Page last updated: 2024-08-07 23:34:21
Nuclear receptor ROR-gamma
A nuclear receptor ROR-gamma that is encoded in the genome of human. [PRO:WCB, UniProtKB:P51449]
Synonyms
Nuclear receptor RZR-gamma;
Nuclear receptor subfamily 1 group F member 3;
RAR-related orphan receptor C;
Retinoid-related orphan receptor-gamma
Research
Bioassay Publications (20)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 15 (75.00) | 24.3611 |
| 2020's | 5 (25.00) | 2.80 |
Compounds (424)
Drugs with Potency Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| 1,2,4-trichlorobenzene | Homo sapiens (human) | Potency | 3.7578 | 1 | 0 |
| anthranilic acid | Homo sapiens (human) | Potency | 16.7855 | 1 | 0 |
| butyraldehyde | Homo sapiens (human) | Potency | 33.4915 | 1 | 0 |
| catechol | Homo sapiens (human) | Potency | 5.9557 | 1 | 0 |
| chlordecone | Homo sapiens (human) | Potency | 10.0150 | 1 | 0 |
| 4-aminophenol | Homo sapiens (human) | Potency | 42.1632 | 1 | 0 |
| 3-chlorobenzoic acid | Homo sapiens (human) | Potency | 0.1496 | 1 | 0 |
| guaiacol | Homo sapiens (human) | Potency | 0.1496 | 1 | 0 |
| ethyl 2-methyl-3-oxobutanoate | Homo sapiens (human) | Potency | 0.0047 | 1 | 0 |
| hydroquinone | Homo sapiens (human) | Potency | 10.5909 | 1 | 0 |
| imidazole | Homo sapiens (human) | Potency | 33.4915 | 1 | 0 |
| thioctic acid | Homo sapiens (human) | Potency | 66.8242 | 1 | 0 |
| melatonin | Homo sapiens (human) | Potency | 58.5706 | 1 | 0 |
| pentachlorophenol | Homo sapiens (human) | Potency | 16.7855 | 1 | 0 |
| phthalic acid | Homo sapiens (human) | Potency | 16.7855 | 1 | 0 |
| propylene glycol | Homo sapiens (human) | Potency | 7.4978 | 1 | 0 |
| 1,10-phenanthroline | Homo sapiens (human) | Potency | 2.3710 | 1 | 0 |
| 2,4,6-tribromophenol | Homo sapiens (human) | Potency | 74.9780 | 1 | 0 |
| 2,4-dinitrophenol | Homo sapiens (human) | Potency | 6.6824 | 1 | 0 |
| chlorocresol | Homo sapiens (human) | Potency | 21.1317 | 1 | 0 |
| 4-nonylphenol | Homo sapiens (human) | Potency | 66.8242 | 1 | 0 |
| oxyquinoline | Homo sapiens (human) | Potency | 3.3491 | 1 | 0 |
| acetaminophen | Homo sapiens (human) | Potency | 21.1317 | 1 | 0 |
| alachlor | Homo sapiens (human) | Potency | 37.5780 | 1 | 0 |
| theophylline | Homo sapiens (human) | Potency | 42.1632 | 1 | 0 |
| anthralin | Homo sapiens (human) | Potency | 29.8493 | 1 | 0 |
| aspirin | Homo sapiens (human) | Potency | 8.4127 | 1 | 0 |
| atrazine | Homo sapiens (human) | Potency | 2.6603 | 1 | 0 |
| azathioprine | Homo sapiens (human) | Potency | 37.5780 | 1 | 0 |
| azinphosmethyl | Homo sapiens (human) | Potency | 29.8493 | 1 | 0 |
| 2,2-bis(4-glycidyloxyphenyl)propane | Homo sapiens (human) | Potency | 23.7101 | 1 | 0 |
| propiolactone | Homo sapiens (human) | Potency | 47.3079 | 1 | 0 |
| bisacodyl | Homo sapiens (human) | Potency | 0.0750 | 1 | 0 |
| bithionol | Homo sapiens (human) | Potency | 4.7308 | 1 | 0 |
| butamben | Homo sapiens (human) | Potency | 1.6785 | 1 | 0 |
| camphor, (+-)-isomer | Homo sapiens (human) | Potency | 0.0841 | 1 | 0 |
| celecoxib | Homo sapiens (human) | Potency | 33.4915 | 1 | 0 |
| chlorambucil | Homo sapiens (human) | Potency | 66.8242 | 1 | 0 |
| chlorpyrifos | Homo sapiens (human) | Potency | 33.4915 | 1 | 0 |
| clioquinol | Homo sapiens (human) | Potency | 23.7101 | 1 | 0 |
| 4-cresol | Homo sapiens (human) | Potency | 10.5909 | 1 | 0 |
| danthron | Homo sapiens (human) | Potency | 37.5780 | 1 | 0 |
| dapsone | Homo sapiens (human) | Potency | 33.4915 | 1 | 0 |
| decanoic acid | Homo sapiens (human) | Potency | 84.1267 | 1 | 0 |
| dibutyl phthalate | Homo sapiens (human) | Potency | 6.6824 | 1 | 0 |
| dichlorodiphenyl dichloroethylene | Homo sapiens (human) | Potency | 35.5348 | 1 | 0 |
| ddt | Homo sapiens (human) | Potency | 74.9780 | 1 | 0 |
| dichlorophen | Homo sapiens (human) | Potency | 26.6032 | 1 | 0 |
| dichlorvos | Homo sapiens (human) | Potency | 47.3079 | 1 | 0 |
| benzophenone | Homo sapiens (human) | Potency | 74.9780 | 1 | 0 |
| valproic acid | Homo sapiens (human) | Potency | 66.8242 | 1 | 0 |
| emodin | Homo sapiens (human) | Potency | 42.1632 | 1 | 0 |
| endosulfan | Homo sapiens (human) | Potency | 21.1317 | 1 | 0 |
| ethacrynic acid | Homo sapiens (human) | Potency | 37.5780 | 1 | 0 |
| ethoxyquin | Homo sapiens (human) | Potency | 42.1632 | 1 | 0 |
| flutamide | Homo sapiens (human) | Potency | 23.7101 | 1 | 0 |
| glutaral | Homo sapiens (human) | Potency | 33.4915 | 1 | 0 |
| heptachlor | Homo sapiens (human) | Potency | 0.7498 | 1 | 0 |
| hexachlorophene | Homo sapiens (human) | Potency | 1.0591 | 1 | 0 |
| hexylresorcinol | Homo sapiens (human) | Potency | 59.5572 | 1 | 0 |
| indole-3-carbinol | Homo sapiens (human) | Potency | 9.4392 | 1 | 0 |
| indomethacin | Homo sapiens (human) | Potency | 9.4392 | 1 | 0 |
| lauric acid | Homo sapiens (human) | Potency | 48.3368 | 1 | 0 |
| malathion | Homo sapiens (human) | Potency | 0.0531 | 1 | 0 |
| methoxsalen | Homo sapiens (human) | Potency | 13.3332 | 1 | 0 |
| methoxychlor | Homo sapiens (human) | Potency | 34.3832 | 1 | 0 |
| mitotane | Homo sapiens (human) | Potency | 33.4915 | 1 | 0 |
| nifedipine | Homo sapiens (human) | Potency | 66.8242 | 1 | 0 |
