sulforaphane profile

Sulforaphane is a naturally occurring organosulfur compound found in cruciferous vegetables such as broccoli, kale, Brussels sprouts, and cauliflower. It is a potent inducer of phase II detoxification enzymes, particularly glutathione S-transferase (GST). Sulforaphane is synthesized from the glucosinolate glucoraphanin through the action of the enzyme myrosinase, which is released when the plant tissue is damaged. The compound is considered a phytochemical and has shown promise in various research studies. '

sulforaphane: from Cardaria draba L. [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

sulforaphane : An isothiocyanate having a 4-(methylsulfinyl)butyl group attached to the nitrogen. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

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Flora	Rank	Flora Definition	Family	Family Definition
Draba	genus	[no description available]	Brassicaceae	A plant family of the order Capparales, subclass Dilleniidae, class Magnoliopsida. They are mostly herbaceous plants with peppery-flavored leaves, due to gluconapin (GLUCOSINOLATES) and its hydrolysis product butenylisotrhiocyanate. The family includes many plants of economic importance that have been extensively altered and domesticated by humans. Flowers have 4 petals. Podlike fruits contain a number of seeds. Cress is a general term used for many in the Brassicacea family. Rockcress is usually ARABIS; Bittercress is usually CARDAMINE; Yellowcress is usually RORIPPA; Pennycress is usually THLASPI; Watercress refers to NASTURTIUM; or RORIPPA or TROPAEOLUM; Gardencress refers to LEPIDIUM; Indiancress refers to TROPAEOLUM.[MeSH]

ID Source	ID
PubMed CID	5350
CHEMBL ID	48802
CHEBI ID	47807
SCHEMBL ID	105202
MeSH ID	M0066957

Synonym
dl-sulforaphane, >=90% (hplc), synthetic, liquid
butane, 1-isothiocyanato-4-(methylsulfinyl)-
ccris 7221
SFN ,
4478-93-7
sulforaphane
CHEBI:47807 ,
4-isothiocyanatobutyl methyl sulfoxide
r,s-sulforaphane ,
sulforafan
d,l-sulforaphane
1-isothiocyanato-4-(methylsulfinyl)butane
sulforaphane, (r)-
sulphoraphane
CHEMBL48802
4-(methylsulfinyl)butyl isothiocyanate
dl-sulforaphane
1-isothiocyanato-4-methylsulfinylbutane
nsc-749790
nsc749790
1-isothiocyanato-4-(methylsulfinyl)-butane
AKOS006282481
butane, 1-isothiocyanato-4-[(s)-methylsulfinyl]-
FT-0674751
FT-0674748
FT-0674750
FT-0674749
unii-41684wl1gl
nsc 749790
41684wl1gl ,
BRD-A58955223-001-02-0
S5771
gtpl6569
isothiocyanic acid, 4-(methylsulfinyl)butyl ester
sulforaphane, (+/-)-
(+/-)-sulforaphane
sulforaphane (+/-)-form [mi]
SCHEMBL105202
1-isothiocyanato-4-(methylsulfinyl)butane #
AC-34421
Q-100160
CS-7809
DTXSID8036732
bdbm50073654
4-methylsulfinyl butyl isothiocyanate
sulforathane
F17072
HY-13755
Q424489
mfcd00198068
BCP31547
(r)-sulforaphane;(-)-sulforaphane;4-methylsulfinylbutyl isothiocyanate
HMS3746M17
A912495
(s)-1-isothiocyanato-4-(methylsulfinyl)butane
1-isothiocyanato-4-methylsulfinyl-butane
4-(methylsulfinyl)-butyl isothiocyanate
s)-sulforaphane
U0142
Z1198151975

Excerpt	Reference	Relevance
"Sulforaphane (SFN) is an isothiocyanate with anti-arthritic and immuno-regulatory activities, supported by the downregulation of NF-κB pathway, reduction on metalloproteinases expression and prevention of cytokine-induced cartilage degeneration implicated in OA progression. "	( Sulforaphane-loaded hyaluronic acid-poloxamer hybrid hydrogel enhances cartilage protection in osteoarthritis models. Alberto-Silva, C; Ambrosio, FN; Christoffolete, MA; de Araujo, DR; Ferraraz, DC; Franco, MKKD; Kent, B; Lombello, CB; Monteiro do Nascimento, MH; Nascimento-Sales, M; Querobino, SM; Windisch-Neto, H; Yokaichiya, F, 2021)	3.51
"Sulforaphane (SFN) is an important diet-derived cancer prevention agent that is known to possess a reactive isothiocyanate group and has potent anticancer activity."	( Sulforaphane covalently interacts with the transglutaminase 2 cancer maintenance protein to alter its structure and suppress its activity. Adhikary, G; Eckert, RL; Gates, EWJ; Godoy-Ruiz, R; Keillor, JW; Lakowicz, JR; Puranik, P; Rorke, EA; Szmacinski, H; Weber, DJ, 2022)	2.89
"L-sulforaphane (LSF) is an isothiocyanate derived from cruciferous vegetables that has long been known for its anticarcinogenic, antioxidant and anti-inflammatory effects. "	( The effects of the dietary compound L-sulforaphane against respiratory pathogens. Anderson, J; Do, LAH; Higgins, RA; Karagiannis, TC; Licciardi, PV; Luwor, RB; Mazarakis, N; Snibson, KJ; Toh, ZQ, 2021)	1.61
"Sulforaphane (SFN) is a hydrolysate of glucosinolate (GLS) that is found in large quantities in cruciferous vegetables."	( Sulforaphane Regulates Glucose and Lipid Metabolisms in Obese Mice by Restraining JNK and Activating Insulin and FGF21 Signal Pathways. Li, X; Liu, J; Lu, Y; Tian, S; Wang, J; Wang, Y, 2021)	2.79
"Sulforaphane (SFN) is a kind of isothiocyanate from cruciferous vegetables with extensive anti-tumor activity. "	( mTOR inhibitor PP242 increases antitumor activity of sulforaphane by blocking Akt/mTOR pathway in esophageal squamous cell carcinoma. Hou, G; Li, Y; Lu, Z; Wang, P; Wei, H; Xu, Y; Zhang, Y; Zhao, W, 2022)	2.41
"Sulforaphane (SFN) is a therapeutic phytochemical agent for many health conditions. "	( GSH Levels Serve As a Biological Redox Switch Regulating Sulforaphane-Induced Cell Fate in Human Lens Cells. Bernuzzi, F; Bowater, RP; Huynh, TPN; Saha, S; Wormstone, IM, 2021)	2.31
"Sulforaphane (SFN) is a natural plant extract that is known to have anti-inflammatory and antioxidant properties."	( Sulforaphane inhibits cytokine-stimulated chemokine and adhesion molecule expressions in human corneal fibroblasts: Involvement of the MAPK, STAT, and NF-κB signaling pathways. Li, B; Liu, P; Liu, Y; Yang, C; Yang, X; Zhao, X, 2022)	2.89
"Sulforaphane (SFN) is a natural exogenous antioxidant from cruciferous vegetables already shown to improve cardiac function in cardiovascular diseases. "	( Sulforaphane Effects on Cardiac Function and Calcium-Handling-Related Proteins in 2 Experimental Models of Heart Disease: Ischemia-Reperfusion and Infarction. Belló-Klein, A; Cordero, EA; Corssac, GB; Fernandes, RO; Luz de Castro, A; Poletto Bonetto, JH; Sander da Rosa Araujo, A; Schenkel, PC, 2022)	3.61
"Sulforaphane (SFN) is an isothiocyanate (ITC) derived from a glucosinolate, glucoraphinin found in cruciferous vegetables. "	( Biphasic effect of sulforaphane on angiogenesis in hypoxia Bao, Y; Chen, F; Li, D; Liu, S; Tang, M; Wang, P; Wang, Y; Wang, Z; Zhang, Y; Zheng, X, 2022)	2.49
"Sulforaphane (SFN) is an organosulfur compound extracted from cruciferous vegetables and has biological effects. "	( Sulforaphane induces cell differentiation, melanogenesis and also inhibit the proliferation of melanoma cells. Eom, YS; Kim, SJ; Shah, FH, 2022)	3.61
"Sulforaphane (SFN) is an isothiocyanate found in cruciferous vegetables and sodium butyrate (NaB) is a short-chain fatty acid produced by gut microbiota."	( Combinatorial epigenetic mechanisms of sulforaphane, genistein and sodium butyrate in breast cancer inhibition. Sharma, M; Tollefsbol, TO, 2022)	1.71
"Sulforaphane (SFN) is a potent anticancer agent which could protect the skin from ultraviolet (UV) radiation-induced insults. "	( UVB Drives Metabolic Rewiring and Epigenetic Reprograming and Protection by Sulforaphane in Human Skin Keratinocytes. Dina Kuo, HC; Kong, AN; Li, S; Sargsyan, D; Wang, L; Wu, R, 2022)	2.39
"Sulforaphane (SFN) is a natural antioxidant extracted from the cruciferous vegetables."	( Sulforaphane alleviates high fat diet-induced insulin resistance via AMPK/Nrf2/GPx4 axis. Gao, Y; Liu, J; Ma, X; Thring, RW; Tong, H; Wu, M; Wu, Q; Zhang, Y; Zhang, Z; Zhu, J, 2022)	2.89
"Sulforaphane is a natural compound obtained from cruciferous vegetables."	( Therapeutic effects of sulforaphane in ulcerative colitis: effect on antioxidant activity, mitochondrial biogenesis and DNA polymerization. Al-Gayyar, MMH; Alattar, A; Alshaman, R, 2022)	1.75
"Sulforaphane (SFN) is a hormetin that activates the antioxidant and anti-inflammatory responses."	( Long-term sulforaphane-treatment restores redox homeostasis and prevents cognitive decline in middleaged female and male rats, but cannot revert previous damage in old animals. Gómez-González, B; Hernández-Arciga, U; Königsberg, M; Librado-Osorio, R; López-Cervantes, SP; López-Diazguerrero, NE; Luna-López, A; Salas-Venegas, V; Santín-Márquez, R; Toledo-Pérez, R, 2022)	1.85
"Sulforaphane (SFN) is a naturally occurring isothiocyanate that is abundant in many cruciferous vegetables, such as broccoli and cauliflower, and it has been observed to exert numerous biological activities. "	( Sulforaphane Regulates eNOS Activation and NO Production via Src-Mediated PI3K/Akt Signaling in Human Endothelial EA.hy926 Cells. Cai, B; Jung, YD; Khoi, PN; Sah, DK; Zhang, Y, 2022)	3.61
"Sulforaphane (SFN) is a natural isothiocyanate extracted from cruciferous vegetables with promising anti-inflammatory and anti-oxidative activities."	( Sulforaphane alleviated vascular remodeling in hypoxic pulmonary hypertension via inhibiting inflammation and oxidative stress. Cheng, K; Gong, M; Ji, Y; Li, J; Liu, L; Liu, Q; Pan, J; Pei, Y; Sun, J; Tang, Q; Wang, D; Wang, R; Wu, N; Yuan, Y; Zhang, C; Zheng, X, 2023)	3.07
"Sulforaphane (SFN) is a promising cancer prevention and treatment agent that strongly suppresses the cutaneous squamous cell carcinoma (CSCC) cell cancer phenotype. "	( Sulforaphane inhibits CD44v6/YAP1/TEAD signaling to suppress the cancer phenotype. Adhikary, G; Chen, X; Eckert, RL; Ma, E; Naselsky, W; Newland, JJ; Xu, W, 2023)	3.8
"Sulforaphane (SFN) is an isothiocyanate derived from cruciferous vegetables that has therapeutic efficacy in numerous animal models of human disease, including mouse models of retinal degeneration. "	( Sulforaphane recovers cone function in an Nrf2-dependent manner in middle-aged mice undergoing RPE oxidative stress. Boulton, ME; Plafker, KS; Plafker, SM; Qi, X; Walton, DA, 2022)	3.61
"Sulforaphane is a bioactive metabolite with anti-inflammatory activity and is derived from the glucosinolate glucoraphanin, which is highly abundant in broccoli sprouts. "	( A steamed broccoli sprout diet preparation that reduces colitis via the gut microbiota. Chen, GY; Eaton, KA; Ho, S; Holman, J; Li, Y; McKinstry, D; Mendoza-Castrejon, J; Sun, D; Trindade, BC; Wells, E; Wen, B; Yuan, H; Zhang, T, 2023)	2.35
"Sulforaphane (SFN) is a naturally occurring molecule present in plants from Brassica family. "	( Conducting bioinformatics analysis to predict sulforaphane-triggered adverse outcome pathways in healthy human cells. Antonijević, B; Baralić, K; Bozic, D; Bulat, Z; Ćurčić, M; Djordjević, AB; Miljaković, EA; Živančević, K; Đukić-Ćosić, D, 2023)	2.61
"Sulforaphane (SF) is a phytochemical that exhibits a neuroprotective potential."	( Neurotherapeutic efficacy of loaded sulforaphane on iron oxide nanoparticles against cuprizone-induced neurotoxicity: role of MMP-9 and S100β. Beherei, HH; El-Sayed, SAM; Ibrahim Fouad, G; Mabrouk, M; Rizk, MZ, 2023)	1.91
"Sulforaphane (SFN) is a secondary metabolite of crucifers."	( SstF, a novel sulforaphane-sensing transcription factor of Xanthomonas campestris, is required for sulforaphane tolerance and virulence. Guo, B; Hou, R; Li, K; Liu, F; Tang, B; Wang, B; Wu, G; Xu, Z; Zhao, Y, 2023)	1.99
"Sulforaphane (SFN) is an isothiocyanate of vegetable origin with potent antioxidant and immunomodulatory properties. "	( Sulforaphane Reduces the Chronic Inflammatory Immune Response of Human Dendritic Cells. Alba, G; Brasal-Prieto, M; Cejudo-Guillen, M; Dakhaoui, H; Fernandez-Prades, L; Granados, B; Lopez-Enriquez, S; Martin, V; Montserrat-de la Paz, S; Palomares, F; Santa-Maria, C; Sobrino, F, 2023)	3.8
"Sulforaphane is a naturally occurring phytonutrient found most densely within cruciferous vegetables."	( Preeclampsia to COVID-19: A journey towards improved placental and vascular function using sulforaphane. Fields, NJ; Marshall, SA; Nisi, A; Palmer, KR, 2023)	1.85
"Sulforaphane is a potent dietary activator of the transcription factor Nuclear factor erythroid-like 2 (NRF2), the master regulator of antioxidant cell capacity responsible for inducing cytoprotective genes, but its role in glucose homeostasis remains unclear."	( Sulforaphane rewires central metabolism to support antioxidant response and achieve glucose homeostasis. Bernuzzi, F; Hiller, K; Korcsmaros, T; Ludwig, T; Maertens, A; Mithen, RF; Saha, S; Traka, MH; Troncoso-Rey, P, 2023)	3.07
"Sulforaphane (SFN) is a naturally bioactive phytocompound derived from cruciferous vegetables that has been shown to possess cytoprotective properties."	( Sulforaphane alleviates the meiosis defects induced by 3-nitropropionic acid in mouse oocytes. Ding, LR; Li, WJ; Liu, HL; Shen, M; Zhang, X, 2023)	3.07
"Sulforaphane (SFN) is a naturally occurring compound found in cruciferous vegetables such as broccoli and cauliflower. "	( Sulforaphane's Multifaceted Potential: From Neuroprotection to Anticancer Action. Allen, AR; Otoo, RA, 2023)	3.8
"Sulforaphane (SFN) is an indirect antioxidant that induces phase II detoxification enzymes and antioxidant genes."	( Sulforaphane attenuates irradiation induced testis injury in mice. Duan, N; Gao, Z; Liu, X; Liu, Y; Ran, Y; Xue, B, 2023)	3.07
"Sulforaphane (SFN) is an organosulfur compound obtained from cruciferous plants, such as broccoli and mustard, and it has the potential to treat breast cancer."	( Targets and mechanisms of sulforaphane derivatives obtained from cruciferous plants with special focus on breast cancer - contradictory effects and future perspectives. Abiri, A; Afzalipour Khoshkbejari, M; Amanollahi, S; Cho, CH; Jabbarzadeh Kaboli, P; Li, M; Mohammadi, M; Mokhtarian, R; Shen, J; Vazifemand, R; Wu, X; Xiao, Z; Yazdi Sani, S; Zhao, Y, 2020)	1.58
"Sulforaphane is a sulfur-rich dietary phytochemical which has several activities such as antioxidant, anti-inflammatory, and anti-tumor via multiple targets and various mechanisms."	( Emerging promise of sulforaphane-mediated Nrf2 signaling cascade against neurological disorders. Abdel-Daim, MM; Ahmad, J; Aleya, L; Jakaria, M; Mamun, AA; Mathew, B; Rahman, MA; Thangapandiyan, S; Uddin, MS, 2020)	1.6
"Sulforaphane (SFN) is a promising bioactive compound for epigenetic targeting therapy."	( Transcriptome and DNA methylation changes modulated by sulforaphane induce cell cycle arrest, apoptosis, DNA damage, and suppression of proliferation in human liver cancer cells. Aissa, AF; Antunes, LMG; De Grandis, RA; Dos Santos, PWDS; Machado, ART; Morselli, M; Pellegrini, M; Ribeiro, DL; Tuttis, K, 2020)	1.53
"Sulforaphane (SFE) is a traditional Chinese herbal medicine."	( Sulforaphane: Expected to Become a Novel Antitumor Compound. Duan, Y; Lin, W; Ou, C; Wang, X; Wu, G; Xu, Z; Yan, Y; Zeng, S; Zhou, J; Zhou, Y, 2020)	2.72
"Sulforaphane is an isothiocyanate compound that has been derived from cruciferous vegetables. "	( Sulforaphane as an anticancer molecule: mechanisms of action, synergistic effects, enhancement of drug safety, and delivery systems. Akter, S; Kamal, MM; Lin, CN; Nazzal, S, 2020)	3.44
"Sulforaphane (SF) is an antioxidant known to protect against MA-induced AKI."	( Altered proximal tubule fatty acid utilization, mitophagy, fission and supercomplexes arrangement in experimental Fanconi syndrome are ameliorated by sulforaphane-induced mitochondrial biogenesis. Briones-Herrera, A; Pedraza-Chaverri, J; Ramírez-Camacho, I; Tapia, E; Zazueta, C, 2020)	1.48
"Sulforaphane (SFN) is an organic isothiocyanate found in cruciferous plants."	( Sulforaphane protects against skeletal muscle dysfunction in spontaneous type 2 diabetic db/db mice. Chen, J; Liao, Z; Lu, A; Pu, D; Sun, Y; Wang, M; Xiao, Q; Zhao, Y; Zhu, S, 2020)	2.72
"Sulforaphane (SFN) is an isothiocyanate derived from broccoli that is currently under evaluation in multiple clinical trials for prevention of several diseases, including cancer."	( Sulforaphane Diminishes the Formation of Mammary Tumors in Rats Exposed to 17β-Estradiol. Chartoumpekis, DV; Fazzari, M; Kensler, TW; Liao, Y; Michalopoulos, GK; Oesterreich, S; Palliyaguru, DL; Skoko, JJ; Wendell, SG; Yang, L, 2020)	2.72
"Sulforaphane (SFN) is a compound derived from cruciferous plants shown to be effective in cancer prevention and suppression. "	( Co-administration of sulforaphane and doxorubicin attenuates breast cancer growth by preventing the accumulation of myeloid-derived suppressor cells. Chen, H; Huang, L; Liu, S; Rong, Y; Song, X; Wang, F; Yi, K; Yuan, C; Zhang, W, 2020)	2.32
"Sulforaphane (SFN) is a natural product and acts as a neuroprotective agent to suppress inflammatory response in brain."	( Sulforaphane mitigates LPS-induced neuroinflammation through modulation of Cezanne/NF-κB signalling. Chen, LW; Chen, Q; Wang, J; Wang, ZC; Yu, LS, 2020)	2.72
"Sulforaphane is a natural compound that presents anti-inflammatory and antioxidant properties, including in the central nervous system (CNS). "	( Sulforaphane Induces Glioprotection After LPS Challenge. Belló-Klein, A; Bobermin, LD; Dos Santos, TM; Gonçalves, CA; Quincozes-Santos, A; Weber, FB; Wyse, ATS, 2022)	3.61
"Sulforaphane (SFN) is a derivative of a glucosinolate, which is abundant in cruciferous vegetables, and can pass through the placental barrier."	( Nano-sulforaphane attenuates PhIP-induced early abnormal embryonic neuro-development. Bao, Y; Brand-Saberi, B; Cheng, X; Li, T; Liu, C; Liu, X; Qi, S; Sindi, M; Wang, G; Yan, Y; Yang, W; Yang, X; Zhang, P, 2021)	1.86
"Sulforaphane (SFN) is an isothiocyanate compound found in cruciferous vegetables."	( Sulforaphane suppresses polyinosinic‑polycytidylic acid‑stimulated release of cytokines, chemokines and MMPs by human corneal fibroblasts. Chen, L; Liu, P; Liu, Y; Yang, X; Zhao, X; Zheng, H; Zheng, X, 2020)	2.72
"Sulforaphane (SFN) is a phytocompound belonging to the isothiocyanate family. "	( Efficacy of Sulforaphane in Neurodegenerative Diseases. Bramanti, P; Mazzon, E; Schepici, G, 2020)	2.38
"l-Sulforaphane (SFN) is an isothiocyanate in cruciferous vegetables of the brassica class that has potent protective effects against oxidative stress."	( Effect of sulforaphane on apoptosis, reactive oxygen species and lipids peroxidation of human sperm during cryopreservation. Amidi, F; Esfandyari, S; Khosravizadeh, Z; Mahdavinezhad, F; Nashtaei, MS; Nekoonam, S; Valipour, J, 2021)	1.58
"Sulforaphane (SFN) is an isothiocyanate compound present in cruciferous vegetables. "	( Anti-inflammatory effect of sulforaphane on LPS-stimulated RAW 264.7 cells and ob/ob mice. Dissanayake, CY; Han, CH; Lee, YJ; Natraj, P; Ranaweera, SS, 2020)	2.29
"Sulforaphane (SFN) is a sulfur-containing isothiocyanate found in cruciferous vegetables (Brassicaceae) and a well-known activator of nuclear factor-erythroid 2-related factor 2 (Nrf2), considered a master regulator of cellular antioxidant responses. "	( Cruciferous vegetables: rationale for exploring potential salutary effects of sulforaphane-rich foods in patients with chronic kidney disease. Alvarenga, LA; Cardozo, LFMF; Dai, L; Lindholm, B; Mafra, D; Ribeiro, M; Shiels, PG; Stenvinkel, P, 2021)	2.29
"Sulforaphane (SFN) is an isothiocyanate found mainly in cruciferous vegetables and exerts antioxidant and anti-inflammatory effects in mammalian cells."	( The Isothiocyanate Sulforaphane Depends on the Nrf2/γ-GCL/GSH Axis to Prevent Mitochondrial Dysfunction in Cells Exposed to Methylglyoxal. Brasil, FB; de Almeida, FJS; de Oliveira, MR; Dos Santos Petry, F; Gobbo, RCB; Luckachaki, MD, 2021)	1.67
"Sulforaphane (SFN) is a potent anti-cancer isothiocyanate originating from"	( Metabolism, absorption, and anti-cancer effects of sulforaphane: an update. Du, M; Gu, HF; Mao, XY, 2022)	1.69
"Sulforaphane (SFN) is a naturally occurring organosulfur compound found in cruciferous vegetables such as broccoli, brussels sprouts and cabbage. "	( Sulforaphane-cisplatin combination inhibits the stemness and metastatic potential of TNBCs via down regulation of sirtuins-mediated EMT signaling axis. Sharma, A; Sharma, S; Shrivastava, N; Sinha, S; Vora, J, 2021)	3.51
"Sulforaphane (SFN) is a phytochemical compound extracted from cruciferous plants, like broccoli or cauliflower. "	( Sulforaphane exposure impairs contractility and mitochondrial function in three-dimensional engineered heart tissue. Brandt, T; Cuello, F; Eschenhagen, T; Friedrich, FW; Hansen, A; Klampe, B; Lorenz, K; Meisterknecht, J; Piasecki, A; Raabe, J; Rhoden, A; Schweizer, M; Uebeler, J; Ulmer, BM; Wittig, I, 2021)	3.51
"Sulforaphane is a phytochemical that is commonly found in broccoli and broccoli sprouts. "	( Oral chronic sulforaphane effects on heavy resistance exercise: Implications for inflammatory and muscle damage parameters in young practitioners. Kihara, H; Kumazawa, Y; Sato, K; Tatara, K, 2021)	2.43
"Sulforaphane is a type of organosulfur compound known as an isothiocyanate."	( Sulforaphane enhances long-term potentiation and ameliorate scopolamine-induced memory impairment. Choi, GW; Choi, GY; Hwang, ES; Hwang, Y; Kim, BI; Kim, HB; Maeng, S; Park, H; Park, HS; Park, JH; Park, KS; Sul, JY, 2021)	2.79
"Sulforaphane (SFN) is a natural glucosinolate found in cruciferous vegetables that acts as a chemopreventive agent, but its mechanism of action is not clear. "	( Sulforaphane Impact on Reactive Oxygen Species (ROS) in Bladder Carcinoma. Blaheta, RA; Chun, FK; Rutz, J; Xie, H, 2021)	3.51
"Sulforaphane (SFN) is an organic isothiocyanate and an NF-E2-related factor-2 (Nrf2) inducer that exerts prophylactic effects on depression-like behavior in mice. "	( Sulforaphane activates anti-inflammatory microglia, modulating stress resilience associated with BDNF transcription. Cao, QQ; Chen, G; Du, PF; Fu, R; He, LJ; Hu, SW; Qi, Q; Sun, YR; Tang, R; Xiao, F; Zhang, JC, 2022)	3.61
"Sulforaphane is a small molecule isothiocyanate which exhibits anticancer potential, yet its biological targets remain poorly understood. "	( Competition-based, quantitative chemical proteomics in breast cancer cells identifies new target profiles for sulforaphane. Clulow, JA; Jones, LH; Kalesh, KA; Lanyon-Hogg, T; Storck, EM; Tate, EW, 2017)	2.11
"Sulforaphane (SFN) is an antioxidant agent, which exerts protective effects against cell damage by activating the nuclear factor erythroid 2 like 2 (NFE2L2; Nrf2)."	( Sulforaphane increases Nrf2 expression and protects alveolar epithelial cells against injury caused by cigarette smoke extract. Chang, J; Cui, H; Guo, D; Jiao, Z; Li, J; Nie, D, 2017)	2.62
"Sulforaphane (SFN) is an isothiocyanate compound derived from glucoraphanin, which is found in cruciferous vegetables, and has been heralded as a chemopreventive and/or chemotherapeutic agent. "	( Pro-oxidant activity of sulforaphane and cisplatin potentiates apoptosis and simultaneously promotes autophagy in malignant mesothelioma cells. Lee, SH; Lee, YJ, 2017)	2.2
"Sulforaphane (SFN) is a dietary isothiocyanate abundantly available in cruciferous vegetables and has been shown to possess anti-inflammatory and immunomodulatory activities. "	( Sulforaphane inhibits the interferon-γ-induced expression of MIG, IP-10 and I-TAC in INS‑1 pancreatic β-cells through the downregulation of IRF-1, STAT-1 and PKB. Jang, BC; Kim, S; Park, JW; Park, YK; Ramalingam, M, 2017)	3.34
"Sulforaphane is a naturally occurring antioxidant."	( Stable sulforaphane protects against gait anomalies and modifies bone microarchitecture in the spontaneous STR/Ort model of osteoarthritis. Aljazzar, A; Chan, B; Chang, YM; de Souza, R; Hopkinson, M; Javaheri, B; Lee, PD; Orriss, IR; Piles, M; Pitsillides, AA; Pollard, A; Poulet, B; Shervill, E, 2017)	1.63
"Sulforaphane is a diet-derived cancer prevention agent that is effective in suppressing tumor growth in animal models of skin cancer."	( Combination cisplatin and sulforaphane treatment reduces proliferation, invasion, and tumor formation in epidermal squamous cell carcinoma. Adhikary, G; Eckert, RL; George, N; Grun, D; Kerr, C, 2018)	1.5
"Sulforaphane is a compound with high antioxidant properties. "	( The effect of sulforaphane on oxidative stress and inflammation in rats with toxic hepatitis induced by acetaminophene. Aktas, MS; Dokumacioglu, A; Dokumacioglu, E; Hanedan, B; Iskender, H; Musmul, A; Sen, TM, 2017)	2.26
"Sulforaphane is a protective agent against acetaminophen-induced liver damage and it can be added in the treatment protocol (Tab. "	( The effect of sulforaphane on oxidative stress and inflammation in rats with toxic hepatitis induced by acetaminophene. Aktas, MS; Dokumacioglu, A; Dokumacioglu, E; Hanedan, B; Iskender, H; Musmul, A; Sen, TM, 2017)	2.26
"Sulforaphane (SFN) is a natural compound of many diets and is now being used in clinical trials for other pathologies."	( Nrf2-Inducers Counteract Neurodegeneration in Frataxin-Silenced Motor Neurons: Disclosing New Therapeutic Targets for Friedreich's Ataxia. Bertini, E; Carrozzo, R; Pastore, A; Petrillo, S; Piemonte, F; Piermarini, E; Schirinzi, T; Vasco, G, 2017)	1.18
"Sulforaphane (SFN) is an isothiocyanate derived from cruciferous vegetables. "	( Sulforaphane restores acetyl-histone H3 binding to Bcl-2 promoter and prevents apoptosis in ethanol-exposed neural crest cells and mouse embryos. Cai, L; Chen, SY; Chen, X; Feng, W; Liu, J; Wu, X; Yuan, F, 2018)	3.37
"Sulforaphane is a naturally available phytochemical with antioxidant, anti-inflammatory, and anticarcinogenic properties."	( Assessment of sulforaphane-induced protective mechanisms against cadmium toxicity in human mesenchymal stem cells. Alkharashi, NAO; Alshatwi, AA; Athinarayanan, J; Periasamy, VS, 2018)	1.56
"Sulforaphane is a phytochemical that is usually found in cruciferous vegetables and is known to have a depressive effect on gastric cancer. "	( Storage in high-barrier pouches increases the sulforaphane concentration in broccoli florets. Akihiro, T; Makino, Y; Mizosoe, T; Nishimura, Y; Oshita, S, 2018)	2.18
"Sulforaphane (SF) is an indirect antioxidant that shows nephroprotective effects."	( Sulforaphane prevents maleic acid-induced nephropathy by modulating renal hemodynamics, mitochondrial bioenergetics and oxidative stress. Aparicio-Trejo, OE; Avila-Rojas, SH; Briones-Herrera, A; Cristóbal, M; Hernández-Pando, R; León-Contreras, JC; Pedraza-Chaverri, J; Pinzón, E; Sánchez-Lozada, LG; Tapia, E, 2018)	2.64
"Sulforaphane (SFN) is a pharmacological activator of Nrf2 that provokes Nrf2-mediated intracellular defenses, including antioxidant and anti-inflammatory responses, under oxidative stress (OS) conditions."	( Protective Effects of Sulforaphane on Cognitive Impairments and AD-like Lesions in Diabetic Mice are Associated with the Upregulation of Nrf2 Transcription Activity. Chen, J; Luo, C; Lv, A; Pu, D; Sun, Y; Xiao, Q; Zhao, K; Zhao, Y; Zhu, S, 2018)	1.52
"Sulforaphane (SFN) is a natural compound that has been suggested as an antioxidant."	( Sulforaphane Modulates Joint Inflammation in a Murine Model of Complete Freund's Adjuvant-Induced Mono-Arthritis. Abreu-Silva, AL; da Penha, TA; de Aquino, AF; de Sá, JC; de Souza, BGGF; Fialho Sousa, NC; França Muniz, T; Grisotto, MAG; Nascimento da Silva, LC; Neuza da Silva Nina, L; Silva E Silva, C; Silva Rodrigues, JF; Soares Fernandes, E, 2018)	2.64
"Sulforaphane is an herbal isothiocyanate enriched in cruciferous vegetables. "	( Sulforaphane Upregulates the Heat Shock Protein Co-Chaperone CHIP and Clears Amyloid-β and Tau in a Mouse Model of Alzheimer's Disease. Choi, BR; Han, JS; Kim, J; LaFerla, FM; Lee, KW; Lee, S; Park, JHY, 2018)	3.37
"Sulforaphane (SFN) is a dietary component with multiple bioactivities; however, its role in obesity-related metabolic derangement remains unclear. "	( Sulforaphane ameliorates glucose intolerance in obese mice via the upregulation of the insulin signaling pathway. Chen, JH; Fu, JF; Han, LY; Hua, QH; Shan, YJ; Xu, Y; Zhang, XH; Zhang, ZW; Zhao, JS; Zou, ZQ, 2018)	3.37
"Sulforaphane (SFN) is a naturally occurring isothiocyanate derived from the precursor glucosinolate, glucoraphanin (GFN), which is found in cruciferous vegetables such as broccoli."	( Sulforaphane absorption and histone deacetylase activity following single dosing of broccoli sprout supplement in normal dogs. Beaver, LM; Bracha, S; Curran, KM; Ho, E; Stevens, JF; Wong, CP, 2018)	2.64
"Sulforaphane is an isothiocyanate, which is found in cruciferous vegetables."	( Antitumor activity of sulforaphane in mice model of skin cancer via blocking sulfatase-2. Alyoussef, A; Taha, M, 2019)	1.55
"Sulforaphane is an isothiocyanate occurring in stored form as glucoraphanin in cruciferous vegetables such as cabbage, cauliflower, and kale, and at high levels in broccoli especially in broccoli sprouts. "	( Isothiocyanate from Broccoli, Sulforaphane, and Its Properties. Anzenbacher, P; Anzenbacherova, E; Vanduchova, A, 2019)	2.25
"Sulforaphane (SFN) is a naturally occurring isothiocyanate derived from cruciferous vegetables such as broccoli. "	( Sulforaphane as anticancer agent: A double-edged sword? Tricky balance between effects on tumor cells and immune cells. Hänsch, GM; Hübner, K; Liang, J; Samstag, Y, 2019)	3.4
"Sulforaphane (SFN) is a phytochemical antioxidant known to affect multiple cellular targets including Nrf2-ARE pathway in chemoprevention."	( Sulforaphane enriched transcriptome of lung mitochondrial energy metabolism and provided pulmonary injury protection via Nrf2 in mice. Bell, DA; Blankenship-Paris, T; Cho, HY; Deterding, L; Kleeberger, SR; Lih, F; Miller-DeGraff, L; Morgan, DL; Panduri, V; Reddy, AJ; Talalay, P; Wang, X; Yamamoto, M, 2019)	2.68
"Sulforaphane is a redox-active natural product present in cruciferous vegetables like broccoli. "	( Broccoli sprout beverage is safe for thyroid hormonal and autoimmune status: Results of a 12-week randomized trial. Chartoumpekis, DV; Chen, JG; Groopman, JD; Kensler, TW; Sykiotis, GP; Ziros, PG, 2019)	1.96
"Sulforaphane (SFN) is an isothiocyanate isolated from Brassica plants that has been shown to modulate many critical factors inside the cells helping to counteract aging processes."	( Sulforaphane Cannot Protect Human Fibroblasts From Repeated, Short and Sublethal Treatments with Hydrogen Peroxide. Astori, E; Ciusani, E; Coccé, V; Colombo, G; Costantini, G; Dalle-Donne, I; Fumagalli, MR; La Porta, CAM; Lionetti, MC; Miani, A; Milzani, A; Mutti, F; Soldati, E, 2019)	2.68
"Sulforaphane is a Nrf2 activator but is unstable at ambient temperature."	( SFX-01 reduces residual disability after experimental autoimmune encephalomyelitis. Copple, IM; Franklin, S; Galea, I; Howat, DW, 2019)	1.24
"Sulforaphane (SFN) is an active component extracted from vegetables like cauliflower and broccoli. "	( Effects of sulforaphane in the central nervous system. Chen, D; Chen, Z; Huang, C; Jin, J; Wu, J; Wu, Y, 2019)	2.35
"Sulforaphane is a new and effective anti-cancer component that is abundant in broccoli. "	( Transcriptome reveals the gene expression patterns of sulforaphane metabolism in broccoli florets. Fang, Z; Li, L; Li, Z; Liu, Y; Lv, H; Yang, L; Zhang, Y; Zhuang, M, 2019)	2.21
"Sulforaphane is a dietary compound possessing anti-inflammatory, antioxidant, anti-diabetic, anti-carcinogenic, and anti-aging properties. "	( Sulforaphane alleviates cadmium-induced toxicity in human mesenchymal stem cells through POR and TNFSF10 genes expression. Alkharashi, NAO; Alshatwi, AA; Athinarayanan, J; Periasamy, VS, 2019)	3.4
"Sulforaphane is an active compound produced after conversion of glucoraphanin by the myrosinase enzyme in broccoli ("	( Sulforaphane-Enriched Broccoli Sprouts Pretreated by Pulsed Electric Fields Reduces Neuroinflammation and Ameliorates Scopolamine-Induced Amnesia in Mouse Brain through Its Antioxidant Ability via Nrf2-HO-1 Activation. Cho, K; Choi, HJ; Kim, SY; Park, YU; Subedi, L, 2019)	2.68
"Sulforaphane is a natural isothiocyanate available from cruciferous vegetables with multiple characteristics including antioxidant, antitumor and anti-inflammatory effect. "	( Comparative transcriptome analyses of genes involved in sulforaphane metabolism at different treatment in Chinese kale using full-length transcriptome sequencing. Huang, K; Liang, M; Liu, M; Mao, S; Wang, J; Wu, Q; Xu, H; Yuan, Y, 2019)	2.2
"Sulforaphane (SFN) is a member of the isothiocyanate family that has anti-inflammatory action as well as anti-carcinogenic properties. "	( Sulforaphane-PLGA microspheres for the intra-articular treatment of osteoarthritis. Choi, YJ; Im, GI; Jeong, GJ; Ko, JY, 2013)	3.28
"Sulforaphane (SFN) is a natural compound that has been investigated as a chemopreventive agent. "	( Stability of sulforaphane for topical formulation. Bowden, GT; Dickinson, SE; Franklin, SJ; Karlage, KL; Myrdal, PB, 2014)	2.21
"Sulforaphane (SFN) is a potent inducer of detoxication enzymes such as NAD(P)H:quinone oxidoreductase 1 (NQO1) and glutathione-S-transferase (GST) via the Kelch-like erythroid-derived protein with CNC homology-associated protein 1 (Keap1)-NF-E2-related factor 2 (Nrf2) signaling pathway. "	( Reduced formation of depurinating estrogen-DNA adducts by sulforaphane or KEAP1 disruption in human mammary epithelial MCF-10A cells. Cavalieri, EL; Davidson, NE; Groopman, JD; Kensler, TW; Liao, Y; Rogan, EG; Visvanathan, K; Yager, JD; Yang, L; Zahid, M, 2013)	2.08
"Sulforaphane (SF) is a natural isothiocyanate in broccoli sprouts with cancer chemopreventive activity. "	( Kinetics of sulforaphane in mice after consumption of sulforaphane-enriched broccoli sprout preparation. Li, X; Li, Y; Schwartz, SJ; Sun, D; Zhang, T; Zou, P, 2013)	2.21
"Sulforaphane is a naturally occuring antioxidative and anti-inflammatory isothiocyanat. "	( Sulforaphane decreases kidney injury after transplantation in rats: role of mitochondrial damage. Bruns, H; Cekauskas, A; Gross, ML; Herr, I; Jankevicius, F; Manikas, M; Schemmer, P; Strupas, K; Zorn, M, 2013)	3.28
"Sulforaphane proved to be an effective in vivo inhibitor of acute ethanol-induced fatty liver in mice."	( Sulforaphane induces Nrf2 and protects against CYP2E1-dependent binge alcohol-induced liver steatosis. Lin, J; Wu, D; Zhou, R, 2014)	3.29
"D,L-Sulforaphane (SFN) is a promising chemopreventive agent with in vivo efficacy against prostate cancer in experimental rodents. "	( Functional relevance of D,L-sulforaphane-mediated induction of vimentin and plasminogen activator inhibitor-1 in human prostate cancer cells. Singh, SV; Vyas, AR, 2014)	1.25
"Sulforaphane (SFN) is an isothiocyanate found in cruciferous vegetables."	( Sulforaphane as a promising molecule for fighting cancer. Fimognari, C; Hrelia, P; Lenzi, M, 2014)	2.57
"Sulforaphane (SFN) is an excellent antioxidant agent, few of the studies focus on the possible protective role of SFN from cigarette smoke-induced injury on alveolar epithelial cells."	( A protective role of sulforaphane on alveolar epithelial cells exposed to cigarette smoke extract. Chang, J; Jiao, Z; Li, M; Liu, F; Nie, D; Wang, C; Wang, Y; Zhang, Q; Zhu, Y, 2013)	2.15
"Sulforaphane (SFN) is an organosulfur compound present in vegetables and has potent anti-oxidant and anti-inflammatory activities. "	( Sulforaphane ameliorates the development of experimental autoimmune encephalomyelitis by antagonizing oxidative stress and Th17-related inflammation in mice. Cui, W; Ge, XL; Guo, L; Li, B; Li, R; Liu, J; Liu, Q; Song, XJ; Wang, Y; Xie, XH; Zhang, J, 2013)	3.28
"Sulforaphane (SF) is a promising isothiocyanate compound occurring in cruciferous plants with reported antiproliferative and proapoptotic activity in several tumor cell lines including melanoma."	( Sulforaphane-induced apoptosis involves p53 and p38 in melanoma cells. Cervinka, M; Rudolf, E; Rudolf, K, 2014)	2.57
"Sulforaphane (SFN) is a naturally-occurring isothiocyanate best known for its role as an indirect antioxidant. "	( Sulforaphane induces oxidative stress and death by p53-independent mechanism: implication of impaired glutathione recycling. Almeida, L; Costa, M; Ferreira de Oliveira, JM; Oliveira, H; Pedrosa, T; Pimentel, F; Pinto, P; Remédios, C; Santos, C, 2014)	3.29
"Sulforaphane is a naturally occurring isothiocyanate in cruciferous vegetables. "	( Off-target effects of sulforaphane include the derepression of long terminal repeats through histone acetylation events. Baier, SR; Schlegel, V; Zbasnik, R; Zempleni, J, 2014)	2.16
"Sulforaphane is a natural chemopreventive isothiocyanate and abundantly found in various cruciferous vegetables. "	( Sulforaphane suppresses LPS-induced or TPA-induced downregulation of PDCD4 in RAW 264.7 cells. Cho, JH; Keum, YS; Kim, YW, 2014)	3.29
"Sulforaphane is a dietary isothiocyanate found in cruciferous vegetables showing antileukemic activity. "	( Antileukemic activity of sulforaphane in primary blasts from patients affected by myelo- and lympho-proliferative disorders and in hypoxic conditions. Calcabrini, C; Cantelli-Forti, G; Carulli, G; Fimognari, C; Fontanelli, G; Hrelia, P; Rousseau, M; Sestili, P; Turrini, E, 2014)	2.15
"Sulforaphane (SFN) is a phytochemical derived from cruciferous vegetables that induces anti-proliferative and pro-apoptotic responses in prostate cancer cells, but not in normal prostate cells."	( Transcriptome analysis reveals a dynamic and differential transcriptional response to sulforaphane in normal and prostate cancer cells and suggests a role for Sp1 in chemoprevention. Beaver, LM; Buchanan, A; Chang, JH; Dashwood, RH; Ho, E; Löhr, CV; Riscoe, AN; Sokolowski, EI; Williams, DE; Wong, CP, 2014)	1.35
"Sulforaphane is a cruciferous vegetable-derived isothiocyanate with promising chemopreventive and therapeutic activities. "	( Sulforaphane down-regulates SKP2 to stabilize p27(KIP1) for inducing antiproliferation in human colon adenocarcinoma cells. Chang, CC; Chi-Hung Or, R; Chung, YK; Lu, CH; Ouyang, WT; Yang, SY, 2015)	3.3
"Sulforaphane (SFP) is a naturally occurring isothiocyanate that has huge health benefits for humans."	( Sulforaphane reverses glucocorticoid-induced apoptosis in osteoblastic cells through regulation of the Nrf2 pathway. Chu, J; Li, G; Lin, H; Niu, Y; Sun, J; Wei, B; Zeng, R; Zheng, J, 2014)	2.57
"Sulforaphane is a natural product found in broccoli, which is known to exert many different molecular effects in the cell, including inhibition of histone deacetylase (HDAC) enzymes. "	( The effect of sulforaphane on histone deacetylase activity in keratinocytes: Differences between in vitro and in vivo analyses. Bec, SL; Bowden, GT; Dickinson, SE; Horn, DJ; Janda, J; Rim, SH; Rusche, JJ; Smith, CL, 2015)	2.22
"Sulforaphane (SFN) is a naturally occurring isothiocynate compound found in cruciferous vegetables. "	( Sulforaphane suppresses cardiac hypertrophy by inhibiting GATA4/GATA6 expression and MAPK signaling pathways. Jeong, MH; Kee, HJ; Kim, GR; Kim, IK, 2015)	3.3
"Sulforaphane is a natural product that is constantly under biological investigation for its unique biological properties. "	( Isothiocyanate synthetic analogs: biological activities, structure-activity relationships and synthetic strategies. Fimognari, C; Milelli, A; Minarini, A; Neviani, P; Ticchi, N; Tumiatti, V, 2014)	1.85
"Sulforaphane (SFN) is a material of isothiocyanate group and known to have anticancer effect."	( Enhancement of cytotoxic effect on human head and neck cancer cells by combination of photodynamic therapy and sulforaphane. Ahn, JC; Chung, PS; Hwang, HJ; Lee, SJ; Shin, JI, 2015)	1.35
"Sulforaphane is a constituent of these foods postulated to harbor the anti-neoplastic activity based on multiple tumor models. "	( A phase II study of sulforaphane-rich broccoli sprout extracts in men with recurrent prostate cancer. Alumkal, JJ; Beer, TM; Cherala, G; Flamiatos, JF; Gao, L; Gibbs, A; Graff, JN; Kleinschmidt, R; Koop, DR; Mori, M; Munar, M; Ryan, CW; Schwartzman, J; Slottke, R; Tucker, E, 2015)	2.18
"Sulforaphane (SFN) is a natural compound that is extracted from cruciferous vegetables and possesses potent anti-inflammatory, antioxidant, and anticancer activities."	( Sulforaphane increases the survival rate in rats with fulminant hepatic failure induced by D-galactosamine and lipopolysaccharide. El-Sayeh, BM; Kenawy, SA; Khalil, WK; Salem, HA; Sayed, RH, 2014)	2.57
"Sulforaphane is a naturally occurring isothiocyanate capable of stimulating cellular antioxidant defenses and inducing phase 2 detoxifying enzymes, which can protect cells against oxidative damage. "	( Modulation of apoptosis by sulforaphane is associated with PGC-1α stimulation and decreased oxidative stress in cardiac myoblasts. Araujo, AS; Baregzay, B; Belló-Klein, A; Bonetto, JH; Brum, IS; de Castro, AL; Fernandes, RO; Forsyth, H; Khaper, N; Llesuy, SF; Puukila, S; Schenkel, PC, 2015)	2.16
"Sulforaphane (SFN) is an isothiocyanate derived from glucoraphanin (GRA), which is found in great amounts especially in broccoli. "	( Clinical and molecular evidence of the consumption of broccoli, glucoraphanin and sulforaphane in humans. Conzatti, A; Fróes, FC; Schweigert Perry, ID; Souza, CG, 2014)	2.07
"Sulforaphane (SFN) is an isothiocyanate present in cruciferous vegetables, which has been shown to exert an anti-cancer effect when tested in vitro and in vivo. "	( Inhibition of autophagy by 3-methyladenine potentiates sulforaphane-induced cell death of BE(2)-C human neuroblastoma cells. Boratyn, E; Durbas, M; Gaik, M; Horwacik, I; Kołoczek, H; Rokita, H; Szczodrak, M; Szychowska, K; Zając, G, 2015)	2.11
"Sulforaphane (SFN) is a molecule within the isothiocyanate (ITC) group of organosulfur compounds. "	( The antioxidant properties of organosulfur compounds (sulforaphane). Binda, NS; Caligiorne, RB; de Figueiredo, SM; Nogueira-Machado, JA; Vieira-Filho, SA, 2015)	2.11
"Sulforaphane (SFN) is a natural isothiocyanate, known to reduce the risk of cancer and also aortic damage and diabetic cardiomyopathy induced by type 2 diabetes, etc. "	( Insights into the binding sites of sulforaphane on insulin studied by electrospray ionization mass spectrometry. Nagaveni, V; Prabhakar, S, 2015)	2.14
"Sulforaphane (SFN), which is an isothiocyanate (ITC) that is found in cruciferous vegetables, has received considerable attention because of its beneficial effects. "	( Sulforaphane protected the injury of human vascular endothelial cell induced by LPC through up-regulating endogenous antioxidants and phase II enzymes. Ding, Z; He, C; Li, B; Liu, X; Shan, Y; Tian, S, 2015)	3.3
"Sulforaphane (SFN) is an isothiocyanate found in cruciferous vegetables with anti-inflammatory, anti-oxidant and anti-cancer activities. "	( Interaction of sulforaphane with DNA and RNA. Abassi Joozdani, F; Abassi Joozdani, P; Nafisi, S; Yari, F, 2015)	2.21
"Sulforaphane (SFN) is a natural compound that displays antioxidant and anti-inflammatory activities."	( Sulforaphane rescues memory dysfunction and synaptic and mitochondrial alterations induced by brain iron accumulation. Aguzzoli, C; Bogo, MR; Dargél, VA; de Freitas, BS; de Lima, MN; Falavigna, L; Florian, PZ; Kist, LW; Köbe, LM; Lavich, IC; Piffero, B; Schröder, N, 2015)	2.58
"Sulforaphane (SFN) is a chemoprotective compound derived from cruciferous vegetables which can up-regulate antioxidant enzymes and induce apoptosis and autophagy."	( Sulforaphane Protects the Liver against CdSe Quantum Dot-Induced Cytotoxicity. Bao, Y; Chao, Y; Hamilton, CJ; He, Y; Li, B; Liu, R; Roberts, AA; Sexton, DW; Shan, Y; Wang, W; Wileman, T; Yu, G, 2015)	2.58
"Sulforaphane (SFN) is an ITC shown to possess anticancer activities by both in vivo and epidemiological studies."	( Sulforaphane Protects against Cardiovascular Disease via Nrf2 Activation. Bai, Y; Cui, J; Ma, C; Wang, X; Zhao, S; Zheng, Y, 2015)	2.58
"Sulforaphane (SFN) is a natural compound with antioxidative, anti-inflammatory and neuroprotective activities."	( Sulforaphane produces antidepressant- and anxiolytic-like effects in adult mice. Gao, Q; Gao, Y; Liang, Y; Ma, Y; Shi, H; Wang, X; Wu, S; Xi, Y; Zhao, P, 2016)	2.6
"Sulforaphane is a phytochemical that has received attention in recent years due to its chemopreventive properties. "	( Microencapsulation of sulforaphane from broccoli seed extracts by gelatin/gum arabic and gelatin/pectin complexes. Campas-Baypoli, ON; Cantú-Soto, EU; García-Saldaña, JS; López-Cervantes, J; Rodríguez-Ramírez, R; Sánchez-Machado, DI, 2016)	2.19
"Sulforaphane (SFN) is an antioxidant phytocompound that acts against cellular oxidative stress and tumorigenesis."	( Sulforaphane Suppresses Hepatitis C Virus Replication by Up-Regulating Heme Oxygenase-1 Expression through PI3K/Nrf2 Pathway. Chen, WC; Chen, YH; Hsu, YC; Lee, JC; Lin, CK; Tseng, CK; Yu, JS, 2016)	2.6
"Sulforaphane (SFN) is an isothiocyanate, inducing cytotoxic effects in various human cancer cells, including leukemia cells through cell cycle arrest and apoptosis. "	( Sulforaphane promotes immune responses in a WEHI‑3‑induced leukemia mouse model through enhanced phagocytosis of macrophages and natural killer cell activities in vivo. Chen, YL; Chung, JG; Hsueh, SC; Lee, CH; Liao, NC; Lu, HF; Shih, YL; Wu, LY, 2016)	3.32
"Sulforaphane appears to be a promising compound with neuroprotective properties that may play an important role in preventing PD."	( Sulforaphane protects against rotenone-induced neurotoxicity in vivo: Involvement of the mTOR, Nrf2, and autophagy pathways. Cai, X; Cao, P; Chen, B; Chen, J; Cheng, X; Hu, Z; Lu, W; Shen, J; Sun, X; Wang, X; Wu, L; Yan, H; Yang, J; Yang, Y; Ye, J; Zhou, Q, 2016)	2.6
"Sulforaphane (SFN) is a natural, compound-based drug derived from dietary isothiocyanates which has previously been shown to possess potent anti-tumor and chemopreventive effects against several types of cancer."	( Sulforaphane, a Dietary Isothiocyanate, Induces G₂/M Arrest in Cervical Cancer Cells through CyclinB1 Downregulation and GADD45β/CDC2 Association. Cheng, YM; Hsu, YC; Tsai, CC, 2016)	2.6
"Sulforaphane (SFN) is a natural and highly effective antioxidant. "	( Sulforaphane Prevents Testicular Damage in Kunming Mice Exposed to Cadmium via Activation of Nrf2/ARE Signaling Pathways. Gao, F; Guo, Y; He, JB; Li, L; Li, P; Liu, MD; Long, M; Yang, SH; Yu, LH; Zhang, Y, 2016)	3.32
"Sulforaphane (SFN) is a naturally occurring chemopreventive agent, which effectively inhibits proliferation of HepG2 human hepatocellular carcinoma cells via mitochondria‑mediated apoptosis. "	( Endoplasmic reticulum stress mediates sulforaphane-induced apoptosis of HepG2 human hepatocellular carcinoma cells. Fang, Y; Ji, Y; Qu, Z; Shi, X; Zou, X, 2017)	2.17
"Sulforaphane (SFN) is a thiol compound found in wide abundance in cruciferous plants that has numerous reported therapeutic efficacies."	( Sulforaphane protects against sodium valproate-induced acute liver injury. Atef, H; El-Khouly, OA; Nazmy, EA; Said, E, 2017)	2.62
"Sulforaphane (SFN) is a potent stimulator of the antioxidant nuclear factor erythroid 2-related factor 2 (Nrf-2) system and a suppressor of inflammation."	( Bactericidal antibiotics promote oxidative damage and programmed cell death in sinonasal epithelial cells. Kohanski, MA; Lane, AP; London, NR; Ramanathan, M; Tharakan, A, 2017)	1.18
"Sulforaphane (SFN) is a natural organosulfur compound with anti-oxidant and anti-inflammation properties. "	( Effects of sulforaphane on neural stem cell proliferation and differentiation. Han, Z; Li, C; Xu, Q; Zhao, H, 2017)	2.29
"Sulforaphane (SFN) is a naturally occurring isothiocyanate found in cruciferous vegetables, such as broccoli and cabbage."	( Sulforaphane improves outcomes and slows cerebral ischemic/reperfusion injury via inhibition of NLRP3 inflammasome activation in rats. He, Q; Hou, YH; Li, LY; Song, FZ; Yu, C; Zheng, J, 2017)	2.62
"Sulforaphane is an activator of transcription factor NF-E2-related factor-2 (nrf2) that regulates gene expression through the promoter antioxidant response element (ARE). "	( Activation of NF-E2-related factor-2 reverses biochemical dysfunction of endothelial cells induced by hyperglycemia linked to vascular disease. Adaikalakoteswari, A; Babaei-Jadidi, R; Qian, Q; Rabbani, N; Thornalley, PJ; Xue, M, 2008)	1.79
"Sulforaphane (SFN) is a natural isothiocyanate that is present in cruciferous vegetables such as broccoli and cabbage. "	( Sulforaphane suppressed LPS-induced inflammation in mouse peritoneal macrophages through Nrf2 dependent pathway. Khor, TO; Kong, AN; Lin, W; Wang, H; Wu, RT; Wu, T, 2008)	3.23
"(R)L-sulforaphane (SF) is a compound that protects against erythema, but it can also induce DNA fragmentation that leads to cell death by apoptosis."	( Effect of (R)L-sulforaphane on 5-aminolevulinic acid-mediated photodynamic therapy. Juzeniene, A; Mikolajewska, P; Moan, J, 2008)	1.15
"Sulforaphane (SFN) is a biologically active compound extracted from cruciferous vegetables, and possessing potent anti-cancer and anti-inflammatory activities. "	( Sulforaphane suppresses TNF-alpha-mediated activation of NF-kappaB and induces apoptosis through activation of reactive oxygen species-dependent caspase-3. Choi, YH; Kang, SH; Kim, GY; Kim, MO; Moon, DO, 2009)	3.24
"Sulforaphane (SUL) is an isothiocyanate naturally present in widely consumed vegetables, particularly in broccoli. "	( Sulforaphane stimulates activation of proapoptotic protein bax leading to apoptosis of endothelial progenitor cells. Kitayama, J; Nagawa, H; Nishikawa, T; Okaji, Y; Shuno, Y; Takahashi, K; Tanaka, J; Tsuchiya, T; Tsuno, NH; Yamada, J; Yoneyama, S, 2009)	3.24
"Sulforaphane (SFN) is an indirect antioxidant that protects animal tissues from chemical or biological insults by stimulating the expression of several NF-E2-related factor-2 (Nrf2)-regulated phase 2 enzymes. "	( Sulforaphane protects against cytokine- and streptozotocin-induced beta-cell damage by suppressing the NF-kappaB pathway. Kim, EK; Kim, HJ; Kwon, KB; Moon, WS; Park, BH; Park, JW; Park, R; So, HS; Song, MY, 2009)	3.24
"Sulforaphane is an isothiocyanate derived from cruciferous vegetables, and it has gained attention mainly as a potential chemopreventive agent in part through the induction of detoxifying enzymes."	( Modulation of phase II enzymes by sulforaphane: implications for its cardioprotective potential. Angelini, S; Angeloni, C; Hrelia, P; Hrelia, S; Leoncini, E; Malaguti, M, 2009)	1.35
"Sulforaphane is an isothiocyanate which has antimicrobial and anticarcinogenic properties, this compound is found in a wide variety of plants from genus Brassica oleracea, being the most important broccoli and cabbage."	( [Sulforaphane (1-isothiocyanato-4-(methylsulfinyl)-butane) content in cruciferous vegetables]. Bueno-Solano, C; Camacho-Gil, F; Campas-Baypoli, ON; Lóez-Cervantes, J; Martínez-Ibarra, DM; Rodríguez-Núñez, JR; Sánchez-Machado, DI; Villa-Lerma, AG, 2009)	1.98
"Sulforaphane is known to be an indirect antioxidant that acts by inducing NF-E2-related factor 2 (Nrf2)-dependent phase II enzymes. "	( Protective effect of sulforaphane on indomethacin-induced cytotoxicity via heme oxygenase-1 expression in human intestinal Int 407 cells. Chiu, HF; Yeh, CT; Yen, GC, 2009)	2.11
"Sulforaphane is an isothiocyanate derived from cruciferous vegetables that has been linked to decreased risk of certain cancers. "	( Inhibition of activator protein-1 by sulforaphane involves interaction with cysteine in the cFos DNA-binding domain: implications for chemoprevention of UVB-induced skin cancer. Bowden, GT; Dickinson, SE; Melton, TF; Olson, ER; Saboda, K; Zhang, J, 2009)	2.07
"Sulforaphane (SFN) is an isothiocyanate produced by the enzymatic action of myrosinase on glucorophanin, a glucosinolate contained in cruciferous vegetables."	( Sulforaphane protects against cisplatin-induced nephrotoxicity. Calderón-Oliver, M; Franco, M; Guerrero-Beltrán, CE; Martínez-Martínez, CM; Medina-Campos, ON; Ortiz-Vega, KM; Pedraza-Chaverri, J; Sánchez-González, DJ; Tapia, E, 2010)	2.52
"Sulforaphane is known to be an indirect antioxidant that acts by inducing Nrf2-dependent phase 2 enzymes."	( Sulforaphane protects ischemic injury of hearts through antioxidant pathway and mitochondrial K(ATP) channels. Chae, HJ; Chae, SW; Gao, S; Kim, DS; Kim, SH; Lee, GH; Park, BH; Piao, CS, 2010)	2.52
"Sulforaphane is a compound widely present in consumed vegetables, particularly broccoli. "	( Sulforaphane inhibited melanin synthesis by regulating tyrosinase gene expression in B16 mouse melanoma cells. Kamada, M; Liu, MC; Matsui, T; Sakakibara, Y; Shirasugi, I; Suiko, M, 2010)	3.25
"Sulforaphane (SFN) is a naturally occurring isothiocyanate present in cruciferous vegetables that has antioxidant and anti-inflammatory effects."	( Sulforaphane inhibits endothelial lipase expression through NF-κB in endothelial cells. Jyrkkänen, HK; Kansanen, E; Kivelä, AM; Leinonen, H; Levonen, AL; Mäkinen, PI; Mella-Aho, E; Verma, IM; Xia, Y; Ylä-Herttuala, S, 2010)	2.52
"Sulforaphane (SF) is a well-known chemopreventive phytochemical and occurs in broccoli and to a lesser extent in other cruciferous vegetables, whereas 4-aminobiphenyl (ABP) is a major human bladder carcinogen and is present at significant levels in tobacco smoke. "	( Sulforaphane inhibits 4-aminobiphenyl-induced DNA damage in bladder cells and tissues. Argoti, D; Chen, L; Ding, Y; Paonessa, JD; Randall, KL; Vouros, P; Zhang, Y, 2010)	3.25
"Sulforaphane (SFN) is an isothiocyanate that is naturally present in cruciferous vegetables, with high concentration in broccoli. "	( [Sulforaphane--a possible agent in prevention and therapy of cancer]. Olejnik, A; Tomczyk, J, 2010)	2.71
"Sulforaphane (SF) is a chemopreventive isothiocyanate (ITC) derived from the myrosinase-catalyzed hydrolysis of glucoraphanin, a thioglucoside present in broccoli. "	( Sulforaphane absorption and excretion following ingestion of a semi-purified broccoli powder rich in glucoraphanin and broccoli sprouts in healthy men. Cramer, JM; Jeffery, EH, 2011)	3.25
"Sulforaphane (SFN) is a naturally occurring chemopreventive agent; the induction of cell cycle arrest and apoptosis is a key mechanism by which SFN exerts its colon cancer prevention. "	( Prolonged sulforaphane treatment activates survival signaling in nontumorigenic NCM460 colon cells but apoptotic signaling in tumorigenic HCT116 colon cells. Botnen, JH; Moyer, MP; Trujillo, ON; Zeng, H, 2011)	2.21
"Sulforaphane (SFN) is an isothiocyanate derived from cruciferous vegetables such as broccoli. "	( Differential effects of sulforaphane on histone deacetylases, cell cycle arrest and apoptosis in normal prostate cells versus hyperplastic and cancerous prostate cells. Clarke, JD; Dashwood, RH; Ho, E; Hsu, A; Yu, Z, 2011)	2.12
"Sulforaphane is a predominant isothiocyanate in Brassica oleracea, a family of cruciferous vegetables, and is known to be inversely related to the risk of various types of human carcinomas. "	( Sulforaphane inhibits oral carcinoma cell migration and invasion in vitro. Jee, HG; Kim, JB; Lee, KE; Shin, HK; Youn, YK, 2011)	3.25
"Sulforaphane (SFN) is a natural, biologically active compound extracted from cruciferous vegetables such as broccoli and cabbage with anti-inflammatory and anti-cancer properties. "	( Chemopreventive role of sulforaphane by upholding the GSH redox cycle in pre- and post-initiation phases of experimental lung carcinogenesis. Gayathri, R; Gunassekaran, G; Murugan, S; Priya, DK; Sakthisekaran, D, 2011)	2.12
"Sulforaphane (SFN) is a naturally occurring isothiocyanate found in cruciferous vegetables, such as broccoli, cabbage, cauliflower, etc. "	( Induction of apoptosis by sulforaphane in highly metastatic B16F-10 melanoma cells. Hamsa, TP; Kuttan, G; Thejass, P, 2011)	2.11
"Sulforaphane is an electrophile that can react with protein thiols to form thionoacyl adducts and is believed to affect the Cys residues in Keap1 protein."	( Regulation of the Keap1/Nrf2 system by chemopreventive sulforaphane: implications of posttranslational modifications. Keum, YS, 2011)	1.34
"Sulforaphane (SFN) is a biologically important isothiocyanate found in cruciferous vegetables that is an important candidate chemopreventive agent."	( Sulforaphane suppresses polycomb group protein level via a proteasome-dependent mechanism in skin cancer cells. Balasubramanian, S; Chew, YC; Eckert, RL, 2011)	2.53
"Sulforaphane is a naturally occurring compound found in broccoli and other cruciferous vegetables. "	( Radiosensitization of head and neck cancer cells by the phytochemical agent sulforaphane. Brunner, M; Czembirek, C; Eder-Czembirek, C; Fahim, T; Heiduschka, G; Kotowski, U; Schmidt, R; Thurnher, D, 2011)	2.04
"Sulforaphane is a promising agent in the treatment of head and neck cancer due to its antiproliferative and radio-sensitizing properties. "	( Radiosensitization of head and neck cancer cells by the phytochemical agent sulforaphane. Brunner, M; Czembirek, C; Eder-Czembirek, C; Fahim, T; Heiduschka, G; Kotowski, U; Schmidt, R; Thurnher, D, 2011)	2.04
"Sulforaphane (SF) is a chemopreventive isothiocyanate (ITC) derived from glucoraphanin (GRP) hydrolysis by myrosinase, a thioglucoside present in broccoli. "	( Enhancing sulforaphane absorption and excretion in healthy men through the combined consumption of fresh broccoli sprouts and a glucoraphanin-rich powder. Cramer, JM; Jeffery, EH; Teran-Garcia, M, 2012)	2.22
"Sulforaphane (SF) is a potent antioxidant that protects against dopaminergic cell death."	( Sulforaphane protects SK-N-SH cells against antipsychotic-induced oxidative stress. Bernardo, M; Gassó, P; Lafuente, A; Mas, S; Trias, G, 2012)	2.54
"Sulforaphane (SFN) is a sulfur-containing compound that exhibits anticancer properties, and young sprouts of broccoli are particularly rich in SFN."	( Hydrogen sulfide mediates the anti-survival effect of sulforaphane on human prostate cancer cells. Cao, Q; Pei, Y; Wu, B; Wu, L; Yang, G, 2011)	1.34
"Sulforaphane (SFN) is a naturally occurring compound which is known to induce the phase II antioxidant genes via Nrf2 activation, although the underlying mechanism has not been fully elucidated. "	( Sulforaphane induces antioxidative and antiproliferative responses by generating reactive oxygen species in human bronchial epithelial BEAS-2B cells. Lee, SH; Lee, YJ, 2011)	3.25
"Sulforaphane (SFN) is a dietary isothiocyanate that exerts chemopreventive effects via NF-E2-related factor 2 (Nrf2)-mediated induction of antioxidant/phase II enzymes, such as heme oxygenase-1 (HO-1) and NAD(P)H quinone oxidoreductase 1 (NQO1). "	( Sulforaphane attenuates hepatic fibrosis via NF-E2-related factor 2-mediated inhibition of transforming growth factor-β/Smad signaling. Harris, RA; Kim, HJ; Kim, JY; Lee, IK; Min, AK; Oh, CJ; Park, KG, 2012)	3.26
"Sulforaphane (SFN) is an important cancer preventive agent derived from cruciferous vegetables. "	( Sulforaphane induction of p21(Cip1) cyclin-dependent kinase inhibitor expression requires p53 and Sp1 transcription factors and is p53-dependent. Adhikary, G; Chew, YC; Eckert, RL; Wilson, GM; Xu, W, 2012)	3.26
"Sulforaphane (SFN) is a compound derived from cruciferous plants. "	( Sulforaphane, a cruciferous vegetable-derived isothiocyanate, inhibits protein synthesis in human prostate cancer cells. Herman-Antosiewicz, A; Hofman, D; Konopa, G; Wiczk, A, 2012)	3.26
"Sulforaphane is a promising agent under preclinical evaluation in many models of disease prevention. "	( Keap1-nrf2 signaling: a target for cancer prevention by sulforaphane. Agyeman, AS; Chen, JG; Chen, TY; Egner, PA; Fahey, JW; Groopman, JD; Kensler, TW; Talalay, P; Visvanathan, K, 2013)	2.08
"Sulforaphane is an isothiocyanate well known for its potential health benefits. "	( Quantitative profiling of glucosinolates by LC-MS analysis reveals several cultivars of cabbage and kale as promising sources of sulforaphane. Momose, M; Neyazaki, M; Ogawa, T; Sasaki, K; Shindo, K, 2012)	2.03
"Sulforaphane (SFN) is a compound which is found in cruciferous vegetables and that acts as both a potent antioxidant and regulator of gene expression."	( Metabolic effects of sulforaphane oral treatment in streptozotocin-diabetic rats. de Assis, AM; de Souza, CG; Perry, ML; Rech, A; Sattler, JA; Souza, DO, 2012)	1.42
"Sulforaphane (SF) is an isothiocyanate present in Brassicaceae, vegetables that induce the detoxification of electrophiles and reactive oxygen species. "	( Interactions of sulforaphane and dimethyl sulfoxide with methyl methanesulfonate, urethane, 4-nitroquinoline-1-oxide and hydrogen peroxide in the Drosophila melanogaster wing spot test. Castañeda-Partida, L; Castañeda-Sortibrán, AN; Dueñas-García, IE; Durán-Díaz, A; Heres-Pulido, ME; Ordaz-Téllez, MG; Rodríguez-Arnaiz, R; Sánchez-Santos, A; Santos-Cruz, LF, 2012)	2.17
"Sulforaphane (SFN), is an effective in vitro antagonist of ligand activation of the human pregnane and xenobiotic receptor (PXR). "	( Sulforaphane is not an effective antagonist of the human pregnane X-receptor in vivo. Eaton, DL; Lampe, JW; Levy, L; Poulton, EJ; Shen, DD; Shuhart, MC; Thummel, KE; Tracy, J, 2013)	3.28
"Sulforaphane (SFN) is a dietary cancer preventive with incompletely characterized mechanism(s) of cancer prevention. "	( Sulforaphane inhibits prostaglandin E2 synthesis by suppressing microsomal prostaglandin E synthase 1. Cross, JV; Joplin, DG; Templeton, DJ; Zhou, J, 2012)	3.26
"Sulforaphane (SFN) is a potent chemopreventive agent, which is widely consumed in diet or as a diet supplement. "	( Interactions between drugs and sulforaphane modulate the drug metabolism enzymatic system. Fronczyk, K; Krzysztoń-Russjan, J; Lubelska, K; Milczarek, M; Modzelewska, K; Wiktorska, K, 2012)	2.11
"Sulforaphane is a naturally occurring isothiocyanate, which can be found in cruciferous vegetables such as broccoli and cabbage. "	( A novel antithrombotic effect of sulforaphane via activation of platelet adenylate cyclase: ex vivo and in vivo studies. Chen, WF; Chou, DS; Hsiao, G; Hsieh, CY; Hsu, CY; Jayakumar, T; Lu, WJ; Sheu, JR, 2013)	2.11
"Sulforaphane is a promising chemopreventive agent that exerts its effect by strong induction of phase 2 enzymes via activation of Nrf2."	( Identification of Nrf2-regulated genes induced by the chemopreventive agent sulforaphane by oligonucleotide microarray. Biswal, S; Kensler, TW; Mai, KH; Srisuma, S; Thimmulappa, RK; Yamamoto, M, 2002)	1.27
"Sulforaphane (SFN) is a natural micronutrient found in cruciferous vegetables that has been shown to possess antitumoral properties in carcinogen-treated rats. "	( Mechanism of sulforaphane-induced cell cycle arrest and apoptosis in human colon cancer cells. Cassar, G; Combaret, L; Gamet-Payrastre, L; Li, P; Parnaud, G; Rouimi, P; Tulliez, J, 2004)	2.14
"Sulforaphane (SFN) is a naturally occurring substance of chemopreventive activity."	( Sulforaphane-mediated induction of a phase 2 detoxifying enzyme NAD(P)H:quinone reductase and apoptosis in human lymphoblastoid cells. Kasprzycka-Guttman, T; Kowalska, E; Lubiński, J; Misiewicz, I; Skupińska, K, 2004)	2.49
"Sulforaphane is a chemical found in cruciferous vegetables such as broccoli, sprouts and kale. "	( Sulforaphane halts breast cancer cell growth. Johnston, N, 2004)	3.21
"Sulforaphane (SFN) is a major isothiocyanate compound in cruciferous vegetables such as broccoli, cauliflower, and Brussels sprouts. "	( Involvement of c-Jun N-terminal kinase in G2/M arrest and caspase-mediated apoptosis induced by sulforaphane in DU145 prostate cancer cells. Cho, SD; Hu, H; Jiang, C; Kang, KS; Kim, SH; Lee, YS; Li, G; Lu, J, 2005)	1.99
"Sulforaphane is an isothiocyanate that is present naturally in widely consumed Brassica oleracea vegetables and has been shown to block the formation of tumors. "	( Purification of sulforaphane from Brassica oleracea seed meal using low-pressure column chromatography. Liang, H; Xiao, Q; Yuan, Q, 2005)	2.12
"Sulforaphane is an electrophile that can react with protein thiols to form thionoacyl adducts."	( Identification of sensor cysteines in human Keap1 modified by the cancer chemopreventive agent sulforaphane. Freeman, ML; Hong, F; Liebler, DC, 2005)	1.27
"Sulforaphane (SFN) is an isothiocyanate from broccoli that induces phase 2 detoxification enzymes. "	( Sulforaphane inhibits histone deacetylase in vivo and suppresses tumorigenesis in Apc-minus mice. Dashwood, RH; Dashwood, WM; Ho, E; Myzak, MC; Orner, GA, 2006)	3.22
"Sulforaphane is a chemopreventive agent present in various cruciferous vegetables, including broccoli. "	( Sulforaphane sensitizes tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-resistant hepatoma cells to TRAIL-induced apoptosis through reactive oxygen species-mediated up-regulation of DR5. Choi, KS; Eom, YW; Kim, EH; Kim, H; Kim, WH; Kwon, TK; Lee, SJ, 2006)	3.22
"Sulforaphane (SFN) is an activator of the transcription factor Nrf2, which plays a critical role in metabolism and excretion of xenobiotics. "	( Sulforaphane, an activator of Nrf2, suppresses cellular accumulation of arsenic and its cytotoxicity in primary mouse hepatocytes. Fukami, I; Ishii, T; Kumagai, Y; Shinkai, Y; Sumi, D, 2006)	3.22
"Sulforaphane (SFN) is a potent and promising naturally occurring dietary cancer chemopreventive compound that exerts its cancer protective effects by the induction of genes including cellular defensive genes such as phase II detoxifying and antioxidant enzymes. "	( Gene expression profiles induced by cancer chemopreventive isothiocyanate sulforaphane in the liver of C57BL/6J mice and C57BL/6J/Nrf2 (-/-) mice. Chan, JY; Gopalkrishnan, A; Hu, R; Jain, MR; Khor, TO; Kong, AN; Lin, W; Reddy, B; Shen, G; Xu, C, 2006)	2.01
"Sulforaphane (SFN) is an isothiocyanate found in cruciferous vegetables, with particularly high levels detected in broccoli and broccoli sprouts. "	( Chemoprotection by sulforaphane: keep one eye beyond Keap1. Dashwood, RH; Myzak, MC, 2006)	2.1
"Sulforaphane (SFN) is an isothiocyanate that is present abundantly in widely consumed cruciferous vegetables and has a particularly high content in broccoli and cauliflower. "	( Cancer chemoprevention of intestinal polyposis in ApcMin/+ mice by sulforaphane, a natural product derived from cruciferous vegetable. Chada, K; Chen, C; Hebbar, V; Hu, R; Jeong, WS; Khor, TO; Kong, AN; Reddy, B; Shen, G; Xu, C, 2006)	2.01
"Sulforaphane is a particularly promising chemopreventive agent, which has been shown to exert proapoptotic effects on tumor cells containing p53 mutations."	( Sulforaphane increases the efficacy of doxorubicin in mouse fibroblasts characterized by p53 mutations. Cantelli-Forti, G; Fimognari, C; Hrelia, P; Lenzi, M; Nüsse, M; Sciuscio, D, 2006)	2.5
"Sulforaphane (SFN) is an isothiocyanate that is present in widely consumed vegetables. "	( Pharmacogenomics of cancer chemopreventive isothiocyanate compound sulforaphane in the intestinal polyps of ApcMin/+ mice. Chada, K; Chen, C; Hebbar, V; Hu, R; Jeong, WS; Khor, TO; Kong, AN; Nair, S; Reddy, B; Shen, G; Xu, C, 2006)	2.01
"Sulforaphane (SFN) is a biologically active phytochemical found abundantly in broccoli. "	( The dietary isothiocyanate sulforaphane is an antagonist of the human steroid and xenobiotic nuclear receptor. Bammler, TK; Blumberg, B; Eaton, DL; Grün, F; Poulton, EJ; Thummel, KE; Zhou, C, 2007)	2.08
"Sulforaphane (SFN) is an isothiocyanate found in cruciferous vegetables such as broccoli. "	( Sulforaphane retards the growth of human PC-3 xenografts and inhibits HDAC activity in human subjects. Dashwood, RH; Dashwood, WM; Ho, E; Myzak, MC; Tong, P, 2007)	3.23
"Sulforaphane (SF) is a drug identified as a potent inducer of QR1 in various non-neuronal cells."	( Protective effect of sulforaphane against dopaminergic cell death. Han, JM; Hwang, O; Kim, EM; Kim, HW; Lee, SY; Lee, YJ; Moon, Y, 2007)	1.38
"Sulforaphane (SFN) is an isothiocyanate that is present in widely consumed vegetables. "	( Cell-cycle specificity of sulforaphane-mediated apoptosis in Jurkat T-leukemia cells. Cantelli-Forti, G; Fimognari, C; Hrelia, P; Lenzi, M; Sciuscio, D, )	1.87
"Sulforaphane (SFN) is an isothiocyanate that is found in abundant quantities in many cruciferous vegetables including broccoli and cauliflower. "	( Induction of apoptosis by isothiocyanate sulforaphane in human cervical carcinoma HeLa and hepatocarcinoma HepG2 cells through activation of caspase-3. Bae, SJ; Choi, YH; Kim, GY; Park, SY; Yoo, YH, 2007)	2.05
"Sulforaphane (SFN) is an isothiocyanate found in cruciferous vegetables, such as broccoli and broccoli sprouts. "	( Dietary histone deacetylase inhibitors: from cells to mice to man. Dashwood, RH; Ho, E, 2007)	1.78
"Sulforaphane (SF) is a phytochemical that displays both anticarcinogenic and anticancer activity. "	( Discovery and development of sulforaphane as a cancer chemopreventive phytochemical. Tang, L; Zhang, Y, 2007)	2.07
"Sulforaphane (SFN) is a major ITC present in broccoli."	( Sulforaphane induces growth arrest and apoptosis in human ovarian cancer cells. Chiao, JW; Chuang, LT; Gretz, HF; Moqattash, ST; Nezhat, F; Rahaman, J, 2007)	2.5
"Sulforaphane is a naturally occurring isothiocyanate with promising chemopreventive activity. "	( Absolute bioavailability and dose-dependent pharmacokinetic behaviour of dietary doses of the chemopreventive isothiocyanate sulforaphane in rat. Coldham, N; Gielbert, A; Hanlon, N; Ioannides, C; King, LJ; Kuhnert, N; Sauer, MJ, 2008)	2
"Sulforaphane is a natural, biologically active compound extracted from cruciferous vegetables such as broccoli and cabbage. "	( Sulforaphane suppresses lipopolysaccharide-induced cyclooxygenase-2 (COX-2) expression through the modulation of multiple targets in COX-2 gene promoter. Kwon, TK; Woo, KJ, 2007)	3.23
"Sulforaphane is an antioxidant and a potent stimulator of natural detoxifying enzyme and associated with lowered risk of cancer that is associated with the consumption of cruciferous vegetables. "	( Efficacy of sulforaphane is mediated by p38 MAP kinase and caspase-7 activations in ER-positive and COX-2-expressed human breast cancer cells. Ahn, NS; Hwang, JW; Jo, EH; Kang, KS; Kim, SH; Lee, YS; Park, JS, 2007)	2.16
"Sulforaphane (SFN) is an isothiocyanate found in cruciferous vegetables. "	( Sulforaphane inhibition of monocyte adhesion via the suppression of ICAM-1 and NF-kappaB is dependent upon glutathione depletion in endothelial cells. Chuang, SH; Hsieh, CW; Hsieh, CY; Liu, YC; Weng, YC; Wung, BS, 2008)	3.23
"Sulforaphane, which is a naturally occurring isothiocyanate that is present in cruciferous vegetables such as broccoli, is known to be an indirect antioxidant that acts by inducing Nrf2-dependent phase 2 enzymes."	( Sulforaphane protects kidneys against ischemia-reperfusion injury through induction of the Nrf2-dependent phase 2 enzyme. Jang, KY; Kang, NI; Lee, HK; Park, BH; Park, JW; Yoon, HY, 2008)	2.51
"Sulforaphane (SFN) is an isothiocyanate found in cruciferous vegetables and is especially high in broccoli and broccoli sprouts."	( Multi-targeted prevention of cancer by sulforaphane. Clarke, JD; Dashwood, RH; Ho, E, 2008)	1.34
"Sulforaphane (SFN) is a naturally occurring isothiocyanate present in cruciferous vegetables, such as broccoli, that has been identified as a potent inducer of glutathione S-transferase activities in laboratory animals. "	( Biotransformation of the naturally occurring isothiocyanate sulforaphane in the rat: identification of phase I metabolites and glutathione conjugates. Baillie, T; Davis, M; Hu, P; Kassahun, K; Martin, B, 1997)	1.98
"Sulforaphane is an isothiocyanate that is present naturally in widely consumed vegetables and has a particularly high concentration in broccoli. "	( Sulforaphane, a naturally occurring isothiocyanate, induces cell cycle arrest and apoptosis in HT29 human colon cancer cells. Cassar, G; Chevolleau, S; Dupont, MA; Gamet-Payrastre, L; Gasc, N; Li, P; Lumeau, S; Tercé, F; Tulliez, J, 2000)	3.19
"Sulforaphane is a monofunctional inducer, like other anticarcinogenic isothiocyanates, and induces phase II enzymes selectively without the induction of aryl hydrocarbon receptor-dependent cytochromes P-450 (phase I enzymes)."	( A major inducer of anticarcinogenic protective enzymes from broccoli: isolation and elucidation of structure. Cho, CG; Posner, GH; Talalay, P; Zhang, Y, 1992)	1

