A spermine oxidase that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NWM0]
EC 1.5.3.16;
Polyamine oxidase 1;
PAO-1;
PAOh1
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| N5-(2-chloro-6-phenoxybenzyl)-1H-1,2,4-triazole-3,5-diamine | Homo sapiens (human) | IC50 | 88.9700 | 2 | 2 |
| mdl 72527 | Homo sapiens (human) | IC50 | 89.7000 | 1 | 1 |
| chlorhexidine | Homo sapiens (human) | Ki | 0.3250 | 1 | 2 |
This protein enables 4 target(s):
| Target | Category | Definition |
|---|---|---|
| polyamine oxidase activity | molecular function | Catalysis of the oxidative degradation or interconversion of polyamines. [PMID:1567380] |
| norspermine:oxygen oxidoreductase activity | molecular function | Catalysis of the reaction: norspermine + oxygen + H2O = norspermidine + 3-aminopropanal + hydrogen peroxide. [MetaCyc:RXN-10464] |
| N1-acetylspermine:oxygen oxidoreductase (N1-acetylspermidine-forming) activity | molecular function | Catalysis of the reaction: N1-acetylspermine + oxygen + H2O = N1-acetylspermidine + 3-aminopropanal + hydrogen peroxide. [MetaCyc:POLYAMINE-OXIDASE-RXN] |
| spermine:oxygen oxidoreductase (spermidine-forming) activity | molecular function | Catalysis of the reaction: H2O + O2 + spermine = 3-aminopropanal + H2O2 + spermidine. [RHEA:25804] |
This protein is located in 4 target(s):
| Target | Category | Definition |
|---|---|---|
| nucleoplasm | cellular component | That part of the nuclear content other than the chromosomes or the nucleolus. [GOC:ma, ISBN:0124325653] |
| cytosol | cellular component | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl] |
| nuclear membrane | cellular component | Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space. [GOC:mah, GOC:pz] |
| intracellular membrane-bounded organelle | cellular component | Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane. [GOC:go_curators] |
This protein is involved in 4 target(s):
| Target | Category | Definition |
|---|---|---|
| polyamine biosynthetic process | biological process | The chemical reactions and pathways resulting in the formation of polyamines, any organic compound containing two or more amino groups. [ISBN:0198506732] |
| polyamine catabolic process | biological process | The chemical reactions and pathways resulting in the breakdown of polyamines, any organic compound containing two or more amino groups. [ISBN:0198506732] |
| xenobiotic metabolic process | biological process | The chemical reactions and pathways involving a xenobiotic compound, a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical. [GOC:cab2, GOC:krc] |
| spermine catabolic process | biological process | The chemical reactions and pathways resulting in the breakdown of spermine, a polybasic amine found in human sperm, in ribosomes and in some viruses and involved in nucleic acid packaging. [PMID:12141946] |