| oxybenzone | Homo sapiens (human) | Potency | 37.5780 | 1 | 0 |
| quinone | Homo sapiens (human) | Potency | 26.6032 | 1 | 0 |
| phenolphthalein | Homo sapiens (human) | Potency | 66.8242 | 1 | 0 |
| pyrilamine | Homo sapiens (human) | Potency | 0.5956 | 1 | 0 |
| pyrimethamine | Homo sapiens (human) | Potency | 29.8493 | 1 | 0 |
| resorcinol | Homo sapiens (human) | Potency | 74.9780 | 1 | 0 |
| salicylamide | Homo sapiens (human) | Potency | 84.1267 | 1 | 0 |
| thiabendazole | Homo sapiens (human) | Potency | 9.4392 | 1 | 0 |
| thiram | Homo sapiens (human) | Potency | 5.3080 | 1 | 0 |
| triacetin | Homo sapiens (human) | Potency | 1.0591 | 1 | 0 |
| octoxynol | Homo sapiens (human) | Potency | 42.1632 | 1 | 0 |
| corticosterone | Homo sapiens (human) | Potency | 23.7101 | 1 | 0 |
| reserpine | Homo sapiens (human) | Potency | 37.5780 | 1 | 0 |
| piperonyl butoxide | Homo sapiens (human) | Potency | 23.7101 | 1 | 0 |
| 2-aminophenol | Homo sapiens (human) | Potency | 37.5780 | 1 | 0 |
| prednisone | Homo sapiens (human) | Potency | 7.4978 | 1 | 0 |
| 1,2,5,6-dibenzanthracene | Homo sapiens (human) | Potency | 0.3349 | 1 | 0 |
| diethylnitrosamine | Homo sapiens (human) | Potency | 16.7855 | 1 | 0 |
| mechlorethamine hydrochloride | Homo sapiens (human) | Potency | 26.6032 | 1 | 0 |
| ethinyl estradiol | Homo sapiens (human) | Potency | 33.4915 | 1 | 0 |
| chlordan | Homo sapiens (human) | Potency | 37.5780 | 1 | 0 |
| 9,10-dimethyl-1,2-benzanthracene | Homo sapiens (human) | Potency | 13.3332 | 1 | 0 |
| methyltestosterone | Homo sapiens (human) | Potency | 16.7855 | 1 | 0 |
| 2,3,4,6-tetrachlorophenol | Homo sapiens (human) | Potency | 33.4915 | 1 | 0 |
| bromodeoxyuridine | Homo sapiens (human) | Potency | 7.4978 | 1 | 0 |
| p-dimethylaminoazobenzene | Homo sapiens (human) | Potency | 26.6032 | 1 | 0 |
| androstenedione | Homo sapiens (human) | Potency | 33.4915 | 1 | 0 |
| colchicine | Homo sapiens (human) | Potency | 0.2268 | 1 | 0 |
| cycloheximide | Homo sapiens (human) | Potency | 0.1934 | 1 | 0 |
| chloroform | Homo sapiens (human) | Potency | 74.9780 | 1 | 0 |
| hexachloroethane | Homo sapiens (human) | Potency | 6.6824 | 1 | 0 |
| dinitrofluorobenzene | Homo sapiens (human) | Potency | 33.4915 | 1 | 0 |
| medroxyprogesterone acetate | Homo sapiens (human) | Potency | 16.7855 | 1 | 0 |
| dichlorodiphenyldichloroethane | Homo sapiens (human) | Potency | 37.5780 | 1 | 0 |
| perthane | Homo sapiens (human) | Potency | 37.5780 | 1 | 0 |
| n,n'-diphenyl-4-phenylenediamine | Homo sapiens (human) | Potency | 2.3710 | 1 | 0 |
| bromoethane | Homo sapiens (human) | Potency | 133.3320 | 1 | 0 |
| bromochloromethane | Homo sapiens (human) | Potency | 74.9780 | 1 | 0 |
| vinylidene chloride | Homo sapiens (human) | Potency | 0.9439 | 1 | 0 |
| iodoform | Homo sapiens (human) | Potency | 16.7855 | 1 | 0 |
| chloropicrin | Homo sapiens (human) | Potency | 29.8493 | 1 | 0 |
| fluoxymesterone | Homo sapiens (human) | Potency | 29.8493 | 1 | 0 |
| hexachlorocyclopentadiene | Homo sapiens (human) | Potency | 13.3332 | 1 | 0 |
| triethyl phosphate | Homo sapiens (human) | Potency | 6.6824 | 1 | 0 |
| tris(2-butoxyethyl) phosphate | Homo sapiens (human) | Potency | 42.1632 | 1 | 0 |
| 1,1,2,2-tetrachloroethane | Homo sapiens (human) | Potency | 0.1883 | 1 | 0 |
| tetrabromobisphenol a | Homo sapiens (human) | Potency | 35.5348 | 1 | 0 |
| bisphenol a | Homo sapiens (human) | Potency | 38.5786 | 1 | 0 |
| 4,4'-dichlorodiphenyl sulfone | Homo sapiens (human) | Potency | 33.4915 | 1 | 0 |
| cumene hydroperoxide | Homo sapiens (human) | Potency | 42.1632 | 1 | 0 |
| alpha-pinene | Homo sapiens (human) | Potency | 42.1632 | 1 | 0 |
| 1-amino-2-methylanthraquinone | Homo sapiens (human) | Potency | 1.8834 | 1 | 0 |
| quinophthalone | Homo sapiens (human) | Potency | 11.8832 | 1 | 0 |
| pindone | Homo sapiens (human) | Potency | 21.1317 | 1 | 0 |
| musk ambrette (artificial) | Homo sapiens (human) | Potency | 0.3349 | 1 | 0 |
| benzo(f)quinoline | Homo sapiens (human) | Potency | 33.4915 | 1 | 0 |
| phthalic anhydride | Homo sapiens (human) | Potency | 1.1883 | 1 | 0 |
| carbazole | Homo sapiens (human) | Potency | 26.6032 | 1 | 0 |
| 2,4,6-trichlorophenol | Homo sapiens (human) | Potency | 29.8493 | 1 | 0 |
| 2-nitro-4-methylaniline | Homo sapiens (human) | Potency | 33.4915 | 1 | 0 |
| 2-anisidine | Homo sapiens (human) | Potency | 2.3710 | 1 | 0 |
| 1-methylnaphthalene | Homo sapiens (human) | Potency | 5.9557 | 1 | 0 |
| 2,6-diisocyanatotoluene | Homo sapiens (human) | Potency | 84.1267 | 1 | 0 |
| decalin | Homo sapiens (human) | Potency | 66.8242 | 1 | 0 |
| uvitex swn | Homo sapiens (human) | Potency | 16.7855 | 1 | 0 |
| 2-naphthylamine | Homo sapiens (human) | Potency | 2.1132 | 1 | 0 |
| 6-methylcoumarin | Homo sapiens (human) | Potency | 42.1632 | 1 | 0 |
| n,n-diethyl 4-phenylenediamine | Homo sapiens (human) | Potency | 37.5780 | 1 | 0 |
| synephrine | Homo sapiens (human) | Potency | 2.6603 | 1 | 0 |
| butylparaben | Homo sapiens (human) | Potency | 10.5909 | 1 | 0 |
| 2-dichlorobenzene | Homo sapiens (human) | Potency | 16.7855 | 1 | 0 |