Excerpt	Reference	Relevance
"Sulforaphane (SFN) has a strong anti-inflammatory ability and a certain protective effect on intestinal diseases."	( The Protective Effect of Sulforaphane on ER-induced Apoptosis and Inflammation in Necrotizing Enterocolitis Mice. Bao, Z; Mi, Y; Wang, X; Xiong, X, 2023)	1.93
"Sulforaphane (SFN) has received a great deal of attention as potent antioxidant because of its ability to induce expression of antioxidant enzymes through nuclear factor (erythroid-derived 2)-like 2 (NRF2) signaling pathway."	( The protective effect of sulforaphane against oxidative stress in granulosa cells of patients with polycystic ovary syndrome (PCOS) through activation of AMPK/AKT/NRF2 signaling pathway. Amidi, F; Hayati Roudbari, N; Parivar, K; Taheri, M, 2021)	1.65
"Sulforaphane (SFN) has a strong anti-inflammatory ability and a certain protective effect on intestinal diseases."	( The Protective Effect of Sulforaphane on ER-induced Apoptosis and Inflammation in Necrotizing Enterocolitis Mice. Bao, Z; Mi, Y; Wang, X; Xiong, X, 2023)	1.93
"Sulforaphane has been investigated in human pathologies and preclinical models of airway diseases. "	( Sulforaphane prevents and reverses allergic airways disease in mice via anti-inflammatory, antioxidant, and epigenetic mechanisms. Beh, RC; Bourke, JE; Donovan, C; El-Osta, A; Hung, A; Karagiannis, TC; Khurana, I; Liang, JJ; Licciardi, PV; Maxwell, S; Mazarakis, N; Pitsillou, E; Royce, SG; Samuel, CS; Siow, YY; Snibson, KJ; Tang, MLK; Tobin, MJ; Ververis, K; Vongsvivut, J; Ziemann, M, 2022)	3.61
"Sulforaphane (SFN) has been proven to be effective in alleviating many metabolic diseases, such as obesity and type 2 diabetes."	( The protective effects of sulforaphane on high-fat diet-induced metabolic associated fatty liver disease in mice Hu, Q; Li, X; Lu, Y; Ma, S; Pang, X; Sun, J; Tian, S, 2022)	1.74
"Sulforaphane (SFN) has neuroprotective effects for AD."	( Sulforaphane attenuates microglia-mediated neuronal damage by down-regulating the ROS/autophagy/NLRP3 signal axis in fibrillar Aβ-activated microglia. Dong, B; Fu, Y; Gong, M; Liu, T; Lü, T; Qiu, P; Wang, Y; Xie, W; Yang, C; Yang, Y; Zhang, J, 2023)	3.07
"Sulforaphane has several effects on the human body, including anti-inflammation, antioxidation, antimicrobial and anti-obesity effects. "	( Sulforaphane Attenuates Neutrophil ROS Production, MPO Degranulation and Phagocytosis, but Does Not Affect NET Formation Ex Vivo and In Vitro. Ma, S; Ruhee, RT; Seki, Y; Suzuki, K; Tong, Y; Wakasugi-Onogi, S, 2023)	3.8
"Sulforaphane (SFN) has been shown to have anti-inflammatory and antioxidant properties."	( Sulforaphane alleviates psoriasis by enhancing antioxidant defense through KEAP1-NRF2 Pathway activation and attenuating inflammatory signaling. Gu, C; Huang, Z; Li, L; Lian, P; Lu, R; Lu, Y; Ma, C; Peng, Z; Pu, W; Ruan, B; Su, Z; Wang, H; Wang, W; Wazir, J; Wei, L; Zong, Y, 2023)	3.07
"Sulforaphane (SFN) has been shown to induce the production of reactive oxygen species (ROS) and inhibit epidermal growth factor receptor (EGFR)-mediated signaling in non-small-cell lung cancer (NSCLC). "	( High levels of EGFR prevent sulforaphane-induced reactive oxygen species-mediated apoptosis in non-small-cell lung cancer cells. Chen, CC; Chen, CY; Huang, KY; Shih, YM; Wang, TH, 2019)	2.25
"Sulforaphane (SFN) has been documented to possess anticancer properties. "	( Development of Prolamin-Based Composite Nanoparticles for Controlled Release of Sulforaphane. Rao, P; Rose, D; Wang, L; Zhang, Y, 2020)	2.23
"Sulforaphane has demonstrated great antitumor activity and is able to significantly inhibit proliferation, viability, migration, malignancy, and epithelial-to-mesenchymal transition of cancer cells."	( MicroRNAs as novel targets of sulforaphane in cancer therapy: The beginning of a new tale? Ahmadi, Z; Ashrafizadeh, M; Rafiei, H, 2020)	1.57
"Sulforaphane (SFN) has antioxidant and anti‑tumor activities."	( Sulforaphane suppresses the viability and metastasis, and promotes the apoptosis of bladder cancer cells by inhibiting the expression of FAT‑1. An, H; Liu, P; Wang, F; Zhang, Y, 2020)	2.72
"Sulforaphane (SFN) has been identified by the National Cancer Institute as a candidate for chemopreventive research; it is one of several compounds selected by the National Cancer Institute's Rapid Access to Preventive Intervention Development Program and is currently in use."	( Identification of sulforaphane regulatory network in hepatocytes by microarray data analysis based on GEO database. Cai, D; Gao, L; Liu, J; Wang, J; Wang, Y; Zhang, S; Zhang, X; Zhao, Y, 2021)	1.68
"Sulforaphane (SFN) has received a great deal of research attention because of its ability to induce the production of a battery of antioxidant enzymes in certain concentrations through the activation of the Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) signaling pathway, which may effectively neutralize reactive oxygen species (ROS) induced oxidative stress. "	( Concentration dependent antioxidative and apoptotic effects of sulforaphane on bovine granulosa cells in vitro. Akyuz, B; Arslan, K; Cinar, MU; Konca, Y; Sariozkan, S; Sohel, MMH, 2017)	2.14
"Sulforaphane (SFN) has been suggested as a new potential anti-diabetic compound."	( Sulforaphane improves disrupted ER-mitochondria interactions and suppresses exaggerated hepatic glucose production. Axelsson, AS; Rieusset, J; Rosengren, AH; Tubbs, E; Vial, G; Wollheim, CB, 2018)	2.64
"Sulforaphane (SFN) has been confirmed to be an effective antioxidant in the treatment of many diseases."	( Protective effect of sulforaphane against retinal degeneration in the Pde6 Kang, K; Yu, M, 2017)	1.5
"Sulforaphane (SFN) has been revealed to inhibit the growth and induce apoptosis of cancer cells. "	( Sulforaphane induces p53‑deficient SW480 cell apoptosis via the ROS‑MAPK signaling pathway. Lan, H; Lin, C; Yuan, H, 2017)	3.34
"Sulforaphane has decreased the level of thymidylate synthetase, which was also observed in the case of the sequential sulforaphane and 5-fluorouracil treatment."	( Autophagic cell death and premature senescence: New mechanism of 5-fluorouracil and sulforaphane synergistic anticancer effect in MDA-MB-231 triple negative breast cancer cell line. Chilmonczyk, Z; Dąbrowska, A; Koronkiewicz, M; Lubelska, K; Matosiuk, D; Mielczarek, L; Milczarek, M; Wiktorska, K, 2018)	1.43
"L-Sulforaphane) have been found to restore normal gene expression levels in diseases including cancer via the activity of histone deacetylases and DNA methyltransferases, thus retarding disease progression."	( L-Sulforaphane Confers Protection Against Oxidative Stress in an In Vitro Model of Age-Related Macular Degeneration. Dias, DA; Dulull, NK; Kwa, FAA; Thrimawithana, TR, 2018)	1.76
"Sulforaphane (SFN) has been considered as an indirect antioxidant and potential inducer of the Nrf2-ARE pathway. "	( Sulforaphane protects granulosa cells against oxidative stress via activation of NRF2-ARE pathway. Amin, A; Hoelker, M; Linares-Otoya, L; Prastowo, S; Schellander, K; Sohel, MMH; Tesfaye, D, 2018)	3.37
"Sulforaphane has been shown to suppress tumour growth by several mechanisms including inhibiting histone deacetylases."	( Sulforaphane absorption and histone deacetylase activity following single dosing of broccoli sprout supplement in normal dogs. Beaver, LM; Bracha, S; Curran, KM; Ho, E; Stevens, JF; Wong, CP, 2018)	2.64
"Sulforaphane (SFN) has been shown to protect the brain vascular system and effectively reduce ischemic injuries and cognitive deficits. "	( In Vitro Modulation of Redox and Metabolism Interplay at the Brain Vascular Endothelium: Genomic and Proteomic Profiles of Sulforaphane Activity. Cucullo, L; Desai, VG; Kaisar, MA; Prasad, S; Sajja, RK; Vijay, V, 2018)	2.13
"Sulforaphane (SFN) has shown anti-cancer effects in cellular and animal studies but its effectiveness has been limited in human studies. "	( Antioxidant effects of sulforaphane in human HepG2 cells and immortalised hepatocytes. Bao, Y; Bowater, RP; Liu, P; Tang, J; Wang, W, 2019)	2.27
"Sulforaphane has received considerable attention in recent years due to its antioxidant and anti-inflammatory properties. "	( Sulforaphane treatment reverses corticosteroid resistance in a mixed granulocytic mouse model of asthma by upregulation of antioxidants and attenuation of Th17 immune responses in the airways. Ahmad, SF; Al-Harbi, MM; Al-Harbi, NO; Alqahtani, F; Alqinyah, M; AlThagfan, SS; Ibrahim, KE; Nadeem, A, 2019)	3.4
"Sulforaphane has antioxidant properties via Nrf2 activation."	( Contrast media (meglumine diatrizoate) aggravates renal inflammation, oxidative DNA damage and apoptosis in diabetic rats which is restored by sulforaphane through Nrf2/HO-1 reactivation. Abd-Allah, AR; Abdel-Hamied, HE; Alzokaky, AA; Ashour, AA; Ewees, MG; Khaleel, SA; Raslan, NA, 2019)	1.44
"Sulforaphane has been shown to display anti-cancer properties against various cancer cell lines."	( Sulforaphane controls TPA-induced MMP-9 expression through the NF-κB signaling pathway, but not AP-1, in MCF-7 breast cancer cells. Chung, EY; Han, JH; Hwang, BM; Jung, SH; Kim, BS; Kim, JM; Kim, JS; Lee, SH; Lee, YR; Noh, EM; Youn, HJ, 2013)	2.55
"Sulforaphane (SFN) has been reported to regulate signaling pathways relevant to chronic diseases. "	( Sulforaphane represses matrix-degrading proteases and protects cartilage from destruction in vitro and in vivo. Bao, Y; Clark, IM; Culley, KL; Davidson, RK; de Ferrars, R; Donell, ST; Driscoll, C; Jupp, O; Kay, CD; Norton, R; Vincent, TL, 2013)	3.28
"Sulforaphane has therapeutic potential for management of the late effects of radiation."	( Sulforaphane mitigates genotoxicity induced by radiation and anticancer drugs in human lymphocytes. Adhikari, JS; Agrawala, PK; Dwarakanath, BS; Katoch, O; Kumar, A, 2013)	2.55
"Sulforaphane (SFN) has been considered a promising chemotherapeutic compound for several types of tumors by inducing apoptosis and cytostasis, but its effects (e.g., genotoxicity) in osteosarcoma cells remains exploratory."	( Sulforaphane induces DNA damage and mitotic abnormalities in human osteosarcoma MG-63 cells: correlation with cell cycle arrest and apoptosis. Costa, M; Ferreira de Oliveira, JM; Oliveira, H; Pinho, F; Pinho, S; Pinto, P; Remédios, C; Santos, C, 2014)	2.57
"Sulforaphane (SF) has received much attention because of its anticarcinogenic, antioxidant and anti-inflammatory properties, but it is quite unstable. "	( Stability and encapsulation efficiency of sulforaphane microencapsulated by spray drying. Huang, J; Liu, S; Mao, J; Wu, Y; Zou, L, 2014)	2.11
"Sulforaphane has been reported to protect against oxidative stress-mediated cell and tissue injury."	( Sulforaphane reduces advanced glycation end products (AGEs)-induced inflammation in endothelial cells and rat aorta. Matsui, T; Nakamura, N; Nishino, Y; Ojima, A; Yamagishi, SI, 2016)	2.6
"Sulforaphane has been shown to induce expression of antioxidant genes via activation of a transcription factor, nuclear factor erythroid-2 related factor 2 (Nrf2)."	( Lack of Effect of Oral Sulforaphane Administration on Nrf2 Expression in COPD: A Randomized, Double-Blind, Placebo Controlled Trial. Berenson, CS; Biswal, S; Burke, A; Criner, G; Fahey, JW; Holbrook, JT; Jacobs, MR; Rayapudi, S; Sethi, S; Singh, A; Sudini, KR; Sugar, EA; Talalay, P; Thimmulappa, R; Wise, RA, 2016)	1.47
"Sulforaphane has been reported to inhibit pancreatic tumor-initiating cells and breast cancer stem cells."	( Implications of cancer stem cell theory for cancer chemoprevention by natural dietary compounds. Li, Y; Schwartz, SJ; Sun, D; Wicha, MS, 2011)	1.09
"Sulforaphane (SFN) has been indicated for the prevention and suppression of tumorigenesis in solid tumors. "	( Sulforaphane potentiates the efficacy of imatinib against chronic leukemia cancer stem cells through enhanced abrogation of Wnt/β-catenin function. Kuo, CC; Lee, CM; Lin, LC; Wang, LS; Wu, AT; Wu, CH; Yang, WC; Yeh, CT; Yen, GC, 2012)	3.26

