 participants (Actual) | Interventional | 2016-08-31 | Completed | ||
| Prediction of Potential Drug Interaction With CYP2C9 Substrate by Using Phenytoin Metabolic Ratio as a Marker of Its Activity in-Vivo. [NCT00226538] | 16 participants | Interventional | 1999-08-31 | Completed | |||
| An Open-Label, Fixed Sequence Study in Healthy Subjects to Assess the Pharmacokinetics of Acalabrutinib and Its Active Metabolite, ACP-5862, When Administered Alone and in Combination With Moderate CYP3A4 Inhibitors Fluconazole or Isavuconazole [NCT05140096] | Phase 1 | 30 participants (Actual) | Interventional | 2020-01-03 | Completed | ||
| A Multicenter Cohort Study of the Short and Long-term Safety of Micafungin and Other Parenteral Antifungal Agents [NCT01686607] | 40,110 participants (Actual) | Observational | 2012-10-01 | Completed | |||
| A Randomised Controlled Trial of Single Dose Tinidazole+Fluconazole Versus Longer Courses of Metronidazole+Clotrimazole in the Management of West African Women With Vaginal Discharge [NCT00313131] | Phase 3 | 1,524 participants | Interventional | 2004-01-31 | Completed | ||
| Randomized, Controlled Trial of SCH 56592 Oral Suspension Versus Fluconazole Suspension in the Treatment of Oropharyngeal Candidiasis (OPC) in HIV-Positive Patients [NCT00002446] | Phase 3 | 300 participants | Interventional | 1998-08-31 | Completed | ||
| A Randomized Comparative Study of Fluconazole Versus Micafungin for the Treatment of Candida Bloodstream Infection in Non-Neutropenic Patients [NCT00304772] | Phase 4 | 0 participants (Actual) | Interventional | 2006-08-31 | Withdrawn(stopped due to Subjects were not recruited as intended.) | ||
| [NCT01683760] | Phase 2 | 80 participants (Actual) | Interventional | 2012-09-30 | Completed | ||
| A Phase 1, Open-label Study to Evaluate the Effect of Fluconazole, Bupropion, or Itraconazole on the Pharmacokinetics and Safety of BMS-986235 [NCT04464577] | Phase 1 | 0 participants (Actual) | Interventional | 2021-04-01 | Withdrawn(stopped due to Business objectives have changed.) | ||
| Prospective Pilot Study to Evaluate a Standardized Management of Cryptococcal Meningitis in Patients Infected With HIV in Sub-Saharan Africa Involving an Initial Combination Therapy With Fluconazole and Flucytosine in High Doses, Complemented by Repeat Lu [NCT01715922] | Phase 2/Phase 3 | 41 participants (Actual) | Interventional | 2012-05-31 | Active, not recruiting | ||
| Vietnam Cryptococcal Retention in Care Study (CRICS) - Version 2.1 [NCT03267407] | 1,184 participants (Actual) | Observational | 2015-08-14 | Active, not recruiting | |||
| A Clinical Drug-Drug Interaction Study to Evaluate the Effect of a Proton Pump Inhibitor, a Combined P-gp/CYP3A4 Inhibitor, and a CYP2C9 Inhibitor on the Pharmacokinetics of Vismodegib [NCT01772290] | Phase 1 | 92 participants (Actual) | Interventional | 2013-02-28 | Completed | ||
| Reduction of Early mortALITY in HIV-infected African Adults and Children Starting Antiretroviral Therapy: a Randomised Controlled Trial [NCT01825031] | Phase 3 | 1,805 participants (Actual) | Interventional | 2013-06-30 | Completed | ||
| An Open Label Randomized Controlled Phase IIb Trial to Determine the Safety of Oral Fluconazole in Combination With Flucytosine as Compared to Fluconazole Alone [NCT01562132] | Phase 2 | 6 participants (Actual) | Interventional | 2013-09-30 | Terminated(stopped due to Stopped in accordance with pre-specified stopping rules for poor recruitment.) | ||
| A Phase 2A, Randomized, Double-Blind, Dose Ranging Study to Evaluate the Efficacy and Safety of VT-1161 Oral Tablets Compared to Fluconazole in the Treatment of Patients With Moderate to Severe Acute Vulvovaginal Candidiasis [NCT01891331] | Phase 2 | 55 participants (Actual) | Interventional | 2013-08-31 | Completed | ||