| 1,2-diaminobenzene | Homo sapiens (human) | Potency | 0.1883 | 1 | 0 |
| 3,4-xylidine | Homo sapiens (human) | Potency | 37.5780 | 1 | 0 |
| 3-chloro-4-methylaniline | Homo sapiens (human) | Potency | 1.1883 | 1 | 0 |
| 3,4-dichlorophenol | Homo sapiens (human) | Potency | 21.1317 | 1 | 0 |
| 2,4-diaminotoluene | Homo sapiens (human) | Potency | 2.6603 | 1 | 0 |
| 4-chloro-1,2-diaminobenzene | Homo sapiens (human) | Potency | 0.7498 | 1 | 0 |
| 2-amino-4-methylphenol | Homo sapiens (human) | Potency | 74.9780 | 1 | 0 |
| 2,4,5-trichlorophenol | Homo sapiens (human) | Potency | 23.7101 | 1 | 0 |
| 4,4'-thiobis(6-tert-butyl-3-cresol) | Homo sapiens (human) | Potency | 4.2163 | 1 | 0 |
| 4-methyl-3-nitrobenzoic acid | Homo sapiens (human) | Potency | 11.8832 | 1 | 0 |
| 2,4-dinitroaniline | Homo sapiens (human) | Potency | 0.9439 | 1 | 0 |
| fentichlor | Homo sapiens (human) | Potency | 14.9601 | 1 | 0 |
| furaldehyde | Homo sapiens (human) | Potency | 8.4127 | 1 | 0 |
| benzenesulfonyl chloride | Homo sapiens (human) | Potency | 33.4915 | 1 | 0 |
| p-tert-butyl catechol | Homo sapiens (human) | Potency | 59.5572 | 1 | 0 |
| alpha-methylstyrol | Homo sapiens (human) | Potency | 0.5956 | 1 | 0 |
| 3-toluic acid | Homo sapiens (human) | Potency | 2.9849 | 1 | 0 |
| 3-dimethylaminophenol | Homo sapiens (human) | Potency | 29.8493 | 1 | 0 |
| dicloran | Homo sapiens (human) | Potency | 26.6032 | 1 | 0 |
| 5-nitro-2-methoxyaniline | Homo sapiens (human) | Potency | 13.3332 | 1 | 0 |
| 3-dinitrobenzene | Homo sapiens (human) | Potency | 66.8242 | 1 | 0 |
| dimethyl-4-phenylenediamine | Homo sapiens (human) | Potency | 1.1883 | 1 | 0 |
| 4-nitrotoluene | Homo sapiens (human) | Potency | 0.2660 | 1 | 0 |
| 4-nitroaniline | Homo sapiens (human) | Potency | 18.8336 | 1 | 0 |
| tetramethylphenylenediamine | Homo sapiens (human) | Potency | 2.9849 | 1 | 0 |
| methylenebis(chloroaniline) | Homo sapiens (human) | Potency | 29.8493 | 1 | 0 |
| 3-hydroxydiphenylamine | Homo sapiens (human) | Potency | 16.7855 | 1 | 0 |
| n,n,n',n'-tetramethyl-4,4'-methylenedianiline | Homo sapiens (human) | Potency | 59.5572 | 1 | 0 |
| n-isopropyl-n-phenyl-4-phenylenediamine | Homo sapiens (human) | Potency | 59.5572 | 1 | 0 |
| dicyclohexylamine | Homo sapiens (human) | Potency | 23.7101 | 1 | 0 |
| diglycidyl resorcinol ether | Homo sapiens (human) | Potency | 42.1632 | 1 | 0 |
| 1,3-diphenylurea | Homo sapiens (human) | Potency | 0.8413 | 1 | 0 |
| diethylhexyladipate | Homo sapiens (human) | Potency | 5.3080 | 1 | 0 |
| dibenzyl ether | Homo sapiens (human) | Potency | 26.6032 | 1 | 0 |
| 4-chlorobenzaldehyde | Homo sapiens (human) | Potency | 0.0531 | 1 | 0 |
| dimethyl succinate | Homo sapiens (human) | Potency | 23.7101 | 1 | 0 |
| 1,3-dimethylbutylamine | Homo sapiens (human) | Potency | 21.1317 | 1 | 0 |
| biuret | Homo sapiens (human) | Potency | 66.8242 | 1 | 0 |
| 3-xylene | Homo sapiens (human) | Potency | 7.4978 | 1 | 0 |
| 3-phenylenediamine | Homo sapiens (human) | Potency | 2.3710 | 1 | 0 |
| bis(2-chloro-1-methylethyl) ether | Homo sapiens (human) | Potency | 29.8493 | 1 | 0 |
| 1,3,5-trichlorobenzene | Homo sapiens (human) | Potency | 29.8493 | 1 | 0 |
| furan | Homo sapiens (human) | Potency | 0.9439 | 1 | 0 |
| 2,5-hexanedione | Homo sapiens (human) | Potency | 0.3758 | 1 | 0 |
| n,n'-methylenebisacrylamide | Homo sapiens (human) | Potency | 0.2660 | 1 | 0 |
| succinonitrile | Homo sapiens (human) | Potency | 47.3079 | 1 | 0 |
| heptanoic acid | Homo sapiens (human) | Potency | 3.3491 | 1 | 0 |
| ethylene glycol monoethyl ether acetate | Homo sapiens (human) | Potency | 0.9439 | 1 | 0 |
| diethanolamine | Homo sapiens (human) | Potency | 0.9439 | 1 | 0 |
| n(1)-acetylphenylhydrazine | Homo sapiens (human) | Potency | 66.8242 | 1 | 0 |
| dicofol | Homo sapiens (human) | Potency | 66.8242 | 1 | 0 |
| 2-aminoanthraquinone | Homo sapiens (human) | Potency | 1.1883 | 1 | 0 |
| diethylhexyl phthalate | Homo sapiens (human) | Potency | 74.9780 | 1 | 0 |
| homosalate | Homo sapiens (human) | Potency | 74.9780 | 1 | 0 |
| benzyl salicylate | Homo sapiens (human) | Potency | 13.3332 | 1 | 0 |
| chloranil | Homo sapiens (human) | Potency | 7.4978 | 1 | 0 |
| dianisidine | Homo sapiens (human) | Potency | 18.8336 | 1 | 0 |
| 2-tolidine | Homo sapiens (human) | Potency | 8.4127 | 1 | 0 |
| benzethonium chloride | Homo sapiens (human) | Potency | 42.1632 | 1 | 0 |
| 2-amino-5-nitrothiazole | Homo sapiens (human) | Potency | 21.1317 | 1 | 0 |
| captan | Homo sapiens (human) | Potency | 5.4494 | 1 | 0 |
| 2-Phenylethyl 2-aminobenzoate | Homo sapiens (human) | Potency | 0.2985 | 1 | 0 |
| neozone | Homo sapiens (human) | Potency | 2.9849 | 1 | 0 |
| phenazopyridine hydrochloride | Homo sapiens (human) | Potency | 1.1883 | 1 | 0 |
| 2-aminobenzothiazole | Homo sapiens (human) | Potency | 29.8493 | 1 | 0 |
| 2,4,5-trimethylaniline | Homo sapiens (human) | Potency | 42.1632 | 1 | 0 |
| ziram | Homo sapiens (human) | Potency | 8.4127 | 1 | 0 |
| 4-nitrosodimethylaniline | Homo sapiens (human) | Potency | 7.4978 | 1 | 0 |
| monuron | Homo sapiens (human) | Potency | 7.4978 | 1 | 0 |
| 4'-(chloroacetyl)acetanilide | Homo sapiens (human) | Potency | 9.4392 | 1 | 0 |