Excerpt	Reference	Relevance
"This sulforaphane-related increase of MRP2 mRNAs paralleled increased expression of 190 kD MRP2 protein as assessed by Western blotting; it was fully abolished by the transcription inhibitor actinomycin D."	( Reactive oxygen species-related induction of multidrug resistance-associated protein 2 expression in primary hepatocytes exposed to sulforaphane. Courtois, A; Fardel, O; Guillouzo, A; Loewert, M; Payen, L, 2001)	0.97
"Sulforaphane (SFN) promotes protective effects in different cell types. "	( The isothiocyanate sulforaphane prevents mitochondrial impairment and neuroinflammation in the human dopaminergic SH-SY5Y and in the mouse microglial BV2 cells: role for heme oxygenase-1. Brasil, FB; Dall'Oglio, EL; de Almeida, FJS; de Oliveira, MR; Luckachaki, MD, 2023)	2.68
"Sulforaphane appears to inhibit sCC progression by impacting its growth and invasion ability, and regulates miR-199a-5p/Sirt1 and CD44ICD signaling pathways, and may be utilized to develop a curative approach for sSCC."	( Sulforaphane suppresses skin squamous cell carcinoma cells proliferation through miR-199a-5p/Sirt1/CD44ICD signaling pathway. Ai, P; Chen, SZ; Lei, SY; Zhang, Y, 2023)	3.8
"Sulforaphane could lower uric acid by decreasing urate synthesis and increasing renal urate excretion in hyperuricemic rats (P＜0.05). "	( Sulforaphane-driven reprogramming of gut microbiome and metabolome ameliorates the progression of hyperuricemia. Halimulati, M; Huang, X; Li, L; Ma, Y; Wang, R; Zhang, Z, 2023)	3.8
"Sulforaphane was shown to increase the accumulation of doxorubicin in the nuclei of cancer cells, accompanied by inhibition of mitosis, without affecting the reactive oxygen species status of the cell."	( Anticancer effect and safety of doxorubicin and nutraceutical sulforaphane liposomal formulation in triple-negative breast cancer (TNBC) animal model. Fronczyk, K; Mazur, M; Pogorzelska, A; Sigorski, D; Świtalska, M; Wietrzyk, J; Wiktorska, K, 2023)	1.87
"Sulforaphane (SFN)displays both anti-oxidative stress and anti-inflammatory activity. "	( Sulforaphane alleviates hepatic ischemia-reperfusion injury through promoting the activation of Nrf-2/HO-1 signaling. Chen, L; Jia, W; Xie, DQ; Zhang, WL, 2021)	3.51
"Sulforaphane can inhibit the inflammatory response and oxidative stress induced by HI/RI through promoting the activation of the Nrf-2 / HO-1 signal pathway."	( Sulforaphane alleviates hepatic ischemia-reperfusion injury through promoting the activation of Nrf-2/HO-1 signaling. Chen, L; Jia, W; Xie, DQ; Zhang, WL, 2021)	3.51
"Sulforaphane could suppress the proliferation of BIU87 cells via enhancing IGFBP-3 expression, which negatively regulating the NF-κB signaling pathway."	( Sulforaphane inhibits the proliferation of the BIU87 bladder cancer cell line via IGFBP-3 elevation. Chen, C; Chen, YR; Dang, YM; Dang, ZF; Guo, YF; Huang, G; Liu, FL; Xie, XD, 2014)	3.29
"Sulforaphane does not inhibit the inflammasome by direct modification of active caspase-1 and its mechanism is not dependent on protein degradation by the proteasome or de novo protein synthesis."	( Sulforaphane inhibits multiple inflammasomes through an Nrf2-independent mechanism. Greaney, AJ; Leppla, SH; Maier, NK; Moayeri, M, 2016)	2.6
"Sulforaphane promotes polarization of microglia from the M1 to the M2 phenotype, reducing IL-1b and increasing IL-4, IL-10, Arg1, and YM-1 in the cerebellum."	( Neuroinflammation increases GABAergic tone and impairs cognitive and motor function in hyperammonemia by increasing GAT-3 membrane expression. Reversal by sulforaphane by promoting M2 polarization of microglia. Agusti, A; Balzano, T; Cabrera-Pastor, A; Felipo, V; Gonzalez-Usano, A; Hernandez-Rabaza, V; Llansola, M; Taoro-Gonzalez, L, 2016)	1.35
"Sulforaphane displays a distinctly different pattern of Keap1 modification than previously studied ARE inducers that modify Keap1 by alkylation."	( Identification of sensor cysteines in human Keap1 modified by the cancer chemopreventive agent sulforaphane. Freeman, ML; Hong, F; Liebler, DC, 2005)	1.27
"Sulforaphane was used to activate Nrf2."	( Transcription factor Nrf2 protects the brain from damage produced by intracerebral hemorrhage. Aronowski, J; Dash, PK; Grotta, JC; Kan, YW; Strong, R; Sun, G; Zhang, J; Zhao, X, 2007)	1.06
"Sulforaphane was unable to inhibit mutagenicity of sodium azide (5 micrograms/plate), a direct acting mutagen, in the Salmonella assay."	( CYP2E1-mediated mechanism of anti-genotoxicity of the broccoli constituent sulforaphane. Barcelo, S; Chipman, JK; Gardiner, JM; Gescher, A, 1996)	1.25

Excerpt	Reference	Relevance
"Sulforaphane (SFP) treatment represses oxidative stress by activating NRF2. "	( Sulforaphane alleviates hypoxic vestibular vertigo (HVV) by increasing NO production via upregulating the expression of NRF2. Hu, C; Li, Y; Wang, B; Zhou, L, 2022)	3.61
"Sulforaphane (SFN) treatment has shown to induce the phagocytic activity of Aβo treated microglial cells."	( Sulforaphane Attenuates Aβ Oligomers Mediated Decrease in Phagocytic Activity of Microglial Cells. Chilakala, RR; Kumar, A; Manchikalapudi, AL; Sunkaria, A, 2020)	2.72
"Sulforaphane-treated human dendritic cells were matured "	( Sulforaphane Promotes Dendritic Cell Stimulatory Capacity Through Modulation of Regulatory Molecules, JAK/STAT3- and MicroRNA-Signaling. Gretz, N; Gross, W; Herr, I; Karakhanova, S; Petrikova, E; Sticht, C; Wang, Y, 2020)	3.44
"Sulforaphane treatment reduced the arthritis score and the severity of histologic inflammation in CIA mice."	( The anti-arthritis effect of sulforaphane, an activator of Nrf2, is associated with inhibition of both B cell differentiation and the production of inflammatory cytokines. Cho, ML; Jhun, J; Jung, K; Kim, SY; Kwon, JY; Min, JK; Moon, SJ; Ryu, J, 2021)	1.63
"The sulforaphane- or albumin-treated groups showed reduced concentrations of reactive oxygen species (P < 0.04), nitric oxide (P < 0.001), and peroxynitrite (P = 0.001), compared with I/R injury untreated animals."	( Sulforaphane and Albumin Attenuate Experimental Intestinal Ischemia-Reperfusion Injury. Bittencourt Rosas, SL; Dos Santos Valença, S; Franco, OB; Lima Castelo-Branco, MT; Lopes Lichtenberger, RC; Maran Carra, A; Pereira de Souza, HS; Ribeiro, BE; Sampaio de Holanda, G; Santana, PT; Schanaider, A, 2021)	2.54
"Sulforaphane treatment led to induction of antioxidant enzymes (SOD, GPx) in AECs and pulmonary non-enzymatic antioxidants."	( Sulforaphane treatment reverses corticosteroid resistance in a mixed granulocytic mouse model of asthma by upregulation of antioxidants and attenuation of Th17 immune responses in the airways. Ahmad, SF; Al-Harbi, MM; Al-Harbi, NO; Alqahtani, F; Alqinyah, M; AlThagfan, SS; Ibrahim, KE; Nadeem, A, 2019)	2.68
"As sulforaphane pretreatment led to a moderate increase in peroxynitrite generation, we suggest that hormetic preconditioning underlies sulforaphane-mediated protection against stroke."	( Sulforaphane preconditioning of the Nrf2/HO-1 defense pathway protects the cerebral vasculature against blood-brain barrier disruption and neurological deficits in stroke. Alfieri, A; Cash, D; Duchen, MR; Fraser, PA; Mann, GE; Modo, M; Siow, RCM; Srivastava, S; Williams, SCR, 2013)	2.35
"The sulforaphane treatment activated Nrf2, increased levels of the Nrf2 target heme oxygenase-1 and subsequently lowered oxidant stress as shown by the decline in lipid peroxidation and 3-nitrotyrosine protein adducts and an increase in GSH levels after the acute ethanol treatment. "	( Sulforaphane induces Nrf2 and protects against CYP2E1-dependent binge alcohol-induced liver steatosis. Lin, J; Wu, D; Zhou, R, 2014)	2.4
"Sulforaphane treatment was unable to protect Nrf2 knockout mouse embryonic fibroblasts, indicating that the sulforaphane-induced radioprotection was Nrf2-dependent."	( Repeated Nrf2 stimulation using sulforaphane protects fibroblasts from ionizing radiation. Bergström, P; Hammarsten, O; Mathew, ST, 2014)	1.41
"Sulforaphane (80 μM) treatment could inhibit cell proliferation, inducing apoptosis and cell cycle arrest at G2/M phase. "	( Sulforaphane inhibits the proliferation of the BIU87 bladder cancer cell line via IGFBP-3 elevation. Chen, C; Chen, YR; Dang, YM; Dang, ZF; Guo, YF; Huang, G; Liu, FL; Xie, XD, 2014)	3.29
"Sulforaphane treatment significantly attenuated ischemic-induced loss of retinal function as compared to vehicle treated mice."	( Protection of retinal function by sulforaphane following retinal ischemic injury. Ambrecht, LA; Bu, P; McDonnell, JF; Perlman, JI; Qiao, L; Zhai, Y, 2015)	1.42
"Sulforaphane treatment resulted in a dose-dependent increase in the levels of tumor suppressive miR200c."	( Sulforaphane targets cancer stemness and tumor initiating properties in oral squamous cell carcinomas via miR-200c induction. Liao, YW; Liu, CM; Lu, MY; Peng, CY; Tsai, ML; Yeh, JC; Yu, CC; Yu, CH, 2017)	2.62
"Sulforaphane treatment for 4 or 24 h dose-dependently inhibited the AGEs-induced increase in RAGE, monocyte chemoattractant protein-1 (MCP-1), intercellular adhesion molecule-1 (ICAM-1), and vascular cell adhesion molecular-1 (VCAM-1) gene expression in HUVECs."	( Sulforaphane reduces advanced glycation end products (AGEs)-induced inflammation in endothelial cells and rat aorta. Matsui, T; Nakamura, N; Nishino, Y; Ojima, A; Yamagishi, SI, 2016)	2.6
"Sulforaphane treatment of Het-1A, a normal mucosal epithelial cell line, and 4 HNSCC cell lines led to dose- and time-dependent induction of NRF2 and the NRF2 target genes NQO1 and GCLC, known mediators of carcinogen detoxication."	( Prevention of Carcinogen-Induced Oral Cancer by Sulforaphane. Bauman, JE; Egner, PA; Fahey, JW; Grandis, JR; Johnson, DE; Kensler, TW; Li, C; Normolle, DP; Sen, M; Wang, L; Zang, Y, 2016)	1.41
"Sulforaphane pretreatment significantly increased the nuclear Nrf2, HO1, and NQO1 levels in TNC."	( Activation of the nuclear factor E2-related factor 2/anitioxidant response element alleviates the nitroglycerin-induced hyperalgesia in rats. Di, W; Fang, Y; Li, Z; Liu, J; Lv, H; Shi, X; Zhang, H, 2016)	1.16
"Sulforaphane treatment significantly reduced infarct volume and improved neurological scores when compared to a vehicle-treated group."	( Sulforaphane improves outcomes and slows cerebral ischemic/reperfusion injury via inhibition of NLRP3 inflammasome activation in rats. He, Q; Hou, YH; Li, LY; Song, FZ; Yu, C; Zheng, J, 2017)	2.62
"Sulforaphane pretreatment significantly limited lung RSV replication and virus-induced inflammation in Nrf2(+/+) but not in Nrf2(-/-) mice."	( Antiviral activity of Nrf2 in a murine model of respiratory syncytial virus disease. Cho, HY; Imani, F; Kleeberger, SR; Melendi, GA; Miller-DeGraff, L; Polack, FP; Walters, D; Yamamoto, M, 2009)	1.07
"Sulforaphane treatment restored bacteria recognition and phagocytosis in alveolar macrophages from COPD patients."	( Targeting Nrf2 signaling improves bacterial clearance by alveolar macrophages in patients with COPD and in a mouse model. Biswal, S; Brown, RH; Feller-Kopman, D; Harvey, CJ; Kong, X; Sethi, S; Thimmulappa, RK; Wise, R; Yarmus, L, 2011)	1.09
"Sulforaphane treatment also resulted in apoptosis as evidenced by an increase in annexin V+/propidium iodide- (V+/PI-) cells, the cleavage of 116-kDa poly (ADP-ribose) polymerase (PARP) and ICAD and oligonucleosomal DNA fragmentation."	( Induction of G₂/M arrest and apoptosis by sulforaphane in human osteosarcoma U2-OS cells. Kim, JR; Kim, MR; Park, BH; Zhou, L, )	1.12
"Sulforaphane treatment also increases cleavage of procaspase 3, 8, and 9 and enhances PARP cleavage and apoptosis."	( Sulforaphane suppresses polycomb group protein level via a proteasome-dependent mechanism in skin cancer cells. Balasubramanian, S; Chew, YC; Eckert, RL, 2011)	2.53
"Sulforaphane treatment decreased cell viability and triggered a rapid and transient increase in the intracellular ROS levels."	( Reactive oxygen species and PI3K/Akt signaling play key roles in the induction of Nrf2-driven heme oxygenase-1 expression in sulforaphane-treated human mesothelioma MSTO-211H cells. Cho, MK; Jeong, HY; Kim, YB; Lee, SH; Lee, YJ; Nam, HS; Shim, JH; Won, SY, 2012)	1.31
"Sulforaphane-treated cells accumulated in metaphase as determined by flow cytometry [4C DNA content, cyclin A(-), cyclin B1(+), and phospho-histone H3 (Ser(10))(+)]."	( The dietary isothiocyanate sulforaphane targets pathways of apoptosis, cell cycle arrest, and oxidative stress in human pancreatic cancer cells and inhibits tumor growth in severe combined immunodeficient mice. Cao, P; Gronda, M; Hedley, DW; Jacobberger, JW; Pham, NA; Schimmer, AD, 2004)	1.34
"Sulforaphane pretreatment inhibited IL-8 production by BEAS-2B cells upon stimulation with diesel extract."	( Sulforaphane-stimulated phase II enzyme induction inhibits cytokine production by airway epithelial cells stimulated with diesel extract. Diaz-Sanchez, D; Ritz, SA; Wan, J, 2007)	2.5
"Sulforaphane treatment inhibited cell growth, induced a G(2)-M cell cycle block, increased expression of cyclin B1, and induced oligonucleosomal DNA fragmentation in the four human breast cancer cell lines examined, MDA-MB-231, MDA-MB-468, MCF-7, and T47D cells."	( Sulforaphane induces cell type-specific apoptosis in human breast cancer cell lines. Davidson, NE; Pledgie-Tracy, A; Sobolewski, MD, 2007)	2.5
"Pretreatment with sulforaphane either completely prevented or significantly reduced markers of both oxidative stress and mitochondrial dysfunction."	( Protective Effect of Sulforaphane on Oxidative Stress and Mitochondrial Dysfunction Associated with Status Epilepticus in Immature Rats. Folbergrová, J; Ješina, P; Otáhal, J, 2023)	1.55
"Pre-treatment of sulforaphane (SFN), a known Nrf2 inducer, before serum starvation showed a protective effect via Nrf2/HO-1 upregulation."	( Sulforaphane ameliorates serum starvation-induced muscle atrophy via activation of the Nrf2 pathway in cultured C2C12 cells. Kim, DJ; Kim, HS; Moon, JY, 2020)	2.33
"Treatment with sulforaphane significantly increased viability to 77 ± 31%."	( Sulforaphane Protects Piglet Brains from Neonatal Hypoxic-Ischemic Injury. Koehler, RC; Kulikowicz, E; Lee, JK; Wang, B; Yang, ZJ, 2020)	2.34
"Treatment with sulforaphane or albumin resulted in the preservation of goblet cells (P < 0.03), reductions in histopathologic scores (P < 0.01), macrophage density (P < 0.01), iNOS expression (P < 0.004), NF-kappa B activation (P < 0.05), and apoptotic rates (P < 0.04) in the mucosa and a reduction in the concentration of lactic dehydrogenase (P < 0.04), more pronounced with sulforaphane."	( Sulforaphane and Albumin Attenuate Experimental Intestinal Ischemia-Reperfusion Injury. Bittencourt Rosas, SL; Dos Santos Valença, S; Franco, OB; Lima Castelo-Branco, MT; Lopes Lichtenberger, RC; Maran Carra, A; Pereira de Souza, HS; Ribeiro, BE; Sampaio de Holanda, G; Santana, PT; Schanaider, A, 2021)	2.4
"Treatment with sulforaphane (SFN), a diet-derived anticancer agent, reduces PRMT5/MEP50 level and H4R3me2s formation and suppresses the cancer phenotype."	( Sulforaphane inhibits PRMT5 and MEP50 function to suppress the mesothelioma cancer cell phenotype. Adhikary, G; Eckert, RL; Ezeka, G; Friedberg, JS; Kandasamy, S, 2021)	2.4
"Treatment with sulforaphane restored animals' body weight, reduced blood glucose, glycated hemoglobin, and increased insulin levels."	( Extracellular Matrix Remodeling and Modulation of Inflammation and Oxidative Stress by Sulforaphane in Experimental Diabetic Peripheral Neuropathy. Abdelkader, NF; El Awdan, SA; El-Shabrawy, OA; Moustafa, PE; Zaki, HF, 2018)	1.04
"Pretreatment with sulforaphane prevented OD-induced inflammation and AHR while increasing the uptake of OD in bronchial epithelial cells."	( Organic dust, causing both oxidative stress and Nrf2 activation, is phagocytized by bronchial epithelial cells. Adner, M; Chen, M; Farahnak, S; Larsson, K; Martin, JG; McGovern, T, 2019)	0.84
"Pre-treatment with sulforaphane inhibited TPA-stimulated NF-κB binding activity, but not AP-1 binding activity."	( Sulforaphane controls TPA-induced MMP-9 expression through the NF-κB signaling pathway, but not AP-1, in MCF-7 breast cancer cells. Chung, EY; Han, JH; Hwang, BM; Jung, SH; Kim, BS; Kim, JM; Kim, JS; Lee, SH; Lee, YR; Noh, EM; Youn, HJ, 2013)	2.15
"Pretreatment with sulforaphane significantly attenuated nuclear localization, DNA binding and the transcriptional activity of NF-κB through inhibition of phosphorylation and subsequent degradation of IκBα in MCF-10A cells stimulated with TPA."	( Sulforaphane inhibits phorbol ester-stimulated IKK-NF-κB signaling and COX-2 expression in human mammary epithelial cells by targeting NF-κB activating kinase and ERK. Cha, YN; Kim, DH; Kim, EH; Kim, HN; Kundu, JK; Lee, MH; Na, HK; Surh, YJ, 2014)	2.17
"Treatment with sulforaphane increased"	( Mechanisms of estrogen carcinogenesis: The role of E2/E1-quinone metabolites suggests new approaches to preventive intervention--A review. Yager, JD, 2015)	0.76
"Treatment with sulforaphane provided protection against a virulent H."	( Involvement of the electrophilic isothiocyanate sulforaphane in Arabidopsis local defense responses. Adolfsson, LE; Andersson, MX; Aronsson, H; Boztaş, G; Ellerström, M; Hamberg, M; Johansson, ON; Mackey, D; Nilsson, AK; Petit, CG; Pinosa, F; Tör, M, 2015)	1.01
"Treatment with sulforaphane inhibited hypoxia-induced vascular endothelial growth factor (VEGF) expression in HCT116 cells."	( Sulforaphane inhibits hypoxia-induced HIF-1α and VEGF expression and migration of human colon cancer cells. Hwang, SY; Im, E; Kang, YJ; Kim, DH; Kim, MJ; Kim, ND; Sung, B; Yoon, JH, 2015)	2.2
"Treatment with sulforaphane promotes microglia differentiation from pro-inflammatory M1 to anti-inflammatory M2 phenotype and reduces activation of astrocytes in hyperammonemic rats."	( Hyperammonemia induces glial activation, neuroinflammation and alters neurotransmitter receptors in hippocampus, impairing spatial learning: reversal by sulforaphane. Agustí, A; Cabrera-Pastor, A; Felipo, V; Hernández-Rabaza, V; Llansola, M; Malaguarnera, M; Taoro-González, L, 2016)	0.97
"Treatment with sulforaphane could be useful to improve cognitive function in cirrhotic patients with minimal or clinical hepatic encephalopathy."	( Hyperammonemia induces glial activation, neuroinflammation and alters neurotransmitter receptors in hippocampus, impairing spatial learning: reversal by sulforaphane. Agustí, A; Cabrera-Pastor, A; Felipo, V; Hernández-Rabaza, V; Llansola, M; Malaguarnera, M; Taoro-González, L, 2016)	0.97
"Pretreatment with sulforaphane (0.5, 1, and 5 microM) protected aortic smooth muscle cells from oxidative and electrophilic cytotoxicity induced by xanthine oxidase (XO)/xanthine, H2O2, SIN-1-derived peroxynitrite, 4-hydroxy-2-nonenal, and acrolein."	( Potent induction of total cellular and mitochondrial antioxidants and phase 2 enzymes by cruciferous sulforaphane in rat aortic smooth muscle cells: cytoprotection against oxidative and electrophilic stress. Ehrich, M; Jia, Z; Li, Y; Misra, HP; Strobl, JS; Zhu, H, 2008)	0.89
"Treatment with sulforaphane, a dietary antioxidant, activated Nrf2 and suppressed p38-VCAM-1 signaling at the susceptible site in wild-type but not Nrf2(-/-) animals, indicating that it suppresses EC activation via Nrf2."	( Activation of Nrf2 in endothelial cells protects arteries from exhibiting a proinflammatory state. Carlsen, H; Chaudhury, H; Cuhlmann, S; Edirisinghe, I; Evans, PC; Hamdulay, SS; Haskard, DO; Krams, R; Luong, le A; Mason, JC; Rahman, I; Van der Heiden, K; Zakkar, M, 2009)	0.69
"Treatment with sulforaphane inhibited an increase in the post-ischemic left ventricular end-diastolic pressure (LVEDP) and improved the post-ischemic left ventricular developed pressure (LVDP), +/-dP/dt, and coronary flow as compared with the untreated control hearts."	( Sulforaphane protects ischemic injury of hearts through antioxidant pathway and mitochondrial K(ATP) channels. Chae, HJ; Chae, SW; Gao, S; Kim, DS; Kim, SH; Lee, GH; Park, BH; Piao, CS, 2010)	2.14
"Pretreatment with sulforaphane and 6-HITC significantly protected against H(2)O(2)- and paraquat-induced cytotoxicity in a concentration-dependent manner."	( Glutathione biosynthesis via activation of the nuclear factor E2-related factor 2 (Nrf2)--antioxidant-response element (ARE) pathway is essential for neuroprotective effects of sulforaphane and 6-(methylsulfinyl) hexyl isothiocyanate. Akaike, A; Izumi, Y; Kume, T; Mizuno, K; Muto, C; Sugimoto, H; Takada-Takatori, Y, 2011)	0.89
"Treatment with sulforaphane, a small-molecule activator of the transcription factor nuclear factor erythroid 2-related factor 2 (NRF2), was also able to denitrosylate HDAC2, restoring dexamethasone sensitivity in alveolar macrophages from patients with COPD."	( Denitrosylation of HDAC2 by targeting Nrf2 restores glucocorticosteroid sensitivity in macrophages from COPD patients. Barnes, P; Biswal, S; Feller-Kopman, D; Ito, K; Kombairaju, P; Kumar, S; Ma, J; Malhotra, D; Mercado, N; Thimmulappa, RK; Wise, R, 2011)	0.71
"Treatment with sulforaphane (15 microM), PEITC (10 microM), indole-3-carbinol (10 microM) and 3,3'-diindolylmethane (10 microM) induced PARP cleavage after 24 and 48 h in both 40-16 and the 379.2 cell lines, suggestive of a p53-independent mechanism of apoptosis induction."	( Comparison of growth inhibition profiles and mechanisms of apoptosis induction in human colon cancer cell lines by isothiocyanates and indoles from Brassicaceae. Barillari, J; Bartsch, H; Gerhäuser, C; Iori, R; Lichtenberg, M; Pappa, G, 2006)	0.67
"Treatment with Sulforaphane along with the antigen, sheep red blood cells (SRBC), produced an enhancement in the circulating antibody titre and the number of plaque forming cells (PFC) in the spleen."	( Immunomodulatory activity of Sulforaphane, a naturally occurring isothiocyanate from broccoli (Brassica oleracea). Kuttan, G; Thejass, P, 2007)	0.97

Excerpt	Reference	Relevance
" The current work lays the groundwork for using Nrf2 activators for therapeutic and dietary interventions against adverse effects of arsenic."	( Nrf2 protects human bladder urothelial cells from arsenite and monomethylarsonous acid toxicity. Chen, W; Eblin, KE; Gandolfi, JA; Sun, Z; Wang, XJ; Zhang, DD, 2007)	0.34
" We investigated the protective effect of SFN against the toxic response of copper oxide (CuO) NPs in mouse embryonic fibroblasts (BALB 3T3)."	( Protective effect of sulphoraphane against oxidative stress mediated toxicity induced by CuO nanoparticles in mouse embryonic fibroblasts BALB 3T3. Ahamed, M; Akhtar, MJ; Alrokayan, SA; Fareed, M; Kumar, S, 2012)	0.38
" But, there have not yet any study about effects of sulforophane (SFN) and curcumin (CUR) on the oxidative stress created by acute toxic effects of malathion (MAL) as an OPI often causing human and animal poisoning."	( Effects of sulforophane and curcumin on oxidative stress created by acute malathion toxicity in rats. Alp, A; Alp, H; Aytekin, I; Hatipoglu, NK; Ogun, M, 2012)	0.38
" The results showed that triptolide caused oxidative stress and cell damage in HepG2 cells, and these toxic effects could be aggravated by Nrf2 knockdown or be counteracted by overexpression of Nrf2."	( Activation of Nrf2 protects against triptolide-induced hepatotoxicity. Fu, X; Guan, C; Huang, M; Huang, Z; Jin, J; Li, J; Shen, F; Sun, X; Wang, W, 2014)	0.4
" Previous studies have shown that oxidative stress caused by DOX is one of the primary mechanisms for its toxic effects on the heart."	( Sulforaphane protects the heart from doxorubicin-induced toxicity. Allen, CD; Beneš, H; McElhanon, K; Megyesi, JK; Sharma, R; Singh, P; Singh, SP, 2015)	1.86
"Transcription factor Nrf2 induces a number of detoxifying enzymes and antioxidant proteins to confer protection against the toxic effects of a diverse range of chemicals including inorganic arsenicals."	( Nrf2-dependent protection against acute sodium arsenite toxicity in zebrafish. Fuse, Y; Kobayashi, M; Nguyen, VT, 2016)	0.43
" Hence, objective of the current study was to investigate the potential toxic effects of ACS c-SLN combined chemopreventive regimens following acute (3 days), subacute (28 days), and subchronic (90 days) administrations by oral gavage in BALB/c mice."	( Preclinical systemic toxicity evaluation of chitosan-solid lipid nanoparticle-encapsulated aspirin and curcumin in combination with free sulforaphane in BALB/c mice. Chenreddy, S; Khamas, W; Prabhu, S; Thakkar, A; Thio, A; Wang, J, 2016)	0.64
"Cadmium (Cd) is a highly toxic and widely distributed heavy metal that induces various diseases in humans through environmental exposure."	( Sulforaphane mitigates cadmium-induced toxicity pattern in human peripheral blood lymphocytes and monocytes. Alkharashi, NAO; Alshatwi, AA; Athinarayanan, J; Periasamy, VS, 2017)	1.9
"Cd is a hazardous substance and carcinogen that is present in the environment; it is known to cause toxic effects in living organisms."	( Assessment of sulforaphane-induced protective mechanisms against cadmium toxicity in human mesenchymal stem cells. Alkharashi, NAO; Alshatwi, AA; Athinarayanan, J; Periasamy, VS, 2018)	0.84
"Epidemiological studies have demonstrated an association between ambient particulate pollution and adverse health effects in humans."	( Using Nrf2/antioxidant response element-dependent signaling to assess the toxicity potential of fly ash particles. Chen, Y; Tang, X; Wang, H; Wang, XJ; Zhang, J, 2019)	0.51
"Dose-dependent cardiotoxicity is the leading adverse reaction seen in cancer patients treated with doxorubicin."	( Attenuation of doxorubicin-induced cardiotoxicity in a human in vitro cardiac model by the induction of the NRF-2 pathway. Bentley, RA; Colley, HE; Copple, IM; Cross, MJ; Lu, ZQ; Murdoch, C; Sharma, P; Tomlinson, L; Webb, SD, 2019)	0.51
" Any adverse events will be recorded throughout the trial."	( The efficacy and safety of sulforaphane as an adjuvant in the treatment of bipolar depressive disorder: Study protocol for a randomized, double-blinded, placebo-controlled, parallel-group clinical trial. Chen, X; Hu, S; Lai, J; Wu, C; Xu, Y, 2020)	0.86
"Hexavalent chromium (Cr(vi)), the most toxic valence state of chromium, is widely present in industrial effluents and wastes."	( Sulforaphane attenuates hexavalent chromium-induced cardiotoxicity Baiyun, R; Han, B; Li, S; Liu, Y; Lv, Y; Lv, Z; Wang, X; Xue, J; Yang, D; Zhang, Z, 2020)	2
" The aim of this in silico investigation was to predict SFN-induced adverse effects in CRC patients by computational analysis."	( Predicting sulforaphane-induced adverse effects in colon cancer patients via in silico investigation. Antonijević, B; Baralić, K; Bozic, D; Bulat, Z; Ćurčić, M; Djordjević, AB; Miljaković, EA; Yang, L; Zhang, Y; Živančević, K; Đukić-Ćosić, D, 2022)	1.11
" The triple-negative breast cancer subtype therapies, due to the lack of specific drug targets, are still based on systemic chemotherapy with doxorubicin, which is burdened with severe adverse effects."	( Anticancer effect and safety of doxorubicin and nutraceutical sulforaphane liposomal formulation in triple-negative breast cancer (TNBC) animal model. Fronczyk, K; Mazur, M; Pogorzelska, A; Sigorski, D; Świtalska, M; Wietrzyk, J; Wiktorska, K, 2023)	1.15

Excerpt	Reference	Relevance
" An analytical method, utilising liquid chromatography-MS/MS, which allows the determination of sulforaphane in small volumes of rat plasma following exposure to low dietary doses, was developed and validated, and employed to determine its absolute bioavailability and pharmacokinetic characteristics."	( Absolute bioavailability and dose-dependent pharmacokinetic behaviour of dietary doses of the chemopreventive isothiocyanate sulforaphane in rat. Coldham, N; Gielbert, A; Hanlon, N; Ioannides, C; King, LJ; Kuhnert, N; Sauer, MJ, 2008)	0.77
" This novel LC-MS-MS method shows satisfactory accuracy and precision and is sufficiently sensitive for the performance of pharmacokinetic studies in rats."	( Development and validation of an LC-MS-MS method for the simultaneous determination of sulforaphane and its metabolites in rat plasma and its application in pharmacokinetic studies. Khor, TO; Kong, AN; Lin, W; Nomeir, AA; Shen, G; Wang, H, )	0.35
" SFN plasma concentration declined biexponentially and the pharmacokinetic parameters were generated."	( Pharmacokinetics and pharmacodynamics of phase II drug metabolizing/antioxidant enzymes gene response by anticancer agent sulforaphane in rat lymphocytes. Androulakis, IP; Huang, Y; Khor, TO; Kong, AN; Lin, W; Saw, CL; Wang, H; Wu, TY; Yang, Q, 2012)	0.59

Excerpt	Reference	Relevance
"Our previous studies have established the efficacy of chemopreventive regimens of aspirin and curcumin (CUR) encapsulated within solid lipid nanoparticles (SLNs) in combination with free sulforaphane (ACS combination) to prevent or delay the initiation and progression of pancreatic cancer, classified as one of the deadliest diseases with very low chances of survival upon diagnosis."	( Preclinical systemic toxicity evaluation of chitosan-solid lipid nanoparticle-encapsulated aspirin and curcumin in combination with free sulforaphane in BALB/c mice. Chenreddy, S; Khamas, W; Prabhu, S; Thakkar, A; Thio, A; Wang, J, 2016)	0.83
" The present study aims to test a dietary strategy, dietary supplementation with a high dose of vitamin D (VD) or its combination with sulforaphane (SFN) to inhibit intestinal inflammation and obesity-associated tumorigenesis."	( The Prevention of a High Dose of Vitamin D or Its Combination with Sulforaphane on Intestinal Inflammation and Tumorigenesis in Apc Frederick, AM; Guo, C; Jin, Y; Li, J; Liu, Z; Wood, RJ; Xiao, H, 2019)	0.95
"This study evaluated for the first time the feasibility of mild preheating treatment of broccoli florets combined with lactic acid bacteria fermentation for enhancing sulforaphane yield in broccoli puree."	( Mild heat combined with lactic acid fermentation: a novel approach for enhancing sulforaphane yield in broccoli puree. Augustin, MA; Cai, YX; Jegasothy, H; Terefe, NS; Wang, JH, 2020)	0.98

Excerpt	Reference	Relevance
" Results of this study indicate that the bioavailability of ITCs from fresh broccoli is approximately three times greater than that from cooked broccoli, in which myrosinase is inactivated."	( Disposition of glucosinolates and sulforaphane in humans after ingestion of steamed and fresh broccoli. Botero-Omary, M; Chung, FL; Conaway, CC; Getahun, SM; Liebes, LL; Pusateri, DJ; Topham, DK, 2000)	0.59
" An analytical method, utilising liquid chromatography-MS/MS, which allows the determination of sulforaphane in small volumes of rat plasma following exposure to low dietary doses, was developed and validated, and employed to determine its absolute bioavailability and pharmacokinetic characteristics."	( Absolute bioavailability and dose-dependent pharmacokinetic behaviour of dietary doses of the chemopreventive isothiocyanate sulforaphane in rat. Coldham, N; Gielbert, A; Hanlon, N; Ioannides, C; King, LJ; Kuhnert, N; Sauer, MJ, 2008)	0.77
" In humans, a key factor in determining the efficacy of SFN as a chemoprevention agent is gaining an understanding of the metabolism, distribution and bioavailability of SFN and the factors that alter these parameters."	( Multi-targeted prevention of cancer by sulforaphane. Clarke, JD; Dashwood, RH; Ho, E, 2008)	0.62
" Furthermore, these gene induction effects and the interaction with detoxification responses can modify bioavailability and in vivo bioactivity of drugs."	( Interaction of the isothiocyanate sulforaphane with drug disposition and metabolism: pharmacological and toxicological implications. Fimognari, C; Hrelia, P; Lenzi, M, 2008)	0.63
"The aim of this study was to determine the bioavailability and kinetics of the supposed anticarcinogen sulforaphane, the hydrolysis product of glucoraphanin, from raw and cooked broccoli."	( Bioavailability and kinetics of sulforaphane in humans after consumption of cooked versus raw broccoli. Klöpping-Ketelaars, IW; Vaes, WH; van den Berg, R; Vermeulen, M, 2008)	0.84
" Apart from the biological activity of SFN, this review also focuses on its bioavailability and tissue distribution as well as individuals' genetic predispositions as significant factors influencing the potential efficiency of chemoprevention using this compound."	( [Sulforaphane--a possible agent in prevention and therapy of cancer]. Olejnik, A; Tomczyk, J, 2010)	1.27
" Therefore, a cross-over clinical trial was undertaken to compare the bioavailability and tolerability of sulforaphane from two of broccoli sprout-derived beverages: one glucoraphanin-rich (GRR) and the other sulforaphane-rich (SFR)."	( Bioavailability of Sulforaphane from two broccoli sprout beverages: results of a short-term, cross-over clinical trial in Qidong, China. Botting, NP; Chen, JG; Chen, TY; Chen, YS; Egner, PA; Fahey, JW; Friesen, MD; Groopman, JD; Jacobson, LP; Kensler, TW; Lu, JH; Muñoz, A; Ng, D; Qian, GS; Sun, Y; Talalay, P; Wang, JB; Wu, Y; Zhang, Q; Zhang, YH; Zhu, J; Zhu, YR, 2011)	0.91
" The bioavailability and excretion of the mercapturic acid pathway metabolites isothiocyanates after human consumption of broccoli supplements has not been tested."	( Bioavailability and inter-conversion of sulforaphane and erucin in human subjects consuming broccoli sprouts or broccoli supplement in a cross-over study design. Bella, D; Clarke, JD; Ho, E; Hsu, A; Riedl, K; Schwartz, SJ; Stevens, JF, 2011)	0.64
" In a previous study, biomarkers of SF bioavailability from a powder rich in GRP, but lacking myrosinase, were enhanced by co-consumption of a myrosinase-containing air-dried broccoli sprout powder."	( Enhancing sulforaphane absorption and excretion in healthy men through the combined consumption of fresh broccoli sprouts and a glucoraphanin-rich powder. Cramer, JM; Jeffery, EH; Teran-Garcia, M, 2012)	0.78
" We compared the bioavailability and metabolism of sulforaphane from portions of lightly cooked fresh or frozen broccoli, and investigated the bioconversion of sulforaphane to erucin."	( Isothiocyanate concentrations and interconversion of sulforaphane to erucin in human subjects after consumption of commercial frozen broccoli compared to fresh broccoli. Barrett, DA; Hollands, W; Kroon, PA; Mithen, RF; Narbad, A; Needs, PW; Ortori, CA; Rossiter, JT; Saha, S; Teucher, B, 2012)	0.88
" Sulforaphane bioavailability was about tenfold higher for the soups made from fresh compared to frozen broccoli, and the reduction was shown to be due to destruction of myrosinase activity by the commercial blanching-freezing process."	( Isothiocyanate concentrations and interconversion of sulforaphane to erucin in human subjects after consumption of commercial frozen broccoli compared to fresh broccoli. Barrett, DA; Hollands, W; Kroon, PA; Mithen, RF; Narbad, A; Needs, PW; Ortori, CA; Rossiter, JT; Saha, S; Teucher, B, 2012)	1.54
" The analytical capacity of this novel method was further tested by determining the bioavailability of GR and its metabolic derivatives in urine from volunteers after the consumption of ½ and 1 servings of broccoli sprouts (30 and 60g, respectively)."	( A new ultra-rapid UHPLC/MS/MS method for assessing glucoraphanin and sulforaphane bioavailability in human urine. Dominguez-Perles, R; Ferreres, F; García-Viguera, C; Gil-Izquierdo, Á; Medina, S; Moreno, DÁ, 2014)	0.64
"For the first time, the effect of residual MYR activity on isothiocyanate bioavailability was systematically and quantitatively studied."	( In vivo formation and bioavailability of isothiocyanates from glucosinolates in broccoli as affected by processing conditions. Dekker, M; Oliviero, T; Verkerk, R; Vermeulen, M, 2014)	0.4
" Measures of sulforaphane metabolites in urine indicated that bioavailability did not decline over the 12-week daily dosing period."	( Rapid and sustainable detoxication of airborne pollutants by broccoli sprout beverage: results of a randomized clinical trial in China. Carmella, SG; Chen, JG; Chen, TY; Egner, PA; Fahey, JW; Groopman, JD; Hecht, SS; Jacobson, LP; Johnson, JL; Kensler, KH; Kensler, TW; Muñoz, A; Ng, DK; Qian, GS; Talalay, P; Wang, JB; Zarth, AT; Zhu, J, 2014)	0.77
" SFN bioavailability from dietary sources is a critical determinant of its efficacy in humans."	( Absorption and chemopreventive targets of sulforaphane in humans following consumption of broccoli sprouts or a myrosinase-treated broccoli sprout extract. Atwell, LL; Bella, D; Christensen, JM; Dashwood, RH; Ho, E; Hsu, A; Löhr, CV; Pereira, CB; Shannon, J; Stevens, JF; Williams, DE; Wong, CP; Yu, TW, 2015)	0.68
" We have focused upon evaluating the bioavailability of sulforaphane, either by direct administration of glucoraphanin (a glucosinolate, or β-thioglucoside-N-hydroxysulfate), or by co-administering glucoraphanin and the enzyme myrosinase to catalyze its conversion to sulforaphane at economic, reproducible and sustainable yields."	( Sulforaphane Bioavailability from Glucoraphanin-Rich Broccoli: Control by Active Endogenous Myrosinase. Fahey, JW; Holtzclaw, WD; Stephenson, KK; Talalay, P; Wade, KL; Wehage, SL, 2015)	2.11
" By virtue of its lipophilic nature and low molecular weight, sulforaphane displays significantly higher bioavailability than the polyphenol-based dietary supplements that also activate Nrf2."	( Sulforaphane and Other Nutrigenomic Nrf2 Activators: Can the Clinician's Expectation Be Matched by the Reality? Coombes, JS; Fassett, RG; Houghton, CA, 2016)	2.12
" A pilot clinical trial in 10 healthy volunteers evaluated the bioavailability and pharmacodynamic activity of three different BSE regimens, based upon urinary sulforaphane metabolites and NQO1 transcripts in buccal scrapings, respectively."	( Prevention of Carcinogen-Induced Oral Cancer by Sulforaphane. Bauman, JE; Egner, PA; Fahey, JW; Grandis, JR; Johnson, DE; Kensler, TW; Li, C; Normolle, DP; Sen, M; Wang, L; Zang, Y, 2016)	0.89
"We evaluated the stability and bioavailability of two stabilized SF preparations-an α-cyclodextrin inclusion (SF-αCD), and an SF-rich, commercial nutritional supplement."	( Stabilized sulforaphane for clinical use: Phytochemical delivery efficiency. Fahey, JW; Fuchs, E; Holtzclaw, WD; Liu, H; Stephenson, KK; Talalay, P; Wade, KL; Wehage, SL, 2017)	0.84
"The evaluation of the bioavailability of bioactive compounds from cruciferous foods is one challenge in the design of clinical trials for studying their functionality."	( Bioavailability and new biomarkers of cruciferous sprouts consumption. Baenas, N; García-Viguera, C; Moreno, DA; Suárez-Martínez, C, 2017)	0.46
" Metabolic profile, NO bioavailability and vascular oxidative stress, AGE and Nrf2 levels were also assessed."	( The Sulforaphane and pyridoxamine supplementation normalize endothelial dysfunction associated with type 2 diabetes. Crisóstomo, J; Fernandes, R; Pereira, A; Seiça, RM; Sena, CM, 2017)	1.01
"This is the first study to report the bioavailability of glucoraphanin and sulforaphane from soups made with novel broccoli varieties."	( Bioavailability of Glucoraphanin and Sulforaphane from High-Glucoraphanin Broccoli. Dainty, JR; Melchini, A; Mithen, RF; Needs, PW; Saha, S; Sivapalan, T; Tapp, H; Traka, MH, 2018)	0.98
" Bioavailability studies also suggest the contribution of SFN metabolites, including erucin (ERN), to the neuroprotective effects of SFN."	( Comparison of Adaptive Neuroprotective Mechanisms of Sulforaphane and its Interconversion Product Erucin in in Vitro and in Vivo Models of Parkinson's Disease. Cantelli-Forti, G; D'Amico, M; Djemil, A; Hrelia, P; Morroni, F; Pruccoli, L; Sita, G; Tarozzi, A, 2018)	0.73
" To allow comparison between rodent and human studies, we discuss the published bioavailability of SFN metabolites achieved in rodents and man in the context of Nrf2, NFκB and PPARγ signaling."	( Concerted redox modulation by sulforaphane alleviates diabetes and cardiometabolic syndrome. Chapple, SJ; Mann, GE; Patel, B, 2018)	0.77
"Optimization of bioavailability of dietary bioactive health-beneficial compounds is as important as increasing their concentration in foods."	( Bioavailability of Isothiocyanates From Broccoli Sprouts in Protein, Lipid, and Fiber Gels. Capuano, E; Dekker, M; Lamers, S; Oliviero, T; Verkerk, R, 2018)	0.48
" Samples in which sulforaphane and iberin were preformed by myrosinase led to a higher bioavailability of those compounds."	( Bioavailability of Isothiocyanates From Broccoli Sprouts in Protein, Lipid, and Fiber Gels. Capuano, E; Dekker, M; Lamers, S; Oliviero, T; Verkerk, R, 2018)	0.81
"This explorative study suggests that ITCs bioavailability can be modulated by food structure and composition and further and deeper investigations are needed to develop food products that lead to an optimized ITCs bioavailability."	( Bioavailability of Isothiocyanates From Broccoli Sprouts in Protein, Lipid, and Fiber Gels. Capuano, E; Dekker, M; Lamers, S; Oliviero, T; Verkerk, R, 2018)	0.48
"These results conclude that when powdered brown mustard is added to cooked broccoli, the bioavailability of sulforaphane is over four times greater than that from cooked broccoli ingested alone."	( Supplementation of the Diet by Exogenous Myrosinase via Mustard Seeds to Increase the Bioavailability of Sulforaphane in Healthy Human Subjects after the Consumption of Cooked Broccoli. Ghawi, SK; Kuhnle, G; Methven, L; Niranjan, K; Okunade, O, 2018)	0.91
" Multiple in vivo studies have shown the bioavailability of isothiocyanates and their antitumoral effects."	( Cruciferous Vegetables, Isothiocyanates, and Bladder Cancer Prevention. Abbaoui, B; Clinton, SK; Lucas, CR; Mortazavi, A; Riedl, KM, 2018)	0.48
" This review also highlights the importance of the nanoformulation of such bioactive phytochemicals that could enhance their bioavailability by providing an efficient targeted delivery system with a reduced systemic dose while resulting in a more efficient dosing at the target site."	( Combating breast cancer using combination therapy with 3 phytochemicals: Piperine, sulforaphane, and thymoquinone. Aumeeruddy, MZ; Mahomoodally, MF, 2019)	0.74
", plants, sprouts, beverages, supplements), bioavailability and efficacy, and the doses of glucoraphanin and/or sulforaphane that have been used in pre-clinical and clinical studies."	( Broccoli or Sulforaphane: Is It the Source or Dose That Matters? Dinkova-Kostova, AT; Fahey, JW; Kensler, TW; Yagishita, Y, 2019)	1.1
" To inform future clinical trials, we set out to determine the bioavailability of sulforaphane in non-pregnant and preeclamptic women."	( Sulforaphane Bioavailability and Effects on Blood Pressure in Women with Pregnancy Hypertension. Anderson, D; Creek, DJ; Langston-Cox, AG; Marshall, SA; Palmer, KR; Wallace, EM, 2021)	2.29
" Their stability, natural structure, composition, and bioavailability make them good candidates as drug vehicles."	( Sustained release of sulforaphane by bioactive extracellular vesicles for neuroprotective effect on chick model. Saeidifar, M; Shahlaei, M; Zamanian, A, 2022)	1.04
" Nrf2-ARE signaling pathway can be considered a promising target for novel therapies of epilepsy, particularly when new compounds, possessing inhibitory activity against protein-protein interaction between Nrf2 and its repressor protein Keap1, with less "off-target" effects and, importantly, with an optimal permeability and bioavailability properties, become available commercially."	( Protective Effect of Sulforaphane on Oxidative Stress and Mitochondrial Dysfunction Associated with Status Epilepticus in Immature Rats. Folbergrová, J; Ješina, P; Otáhal, J, 2023)	1.23

