Page last updated: 2024-08-07 21:22:21

Spermine oxidase

A spermine oxidase that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NWM0]

Synonyms

EC 1.5.3.16;
Polyamine oxidase 1;
PAO-1;
PAOh1

Research

Bioassay Publications (3)

TimeframeStudies on this Protein(%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's3 (100.00)24.3611
2020's0 (0.00)2.80

Compounds (3)

Drugs with Inhibition Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
N5-(2-chloro-6-phenoxybenzyl)-1H-1,2,4-triazole-3,5-diamineHomo sapiens (human)IC5088.970022
mdl 72527Homo sapiens (human)IC5089.700011
chlorhexidineHomo sapiens (human)Ki0.325012

Enables

This protein enables 4 target(s):

TargetCategoryDefinition
polyamine oxidase activitymolecular functionCatalysis of the oxidative degradation or interconversion of polyamines. [PMID:1567380]
norspermine:oxygen oxidoreductase activitymolecular functionCatalysis of the reaction: norspermine + oxygen + H2O = norspermidine + 3-aminopropanal + hydrogen peroxide. [MetaCyc:RXN-10464]
N1-acetylspermine:oxygen oxidoreductase (N1-acetylspermidine-forming) activitymolecular functionCatalysis of the reaction: N1-acetylspermine + oxygen + H2O = N1-acetylspermidine + 3-aminopropanal + hydrogen peroxide. [MetaCyc:POLYAMINE-OXIDASE-RXN]
spermine:oxygen oxidoreductase (spermidine-forming) activitymolecular functionCatalysis of the reaction: H2O + O2 + spermine = 3-aminopropanal + H2O2 + spermidine. [RHEA:25804]

Located In

This protein is located in 4 target(s):

TargetCategoryDefinition
nucleoplasmcellular componentThat part of the nuclear content other than the chromosomes or the nucleolus. [GOC:ma, ISBN:0124325653]
cytosolcellular componentThe part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]
nuclear membranecellular componentEither of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space. [GOC:mah, GOC:pz]
intracellular membrane-bounded organellecellular componentOrganized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane. [GOC:go_curators]

Involved In

This protein is involved in 4 target(s):

TargetCategoryDefinition
polyamine biosynthetic processbiological processThe chemical reactions and pathways resulting in the formation of polyamines, any organic compound containing two or more amino groups. [ISBN:0198506732]
polyamine catabolic processbiological processThe chemical reactions and pathways resulting in the breakdown of polyamines, any organic compound containing two or more amino groups. [ISBN:0198506732]
xenobiotic metabolic processbiological processThe chemical reactions and pathways involving a xenobiotic compound, a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical. [GOC:cab2, GOC:krc]
spermine catabolic processbiological processThe chemical reactions and pathways resulting in the breakdown of spermine, a polybasic amine found in human sperm, in ribosomes and in some viruses and involved in nucleic acid packaging. [PMID:12141946]