| pentamidine isethionate | Homo sapiens (human) | Potency | 18.8336 | 1 | 0 |
| sterogenol | Homo sapiens (human) | Potency | 1.1883 | 1 | 0 |
| mequinol | Homo sapiens (human) | Potency | 42.1632 | 1 | 0 |
| benzo(b)fluoranthene | Homo sapiens (human) | Potency | 4.2163 | 1 | 0 |
| benzo(k)fluoranthene | Homo sapiens (human) | Potency | 1.1883 | 1 | 0 |
| azacitidine | Homo sapiens (human) | Potency | 3.3491 | 1 | 0 |
| 2,4-difluoroaniline | Homo sapiens (human) | Potency | 10.5909 | 1 | 0 |
| 3,5-dinitro-4-chloro-alpha,alpha,alpha-trifluorotoluene | Homo sapiens (human) | Potency | 26.6032 | 1 | 0 |
| cyproterone acetate | Homo sapiens (human) | Potency | 37.5780 | 1 | 0 |
| lithocholic acid | Homo sapiens (human) | Potency | 74.9780 | 1 | 0 |
| rhein | Homo sapiens (human) | Potency | 37.5780 | 1 | 0 |
| chrysophanic acid | Homo sapiens (human) | Potency | 6.6824 | 1 | 0 |
| indigo | Homo sapiens (human) | Potency | 0.8413 | 1 | 0 |
| ninhydrin | Homo sapiens (human) | Potency | 37.5780 | 1 | 0 |
| benzohydroxamic acid | Homo sapiens (human) | Potency | 21.1317 | 1 | 0 |
| fenazox | Homo sapiens (human) | Potency | 4.7308 | 1 | 0 |
| 3,4-toluenediamine | Homo sapiens (human) | Potency | 0.1883 | 1 | 0 |
| olivetol | Homo sapiens (human) | Potency | 26.6032 | 1 | 0 |
| isophytol | Homo sapiens (human) | Potency | 66.8242 | 1 | 0 |
| dihydrotestosterone | Homo sapiens (human) | Potency | 26.6032 | 1 | 0 |
| dimenhydrinate | Homo sapiens (human) | Potency | 74.9780 | 1 | 0 |
| flavone | Homo sapiens (human) | Potency | 1.4960 | 1 | 0 |
| 2-methylbenzaldehyde | Homo sapiens (human) | Potency | 33.4915 | 1 | 0 |
| chrysoidine | Homo sapiens (human) | Potency | 0.5308 | 1 | 0 |
| 2-methylfuran | Homo sapiens (human) | Potency | 13.3332 | 1 | 0 |
| 4,6-dinitro-o-cresol | Homo sapiens (human) | Potency | 13.3332 | 1 | 0 |
| domiphen bromide | Homo sapiens (human) | Potency | 10.5909 | 1 | 0 |
| dicyclohexylcarbodiimide | Homo sapiens (human) | Potency | 18.8336 | 1 | 0 |
| 1,3-dichlorobenzene | Homo sapiens (human) | Potency | 0.3349 | 1 | 0 |
| isobutyl nitrite | Homo sapiens (human) | Potency | 33.4915 | 1 | 0 |
| gentian violet | Homo sapiens (human) | Potency | 2.3710 | 1 | 0 |
| amitriptyline hydrochloride | Homo sapiens (human) | Potency | 8.4127 | 1 | 0 |
| chlorotrianisene | Homo sapiens (human) | Potency | 18.8336 | 1 | 0 |
| 4-amino-1,2,4-triazole | Homo sapiens (human) | Potency | 53.0804 | 1 | 0 |
| toluene 2,4-diisocyanate | Homo sapiens (human) | Potency | 37.5780 | 1 | 0 |
| 3-aminophenol | Homo sapiens (human) | Potency | 5.9557 | 1 | 0 |
| allyl acetate | Homo sapiens (human) | Potency | 0.0944 | 1 | 0 |
| 2,2-dichloropropane | Homo sapiens (human) | Potency | 0.2113 | 1 | 0 |
| 2,2-dimethylbutyric acid | Homo sapiens (human) | Potency | 3.7578 | 1 | 0 |
| 2,3-dinitrotoluene | Homo sapiens (human) | Potency | 42.1632 | 1 | 0 |
| pentabromophenol | Homo sapiens (human) | Potency | 66.8242 | 1 | 0 |
| 3,4,5-trichlorophenol | Homo sapiens (human) | Potency | 13.3332 | 1 | 0 |
| 2-anthramine | Homo sapiens (human) | Potency | 6.6824 | 1 | 0 |
| methyl isocyanate | Homo sapiens (human) | Potency | 33.4915 | 1 | 0 |
| 2,4-pentanediol | Homo sapiens (human) | Potency | 33.4915 | 1 | 0 |
| ethoxyacetic acid | Homo sapiens (human) | Potency | 0.5956 | 1 | 0 |
| ethylene glycol diethyl ether | Homo sapiens (human) | Potency | 4.2163 | 1 | 0 |
| tetrabromophthalic anhydride | Homo sapiens (human) | Potency | 1.3333 | 1 | 0 |
| 1,2,3,4-tetrachlorobenzene | Homo sapiens (human) | Potency | 5.9557 | 1 | 0 |
| 1,2,3,5-tetrachlorobenzene | Homo sapiens (human) | Potency | 0.0944 | 1 | 0 |
| o,p'-ddt | Homo sapiens (human) | Potency | 84.1267 | 1 | 0 |
| n-(1,3-dimethylbutyl)-n'-phenyl-1,4-phenylenediamine | Homo sapiens (human) | Potency | 37.5780 | 1 | 0 |
| 2-hydroxyethyl acrylate | Homo sapiens (human) | Potency | 74.9780 | 1 | 0 |
| 2,6-diaminotoluene | Homo sapiens (human) | Potency | 0.0298 | 1 | 0 |
| tetrachloronitrobenzene | Homo sapiens (human) | Potency | 33.4915 | 1 | 0 |
| 2,3,5-trichlorophenol | Homo sapiens (human) | Potency | 18.8336 | 1 | 0 |
| 1,3,5-triallyl isocyanurate | Homo sapiens (human) | Potency | 18.8336 | 1 | 0 |
| phenylglyoxal | Homo sapiens (human) | Potency | 66.8242 | 1 | 0 |
| carmine | Homo sapiens (human) | Potency | 26.6032 | 1 | 0 |
| 4-chloro-2-cresol | Homo sapiens (human) | Potency | 18.8336 | 1 | 0 |
| n-(1-naphthyl)ethylenediamine dihydrochloride | Homo sapiens (human) | Potency | 42.1632 | 1 | 0 |
| 3-bromo-2,2-bis(bromomethyl)propanol | Homo sapiens (human) | Potency | 33.4915 | 1 | 0 |
| malaoxon | Homo sapiens (human) | Potency | 0.9439 | 1 | 0 |
| 2-amino-6-methoxybenzothiazole | Homo sapiens (human) | Potency | 21.1317 | 1 | 0 |
| 2-tert-butylhydroquinone | Homo sapiens (human) | Potency | 23.3174 | 1 | 0 |
| 1,6-diaminohexane | Homo sapiens (human) | Potency | 1.0591 | 1 | 0 |
| 1,5-naphthalenediamine | Homo sapiens (human) | Potency | 4.2163 | 1 | 0 |
| carvone, (s)-isomer | Homo sapiens (human) | Potency | 0.0596 | 1 | 0 |
| 1,3,5-triglycidyl-s-triazinetrione | Homo sapiens (human) | Potency | 29.8493 | 1 | 0 |