Excerpt	Relevance	Reference
" The corresponding figures in rats dosed with ERN were approximately 67% and approximately 29%."	( Biotransformation of the naturally occurring isothiocyanate sulforaphane in the rat: identification of phase I metabolites and glutathione conjugates. Baillie, T; Davis, M; Hu, P; Kassahun, K; Martin, B, 1997)	0.54
" SFN and PEITC and their NAC conjugates were administered by gavage either three times weekly for 8 weeks (5 and 20 micromol, respectively) after AOM dosing (post-initiation stage) or once daily for 3 days (20 and 50 micromol, respectively) before AOM treatment (initiation stage)."	( Chemoprevention of colonic aberrant crypt foci in Fischer rats by sulforaphane and phenethyl isothiocyanate. Chung, FL; Conaway, CC; Rao, CV; Reddy, BS, 2000)	0.54
" Northern blot indicated that sulforaphane increased MRP2 mRNA levels in primary rat hepatocytes; it also induced expression of drug metabolizing enzymes such as glutathione S-transferase A1/2 isoforms and NAD(P)H:quinone oxidoreductase in a dose-response and time-course manner similar to that observed for the upregulation of MRP2 transcripts."	( Reactive oxygen species-related induction of multidrug resistance-associated protein 2 expression in primary hepatocytes exposed to sulforaphane. Courtois, A; Fardel, O; Guillouzo, A; Loewert, M; Payen, L, 2001)	0.8
" These findings may have important implications for the development of an effective dosing regimen for SF."	( High cellular accumulation of sulphoraphane, a dietary anticarcinogen, is followed by rapid transporter-mediated export as a glutathione conjugate. Callaway, EC; Zhang, Y, 2002)	0.31
"05) reduced PCNA and elevated PARP fragmentation in samples from animals dosed with SUL."	( Sulforaphane: a naturally occurring mammary carcinoma mitotic inhibitor, which disrupts tubulin polymerization. Jackson, SJ; Singletary, KW, 2004)	1.77
"A self-aspirating, liquid microjunction surface sampling probe/electrospray emitter mass spectrometry system was demonstrated for use in the direct analysis of spotted and dosed drugs and their metabolites in thin tissue sections."	( Liquid microjunction surface sampling probe electrospray mass spectrometry for detection of drugs and metabolites in thin tissue sections. Kertesz, V; Koeplinger, KA; Kong, AN; Van Berkel, GJ; Vavrek, M, 2008)	0.35
"All subjects tolerated oral sulforaphane dosing without significant adverse events."	( Oral sulforaphane increases Phase II antioxidant enzymes in the human upper airway. Diaz-Sanchez, D; Riedl, MA; Saxon, A, 2009)	1.16
" Elimination rates were considerably slower with GRR, allowing for achievement of steady-state dosing as opposed to bolus dosing with SFR."	( Bioavailability of Sulforaphane from two broccoli sprout beverages: results of a short-term, cross-over clinical trial in Qidong, China. Botting, NP; Chen, JG; Chen, TY; Chen, YS; Egner, PA; Fahey, JW; Friesen, MD; Groopman, JD; Jacobson, LP; Kensler, TW; Lu, JH; Muñoz, A; Ng, D; Qian, GS; Sun, Y; Talalay, P; Wang, JB; Wu, Y; Zhang, Q; Zhang, YH; Zhu, J; Zhu, YR, 2011)	0.7
" Both effects increased in proportion to the dosage of SFN, and apoptosis was induced via mitochondria- and caspase-dependent pathways."	( Effect of sulforaphane on growth inhibition in human brain malignant glioma GBM 8401 cells by means of mitochondrial- and MEK/ERK-mediated apoptosis pathway. Chang, WC; Hsu, YC; Huang, TY; Wang, MY; Yang, YR, 2012)	0.78
"In vitro studies were used for the dose-response (AlamarBlue) effects of acetazolamide (AZ) and sulforaphane (SFN) on clonogenicity, serotonin-induced growth effect and serotonin content (LC-MS) on H-727 (TC) and H-720 (AC) bronchial carcinoid cell lines and their derived NOD/SCID mice subcutaneous xenografts."	( Combination of carbonic anhydrase inhibitor, acetazolamide, and sulforaphane, reduces the viability and growth of bronchial carcinoid cell lines. Adeli, K; Cutz, E; Islam, SS; Kumar, S; Mokhtari, RB; Yazdanpanah, M; Yeger, H, 2013)	0.85
" Measures of sulforaphane metabolites in urine indicated that bioavailability did not decline over the 12-week daily dosing period."	( Rapid and sustainable detoxication of airborne pollutants by broccoli sprout beverage: results of a randomized clinical trial in China. Carmella, SG; Chen, JG; Chen, TY; Egner, PA; Fahey, JW; Groopman, JD; Hecht, SS; Jacobson, LP; Johnson, JL; Kensler, KH; Kensler, TW; Muñoz, A; Ng, DK; Qian, GS; Talalay, P; Wang, JB; Zarth, AT; Zhu, J, 2014)	0.77
" We evaluated SFN absorption from a myrosinase-treated broccoli sprout extract (BSE) and are the first to report effects of twice daily, oral dosing on SFN exposure in healthy adults."	( Absorption and chemopreventive targets of sulforaphane in humans following consumption of broccoli sprouts or a myrosinase-treated broccoli sprout extract. Atwell, LL; Bella, D; Christensen, JM; Dashwood, RH; Ho, E; Hsu, A; Löhr, CV; Pereira, CB; Shannon, J; Stevens, JF; Williams, DE; Wong, CP; Yu, TW, 2015)	0.68
" Twelve-hour dosing retained higher plasma SFN metabolite levels at later time points than 24-hour dosing."	( Absorption and chemopreventive targets of sulforaphane in humans following consumption of broccoli sprouts or a myrosinase-treated broccoli sprout extract. Atwell, LL; Bella, D; Christensen, JM; Dashwood, RH; Ho, E; Hsu, A; Löhr, CV; Pereira, CB; Shannon, J; Stevens, JF; Williams, DE; Wong, CP; Yu, TW, 2015)	0.68
"We conclude that the dietary form and dosing schedule of SFN may impact SFN absorption and efficacy in human trials."	( Absorption and chemopreventive targets of sulforaphane in humans following consumption of broccoli sprouts or a myrosinase-treated broccoli sprout extract. Atwell, LL; Bella, D; Christensen, JM; Dashwood, RH; Ho, E; Hsu, A; Löhr, CV; Pereira, CB; Shannon, J; Stevens, JF; Williams, DE; Wong, CP; Yu, TW, 2015)	0.68
" Future studies employing larger sample sizes should evaluate alternative dosing and duration regimens to inform dietary SFN strategies in breast cancer chemoprevention."	( Sulforaphane Bioavailability and Chemopreventive Activity in Women Scheduled for Breast Biopsy. Atwell, LL; Farris, P; Ho, E; Mori, M; Naik, AM; Oh, KY; Shannon, J; Thuillier, P; Vetto, JT; Zhang, Z, 2015)	1.86
" Based on the results of this study, no signs of toxicity in acute, subacute, and subchronic studies following oral administration of ACS c-SLNs were found indicating that the oral dosing regimens were safe at the levels tested for long-term administration to prevent the onset of pancreatic cancer."	( Preclinical systemic toxicity evaluation of chitosan-solid lipid nanoparticle-encapsulated aspirin and curcumin in combination with free sulforaphane in BALB/c mice. Chenreddy, S; Khamas, W; Prabhu, S; Thakkar, A; Thio, A; Wang, J, 2016)	0.64
" In addition, the effects of GADD45β gene activation in cell cycle arrest increase proportionally with the dose of SFN; however, mitotic delay and the inhibition of proliferation both depend on the dosage of SFN used to treat cancer cells."	( Sulforaphane, a Dietary Isothiocyanate, Induces G₂/M Arrest in Cervical Cancer Cells through CyclinB1 Downregulation and GADD45β/CDC2 Association. Cheng, YM; Hsu, YC; Tsai, CC, 2016)	1.88
" Results of studies in a rat orthotopic breast cancer model indicated that SFN enhanced the efficacy of DOX in regression of tumor growth, and that the DOX dosage required to treat the tumor could be reduced when SFN was administered concomitantly."	( Sulforaphane potentiates anticancer effects of doxorubicin and attenuates its cardiotoxicity in a breast cancer model. Awasthi, S; Beneš, H; Boerma, M; Bose, C; Hauer-Jensen, M; Sharma, R; Singh, SP, 2018)	1.92
" This synergistic activity enables a considerable reduction in cytostatic dosage and an increase in cancer treatment efficiency."	( In the triple-negative breast cancer MDA-MB-231 cell line, sulforaphane enhances the intracellular accumulation and anticancer action of doxorubicin encapsulated in liposomes. Chilmonczyk, Z; Krug, P; Mazur, M; Mielczarek, L; Milczarek, M; Wiktorska, K, 2019)	0.76
" This review also highlights the importance of the nanoformulation of such bioactive phytochemicals that could enhance their bioavailability by providing an efficient targeted delivery system with a reduced systemic dose while resulting in a more efficient dosing at the target site."	( Combating breast cancer using combination therapy with 3 phytochemicals: Piperine, sulforaphane, and thymoquinone. Aumeeruddy, MZ; Mahomoodally, MF, 2019)	0.74
"MS was also used to quantify urinary sulforaphane metabolites in each dosing regimen that resulted in a median 24-h urinary output of 24."	( Dose-dependent detoxication of the airborne pollutant benzene in a randomized trial of broccoli sprout beverage in Qidong, China. Carmella, S; Chen, JG; Chen, YS; Egner, P; Fahey, J; Groopman, J; Hecht, S; Jacobson, L; Johnson, J; Kensler, K; Kensler, T; Lu, LL; Muñoz, A; Ng, D; Rule, A; Sun, Y; Wang, JB; Wu, Y; Xue, XF; Zhang, YH; Zhu, J; Zhu, YR, 2019)	0.79
"An intervention with a broccoli sprout beverage enhanced the detoxication of benzene, an important airborne pollutant, when dosed at a concentration evoking a urinary elimination of ∼25 µmol sulforaphane metabolites per day, and it portends a practical and frugal population-based strategy to attenuate associated long-term health risks of air pollution."	( Dose-dependent detoxication of the airborne pollutant benzene in a randomized trial of broccoli sprout beverage in Qidong, China. Carmella, S; Chen, JG; Chen, YS; Egner, P; Fahey, J; Groopman, J; Hecht, S; Jacobson, L; Johnson, J; Kensler, K; Kensler, T; Lu, LL; Muñoz, A; Ng, D; Rule, A; Sun, Y; Wang, JB; Wu, Y; Xue, XF; Zhang, YH; Zhu, J; Zhu, YR, 2019)	0.7
" Although SFN was broadly chemoprotective within an hormetic dose-response context, it also enhanced cell proliferation/cell viability at low concentrations in multiple tumor cell lines."	( The phytoprotective agent sulforaphane prevents inflammatory degenerative diseases and age-related pathologies via Nrf2-mediated hormesis. Calabrese, EJ; Kozumbo, WJ, 2021)	0.92
" Given our findings of the benefit of SFA/Broccoli Sprouts as a dietary supplement during pregnancy, with improvement to the fetus, it is important to determine the beneficial and toxic dosing range of SFA."	( Sulforaphane (SFA) protects neuronal cells from oxygen & glucose deprivation (OGD). Armstrong, EA; Garcia, E; Ladak, Z; Landry, T; Persad, S; Yager, JY; Yoon, J, 2021)	2.06
" Because the fetus is a rapidly growing organism with profound cell multiplication, dosing parameters must be established to insure safety within efficacious ranges."	( Sulforaphane (SFA) protects neuronal cells from oxygen & glucose deprivation (OGD). Armstrong, EA; Garcia, E; Ladak, Z; Landry, T; Persad, S; Yager, JY; Yoon, J, 2021)	2.06
" However, species, disease model, duration, SFN dosage as well as route of administration did not explain the heterogeneity among studies."	( Sulforaphane ameliorates lipid profile in rodents: an updated systematic review and meta-analysis. Du, K; Fan, Y; Li, D, 2021)	2.06
" Surprisingly, oral dosing of both compounds suppressed scratching behaviors that were observed in mice."	( Anti-pruritic effect of isothiocyanates: Potential involvement of toll-like receptor 3 signaling. Hayashi, I; Kainoh, M; Konno, M; Majima, Y; Moriyama, M; Serizawa, K; Suzuki, T; Yuzawa, N, 2022)	0.72

Product Category	Products
Professional Supplements	2
Vitamins & Supplements	1

Product	Brand	Category	Compounds Matched from Ingredients	Date Retrieved
Double Wood Supplements Sulforaphane -- 20 mg - 120 Capsules	Double Wood Supplements	Professional Supplements	Sulforaphane	2024-11-29 10:47:42
Dr. Mercola Fermented Broccoli Sprouts -- 30 Capsules	Dr. Mercola	Professional Supplements	Glucoraphanin, Sulforaphane	2024-11-29 10:47:42
Natural Factors WomenSense EstroSense® -- 60 Vegetarian Capsules	Natural Factors	Vitamins & Supplements	Di-Indolylmethane, Curcumin, Microcrystalline cellulose, Indole-3-Carbinol, Lycopene, Carnosic Acid, Sulforaphane	2024-11-29 10:47:42

Role	Description
antineoplastic agent	A substance that inhibits or prevents the proliferation of neoplasms.
plant metabolite	Any eukaryotic metabolite produced during a metabolic reaction in plants, the kingdom that include flowering plants, conifers and other gymnosperms.
antioxidant	A substance that opposes oxidation or inhibits reactions brought about by dioxygen or peroxides.
EC 3.5.1.98 (histone deacetylase) inhibitor	An EC 3.5.1.* (non-peptide linear amide C-N hydrolase) inhibitor that interferes with the function of histone deacetylase (EC 3.5.1.98).
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Class	Description
sulfoxide	An organosulfur compound having the structure R2S=O or R2C=S=O (R =/= H).
isothiocyanate	An organosulfur compound with the general formula R-N=C=S.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Pathway	Proteins	Compounds
Transcriptional activation by Nfe2l2 in response to phytochemicals	0	2
Transcriptional activation by NRF2	0	3
Transcriptional activation by NRF2 in response to phytochemicals	0	3

Protein	Taxonomy	Measurement	Average	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
Epidermal growth factor receptor	Homo sapiens (human)	IC50 (µMol)	9.0000	0.0000	0.5369	10.0000	AID1303332
Macrophage migration inhibitory factor	Homo sapiens (human)	IC50 (µMol)	6.6000	0.0380	3.0910	9.8000	AID1198787; AID1198788
Nitric oxide synthase, inducible	Mus musculus (house mouse)	IC50 (µMol)	0.4000	0.0010	3.3911	9.6000	AID1226966
Kelch-like ECH-associated protein 1	Homo sapiens (human)	IC50 (µMol)	100.0000	0.7920	1.7980	3.0000	AID1536346
Nuclear factor erythroid 2-related factor 2	Homo sapiens (human)	IC50 (µMol)	100.0000	0.0292	1.7764	3.0000	AID1536346
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Protein	Taxonomy	Measurement	Average	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
Kelch-like ECH-associated protein 1	Homo sapiens (human)	EC50 (µMol)	0.8700	0.8700	2.7600	5.1100	AID1519148
Kelch-like ECH-associated protein 1	Homo sapiens (human)	Kd	10.0000	1.0000	1.7667	2.4000	AID1765438
Nuclear factor erythroid 2-related factor 2	Homo sapiens (human)	EC50 (µMol)	4.4620	0.0600	2.6167	9.9000	AID1339465; AID1510919; AID1519148; AID1534949; AID773885
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Protein	Taxonomy	Measurement	Average	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
NAD	Homo sapiens (human)	CD	0.2100	0.0100	0.0773	0.2100	AID490158
Delta-type opioid receptor	Rattus norvegicus (Norway rat)	CD	0.4300	0.4300	4.6150	8.8000	AID334057
Quinone oxidoreductase	Mus musculus (house mouse)	Activity	0.3733	0.0230	1.9024	9.9100	AID380748; AID380757; AID380760
Quinone oxidoreductase	Mus musculus (house mouse)	CD	0.3879	0.2000	2.7421	9.8000	AID163303; AID334057; AID334281; AID355763; AID356303; AID356395; AID436295
Nuclear factor erythroid 2-related factor 2	Homo sapiens (human)	CD	0.8900	0.5400	1.1533	1.6800	AID1736435; AID1826670
Nuclear factor erythroid 2-related factor 2	Mus musculus (house mouse)	CD	0.2500	0.0009	0.1258	0.3000	AID1226965; AID1248053
NAD(P)H dehydrogenase [quinone] 1	Mus musculus (house mouse)	CD	0.3475	0.0002	0.2389	2.6500	AID1243385; AID1713569; AID417740; AID605649
Kelch-like ECH-associated protein 1	Mus musculus (house mouse)	CD	0.2000	0.0009	0.0677	0.2000	AID1226965
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Process	via Protein(s)	Taxonomy
negative regulation of transcription by RNA polymerase II	Transcription regulator protein BACH1	Homo sapiens (human)
DNA repair	Transcription regulator protein BACH1	Homo sapiens (human)
regulation of DNA-templated transcription	Transcription regulator protein BACH1	Homo sapiens (human)
regulation of transcription by RNA polymerase II	Transcription regulator protein BACH1	Homo sapiens (human)
regulation of metabolic process	Transcription regulator protein BACH1	Homo sapiens (human)
positive regulation of transcription by RNA polymerase II	Transcription regulator protein BACH1	Homo sapiens (human)
negative regulation of transcription by RNA polymerase II	Transcription factor MafK	Homo sapiens (human)
regulation of transcription by RNA polymerase II	Transcription factor MafK	Homo sapiens (human)
cell surface receptor signaling pathway	Epidermal growth factor receptor	Homo sapiens (human)
epidermal growth factor receptor signaling pathway	Epidermal growth factor receptor	Homo sapiens (human)
positive regulation of cell population proliferation	Epidermal growth factor receptor	Homo sapiens (human)
MAPK cascade	Epidermal growth factor receptor	Homo sapiens (human)
ossification	Epidermal growth factor receptor	Homo sapiens (human)
embryonic placenta development	Epidermal growth factor receptor	Homo sapiens (human)
positive regulation of protein phosphorylation	Epidermal growth factor receptor	Homo sapiens (human)
hair follicle development	Epidermal growth factor receptor	Homo sapiens (human)
translation	Epidermal growth factor receptor	Homo sapiens (human)
signal transduction	Epidermal growth factor receptor	Homo sapiens (human)
epidermal growth factor receptor signaling pathway	Epidermal growth factor receptor	Homo sapiens (human)
activation of phospholipase C activity	Epidermal growth factor receptor	Homo sapiens (human)
salivary gland morphogenesis	Epidermal growth factor receptor	Homo sapiens (human)
midgut development	Epidermal growth factor receptor	Homo sapiens (human)
learning or memory	Epidermal growth factor receptor	Homo sapiens (human)
circadian rhythm	Epidermal growth factor receptor	Homo sapiens (human)
positive regulation of cell population proliferation	Epidermal growth factor receptor	Homo sapiens (human)
diterpenoid metabolic process	Epidermal growth factor receptor	Homo sapiens (human)
peptidyl-tyrosine phosphorylation	Epidermal growth factor receptor	Homo sapiens (human)
cerebral cortex cell migration	Epidermal growth factor receptor	Homo sapiens (human)
positive regulation of cell growth	Epidermal growth factor receptor	Homo sapiens (human)
lung development	Epidermal growth factor receptor	Homo sapiens (human)
positive regulation of cell migration	Epidermal growth factor receptor	Homo sapiens (human)
positive regulation of superoxide anion generation	Epidermal growth factor receptor	Homo sapiens (human)
positive regulation of peptidyl-serine phosphorylation	Epidermal growth factor receptor	Homo sapiens (human)
response to cobalamin	Epidermal growth factor receptor	Homo sapiens (human)
response to hydroxyisoflavone	Epidermal growth factor receptor	Homo sapiens (human)
cellular response to reactive oxygen species	Epidermal growth factor receptor	Homo sapiens (human)
peptidyl-tyrosine autophosphorylation	Epidermal growth factor receptor	Homo sapiens (human)
ERBB2-EGFR signaling pathway	Epidermal growth factor receptor	Homo sapiens (human)
negative regulation of epidermal growth factor receptor signaling pathway	Epidermal growth factor receptor	Homo sapiens (human)
negative regulation of protein catabolic process	Epidermal growth factor receptor	Homo sapiens (human)
vasodilation	Epidermal growth factor receptor	Homo sapiens (human)
positive regulation of phosphorylation	Epidermal growth factor receptor	Homo sapiens (human)
ovulation cycle	Epidermal growth factor receptor	Homo sapiens (human)
hydrogen peroxide metabolic process	Epidermal growth factor receptor	Homo sapiens (human)
negative regulation of apoptotic process	Epidermal growth factor receptor	Homo sapiens (human)
positive regulation of MAP kinase activity	Epidermal growth factor receptor	Homo sapiens (human)
tongue development	Epidermal growth factor receptor	Homo sapiens (human)
positive regulation of cyclin-dependent protein serine/threonine kinase activity	Epidermal growth factor receptor	Homo sapiens (human)
positive regulation of DNA repair	Epidermal growth factor receptor	Homo sapiens (human)
positive regulation of DNA replication	Epidermal growth factor receptor	Homo sapiens (human)
positive regulation of bone resorption	Epidermal growth factor receptor	Homo sapiens (human)
positive regulation of DNA-templated transcription	Epidermal growth factor receptor	Homo sapiens (human)
positive regulation of vasoconstriction	Epidermal growth factor receptor	Homo sapiens (human)
negative regulation of mitotic cell cycle	Epidermal growth factor receptor	Homo sapiens (human)
positive regulation of transcription by RNA polymerase II	Epidermal growth factor receptor	Homo sapiens (human)
regulation of JNK cascade	Epidermal growth factor receptor	Homo sapiens (human)
symbiont entry into host cell	Epidermal growth factor receptor	Homo sapiens (human)
protein autophosphorylation	Epidermal growth factor receptor	Homo sapiens (human)
astrocyte activation	Epidermal growth factor receptor	Homo sapiens (human)
positive regulation of fibroblast proliferation	Epidermal growth factor receptor	Homo sapiens (human)
digestive tract morphogenesis	Epidermal growth factor receptor	Homo sapiens (human)
positive regulation of smooth muscle cell proliferation	Epidermal growth factor receptor	Homo sapiens (human)
neuron projection morphogenesis	Epidermal growth factor receptor	Homo sapiens (human)
epithelial cell proliferation	Epidermal growth factor receptor	Homo sapiens (human)
positive regulation of epithelial cell proliferation	Epidermal growth factor receptor	Homo sapiens (human)
regulation of peptidyl-tyrosine phosphorylation	Epidermal growth factor receptor	Homo sapiens (human)
protein insertion into membrane	Epidermal growth factor receptor	Homo sapiens (human)
response to calcium ion	Epidermal growth factor receptor	Homo sapiens (human)
regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	Epidermal growth factor receptor	Homo sapiens (human)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	Epidermal growth factor receptor	Homo sapiens (human)
positive regulation of synaptic transmission, glutamatergic	Epidermal growth factor receptor	Homo sapiens (human)
positive regulation of glial cell proliferation	Epidermal growth factor receptor	Homo sapiens (human)
morphogenesis of an epithelial fold	Epidermal growth factor receptor	Homo sapiens (human)
eyelid development in camera-type eye	Epidermal growth factor receptor	Homo sapiens (human)
response to UV-A	Epidermal growth factor receptor	Homo sapiens (human)
positive regulation of mucus secretion	Epidermal growth factor receptor	Homo sapiens (human)
regulation of ERK1 and ERK2 cascade	Epidermal growth factor receptor	Homo sapiens (human)
positive regulation of ERK1 and ERK2 cascade	Epidermal growth factor receptor	Homo sapiens (human)
cellular response to amino acid stimulus	Epidermal growth factor receptor	Homo sapiens (human)
cellular response to mechanical stimulus	Epidermal growth factor receptor	Homo sapiens (human)
cellular response to cadmium ion	Epidermal growth factor receptor	Homo sapiens (human)
cellular response to epidermal growth factor stimulus	Epidermal growth factor receptor	Homo sapiens (human)
cellular response to estradiol stimulus	Epidermal growth factor receptor	Homo sapiens (human)
cellular response to xenobiotic stimulus	Epidermal growth factor receptor	Homo sapiens (human)
cellular response to dexamethasone stimulus	Epidermal growth factor receptor	Homo sapiens (human)
positive regulation of canonical Wnt signaling pathway	Epidermal growth factor receptor	Homo sapiens (human)
liver regeneration	Epidermal growth factor receptor	Homo sapiens (human)
cell-cell adhesion	Epidermal growth factor receptor	Homo sapiens (human)
positive regulation of protein kinase C activity	Epidermal growth factor receptor	Homo sapiens (human)
positive regulation of G1/S transition of mitotic cell cycle	Epidermal growth factor receptor	Homo sapiens (human)
positive regulation of non-canonical NF-kappaB signal transduction	Epidermal growth factor receptor	Homo sapiens (human)
positive regulation of prolactin secretion	Epidermal growth factor receptor	Homo sapiens (human)
positive regulation of miRNA transcription	Epidermal growth factor receptor	Homo sapiens (human)
positive regulation of protein localization to plasma membrane	Epidermal growth factor receptor	Homo sapiens (human)
negative regulation of cardiocyte differentiation	Epidermal growth factor receptor	Homo sapiens (human)
neurogenesis	Epidermal growth factor receptor	Homo sapiens (human)
multicellular organism development	Epidermal growth factor receptor	Homo sapiens (human)
positive regulation of kinase activity	Epidermal growth factor receptor	Homo sapiens (human)
cell surface receptor protein tyrosine kinase signaling pathway	Epidermal growth factor receptor	Homo sapiens (human)
prostaglandin biosynthetic process	Macrophage migration inhibitory factor	Homo sapiens (human)
positive regulation of cytokine production	Macrophage migration inhibitory factor	Homo sapiens (human)
negative regulation of mature B cell apoptotic process	Macrophage migration inhibitory factor	Homo sapiens (human)
inflammatory response	Macrophage migration inhibitory factor	Homo sapiens (human)
cell surface receptor signaling pathway	Macrophage migration inhibitory factor	Homo sapiens (human)
positive regulation of cell population proliferation	Macrophage migration inhibitory factor	Homo sapiens (human)
negative regulation of gene expression	Macrophage migration inhibitory factor	Homo sapiens (human)
positive regulation of protein kinase A signaling	Macrophage migration inhibitory factor	Homo sapiens (human)
negative regulation of macrophage chemotaxis	Macrophage migration inhibitory factor	Homo sapiens (human)
carboxylic acid metabolic process	Macrophage migration inhibitory factor	Homo sapiens (human)
DNA damage response, signal transduction by p53 class mediator	Macrophage migration inhibitory factor	Homo sapiens (human)
negative regulation of cell migration	Macrophage migration inhibitory factor	Homo sapiens (human)
positive regulation of B cell proliferation	Macrophage migration inhibitory factor	Homo sapiens (human)
positive regulation of lipopolysaccharide-mediated signaling pathway	Macrophage migration inhibitory factor	Homo sapiens (human)
positive regulation of tumor necrosis factor production	Macrophage migration inhibitory factor	Homo sapiens (human)
negative regulation of myeloid cell apoptotic process	Macrophage migration inhibitory factor	Homo sapiens (human)
positive regulation of peptidyl-serine phosphorylation	Macrophage migration inhibitory factor	Homo sapiens (human)
positive regulation of phosphorylation	Macrophage migration inhibitory factor	Homo sapiens (human)
regulation of macrophage activation	Macrophage migration inhibitory factor	Homo sapiens (human)
negative regulation of apoptotic process	Macrophage migration inhibitory factor	Homo sapiens (human)
negative regulation of DNA damage response, signal transduction by p53 class mediator	Macrophage migration inhibitory factor	Homo sapiens (human)
innate immune response	Macrophage migration inhibitory factor	Homo sapiens (human)
positive regulation of fibroblast proliferation	Macrophage migration inhibitory factor	Homo sapiens (human)
positive regulation of peptidyl-tyrosine phosphorylation	Macrophage migration inhibitory factor	Homo sapiens (human)
positive chemotaxis	Macrophage migration inhibitory factor	Homo sapiens (human)
negative regulation of protein metabolic process	Macrophage migration inhibitory factor	Homo sapiens (human)
positive regulation of prostaglandin secretion involved in immune response	Macrophage migration inhibitory factor	Homo sapiens (human)
positive regulation of myeloid leukocyte cytokine production involved in immune response	Macrophage migration inhibitory factor	Homo sapiens (human)
protein homotrimerization	Macrophage migration inhibitory factor	Homo sapiens (human)
positive regulation of ERK1 and ERK2 cascade	Macrophage migration inhibitory factor	Homo sapiens (human)
positive regulation of arachidonic acid secretion	Macrophage migration inhibitory factor	Homo sapiens (human)
cellular senescence	Macrophage migration inhibitory factor	Homo sapiens (human)
negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	Macrophage migration inhibitory factor	Homo sapiens (human)
positive regulation of chemokine (C-X-C motif) ligand 2 production	Macrophage migration inhibitory factor	Homo sapiens (human)
negative regulation of cellular senescence	Macrophage migration inhibitory factor	Homo sapiens (human)
protein polyubiquitination	NAD	Homo sapiens (human)
response to ischemia	NAD	Homo sapiens (human)
NADH oxidation	NAD	Homo sapiens (human)
ubiquinone metabolic process	NAD	Homo sapiens (human)
xenobiotic metabolic process	NAD	Homo sapiens (human)
nitric oxide biosynthetic process	NAD	Homo sapiens (human)
response to oxidative stress	NAD	Homo sapiens (human)
synaptic transmission, cholinergic	NAD	Homo sapiens (human)
response to nutrient	NAD	Homo sapiens (human)
response to toxic substance	NAD	Homo sapiens (human)
response to hormone	NAD	Homo sapiens (human)
response to carbohydrate	NAD	Homo sapiens (human)
response to amine	NAD	Homo sapiens (human)
removal of superoxide radicals	NAD	Homo sapiens (human)
protein catabolic process	NAD	Homo sapiens (human)
response to estradiol	NAD	Homo sapiens (human)
response to lipopolysaccharide	NAD	Homo sapiens (human)
response to testosterone	NAD	Homo sapiens (human)
cellular response to oxidative stress	NAD	Homo sapiens (human)
negative regulation of protein catabolic process	NAD	Homo sapiens (human)
vitamin E metabolic process	NAD	Homo sapiens (human)
vitamin K metabolic process	NAD	Homo sapiens (human)
negative regulation of apoptotic process	NAD	Homo sapiens (human)
response to alkaloid	NAD	Homo sapiens (human)
positive regulation of neuron apoptotic process	NAD	Homo sapiens (human)
innate immune response	NAD	Homo sapiens (human)
cell redox homeostasis	NAD	Homo sapiens (human)
response to ethanol	NAD	Homo sapiens (human)
response to electrical stimulus	NAD	Homo sapiens (human)
cellular response to hydrogen peroxide	NAD	Homo sapiens (human)
NADPH oxidation	NAD	Homo sapiens (human)
cellular response to metal ion	NAD	Homo sapiens (human)
negative regulation of ferroptosis	NAD	Homo sapiens (human)
response to tetrachloromethane	NAD	Homo sapiens (human)
response to L-glutamine	NAD	Homo sapiens (human)
response to hydrogen sulfide	NAD	Homo sapiens (human)
response to flavonoid	NAD	Homo sapiens (human)
in utero embryonic development	Kelch-like ECH-associated protein 1	Homo sapiens (human)
ubiquitin-dependent protein catabolic process	Kelch-like ECH-associated protein 1	Homo sapiens (human)
regulation of autophagy	Kelch-like ECH-associated protein 1	Homo sapiens (human)
protein ubiquitination	Kelch-like ECH-associated protein 1	Homo sapiens (human)
positive regulation of proteasomal ubiquitin-dependent protein catabolic process	Kelch-like ECH-associated protein 1	Homo sapiens (human)
cellular response to oxidative stress	Kelch-like ECH-associated protein 1	Homo sapiens (human)
negative regulation of DNA-binding transcription factor activity	Kelch-like ECH-associated protein 1	Homo sapiens (human)
regulation of epidermal cell differentiation	Kelch-like ECH-associated protein 1	Homo sapiens (human)
cellular response to interleukin-4	Kelch-like ECH-associated protein 1	Homo sapiens (human)
negative regulation of response to oxidative stress	Kelch-like ECH-associated protein 1	Homo sapiens (human)
response to ischemia	Nuclear factor erythroid 2-related factor 2	Homo sapiens (human)
regulation of transcription by RNA polymerase II	Nuclear factor erythroid 2-related factor 2	Homo sapiens (human)
inflammatory response	Nuclear factor erythroid 2-related factor 2	Homo sapiens (human)
response to oxidative stress	Nuclear factor erythroid 2-related factor 2	Homo sapiens (human)
proteasomal ubiquitin-independent protein catabolic process	Nuclear factor erythroid 2-related factor 2	Homo sapiens (human)
positive regulation of gene expression	Nuclear factor erythroid 2-related factor 2	Homo sapiens (human)
negative regulation of cardiac muscle cell apoptotic process	Nuclear factor erythroid 2-related factor 2	Homo sapiens (human)
positive regulation of neuron projection development	Nuclear factor erythroid 2-related factor 2	Homo sapiens (human)
protein ubiquitination	Nuclear factor erythroid 2-related factor 2	Homo sapiens (human)
positive regulation of blood coagulation	Nuclear factor erythroid 2-related factor 2	Homo sapiens (human)
endoplasmic reticulum unfolded protein response	Nuclear factor erythroid 2-related factor 2	Homo sapiens (human)
cellular response to oxidative stress	Nuclear factor erythroid 2-related factor 2	Homo sapiens (human)
PERK-mediated unfolded protein response	Nuclear factor erythroid 2-related factor 2	Homo sapiens (human)
cellular response to glucose starvation	Nuclear factor erythroid 2-related factor 2	Homo sapiens (human)
proteasome-mediated ubiquitin-dependent protein catabolic process	Nuclear factor erythroid 2-related factor 2	Homo sapiens (human)
positive regulation of blood vessel endothelial cell migration	Nuclear factor erythroid 2-related factor 2	Homo sapiens (human)
regulation of innate immune response	Nuclear factor erythroid 2-related factor 2	Homo sapiens (human)
cell redox homeostasis	Nuclear factor erythroid 2-related factor 2	Homo sapiens (human)
positive regulation of angiogenesis	Nuclear factor erythroid 2-related factor 2	Homo sapiens (human)
positive regulation of DNA-templated transcription	Nuclear factor erythroid 2-related factor 2	Homo sapiens (human)
positive regulation of transcription by RNA polymerase II	Nuclear factor erythroid 2-related factor 2	Homo sapiens (human)
regulation of embryonic development	Nuclear factor erythroid 2-related factor 2	Homo sapiens (human)
aflatoxin catabolic process	Nuclear factor erythroid 2-related factor 2	Homo sapiens (human)
positive regulation of glucose import	Nuclear factor erythroid 2-related factor 2	Homo sapiens (human)
cellular response to hydrogen peroxide	Nuclear factor erythroid 2-related factor 2	Homo sapiens (human)
cellular response to copper ion	Nuclear factor erythroid 2-related factor 2	Homo sapiens (human)
cellular response to tumor necrosis factor	Nuclear factor erythroid 2-related factor 2	Homo sapiens (human)
cellular response to hypoxia	Nuclear factor erythroid 2-related factor 2	Homo sapiens (human)
cellular response to xenobiotic stimulus	Nuclear factor erythroid 2-related factor 2	Homo sapiens (human)
cellular response to fluid shear stress	Nuclear factor erythroid 2-related factor 2	Homo sapiens (human)
cellular response to laminar fluid shear stress	Nuclear factor erythroid 2-related factor 2	Homo sapiens (human)
negative regulation of ferroptosis	Nuclear factor erythroid 2-related factor 2	Homo sapiens (human)
integrated stress response signaling	Nuclear factor erythroid 2-related factor 2	Homo sapiens (human)
negative regulation of cellular response to hypoxia	Nuclear factor erythroid 2-related factor 2	Homo sapiens (human)
regulation of cellular response to oxidative stress	Nuclear factor erythroid 2-related factor 2	Homo sapiens (human)
negative regulation of hematopoietic stem cell differentiation	Nuclear factor erythroid 2-related factor 2	Homo sapiens (human)
negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway	Nuclear factor erythroid 2-related factor 2	Homo sapiens (human)
positive regulation of glutathione biosynthetic process	Nuclear factor erythroid 2-related factor 2	Homo sapiens (human)
positive regulation of ERAD pathway	Nuclear factor erythroid 2-related factor 2	Homo sapiens (human)
cellular response to angiotensin	Nuclear factor erythroid 2-related factor 2	Homo sapiens (human)
negative regulation of vascular associated smooth muscle cell migration	Nuclear factor erythroid 2-related factor 2	Homo sapiens (human)
positive regulation of ubiquitin-dependent protein catabolic process	Nuclear factor erythroid 2-related factor 2	Homo sapiens (human)
regulation of removal of superoxide radicals	Nuclear factor erythroid 2-related factor 2	Homo sapiens (human)
negative regulation of endothelial cell apoptotic process	Nuclear factor erythroid 2-related factor 2	Homo sapiens (human)
positive regulation of reactive oxygen species metabolic process	Nuclear factor erythroid 2-related factor 2	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Process	via Protein(s)	Taxonomy
DNA-binding transcription factor activity, RNA polymerase II-specific	Transcription regulator protein BACH1	Homo sapiens (human)
DNA-binding transcription repressor activity, RNA polymerase II-specific	Transcription regulator protein BACH1	Homo sapiens (human)
DNA-binding transcription activator activity, RNA polymerase II-specific	Transcription regulator protein BACH1	Homo sapiens (human)
DNA-binding transcription factor activity	Transcription regulator protein BACH1	Homo sapiens (human)
protein binding	Transcription regulator protein BACH1	Homo sapiens (human)
heme binding	Transcription regulator protein BACH1	Homo sapiens (human)
ligand-activated transcription factor activity	Transcription regulator protein BACH1	Homo sapiens (human)
RNA polymerase II cis-regulatory region sequence-specific DNA binding	Transcription regulator protein BACH1	Homo sapiens (human)
transcription cis-regulatory region binding	Transcription factor MafK	Homo sapiens (human)
DNA-binding transcription factor activity, RNA polymerase II-specific	Transcription factor MafK	Homo sapiens (human)
DNA-binding transcription repressor activity, RNA polymerase II-specific	Transcription factor MafK	Homo sapiens (human)
DNA-binding transcription factor activity	Transcription factor MafK	Homo sapiens (human)
protein binding	Transcription factor MafK	Homo sapiens (human)
sequence-specific DNA binding	Transcription factor MafK	Homo sapiens (human)
RNA polymerase II cis-regulatory region sequence-specific DNA binding	Transcription factor MafK	Homo sapiens (human)
epidermal growth factor receptor activity	Epidermal growth factor receptor	Homo sapiens (human)
virus receptor activity	Epidermal growth factor receptor	Homo sapiens (human)
chromatin binding	Epidermal growth factor receptor	Homo sapiens (human)
double-stranded DNA binding	Epidermal growth factor receptor	Homo sapiens (human)
MAP kinase kinase kinase activity	Epidermal growth factor receptor	Homo sapiens (human)
protein tyrosine kinase activity	Epidermal growth factor receptor	Homo sapiens (human)
transmembrane receptor protein tyrosine kinase activity	Epidermal growth factor receptor	Homo sapiens (human)
transmembrane signaling receptor activity	Epidermal growth factor receptor	Homo sapiens (human)
epidermal growth factor receptor activity	Epidermal growth factor receptor	Homo sapiens (human)
integrin binding	Epidermal growth factor receptor	Homo sapiens (human)
protein binding	Epidermal growth factor receptor	Homo sapiens (human)
calmodulin binding	Epidermal growth factor receptor	Homo sapiens (human)
ATP binding	Epidermal growth factor receptor	Homo sapiens (human)
enzyme binding	Epidermal growth factor receptor	Homo sapiens (human)
kinase binding	Epidermal growth factor receptor	Homo sapiens (human)
protein kinase binding	Epidermal growth factor receptor	Homo sapiens (human)
protein phosphatase binding	Epidermal growth factor receptor	Homo sapiens (human)
protein tyrosine kinase activator activity	Epidermal growth factor receptor	Homo sapiens (human)
transmembrane receptor protein tyrosine kinase activator activity	Epidermal growth factor receptor	Homo sapiens (human)
ubiquitin protein ligase binding	Epidermal growth factor receptor	Homo sapiens (human)
identical protein binding	Epidermal growth factor receptor	Homo sapiens (human)
cadherin binding	Epidermal growth factor receptor	Homo sapiens (human)
actin filament binding	Epidermal growth factor receptor	Homo sapiens (human)
ATPase binding	Epidermal growth factor receptor	Homo sapiens (human)
epidermal growth factor binding	Epidermal growth factor receptor	Homo sapiens (human)
protease binding	Macrophage migration inhibitory factor	Homo sapiens (human)
dopachrome isomerase activity	Macrophage migration inhibitory factor	Homo sapiens (human)
cytokine activity	Macrophage migration inhibitory factor	Homo sapiens (human)
cytokine receptor binding	Macrophage migration inhibitory factor	Homo sapiens (human)
protein binding	Macrophage migration inhibitory factor	Homo sapiens (human)
chemoattractant activity	Macrophage migration inhibitory factor	Homo sapiens (human)
identical protein binding	Macrophage migration inhibitory factor	Homo sapiens (human)
phenylpyruvate tautomerase activity	Macrophage migration inhibitory factor	Homo sapiens (human)
RNA binding	NAD	Homo sapiens (human)
cytochrome-b5 reductase activity, acting on NAD(P)H	NAD	Homo sapiens (human)
superoxide dismutase activity	NAD	Homo sapiens (human)
protein binding	NAD	Homo sapiens (human)
NADPH dehydrogenase (quinone) activity	NAD	Homo sapiens (human)
identical protein binding	NAD	Homo sapiens (human)
NADH:ubiquinone reductase (non-electrogenic) activity	NAD	Homo sapiens (human)
NAD(P)H dehydrogenase (quinone) activity	NAD	Homo sapiens (human)
protein binding	Kelch-like ECH-associated protein 1	Homo sapiens (human)
identical protein binding	Kelch-like ECH-associated protein 1	Homo sapiens (human)
RNA polymerase II-specific DNA-binding transcription factor binding	Kelch-like ECH-associated protein 1	Homo sapiens (human)
disordered domain specific binding	Kelch-like ECH-associated protein 1	Homo sapiens (human)
ubiquitin-like ligase-substrate adaptor activity	Kelch-like ECH-associated protein 1	Homo sapiens (human)
transcription factor binding	Kelch-like ECH-associated protein 1	Homo sapiens (human)
transcription cis-regulatory region binding	Nuclear factor erythroid 2-related factor 2	Homo sapiens (human)
DNA-binding transcription factor activity, RNA polymerase II-specific	Nuclear factor erythroid 2-related factor 2	Homo sapiens (human)
transcription coregulator binding	Nuclear factor erythroid 2-related factor 2	Homo sapiens (human)
DNA-binding transcription activator activity, RNA polymerase II-specific	Nuclear factor erythroid 2-related factor 2	Homo sapiens (human)
DNA binding	Nuclear factor erythroid 2-related factor 2	Homo sapiens (human)
DNA-binding transcription factor activity	Nuclear factor erythroid 2-related factor 2	Homo sapiens (human)
protein binding	Nuclear factor erythroid 2-related factor 2	Homo sapiens (human)
protein domain specific binding	Nuclear factor erythroid 2-related factor 2	Homo sapiens (human)
ubiquitin protein ligase binding	Nuclear factor erythroid 2-related factor 2	Homo sapiens (human)
sequence-specific DNA binding	Nuclear factor erythroid 2-related factor 2	Homo sapiens (human)
RNA polymerase II-specific DNA-binding transcription factor binding	Nuclear factor erythroid 2-related factor 2	Homo sapiens (human)
molecular condensate scaffold activity	Nuclear factor erythroid 2-related factor 2	Homo sapiens (human)
RNA polymerase II cis-regulatory region sequence-specific DNA binding	Nuclear factor erythroid 2-related factor 2	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Process	via Protein(s)	Taxonomy
nucleus	Transcription regulator protein BACH1	Homo sapiens (human)
cytosol	Transcription regulator protein BACH1	Homo sapiens (human)
nucleus	Transcription regulator protein BACH1	Homo sapiens (human)
nucleoplasm	Transcription regulator protein BACH1	Homo sapiens (human)
cytoplasm	Transcription regulator protein BACH1	Homo sapiens (human)
cytosol	Transcription regulator protein BACH1	Homo sapiens (human)
RNA polymerase II transcription regulator complex	Transcription regulator protein BACH1	Homo sapiens (human)
chromatin	Transcription regulator protein BACH1	Homo sapiens (human)
nucleus	Transcription factor MafK	Homo sapiens (human)
nucleoplasm	Transcription factor MafK	Homo sapiens (human)
RNA polymerase II transcription regulator complex	Transcription factor MafK	Homo sapiens (human)
chromatin	Transcription factor MafK	Homo sapiens (human)
nucleus	Transcription factor MafK	Homo sapiens (human)
endosome	Epidermal growth factor receptor	Homo sapiens (human)
plasma membrane	Epidermal growth factor receptor	Homo sapiens (human)
ruffle membrane	Epidermal growth factor receptor	Homo sapiens (human)
Golgi membrane	Epidermal growth factor receptor	Homo sapiens (human)
extracellular space	Epidermal growth factor receptor	Homo sapiens (human)
nucleus	Epidermal growth factor receptor	Homo sapiens (human)
cytoplasm	Epidermal growth factor receptor	Homo sapiens (human)
endosome	Epidermal growth factor receptor	Homo sapiens (human)
endoplasmic reticulum membrane	Epidermal growth factor receptor	Homo sapiens (human)
plasma membrane	Epidermal growth factor receptor	Homo sapiens (human)
focal adhesion	Epidermal growth factor receptor	Homo sapiens (human)
cell surface	Epidermal growth factor receptor	Homo sapiens (human)
endosome membrane	Epidermal growth factor receptor	Homo sapiens (human)
membrane	Epidermal growth factor receptor	Homo sapiens (human)
basolateral plasma membrane	Epidermal growth factor receptor	Homo sapiens (human)
apical plasma membrane	Epidermal growth factor receptor	Homo sapiens (human)
cell junction	Epidermal growth factor receptor	Homo sapiens (human)
clathrin-coated endocytic vesicle membrane	Epidermal growth factor receptor	Homo sapiens (human)
early endosome membrane	Epidermal growth factor receptor	Homo sapiens (human)
nuclear membrane	Epidermal growth factor receptor	Homo sapiens (human)
membrane raft	Epidermal growth factor receptor	Homo sapiens (human)
perinuclear region of cytoplasm	Epidermal growth factor receptor	Homo sapiens (human)
multivesicular body, internal vesicle lumen	Epidermal growth factor receptor	Homo sapiens (human)
intracellular vesicle	Epidermal growth factor receptor	Homo sapiens (human)
protein-containing complex	Epidermal growth factor receptor	Homo sapiens (human)
receptor complex	Epidermal growth factor receptor	Homo sapiens (human)
Shc-EGFR complex	Epidermal growth factor receptor	Homo sapiens (human)
basal plasma membrane	Epidermal growth factor receptor	Homo sapiens (human)
extracellular region	Macrophage migration inhibitory factor	Homo sapiens (human)
extracellular space	Macrophage migration inhibitory factor	Homo sapiens (human)
nucleoplasm	Macrophage migration inhibitory factor	Homo sapiens (human)
cytoplasm	Macrophage migration inhibitory factor	Homo sapiens (human)
cytosol	Macrophage migration inhibitory factor	Homo sapiens (human)
plasma membrane	Macrophage migration inhibitory factor	Homo sapiens (human)
cell surface	Macrophage migration inhibitory factor	Homo sapiens (human)
vesicle	Macrophage migration inhibitory factor	Homo sapiens (human)
secretory granule lumen	Macrophage migration inhibitory factor	Homo sapiens (human)
extracellular exosome	Macrophage migration inhibitory factor	Homo sapiens (human)
ficolin-1-rich granule lumen	Macrophage migration inhibitory factor	Homo sapiens (human)
extracellular space	Macrophage migration inhibitory factor	Homo sapiens (human)
nucleus	NAD	Homo sapiens (human)
cytoplasm	NAD	Homo sapiens (human)
cytosol	NAD	Homo sapiens (human)
dendrite	NAD	Homo sapiens (human)
neuronal cell body	NAD	Homo sapiens (human)
synapse	NAD	Homo sapiens (human)
cytosol	NAD	Homo sapiens (human)
nucleoplasm	Kelch-like ECH-associated protein 1	Homo sapiens (human)
cytoplasm	Kelch-like ECH-associated protein 1	Homo sapiens (human)
endoplasmic reticulum	Kelch-like ECH-associated protein 1	Homo sapiens (human)
cytosol	Kelch-like ECH-associated protein 1	Homo sapiens (human)
actin filament	Kelch-like ECH-associated protein 1	Homo sapiens (human)
inclusion body	Kelch-like ECH-associated protein 1	Homo sapiens (human)
midbody	Kelch-like ECH-associated protein 1	Homo sapiens (human)
centriolar satellite	Kelch-like ECH-associated protein 1	Homo sapiens (human)
Cul3-RING ubiquitin ligase complex	Kelch-like ECH-associated protein 1	Homo sapiens (human)
mediator complex	Nuclear factor erythroid 2-related factor 2	Homo sapiens (human)
non-membrane-bounded organelle	Nuclear factor erythroid 2-related factor 2	Homo sapiens (human)
nucleus	Nuclear factor erythroid 2-related factor 2	Homo sapiens (human)
nucleoplasm	Nuclear factor erythroid 2-related factor 2	Homo sapiens (human)
cytoplasm	Nuclear factor erythroid 2-related factor 2	Homo sapiens (human)
Golgi apparatus	Nuclear factor erythroid 2-related factor 2	Homo sapiens (human)
centrosome	Nuclear factor erythroid 2-related factor 2	Homo sapiens (human)
cytosol	Nuclear factor erythroid 2-related factor 2	Homo sapiens (human)
plasma membrane	Nuclear factor erythroid 2-related factor 2	Homo sapiens (human)
RNA polymerase II transcription regulator complex	Nuclear factor erythroid 2-related factor 2	Homo sapiens (human)
chromatin	Nuclear factor erythroid 2-related factor 2	Homo sapiens (human)
protein-DNA complex	Nuclear factor erythroid 2-related factor 2	Homo sapiens (human)
nucleus	Nuclear factor erythroid 2-related factor 2	Homo sapiens (human)
nucleoplasm	Nuclear factor erythroid 2-related factor 2	Mus musculus (house mouse)
cytoplasm	Nuclear factor erythroid 2-related factor 2	Mus musculus (house mouse)
cytosol	Nuclear factor erythroid 2-related factor 2	Mus musculus (house mouse)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (367)

