Page last updated: 2024-08-07 15:51:06

Wee1-like protein kinase 2

A Wee1-like protein kinase 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P0C1S8]

Synonyms

EC 2.7.10.2;
Wee1-like protein kinase 1B;
Wee1B kinase

Research

Bioassay Publications (3)

TimeframeStudies on this Protein(%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (33.33)29.6817
2010's2 (66.67)24.3611
2020's0 (0.00)2.80

Compounds (73)

Drugs with Activation Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
imatinibHomo sapiens (human)Kd10.000011
staurosporineHomo sapiens (human)Kd10.000011
gefitinibHomo sapiens (human)Kd10.000011
lestaurtinibHomo sapiens (human)Kd8.950022
vatalanibHomo sapiens (human)Kd10.000011
ruboxistaurinHomo sapiens (human)Kd10.000011
canertinibHomo sapiens (human)Kd10.000011
birb 796Homo sapiens (human)Kd10.000011
sb 203580Homo sapiens (human)Kd10.000011
enzastaurinHomo sapiens (human)Kd10.000011
erlotinibHomo sapiens (human)Kd10.000011
lapatinibHomo sapiens (human)Kd10.000011
sorafenibHomo sapiens (human)Kd10.000022
pd 173955Homo sapiens (human)Kd0.057011
s 1033Homo sapiens (human)Kd10.000011
bms 387032Homo sapiens (human)Kd10.000011
tandutinibHomo sapiens (human)Kd10.000022
vx-745Homo sapiens (human)Kd10.000011
dasatinibHomo sapiens (human)Kd0.340522
zd 6474Homo sapiens (human)Kd10.000011
alvocidibHomo sapiens (human)Kd10.000011
pd 166285Homo sapiens (human)Kd0.005011
bosutinibHomo sapiens (human)Kd0.100022
su 11248Homo sapiens (human)Kd10.000022
vx680Homo sapiens (human)Kd4.200011
ekb 569Homo sapiens (human)Kd0.498011
axitinibHomo sapiens (human)Kd10.000011
pd 184352Homo sapiens (human)Kd10.000011
bms345541Homo sapiens (human)Kd10.000011
midostaurinHomo sapiens (human)Kd10.000022
ki 20227Homo sapiens (human)Kd10.000011
pi103Homo sapiens (human)Kd10.000011
hki 272Homo sapiens (human)Kd1.300011
tofacitinibHomo sapiens (human)Kd10.000011
n-(6-chloro-7-methoxy-9h-beta-carbolin-8-yl)-2-methylnicotinamideHomo sapiens (human)Kd10.000011
cediranibHomo sapiens (human)Kd10.000011
masitinibHomo sapiens (human)Kd10.000011
pazopanibHomo sapiens (human)Kd10.000011
azd 6244Homo sapiens (human)Kd10.000011
su 14813Homo sapiens (human)Kd10.000011
bibw 2992Homo sapiens (human)Kd10.000011
tg100-115Homo sapiens (human)Kd10.000011
pha 665752Homo sapiens (human)Kd10.000011
6-[[5-fluoro-2-(3,4,5-trimethoxyanilino)-4-pyrimidinyl]amino]-2,2-dimethyl-4H-pyrido[3,2-b][1,4]oxazin-3-oneHomo sapiens (human)Kd9.400011
brivanibHomo sapiens (human)Kd10.000011
at 7519Homo sapiens (human)Kd10.000011
bi 2536Homo sapiens (human)Kd10.000011
nvp-ast487Homo sapiens (human)Kd10.000011
kw 2449Homo sapiens (human)Kd4.700011
abt 869Homo sapiens (human)Kd10.000011
gw 2580Homo sapiens (human)Kd10.000011
crizotinibHomo sapiens (human)Kd10.000011
chir-265Homo sapiens (human)Kd10.000011
motesanibHomo sapiens (human)Kd10.000011
mln8054Homo sapiens (human)Kd10.000011
GDC-0879Homo sapiens (human)Kd10.000011
gsk 461364Homo sapiens (human)Kd10.000011
azd 1152-hqpaHomo sapiens (human)Kd10.000011
nvp-tae684Homo sapiens (human)Kd10.000011
pha 848125Homo sapiens (human)Kd0.026611
fedratinibHomo sapiens (human)Kd6.000011
gsk690693Homo sapiens (human)Kd10.000011
gdc 0941Homo sapiens (human)Kd10.000011
plx 4720Homo sapiens (human)Kd10.000011
sgx 523Homo sapiens (human)Kd10.000011
mk-1775Homo sapiens (human)Kd0.015422
quizartinibHomo sapiens (human)Kd10.000022
incb-018424Homo sapiens (human)Kd10.000011
gsk 1838705aHomo sapiens (human)Kd10.000011
gsk 1363089Homo sapiens (human)Kd10.000011
chir 258Homo sapiens (human)Kd10.000011
nintedanibHomo sapiens (human)Kd10.000011
pp242Homo sapiens (human)Kd10.000011

Enables

This protein enables 4 target(s):

TargetCategoryDefinition
magnesium ion bindingmolecular functionBinding to a magnesium (Mg) ion. [GOC:ai]
non-membrane spanning protein tyrosine kinase activitymolecular functionCatalysis of the reaction: ATP + protein L-tyrosine = ADP + protein L-tyrosine phosphate by a non-membrane spanning protein. [EC:2.7.10.2]
ATP bindingmolecular functionBinding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. [ISBN:0198506732]
protein tyrosine kinase activitymolecular functionCatalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. [RHEA:10596]

Located In

This protein is located in 3 target(s):

TargetCategoryDefinition
nucleoplasmcellular componentThat part of the nuclear content other than the chromosomes or the nucleolus. [GOC:ma, ISBN:0124325653]
cytosolcellular componentThe part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]
plasma membranecellular componentThe membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]

Active In

This protein is active in 2 target(s):

TargetCategoryDefinition
cytoplasmcellular componentThe contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684]
nucleuscellular componentA membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators]

Involved In

This protein is involved in 8 target(s):

TargetCategoryDefinition
mitotic cell cyclebiological processProgression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent. [GOC:mah, ISBN:0815316194, Reactome:69278]
female meiotic nuclear divisionbiological processA cell cycle process by which the cell nucleus divides as part of a meiotic cell cycle in the female germline. [GOC:dph, GOC:ems, GOC:mah, GOC:vw]
female pronucleus assemblybiological processAssembly of the haploid nucleus of the unfertilized egg. [GOC:bf, ISBN:0582227089]
positive regulation of phosphorylationbiological processAny process that activates or increases the frequency, rate or extent of addition of phosphate groups to a molecule. [GOC:jl]
regulation of meiosis Ibiological processAny process that modulates the rate, frequency, or extent of meiosis I, a cell cycle process comprising the steps by which a cell progresses through the first phase of meiosis, in which cells divide and homologous chromosomes are paired and segregated from each other, producing two daughter cells. [GOC:dph, GOC:tb]
regulation of fertilizationbiological processAny process that modulates the rate, frequency or extent of fertilization. Fertilization is the union of gametes of opposite sexes during the process of sexual reproduction to form a zygote. It involves the fusion of the gametic nuclei (karyogamy) and cytoplasm (plasmogamy). [GOC:DHL, PMID:20478994]
negative regulation of oocyte maturationbiological processAny process that stops, prevents or reduces the frequency, rate or extent of oocyte maturation. [GOC:kmv, GOC:TermGenie]
protein phosphorylationbiological processThe process of introducing a phosphate group on to a protein. [GOC:hb]