| benzophenoneidum | Homo sapiens (human) | Potency | 5.3080 | 1 | 0 |
| 4-nitrohippuric acid | Homo sapiens (human) | Potency | 2.3710 | 1 | 0 |
| dichloroacetonitrile | Homo sapiens (human) | Potency | 33.4915 | 1 | 0 |
| stavudine | Homo sapiens (human) | Potency | 0.0119 | 1 | 0 |
| cyclohexylisocyanate | Homo sapiens (human) | Potency | 13.5118 | 1 | 0 |
| pentaerythrityl triacrylate | Homo sapiens (human) | Potency | 4.2163 | 1 | 0 |
| phenoxyacetic acid | Homo sapiens (human) | Potency | 33.4915 | 1 | 0 |
| 2,2',4'-trichloroacetophenone | Homo sapiens (human) | Potency | 7.4978 | 1 | 0 |
| 2,3,4,5-tetrachlorophenate | Homo sapiens (human) | Potency | 23.7101 | 1 | 0 |
| 2,2'-dihydroxy-6,6'-dinaphthyldisulfide | Homo sapiens (human) | Potency | 33.4915 | 1 | 0 |
| octocrylene | Homo sapiens (human) | Potency | 33.4915 | 1 | 0 |
| methylene bis(thiocyanate) | Homo sapiens (human) | Potency | 37.5780 | 1 | 0 |
| c.i. acid red 114, disodium salt | Homo sapiens (human) | Potency | 42.1632 | 1 | 0 |
| ampicillin trihydrate | Homo sapiens (human) | Potency | 18.8336 | 1 | 0 |
| potassium dichromate | Homo sapiens (human) | Potency | 16.7855 | 1 | 0 |
| 1,6-hexanediol diacrylate | Homo sapiens (human) | Potency | 74.9780 | 1 | 0 |
| terbufos | Homo sapiens (human) | Potency | 26.6032 | 1 | 0 |
| N'-methyl-N,N-diphenylurea | Homo sapiens (human) | Potency | 2.6603 | 1 | 0 |
| pyrithione zinc | Homo sapiens (human) | Potency | 1.8834 | 1 | 0 |
| 2,3,4-trichlorophenol | Homo sapiens (human) | Potency | 14.9601 | 1 | 0 |
| benomyl | Homo sapiens (human) | Potency | 23.7101 | 1 | 0 |
| tetraethylene glycol diacrylate | Homo sapiens (human) | Potency | 16.5074 | 1 | 0 |
| padimate-o | Homo sapiens (human) | Potency | 84.1267 | 1 | 0 |
| 1,2-diphenylhydrazine | Homo sapiens (human) | Potency | 26.6032 | 1 | 0 |
| 4-aminoacetanilide | Homo sapiens (human) | Potency | 2.6603 | 1 | 0 |
| 2-methyl-1-nitroanthraquinone | Homo sapiens (human) | Potency | 0.6682 | 1 | 0 |
| silybin | Homo sapiens (human) | Potency | 18.8336 | 1 | 0 |
| 2-n-octyl-4-isothiazolin-3-one | Homo sapiens (human) | Potency | 11.8832 | 1 | 0 |
| sodium azide | Homo sapiens (human) | Potency | 0.0531 | 1 | 0 |
| pbde 99 | Homo sapiens (human) | Potency | 54.2348 | 1 | 0 |
| 2,4,5,2',4',5'-hexachlorobiphenyl | Homo sapiens (human) | Potency | 1.3333 | 1 | 0 |
| ribavirin | Homo sapiens (human) | Potency | 18.8336 | 1 | 0 |
| nitazoxanide | Homo sapiens (human) | Potency | 4.2163 | 1 | 0 |
| lovastatin | Homo sapiens (human) | Potency | 4.7308 | 1 | 0 |
| 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5h)-furanone | Homo sapiens (human) | Potency | 59.5572 | 1 | 0 |
| saquinavir monomethanesulfonate | Homo sapiens (human) | Potency | 59.5572 | 1 | 0 |
| daunorubicin hydrochloride | Homo sapiens (human) | Potency | 18.8336 | 1 | 0 |
| nelfinavir mesylate | Homo sapiens (human) | Potency | 8.4127 | 1 | 0 |
| 6-azacytidine | Homo sapiens (human) | Potency | 5.3080 | 1 | 0 |
| divinyl benzene | Homo sapiens (human) | Potency | 0.2371 | 1 | 0 |
| Diphenolic acid | Homo sapiens (human) | Potency | 33.4915 | 1 | 0 |
| econazole nitrate | Homo sapiens (human) | Potency | 66.8242 | 1 | 0 |
| 5-hydroxymethyl-2-furoic acid | Homo sapiens (human) | Potency | 74.9780 | 1 | 0 |
| tebuconazole | Homo sapiens (human) | Potency | 33.4915 | 1 | 0 |
| nicotine | Homo sapiens (human) | Potency | 33.4915 | 1 | 0 |
| hydroxyflutamide | Homo sapiens (human) | Potency | 18.8336 | 1 | 0 |
| 2,2',4,4'-tetrabromodiphenyl ether | Homo sapiens (human) | Potency | 11.8832 | 1 | 0 |
| bromodichloroacetic acid | Homo sapiens (human) | Potency | 8.4127 | 1 | 0 |
| 2,2',4,4',5,5'-hexabrominated diphenyl ether | Homo sapiens (human) | Potency | 42.1632 | 1 | 0 |
| lilial | Homo sapiens (human) | Potency | 94.3918 | 1 | 0 |
| (+-)-Dihydromethysticin | Homo sapiens (human) | Potency | 6.6824 | 1 | 0 |
| 5-hydroxymethylfurfural | Homo sapiens (human) | Potency | 33.4915 | 1 | 0 |
| hematoxylin | Homo sapiens (human) | Potency | 11.8832 | 1 | 0 |
| methylmercuric chloride | Homo sapiens (human) | Potency | 6.6824 | 1 | 0 |
| 5-hydroxytryptophan | Homo sapiens (human) | Potency | 33.4915 | 1 | 0 |
| griseofulvin | Homo sapiens (human) | Potency | 1.1883 | 1 | 0 |
| doxorubicin hydrochloride | Homo sapiens (human) | Potency | 1.0591 | 1 | 0 |
| resveratrol | Homo sapiens (human) | Potency | 2.3710 | 1 | 0 |
| retinol | Homo sapiens (human) | Potency | 47.3079 | 1 | 0 |
| oleic acid | Homo sapiens (human) | Potency | 37.5780 | 1 | 0 |
| zithromax | Homo sapiens (human) | Potency | 33.4915 | 1 | 0 |
| diethylstilbestrol | Homo sapiens (human) | Potency | 33.4915 | 1 | 0 |
| dactinomycin | Homo sapiens (human) | Potency | 0.0266 | 1 | 0 |
| melphalan | Homo sapiens (human) | Potency | 26.6032 | 1 | 0 |
| bromochloroacetic acid | Homo sapiens (human) | Potency | 29.8493 | 1 | 0 |
| cinnamaldehyde | Homo sapiens (human) | Potency | 37.5780 | 1 | 0 |
| 2,4-hexadienal | Homo sapiens (human) | Potency | 33.4915 | 1 | 0 |
| isosafrole | Homo sapiens (human) | Potency | 1.0591 | 1 | 0 |
| fumaronitrile | Homo sapiens (human) | Potency | 23.7101 | 1 | 0 |