Assay ID	Title	Year	Journal	Article
AID361394	Induction of NADPH:quinone reductase activity in mouse Hepa-1c1c7 cells assessed as drug level required to double specific enzyme activity after 48 hrs by MTT assay	2002	Journal of natural products, Nov, Volume: 65, Issue:11	Activity-guided isolation of constituents of Renealmia nicolaioides with the potential to induce the phase II enzyme quinone reductase.
AID436140	Antiproliferative activity against human LTEP-A2 cells by trypan blue exclusion assay	2008	Journal of natural products, Nov, Volume: 71, Issue:11	Sulforaphane induces cell-cycle arrest and apoptosis in cultured human lung adenocarcinoma LTEP-A2 cells and retards growth of LTEP-A2 xenografts in vivo.
AID754019	Cell cycle arrest in human HepG2 cells assessed as accumulation at S phase at 20 uM after 48 hrs by DAPI staining-based flow cytometric analysis relative to control	2013	European journal of medicinal chemistry, Jun, Volume: 64	Synthesis and biological evaluation of sulforaphane derivatives as potential antitumor agents.
AID1252704	Chemical stability of the compound in 3,3-dimethylglutarate buffer containing DTPA, sodium acetate, Tween 80 at pH 7.0 at 30 degC incubated for 2.5 hrs prior to addition of PTP1B	2015	Bioorganic & medicinal chemistry letters, Oct-15, Volume: 25, Issue:20	Inactivation of protein tyrosine phosphatases by dietary isothiocyanates.
AID1339466	Activation of Nrf2 (unknown origin) expressed in human HepG2 cells after 5 hrs by ARE-driven luciferase reporter gene assay relative to control	2017	Bioorganic & medicinal chemistry, 02-15, Volume: 25, Issue:4	Activation of anti-oxidant Nrf2 signaling by substituted trans stilbenes.
AID754016	Induction of apoptosis in human HepG2 cells assessed as early apoptotic cells at 20 uM after 48 hrs by Annexin-V-FITC/propidium iodide staining-based flow cytometric analysis (Rvb = 0.14%)	2013	European journal of medicinal chemistry, Jun, Volume: 64	Synthesis and biological evaluation of sulforaphane derivatives as potential antitumor agents.
AID754024	Cytotoxicity against human SH-SY5Y cells after 72 hrs by MTT assay	2013	European journal of medicinal chemistry, Jun, Volume: 64	Synthesis and biological evaluation of sulforaphane derivatives as potential antitumor agents.
AID1400546	Activation of Nrf2 in human MDA-MB-231 cells assessed as upregulation of gamma-GCS protein expression at 2 uM after 16 hrs by immunoblot analysis	2018	Bioorganic & medicinal chemistry, 10-01, Volume: 26, Issue:18	Discovery of natural flavonoids as activators of Nrf2-mediated defense system: Structure-activity relationship and inhibition of intracellular oxidative insults.
AID707936	Increase in MAPK signaling pathway related gene expression in human PNT1A cells at 10 uM incubated for 8 hrs by Affymetrix human exon array relative to untreated control	2012	Journal of medicinal chemistry, Nov-26, Volume: 55, Issue:22	Enhanced in vitro biological activity of synthetic 2-(2-pyridyl) ethyl isothiocyanate compared to natural 4-(methylsulfinyl) butyl isothiocyanate.
AID1713571	Chemopreventive index, ratio of IC50 for mouse Hepa-1c1c7 cells to drug level required to double NADPH:quinone reductase activity in mouse Hepa-1c1c7 cells	2016	Bioorganic & medicinal chemistry letters, 10-15, Volume: 26, Issue:20	Systemic structure-activity relationship study of phenyl polyyne diols as potential chemopreventive agents.
AID1418246	Antiproliferative activity against human SMMC7721 cells assessed as inhibition of cell proliferation at 16 uM after 72 hrs by CCK8 assay	2018	European journal of medicinal chemistry, Sep-05, Volume: 157	Design, synthesis and biological evaluation of novel carbamodithioates as anti-proliferative agents against human cancer cells.
AID1676346	Inhibition of Keap1-Nrf2 protein-protein interaction in human HepG2-ARE-C8 cells assessed as Nrf2 activation mediated ARE-driven luciferase activity by measuring fold change at 0.01 uM measured after 12 hrs by luciferase reporter gene assay	2020	Journal of medicinal chemistry, 10-08, Volume: 63, Issue:19	Design, Synthesis, and Structure-Activity Relationships of Indoline-Based Kelch-like ECH-Associated Protein 1-Nuclear Factor (Erythroid-Derived 2)-Like 2 (Keap1-Nrf2) Protein-Protein Interaction Inhibitors.
AID1418264	Induction of apoptosis in human SMMC7721 cells assessed as viable cells at 8 uM after 72 hrs by Alexa Fluor 488 Annexin/propidium iodide staining-based flow cytometric analysis (Rvb = 91.92%)	2018	European journal of medicinal chemistry, Sep-05, Volume: 157	Design, synthesis and biological evaluation of novel carbamodithioates as anti-proliferative agents against human cancer cells.
AID1418259	Induction of apoptosis in human SMMC7721 cells assessed as early apoptotic cells at 4 uM after 72 hrs by Alexa Fluor 488 Annexin/propidium iodide staining-based flow cytometric analysis (Rvb = 0.70%)	2018	European journal of medicinal chemistry, Sep-05, Volume: 157	Design, synthesis and biological evaluation of novel carbamodithioates as anti-proliferative agents against human cancer cells.
AID436127	Cell cycle arrest in human LTEP-A2 cells assessed as accumulation at G2/M phase at 50 uM after 72 hrs by flow cytometry	2008	Journal of natural products, Nov, Volume: 71, Issue:11	Sulforaphane induces cell-cycle arrest and apoptosis in cultured human lung adenocarcinoma LTEP-A2 cells and retards growth of LTEP-A2 xenografts in vivo.
AID1713569	Induction of quinone reductase activity in mouse Hepa1c1c7 cells	2016	Bioorganic & medicinal chemistry letters, 10-15, Volume: 26, Issue:20	Systemic structure-activity relationship study of phenyl polyyne diols as potential chemopreventive agents.
AID480522	Induction of NQO1 activity in human B1647 cells at 5 uM after 24 to 48 hrs by fluorescence plate reader	2010	Bioorganic & medicinal chemistry, May-01, Volume: 18, Issue:9	Antitumor activity and COMPARE analysis of bis-indole derivatives.
AID476683	Induction of NrF2-mediated glutathione production in wild type MEF at 10 uM after 24 hrs using Elmans reagent relative to control	2010	Bioorganic & medicinal chemistry letters, Apr-15, Volume: 20, Issue:8	Enhanced Nrf2-dependent induction of glutathione in mouse embryonic fibroblasts by isoselenocyanate analog of sulforaphane.
AID754027	Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay	2013	European journal of medicinal chemistry, Jun, Volume: 64	Synthesis and biological evaluation of sulforaphane derivatives as potential antitumor agents.
AID1128080	Inhibition of Keap1-Nrf2 interaction in human HepG2-ARE-C8 cells assessed as activation of Nrf2-ARE luciferase activity at 10 uM after 12 hrs relative to control	2014	Journal of medicinal chemistry, Mar-27, Volume: 57, Issue:6	Discovery of potent Keap1-Nrf2 protein-protein interaction inhibitor based on molecular binding determinants analysis.
AID1400565	Activation of Nrf2 in human BEAS2B cells assessed as upregulation of Nrf2 protein expression at 2 uM after 12 hrs by immunoblot analysis	2018	Bioorganic & medicinal chemistry, 10-01, Volume: 26, Issue:18	Discovery of natural flavonoids as activators of Nrf2-mediated defense system: Structure-activity relationship and inhibition of intracellular oxidative insults.
AID436137	Induction of apoptosis in human LTEP-A2 cells assessed as sub-G0/G1 DNA content by propidium iodide based flow cytometry	2008	Journal of natural products, Nov, Volume: 71, Issue:11	Sulforaphane induces cell-cycle arrest and apoptosis in cultured human lung adenocarcinoma LTEP-A2 cells and retards growth of LTEP-A2 xenografts in vivo.
AID436105	Cell cycle arrest in human LTEP-A2 cells assessed as accumulation at G0/G1 phase at 6.25 uM after 24 hrs by flow cytometry	2008	Journal of natural products, Nov, Volume: 71, Issue:11	Sulforaphane induces cell-cycle arrest and apoptosis in cultured human lung adenocarcinoma LTEP-A2 cells and retards growth of LTEP-A2 xenografts in vivo.
AID1579160	Antiproliferative activity against human HeLa cells assessed as inhibition of cell viability after 72 hrs by CCK-8 assay	2019	European journal of medicinal chemistry, Nov-01, Volume: 181	Novel cyclin-dependent kinase 9 (CDK9) inhibitor with suppression of cancer stemness activity against non-small-cell lung cancer.
AID707931	Cytotoxicity against human HepG2 cells incubated for 24 hrs by WST1 dye reduction assay	2012	Journal of medicinal chemistry, Nov-26, Volume: 55, Issue:22	Enhanced in vitro biological activity of synthetic 2-(2-pyridyl) ethyl isothiocyanate compared to natural 4-(methylsulfinyl) butyl isothiocyanate.
AID1418268	Cell cycle arrest in human SMMC7721 cells assessed as accumulation at G0/G1 phase at 8 uM after 72 hrs by RNase/propidium iodide staining-based flow cytometric analysis (Rvb = 67.26%)	2018	European journal of medicinal chemistry, Sep-05, Volume: 157	Design, synthesis and biological evaluation of novel carbamodithioates as anti-proliferative agents against human cancer cells.
AID1700337	Activation of Nrf2 in human glomerular mesangial cells assessed as translocation of Nrf2 from cytoplasm to nucleus at 10 uM under high glucose condition by DAPI staining based fluorescence microscopy analysis	2020	Bioorganic & medicinal chemistry, 12-15, Volume: 28, Issue:24	Discovery of polypodiside as a Keap1-dependent Nrf2 activator attenuating oxidative stress and accumulation of extracellular matrix in glomerular mesangial cells under high glucose.
AID1248057	Increase of Nrf2 protein level in mouse Hepa1c1c7 cells at 10 uM by Western blot analysis	2015	Journal of medicinal chemistry, Sep-24, Volume: 58, Issue:18	Design, Synthesis, and Evaluation of Triazole Derivatives That Induce Nrf2 Dependent Gene Products and Inhibit the Keap1-Nrf2 Protein-Protein Interaction.
AID1579151	Antiproliferative activity against human A549 cells assessed as inhibition of cell viability after 72 hrs by CCK-8 assay	2019	European journal of medicinal chemistry, Nov-01, Volume: 181	Novel cyclin-dependent kinase 9 (CDK9) inhibitor with suppression of cancer stemness activity against non-small-cell lung cancer.
AID1536349	Binding affinity to human N-terminal His6-tagged Keap1 C151S mutant (35 to 182 residues) expressed in baculovirus infected Sf9 insect cells assessed as cysteine-compound adduct formation at 15-fold molar excess measured after 1 hr by RP-LC/MS/MS analysis	2019	Bioorganic & medicinal chemistry, 02-15, Volume: 27, Issue:4	Discovery of a crystalline sulforaphane analog with good solid-state stability and engagement of the Nrf2 pathway in vitro and in vivo.
AID1377163	Cytotoxicity against mouse Hepa1c1c7 cells assessed as reduction in cell viability by MTT assay	2017	Journal of natural products, 06-23, Volume: 80, Issue:6	Botrysphones A-C and Botrysphins A-F, Triketides and Diterpenoids from the Fungus Botrysphaeria laricina.
AID773885	Induction of Nrf2-mediated ARE activity in human HepG2-ARE-C8 cells after 12 hrs by luciferase reporter gene assay	2013	Journal of medicinal chemistry, Oct-24, Volume: 56, Issue:20	3-aroylmethylene-2,3,6,7-tetrahydro-1H-pyrazino[2,1-a]isoquinolin-4(11bH)-ones as potent Nrf2/ARE inducers in human cancer cells and AOM-DSS treated mice.
AID1826671	Antioxidant activity assessed as trolox equivalent of ORAC radical scavenging activity preincubated for 15 mins followed by AAPH addition by ORAC-FL assay	2022	Journal of medicinal chemistry, 03-24, Volume: 65, Issue:6	Resveratrol-Based MTDLs to Stimulate Defensive and Regenerative Pathways and Block Early Events in Neurodegenerative Cascades.
AID476685	Induction of NrF2 in human HepG2 cells at 20 uM after 6 hrs by ARE-luciferase reporter gene assay relative to control	2010	Bioorganic & medicinal chemistry letters, Apr-15, Volume: 20, Issue:8	Enhanced Nrf2-dependent induction of glutathione in mouse embryonic fibroblasts by isoselenocyanate analog of sulforaphane.
AID707916	Increase in hematopoietic cell lineage related gene expression in human PNT1A cells at 10 uM incubated for 8 hrs by Affymetrix human exon array relative to untreated control	2012	Journal of medicinal chemistry, Nov-26, Volume: 55, Issue:22	Enhanced in vitro biological activity of synthetic 2-(2-pyridyl) ethyl isothiocyanate compared to natural 4-(methylsulfinyl) butyl isothiocyanate.
AID436108	Cell cycle arrest in human LTEP-A2 cells assessed as accumulation at S phase at 6.25 uM after 3 hrs by flow cytometry	2008	Journal of natural products, Nov, Volume: 71, Issue:11	Sulforaphane induces cell-cycle arrest and apoptosis in cultured human lung adenocarcinoma LTEP-A2 cells and retards growth of LTEP-A2 xenografts in vivo.
AID605649	Induction of quinone reductase-1 activity in mouse Hepa-1c1c7 cells assessed as concentration required to double induction activity after 48 hrs by MTT assay	2010	Journal of medicinal chemistry, Dec-23, Volume: 53, Issue:24	Potential chemopreventive agents based on the structure of the lead compound 2-bromo-1-hydroxyphenazine, isolated from Streptomyces species, strain CNS284.
AID380749	Chemoprevention index, ratio of IC50 for mouse Hepa-1c1c7 cells to drug level required to double specific NADPH:quinone reductase activity in mouse Hepa-1c1c7 cells	2006	Journal of natural products, Mar, Volume: 69, Issue:3	Quinone reductase induction as a biomarker for cancer chemoprevention.
AID1418260	Induction of apoptosis in human SMMC7721 cells assessed as viable cells at 4 uM after 72 hrs by Alexa Fluor 488 Annexin/propidium iodide staining-based flow cytometric analysis (Rvb = 91.92%)	2018	European journal of medicinal chemistry, Sep-05, Volume: 157	Design, synthesis and biological evaluation of novel carbamodithioates as anti-proliferative agents against human cancer cells.
AID1536357	Activation of Keap1/Cul3/Nrf2 in human BEAS2B cells assessed as increase in NQO1 levels measured after 48 hrs	2019	Bioorganic & medicinal chemistry, 02-15, Volume: 27, Issue:4	Discovery of a crystalline sulforaphane analog with good solid-state stability and engagement of the Nrf2 pathway in vitro and in vivo.
AID1577827	Binding affinity to Keap1 in mouse Hepa1c1c7 cells assessed as reduction in Keap1 interaction by measuring induction of NQO1 activity at 10 uM measured after 24 hrs	2019	Journal of medicinal chemistry, 09-12, Volume: 62, Issue:17	A Comparative Assessment Study of Known Small-Molecule Keap1-Nrf2 Protein-Protein Interaction Inhibitors: Chemical Synthesis, Binding Properties, and Cellular Activity.
AID1248056	Increase of Nrf2 protein level in mouse Hepa1c1c7 cells at 10 uM after 6 hrs by Western blot analysis	2015	Journal of medicinal chemistry, Sep-24, Volume: 58, Issue:18	Design, Synthesis, and Evaluation of Triazole Derivatives That Induce Nrf2 Dependent Gene Products and Inhibit the Keap1-Nrf2 Protein-Protein Interaction.
AID334284	Chemoprevention index, ratio of IC50 for mouse Hepa-1c1c7 cells to drug level required to double specific quinone reductase activity in mouse Hepa-1c1c7 cells	2002	Journal of natural products, May, Volume: 65, Issue:5	Induction of quinone reductase by withanolides.
AID1418253	Drug degradation in methanol after 10 hrs at 50 degC by HPLC analysis	2018	European journal of medicinal chemistry, Sep-05, Volume: 157	Design, synthesis and biological evaluation of novel carbamodithioates as anti-proliferative agents against human cancer cells.
AID1579189	Induction of apoptosis in human H1299 cells assessed as late apoptotic cells at 1 uM after 48 hrs by AnnexinV-FITC/PI staining-based flow cytometric analysis (Rvb = 1.77%)	2019	European journal of medicinal chemistry, Nov-01, Volume: 181	Novel cyclin-dependent kinase 9 (CDK9) inhibitor with suppression of cancer stemness activity against non-small-cell lung cancer.
AID1474562	Induction of apoptosis in human LoVo/DX cells assessed as loss of mitochondrial membrane potential at 15 uM after 24 hrs by JC-1 staining based flow cytometric method relative to control	2017	European journal of medicinal chemistry, May-26, Volume: 132	Novel phosphonate analogs of sulforaphane: Synthesis, in vitro and in vivo anticancer activity.
AID1765444	Inhibition of Keap1-Nrf2 interaction in mouse peritoneal macrophages assessed as increase in nuclear translocation of Nrf2 by measuring decrease in cytosolic Nrf2 level at 10 uM measured after 3 to 6 hrs by Western blot analysis	2021	European journal of medicinal chemistry, Oct-15, Volume: 222	Structure-based molecular hybridization design of Keap1-Nrf2 inhibitors as novel protective agents of acute lung injury.
AID490165	Increase of Nrf2 protein level in mouse Hepa-1c1c7 cells at 10 uM for 6 hrs Western blotting relative to control	2010	European journal of medicinal chemistry, Jul, Volume: 45, Issue:7	Functionalized aurones as inducers of NAD(P)H:quinone oxidoreductase 1 that activate AhR/XRE and Nrf2/ARE signaling pathways: synthesis, evaluation and SAR.
AID380757	Induction of NADPH:quinone reductase activity in mouse Hepa-1c1c7 Bprc1 mutant cells assessed as drug level required to double specific enzyme activity	2006	Journal of natural products, Mar, Volume: 69, Issue:3	Quinone reductase induction as a biomarker for cancer chemoprevention.
AID436150	Antiproliferative activity against human LTEP-A2 cells after 24 hrs by trypan blue exclusion assay	2008	Journal of natural products, Nov, Volume: 71, Issue:11	Sulforaphane induces cell-cycle arrest and apoptosis in cultured human lung adenocarcinoma LTEP-A2 cells and retards growth of LTEP-A2 xenografts in vivo.
AID356304	Growth inhibition of mouse Hepa-1c1c7 cells	2003	Journal of natural products, Aug, Volume: 66, Issue:8	Isolation and characterization of miscellaneous secondary metabolites of Deprea subtriflora.
AID707929	Cytotoxicity against human PC3 cells incubated for 24 hrs by WST1 dye reduction assay	2012	Journal of medicinal chemistry, Nov-26, Volume: 55, Issue:22	Enhanced in vitro biological activity of synthetic 2-(2-pyridyl) ethyl isothiocyanate compared to natural 4-(methylsulfinyl) butyl isothiocyanate.
AID1243387	Chemopreventive index, ratio of IC50 for mouse Hepa-1c1c7 cells to drug concentration required to double induction of NQO1 in mouse Hepa-1c1c7 cells	2015	Bioorganic & medicinal chemistry letters, Sep-15, Volume: 25, Issue:18	Identification of dialkyl diacetylene diols with potent cancer chemopreventive activity.
AID606521	Induction of Nrf2-mediated GCLM gene expression in human BEAS2B cells at 10 uM after 16 hrs by RT-PCR analysis relative to untreated control	2011	Journal of medicinal chemistry, Jun-23, Volume: 54, Issue:12	Novel chalcone derivatives as potent Nrf2 activators in mice and human lung epithelial cells.
AID380495	Induction of ARE in human HepG2 cells by luciferase assay	2006	Journal of natural products, Mar, Volume: 69, Issue:3	Bioactive dammarane triterpenes from the mangrove plant Bruguiera gymnorrhiza.
AID436131	Induction of apoptosis in human LTEP-A2 cells assessed as sub-G0/G1 DNA content at 6.25 uM after 72 hrs by propidium iodide based flow cytometry	2008	Journal of natural products, Nov, Volume: 71, Issue:11	Sulforaphane induces cell-cycle arrest and apoptosis in cultured human lung adenocarcinoma LTEP-A2 cells and retards growth of LTEP-A2 xenografts in vivo.
AID436295	Induction of NADPH-quinone reductase activity in mouse Hepa-1c1c7 cells assessed as drug level required to double specific enzyme activity by MTT assay	2008	Journal of natural products, Nov, Volume: 71, Issue:11	Monodictyochromes A and B, dimeric xanthone derivatives from the marine algicolous fungus Monodictys putredinis.
AID490164	Induction of human NQO1 gene expression in mouse Hepa-1c1c7 cells co-transfected with pGL3-ARE at 10 to 25 uM after 24 hrs by luciferase reporter gene assay	2010	European journal of medicinal chemistry, Jul, Volume: 45, Issue:7	Functionalized aurones as inducers of NAD(P)H:quinone oxidoreductase 1 that activate AhR/XRE and Nrf2/ARE signaling pathways: synthesis, evaluation and SAR.
AID1054579	Ratio of residual Vmax to Km for recombinant human MAO-A expressed in baculovirus infected BT1 cells assessed as residual activity using benzylamine as substrate at 20 uM preincubated for 30 mins by Amplex Red assay	2013	European journal of medicinal chemistry, , Volume: 70	Novel polyamine analogues: from substrates towards potential inhibitors of monoamine oxidases.
AID1248062	Inhibition of mCherry labeled Keap1 interaction to DLG motif from Nrf2 in human HEK293 cells at 10 uM by FRET based assay	2015	Journal of medicinal chemistry, Sep-24, Volume: 58, Issue:18	Design, Synthesis, and Evaluation of Triazole Derivatives That Induce Nrf2 Dependent Gene Products and Inhibit the Keap1-Nrf2 Protein-Protein Interaction.
AID380760	Induction of NADPH:quinone reductase activity in mouse Hepa-1c1c7 TAOc1Bprc1 mutant cells assessed as drug level required to double specific enzyme activity	2006	Journal of natural products, Mar, Volume: 69, Issue:3	Quinone reductase induction as a biomarker for cancer chemoprevention.
AID754015	Induction of apoptosis in human HepG2 cells assessed as late apoptotic cells at 5 uM after 48 hrs by Annexin-V-FITC/propidium iodide staining-based flow cytometric analysis (Rvb = 0.29%)	2013	European journal of medicinal chemistry, Jun, Volume: 64	Synthesis and biological evaluation of sulforaphane derivatives as potential antitumor agents.
AID1910666	Cytotoxicity against human ARPE-19 cells assessed as reduction in cell viability incubated for 96 hrs by MTT assay	2022	Journal of medicinal chemistry, 05-26, Volume: 65, Issue:10	Phenyl Bis-Sulfonamide Keap1-Nrf2 Protein-Protein Interaction Inhibitors with an Alternative Binding Mode.
AID754011	Activation of NRF2 in human HepG2 cells after 6 hrs by spectrophotometric analysis	2013	European journal of medicinal chemistry, Jun, Volume: 64	Synthesis and biological evaluation of sulforaphane derivatives as potential antitumor agents.
AID417752	Induction of CYP1A1 activity in mouse Hepa-1c1c7 cells assessed as induction ratio at 1 uM after 48 hrs by EROD assay relative to control	2009	Bioorganic & medicinal chemistry, Mar-01, Volume: 17, Issue:5	Functionalized 3-benzylidene-indolin-2-ones: inducers of NAD(P)H-quinone oxidoreductase 1 (NQO1) with antiproliferative activity.
AID692258	Induction of conformational changes in p53 G245C mutant in human NCI-H596 cells at 60 uM incubated for 1 hr at 32 degC by tryptophan fluorescence emission spectroscopy	2011	Journal of medicinal chemistry, Feb-10, Volume: 54, Issue:3	Selective depletion of mutant p53 by cancer chemopreventive isothiocyanates and their structure-activity relationships.
AID334281	Induction of quinone reductase activity in mouse Hepa-1c1c7 cells assessed as drug level required to double enzyme activity after 48 hrs by NADPH-dependent MTT reduction assay	2002	Journal of natural products, May, Volume: 65, Issue:5	Induction of quinone reductase by withanolides.
AID1075382	Induction of Nrf2-dependent HO1 protein level in mouse BV-2 cells at 5 uM after 24 hrs by sandwich ELISA	2014	Journal of medicinal chemistry, Feb-27, Volume: 57, Issue:4	Discovery of vinyl sulfones as a novel class of neuroprotective agents toward Parkinson's disease therapy.
AID1577832	Binding affinity to Keap1 in mouse Hepa1c1c7 cells assessed as reduction in Keap1 interaction by measuring induction of NQO1 activity at 10 uM in 0.13% DMSO measured after 24 hrs	2019	Journal of medicinal chemistry, 09-12, Volume: 62, Issue:17	A Comparative Assessment Study of Known Small-Molecule Keap1-Nrf2 Protein-Protein Interaction Inhibitors: Chemical Synthesis, Binding Properties, and Cellular Activity.
AID1676349	Inhibition of Keap1-Nrf2 protein-protein interaction in human HepG2-ARE-C8 cells assessed as Nrf2 activation mediated ARE-driven luciferase activity by measuring fold change at 5 uM measured after 12 hrs by luciferase reporter gene assay	2020	Journal of medicinal chemistry, 10-08, Volume: 63, Issue:19	Design, Synthesis, and Structure-Activity Relationships of Indoline-Based Kelch-like ECH-Associated Protein 1-Nuclear Factor (Erythroid-Derived 2)-Like 2 (Keap1-Nrf2) Protein-Protein Interaction Inhibitors.
AID606615	Induction of Nrf2-mediated GCLM gene expression in small intestine of C57BL/6 mouse at 50 mg/kg, po administered as single dose measured after 24 hrs by RT-PCR analysis related to control	2011	Journal of medicinal chemistry, Jun-23, Volume: 54, Issue:12	Novel chalcone derivatives as potent Nrf2 activators in mice and human lung epithelial cells.
AID436125	Cell cycle arrest in human LTEP-A2 cells assessed as accumulation at G2/M phase at 50 uM after 24 hrs by flow cytometry	2008	Journal of natural products, Nov, Volume: 71, Issue:11	Sulforaphane induces cell-cycle arrest and apoptosis in cultured human lung adenocarcinoma LTEP-A2 cells and retards growth of LTEP-A2 xenografts in vivo.
AID754018	Induction of apoptosis in human HepG2 cells assessed as early apoptotic cells at 5 uM after 48 hrs by Annexin-V-FITC/propidium iodide staining-based flow cytometric analysis (Rvb = 0.14%)	2013	European journal of medicinal chemistry, Jun, Volume: 64	Synthesis and biological evaluation of sulforaphane derivatives as potential antitumor agents.
AID1765446	Inhibition of Keap1-Nrf2 interaction in mouse peritoneal macrophages assessed as upregulation of NQO1 protein expression at 10 uM by Western blot analysis	2021	European journal of medicinal chemistry, Oct-15, Volume: 222	Structure-based molecular hybridization design of Keap1-Nrf2 inhibitors as novel protective agents of acute lung injury.
AID436117	Cell cycle arrest in human LTEP-A2 cells assessed as accumulation at G0/G1 phase at 50 uM after 24 hrs by flow cytometry	2008	Journal of natural products, Nov, Volume: 71, Issue:11	Sulforaphane induces cell-cycle arrest and apoptosis in cultured human lung adenocarcinoma LTEP-A2 cells and retards growth of LTEP-A2 xenografts in vivo.
AID1226966	Inhibition of iNOS in LPS-stimulated mouse RAW264.7 cells assessed as inhibition of nitric oxide production after 48 hrs by Griess assay	2015	Journal of medicinal chemistry, Jun-11, Volume: 58, Issue:11	New Monocyclic, Bicyclic, and Tricyclic Ethynylcyanodienones as Activators of the Keap1/Nrf2/ARE Pathway and Inhibitors of Inducible Nitric Oxide Synthase.
AID380758	Inhibition of mouse Hepa-1c1c7 Bprc1 mutant cells assessed as cell viability	2006	Journal of natural products, Mar, Volume: 69, Issue:3	Quinone reductase induction as a biomarker for cancer chemoprevention.
AID754021	Cell cycle arrest in human HepG2 cells assessed as decrease in accumulation at G0/G1 phase after 48 hrs by DAPI staining-based flow cytometric analysis	2013	European journal of medicinal chemistry, Jun, Volume: 64	Synthesis and biological evaluation of sulforaphane derivatives as potential antitumor agents.
AID1400567	Activation of Nrf2 in human BEAS2B cells assessed as upregulation of gamma-GCS protein expression at 2 uM after 12 hrs by immunoblot analysis	2018	Bioorganic & medicinal chemistry, 10-01, Volume: 26, Issue:18	Discovery of natural flavonoids as activators of Nrf2-mediated defense system: Structure-activity relationship and inhibition of intracellular oxidative insults.
AID1657401	Activation of Nrf2 in human BEAS2B cells harboring Keap1-C273S mutant assessed as increase in Nrf2 protein expression at 5 uM after12 hrs in presence of Keap1-siRNA by immunoblot analysis	2020	Journal of natural products, 04-24, Volume: 83, Issue:4	4β-Hydroxywithanolide E from Goldenberry (Whole Fruits of
AID1252692	Reversible inhibition of recombinant human PTP1B catalytic domain (1 to 322 amino acid residues) in 3,3-dimethylglutarate buffer assessed as inactivation constant kf	2015	Bioorganic & medicinal chemistry letters, Oct-15, Volume: 25, Issue:20	Inactivation of protein tyrosine phosphatases by dietary isothiocyanates.
AID334058	Cytotoxicity against mouse Hepa-1c1c7 cells assessed as cell survival after 2 days by MTT assay	1997	Journal of natural products, Sep, Volume: 60, Issue:9	Activity-guided isolation of constituents of Tephrosia purpurea with the potential to induce the phase II enzyme, quinone reductase.
AID680819	TP_TRANSPORTER: Northern blot in vitro, primary human hepatocyte	2001	Biochemical and biophysical research communications, Mar-23, Volume: 282, Issue:1	Reactive oxygen species-related induction of multidrug resistance-associated protein 2 expression in primary hepatocytes exposed to sulforaphane.
AID334059	Chemoprevention index, ratio of IC50 for mouse Hepa-1c1c7 cells to drug level required to double quinone reductase activity in mouse Hepa-1c1c7 cells	1997	Journal of natural products, Sep, Volume: 60, Issue:9	Activity-guided isolation of constituents of Tephrosia purpurea with the potential to induce the phase II enzyme, quinone reductase.
AID1303328	Antiproliferative activity against human A431 cells assessed as cell growth inhibition after 72 hrs by MTT assay	2016	European journal of medicinal chemistry, Jul-19, Volume: 117	Combined inhibition of the EGFR/AKT pathways by a novel conjugate of quinazoline with isothiocyanate.
AID1736435	Activation of NRF2 in human AREc32 cells incubated for 24 hrs by luciferase reporter gene assay	2020	European journal of medicinal chemistry, Mar-15, Volume: 190	Tuning melatonin receptor subtype selectivity in oxadiazolone-based analogues: Discovery of QR2 ligands and NRF2 activators with neurogenic properties.
AID707924	Induction of p21 protein expression in human PC3 cells at 10 uM incubated for 8 hrs by Western blotting relative to untreated control	2012	Journal of medicinal chemistry, Nov-26, Volume: 55, Issue:22	Enhanced in vitro biological activity of synthetic 2-(2-pyridyl) ethyl isothiocyanate compared to natural 4-(methylsulfinyl) butyl isothiocyanate.
AID481441	Aqueous diffusivity at 37C	2010	Journal of medicinal chemistry, May-13, Volume: 53, Issue:9	How well can the Caco-2/Madin-Darby canine kidney models predict effective human jejunal permeability?
AID707918	Increase in systemic lupus erythematosus related gene expression in human PNT1A cells at 10 uM incubated for 8 hrs by Affymetrix human exon array relative to untreated control	2012	Journal of medicinal chemistry, Nov-26, Volume: 55, Issue:22	Enhanced in vitro biological activity of synthetic 2-(2-pyridyl) ethyl isothiocyanate compared to natural 4-(methylsulfinyl) butyl isothiocyanate.
AID436129	Induction of apoptosis in human LTEP-A2 cells assessed as sub-G0/G1 DNA content at 6.25 uM after 24 hrs by propidium iodide based flow cytometry	2008	Journal of natural products, Nov, Volume: 71, Issue:11	Sulforaphane induces cell-cycle arrest and apoptosis in cultured human lung adenocarcinoma LTEP-A2 cells and retards growth of LTEP-A2 xenografts in vivo.
AID680815	TP_TRANSPORTER: Western in vitro, primary human hepatocyte	2001	Biochemical and biophysical research communications, Mar-23, Volume: 282, Issue:1	Reactive oxygen species-related induction of multidrug resistance-associated protein 2 expression in primary hepatocytes exposed to sulforaphane.
AID1418248	Antiproliferative activity against human SMMC7721 cells after 72 hrs by CCK8 assay	2018	European journal of medicinal chemistry, Sep-05, Volume: 157	Design, synthesis and biological evaluation of novel carbamodithioates as anti-proliferative agents against human cancer cells.
AID1252696	Inhibition of recombinant human SHP2 catalytic domain (246 to 527 amino acid residues) in 3,3-dimethylglutarate buffer using pNPP as substrate assessed as p-nitrophenolate release by spectrophotometric analysis	2015	Bioorganic & medicinal chemistry letters, Oct-15, Volume: 25, Issue:20	Inactivation of protein tyrosine phosphatases by dietary isothiocyanates.
AID707928	Antiproliferative activity against human PNT1A cells at 50 uM incubated for 24 hrs by BrdU incorporation assay	2012	Journal of medicinal chemistry, Nov-26, Volume: 55, Issue:22	Enhanced in vitro biological activity of synthetic 2-(2-pyridyl) ethyl isothiocyanate compared to natural 4-(methylsulfinyl) butyl isothiocyanate.
AID356414	Induction of NADPH:quinone reductase activity in mouse Hepa-1c1c7 cells assessed as drug level required to double specific enzyme activity	2003	Journal of natural products, Sep, Volume: 66, Issue:9	Constituents of the stem bark of Pongamia pinnata with the potential to induce quinone reductase.
AID606617	Induction of Nrf2-mediated NQO1 gene expression in small intestine of C57BL/6 mouse at 50 mg/kg, po administered as single dose measured after 24 hrs by RT-PCR analysis related to control	2011	Journal of medicinal chemistry, Jun-23, Volume: 54, Issue:12	Novel chalcone derivatives as potent Nrf2 activators in mice and human lung epithelial cells.
AID1128077	Inhibition of Keap1-Nrf2 interaction in human HepG2-ARE-C8 cells assessed as activation of Nrf2-ARE luciferase activity at 1 uM after 12 hrs relative to control	2014	Journal of medicinal chemistry, Mar-27, Volume: 57, Issue:6	Discovery of potent Keap1-Nrf2 protein-protein interaction inhibitor based on molecular binding determinants analysis.
AID1474558	Induction of apoptosis in human LoVo cells assessed as increase in caspase3/7 activity at 15 uM using Ac-DEVD-ACC as substrate pretreated for 24 hrs followed by substrate addition measured for 2 hrs by fluorescence assay relative to control	2017	European journal of medicinal chemistry, May-26, Volume: 132	Novel phosphonate analogs of sulforaphane: Synthesis, in vitro and in vivo anticancer activity.
AID773888	Induction of Nrf2-mediated ARE activity in human HepG2-ARE-C8 cells at 1 uM after 12 hrs by luciferase reporter gene assay relative to control	2013	Journal of medicinal chemistry, Oct-24, Volume: 56, Issue:20	3-aroylmethylene-2,3,6,7-tetrahydro-1H-pyrazino[2,1-a]isoquinolin-4(11bH)-ones as potent Nrf2/ARE inducers in human cancer cells and AOM-DSS treated mice.
AID380762	Chemoprevention index, ratio of IC50 for mouse Hepa-1c1c7 TAOc1Bprc1 mutant cells to drug level required to double specific NADPH:quinone reductase activity in mouse Hepa-1c1c7 TAOc1Bprc1 mutant cells	2006	Journal of natural products, Mar, Volume: 69, Issue:3	Quinone reductase induction as a biomarker for cancer chemoprevention.
AID476673	Cytotoxicity against human HepG2 cells assessed as cell viability at 50 uM after 6 hrs by MTS assay	2010	Bioorganic & medicinal chemistry letters, Apr-15, Volume: 20, Issue:8	Enhanced Nrf2-dependent induction of glutathione in mouse embryonic fibroblasts by isoselenocyanate analog of sulforaphane.
AID1418258	Induction of apoptosis in human SMMC7721 cells assessed as late apoptotic cells at 4 uM after 72 hrs by Alexa Fluor 488 Annexin/propidium iodide staining-based flow cytometric analysis (Rvb = 0.62%)	2018	European journal of medicinal chemistry, Sep-05, Volume: 157	Design, synthesis and biological evaluation of novel carbamodithioates as anti-proliferative agents against human cancer cells.
AID334285	Chemoprevention index, ratio of IC50 for mouse Hepa-1c1c7 cells to drug level required to induce 4-fold increase in quinone reductase activity in mouse Hepa-1c1c7 cells	2002	Journal of natural products, May, Volume: 65, Issue:5	Induction of quinone reductase by withanolides.
AID773886	Induction of Nrf2-mediated ARE activity in human HepG2-ARE-C8 cells at 10 uM after 12 hrs by luciferase reporter gene assay relative to control	2013	Journal of medicinal chemistry, Oct-24, Volume: 56, Issue:20	3-aroylmethylene-2,3,6,7-tetrahydro-1H-pyrazino[2,1-a]isoquinolin-4(11bH)-ones as potent Nrf2/ARE inducers in human cancer cells and AOM-DSS treated mice.
AID334057	Induction of quinone reductase activity in mouse Hepa-1c1c7 cells assessed as drug level required to double enzyme activity after 48 hrs by MTT assay	1997	Journal of natural products, Sep, Volume: 60, Issue:9	Activity-guided isolation of constituents of Tephrosia purpurea with the potential to induce the phase II enzyme, quinone reductase.
AID1377162	Induction of quinone reductase activity in mouse Hepa1c1c7 cells at 2 uM using menadione/NADP as substrate after 24 hrs by MTT assay relative to control	2017	Journal of natural products, 06-23, Volume: 80, Issue:6	Botrysphones A-C and Botrysphins A-F, Triketides and Diterpenoids from the Fungus Botrysphaeria laricina.
AID380748	Induction of NADPH:quinone reductase activity in mouse Hepa-1c1c7 cells assessed as drug level required to double specific enzyme activity	2006	Journal of natural products, Mar, Volume: 69, Issue:3	Quinone reductase induction as a biomarker for cancer chemoprevention.
AID417762	Ratio of induction of CYP1 activity to induction of NQO1 activity in mouse Hepa-1c1c7 cells at 1 uM after 48 hrs	2009	Bioorganic & medicinal chemistry, Mar-01, Volume: 17, Issue:5	Functionalized 3-benzylidene-indolin-2-ones: inducers of NAD(P)H-quinone oxidoreductase 1 (NQO1) with antiproliferative activity.
AID436109	Cell cycle arrest in human LTEP-A2 cells assessed as accumulation at S phase at 6.25 uM after 24 hrs by flow cytometry	2008	Journal of natural products, Nov, Volume: 71, Issue:11	Sulforaphane induces cell-cycle arrest and apoptosis in cultured human lung adenocarcinoma LTEP-A2 cells and retards growth of LTEP-A2 xenografts in vivo.
AID1536350	Kinetic solubility of the compound at pH 7.4 by CLND method	2019	Bioorganic & medicinal chemistry, 02-15, Volume: 27, Issue:4	Discovery of a crystalline sulforaphane analog with good solid-state stability and engagement of the Nrf2 pathway in vitro and in vivo.
AID1474564	Induction of apoptosis in human LoVo/DX cells assessed as late apoptotic cells at 15 uM after 24 hrs by APC-Annexin-V/propidium iodide staining based flow cytometric method relative to control	2017	European journal of medicinal chemistry, May-26, Volume: 132	Novel phosphonate analogs of sulforaphane: Synthesis, in vitro and in vivo anticancer activity.
AID1474563	Induction of apoptosis in human LoVo cells assessed as late apoptotic cells at 15 uM after 24 hrs by APC-Annexin-V/propidium iodide staining based flow cytometric method relative to control	2017	European journal of medicinal chemistry, May-26, Volume: 132	Novel phosphonate analogs of sulforaphane: Synthesis, in vitro and in vivo anticancer activity.
AID640731	Cytotoxicity against human Jurkat T cells assessed as decrease in cell viability after 24 hrs by flow cytometric analysis	2012	European journal of medicinal chemistry, Feb, Volume: 48	Design, synthesis and biological evaluation of new naphtalene diimides bearing isothiocyanate functionality.
AID1579153	Antiproliferative activity against human NCI-H1975 cells assessed as inhibition of cell viability after 72 hrs by CCK-8 assay	2019	European journal of medicinal chemistry, Nov-01, Volume: 181	Novel cyclin-dependent kinase 9 (CDK9) inhibitor with suppression of cancer stemness activity against non-small-cell lung cancer.
AID436116	Cell cycle arrest in human LTEP-A2 cells assessed as accumulation at G0/G1 phase at 50 uM after 3 hrs by flow cytometry	2008	Journal of natural products, Nov, Volume: 71, Issue:11	Sulforaphane induces cell-cycle arrest and apoptosis in cultured human lung adenocarcinoma LTEP-A2 cells and retards growth of LTEP-A2 xenografts in vivo.
AID707930	Cytotoxicity against human DU145 cells incubated for 24 hrs by WST1 dye reduction assay	2012	Journal of medicinal chemistry, Nov-26, Volume: 55, Issue:22	Enhanced in vitro biological activity of synthetic 2-(2-pyridyl) ethyl isothiocyanate compared to natural 4-(methylsulfinyl) butyl isothiocyanate.
AID1373846	Drug level in HEPES buffer at pH 7.4 treated with 2-(2-(2-(dimethylamino)ethoxy)ethoxy)ethyl 4-(methylsulfinyl)butylcarbamodithioate assessed as active compound formation measured up to 30 hrs by HPLC method	2018	Bioorganic & medicinal chemistry letters, 02-15, Volume: 28, Issue:4	Therapeutic effects of isothiocyanate prodrugs on rheumatoid arthritis.
AID692238	Induction of p53 G245C mutant depletion in human NCI-H596 cells at 60 uM incubated for 2 hrs by immunoblot analysis	2011	Journal of medicinal chemistry, Feb-10, Volume: 54, Issue:3	Selective depletion of mutant p53 by cancer chemopreventive isothiocyanates and their structure-activity relationships.
AID1765445	Inhibition of Keap1-Nrf2 interaction in mouse peritoneal macrophages assessed as upregulation of HO-1 protein expression at 10 uM by Western blot analysis	2021	European journal of medicinal chemistry, Oct-15, Volume: 222	Structure-based molecular hybridization design of Keap1-Nrf2 inhibitors as novel protective agents of acute lung injury.
AID1657374	Activation of Nrf2 in human MDA-MB-231 cells assessed as increase in NQO1 protein level at 2 uM incubated for 16 hrs by immunoblot analysis	2020	Journal of natural products, 04-24, Volume: 83, Issue:4	4β-Hydroxywithanolide E from Goldenberry (Whole Fruits of
AID1579175	Induction of apoptosis in human A549 cells assessed as viable cells at 1 uM after 48 hrs by AnnexinV-FITC/PI staining-based flow cytometric analysis (Rvb = 88.8%)	2019	European journal of medicinal chemistry, Nov-01, Volume: 181	Novel cyclin-dependent kinase 9 (CDK9) inhibitor with suppression of cancer stemness activity against non-small-cell lung cancer.
AID417740	Induction of NQO1 activity in mouse Hepa-1c1c7 cells assessed as drug level required to double basal enzyme activity after 48 hrs by MTT assay	2009	Bioorganic & medicinal chemistry, Mar-01, Volume: 17, Issue:5	Functionalized 3-benzylidene-indolin-2-ones: inducers of NAD(P)H-quinone oxidoreductase 1 (NQO1) with antiproliferative activity.