| Invasive Fungal Infection in Liver Transplant Recipients: A Randomized Double-Blind Trial Comparing AmBisome and Fluconazole in the High Risk Group and an Observational Cohort Study in the Low Risk [NCT00001107] | Phase 4 | 500 participants | Interventional | Completed | |||
| A Double-Blind, Placebo-Controlled Study of Fluconazole in the Prevention of Active Coccidioidomycosis and Other Systemic Fungal Infections in HIV-Infected Patients Living in the Coccidioidal Endemic Area [NCT00002325] | 0 participants | Interventional | Completed | ||||
| Fluconazole Versus Amphotericin B: A Prospective, Randomized, Multicenter Study for Therapy of Fungal Infection [NCT00002277] | Phase 3 | 0 participants | Interventional | Completed | |||
| Pilot Study to Determine the Feasibility of Fluconazole for Induction Treatment and Suppression of Relapse of Histoplasmosis in Patients With the Acquired Immunodeficiency Syndrome [NCT00000627] | 90 participants | Interventional | Completed | ||||
| Fluconazole Pharmacokinetics, Including Bioavailability, in Obese Subjects After an Intravenous and Oral Administration (FOLIA) [NCT04122560] | Phase 4 | 25 participants (Actual) | Interventional | 2019-11-30 | Completed | ||
| Non-Comparative Study of Fluconazole in Patients With Serious Mycoses and Who Cannot Be Treated With Conventional Antifungal Therapy [NCT00002038] | 0 participants | Interventional | Completed | ||||
| A Multicenter Comparison of Fluconazole (UK-49,858) and Amphotericin B as Treatment for Acute Cryptococcal Meningitis [NCT00002068] | 0 participants | Interventional | Completed | ||||
| Multicenter Comparison of Fluconazole (UK-49,858) and Amphotericin B as Maintenance Treatment for the Prevention of Relapse of Cryptococcal Meningitis in Patients With Acquired Immunodeficiency Syndrome [NCT00002074] | 0 participants | Interventional | Completed | ||||
| A Randomized Study of Daily and Intermittent Prophylactic Regimens for the Prevention of Disseminated Mycobacterium Avium Complex (MAC) and Fungal Infections in HIV-Infected Patients [NCT00002122] | Phase 3 | 720 participants | Interventional | Completed | |||
| Beijing Chilrens' Hospital [NCT05775692] | 150 participants (Anticipated) | Observational [Patient Registry] | 2020-01-01 | Recruiting | |||
| Physiology and Pathologic Role of Endothelium-Derived Hyperpolarizing Factor in Humans [NCT00166166] | Phase 2 | 174 participants (Actual) | Interventional | 2002-07-31 | Terminated(stopped due to Limited clinical staff) | ||
| A Phase 3, Multicenter, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of Oral Ibrexafungerp (SCY-078) Compared to Placebo in Subjects With Recurrent Vulvovaginal Candidiasis (VVC) [NCT04029116] | Phase 3 | 440 participants (Actual) | Interventional | 2019-10-21 | Completed | ||
| A Non-Randomized, Open-Label, Drug-Drug Interaction Study to Evaluate the Effects of Fluconazole on the Pharmacokinetics and Safety of EDP-938 in Healthy Subjects [NCT04871724] | Phase 1 | 24 participants (Actual) | Interventional | 2021-03-12 | Completed | ||
| A Phase II Randomized Trial of Amphotericin B Alone or Combined With Fluconazole in the Treatment of AIDS-Associated Cryptococcal Meningitis [NCT00145249] | Phase 2 | 143 participants (Actual) | Interventional | 2005-05-31 | Completed | ||
| Prospective Studies of Vaginal Yeast and Microbiome Related to Vulvovaginal Candidiasis in Canadian Females [NCT04930107] | Early Phase 1 | 105 participants (Anticipated) | Interventional | 2021-12-07 | Recruiting | ||
| Dexamethasone in Cryptococcal Meningitis [NCT00000776] | Phase 2 | 36 participants | Interventional | Completed | |||
| Randomized, Controlled, Double-Blind Study of Itraconazole Oral Solution Versus Fluconazole Tablets for the Treatment of Esophageal Candidiasis. [NCT00002132] | 0 participants | Interventional | Completed | ||||