| retinaldehyde | Homo sapiens (human) | Potency | 29.8493 | 1 | 0 |
| phenylthiourea | Homo sapiens (human) | Potency | 4.3080 | 1 | 0 |
| diphenylthiourea | Homo sapiens (human) | Potency | 21.1317 | 1 | 0 |
| 2-mercaptobenzimidazole | Homo sapiens (human) | Potency | 33.4915 | 1 | 0 |
| curcumin | Homo sapiens (human) | Potency | 33.4915 | 1 | 0 |
| capsaicin | Homo sapiens (human) | Potency | 33.4915 | 1 | 0 |
| ethylenethiourea | Homo sapiens (human) | Potency | 0.1496 | 1 | 0 |
| thiosemicarbazide | Homo sapiens (human) | Potency | 23.7101 | 1 | 0 |
| thiourea | Homo sapiens (human) | Potency | 74.9780 | 1 | 0 |
| digoxin | Homo sapiens (human) | Potency | 9.4392 | 1 | 0 |
| malachite green | Homo sapiens (human) | Potency | 0.1883 | 1 | 0 |
| tamoxifen citrate | Homo sapiens (human) | Potency | 29.8493 | 1 | 0 |
| tetraoctylammonium bromide | Homo sapiens (human) | Potency | 1.4960 | 1 | 0 |
| ethionamide | Homo sapiens (human) | Potency | 1.1883 | 1 | 0 |
| zeranol | Homo sapiens (human) | Potency | 42.1632 | 1 | 0 |
| thiophanate | Homo sapiens (human) | Potency | 8.4127 | 1 | 0 |
| 1,8-dinitro-4,5-dihydroxyanthraquinone | Homo sapiens (human) | Potency | 16.7855 | 1 | 0 |
| 4-amino-2-nitrophenol | Homo sapiens (human) | Potency | 74.9780 | 1 | 0 |
| 2-amino-4-nitrophenol | Homo sapiens (human) | Potency | 23.7101 | 1 | 0 |
| methyl ethyl ketone peroxide | Homo sapiens (human) | Potency | 29.8493 | 1 | 0 |
| 2-nitro-4-phenylenediamine | Homo sapiens (human) | Potency | 5.9557 | 1 | 0 |
| 1,2-diamino-4-nitrobenzene | Homo sapiens (human) | Potency | 42.1632 | 1 | 0 |
| 5,6-dehydrokawain | Homo sapiens (human) | Potency | 1.4960 | 1 | 0 |
| apigenin | Homo sapiens (human) | Potency | 4.2163 | 1 | 0 |
| cholecalciferol | Homo sapiens (human) | Potency | 37.5780 | 1 | 0 |
| kaempferol | Homo sapiens (human) | Potency | 74.9780 | 1 | 0 |
| amphotericin b | Homo sapiens (human) | Potency | 74.9780 | 1 | 0 |
| oxymetholone | Homo sapiens (human) | Potency | 33.4915 | 1 | 0 |
| norbixin | Homo sapiens (human) | Potency | 1.3333 | 1 | 0 |
| kavain | Homo sapiens (human) | Potency | 33.4915 | 1 | 0 |
| methysticin | Homo sapiens (human) | Potency | 0.0841 | 1 | 0 |
| yangonin | Homo sapiens (human) | Potency | 1.8834 | 1 | 0 |
| zearalenone | Homo sapiens (human) | Potency | 58.5706 | 1 | 0 |
| daidzein | Homo sapiens (human) | Potency | 1.1883 | 1 | 0 |
| chicoric acid | Homo sapiens (human) | Potency | 3.3491 | 1 | 0 |
| 2,4-decadienal | Homo sapiens (human) | Potency | 33.4915 | 1 | 0 |
| phenoxybenzamine hydrochloride | Homo sapiens (human) | Potency | 42.1632 | 1 | 0 |
| tetrachlorvinphos | Homo sapiens (human) | Potency | 59.5572 | 1 | 0 |
| toxaphene | Homo sapiens (human) | Potency | 59.5572 | 1 | 0 |
| afimoxifene | Homo sapiens (human) | Potency | 33.4915 | 1 | 0 |
| fenretinide | Homo sapiens (human) | Potency | 26.6032 | 1 | 0 |
| 2-pentenenitrile | Homo sapiens (human) | Potency | 37.5780 | 1 | 0 |
| methoprene | Homo sapiens (human) | Potency | 2.3710 | 1 | 0 |
| nitrofurazone | Homo sapiens (human) | Potency | 42.1632 | 1 | 0 |
| 13-cis-retinal | Homo sapiens (human) | Potency | 21.1317 | 1 | 0 |
| pregna-4,17-diene-3,16-dione | Homo sapiens (human) | Potency | 47.3079 | 1 | 0 |
| valerenic acid | Homo sapiens (human) | Potency | 37.5780 | 1 | 0 |
| pregna-4,17-diene-3,16-dione, (17z)-isomer | Homo sapiens (human) | Potency | 33.4915 | 1 | 0 |
| nitrofurantoin | Homo sapiens (human) | Potency | 37.5780 | 1 | 0 |
| chlorhexidine | Homo sapiens (human) | Potency | 26.6032 | 1 | 0 |
| aldicarb | Homo sapiens (human) | Potency | 1.1883 | 1 | 0 |
| phenylmercuric acetate | Homo sapiens (human) | Potency | 0.5308 | 1 | 0 |
| sodium hypochlorite | Homo sapiens (human) | Potency | 2.3710 | 1 | 0 |
| sodium nitrite | Homo sapiens (human) | Potency | 47.3079 | 1 | 0 |
| sodium bromate | Homo sapiens (human) | Potency | 54.2348 | 1 | 0 |
| deoxycholic acid, monosodium salt | Homo sapiens (human) | Potency | 42.1632 | 1 | 0 |
| dexon (fungicide), sodium salt | Homo sapiens (human) | Potency | 5.9557 | 1 | 0 |
| oxytetracycline hydrochloride | Homo sapiens (human) | Potency | 6.6824 | 1 | 0 |
| methylnitronitrosoguanidine | Homo sapiens (human) | Potency | 37.5780 | 1 | 0 |
Drugs with Inhibition Measurements
Drugs with Activation Measurements
Retinoic Acid Receptor-Related Orphan Receptor γt (RORγt) Agonists as Potential Small Molecule Therapeutics for Cancer Immunotherapy.Journal of medicinal chemistry, , Jul-26, Volume: 61, Issue:14, 2018
Recent progress on nuclear receptor RORγ modulators.Bioorganic & medicinal chemistry letters, , 09-15, Volume: 26, Issue:18, 2016
A reversed sulfonamide series of selective RORc inverse agonists.Bioorganic & medicinal chemistry letters, , Dec-15, Volume: 24, Issue:24, 2014
Retinoic Acid Receptor-Related Orphan Receptor γt (RORγt) Agonists as Potential Small Molecule Therapeutics for Cancer Immunotherapy.Journal of medicinal chemistry, , Jul-26, Volume: 61, Issue:14, 2018
A reversed sulfonamide series of selective RORc inverse agonists.Bioorganic & medicinal chemistry letters, , Dec-15, Volume: 24, Issue:24, 2014