AID356395	Induction of NADPH:quinone reductase in mouse Hepa-1c1c7 cells assessed as drug level required to double enzyme activity by MTT assay	2003	Journal of natural products, Sep, Volume: 66, Issue:9	Potential cncer chemopreventive flavonoids from the stems of Tephrosia toxicaria.
AID356303	Induction of NADPH:quinone reductase activity in mouse Hepa-1c1c7 cells assessed as drug level required to double specific enzyme activity	2003	Journal of natural products, Aug, Volume: 66, Issue:8	Isolation and characterization of miscellaneous secondary metabolites of Deprea subtriflora.
AID1676347	Inhibition of Keap1-Nrf2 protein-protein interaction in human HepG2-ARE-C8 cells assessed as Nrf2 activation mediated ARE-driven luciferase activity by measuring fold change at 0.1 uM measured after 12 hrs by luciferase reporter gene assay	2020	Journal of medicinal chemistry, 10-08, Volume: 63, Issue:19	Design, Synthesis, and Structure-Activity Relationships of Indoline-Based Kelch-like ECH-Associated Protein 1-Nuclear Factor (Erythroid-Derived 2)-Like 2 (Keap1-Nrf2) Protein-Protein Interaction Inhibitors.
AID1252697	Inhibition of recombinant human SHP2 catalytic domain (246 to 527 amino acid residues) in 3,3-dimethylglutarate buffer using pNPP as substrate assessed as p-nitrophenolate release by spectrophotometric analysis in presence of reversible, site-directed inh	2015	Bioorganic & medicinal chemistry letters, Oct-15, Volume: 25, Issue:20	Inactivation of protein tyrosine phosphatases by dietary isothiocyanates.
AID1536346	Binding affinity to FLAG/His-tagged Keap1 (unknown origin)/biotinylated full-length FLAG/His/Tev/Avi-tagged NRF2 (unknown origin) expressed in baculovirus infected Sf9 insect cells measured after 1 hr by TR-FRET assay	2019	Bioorganic & medicinal chemistry, 02-15, Volume: 27, Issue:4	Discovery of a crystalline sulforaphane analog with good solid-state stability and engagement of the Nrf2 pathway in vitro and in vivo.
AID436126	Cell cycle arrest in human LTEP-A2 cells assessed as accumulation at G2/M phase at 50 uM after 48 hrs by flow cytometry	2008	Journal of natural products, Nov, Volume: 71, Issue:11	Sulforaphane induces cell-cycle arrest and apoptosis in cultured human lung adenocarcinoma LTEP-A2 cells and retards growth of LTEP-A2 xenografts in vivo.
AID773883	Induction of Nrf2-mediated ARE activity in human HepG2-ARE-C8 cells at 20 uM after 12 hrs by luciferase reporter gene assay relative to control	2013	Journal of medicinal chemistry, Oct-24, Volume: 56, Issue:20	3-aroylmethylene-2,3,6,7-tetrahydro-1H-pyrazino[2,1-a]isoquinolin-4(11bH)-ones as potent Nrf2/ARE inducers in human cancer cells and AOM-DSS treated mice.
AID606613	Induction of Nrf2-mediated NQO1 gene expression in human BEAS2B cells at 10 uM after 16 hrs by RT-PCR analysis relative to untreated control	2011	Journal of medicinal chemistry, Jun-23, Volume: 54, Issue:12	Novel chalcone derivatives as potent Nrf2 activators in mice and human lung epithelial cells.
AID436115	Cell cycle arrest in human LTEP-A2 cells assessed as accumulation at G2/M phase at 6.25 uM after 72 hrs by flow cytometry	2008	Journal of natural products, Nov, Volume: 71, Issue:11	Sulforaphane induces cell-cycle arrest and apoptosis in cultured human lung adenocarcinoma LTEP-A2 cells and retards growth of LTEP-A2 xenografts in vivo.
AID1252705	Reversible inhibition of recombinant human PTP1B catalytic domain (1 to 322 amino acid residues) in 3,3-dimethylglutarate buffer assessed as inactivation constant kr	2015	Bioorganic & medicinal chemistry letters, Oct-15, Volume: 25, Issue:20	Inactivation of protein tyrosine phosphatases by dietary isothiocyanates.
AID436145	Antiproliferative activity against human LS 174T cells	2008	Journal of natural products, Nov, Volume: 71, Issue:11	Sulforaphane induces cell-cycle arrest and apoptosis in cultured human lung adenocarcinoma LTEP-A2 cells and retards growth of LTEP-A2 xenografts in vivo.
AID476692	Induction of NrF2-mediated glutathione production in wild type MEF at 20 uM after 24 hrs using Elmans reagent relative to control	2010	Bioorganic & medicinal chemistry letters, Apr-15, Volume: 20, Issue:8	Enhanced Nrf2-dependent induction of glutathione in mouse embryonic fibroblasts by isoselenocyanate analog of sulforaphane.
AID679184	TP_TRANSPORTER: Northern blot in vitro, primary rat hepatocyte	2001	Biochemical and biophysical research communications, Mar-23, Volume: 282, Issue:1	Reactive oxygen species-related induction of multidrug resistance-associated protein 2 expression in primary hepatocytes exposed to sulforaphane.
AID496817	Antimicrobial activity against Trypanosoma cruzi	2010	Bioorganic & medicinal chemistry, Mar-15, Volume: 18, Issue:6	Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species.
AID692266	Induction of apoptosis in human MDA-MB-231 cells expressing p53 R280K mutant at 10 uM incubated for 24 hrs by FITC/Annexin-V staining method	2011	Journal of medicinal chemistry, Feb-10, Volume: 54, Issue:3	Selective depletion of mutant p53 by cancer chemopreventive isothiocyanates and their structure-activity relationships.
AID1418245	Antiproliferative activity against human A375 cells assessed as inhibition of cell proliferation at 32 uM after 72 hrs by CCK8 assay	2018	European journal of medicinal chemistry, Sep-05, Volume: 157	Design, synthesis and biological evaluation of novel carbamodithioates as anti-proliferative agents against human cancer cells.
AID1418266	Cell cycle arrest in human SMMC7721 cells assessed as accumulation at S phase at 4 uM after 72 hrs by RNase/propidium iodide staining-based flow cytometric analysis (Rvb = 7.96%)	2018	European journal of medicinal chemistry, Sep-05, Volume: 157	Design, synthesis and biological evaluation of novel carbamodithioates as anti-proliferative agents against human cancer cells.
AID436106	Cell cycle arrest in human LTEP-A2 cells assessed as accumulation at G0/G1 phase at 6.25 uM after 48 hrs by flow cytometry	2008	Journal of natural products, Nov, Volume: 71, Issue:11	Sulforaphane induces cell-cycle arrest and apoptosis in cultured human lung adenocarcinoma LTEP-A2 cells and retards growth of LTEP-A2 xenografts in vivo.
AID1252695	Inhibition of recombinant human SHP2 catalytic domain (246 to 527 amino acid residues) in Tris buffer using pNPP as substrate assessed as apparent second order rate constant after 10 mins	2015	Bioorganic & medicinal chemistry letters, Oct-15, Volume: 25, Issue:20	Inactivation of protein tyrosine phosphatases by dietary isothiocyanates.
AID1243386	Toxicity against mouse Hepa-1c1c7 cells assessed as inhibition of cell proliferation	2015	Bioorganic & medicinal chemistry letters, Sep-15, Volume: 25, Issue:18	Identification of dialkyl diacetylene diols with potent cancer chemopreventive activity.
AID490157	Induction of human NQO1 activity in mouse Hepa-1c1c7 cells at 5 uM after 48 hrs relative to control	2010	European journal of medicinal chemistry, Jul, Volume: 45, Issue:7	Functionalized aurones as inducers of NAD(P)H:quinone oxidoreductase 1 that activate AhR/XRE and Nrf2/ARE signaling pathways: synthesis, evaluation and SAR.
AID1826663	Inhibition of human recombinant MAO-A by fluorescence assay	2022	Journal of medicinal chemistry, 03-24, Volume: 65, Issue:6	Resveratrol-Based MTDLs to Stimulate Defensive and Regenerative Pathways and Block Early Events in Neurodegenerative Cascades.
AID1579156	Antiproliferative activity against human MCF7 cells assessed as inhibition of cell viability after 72 hrs by CCK-8 assay	2019	European journal of medicinal chemistry, Nov-01, Volume: 181	Novel cyclin-dependent kinase 9 (CDK9) inhibitor with suppression of cancer stemness activity against non-small-cell lung cancer.
AID1474561	Induction of apoptosis in human LoVo cells assessed as loss of mitochondrial membrane potential at 15 uM after 24 hrs by JC-1 staining based flow cytometric method relative to control	2017	European journal of medicinal chemistry, May-26, Volume: 132	Novel phosphonate analogs of sulforaphane: Synthesis, in vitro and in vivo anticancer activity.
AID1219961	Cytoprotective activity against mouse fibroblasts assessed as reduction in GSH level at 3 uM after 2 to 4 hrs relative to control	2012	Drug metabolism and disposition: the biological fate of chemicals, Apr, Volume: 40, Issue:4	Metabolism of [6]-shogaol in mice and in cancer cells.
AID1418267	Cell cycle arrest in human SMMC7721 cells assessed as accumulation at G2/M phase at 4 uM after 72 hrs by RNase/propidium iodide staining-based flow cytometric analysis (Rvb = 24.78%)	2018	European journal of medicinal chemistry, Sep-05, Volume: 157	Design, synthesis and biological evaluation of novel carbamodithioates as anti-proliferative agents against human cancer cells.
AID1579176	Induction of apoptosis in human A549 cells assessed as early apoptotic cells at 1 uM after 48 hrs by AnnexinV-FITC/PI staining-based flow cytometric analysis (Rvb = 2.91%)	2019	European journal of medicinal chemistry, Nov-01, Volume: 181	Novel cyclin-dependent kinase 9 (CDK9) inhibitor with suppression of cancer stemness activity against non-small-cell lung cancer.
AID436114	Cell cycle arrest in human LTEP-A2 cells assessed as accumulation at G2/M phase at 6.25 uM after 48 hrs by flow cytometry	2008	Journal of natural products, Nov, Volume: 71, Issue:11	Sulforaphane induces cell-cycle arrest and apoptosis in cultured human lung adenocarcinoma LTEP-A2 cells and retards growth of LTEP-A2 xenografts in vivo.
AID1128078	Inhibition of Keap1-Nrf2 interaction in human HepG2-ARE-C8 cells assessed as activation of Nrf2-ARE luciferase activity at 20 uM after 12 hrs relative to control	2014	Journal of medicinal chemistry, Mar-27, Volume: 57, Issue:6	Discovery of potent Keap1-Nrf2 protein-protein interaction inhibitor based on molecular binding determinants analysis.
AID1373845	Drug level in HEPES buffer at pH 7.4 treated with 2-(2-(2-(dimethylamino)ethoxy)ethoxy)ethyl 4-(methylsulfinyl)butylcarbamodithioate assessed as active compound formation measured at 1 hr by HPLC method	2018	Bioorganic & medicinal chemistry letters, 02-15, Volume: 28, Issue:4	Therapeutic effects of isothiocyanate prodrugs on rheumatoid arthritis.
AID1579159	Antiproliferative activity against human Hep3B cells assessed as inhibition of cell viability after 72 hrs by CCK-8 assay	2019	European journal of medicinal chemistry, Nov-01, Volume: 181	Novel cyclin-dependent kinase 9 (CDK9) inhibitor with suppression of cancer stemness activity against non-small-cell lung cancer.
AID754026	Cytotoxicity against human A549 cells after 72 hrs by MTT assay	2013	European journal of medicinal chemistry, Jun, Volume: 64	Synthesis and biological evaluation of sulforaphane derivatives as potential antitumor agents.
AID1339465	Activation of Nrf2 (unknown origin) expressed in human HepG2 cells after 5 hrs by ARE-driven luciferase reporter gene assay	2017	Bioorganic & medicinal chemistry, 02-15, Volume: 25, Issue:4	Activation of anti-oxidant Nrf2 signaling by substituted trans stilbenes.
AID1418247	Antiproliferative activity against human SMMC7721 cells assessed as inhibition of cell proliferation at 32 uM after 72 hrs by CCK8 assay	2018	European journal of medicinal chemistry, Sep-05, Volume: 157	Design, synthesis and biological evaluation of novel carbamodithioates as anti-proliferative agents against human cancer cells.
AID436122	Cell cycle arrest in human LTEP-A2 cells assessed as accumulation at S phase at 50 uM after 48 hrs by flow cytometry	2008	Journal of natural products, Nov, Volume: 71, Issue:11	Sulforaphane induces cell-cycle arrest and apoptosis in cultured human lung adenocarcinoma LTEP-A2 cells and retards growth of LTEP-A2 xenografts in vivo.
AID1765439	Cytotoxicity against mouse peritoneal macrophages assessed as reduction in cell viability measured after 24 hrs by CCK8 assay	2021	European journal of medicinal chemistry, Oct-15, Volume: 222	Structure-based molecular hybridization design of Keap1-Nrf2 inhibitors as novel protective agents of acute lung injury.
AID436147	Antitumor activity against human LTEP-A2 cells xenografted in athymic mouse assessed as reduction in wet tumor weight at 50 mg/kg, ip administered 3 times per week measured after 9 days relative to control	2008	Journal of natural products, Nov, Volume: 71, Issue:11	Sulforaphane induces cell-cycle arrest and apoptosis in cultured human lung adenocarcinoma LTEP-A2 cells and retards growth of LTEP-A2 xenografts in vivo.
AID1418261	Induction of apoptosis in human SMMC7721 cells assessed as necrotic cells at 8 uM after 72 hrs by Alexa Fluor 488 Annexin/propidium iodide staining-based flow cytometric analysis (Rvb = 6.76%)	2018	European journal of medicinal chemistry, Sep-05, Volume: 157	Design, synthesis and biological evaluation of novel carbamodithioates as anti-proliferative agents against human cancer cells.
AID1248053	Activation of Nrf2 in mouse Hepa1c1c7 cells assessed as concentration required to 2 fold induction of NQO1 production after 24 hrs by MTT colorimetric assay	2015	Journal of medicinal chemistry, Sep-24, Volume: 58, Issue:18	Design, Synthesis, and Evaluation of Triazole Derivatives That Induce Nrf2 Dependent Gene Products and Inhibit the Keap1-Nrf2 Protein-Protein Interaction.
AID707937	Increase in apoptosis gene expression in human PC3 cells at 10 uM incubated for 8 hrs by Affymetrix human exon array relative to untreated control	2012	Journal of medicinal chemistry, Nov-26, Volume: 55, Issue:22	Enhanced in vitro biological activity of synthetic 2-(2-pyridyl) ethyl isothiocyanate compared to natural 4-(methylsulfinyl) butyl isothiocyanate.
AID1377166	Cytotoxicity against mouse Hepa1c1c7 cells assessed as reduction in cell viability at 2 uM by MTT assay	2017	Journal of natural products, 06-23, Volume: 80, Issue:6	Botrysphones A-C and Botrysphins A-F, Triketides and Diterpenoids from the Fungus Botrysphaeria laricina.
AID436118	Cell cycle arrest in human LTEP-A2 cells assessed as accumulation at G0/G1 phase at 50 uM after 48 hrs by flow cytometry	2008	Journal of natural products, Nov, Volume: 71, Issue:11	Sulforaphane induces cell-cycle arrest and apoptosis in cultured human lung adenocarcinoma LTEP-A2 cells and retards growth of LTEP-A2 xenografts in vivo.
AID1676348	Inhibition of Keap1-Nrf2 protein-protein interaction in human HepG2-ARE-C8 cells assessed as Nrf2 activation mediated ARE-driven luciferase activity by measuring fold change at 1 uM measured after 12 hrs by luciferase reporter gene assay	2020	Journal of medicinal chemistry, 10-08, Volume: 63, Issue:19	Design, Synthesis, and Structure-Activity Relationships of Indoline-Based Kelch-like ECH-Associated Protein 1-Nuclear Factor (Erythroid-Derived 2)-Like 2 (Keap1-Nrf2) Protein-Protein Interaction Inhibitors.
AID476694	Reduction of NrF2-mediated glutathione production in wild type MEF at 10 uM after 6 hrs using Elmans reagent relative to control	2010	Bioorganic & medicinal chemistry letters, Apr-15, Volume: 20, Issue:8	Enhanced Nrf2-dependent induction of glutathione in mouse embryonic fibroblasts by isoselenocyanate analog of sulforaphane.
AID436132	Induction of apoptosis in human LTEP-A2 cells assessed as sub-G0/G1 DNA content at 50 uM after 3 hrs by propidium iodide based flow cytometry	2008	Journal of natural products, Nov, Volume: 71, Issue:11	Sulforaphane induces cell-cycle arrest and apoptosis in cultured human lung adenocarcinoma LTEP-A2 cells and retards growth of LTEP-A2 xenografts in vivo.
AID1400539	Activation of Nrf2 in mouse Heap1c1c7 cells assessed as induction of NAD(P)H:quinone reductase activity at 2 uM relative to control	2018	Bioorganic & medicinal chemistry, 10-01, Volume: 26, Issue:18	Discovery of natural flavonoids as activators of Nrf2-mediated defense system: Structure-activity relationship and inhibition of intracellular oxidative insults.
AID754023	Cytotoxicity against African green monkey Vero cells after 72 hrs by MTT assay	2013	European journal of medicinal chemistry, Jun, Volume: 64	Synthesis and biological evaluation of sulforaphane derivatives as potential antitumor agents.
AID1418252	Antiproliferative activity against human HeLa cells after 72 hrs by CCK8 assay	2018	European journal of medicinal chemistry, Sep-05, Volume: 157	Design, synthesis and biological evaluation of novel carbamodithioates as anti-proliferative agents against human cancer cells.
AID1248059	Increase of Nrf2 protein level in mouse Hepa1c1c7 cells at 10 uM after 1 hrs by Western blot analysis	2015	Journal of medicinal chemistry, Sep-24, Volume: 58, Issue:18	Design, Synthesis, and Evaluation of Triazole Derivatives That Induce Nrf2 Dependent Gene Products and Inhibit the Keap1-Nrf2 Protein-Protein Interaction.
AID754014	Induction of apoptosis in human HepG2 cells assessed as late apoptotic cells at 10 uM after 48 hrs by Annexin-V-FITC/propidium iodide staining-based flow cytometric analysis (Rvb = 0.29%)	2013	European journal of medicinal chemistry, Jun, Volume: 64	Synthesis and biological evaluation of sulforaphane derivatives as potential antitumor agents.
AID436113	Cell cycle arrest in human LTEP-A2 cells assessed as accumulation at G2/M phase at 6.25 uM after 24 hrs by flow cytometry	2008	Journal of natural products, Nov, Volume: 71, Issue:11	Sulforaphane induces cell-cycle arrest and apoptosis in cultured human lung adenocarcinoma LTEP-A2 cells and retards growth of LTEP-A2 xenografts in vivo.
AID480523	Induction of NQO1 activity in human HEL cells at 5 uM after 24 to 48 hrs by fluorescence plate reader	2010	Bioorganic & medicinal chemistry, May-01, Volume: 18, Issue:9	Antitumor activity and COMPARE analysis of bis-indole derivatives.
AID1474565	Induction of apoptosis in human LoVo cells assessed as increase in early apoptotic cells at 15 uM after 24 hrs by APC-Annexin-V/propidium iodide staining based flow cytometric method relative to control	2017	European journal of medicinal chemistry, May-26, Volume: 132	Novel phosphonate analogs of sulforaphane: Synthesis, in vitro and in vivo anticancer activity.
AID1054581	Activity at recombinant human MAO-A expressed in baculovirus infected BT1 cells assessed as residual activity using benzylamine as substrate at 20 uM preincubated for 30 mins by Amplex Red assay relative to control	2013	European journal of medicinal chemistry, , Volume: 70	Novel polyamine analogues: from substrates towards potential inhibitors of monoamine oxidases.
AID436138	Antitumor activity against human LTEP-A2 cells xenografted in athymic mouse assessed as tumor growth inhibition	2008	Journal of natural products, Nov, Volume: 71, Issue:11	Sulforaphane induces cell-cycle arrest and apoptosis in cultured human lung adenocarcinoma LTEP-A2 cells and retards growth of LTEP-A2 xenografts in vivo.
AID380752	Induction of antioxidant response element activity in human HepG2 cells at 10 uM by luciferase based chemiluminescence assay	2006	Journal of natural products, Mar, Volume: 69, Issue:3	Quinone reductase induction as a biomarker for cancer chemoprevention.
AID707920	Increase in toll-like receptor signaling pathway related gene expression in human PNT1A cells at 10 uM incubated for 8 hrs by Affymetrix human exon array relative to untreated control	2012	Journal of medicinal chemistry, Nov-26, Volume: 55, Issue:22	Enhanced in vitro biological activity of synthetic 2-(2-pyridyl) ethyl isothiocyanate compared to natural 4-(methylsulfinyl) butyl isothiocyanate.
AID436123	Cell cycle arrest in human LTEP-A2 cells assessed as accumulation at S phase at 50 uM after 72 hrs by flow cytometry	2008	Journal of natural products, Nov, Volume: 71, Issue:11	Sulforaphane induces cell-cycle arrest and apoptosis in cultured human lung adenocarcinoma LTEP-A2 cells and retards growth of LTEP-A2 xenografts in vivo.
AID1373853	Drug level in mouse plasma treated with 2-(2-(2-(dimethylamino)ethoxy)ethoxy)ethyl 4-(methylsulfinyl)butylcarbamodithioate assessed as active compound formation measured after 24 hrs by HPLC method	2018	Bioorganic & medicinal chemistry letters, 02-15, Volume: 28, Issue:4	Therapeutic effects of isothiocyanate prodrugs on rheumatoid arthritis.
AID481439	Absolute bioavailability in human	2010	Journal of medicinal chemistry, May-13, Volume: 53, Issue:9	How well can the Caco-2/Madin-Darby canine kidney models predict effective human jejunal permeability?
AID1252703	Chemical stability of the compound in Bis-Tris and Tris buffer containing DTPA, sodium acetate, Tween 80 at pH 7.0 at 30 degC incubated for 2.5 hrs prior to addition of PTP1B	2015	Bioorganic & medicinal chemistry letters, Oct-15, Volume: 25, Issue:20	Inactivation of protein tyrosine phosphatases by dietary isothiocyanates.
AID707932	Cytotoxicity against human Caco2 cells incubated for 24 hrs by WST1 dye reduction assay	2012	Journal of medicinal chemistry, Nov-26, Volume: 55, Issue:22	Enhanced in vitro biological activity of synthetic 2-(2-pyridyl) ethyl isothiocyanate compared to natural 4-(methylsulfinyl) butyl isothiocyanate.
AID1676351	Inhibition of Keap1-Nrf2 protein-protein interaction in human HepG2-ARE-C8 cells assessed as Nrf2 activation mediated ARE-driven luciferase activity by measuring fold change at 20 uM measured after 12 hrs by luciferase reporter gene assay	2020	Journal of medicinal chemistry, 10-08, Volume: 63, Issue:19	Design, Synthesis, and Structure-Activity Relationships of Indoline-Based Kelch-like ECH-Associated Protein 1-Nuclear Factor (Erythroid-Derived 2)-Like 2 (Keap1-Nrf2) Protein-Protein Interaction Inhibitors.
AID436134	Induction of apoptosis in human LTEP-A2 cells assessed as sub-G0/G1 DNA content at 50 uM after 48 hrs by propidium iodide based flow cytometry	2008	Journal of natural products, Nov, Volume: 71, Issue:11	Sulforaphane induces cell-cycle arrest and apoptosis in cultured human lung adenocarcinoma LTEP-A2 cells and retards growth of LTEP-A2 xenografts in vivo.
AID1303332	Inhibition of EGFR-TK in human A431 cell lysate assessed as reduction in EGF stimulated kinase activity after 60 mins using biotinylated peptide substrate by ELISA	2016	European journal of medicinal chemistry, Jul-19, Volume: 117	Combined inhibition of the EGFR/AKT pathways by a novel conjugate of quinazoline with isothiocyanate.
AID1054577	Cytotoxicity against human SH-SY5Y cells after 24 hrs by Annexin V-PE-based flow cytometry	2013	European journal of medicinal chemistry, , Volume: 70	Novel polyamine analogues: from substrates towards potential inhibitors of monoamine oxidases.
AID1226965	Activation of Keap1/Nrf2/ARE pathway in mouse Hepa-1c1c7 cells assessed as double induction of NQO1 specific activity after 48 hrs by bicinchoninic acid assay	2015	Journal of medicinal chemistry, Jun-11, Volume: 58, Issue:11	New Monocyclic, Bicyclic, and Tricyclic Ethynylcyanodienones as Activators of the Keap1/Nrf2/ARE Pathway and Inhibitors of Inducible Nitric Oxide Synthase.
AID692257	Induction of covalent cysteine modification at p53 G245C mutant in human NCI-H596 cells at 100 uM incubated for 1 hr by monochlorobimane fluorometric assay	2011	Journal of medicinal chemistry, Feb-10, Volume: 54, Issue:3	Selective depletion of mutant p53 by cancer chemopreventive isothiocyanates and their structure-activity relationships.
AID334282	Induction of quinone reductase activity in mouse Hepa-1c1c7 cells assessed as drug level required to induce 4-fold increase in enzyme activity after 48 hrs by NADPH-dependent MTT reduction assay	2002	Journal of natural products, May, Volume: 65, Issue:5	Induction of quinone reductase by withanolides.
AID436151	Toxicity in human PC3 cells xenografted in athymic mouse assessed as weight loss at 25 to 100 mg/kg, po administered 3 times per week	2008	Journal of natural products, Nov, Volume: 71, Issue:11	Sulforaphane induces cell-cycle arrest and apoptosis in cultured human lung adenocarcinoma LTEP-A2 cells and retards growth of LTEP-A2 xenografts in vivo.
AID436136	Cell cycle arrest in human LTEP-A2 cells assessed as accumulation at G2/M phase by flow cytometry	2008	Journal of natural products, Nov, Volume: 71, Issue:11	Sulforaphane induces cell-cycle arrest and apoptosis in cultured human lung adenocarcinoma LTEP-A2 cells and retards growth of LTEP-A2 xenografts in vivo.
AID1474556	Cell cycle arrest in human LoVo/DX cells assessed as accumulation at G2/M phase at >15 uM after 24 hrs by propidium iodide staining based flow cytometric method	2017	European journal of medicinal chemistry, May-26, Volume: 132	Novel phosphonate analogs of sulforaphane: Synthesis, in vitro and in vivo anticancer activity.
AID1534949	Activation of NRF2 in human U2OS cells co-expressing Keap1 assessed as induction of NRF2 translocation to nucleus after 6 hrs by beta-galactosidase based chemiluminescent assay	2019	Journal of medicinal chemistry, 01-24, Volume: 62, Issue:2	Optimization of Vinyl Sulfone Derivatives as Potent Nuclear Factor Erythroid 2-Related Factor 2 (Nrf2) Activators for Parkinson's Disease Therapy.
AID356416	Chemoprevention index, ratio of IC50 for mouse Hepa-1c1c7 cells to drug level required to double NADPH:quinone reductase activity in mouse Hepa-1c1c7 cells	2003	Journal of natural products, Sep, Volume: 66, Issue:9	Constituents of the stem bark of Pongamia pinnata with the potential to induce quinone reductase.
AID1657375	Activation of Nrf2 in human MDA-MB-231 cells assessed as increase in GCLM protein level at 2 uM incubated for 16 hrs by immunoblot analysis	2020	Journal of natural products, 04-24, Volume: 83, Issue:4	4β-Hydroxywithanolide E from Goldenberry (Whole Fruits of
AID1252691	Inhibition of recombinant human SHP2 catalytic domain (246 to 527 amino acid residues) in 3,3-dimethylglutarate buffer using pNPP as substrate assessed as apparent second order rate constant after 10 mins	2015	Bioorganic & medicinal chemistry letters, Oct-15, Volume: 25, Issue:20	Inactivation of protein tyrosine phosphatases by dietary isothiocyanates.
AID1418250	Antiproliferative activity against human A375 cells after 72 hrs by CCK8 assay	2018	European journal of medicinal chemistry, Sep-05, Volume: 157	Design, synthesis and biological evaluation of novel carbamodithioates as anti-proliferative agents against human cancer cells.
AID1418244	Antiproliferative activity against human A375 cells assessed as inhibition of cell proliferation at 16 uM after 72 hrs by CCK8 assay	2018	European journal of medicinal chemistry, Sep-05, Volume: 157	Design, synthesis and biological evaluation of novel carbamodithioates as anti-proliferative agents against human cancer cells.
AID1474557	Induction of apoptosis in human LoVo/DX cells assessed as increase in caspase3/7 activity at 15 uM using Ac-DEVD-ACC as substrate pretreated for 24 hrs followed by substrate addition measured for 2 hrs by fluorescence assay relative to control	2017	European journal of medicinal chemistry, May-26, Volume: 132	Novel phosphonate analogs of sulforaphane: Synthesis, in vitro and in vivo anticancer activity.
AID1765442	Antiinflammatory activity against mouse peritoneal macrophages assessed as reduction in LPS-induced TNFalpha production at 10 uM measured after 24 hrs by ELISA	2021	European journal of medicinal chemistry, Oct-15, Volume: 222	Structure-based molecular hybridization design of Keap1-Nrf2 inhibitors as novel protective agents of acute lung injury.
AID355763	Induction of quinone reductase activity in mouse Hepa-1c1c7 cells assessed as drug level required to double enzyme activity	2003	Journal of natural products, May, Volume: 66, Issue:5	Potential cancer chemopreventive constituents of the seeds of Dipteryx odorata (tonka bean).
AID356394	Chemoprevention index, ratio of IC50 for mouse Hepa-1c1c7 cells to drug level required to double NADPH:quinone reductase activity in mouse Hepa-1c1c7 cells	2003	Journal of natural products, Sep, Volume: 66, Issue:9	Potential cncer chemopreventive flavonoids from the stems of Tephrosia toxicaria.
AID1657398	Activation of Nrf2 in human BEAS2B cells harboring Keap1-C151S mutant assessed as increase in Nrf2 protein expression at 2 uM after12 hrs in presence of Keap1-siRNA by immunoblot analysis	2020	Journal of natural products, 04-24, Volume: 83, Issue:4	4β-Hydroxywithanolide E from Goldenberry (Whole Fruits of
AID490163	Induction of Ah receptor in mouse Hepa-1c1c7 cells assessed as induction of CYP1A1 activity at 1 uM after 48 hrs by EROD assay relative to control	2010	European journal of medicinal chemistry, Jul, Volume: 45, Issue:7	Functionalized aurones as inducers of NAD(P)H:quinone oxidoreductase 1 that activate AhR/XRE and Nrf2/ARE signaling pathways: synthesis, evaluation and SAR.
AID773887	Induction of Nrf2-mediated ARE activity in human HepG2-ARE-C8 cells at 5 uM after 12 hrs by luciferase reporter gene assay relative to control	2013	Journal of medicinal chemistry, Oct-24, Volume: 56, Issue:20	3-aroylmethylene-2,3,6,7-tetrahydro-1H-pyrazino[2,1-a]isoquinolin-4(11bH)-ones as potent Nrf2/ARE inducers in human cancer cells and AOM-DSS treated mice.
AID754020	Cell cycle arrest in human HepG2 cells assessed as accumulation at G2/M phase at 5 to 20 uM after 48 hrs by DAPI staining-based flow cytometric analysis	2013	European journal of medicinal chemistry, Jun, Volume: 64	Synthesis and biological evaluation of sulforaphane derivatives as potential antitumor agents.
AID707925	Induction of p21 protein expression in human PNT1A cells at 10 uM incubated for 8 hrs by Western blotting	2012	Journal of medicinal chemistry, Nov-26, Volume: 55, Issue:22	Enhanced in vitro biological activity of synthetic 2-(2-pyridyl) ethyl isothiocyanate compared to natural 4-(methylsulfinyl) butyl isothiocyanate.
AID1826670	Activation of Nrf2 in human Arec32 cells assessed as concentration required to double luciferase activity measured after 24 hrs	2022	Journal of medicinal chemistry, 03-24, Volume: 65, Issue:6	Resveratrol-Based MTDLs to Stimulate Defensive and Regenerative Pathways and Block Early Events in Neurodegenerative Cascades.
AID1248065	Cytotoxicity against mouse Hepa1c1c7 cells assessed as cell viability at 10 to 30 uM after 24 to 48 hrs by SRB assay	2015	Journal of medicinal chemistry, Sep-24, Volume: 58, Issue:18	Design, Synthesis, and Evaluation of Triazole Derivatives That Induce Nrf2 Dependent Gene Products and Inhibit the Keap1-Nrf2 Protein-Protein Interaction.
AID356393	Inhibition of mouse Hepa-1c1c7 cells by MTT assay	2003	Journal of natural products, Sep, Volume: 66, Issue:9	Potential cncer chemopreventive flavonoids from the stems of Tephrosia toxicaria.
AID1577830	Binding affinity to Keap1 in mouse Hepa1c1c7 cells assessed as reduction in Keap1 interaction by measuring induction of NQO1 activity at 10 uM in 1.4% DMSO measured after 24 hrs	2019	Journal of medicinal chemistry, 09-12, Volume: 62, Issue:17	A Comparative Assessment Study of Known Small-Molecule Keap1-Nrf2 Protein-Protein Interaction Inhibitors: Chemical Synthesis, Binding Properties, and Cellular Activity.
AID773884	Induction of Nrf2-mediated ARE activity in human HepG2-ARE-C8 cells at 12.5 uM after 12 hrs by luciferase reporter gene assay relative to control	2013	Journal of medicinal chemistry, Oct-24, Volume: 56, Issue:20	3-aroylmethylene-2,3,6,7-tetrahydro-1H-pyrazino[2,1-a]isoquinolin-4(11bH)-ones as potent Nrf2/ARE inducers in human cancer cells and AOM-DSS treated mice.
AID436148	Antitumor activity against human PC3 cells xenografted in athymic mouse at 50 mg/kg, po administered 3 times per week by Western blot assay relative to control	2008	Journal of natural products, Nov, Volume: 71, Issue:11	Sulforaphane induces cell-cycle arrest and apoptosis in cultured human lung adenocarcinoma LTEP-A2 cells and retards growth of LTEP-A2 xenografts in vivo.
AID1713570	Cytotoxicity against mouse Hepa1c1c7 cells	2016	Bioorganic & medicinal chemistry letters, 10-15, Volume: 26, Issue:20	Systemic structure-activity relationship study of phenyl polyyne diols as potential chemopreventive agents.
AID436104	Cell cycle arrest in human LTEP-A2 cells assessed as accumulation at G0/G1 phase at 6.25 uM after 3 hrs by flow cytometry	2008	Journal of natural products, Nov, Volume: 71, Issue:11	Sulforaphane induces cell-cycle arrest and apoptosis in cultured human lung adenocarcinoma LTEP-A2 cells and retards growth of LTEP-A2 xenografts in vivo.
AID1766619	Induction of quinone reductase activity in mouse Hepa1c1c7 cells at 2 uM incubated for 24 hrs and assessed as maximum fold change by MTT based assay relative to control	2021	Journal of natural products, 04-23, Volume: 84, Issue:4	Terpenoids from Chinese Liverworts
AID707921	Increase in apoptosis related gene expression in human PNT1A cells at 10 uM incubated for 8 hrs by Affymetrix human exon array relative to untreated control	2012	Journal of medicinal chemistry, Nov-26, Volume: 55, Issue:22	Enhanced in vitro biological activity of synthetic 2-(2-pyridyl) ethyl isothiocyanate compared to natural 4-(methylsulfinyl) butyl isothiocyanate.
AID436135	Induction of apoptosis in human LTEP-A2 cells assessed as sub-G0/G1 DNA content at 50 uM after 72 hrs by propidium iodide based flow cytometry	2008	Journal of natural products, Nov, Volume: 71, Issue:11	Sulforaphane induces cell-cycle arrest and apoptosis in cultured human lung adenocarcinoma LTEP-A2 cells and retards growth of LTEP-A2 xenografts in vivo.
AID1303342	Inhibition of EGFR-TK in human A431 cell lysate assessed as reduction in EGF stimulated kinase activity at highest concentration after 60 mins using biotinylated peptide substrate by ELISA analysis	2016	European journal of medicinal chemistry, Jul-19, Volume: 117	Combined inhibition of the EGFR/AKT pathways by a novel conjugate of quinazoline with isothiocyanate.
AID1579168	Inhibition of colony formation in human H1299 cells at 1 uM after 12 days by crystal violet staining based assay	2019	European journal of medicinal chemistry, Nov-01, Volume: 181	Novel cyclin-dependent kinase 9 (CDK9) inhibitor with suppression of cancer stemness activity against non-small-cell lung cancer.
AID436120	Cell cycle arrest in human LTEP-A2 cells assessed as accumulation at S phase at 50 uM after 3 hrs by flow cytometry	2008	Journal of natural products, Nov, Volume: 71, Issue:11	Sulforaphane induces cell-cycle arrest and apoptosis in cultured human lung adenocarcinoma LTEP-A2 cells and retards growth of LTEP-A2 xenografts in vivo.
AID659237	Increase in intracellular GSH level in human MCF7 cells expressing antioxidant response element at 10 uM after 24 hrs by HPLC analysis in presence of GCL inhibitor buthionine sulfoximine	2012	Journal of medicinal chemistry, Feb-09, Volume: 55, Issue:3	A synthetic chalcone as a potent inducer of glutathione biosynthesis.
AID1579157	Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell viability after 72 hrs by CCK-8 assay	2019	European journal of medicinal chemistry, Nov-01, Volume: 181	Novel cyclin-dependent kinase 9 (CDK9) inhibitor with suppression of cancer stemness activity against non-small-cell lung cancer.
AID1579167	Inhibition of colony formation in human A549 cells at 1 uM after 12 days by crystal violet staining based assay	2019	European journal of medicinal chemistry, Nov-01, Volume: 181	Novel cyclin-dependent kinase 9 (CDK9) inhibitor with suppression of cancer stemness activity against non-small-cell lung cancer.
AID436110	Cell cycle arrest in human LTEP-A2 cells assessed as accumulation at S phase at 6.25 uM after 48 hrs by flow cytometry	2008	Journal of natural products, Nov, Volume: 71, Issue:11	Sulforaphane induces cell-cycle arrest and apoptosis in cultured human lung adenocarcinoma LTEP-A2 cells and retards growth of LTEP-A2 xenografts in vivo.
AID294478	Induction of quinone reductase activity in mouse Hepa 1c1c7 cells assessed as concentration required to double the enzyme activity	2007	European journal of medicinal chemistry, Jun, Volume: 42, Issue:6	Quinone reductase induction activity of methoxylated analogues of resveratrol.
AID1676350	Inhibition of Keap1-Nrf2 protein-protein interaction in human HepG2-ARE-C8 cells assessed as Nrf2 activation mediated ARE-driven luciferase activity by measuring fold change at 10 uM measured after 12 hrs by luciferase reporter gene assay	2020	Journal of medicinal chemistry, 10-08, Volume: 63, Issue:19	Design, Synthesis, and Structure-Activity Relationships of Indoline-Based Kelch-like ECH-Associated Protein 1-Nuclear Factor (Erythroid-Derived 2)-Like 2 (Keap1-Nrf2) Protein-Protein Interaction Inhibitors.
AID1698190	Induction of quinone reductase in mouse Hepa1c1c7 cells at 2 uM incubated for 24 hrs by MTT based assay	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Dolabellane and Clerodane Diterpenoids from the Twigs and Leaves of
AID1400566	Activation of Nrf2 in human BEAS2B cells assessed as upregulation of NQO1 protein expression at 2 uM after 12 hrs by immunoblot analysis	2018	Bioorganic & medicinal chemistry, 10-01, Volume: 26, Issue:18	Discovery of natural flavonoids as activators of Nrf2-mediated defense system: Structure-activity relationship and inhibition of intracellular oxidative insults.
AID1418257	Induction of apoptosis in human SMMC7721 cells assessed as necrotic cells at 4 uM after 72 hrs by Alexa Fluor 488 Annexin/propidium iodide staining-based flow cytometric analysis (Rvb = 6.76%)	2018	European journal of medicinal chemistry, Sep-05, Volume: 157	Design, synthesis and biological evaluation of novel carbamodithioates as anti-proliferative agents against human cancer cells.
AID707917	Increase in graft-versus-host disease related gene expression in human PNT1A cells at 10 uM incubated for 8 hrs by Affymetrix human exon array relative to untreated control	2012	Journal of medicinal chemistry, Nov-26, Volume: 55, Issue:22	Enhanced in vitro biological activity of synthetic 2-(2-pyridyl) ethyl isothiocyanate compared to natural 4-(methylsulfinyl) butyl isothiocyanate.
AID476675	Induction of nuclear NrF2 expression in wild type MEF assessed as luciferase activity at 10 to 20 uM after 24 hrs by Western blotting relative to control	2010	Bioorganic & medicinal chemistry letters, Apr-15, Volume: 20, Issue:8	Enhanced Nrf2-dependent induction of glutathione in mouse embryonic fibroblasts by isoselenocyanate analog of sulforaphane.
AID1373840	Half life in rat	2018	Bioorganic & medicinal chemistry letters, 02-15, Volume: 28, Issue:4	Therapeutic effects of isothiocyanate prodrugs on rheumatoid arthritis.
AID1579161	Antiproliferative activity against human SiHa cells assessed as inhibition of cell viability after 72 hrs by CCK-8 assay	2019	European journal of medicinal chemistry, Nov-01, Volume: 181	Novel cyclin-dependent kinase 9 (CDK9) inhibitor with suppression of cancer stemness activity against non-small-cell lung cancer.
AID1219962	Cytoprotective activity against mouse fibroblasts assessed as reduction in GSH level at 3 uM after 18 to 24 hrs relative to control	2012	Drug metabolism and disposition: the biological fate of chemicals, Apr, Volume: 40, Issue:4	Metabolism of [6]-shogaol in mice and in cancer cells.
AID476679	Induction of glutathione production in NrF2 deficient MEF at 10 to 20 uM after 24 hrs using Elmans reagent	2010	Bioorganic & medicinal chemistry letters, Apr-15, Volume: 20, Issue:8	Enhanced Nrf2-dependent induction of glutathione in mouse embryonic fibroblasts by isoselenocyanate analog of sulforaphane.
AID1579158	Antiproliferative activity against human HepG2 cells assessed as inhibition of cell viability after 72 hrs by CCK-8 assay	2019	European journal of medicinal chemistry, Nov-01, Volume: 181	Novel cyclin-dependent kinase 9 (CDK9) inhibitor with suppression of cancer stemness activity against non-small-cell lung cancer.
AID1765441	Antiinflammatory activity against mouse peritoneal macrophages assessed as inhibition of LPS-induced NO production at 10 uM measured after 24 hrs by Griess assay	2021	European journal of medicinal chemistry, Oct-15, Volume: 222	Structure-based molecular hybridization design of Keap1-Nrf2 inhibitors as novel protective agents of acute lung injury.
AID1608139	Cytoprotection activity against H2O2-induced cell death in rat HBZY-1 cells assessed as cell viability at 6 uM preincubated with compound for 2 hrs followed by H2O2 addition and measured after 24 hrs by MTT assay (Rvb = 62.1%)	2019	European journal of medicinal chemistry, Oct-15, Volume: 180	Synthesis and assessment of phenylacrylamide derivatives as potential anti-oxidant and anti-inflammatory agents.
AID1373841	Half life in human	2018	Bioorganic & medicinal chemistry letters, 02-15, Volume: 28, Issue:4	Therapeutic effects of isothiocyanate prodrugs on rheumatoid arthritis.
AID476695	Reduction of NrF2-mediated glutathione production in wild type MEF at 20 uM after 6 hrs using Elmans reagent relative to control	2010	Bioorganic & medicinal chemistry letters, Apr-15, Volume: 20, Issue:8	Enhanced Nrf2-dependent induction of glutathione in mouse embryonic fibroblasts by isoselenocyanate analog of sulforaphane.
