Page last updated: 2024-08-07 16:34:08
Nociceptin receptor
A nociceptin receptor that is encoded in the genome of rat. [OMA:P35370, PRO:DNx]
Synonyms
Kappa-type 3 opioid receptor;
KOR-3;
Orphanin FQ receptor;
ROR-C;
XOR1
Research
Bioassay Publications (5)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 5 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Compounds (2)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| nociceptin | Rattus norvegicus (Norway rat) | IC50 | 0.0006 | 5 | 9 |
Drugs with Activation Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| prednisolone | Rattus norvegicus (Norway rat) | EC50 | 0.0034 | 1 | 1 |
| nociceptin | Rattus norvegicus (Norway rat) | EC50 | 0.0160 | 6 | 9 |
| nociceptin | Rattus norvegicus (Norway rat) | Kd | 0.0004 | 5 | 5 |
Spare interactions of highly potent [Arg(14),Lys(15)]nociceptin for cooperative induction of ORL1 receptor activation.Bioorganic & medicinal chemistry, , Dec-01, Volume: 17, Issue:23, 2009
Synergistic effect of basic residues at positions 14-15 of nociceptin on binding affinity and receptor activation.Bioorganic & medicinal chemistry, , Oct-15, Volume: 16, Issue:20, 2008
Synthesis and biological activity of nociceptin/orphanin FQ analogues substituted in position 7 or 11 with Calpha,alpha-dialkylated amino acids.Bioorganic & medicinal chemistry, , Jul-01, Volume: 15, Issue:13, 2007
ORL1 receptor ligands: structure-activity relationships of 8-cycloalkyl-1-phenyl-1,3,8-triaza-spiro[4.5]decan-4-ones.Bioorganic & medicinal chemistry letters, , Apr-17, Volume: 10, Issue:8, 2000