Covalent Occlusion of the RORγt Ligand Binding Pocket Allows Unambiguous Targeting of an Allosteric Site.ACS medicinal chemistry letters, , Apr-08, Volume: 12, Issue:4, 2021
Retinoic Acid Receptor-Related Orphan Receptor γt (RORγt) Agonists as Potential Small Molecule Therapeutics for Cancer Immunotherapy.Journal of medicinal chemistry, , Jul-26, Volume: 61, Issue:14, 2018
Modulators of the nuclear receptor retinoic acid receptor-related orphan receptor-γ (RORγ or RORc).Journal of medicinal chemistry, , Jul-24, Volume: 57, Issue:14, 2014
Identification of the first inverse agonist of retinoid-related orphan receptor (ROR) with dual selectivity for RORβ and RORγt.Bioorganic & medicinal chemistry letters, , Nov-15, Volume: 24, Issue:22, 2014
[no title available]Journal of medicinal chemistry, , 01-13, Volume: 65, Issue:1, 2022
Discovery and Characterization of XY101, a Potent, Selective, and Orally Bioavailable RORγ Inverse Agonist for Treatment of Castration-Resistant Prostate Cancer.Journal of medicinal chemistry, , 05-09, Volume: 62, Issue:9, 2019
Development of novel silanol-based human pregnane X receptor (PXR) agonists with improved receptor selectivity.Bioorganic & medicinal chemistry, , 08-15, Volume: 26, Issue:15, 2018
Identification of bicyclic hexafluoroisopropyl alcohol sulfonamides as retinoic acid receptor-related orphan receptor gamma (RORγ/RORc) inverse agonists. Employing structure-based drug design to improve pregnane X receptor (PXR) selectivity.Bioorganic & medicinal chemistry letters, , 01-15, Volume: 28, Issue:2, 2018
Altered activity profile of a tertiary silanol analog of multi-targeting nuclear receptor modulator T0901317.Bioorganic & medicinal chemistry letters, , Apr-01, Volume: 26, Issue:7, 2016
Discovery of biaryls as RORγ inverse agonists by using structure-based design.Bioorganic & medicinal chemistry letters, , 05-15, Volume: 26, Issue:10, 2016
Structure-activity relationship-guided development of retinoic acid receptor-related orphan receptor gamma (RORγ)-selective inverse agonists with a phenanthridin-6(5H)-one skeleton from a liver X receptor ligand.Bioorganic & medicinal chemistry, , May-01, Volume: 22, Issue:9, 2014
Modulators of the nuclear receptor retinoic acid receptor-related orphan receptor-γ (RORγ or RORc).Journal of medicinal chemistry, , Jul-24, Volume: 57, Issue:14, 2014
Discovery of 2-oxo-1,2-dihydrobenzo[cd]indole-6-sulfonamide derivatives as new RORγ inhibitors using virtual screening, synthesis and biological evaluation.European journal of medicinal chemistry, , May-06, Volume: 78, 2014
Identification of the first inverse agonist of retinoid-related orphan receptor (ROR) with dual selectivity for RORβ and RORγt.Bioorganic & medicinal chemistry letters, , Nov-15, Volume: 24, Issue:22, 2014
Structure-based design of substituted hexafluoroisopropanol-arylsulfonamides as modulators of RORc.Bioorganic & medicinal chemistry letters, , Dec-15, Volume: 23, Issue:24, 2013
Covalent Occlusion of the RORγt Ligand Binding Pocket Allows Unambiguous Targeting of an Allosteric Site.ACS medicinal chemistry letters, , Apr-08, Volume: 12, Issue:4, 2021
Ligand-Based Design of Allosteric Retinoic Acid Receptor-Related Orphan Receptor γt (RORγt) Inverse Agonists.Journal of medicinal chemistry, , 01-09, Volume: 63, Issue:1, 2020
A reversed sulfonamide series of selective RORc inverse agonists.Bioorganic & medicinal chemistry letters, , Dec-15, Volume: 24, Issue:24, 2014
Modulators of the nuclear receptor retinoic acid receptor-related orphan receptor-γ (RORγ or RORc).Journal of medicinal chemistry, , Jul-24, Volume: 57, Issue:14, 2014
Identification of Potent and Selective Diphenylpropanamide RORγ Inhibitors.ACS medicinal chemistry letters, , Jan-10, Volume: 4, Issue:1, 2013
[no title available],
Modulators of the nuclear receptor retinoic acid receptor-related orphan receptor-γ (RORγ or RORc).Journal of medicinal chemistry, , Jul-24, Volume: 57, Issue:14, 2014
Structure-based design of substituted hexafluoroisopropanol-arylsulfonamides as modulators of RORc.Bioorganic & medicinal chemistry letters, , Dec-15, Volume: 23, Issue:24, 2013
Identification of N-phenyl-2-(N-phenylphenylsulfonamido)acetamides as new RORγ inverse agonists: Virtual screening, structure-based optimization, and biological evaluation.European journal of medicinal chemistry, , Jun-30, Volume: 116, 2016
Modulators of the nuclear receptor retinoic acid receptor-related orphan receptor-γ (RORγ or RORc).Journal of medicinal chemistry, , Jul-24, Volume: 57, Issue:14, 2014
Discovery of 2-oxo-1,2-dihydrobenzo[cd]indole-6-sulfonamide derivatives as new RORγ inhibitors using virtual screening, synthesis and biological evaluation.European journal of medicinal chemistry, , May-06, Volume: 78, 2014
Enables
This protein enables 10 target(s):
| Target | Category | Definition |
|---|
| RNA polymerase II cis-regulatory region sequence-specific DNA binding | molecular function | Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II. [GOC:txnOH-2018] |
| DNA-binding transcription factor activity, RNA polymerase II-specific | molecular function | A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II. [GOC:txnOH-2018] |