| Multicenter Comparison of Fluconazole (UK-49,858) and Amphotericin B as Treatment for Acute Cryptococcal Meningitis [NCT00002305] | 0 participants | Interventional | Completed | ||||
| An Open, Non-Comparative Study of Intravenous and Oral Fluconazole in the Treatment of Acute Cryptococcal Meningitis [NCT00002077] | 0 participants | Interventional | Completed | ||||
| A Pilot Study of Fluconazole Plus Flucytosine for the Treatment of AIDS Patients With Acute Cryptococcal Meningitis. [NCT00002113] | 64 participants | Interventional | Completed | ||||
| A PHASE II/III PILOT STUDY OF THE EFFECTS OF PROPHYLACTIC FLUCONAZOLE THERAPY ON MUCOSITIS IN PATIENTS UNDERGOING RADIATION TREATMENT FOR HEAD AND NECK CANCER [NCT00002533] | Phase 2/Phase 3 | 0 participants | Interventional | 1993-02-28 | Completed | ||
| Association of Candida and Antifungal Therapy With Pro-inflammatory Cytokines in Oral Leukoplakia- A Pilot Study [NCT04712929] | 90 participants (Actual) | Observational | 2018-11-01 | Completed | |||
| [NCT00004808] | Phase 2 | 78 participants | Interventional | 1991-09-30 | Completed | ||
| A Randomized, Comparative Study of Itraconazole Versus Fluconazole for Prevention of Aspergillus Infections in Peripheral Blood Stem Cell and Marrow Transplant Recipients [NCT00003883] | Phase 3 | 578 participants (Anticipated) | Interventional | 1998-10-31 | Completed | ||
| A Phase 1 Study to Evaluate the Effects of Fluconazole and Itraconazole CYP3A-Mediated Inhibition on the Pharmacokinetics, Safety, and Tolerability of MLN4924 in Patients With Advanced Solid Tumors [NCT02122770] | Phase 1 | 51 participants (Actual) | Interventional | 2014-04-01 | Completed | ||
| Multicenter Comparison of Fluconazole (UK-49,858) and Amphotericin B as Treatment for Acute Cryptococcal Meningitis [NCT00002075] | 0 participants | Interventional | Completed | ||||
| An Open Multicenter Trial of Fluconazole Oral Suspension in the Treatment of Esophageal Candidiasis in Immunocompromised Patients [NCT00002339] | Phase 3 | 100 participants | Interventional | Completed | |||
| A Multicenter Open-label Non-comparative Study Of Fluconazole For The Treatment Of Vulvovaginal Candidiasis. [NCT01806623] | Phase 3 | 157 participants (Actual) | Interventional | 2013-03-05 | Completed | ||
| Cryptococcal Antigen Screening Plus Sertraline [NCT03002012] | Phase 3 | 22 participants (Actual) | Interventional | 2017-11-15 | Terminated(stopped due to SAEs with n=1 serotonin syndrome, n=2 SAEs after sertraline interruption.) | ||
| A FIRST-IN-HUMAN PHASE 1, DOSE ESCALATION, SAFETY AND PHARMACOKINETIC STUDY OF PF-06647020 IN ADULT PATIENTS WITH ADVANCED SOLID TUMORS [NCT02222922] | Phase 1 | 138 participants (Actual) | Interventional | 2014-10-17 | Completed | ||
| Effect of Blue Light Emitting Diode Therapy on Recurrent Vulvovaginal Candidiasis [NCT05795491] | 60 participants (Anticipated) | Interventional | 2023-04-30 | Enrolling by invitation | |||
| A Mono-centric, No-profit, Case-control Study With Daily Oral Supplementation of Zinc Sulphate After Autologous Stem Cell Transplantation in Patients Affected by Multiple Myeloma [NCT03159845] | Phase 2 | 20 participants (Anticipated) | Interventional | 2014-01-01 | Completed | ||
| A Randomized Trial of Tamoxifen Combined With Amphotericin B and Fluconazole for Cryptococcal Meningitis [NCT03112031] | Phase 2 | 50 participants (Actual) | Interventional | 2017-10-10 | Completed | ||
| A Single-centre, Open, Single-dose, Self-control Study to Investigate the Effect of Fluconazole on the Pharmacokinetics of Pyrotinib in Healthy Chinese Adult Subjects. [NCT04850651] | Phase 1 | 18 participants (Actual) | Interventional | 2021-04-16 | Completed | ||
| A RCT for Chlorhexidine Gluconate as Treatment and Prophylaxis for Recurrent Vulvovaginal Candidiasis [NCT05059145] | Phase 2 | 60 participants (Anticipated) | Interventional | 2022-04-27 | Recruiting | ||