AID1248063	Inhibition of mCherry labeled Keap1 interaction to ETGE motif from Nrf2 in human HEK293 cells at 10 uM by FRET based assay	2015	Journal of medicinal chemistry, Sep-24, Volume: 58, Issue:18	Design, Synthesis, and Evaluation of Triazole Derivatives That Induce Nrf2 Dependent Gene Products and Inhibit the Keap1-Nrf2 Protein-Protein Interaction.
AID356396	Inhibition of 7,12-dimethylbenz[a]anthracene-induced preneoplastic lesions in a mouse mammary gland culture at 1 ug/mL	2003	Journal of natural products, Sep, Volume: 66, Issue:9	Potential cncer chemopreventive flavonoids from the stems of Tephrosia toxicaria.
AID1765443	Inhibition of Keap1-Nrf2 interaction in mouse peritoneal macrophages assessed as increase in nuclear translocation of Nrf2 by measuring increase in nuclear Nrf2 level at 10 uM measured after 3 to 6 hrs by Western blot analysis	2021	European journal of medicinal chemistry, Oct-15, Volume: 222	Structure-based molecular hybridization design of Keap1-Nrf2 inhibitors as novel protective agents of acute lung injury.
AID490158	Induction of human NQO1 activity in mouse Hepa-1c1c7 cells assessed as concentration require for 2 fold induction after 48 hrs	2010	European journal of medicinal chemistry, Jul, Volume: 45, Issue:7	Functionalized aurones as inducers of NAD(P)H:quinone oxidoreductase 1 that activate AhR/XRE and Nrf2/ARE signaling pathways: synthesis, evaluation and SAR.
AID356305	Chemoprevention index, ratio of IC50 for mouse Hepa-1c1c7 cells to CD for NADPH:quinone reductase specific activity in mouse Hepa-1c1c7 cells	2003	Journal of natural products, Aug, Volume: 66, Issue:8	Isolation and characterization of miscellaneous secondary metabolites of Deprea subtriflora.
AID1579164	Antiproliferative activity against human U937 cells assessed as inhibition of cell viability after 72 hrs by CCK-8 assay	2019	European journal of medicinal chemistry, Nov-01, Volume: 181	Novel cyclin-dependent kinase 9 (CDK9) inhibitor with suppression of cancer stemness activity against non-small-cell lung cancer.
AID439590	Increase in NQO1 activity in human T67 cells assessed reduction of 2,6-dichloroindophenol per mg of cellular protein at 2.5 uM relative to control	2009	Journal of medicinal chemistry, Dec-10, Volume: 52, Issue:23	Toward a rational design of multitarget-directed antioxidants: merging memoquin and lipoic acid molecular frameworks.
AID1054578	Ratio of residual Vmax to Km for recombinant human MAO-B expressed in baculovirus infected BT1 cells assessed as residual activity using benzylamine as substrate at 20 uM preincubated for 30 mins by Amplex Red assay	2013	European journal of medicinal chemistry, , Volume: 70	Novel polyamine analogues: from substrates towards potential inhibitors of monoamine oxidases.
AID1579162	Antiproliferative activity against human Jurkat cells assessed as inhibition of cell viability after 72 hrs by CCK-8 assay	2019	European journal of medicinal chemistry, Nov-01, Volume: 181	Novel cyclin-dependent kinase 9 (CDK9) inhibitor with suppression of cancer stemness activity against non-small-cell lung cancer.
AID707728	Increase in MAPK signaling pathway gene expression in human PC3 cells at 10 uM incubated for 8 hrs by Affymetrix human exon array relative to untreated control	2012	Journal of medicinal chemistry, Nov-26, Volume: 55, Issue:22	Enhanced in vitro biological activity of synthetic 2-(2-pyridyl) ethyl isothiocyanate compared to natural 4-(methylsulfinyl) butyl isothiocyanate.
AID1396799	Antiproliferative activity against human LoVo/DX cells after 72 hrs by SRB assay	2018	Bioorganic & medicinal chemistry letters, 08-15, Volume: 28, Issue:15	Phosphorus-containing isothiocyanate-derived mercapturic acids as a useful alternative for parental isothiocyanates in experimental oncology.
AID380761	Inhibition of mouse Hepa-1c1c7 TAOc1Bprc1 mutant cells assessed as cell viability	2006	Journal of natural products, Mar, Volume: 69, Issue:3	Quinone reductase induction as a biomarker for cancer chemoprevention.
AID754017	Induction of apoptosis in human HepG2 cells assessed as early apoptotic cells at 10 uM after 48 hrs by Annexin-V-FITC/propidium iodide staining-based flow cytometric analysis (Rvb = 0.14%)	2013	European journal of medicinal chemistry, Jun, Volume: 64	Synthesis and biological evaluation of sulforaphane derivatives as potential antitumor agents.
AID214835	Antiproliferative activity against epimastigote form of Trypanosoma cruzi	2002	Journal of medicinal chemistry, Aug-29, Volume: 45, Issue:18	Design, synthesis, and biological evaluation of aryloxyethyl thiocyanate derivatives against Trypanosoma cruzi.
AID1657397	Activation of Nrf2 in human BEAS2B cells harboring wild type Keap1 assessed as increase in Nrf2 protein expression at 2.5 uM after12 hrs in presence of Keap1-siRNA by immunoblot analysis	2020	Journal of natural products, 04-24, Volume: 83, Issue:4	4β-Hydroxywithanolide E from Goldenberry (Whole Fruits of
AID476672	Cytotoxicity against human HepG2 cells assessed as cell viability at 20 uM after 6 hrs by MTS assay	2010	Bioorganic & medicinal chemistry letters, Apr-15, Volume: 20, Issue:8	Enhanced Nrf2-dependent induction of glutathione in mouse embryonic fibroblasts by isoselenocyanate analog of sulforaphane.
AID692164	Induction of p53 G245C mutant depletion in human NCI-H596 cells at 40 uM incubated for 2 hrs by immunoblot analysis	2011	Journal of medicinal chemistry, Feb-10, Volume: 54, Issue:3	Selective depletion of mutant p53 by cancer chemopreventive isothiocyanates and their structure-activity relationships.
AID1579224	Inhibition of tumorsphere formation in human H1299 cells assessed as decrease in number of spheres at 1 uM after 2 weeks by microscopic analysis	2019	European journal of medicinal chemistry, Nov-01, Volume: 181	Novel cyclin-dependent kinase 9 (CDK9) inhibitor with suppression of cancer stemness activity against non-small-cell lung cancer.
AID1243385	Induction of NQO1 in mouse Hepa-1c1c7 cells assessed as drug concentration required to double induction by quinone reductase assay	2015	Bioorganic & medicinal chemistry letters, Sep-15, Volume: 25, Issue:18	Identification of dialkyl diacetylene diols with potent cancer chemopreventive activity.
AID476678	Induction of nuclear NrF2-mediated GCLc expression in wild type MEF at 20 uM after 24 hrs by Western blotting relative to control	2010	Bioorganic & medicinal chemistry letters, Apr-15, Volume: 20, Issue:8	Enhanced Nrf2-dependent induction of glutathione in mouse embryonic fibroblasts by isoselenocyanate analog of sulforaphane.
AID1400544	Activation of Nrf2 in human MDA-MB-231 cells assessed as upregulation of Nrf2 protein expression at 2 uM after 16 hrs by immunoblot analysis	2018	Bioorganic & medicinal chemistry, 10-01, Volume: 26, Issue:18	Discovery of natural flavonoids as activators of Nrf2-mediated defense system: Structure-activity relationship and inhibition of intracellular oxidative insults.
AID1400545	Activation of Nrf2 in human MDA-MB-231 cells assessed as upregulation of NQO1 protein expression at 2 uM after 16 hrs by immunoblot analysis	2018	Bioorganic & medicinal chemistry, 10-01, Volume: 26, Issue:18	Discovery of natural flavonoids as activators of Nrf2-mediated defense system: Structure-activity relationship and inhibition of intracellular oxidative insults.
AID1248055	Increase of Nrf2 protein level in mouse Hepa1c1c7 cells at 10 uM after 24 hrs by Western blot analysis	2015	Journal of medicinal chemistry, Sep-24, Volume: 58, Issue:18	Design, Synthesis, and Evaluation of Triazole Derivatives That Induce Nrf2 Dependent Gene Products and Inhibit the Keap1-Nrf2 Protein-Protein Interaction.
AID1579154	Antiproliferative activity against human HCC827 cells assessed as inhibition of cell viability after 72 hrs by CCK-8 assay	2019	European journal of medicinal chemistry, Nov-01, Volume: 181	Novel cyclin-dependent kinase 9 (CDK9) inhibitor with suppression of cancer stemness activity against non-small-cell lung cancer.
AID1579163	Antiproliferative activity against human CCRF-CEM cells assessed as inhibition of cell viability after 72 hrs by CCK-8 assay	2019	European journal of medicinal chemistry, Nov-01, Volume: 181	Novel cyclin-dependent kinase 9 (CDK9) inhibitor with suppression of cancer stemness activity against non-small-cell lung cancer.
AID1474542	Cytotoxicity against human LoVo/DX cells after 72 hrs by sulforhodamine B assay	2017	European journal of medicinal chemistry, May-26, Volume: 132	Novel phosphonate analogs of sulforaphane: Synthesis, in vitro and in vivo anticancer activity.
AID1418251	Antiproliferative activity against human HCT116 cells after 72 hrs by CCK8 assay	2018	European journal of medicinal chemistry, Sep-05, Volume: 157	Design, synthesis and biological evaluation of novel carbamodithioates as anti-proliferative agents against human cancer cells.
AID1579178	Induction of apoptosis in human A549 cells assessed as necrotic cells at 1 uM after 48 hrs by AnnexinV-FITC/PI staining-based flow cytometric analysis (Rvb = 0.664%)	2019	European journal of medicinal chemistry, Nov-01, Volume: 181	Novel cyclin-dependent kinase 9 (CDK9) inhibitor with suppression of cancer stemness activity against non-small-cell lung cancer.
AID659238	Increase in intracellular GSH level in human MCF7 cells expressing antioxidant response element at 10 uM after 24 hrs by HPLC analysis	2012	Journal of medicinal chemistry, Feb-09, Volume: 55, Issue:3	A synthetic chalcone as a potent inducer of glutathione biosynthesis.
AID1128079	Inhibition of Keap1-Nrf2 interaction in human HepG2-ARE-C8 cells assessed as activation of Nrf2-ARE luciferase activity at 5 uM after 12 hrs relative to control	2014	Journal of medicinal chemistry, Mar-27, Volume: 57, Issue:6	Discovery of potent Keap1-Nrf2 protein-protein interaction inhibitor based on molecular binding determinants analysis.
AID436121	Cell cycle arrest in human LTEP-A2 cells assessed as accumulation at S phase at 50 uM after 24 hrs by flow cytometry	2008	Journal of natural products, Nov, Volume: 71, Issue:11	Sulforaphane induces cell-cycle arrest and apoptosis in cultured human lung adenocarcinoma LTEP-A2 cells and retards growth of LTEP-A2 xenografts in vivo.
AID436124	Cell cycle arrest in human LTEP-A2 cells assessed as accumulation at G2/M phase at 50 uM after 3 hrs by flow cytometry	2008	Journal of natural products, Nov, Volume: 71, Issue:11	Sulforaphane induces cell-cycle arrest and apoptosis in cultured human lung adenocarcinoma LTEP-A2 cells and retards growth of LTEP-A2 xenografts in vivo.
AID294479	Induction of quinone reductase activity in mouse mutant Hepa 1c1c7c1 cells assessed as concentration required to double the enzyme activity	2007	European journal of medicinal chemistry, Jun, Volume: 42, Issue:6	Quinone reductase induction activity of methoxylated analogues of resveratrol.
AID436119	Cell cycle arrest in human LTEP-A2 cells assessed as accumulation at G0/G1 phase at 50 uM after 72 hrs by flow cytometry	2008	Journal of natural products, Nov, Volume: 71, Issue:11	Sulforaphane induces cell-cycle arrest and apoptosis in cultured human lung adenocarcinoma LTEP-A2 cells and retards growth of LTEP-A2 xenografts in vivo.
AID1248060	Activation of Nrf2 in mouse Hepa1c1c7 cells assessed as increase of HO-1 expression at 10 uM after 6 hrs by Western blot analysis	2015	Journal of medicinal chemistry, Sep-24, Volume: 58, Issue:18	Design, Synthesis, and Evaluation of Triazole Derivatives That Induce Nrf2 Dependent Gene Products and Inhibit the Keap1-Nrf2 Protein-Protein Interaction.
AID679059	TP_TRANSPORTER: Western in vitro, primary rat hepatocyte	2001	Biochemical and biophysical research communications, Mar-23, Volume: 282, Issue:1	Reactive oxygen species-related induction of multidrug resistance-associated protein 2 expression in primary hepatocytes exposed to sulforaphane.
AID1418270	Cell cycle arrest in human SMMC7721 cells assessed as accumulation at G2/M phase at 8 uM after 72 hrs by RNase/propidium iodide staining-based flow cytometric analysis (Rvb = 24.78%)	2018	European journal of medicinal chemistry, Sep-05, Volume: 157	Design, synthesis and biological evaluation of novel carbamodithioates as anti-proliferative agents against human cancer cells.
AID163303	In vitro potency to induce quinone reductase activity in murine hepatoma cells was determined	1994	Journal of medicinal chemistry, Jan-07, Volume: 37, Issue:1	Design and synthesis of bifunctional isothiocyanate analogs of sulforaphane: correlation between structure and potency as inducers of anticarcinogenic detoxication enzymes.
AID436149	Antitumor activity against human PANC1 cells xenografted in severe combined immunodeficient mouse assessed as reduction in mean tumor volume at 66 mg/kg/day, po administered for 3 weeks by Western blot assay relative to control	2008	Journal of natural products, Nov, Volume: 71, Issue:11	Sulforaphane induces cell-cycle arrest and apoptosis in cultured human lung adenocarcinoma LTEP-A2 cells and retards growth of LTEP-A2 xenografts in vivo.
AID481444	Octanol-water partition coefficient, log P of the compound	2010	Journal of medicinal chemistry, May-13, Volume: 53, Issue:9	How well can the Caco-2/Madin-Darby canine kidney models predict effective human jejunal permeability?
AID707729	Increase in toll-like receptor signaling pathway gene expression in human PC3 cells at 10 uM incubated for 8 hrs by Affymetrix human exon array relative to untreated control	2012	Journal of medicinal chemistry, Nov-26, Volume: 55, Issue:22	Enhanced in vitro biological activity of synthetic 2-(2-pyridyl) ethyl isothiocyanate compared to natural 4-(methylsulfinyl) butyl isothiocyanate.
AID692256	Induction of p53 R280K mutant depletion in human MDA-MB-231 cells at 10 uM by immunoblot analysis	2011	Journal of medicinal chemistry, Feb-10, Volume: 54, Issue:3	Selective depletion of mutant p53 by cancer chemopreventive isothiocyanates and their structure-activity relationships.
AID1577834	Glutathione reactivity in HEPES buffer assessed as GSH-adduct formation at 500 uM measured after 10 to 30 mins by UHPLC-MS analysis	2019	Journal of medicinal chemistry, 09-12, Volume: 62, Issue:17	A Comparative Assessment Study of Known Small-Molecule Keap1-Nrf2 Protein-Protein Interaction Inhibitors: Chemical Synthesis, Binding Properties, and Cellular Activity.
AID361395	Cytotoxicity against mouse Hepa-1c1c7 cells	2002	Journal of natural products, Nov, Volume: 65, Issue:11	Activity-guided isolation of constituents of Renealmia nicolaioides with the potential to induce the phase II enzyme quinone reductase.
AID436111	Cell cycle arrest in human LTEP-A2 cells assessed as accumulation at S phase at 6.25 uM after 72 hrs by flow cytometry	2008	Journal of natural products, Nov, Volume: 71, Issue:11	Sulforaphane induces cell-cycle arrest and apoptosis in cultured human lung adenocarcinoma LTEP-A2 cells and retards growth of LTEP-A2 xenografts in vivo.
AID1657373	Activation of Nrf2 in human MDA-MB-231 cells assessed as increase in Nrf2 protein level at 2 uM incubated for 16 hrs by immunoblot analysis	2020	Journal of natural products, 04-24, Volume: 83, Issue:4	4β-Hydroxywithanolide E from Goldenberry (Whole Fruits of
AID1396798	Antiproliferative activity against human LoVo cells after 72 hrs by SRB assay	2018	Bioorganic & medicinal chemistry letters, 08-15, Volume: 28, Issue:15	Phosphorus-containing isothiocyanate-derived mercapturic acids as a useful alternative for parental isothiocyanates in experimental oncology.
AID1579223	Inhibition of tumorsphere formation in human A549 cells assessed as decrease in number of spheres at 1 uM after 2 weeks by microscopic analysis	2019	European journal of medicinal chemistry, Nov-01, Volume: 181	Novel cyclin-dependent kinase 9 (CDK9) inhibitor with suppression of cancer stemness activity against non-small-cell lung cancer.
AID214838	Inhibitory activity towards Trypanosoma cruzi	2002	Journal of medicinal chemistry, Aug-29, Volume: 45, Issue:18	Design, synthesis, and biological evaluation of aryloxyethyl thiocyanate derivatives against Trypanosoma cruzi.
AID436107	Cell cycle arrest in human LTEP-A2 cells assessed as accumulation at G0/G1 phase at 6.25 uM after 72 hrs by flow cytometry	2008	Journal of natural products, Nov, Volume: 71, Issue:11	Sulforaphane induces cell-cycle arrest and apoptosis in cultured human lung adenocarcinoma LTEP-A2 cells and retards growth of LTEP-A2 xenografts in vivo.
AID490159	Induction of human NQO1 activity in mutant mouse BPrc1 cells assessed as concentration require for 2 fold induction after 48 hrs	2010	European journal of medicinal chemistry, Jul, Volume: 45, Issue:7	Functionalized aurones as inducers of NAD(P)H:quinone oxidoreductase 1 that activate AhR/XRE and Nrf2/ARE signaling pathways: synthesis, evaluation and SAR.
AID1579177	Induction of apoptosis in human A549 cells assessed as late apoptotic cells at 1 uM after 48 hrs by AnnexinV-FITC/PI staining-based flow cytometric analysis (Rvb = 7.66%)	2019	European journal of medicinal chemistry, Nov-01, Volume: 181	Novel cyclin-dependent kinase 9 (CDK9) inhibitor with suppression of cancer stemness activity against non-small-cell lung cancer.
AID707919	Increase in cytokine-cytokine receptor interaction related gene expression in human PNT1A cells at 10 uM incubated for 8 hrs by Affymetrix human exon array relative to untreated control	2012	Journal of medicinal chemistry, Nov-26, Volume: 55, Issue:22	Enhanced in vitro biological activity of synthetic 2-(2-pyridyl) ethyl isothiocyanate compared to natural 4-(methylsulfinyl) butyl isothiocyanate.
AID436143	Antiproliferative activity against human lymphoblastoid cells using annexin-V FITC and PI staining by flow cytometry	2008	Journal of natural products, Nov, Volume: 71, Issue:11	Sulforaphane induces cell-cycle arrest and apoptosis in cultured human lung adenocarcinoma LTEP-A2 cells and retards growth of LTEP-A2 xenografts in vivo.
AID436133	Induction of apoptosis in human LTEP-A2 cells assessed as sub-G0/G1 DNA content at 50 uM after 24 hrs by propidium iodide based flow cytometry	2008	Journal of natural products, Nov, Volume: 71, Issue:11	Sulforaphane induces cell-cycle arrest and apoptosis in cultured human lung adenocarcinoma LTEP-A2 cells and retards growth of LTEP-A2 xenografts in vivo.
AID334283	Growth inhibition of mouse Hepa-1c1c7 cells by crystal violet staining	2002	Journal of natural products, May, Volume: 65, Issue:5	Induction of quinone reductase by withanolides.
AID1657402	Activation of Nrf2 in human BEAS2B cells harboring Keap1-C288S mutant assessed as increase in Nrf2 protein expression at 5 uM after12 hrs in presence of Keap1-siRNA by immunoblot analysis	2020	Journal of natural products, 04-24, Volume: 83, Issue:4	4β-Hydroxywithanolide E from Goldenberry (Whole Fruits of
AID355764	Chemoprevention index, ratio of IC50 for mouse Hepa-1c1c7 cells to drug level required to double quinone reductase activity in mouse Hepa-1c1c7 cells	2003	Journal of natural products, May, Volume: 66, Issue:5	Potential cancer chemopreventive constituents of the seeds of Dipteryx odorata (tonka bean).
AID356415	Inhibition of mouse Hepa-1c1c7 cells assessed as cell viability	2003	Journal of natural products, Sep, Volume: 66, Issue:9	Constituents of the stem bark of Pongamia pinnata with the potential to induce quinone reductase.
AID355766	Inhibition of 7,12-dimethylbenz[a]anthracene-induced periplastic lesions in mouse mammary organ culture model at 1 ug/ml	2003	Journal of natural products, May, Volume: 66, Issue:5	Potential cancer chemopreventive constituents of the seeds of Dipteryx odorata (tonka bean).
AID476684	Induction of NrF2 in human HepG2 cells at 10 uM after 6 hrs by ARE-luciferase reporter gene assay	2010	Bioorganic & medicinal chemistry letters, Apr-15, Volume: 20, Issue:8	Enhanced Nrf2-dependent induction of glutathione in mouse embryonic fibroblasts by isoselenocyanate analog of sulforaphane.
AID1227828	Renoprotective activity against cisplatin-induced cytotoxicity in pig LLC-PK1 cells assessed as cell survival at 10 uM after 24 hrs by WST-1 assay in presence of 25 uM cisplatin (Rvb = 60%)	2015	Bioorganic & medicinal chemistry letters, Jan-01, Volume: 25, Issue:1	The synthesis of sulforaphane analogues and their protection effect against cisplatin induced cytotoxicity in kidney cells.
AID754012	Activation of NRF2 in human HepG2 cells at 20 uM by spectrophotometric analysis	2013	European journal of medicinal chemistry, Jun, Volume: 64	Synthesis and biological evaluation of sulforaphane derivatives as potential antitumor agents.
AID1579187	Induction of apoptosis in human H1299 cells assessed as viable cells at 1 uM after 48 hrs by AnnexinV-FITC/PI staining-based flow cytometric analysis (Rvb = 97.1%)	2019	European journal of medicinal chemistry, Nov-01, Volume: 181	Novel cyclin-dependent kinase 9 (CDK9) inhibitor with suppression of cancer stemness activity against non-small-cell lung cancer.
AID1474541	Cytotoxicity against human LoVo cells after 72 hrs by sulforhodamine B assay	2017	European journal of medicinal chemistry, May-26, Volume: 132	Novel phosphonate analogs of sulforaphane: Synthesis, in vitro and in vivo anticancer activity.
AID417743	Induction of NQO1 activity in mouse Hepa-1c1c7 cells assessed as induction ratio at 1 uM after 48 hrs by MTT assay relative to control	2009	Bioorganic & medicinal chemistry, Mar-01, Volume: 17, Issue:5	Functionalized 3-benzylidene-indolin-2-ones: inducers of NAD(P)H-quinone oxidoreductase 1 (NQO1) with antiproliferative activity.
AID1418269	Cell cycle arrest in human SMMC7721 cells assessed as accumulation at S phase at 8 uM after 72 hrs by RNase/propidium iodide staining-based flow cytometric analysis (Rvb = 7.96%)	2018	European journal of medicinal chemistry, Sep-05, Volume: 157	Design, synthesis and biological evaluation of novel carbamodithioates as anti-proliferative agents against human cancer cells.
AID640743	Induction of apoptosis in human Jurkat T cells assessed as increase in necrotic cells at 30 uM after 24 hrs by 7-AA staining-based flow cytometric analysis	2012	European journal of medicinal chemistry, Feb, Volume: 48	Design, synthesis and biological evaluation of new naphtalene diimides bearing isothiocyanate functionality.
AID1765440	Antiinflammatory activity against mouse peritoneal macrophages assessed as inhibition of LPS-stimulated ROS production at 10 uM incubated for 6 hrs by DCFH-DA staining based fluorescence analysis	2021	European journal of medicinal chemistry, Oct-15, Volume: 222	Structure-based molecular hybridization design of Keap1-Nrf2 inhibitors as novel protective agents of acute lung injury.
AID1248061	Activation of Nrf2 in mouse Hepa1c1c7 cells assessed as increase of NQO1 expression at 10 uM measured before 24 hrs by Western blot analysis	2015	Journal of medicinal chemistry, Sep-24, Volume: 58, Issue:18	Design, Synthesis, and Evaluation of Triazole Derivatives That Induce Nrf2 Dependent Gene Products and Inhibit the Keap1-Nrf2 Protein-Protein Interaction.
AID1519184	Activation of NRF2 in human BV2 cells assessed as upregulation of HO1 at 5 uM by ELISA relative to control	2020	European journal of medicinal chemistry, Jan-01, Volume: 185	A novel chalcone derivative as Nrf2 activator attenuates learning and memory impairment in a scopolamine-induced mouse model.
AID380750	Inhibition of mouse Hepa-1c1c7 cells assessed as cell viability	2006	Journal of natural products, Mar, Volume: 69, Issue:3	Quinone reductase induction as a biomarker for cancer chemoprevention.
AID1418256	Inhibition of colony formation in human SMMC7721 cells at 2 to 8 uM after 7 days by crystal violet staining-based assay	2018	European journal of medicinal chemistry, Sep-05, Volume: 157	Design, synthesis and biological evaluation of novel carbamodithioates as anti-proliferative agents against human cancer cells.
AID1474566	Induction of apoptosis in human LoVo cells assessed as necrotic cells at 15 uM after 24 hrs by APC-Annexin-V/propidium iodide staining based flow cytometric method (Rvb = 10%)	2017	European journal of medicinal chemistry, May-26, Volume: 132	Novel phosphonate analogs of sulforaphane: Synthesis, in vitro and in vivo anticancer activity.
AID1657364	Activation of Nrf2 in mouse Hepa1c1c7 cells assessed as increase in quinone reductase activity at 2 uM incubated for 24 hrs by MTT based assay	2020	Journal of natural products, 04-24, Volume: 83, Issue:4	4β-Hydroxywithanolide E from Goldenberry (Whole Fruits of
AID1577833	Binding affinity to recombinant human KEAP1 Kelch domain (321 to 609 residues) expressed in Escherichia coli BL21 (DE3) assessed as compound-adduct formation at >=20 uM measured after 1 to 3 hrs by LC-MS analysis	2019	Journal of medicinal chemistry, 09-12, Volume: 62, Issue:17	A Comparative Assessment Study of Known Small-Molecule Keap1-Nrf2 Protein-Protein Interaction Inhibitors: Chemical Synthesis, Binding Properties, and Cellular Activity.
AID1198788	Inhibition of macrophage migration inhibitory factor tautomerase activity in human Jurkat T cells using L-dopachrome methyl ester as substrate incubated for 30 mins prior to substrate addition measured for 2 mins by spectrophotometric analysis	2015	European journal of medicinal chemistry, Mar-26, Volume: 93	Multiple binding modes of isothiocyanates that inhibit macrophage migration inhibitory factor.
AID380759	Chemoprevention index, ratio of IC50 for mouse Hepa-1c1c7 Bprc1 mutant cells to drug level required to double specific NADPH:quinone reductase activity in mouse Hepa-1c1c7 Bprc1 mutant cells	2006	Journal of natural products, Mar, Volume: 69, Issue:3	Quinone reductase induction as a biomarker for cancer chemoprevention.
AID1826665	Inhibition of human recombinant MAO-B using tyramine as substrate by fluorescence assay	2022	Journal of medicinal chemistry, 03-24, Volume: 65, Issue:6	Resveratrol-Based MTDLs to Stimulate Defensive and Regenerative Pathways and Block Early Events in Neurodegenerative Cascades.
AID1510919	Activation of ED-tagged Nrf2 in human U2OS cells co-expressing Keap1 assessed as induction of NRF2 translocation to nucleus after 6 hrs by beta-galactosidase based chemiluminescent assay	2019	ACS medicinal chemistry letters, Jul-11, Volume: 10, Issue:7	Antioxidant, Anti-inflammatory, and Neuroprotective Effects of Novel Vinyl Sulfonate Compounds as Nrf2 Activator.
AID1474554	Cell cycle arrest in human LoVo cells assessed as accumulation at G2/M phase at >15 uM after 24 hrs by propidium iodide staining based flow cytometric method	2017	European journal of medicinal chemistry, May-26, Volume: 132	Novel phosphonate analogs of sulforaphane: Synthesis, in vitro and in vivo anticancer activity.
AID707934	Binding affinity to insulin A chain N-terminal pentapeptide assessed as compound-insulin adduct formation by LC-MS method	2012	Journal of medicinal chemistry, Nov-26, Volume: 55, Issue:22	Enhanced in vitro biological activity of synthetic 2-(2-pyridyl) ethyl isothiocyanate compared to natural 4-(methylsulfinyl) butyl isothiocyanate.
AID1765438	Inhibition of Keap1-Nrf2 (unknown origin) interaction measured after 60 mins by Fluorescence polarization assay	2021	European journal of medicinal chemistry, Oct-15, Volume: 222	Structure-based molecular hybridization design of Keap1-Nrf2 inhibitors as novel protective agents of acute lung injury.
AID707926	Inhibition of cell proliferation of human PC3 cells at 25 uM incubated for 24 hrs by BrdU incorporation assay	2012	Journal of medicinal chemistry, Nov-26, Volume: 55, Issue:22	Enhanced in vitro biological activity of synthetic 2-(2-pyridyl) ethyl isothiocyanate compared to natural 4-(methylsulfinyl) butyl isothiocyanate.
AID1128076	Inhibition of Keap1-Nrf2 interaction in human HepG2-ARE-C8 cells assessed as activation of Nrf2-ARE luciferase activity at 0.1 uM after 12 hrs relative to control	2014	Journal of medicinal chemistry, Mar-27, Volume: 57, Issue:6	Discovery of potent Keap1-Nrf2 protein-protein interaction inhibitor based on molecular binding determinants analysis.
AID436112	Cell cycle arrest in human LTEP-A2 cells assessed as accumulation at G2/M phase at 6.25 uM after 3 hrs by flow cytometry	2008	Journal of natural products, Nov, Volume: 71, Issue:11	Sulforaphane induces cell-cycle arrest and apoptosis in cultured human lung adenocarcinoma LTEP-A2 cells and retards growth of LTEP-A2 xenografts in vivo.
AID754013	Induction of apoptosis in human HepG2 cells assessed as late apoptotic cells at 20 uM after 48 hrs by Annexin-V-FITC/propidium iodide staining-based flow cytometric analysis (Rvb = 0.29%)	2013	European journal of medicinal chemistry, Jun, Volume: 64	Synthesis and biological evaluation of sulforaphane derivatives as potential antitumor agents.
AID1519148	Activation of NRF2 in human U2OS cells co-expressing Keap1 (unknown origin) assessed as induction of NRF2 translocation to nucleus incubated for 6 hrs by beta-galactosidase based chemiluminescent assay	2020	European journal of medicinal chemistry, Jan-01, Volume: 185	A novel chalcone derivative as Nrf2 activator attenuates learning and memory impairment in a scopolamine-induced mouse model.
AID1418249	Antiproliferative activity against human A549 cells after 72 hrs by CCK8 assay	2018	European journal of medicinal chemistry, Sep-05, Volume: 157	Design, synthesis and biological evaluation of novel carbamodithioates as anti-proliferative agents against human cancer cells.
AID1579152	Antiproliferative activity against human H1299 cells assessed as inhibition of cell viability after 72 hrs by CCK-8 assay	2019	European journal of medicinal chemistry, Nov-01, Volume: 181	Novel cyclin-dependent kinase 9 (CDK9) inhibitor with suppression of cancer stemness activity against non-small-cell lung cancer.
AID754028	Cytotoxicity against human HepG2 cells after 72 hrs by MTT assay	2013	European journal of medicinal chemistry, Jun, Volume: 64	Synthesis and biological evaluation of sulforaphane derivatives as potential antitumor agents.
AID1054580	Activity at recombinant human MAO-B expressed in baculovirus infected BT1 cells assessed as residual activity using benzylamine as substrate at 20 uM preincubated for 30 mins by Amplex Red assay relative to control	2013	European journal of medicinal chemistry, , Volume: 70	Novel polyamine analogues: from substrates towards potential inhibitors of monoamine oxidases.
AID1579190	Induction of apoptosis in human H1299 cells assessed as necrotic cells at 1 uM after 48 hrs by AnnexinV-FITC/PI staining-based flow cytometric analysis (Rvb = 0.9%)	2019	European journal of medicinal chemistry, Nov-01, Volume: 181	Novel cyclin-dependent kinase 9 (CDK9) inhibitor with suppression of cancer stemness activity against non-small-cell lung cancer.
AID480521	Induction of NQO1 activity in human M07e cells at 5 uM after 24 to 48 hrs by fluorescence plate reader	2010	Bioorganic & medicinal chemistry, May-01, Volume: 18, Issue:9	Antitumor activity and COMPARE analysis of bis-indole derivatives.
AID1826672	Displacement of 2-[125l]-lodomelatonin from QR2 in hamster brain homogenate by radioligand binding assay	2022	Journal of medicinal chemistry, 03-24, Volume: 65, Issue:6	Resveratrol-Based MTDLs to Stimulate Defensive and Regenerative Pathways and Block Early Events in Neurodegenerative Cascades.
AID476671	Cytotoxicity against human HepG2 cells assessed as cell viability at 10 uM after 6 hrs by MTS assay	2010	Bioorganic & medicinal chemistry letters, Apr-15, Volume: 20, Issue:8	Enhanced Nrf2-dependent induction of glutathione in mouse embryonic fibroblasts by isoselenocyanate analog of sulforaphane.
AID355762	Growth inhibition of mouse Hepa-1c1c7 cells	2003	Journal of natural products, May, Volume: 66, Issue:5	Potential cancer chemopreventive constituents of the seeds of Dipteryx odorata (tonka bean).
AID1198787	Inhibition of human recombinant macrophage migration inhibitory factor tautomerase activity expressed in Escherichia coli DH5alpha using L-dopachrome methyl ester as substrate incubated for 5 mins prior to substrate addition measured for 2 mins by spectro	2015	European journal of medicinal chemistry, Mar-26, Volume: 93	Multiple binding modes of isothiocyanates that inhibit macrophage migration inhibitory factor.
AID1536345	Binding affinity to FLAG/His-tagged Keap1 (unknown origin)/biotinylated full-length FLAG/His/Tev/Avi-tagged Cul3 (unknown origin) expressed in baculovirus infected Sf9 insect cells measured after 1 hr by TR-FRET assay	2019	Bioorganic & medicinal chemistry, 02-15, Volume: 27, Issue:4	Discovery of a crystalline sulforaphane analog with good solid-state stability and engagement of the Nrf2 pathway in vitro and in vivo.
AID1536358	Inhibition of Bach1-Mafk interaction (unknown origin) by luciferase reporter gene based enzyme fragment complementation assay	2019	Bioorganic & medicinal chemistry, 02-15, Volume: 27, Issue:4	Discovery of a crystalline sulforaphane analog with good solid-state stability and engagement of the Nrf2 pathway in vitro and in vivo.
AID481442	Transcellular permeability at pH 6.5 calculated from in vitro P app values in Caco-2 and/or MDCK cells	2010	Journal of medicinal chemistry, May-13, Volume: 53, Issue:9	How well can the Caco-2/Madin-Darby canine kidney models predict effective human jejunal permeability?
AID1418263	Induction of apoptosis in human SMMC7721 cells assessed as early apoptotic cells at 8 uM after 72 hrs by Alexa Fluor 488 Annexin/propidium iodide staining-based flow cytometric analysis (Rvb = 0.70%)	2018	European journal of medicinal chemistry, Sep-05, Volume: 157	Design, synthesis and biological evaluation of novel carbamodithioates as anti-proliferative agents against human cancer cells.
AID1414080	Antagonist activity at Pseudomonas aeruginosa PAO1 GFP-fused RhlR expressed in Escherichia coli DH5alpha co-expressing rhlA promoter assessed as inhibition of L-arabinose-induced C4-HSL production at 2.27 mM after 5 hrs relative to control	2018	Journal of medicinal chemistry, 12-13, Volume: 61, Issue:23	Pseudomonas aeruginosa Quorum Sensing Systems as Drug Discovery Targets: Current Position and Future Perspectives.
AID436144	Antiproliferative activity against human DU145 cells assessed as viable cells after 24 hrs	2008	Journal of natural products, Nov, Volume: 71, Issue:11	Sulforaphane induces cell-cycle arrest and apoptosis in cultured human lung adenocarcinoma LTEP-A2 cells and retards growth of LTEP-A2 xenografts in vivo.
AID436139	Antitumor activity against human LTEP-A2 cells xenografted in athymic mouse assessed as reduction in wet tumor weight at 100 mg/kg, ip administered 3 times per week measured after 9 days relative to control	2008	Journal of natural products, Nov, Volume: 71, Issue:11	Sulforaphane induces cell-cycle arrest and apoptosis in cultured human lung adenocarcinoma LTEP-A2 cells and retards growth of LTEP-A2 xenografts in vivo.
AID1418262	Induction of apoptosis in human SMMC7721 cells assessed as late apoptotic cells at 8 uM after 72 hrs by Alexa Fluor 488 Annexin/propidium iodide staining-based flow cytometric analysis (Rvb = 0.62%)	2018	European journal of medicinal chemistry, Sep-05, Volume: 157	Design, synthesis and biological evaluation of novel carbamodithioates as anti-proliferative agents against human cancer cells.
AID1579155	Antiproliferative activity against human PC9 cells assessed as inhibition of cell viability after 72 hrs by CCK-8 assay	2019	European journal of medicinal chemistry, Nov-01, Volume: 181	Novel cyclin-dependent kinase 9 (CDK9) inhibitor with suppression of cancer stemness activity against non-small-cell lung cancer.
AID1579188	Induction of apoptosis in human H1299 cells assessed as early apoptotic cells at 1 uM after 48 hrs by AnnexinV-FITC/PI staining-based flow cytometric analysis (Rvb = 0.248%)	2019	European journal of medicinal chemistry, Nov-01, Volume: 181	Novel cyclin-dependent kinase 9 (CDK9) inhibitor with suppression of cancer stemness activity against non-small-cell lung cancer.
AID436130	Induction of apoptosis in human LTEP-A2 cells assessed as sub-G0/G1 DNA content at 6.25 uM after 48 hrs by propidium iodide based flow cytometry	2008	Journal of natural products, Nov, Volume: 71, Issue:11	Sulforaphane induces cell-cycle arrest and apoptosis in cultured human lung adenocarcinoma LTEP-A2 cells and retards growth of LTEP-A2 xenografts in vivo.
AID754025	Cytotoxicity against human HCT116 cells after 72 hrs by MTT assay	2013	European journal of medicinal chemistry, Jun, Volume: 64	Synthesis and biological evaluation of sulforaphane derivatives as potential antitumor agents.
AID692255	Induction of p53 G245C mutant depletion in human NCI-H596 cells at 20 uM by immunoblot analysis	2011	Journal of medicinal chemistry, Feb-10, Volume: 54, Issue:3	Selective depletion of mutant p53 by cancer chemopreventive isothiocyanates and their structure-activity relationships.
AID1418265	Cell cycle arrest in human SMMC7721 cells assessed as accumulation at G0/G1 phase at 4 uM after 72 hrs by RNase/propidium iodide staining-based flow cytometric analysis (Rvb = 67.26%)	2018	European journal of medicinal chemistry, Sep-05, Volume: 157	Design, synthesis and biological evaluation of novel carbamodithioates as anti-proliferative agents against human cancer cells.
AID1248066	Therapeutic index, ratio of GI50 for mouse Hepa1c1c7 cells to CD for activation of Nrf2 in mouse Hepa1c1c7 cells assessed as concentration required to 2 fold induction of NQO1 production	2015	Journal of medicinal chemistry, Sep-24, Volume: 58, Issue:18	Design, Synthesis, and Evaluation of Triazole Derivatives That Induce Nrf2 Dependent Gene Products and Inhibit the Keap1-Nrf2 Protein-Protein Interaction.
AID361396	Chemopreventive index, ratio of IC50 for mouse Hepa-1c1c7 cells to drug level required to double specific NADPH:quinone reductase activity in mouse Hepa-1c1c7 cells	2002	Journal of natural products, Nov, Volume: 65, Issue:11	Activity-guided isolation of constituents of Renealmia nicolaioides with the potential to induce the phase II enzyme quinone reductase.
AID606614	Cytotoxicity against human BEAS2B cells assessed as cell viability after 24 hrs by MTT assay	2011	Journal of medicinal chemistry, Jun-23, Volume: 54, Issue:12	Novel chalcone derivatives as potent Nrf2 activators in mice and human lung epithelial cells.
AID481446	Effective permeability across human jejunum	2010	Journal of medicinal chemistry, May-13, Volume: 53, Issue:9	How well can the Caco-2/Madin-Darby canine kidney models predict effective human jejunal permeability?
AID1826673	Permeability of compound in PBS buffer at pH 7.4 by PAMPA-BBB assay	2022	Journal of medicinal chemistry, 03-24, Volume: 65, Issue:6	Resveratrol-Based MTDLs to Stimulate Defensive and Regenerative Pathways and Block Early Events in Neurodegenerative Cascades.
AID1536348	Binding affinity to wild-type human N-terminal His6-tagged Keap1 (35 to 178 residues) expressed in baculovirus infected Sf9 insect cells assessed as cysteine-compound adduct formation at 15-fold molar excess measured after 1 hr by RP-LC/MS/MS analysis	2019	Bioorganic & medicinal chemistry, 02-15, Volume: 27, Issue:4	Discovery of a crystalline sulforaphane analog with good solid-state stability and engagement of the Nrf2 pathway in vitro and in vivo.
AID480524	Induction of NQO1 activity in HUVEC at 5 uM after 24 to 48 hrs by fluorescence plate reader	2010	Bioorganic & medicinal chemistry, May-01, Volume: 18, Issue:9	Antitumor activity and COMPARE analysis of bis-indole derivatives.
AID707933	Binding affinity to insulin B chain N-terminal pentapeptide assessed as compound-insulin adduct formation by LC-MS method	2012	Journal of medicinal chemistry, Nov-26, Volume: 55, Issue:22	Enhanced in vitro biological activity of synthetic 2-(2-pyridyl) ethyl isothiocyanate compared to natural 4-(methylsulfinyl) butyl isothiocyanate.
AID754022	Cell cycle arrest in human HepG2 cells assessed as accumulation at S phase after 48 hrs by DAPI staining-based flow cytometric analysis	2013	European journal of medicinal chemistry, Jun, Volume: 64	Synthesis and biological evaluation of sulforaphane derivatives as potential antitumor agents.
AID436128	Induction of apoptosis in human LTEP-A2 cells assessed as sub-G0/G1 DNA content at 6.25 uM after 3 hrs by propidium iodide based flow cytometry	2008	Journal of natural products, Nov, Volume: 71, Issue:11	Sulforaphane induces cell-cycle arrest and apoptosis in cultured human lung adenocarcinoma LTEP-A2 cells and retards growth of LTEP-A2 xenografts in vivo.
AID1794808	Fluorescence-based screening to identify small molecule inhibitors of Plasmodium falciparum apicoplast DNA polymerase (Pf-apPOL).	2014	Journal of biomolecular screening, Jul, Volume: 19, Issue:6	A High-Throughput Assay to Identify Inhibitors of the Apicoplast DNA Polymerase from Plasmodium falciparum.
AID1794808	Fluorescence-based screening to identify small molecule inhibitors of Plasmodium falciparum apicoplast DNA polymerase (Pf-apPOL).
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	20 (1.16)	18.2507
2000's	304 (17.68)	29.6817
2010's	1016 (59.10)	24.3611
2020's	379 (22.05)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	65 (3.71%)	5.53%
Reviews	152 (8.67%)	6.00%
Case Studies	2 (0.11%)	4.05%
Observational	0 (0.00%)	0.25%
Other	1,535 (87.51%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Clinical Trials (53)