| DNA-binding transcription repressor activity, RNA polymerase II-specific | molecular function | A DNA-binding transcription factor activity that represses or decreases the transcription of specific gene sets transcribed by RNA polymerase II. [GOC:txnOH-2018] |
| DNA-binding transcription factor activity | molecular function | A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. [GOC:txnOH-2018] |
| protein binding | molecular function | Binding to a protein. [GOC:go_curators] |
| oxysterol binding | molecular function | Binding to oxysterol, an oxidized form of cholesterol. [GOC:curators] |
| zinc ion binding | molecular function | Binding to a zinc ion (Zn). [GOC:ai] |
| ligand-activated transcription factor activity | molecular function | A DNA-binding transcription factor activity regulated by binding to a ligand and that modulates the transcription of specific genes and gene sets. Examples include the lac and trp repressors in E.coli and steroid hormone receptors. [GOC:dos, PMID:25568920, PMID:8735275] |
| sequence-specific double-stranded DNA binding | molecular function | Binding to double-stranded DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA, e.g. promotor binding or rDNA binding. [GOC:dos, GOC:sl] |
| nuclear receptor activity | molecular function | A DNA-binding transcription factor activity regulated by binding to a ligand that modulates the transcription of specific gene sets transcribed by RNA polymerase II. Nuclear receptor ligands are usually lipid-based (such as a steroid hormone) and the binding of the ligand to its receptor often occurs in the cytosol, which leads to its translocation to the nucleus. [GOC:txnOH-2018, PMID:23457262] |
Located In
This protein is located in 3 target(s):
| Target | Category | Definition |
|---|
| nucleus | cellular component | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators] |
| nucleoplasm | cellular component | That part of the nuclear content other than the chromosomes or the nucleolus. [GOC:ma, ISBN:0124325653] |
| nuclear body | cellular component | Extra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins. [GOC:ma, PMID:10330182] |
Active In
This protein is active in 1 target(s):
| Target | Category | Definition |
|---|
| nucleus | cellular component | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators] |
Part Of
This protein is part of 1 target(s):
| Target | Category | Definition |
|---|
| chromatin | cellular component | The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome. [GOC:elh, PMID:20404130] |
Involved In
This protein is involved in 13 target(s):
| Target | Category | Definition |
|---|
| negative regulation of transcription by RNA polymerase II | biological process | Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II. [GOC:go_curators, GOC:txnOH] |
| xenobiotic metabolic process | biological process | The chemical reactions and pathways involving a xenobiotic compound, a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical. [GOC:cab2, GOC:krc] |
| regulation of glucose metabolic process | biological process | Any process that modulates the rate, frequency or extent of glucose metabolism. Glucose metabolic processes are the chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. [GOC:BHF, GOC:tb] |
| regulation of steroid metabolic process | biological process | Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving steroids. [GOC:go_curators] |
| intracellular receptor signaling pathway | biological process | The series of molecular signals initiated by a ligand binding to a receptor located within a cell. [GOC:bf, GOC:mah] |
| circadian regulation of gene expression | biological process | Any process that modulates the frequency, rate or extent of gene expression such that an expression pattern recurs with a regularity of approximately 24 hours. [GOC:mah] |
| cellular response to sterol | biological process | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a sterol stimulus. [GOC:bf] |
| positive regulation of circadian rhythm | biological process | Any process that activates or increases the frequency, rate or extent of a circadian rhythm behavior. [GOC:go_curators] |
| regulation of fat cell differentiation | biological process | Any process that modulates the frequency, rate or extent of adipocyte differentiation. [GOC:go_curators] |
| positive regulation of DNA-templated transcription | biological process | Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription. [GOC:go_curators, GOC:txnOH] |
| adipose tissue development | biological process | The process whose specific outcome is the progression of adipose tissue over time, from its formation to the mature structure. Adipose tissue is specialized tissue that is used to store fat. [GOC:dph] |
| T-helper 17 cell differentiation | biological process | The process in which a relatively unspecialized T cell acquires the specialized features of a T-helper 17 (Th17) cell. A Th17 cell is a CD4-positive, alpha-beta T cell with the phenotype RORgamma-t-positive that produces IL-17. [CL:0000899, GOC:BHF, GOC:ebc] |
| regulation of transcription by RNA polymerase II | biological process | Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II. [GOC:go_curators, GOC:txnOH] |