| A Multicenter, Randomized, Double-Blind, Phase II Study to Evaluate the Safety, Tolerance and Efficacy of Multiple Doses of SCH 56592 Versus Fluconazole in the Treatment of Oropharyngeal Candidiasis (OPC) in HIV-Positive Patients [NCT00002399] | Phase 2 | 500 participants | Interventional | Completed | |||
| Pharmacogenetics of Warfarin Induction and Inhibition [NCT01447511] | 39 participants (Actual) | Interventional | 2009-05-31 | Completed | |||
| An Case-controlled Randomized Study to the Efficacy of Clotrimazole Vaginal Tablet vs Fluconazole for Severe Vulvovaginal Candidiasis [NCT02180828] | Phase 4 | 240 participants (Actual) | Interventional | 2014-07-31 | Completed | ||
| Study on the Pharmacokinetics of Fluconazole on Single-center, One-arm, Open and Fixed Sequences of Fluzoparib in Healthy Male Subjects [NCT04193319] | Phase 1 | 20 participants (Actual) | Interventional | 2019-07-19 | Completed | ||
| Immunogenicity and Safety Trial of Quadrivalent Influenza Vaccine Administered by Intradermal Route in Adult Subjects Aged 18 Through 64 Years [NCT01712984] | Phase 3 | 3,360 participants (Actual) | Interventional | 2012-10-31 | Completed | ||
| A Randomized, Double-Blind, Double-Dummy, Parallel-Group, Fluconazole Controlled, Multicenter Phase III Clinical Study to Evaluate the Efficacy and Safety of SHR8008 vs. Fluconazole in Subjects With Acute Vulvovaginal Candidiasis (VVC) [NCT04956419] | Phase 3 | 322 participants (Actual) | Interventional | 2021-04-24 | Active, not recruiting | ||
| Randomized Controlled Trial to Assess the Effectiveness of a Zinc-containing Vaginal Gel and Fluconazole on Treatment and Recurrence of Vulvovaginal Candidiasis. [NCT05895162] | 76 participants (Anticipated) | Interventional | 2023-06-10 | Recruiting | |||
| A Randomized, Double-Blind, Double-Dummy, Parallel Fluconazole Controlled, Multicenter Phase III Clinical Study to Evaluate the Efficacy and Safety of SHR8008 vs. Fluconazole in Subjects With Recurrent Vulvovaginal Candidiasis (RVVC) [NCT05074602] | Phase 3 | 196 participants (Anticipated) | Interventional | 2021-09-14 | Recruiting | ||
| A Phase 1, Open-Label, Drug-Drug Interaction Study to Evaluate the Effects of Multiple Oral Doses of Fluconazole and Atorvastatin on the Pharmacokinetics of a Single Oral Dose of TAK-385 in Healthy Subjects [NCT02093390] | Phase 1 | 40 participants (Actual) | Interventional | 2014-03-31 | Completed | ||
| An Open-Label Pilot Study of Fundamental Modification of the Gut Microbiota in the Treatment of Refractory Crohn's Disease [NCT03476317] | Phase 2 | 10 participants (Actual) | Interventional | 2018-07-12 | Completed | ||
| Endothelial Derived Hyperpolarization Factor and Regulation of Cerebral and Muscle Blood Flow [NCT05176379] | Phase 4 | 30 participants (Anticipated) | Interventional | 2022-02-19 | Recruiting | ||
| Single Dose Crossover Comparative Bioavailability Study of Fluconazole 200 mg Tablets Versus Diflucan® 200 mg Hard Capsules in Healthy Adult Subjects Under Fasting Conditions [NCT04038008] | Phase 1 | 26 participants (Actual) | Interventional | 2019-07-26 | Completed | ||
| Phase IIb/III Parallel-arm, Random., Active-controlled, Double-blind, Double-dummy, Multicenter, Non-inferiority Study in Patients With RVVC to Compare Efficacy, Safety and Tolerability of Topically Administered ProF-001 to Oral Fluconazole [NCT04734405] | Phase 2/Phase 3 | 432 participants (Anticipated) | Interventional | 2019-10-01 | Active, not recruiting | ||
| The Effect of Ketoconazole or Fluconazole on the Pharmacokinetics of Baricitinib in Healthy Subjects [NCT01924299] | Phase 1 | 36 participants (Actual) | Interventional | 2013-08-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||