Trial Overview

Trial	Phase	Enrollment	Study Type	Start Date	Status
Open-Label Trial of Sulforaphane in Premutation Carriers With FXTAS to Find Biomarkers [NCT05233579]		15 participants (Actual)	Interventional	2021-06-25	Completed
Randomized Clinical Trial With Broccoli Sprout Extract to Patients With Type 2 Diabetes [NCT02801448]	Phase 2	103 participants (Actual)	Interventional	2015-09-30	Completed
Salutary Effects of Sulforaphane for Patients With Chronic Kidney Disease [NCT04608903]		122 participants (Anticipated)	Interventional	2021-12-01	Recruiting
A Randomised, Double-blind, Placebo-controlled, Multiple Ascending Dose Study to Evaluate the Safety, Tolerance, Pharmacokinetics and Pharmacodynamics of Sulforadex® in Healthy Male Subjects Following Daily Dosing for 7 Days [NCT02055716]	Phase 1	18 participants (Actual)	Interventional	2014-01-31	Completed
A Double-Blind Placebo-Controlled Trial of a Sulforaphane Nutraceutical to Reduce the Symptoms of Schizophrenia [NCT02810964]	Phase 2	64 participants (Actual)	Interventional	2017-02-22	Completed
A 6-month Study to Evaluate Sulforaphane Effects in Treatment of Cognition Impairment of PD Patients [NCT05084365]	Phase 2	100 participants (Anticipated)	Interventional	2021-11-28	Recruiting
Randomized, Phase II Clinical Trial of Sulforaphane in Bladder Cancer Chemoprevention [NCT03517995]	Phase 2	0 participants (Actual)	Interventional	2020-04-30	Withdrawn(stopped due to Grant not approved)
Prevention of Age-associated Cardiac and Vascular Dysfunction Through Nrf2 Signaling Using the Nutritional Supplement Sulforaphane [NCT05408559]	Phase 1/Phase 2	200 participants (Anticipated)	Interventional	2022-07-01	Recruiting
Safety, Feasibility and Efficacy of Sulforaphane (Avmacol) in Chronic Kidney Disease [NCT05153174]	Phase 1/Phase 2	20 participants (Actual)	Interventional	2022-05-02	Completed
A Dietary Intervention Trial to Examine the Effect of Broccoli Bioactives (Specifically Sulforaphane) on Osteoarthritis (OA) [NCT03878368]		24 participants (Actual)	Interventional	2019-05-01	Completed
A Pilot Study Evaluation of Sulforaphane in Atypical Nevi--Precursor Lesions: Assessment of STAT1 and STAT3 Risk Markers of Melanoma [NCT01568996]	Early Phase 1	17 participants (Actual)	Interventional	2012-08-31	Completed
Broccoli Extract Supplementation and Gastrointestinal Health in Older Adults With Active Alcohol Use and Low Diet Quality [NCT05902754]		40 participants (Anticipated)	Interventional	2023-11-30	Not yet recruiting
A 12-weeks, Randomized, Double-blind, Placebo-controlled Study to Evaluate the Efficacy, Safety and Related Mechanism of Sulforaphane in Treatment of Autism Spectrum Disorder [NCT02879110]		110 participants (Actual)	Interventional	2016-08-31	Completed
A Pre-biopsy Window of Opportunity Trial to Measure the Dietary Bioactive Levels in the Prostate Following an Intervention With Sulforaphane and Allin Dietary Supplements [NCT04046653]		40 participants (Actual)	Interventional	2019-07-03	Completed
Effect of Broccoli Sprout Extract in Patients With Chronic Kidney Disease With Diabetes Type 2 [NCT04858854]		100 participants (Actual)	Interventional	2021-10-10	Completed
Phase II Trial of Effects of the Nutritional Supplement Sulforaphane on Doxorubicin-Associated Cardiac Dysfunction (CRI18-026) [NCT03934905]	Phase 1/Phase 2	70 participants (Anticipated)	Interventional	2022-06-01	Recruiting
Decreasing Risk of Psychosis by Sulforaphane: Study Protocol for a Randomized, Double-blind, Placebo-controlled, Clinical Multicenter Trial (DROPS Trial) [NCT03932136]	Phase 3	300 participants (Anticipated)	Interventional	2019-07-14	Recruiting
Fatty Acid MetabOlism in Individuals Undergoing Sulforaphane Supplementation (FAMOUS) [NCT04364360]		60 participants (Anticipated)	Interventional	2020-01-01	Recruiting
A Pilot Study Evaluating the Bioavailability and Mucosal Bioactivity of the Dietary Supplement, Avmacol®, in Healthy Volunteers With Optimization of Buccal Cell Biomarkers [NCT02800265]		10 participants (Actual)	Interventional	2016-06-16	Completed
Treatment Strategy to Enhance Nrf2 Signaling in Older Adults: Combining Acute Exercise With the Phytochemical Sulforaphane [NCT04848792]		30 participants (Anticipated)	Interventional	2023-02-09	Recruiting
Randomized,Double-blind, Placebo-controlled, Efficacy and Safety Study of Sulforaphane in Patients With Prodromal to Mild Alzheimer's Disease [NCT04213391]		160 participants (Anticipated)	Interventional	2020-05-10	Recruiting
''The PROtective Effect of SulforAphaNe on Chronic Low-grade Inflammation in Healthy Participants'': The PRO SANI Study [NCT05146804]		12 participants (Actual)	Interventional	2021-11-11	Completed
An Examination of Changes in Urinary Metabolites With Use of an Antioxidant Supplement, Sulforaphane, in School-aged Children With Autism [NCT02654743]	Phase 3	21 participants (Actual)	Interventional	2016-01-31	Completed
Broccoli Sprout Extract Effects on the Inflammatory Response to Diesel Exhaust Particles in the Nose [NCT00882115]		38 participants (Actual)	Interventional	2009-07-10	Completed
Effect of Topical Application of Sulforaphane- Containing Broccoli Sprout Extracts on Radiation Dermatitis During External-beam Radiation Therapy for Breast Cancer [NCT00894712]		12 participants (Actual)	Observational	2009-04-15	Completed
Phase 2 Study of the Effect of add-on Sulforaphane in Treatment of Schizophrenia [NCT02880462]	Phase 2	172 participants (Actual)	Interventional	2016-12-26	Completed
Phase I Clinical Trial to Evaluate the Efficacy of Sulforaphane as an Antagonist to Human PXR-mediated Drug-drug Interactions [NCT00621309]	Phase 1	29 participants (Actual)	Interventional	2008-03-31	Completed
Efficacy of Adjunctive Sulforaphane for Depression: Study Protocol for a Randomized, Double-blind, Placebo-controlled Study [NCT04246905]	Phase 2	90 participants (Anticipated)	Interventional	2020-07-15	Recruiting
Sulforaphane-rich Broccoli Sprout Extract for Schizophrenia [NCT01716858]	Phase 2	10 participants (Anticipated)	Interventional	2012-10-31	Completed
A Randomised, Double-blind, Placebo-controlled, Single Ascending Dose Study to Evaluate the Safety, Tolerance, Pharmacokinetics and Pharmacodynamics of Sulforadex® in Healthy Male Subjects [NCT01948362]	Phase 1	29 participants (Actual)	Interventional	2012-11-30	Completed
In Vivo Effects of Sulforaphane Supplementation on Normal Human Prostate [NCT00946309]	Phase 1/Phase 2	45 participants (Actual)	Interventional	2010-07-31	Completed
Broccoli Sprout Extracts in Healthy Volunteers: A Pilot Study of Nrf2 Pathway Modulation in Oral Mucosa [NCT02023931]	Early Phase 1	10 participants (Actual)	Interventional	2014-03-31	Completed
Effect of Topical Sulforaphane on Skin Aging and With Ultraviolet and Visible Light Exposure [NCT03730649]	Early Phase 1	120 participants (Anticipated)	Interventional	2019-10-09	Recruiting
Enhancing Nrf2 by Sulforaphane Treatment in COPD [NCT01335971]	Phase 2	89 participants (Actual)	Interventional	2010-09-30	Completed
Sulforaphane Use to Effect Inflammatory and Metabolic Changes in Virally Suppressed HIV Patients [NCT05224492]	Phase 4	20 participants (Anticipated)	Interventional	2022-02-21	Not yet recruiting
A Comparative Study on Efficacy and Safety of add-on Sulforaphane or rTMS to Escitalopram for Major Depressive Disorder With Poor Response to Initial Treatment [NCT05145270]	Phase 4	180 participants (Anticipated)	Interventional	2019-11-30	Recruiting
Chemoprevention of Prostate Cancer, HDAC Inhibition and DNA Methylation [NCT01265953]		98 participants (Actual)	Interventional	2011-07-31	Completed
Sulforaphane in Autism: A Treatment Trial to Confirm Phenotypic Improvement With Sulforaphane Treatment in a New Jersey (NJ) Population of Individuals With Autism [NCT02677051]	Phase 2	48 participants (Actual)	Interventional	2016-02-29	Active, not recruiting
A 6-month Study to Evaluate Sulforaphane add-on Effects in Treatment of Negative Symptoms and Cognition Impairment of Schizophrenia Patients [NCT04521868]	Phase 2	125 participants (Actual)	Interventional	2020-08-31	Completed
A Pilot Study on Effect of add-on Sulforaphane to SSRIs and Application of Niacin Skin Flush Response Test in Major Depressive Disorder [NCT05148169]	Phase 4	150 participants (Anticipated)	Interventional	2020-01-01	Recruiting
Effects of Sulforaphane on Cognitive Function in Patients With Frontal Brain Damage: Study Protocol for a Randomized Controlled Trial [NCT04252261]	Phase 2	90 participants (Anticipated)	Interventional	2020-06-01	Not yet recruiting
Randomized Clinical Trial of Lung Cancer Chemoprevention With Sulforaphane in Former Smokers [NCT03232138]	Phase 2	67 participants (Actual)	Interventional	2018-01-25	Active, not recruiting
Sulforaphane Supplementation in Atopic Asthmatics [NCT01845493]	Phase 1	16 participants (Actual)	Interventional	2013-04-30	Completed
Sulforaphane Treatment of Children With Autism Spectrum Disorder (ASD) [NCT02561481]	Phase 1/Phase 2	60 participants (Actual)	Interventional	2015-12-31	Completed
Evaluation of the Effect of Sulforaphane in Broccoli Sprouts on Nrf2 Activation, Measures of Oxidative Stress, and Neutrophil Migration to Mucosal Surfaces in Healthy and CF Subjects [NCT01315665]		15 participants (Actual)	Interventional	2011-04-30	Completed
The Effects of Sulforaphane in Patients With Biochemical Recurrence of Prostate Cancer [NCT01228084]	Phase 2	20 participants (Actual)	Interventional	2010-11-30	Completed
A Pilot Project to Validate Digital Bio-markers as a Tool to Measure Improvement in Core Symptoms of Autism During Sulforaphane Treatment. [NCT04805957]		10 participants (Anticipated)	Interventional	2022-07-07	Enrolling by invitation
Effect of Topical Sulforaphane on Skin Fragility Seen in Skin Aging and With Ultraviolet Exposure [NCT03126539]	Phase 2	9 participants (Actual)	Interventional	2017-09-15	Terminated(stopped due to For administrative reasons, we started a new study)
A Phase II, Randomized, Double-blind, Placebo-controlled Study of Myrosinase-enriched Glucoraphanin, a Sulforaphane Precursor System, in Autism Spectrum Disorder [NCT02909959]	Phase 2	48 participants (Actual)	Interventional	2017-03-01	Completed
Sulforaphane-rich Broccoli Sprout Extract for Autism [NCT01474993]	Phase 2	44 participants (Actual)	Interventional	2011-12-31	Completed
Safety, Feasibility, and Tolerability of Sulforaphane in Children With CKD [NCT05653492]	Phase 2	12 participants (Anticipated)	Interventional	2023-05-15	Recruiting
Safety, Feasibility and Efficacy of Sulforaphane (Avmacol Extra Strength) in Chronic Kidney Disease - Randomized, Double-blind, Placebo-controlled Trial [NCT05797506]	Phase 2	100 participants (Anticipated)	Interventional	2023-05-03	Recruiting
The Effect of Broccoli Sprout Extract and Probiotics on Proton Pump Inhibitor-based Triple Therapy for Eradication of Helicobacter Pylori: a Prospective Randomized Trial [NCT03220542]	Phase 4	360 participants (Anticipated)	Interventional	2016-01-31	Active, not recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Trial	Outcome
NCT00621309 (1) [back to overview]	Midazolam Clearance (Pharmacokinetic Measure of Cytochrome P450 3A4 Activity)
NCT00882115 (1) [back to overview]	Total Nasal Cell Count in Response to DEP Challenge at 0, 6 and 24 hr With or Without BSE Intervention
NCT00946309 (4) [back to overview]	3-alpha-diol Gluconate Levels
NCT00946309 (4) [back to overview]	DHT Levels
NCT00946309 (4) [back to overview]	Testosterone Levels
NCT00946309 (4) [back to overview]	Gene Expression of Phase II Enzymes
NCT01228084 (8) [back to overview]	Proportion of Patients Whose PSA Levels Have Not Doubled
NCT01228084 (8) [back to overview]	Proportion of Patients Who Achieve a 50% Decline in Prostate-Specific Antigen (PSA) Levels
NCT01228084 (8) [back to overview]	Percent Change in PSA From Baseline to Final Measured Value at End of Study
NCT01228084 (8) [back to overview]	Minimum Percent Change in PSA (i.e., the Smallest Increase for Those With Increased PSA and the Greatest Decline for Those With Decreased PSA)
NCT01228084 (8) [back to overview]	Incidence of Grade 3 or Higher Treatment Related Toxicity
NCT01228084 (8) [back to overview]	Half-life of Sulforaphane (SFN) in Blood
NCT01228084 (8) [back to overview]	Half-life of SFN in Blood Among Patients With Glutathione-S-Transferase Mu 1 (GSTM1) Null Genotype
NCT01228084 (8) [back to overview]	Half-life of SFN in Blood Among Patients With Glutathione-S-Transferase Mu 1 (GSTM1) Intact Genotype
NCT01265953 (4) [back to overview]	Change of Total Plasma SFN (Sulforaphane) Metabolites Level
NCT01265953 (4) [back to overview]	Change of Total Urine SFN (Sulforaphane) Metabolites
NCT01265953 (4) [back to overview]	Expression of Histone Deacetylase 6 (HDAC6)
NCT01265953 (4) [back to overview]	Percentage of Ki67 Positive Cells up to 8 Weeks Post-randomization
NCT01315665 (4) [back to overview]	Measures of Glutathione From Blood Lymphocytes
NCT01315665 (4) [back to overview]	Measure of Neutrophil Migration Into the Gingival Crevices
NCT01315665 (4) [back to overview]	Nrf2 Activation in Nasal Epithelial Cells
NCT01315665 (4) [back to overview]	Measures of Oxidative Stress in Urine
NCT01335971 (10) [back to overview]	Change From Baseline in Bronchial Epithelial Cell Expression of AKR1C1 at 4 Weeks
NCT01335971 (10) [back to overview]	Change From Baseline in Bronchial Epithelial Cell Expression of AKR1C3 at 4 Weeks
NCT01335971 (10) [back to overview]	Change From Baseline in Bronchial Epithelial Cell Expression of HO1 at 4 Weeks
NCT01335971 (10) [back to overview]	Change From Baseline in Bronchial Epithelial Cell Expression of Nrf2 at 4 Weeks
NCT01335971 (10) [back to overview]	Fold-change in Isoprostane Concentrations (Follow-up to Baseline)
NCT01335971 (10) [back to overview]	Change From Baseline in Alveolar Macrophage Expression of Nrf2 and Associated Genes at 4 Weeks
NCT01335971 (10) [back to overview]	Change From Baseline in Bronchial Epithelial Cell Expression of NQ01 and Keap1 at 4 Weeks
NCT01335971 (10) [back to overview]	Fold-change in Inflammatory Marker Concentrations in Bronchial Alveolar Lavage (Follow-up to Baseline) by Treatment Group
NCT01335971 (10) [back to overview]	Fold-change in Plasma Inflammatory Marker Concentrations (Follow-up to Baseline)
NCT01335971 (10) [back to overview]	Fold-change in Serum Inflammatory Marker Concentrations (Follow-up to Baseline)
NCT01474993 (12) [back to overview]	Renal Function Tests (Serum Creatinine) at 4 Weeks, 18 Weeks and 22 Weeks
NCT01474993 (12) [back to overview]	Thyroid Stimulating Hormone (TSH) at 4 Weeks, 18 Weeks and 22 Weeks
NCT01474993 (12) [back to overview]	Change From Screening/Baseline in Aberrant Behavior Checklist (ABC) at 4 Weeks, 10 Weeks, 18 Weeks and 22 Weeks
NCT01474993 (12) [back to overview]	White Blood Cell (WBC) Count at 4 Weeks, 18 Weeks and 22 Weeks
NCT01474993 (12) [back to overview]	Change From Screening and Baseline in Urinary Isoprostane F2α-VI Levels at 24 Hours After First Dose, at 4 Weeks, 10 Weeks, 18 Weeks and 22 Weeks
NCT01474993 (12) [back to overview]	Change From the Screening Visit in Heat Shock Protein Gene Expression (Relative Maximum Gene Expression) at 24 Hours After First Dose, 18 Weeks and 22 Weeks
NCT01474993 (12) [back to overview]	Change From Screening/Baseline in Social Responsiveness Scale (SRS) at 4 Weeks, 10 Weeks, 18 Weeks and 22 Weeks
NCT01474993 (12) [back to overview]	Liver Function Tests [Serum Glutamic Oxaloacetic Transaminase (SGOT) and Serum Glutamic Pyruvic Transaminase (SGPT)] at 4 Weeks, 18 Weeks and 22 Weeks
NCT01474993 (12) [back to overview]	Ohio Autism Clinical Global Impression Scale - Severity (OACIS-S) Scale at 4 Weeks, 10 Weeks, 18 Weeks and 22 Weeks
NCT01474993 (12) [back to overview]	Ohio Autism Clinical Impressions Scale - Improvement (OACIS-I) (or CGI-I Scores) Scores at 4 Weeks, 10 Weeks, 18 Weeks and 22 Weeks
NCT01474993 (12) [back to overview]	Platelet Count at 4 Weeks, 18 Weeks and 22 Weeks
NCT01474993 (12) [back to overview]	Red Blood Cell (RBC) Count at 4 Weeks, 18 Weeks and 22 Weeks
NCT02561481 (17) [back to overview]	Cox-2
NCT02561481 (17) [back to overview]	Comparison of Free Reduced Glutathione (GSH), Total GSH, Oxidized Glutathione (GSSG) at Week 0 and 15
NCT02561481 (17) [back to overview]	Change in Total SRS-2 Score From Baseline
NCT02561481 (17) [back to overview]	Change in Total Aberrant Behavior Checklist Score From Baseline
NCT02561481 (17) [back to overview]	Change in Ohio Autism Clinical Impressions Scale - Improvement (OACIS-I) Average Score From Baseline
NCT02561481 (17) [back to overview]	HO-1 (Heme Oxygenase 1)
NCT02561481 (17) [back to overview]	HSP27
NCT02561481 (17) [back to overview]	HSP70
NCT02561481 (17) [back to overview]	Free GSH:GSSG and Total GSH:GSSG Ratios at Week 15
NCT02561481 (17) [back to overview]	IL-1β
NCT02561481 (17) [back to overview]	IL-6
NCT02561481 (17) [back to overview]	NQO1: NAD(P)H:Quinone Oxidoreductase-1
NCT02561481 (17) [back to overview]	OACIS-I Response Rate on Aberrant Behaviors Subscale
NCT02561481 (17) [back to overview]	OACIS-I Response Rate on Social Communication Subscale
NCT02561481 (17) [back to overview]	TNF-α
NCT02561481 (17) [back to overview]	xCT
NCT02561481 (17) [back to overview]	Dithiocarbamate Plasma Concentration Detected by Cyclocondensation at Each Visit
NCT02810964 (8) [back to overview]	Change in C-Reactive Protein From the Start to the End of the Study
NCT02810964 (8) [back to overview]	Change in Interferon Gamma From the Start to the End of the Study
NCT02810964 (8) [back to overview]	Change in Anti-Saccharomyces Cerevisiae IgA Class Antibodies From the Start to the End of the Study
NCT02810964 (8) [back to overview]	Change in Tumor Necrosis Factor - Alpha From the Start to the End of the Study
NCT02810964 (8) [back to overview]	Change in Positive and Negative Syndrome Scale (PANSS) Score From the Start to the End of the Double-blind Treatment Phase
NCT02810964 (8) [back to overview]	Change in Pentraxin-3 From the Start to the End of the Study
NCT02810964 (8) [back to overview]	Change in MATRICS Consensus Cognitive Battery (MCCB) Overall Composite Scores From the Start to the End of the Study
NCT02810964 (8) [back to overview]	Change in Interleukin-6 From the Start to the End of the Study
NCT02909959 (47) [back to overview]	Least Squares Mean of Vital Signs (Blood Pressure)
NCT02909959 (47) [back to overview]	Least Squares Mean of Vital Signs (Heart Rate)
NCT02909959 (47) [back to overview]	Least Squares Mean of Vital Signs (Height)
NCT02909959 (47) [back to overview]	Least Squares Mean of Vital Signs (Weight)
NCT02909959 (47) [back to overview]	Mean Absolute Basophils Value
NCT02909959 (47) [back to overview]	Mean Absolute Eosinophils Value
NCT02909959 (47) [back to overview]	Mean Absolute Lymphocytes Value
NCT02909959 (47) [back to overview]	Mean Absolute Monocytes Value
NCT02909959 (47) [back to overview]	Mean Absolute Neutrophils Value
NCT02909959 (47) [back to overview]	Mean Corpuscular Hemoglobin Concentration Value
NCT02909959 (47) [back to overview]	Mean Corpuscular Hemoglobin Value
NCT02909959 (47) [back to overview]	Mean Corpuscular Volume Value
NCT02909959 (47) [back to overview]	Mean Hematocrit Value
NCT02909959 (47) [back to overview]	Mean Hemoglobin Value
NCT02909959 (47) [back to overview]	Mean Liver Function Tests Values (Alanine Transaminase)
NCT02909959 (47) [back to overview]	Mean Liver Function Tests Values (Aspartate Transaminase)
NCT02909959 (47) [back to overview]	Mean Liver Function Tests Values (Total Bilirubin)
NCT02909959 (47) [back to overview]	Mean Platelets Value
NCT02909959 (47) [back to overview]	Mean Red Blood Cell Distribution Width Value
NCT02909959 (47) [back to overview]	Mean Serum Chemistries (Bicarbonate)
NCT02909959 (47) [back to overview]	Mean Serum Chemistries (Blood Urea Nitrogen)
NCT02909959 (47) [back to overview]	Mean Serum Chemistries (Chloride)
NCT02909959 (47) [back to overview]	Mean Serum Chemistries (Creatinine)
NCT02909959 (47) [back to overview]	Mean Serum Chemistries (Glucose)
NCT02909959 (47) [back to overview]	Mean Serum Chemistries (Potassium)
NCT02909959 (47) [back to overview]	Mean Serum Chemistries (Sodium)
NCT02909959 (47) [back to overview]	Mean Value of Thyroid Stimulating Hormone (TSH)
NCT02909959 (47) [back to overview]	Mean White Blood Cell Value
NCT02909959 (47) [back to overview]	Repetitive Behavior Scale-Revised (RBSR) Total Score
NCT02909959 (47) [back to overview]	Social Responsiveness Scale-2 (SRS-2) Subscale Score (Restricted Interests/Repetitive Behaviors)
NCT02909959 (47) [back to overview]	Social Responsiveness Scale-2 (SRS-2) Subscale Score (Social Awareness)
NCT02909959 (47) [back to overview]	Social Responsiveness Scale-2 (SRS-2) Subscale Score (Social Cognition)
NCT02909959 (47) [back to overview]	Mean Red Blood Cell Value
NCT02909959 (47) [back to overview]	Social Responsiveness Scale-2 (SRS-2) Subscale Score (Social Motivation)
NCT02909959 (47) [back to overview]	Number of Participants With Clinical Global Impression-Improvement (CGI-I) Score of Much Improved or Very Much Improved
NCT02909959 (47) [back to overview]	Social Responsiveness Scale-2 (SRS-2) Total Score at Baseline
NCT02909959 (47) [back to overview]	Social Responsiveness Scale-2 (SRS-2) Total Score at Week 12
NCT02909959 (47) [back to overview]	Social Responsiveness Scale-2 (SRS-2) Total Score at Week 16
NCT02909959 (47) [back to overview]	Social Responsiveness Scale-2 (SRS-2) Total Score at Week 4
NCT02909959 (47) [back to overview]	Social Responsiveness Scale-2 (SRS-2) Total Score at Week 8
NCT02909959 (47) [back to overview]	Aberrant Behavior Checklist (ABC) Subscale Score (Inappropriate Speech)
NCT02909959 (47) [back to overview]	Aberrant Behavior Checklist (ABC) Subscale Score (Irritability)
NCT02909959 (47) [back to overview]	Aberrant Behavior Checklist (ABC) Subscale Score (Social Withdrawal)
NCT02909959 (47) [back to overview]	Aberrant Behavior Checklist (ABC) Subscale Score (Stereotypy)
NCT02909959 (47) [back to overview]	Aberrant Behavior Checklist (ABC) Subscale Scores (Hyperactivity)
NCT02909959 (47) [back to overview]	Clinical Global Impression-Severity (CGI-S) Score
NCT02909959 (47) [back to overview]	Social Responsiveness Scale-2 (SRS-2) Subscale Score (Social Communication)
NCT03126539 (1) [back to overview]	Clinical Change Score for Mottled Hyperpigmentation

Midazolam Clearance (Pharmacokinetic Measure of Cytochrome P450 3A4 Activity)

(NCT00621309)
Timeframe: 7 days

Intervention	ng*min/ml (Mean)
	MDZ AUC Day 1	MDZ AUC Day 8
Broccoli Sprout Extract Alone	541	558
Broccoli Sprout Extract Plus Rifampin	552	135
Rifampicin Alone	604	156

Intervention	log cells/mL (Mean)
	0 hr prior DEP dosing (control)	6 hr after DEP dosing (control)	24 hr after DEP dosing (control)	0 hr prior to DEP doising with BSE intervention	6 hr after DEP dosing with BSE intervention	24 hr after DEP dosing with BSE intervention
Nasal DEP Challenge	4.44	4.50	4.73	4.70	4.44	4.57

Intervention	-fold change in expression (Mean)
	Glutathione peroxidase 4 (GPX4) expression	Glutathione S-transferase A2 (GSTa2) expression	NAD(P)H:quinone oxidoreductase (NQ01) expression	RODH5 F2/R2 expression	Superoxide dismutase (SOD1) expression
Placebo	0.26	-0.59	0.42	-0.02	0.5
Sulforaphane	-0.36	0.15	-0.02	-0.10	0.35

Intervention	participants (Number)
	Baseline	Day 5, End of treatment
Healthy Volunteers	0	4
Subjects With Cystic Fibrosis	0	4

Intervention	fold change (Median)
	NQ01	HO1	AKR1C1	AKR1C3	Nrf2	Keap1
Placebo	0.80	0.90	0.81	1.03	1.14	0.94
Sulforaphane 150	0.94	1.06	0.71	0.87	1.13	1.06
Sulforaphane 25	1.03	0.98	1.13	1.02	1.05	0.99

Intervention	fold change (Median)
	Interleukin-8 (pg/mg)	Secretory leukoprotease inhibitor (pg/mg)
Placebo	1.22	1.51
Sulforaphane 150	1.11	1.12
Sulforaphane 25	0.94	1.09

Intervention	fold change (Median)
	Isoprostane (ng/mg)	Thiobarbituric acid reactive substances	Total antioxidants (mM Trolox equivalents/L)
Placebo	0.89	0.96	0.97
Sulforaphane 150	0.88	1.06	0.97
Sulforaphane 25	0.90	1.05	0.92

Intervention	fold change (Median)
	C-reactive protein (mg/L)	Interleukin-6 (pg/mL)	Interleukin-8 (pg/mL)
Placebo	0.99	0.75	1.06
Sulforaphane 150	1.01	1.12	1.03
Sulforaphane 25	0.90	0.90	1.04

Intervention	mg/dL (Mean)
	Serum Creatinine at 4 weeks	Serum Creatinine at 18 weeks	Serum Creatinine at 22 weeks
Placebo	0.8	0.8	0.8
Sulforaphane-rich Broccoli Sprout Extract	0.8	0.8	0.8

Intervention	uIU/mL (Mean)
	TSH 4 weeks	TSH 18 weeks	TSH 22 weeks
Placebo	1.8	1.5	1.2
Sulforaphane-rich Broccoli Sprout Extract	1.8	1.9	1.7

Intervention	units on a scale (Mean)
	Change from screening/baseline at 4 weeks	Change from screening/baseline at 10 weeks	Change from screening/baseline at 18 weeks	Change from screening/baseline at 22 weeks
Placebo	0.77	3.31	-2.0	-1.83
Sulforaphane-rich Broccoli Sprout Extract	-12.69	-19.61	-21.44	-10.72

Intervention	*10^3 cells/µL (Mean)
	WBC count at 4 weeks	WBC count at 18 weeks	WBC count at 22 weeks
Placebo	6.63	6.33	6.12
Sulforaphane-rich Broccoli Sprout Extract	6.32	5.94	6.18

Intervention	U/L (Mean)
	SGOT 4 weeks	SGOT 18 weeks	SGOT 22 weeks	SGPT 4 weeks	SGPT 18 weeks	SGPT 22 weeks
Placebo	27.6	22.5	21.8	25.1	22.2	21
Sulforaphane-rich Broccoli Sprout Extract	23.8	22.5	25.4	23.8	31.1	37.7

Intervention	units on a scale (Mean)
	OACIS-S general level of autism 4 weeks	OACIS-S general level of autism 10 weeks	OACIS-S general level of autism 18 weeks	OACIS-S general level of autism 22 weeks	OACIS-S social interaction 4 weeks	OACIS-S social interaction 10 weeks	OACIS-S social interaction 18 weeks	OACIS-S social interaction 22 weeks	OACIS-S aberrant behavior 4 weeks	OACIS-S aberrant behavior 10 weeks	OACIS-S aberrant behavior 18 weeks	OACIS-S aberrant behavior 22 weeks	OACIS-S repetitive behavior 4 weeks	OACIS-S repetitive behavior 10 weeks	OACIS-S repetitive behavior 18 weeks	OACIS-S repetitive behavior 22 weeks	OACIS-S verbal communication 4 weeks	OACIS-S verbal communication 10 weeks	OACIS-S verbal communication 18 weeks	OACIS-S verbal communication 22 weeks	OACIS-S non-verbal communication 4 weeks	OACIS-S non-verbal communication 10 weeks	OACIS-S non-verbal communication 18 weeks	OACIS-S non-verbal communication 22 weeks	OACIS-S hyperactivity 4 weeks	OACIS-S hyperactivity 10 weeks	OACIS-S hyperactivity 18 weeks	OACIS-S hyperactivity 22 weeks	OACIS-S anxiety 4 weeks	OACIS-S anxiety 10 weeks	OACIS-S anxiety 18 weeks	OACIS-S anxiety 22 weeks	OACIS-S sensory sensitivity 4 weeks	OACIS-S sensory sensitivity 10 weeks	OACIS-S sensory sensitivity 18 weeks	OACIS-S sensory sensitivity 22 weeks	OACIS-S restricted interests 4 weeks	OACIS-S restricted interests 10 weeks	OACIS-S restricted interests 18 weeks	OACIS-S restricted interests 22 weeks
Placebo	4.36	4.43	4.50	4.70	4.50	4.57	4.71	5.0	4.36	4.29	4.43	4.90	3.86	4.14	4.14	4.30	4.43	4.21	4.71	5.20	4.29	4.23	4.43	4.40	4.36	4.07	4.29	4.20	4.21	4.43	4.36	4.50	4.36	4.43	4.57	4.60	4.07	4.00	4.21	4.50
Sulforaphane-rich Broccoli Sprout Extract	4.38	4.31	4.42	4.50	3.77	3.46	3.46	4.60	3.73	3.27	3.19	4.35	4.08	3.62	3.69	4.55	3.73	3.73	3.54	4.80	3.85	3.73	3.69	4.25	3.50	3.54	3.58	4.25	3.81	3.69	3.85	4.20	4.08	4.00	4.04	4.20	4.27	3.92	3.92	4.55

Intervention	units on a scale (Mean)
	OACIS-I general level of autism 4 weeks	OACIS-I general level of autism 10 weeks	OACIS-I general level of autism 18 weeks	OACIS-I general level of autism 22 weeks	OACIS-I social interaction 4 weeks	OACIS-I social interaction 10 weeks	OACIS-I social interaction 18 weeks	OACIS-I social interaction 22 weeks	OACIS-I aberrant behavior 4 weeks	OACIS-I aberrant behavior 10 weeks	OACIS-I aberrant behavior 18 weeks	OACIS-I aberrant behavior 22 weeks	OACIS-I repetitive behavior 4 weeks	OACIS-I repetitive behavior 10 weeks	OACIS-I repetitive behavior 18 weeks	OACIS-I repetitive behavior 22 weeks	OACIS-I verbal communication 4 weeks	OACIS-I verbal communication 10 weeks	OACIS-I verbal communication 18 weeks	OACIS-I verbal communication 22 weeks	OACIS-I non-verbal communication 4 weeks	OACIS-I non-verbal communication 10 weeks	OACIS-I non-verbal communication 18 weeks	OACIS-I non-verbal communication 22 weeks	OACIS-I hyperactivity 4 weeks	OACIS-I hyperactivity 10 weeks	OACIS-I hyperactivity 18 weeks	OACIS-I hyperactivity 22 weeks	OACIS-I anxiety 4 weeks	OACIS-I anxiety 10 weeks	OACIS-I anxiety 18 weeks	OACIS-I anxiety 22 weeks	OACIS-I sensory sensitivity 4 weeks	OACIS-I sensory sensitivity 10 weeks	OACIS-I sensory sensitivity 18 weeks	OACIS-I sensory sensitivity 22 weeks	OACIS-I restricted interests 4 weeks	OACIS-I restricted interests 10 weeks	OACIS-I restricted interests 18 weeks	OACIS-I restricted interests 22 weeks
Placebo	4.14	3.86	3.93	4.0	3.71	3.79	3.92	4.1	3.86	3.79	3.93	4.2	3.71	4	4	4.1	3.57	3.36	3.86	4	3.93	3.92	4.07	4	4	3.71	3.93	3.8	4	4.21	4.14	4.2	3.86	3.93	4.07	4	3.86	3.79	4	4.1
Sulforaphane-rich Broccoli Sprout Extract	4.04	3.88	3.81	3.92	3.38	3.08	3.08	4.2	3.42	2.96	2.88	4.1	3.81	3.35	3.42	4.25	3.15	3.16	2.96	4.15	3.69	3.58	3.54	4	3.42	3.46	3.5	4.05	3.65	3.54	3.69	4	3.85	3.77	3.81	4	3.81	3.46	3.46	4.05

Intervention	*10^3 cells/µL (Mean)
	Platelet count at 4 weeks	Platelet count at 18 weeks	Platelet count at 22 weeks
Placebo	242.1	236.8	218.1
Sulforaphane-rich Broccoli Sprout Extract	235.0	237.1	255.0

Intervention	*10^6 cells/µL (Mean)
	RBC count at 4 weeks	RBC count at 18 weeks	RBC count at 22 weeks
Placebo	5.13	5.03	5.12
Sulforaphane-rich Broccoli Sprout Extract	5.11	5.13	5.04

Intervention	log fold change (Mean)
	Week 0	Week 15	Week 30
Placebo	-0.20	0.16	-0.17
Sulforaphane	0.14	-0.07	-0.46

Intervention	F-statistic (Number)
	Free Reduced GSH	Total GSH	GSSG
Placebo	0.11	0.08	0.46
Sulforaphane	1.51	0.00	1.97

Intervention	score on a scale (Mean)
	7 weeks	15 weeks	22 weeks	30 weeks	36 weeks
Placebo	-8.06	-7.92	-13.67	-18.59	-19.59
Sulforaphane	1.14	-16.86	-14.61	-19.83	0.80

Intervention	F-statistic (Number)
	Free GSH:GSSG	Total GSH:GSSG
Placebo	0.87	0.03
Sulforaphane	12.72	5.16

sulforaphane

Description

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Synonyms (60)

Research Excerpts

Overview

Effects

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Treatment

Toxicity

Pharmacokinetics

Compound-Compound Interactions

Bioavailability

Dosage Studied

Occurs in Manufacturing (3 Product(s))

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Products

Roles (4)

Drug Classes (2)

Pathways (3)

Protein Targets (13)

Inhibition Measurements

Activation Measurements

Other Measurements

Biological Processes (198)

Molecular Functions (53)

Ceullar Components (49)

Bioassays (367)

Research

Studies (1,719)

Market Indicators

Research Demand Index: 49.72

Study Types

Clinical Trials (53)

Trial Overview

Trial Outcomes

Midazolam Clearance (Pharmacokinetic Measure of Cytochrome P450 3A4 Activity)

Total Nasal Cell Count in Response to DEP Challenge at 0, 6 and 24 hr With or Without BSE Intervention

3-alpha-diol Gluconate Levels

DHT Levels

Testosterone Levels

Gene Expression of Phase II Enzymes

Proportion of Patients Whose PSA Levels Have Not Doubled

Proportion of Patients Who Achieve a 50% Decline in Prostate-Specific Antigen (PSA) Levels

Percent Change in PSA From Baseline to Final Measured Value at End of Study

Minimum Percent Change in PSA (i.e., the Smallest Increase for Those With Increased PSA and the Greatest Decline for Those With Decreased PSA)

Incidence of Grade 3 or Higher Treatment Related Toxicity

Half-life of Sulforaphane (SFN) in Blood

Half-life of SFN in Blood Among Patients With Glutathione-S-Transferase Mu 1 (GSTM1) Null Genotype

Half-life of SFN in Blood Among Patients With Glutathione-S-Transferase Mu 1 (GSTM1) Intact Genotype

Change of Total Plasma SFN (Sulforaphane) Metabolites Level

Change of Total Urine SFN (Sulforaphane) Metabolites

Expression of Histone Deacetylase 6 (HDAC6)

Percentage of Ki67 Positive Cells up to 8 Weeks Post-randomization

Measures of Glutathione From Blood Lymphocytes

Measure of Neutrophil Migration Into the Gingival Crevices

Nrf2 Activation in Nasal Epithelial Cells

Measures of Oxidative Stress in Urine

Change From Baseline in Bronchial Epithelial Cell Expression of AKR1C1 at 4 Weeks

Change From Baseline in Bronchial Epithelial Cell Expression of AKR1C3 at 4 Weeks

Change From Baseline in Bronchial Epithelial Cell Expression of HO1 at 4 Weeks

Change From Baseline in Bronchial Epithelial Cell Expression of Nrf2 at 4 Weeks

Fold-change in Isoprostane Concentrations (Follow-up to Baseline)

Change From Baseline in Alveolar Macrophage Expression of Nrf2 and Associated Genes at 4 Weeks

Change From Baseline in Bronchial Epithelial Cell Expression of NQ01 and Keap1 at 4 Weeks

Fold-change in Inflammatory Marker Concentrations in Bronchial Alveolar Lavage (Follow-up to Baseline) by Treatment Group

Fold-change in Plasma Inflammatory Marker Concentrations (Follow-up to Baseline)

Fold-change in Serum Inflammatory Marker Concentrations (Follow-up to Baseline)

Renal Function Tests (Serum Creatinine) at 4 Weeks, 18 Weeks and 22 Weeks

Thyroid Stimulating Hormone (TSH) at 4 Weeks, 18 Weeks and 22 Weeks

Change From Screening/Baseline in Aberrant Behavior Checklist (ABC) at 4 Weeks, 10 Weeks, 18 Weeks and 22 Weeks

White Blood Cell (WBC) Count at 4 Weeks, 18 Weeks and 22 Weeks

Change From Screening and Baseline in Urinary Isoprostane F2α-VI Levels at 24 Hours After First Dose, at 4 Weeks, 10 Weeks, 18 Weeks and 22 Weeks

Change From the Screening Visit in Heat Shock Protein Gene Expression (Relative Maximum Gene Expression) at 24 Hours After First Dose, 18 Weeks and 22 Weeks

Change From Screening/Baseline in Social Responsiveness Scale (SRS) at 4 Weeks, 10 Weeks, 18 Weeks and 22 Weeks

Liver Function Tests [Serum Glutamic Oxaloacetic Transaminase (SGOT) and Serum Glutamic Pyruvic Transaminase (SGPT)] at 4 Weeks, 18 Weeks and 22 Weeks

Ohio Autism Clinical Global Impression Scale - Severity (OACIS-S) Scale at 4 Weeks, 10 Weeks, 18 Weeks and 22 Weeks

Ohio Autism Clinical Impressions Scale - Improvement (OACIS-I) (or CGI-I Scores) Scores at 4 Weeks, 10 Weeks, 18 Weeks and 22 Weeks

Platelet Count at 4 Weeks, 18 Weeks and 22 Weeks

Intervention	log fold change (Mean)
	Week 0 (baseline)	Week 15	Week 30
Placebo	2.25	2.14	2.13
Sulforaphane	2.23	2.19	2.15

Intervention	nmol DTC (Dithiocarbamates)/ml (Mean)
	Week 0	Week 7	Week 15	Week 22	Week 30	Week 36
Placebo	0.006	0.003	0.005	0.205	0.214	0.008
Sulforaphane	0.007	0.299	0.329	0.248	0.165	0.015

Intervention	ng/ml (Mean)
	CRP (Wk 0, Baseline)	CRP (Wk 18, End Treatment)
Identical-appearing Placebo	8969.7	10224.5
Sulforaphane Nutraceutical	10402.8	10198.5

Intervention	pg/m (Mean)
	IFN-g (Wk 0, Baseline)	IFN-g (Wk 18, End Treatment)
Identical-appearing Placebo	0.456	0.526
Sulforaphane Nutraceutical	0.514	0.478

Intervention	units/ml (Mean)
	ASCA IGA (Wk 0, Baseline)	ASCA IGA (Wk 18, End Treatment)
Identical-appearing Placebo	0.168	0.176
Sulforaphane Nutraceutical	0.195	0.226

Intervention	pg/m (Mean)
	TNF-a (Wk 0, Baseline)	TNF-a (Wk 18, End Treatment)
Identical-appearing Placebo	0.538	0.520
Sulforaphane Nutraceutical	0.668	0.638

Intervention	score on a scale (Mean)
	Wk 2 (Begin Treatment) PANSS Total Score	Wk 18 (End Treatment) PANSS Total Score
Identical-appearing Placebo	81.5	79.7
Sulforaphane Nutraceutical	81.0	81.7

Intervention	ng/ml (Mean)
	Pentraxin(Wk 0, Baseline)	Pentraxin (Wk 18, End Treatment)
Identical-appearing Placebo	0.461	0.558
Sulforaphane Nutraceutical	0.414	0.394

Intervention	t scores (Mean)
	Wk 0 (Baseline) MCCB Score	Wk 18 (End Treatment) MCCB Score
Identical-appearing Placebo	19.5	22.8
Sulforaphane Nutraceutical	25.0	26.8

Intervention	pg/m (Mean)
	IL-6 (Wk 0, Baseline)	IL-6 (Wk 18, End Treatment)
Identical-appearing Placebo	0.704	0.673
Sulforaphane Nutraceutical	0.623	0.694