Page last updated: 2024-09-23

triazoles

Description

Triazoles: Heterocyclic compounds containing a five-membered ring with two carbon atoms and three nitrogen atoms with the molecular formula C2H3N3. [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

triazoles : An azole in which the five-membered heterocyclic aromatic skeleton contains three N atoms and two C atoms. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Cross-References

ID SourceID
PubMed CID67516
CHEMBL ID2148102
CHEBI ID35565
CHEBI ID35566
MeSH IDM0021911

Synonyms (62)

Synonym
EN300-27201
1,2,3-triazole
v-triazole
1h-1,2,3-triazole
CHEBI:35565 ,
288-35-7
288-36-8
osotriazole
CHEBI:35566
1,2,3-1h-triazole
inchi=1/c2h3n3/c1-2-4-5-3-1/h1-2h,(h,3,4,5
2h-1,2,3-triazole
1h-1,2,3-triazole, 97%
triazoles
triazol
2h-triazole
T1880
A25412
1h-[1,2,3]triazole
[1,2,3]triazole
unii-em7554254w
em7554254w ,
CHEMBL2148102
1,2,3-triazol
A818904
27070-49-1
AKOS005207098
FT-0601191
AM20090377
AB01140
SY005819
mfcd00014490
triazacyclopentadiene
1h-1,2,3-triazol
1h-(1,2,3)-triazole
1-h-1,2,3-triazole
1h-[1,2,3]-triazole
2h-1, 2, 3-triazole
2h-(1,2,3)-triazole
1,2,3 triazole
2h-[1,2,3]triazole
1h-1,2,3 triazole
racemic triazole
1h1,2,3-triazole
1-h-1, 2, 3-triazole
STR09959
F1905-7135
PS-9378
J-509548
D70752
CS-B1285
BBL103173
2,3-diazapyrrole
STL556983
BCP18903
DTXSID30870495
Q161297
HUH ,
1~{h}-1,2,3-triazole
mfcd00962232
FT-0774760
Z237528494

Research Excerpts

Overview

ExcerptReference
"Triazoles are a major group of azole fungicides commonly used in agriculture, and veterinary and human medicine. "( Bhattacharya, B; Bondesson, M; Flores, S; Gustafsson, JÅ; Mesmar, F; Muhsen, M; Mukhopadhyay, S; Thrikawala, S; Upadhyay, S; Vergara, L; Williams, C, 2023)
"Triazoles are a class of aza-heterocycles with broad spectrum of biological importance. "( Darkwa, J; Makhubela, BCE; Meyer, D; Rono, CK, 2019)

Effects

ExcerptReference
"The triazoles presence has substantially affected the bioavailability of Fe, Cu and Zn in soil."( Ćavar Zeljković, S; Jakl, M; Jaklová Dytrtová, J; Kovač, I, 2021)
"Triazoles have been shown to be the most effective fungicide for managing Fusarium spp., but little is known about their specific activity on F."( Hellin, P; Legrève, A; Munaut, F; Scauflaire, J; Van Hese, V, 2017)
"The triazoles have been studied for over a century as an important class of heterocyclic compounds and still attract considerable attention due to their broad range of biological activities. "( Boechat, NA; da Rocha, DR; da Silva, FC; Ferreira, PG; Ferreira, VF; Magalhães, JL, 2013)

Drug Classes (1)

ClassDescription
1,2,3-triazole
1,2,3-triazole
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (3)

Assay IDTitleYearJournalArticle
AID701844Dissociation constant, pKa of the compound2012Journal of medicinal chemistry, Jul-12, Volume: 55, Issue:13
Mitigating heterocycle metabolism in drug discovery.
AID687184Dissociation constant, pKa of the compound at pH 2 to 3 by spectrophotometric analysis2012Journal of medicinal chemistry, Jun-14, Volume: 55, Issue:11
Rational design of 4-aryl-1,2,3-triazoles for indoleamine 2,3-dioxygenase 1 inhibition.
AID687185Dissociation constant, pKa of the compound at pH 11 to 12 by spectrophotometric analysis2012Journal of medicinal chemistry, Jun-14, Volume: 55, Issue:11
Rational design of 4-aryl-1,2,3-triazoles for indoleamine 2,3-dioxygenase 1 inhibition.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (24,888)

TimeframeStudies, This Drug (%)All Drugs %
pre-19901657 (6.66)18.7374
1990's2146 (8.62)18.2507
2000's6407 (25.74)29.6817
2010's11834 (47.55)24.3611
2020's2844 (11.43)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials2,252 (8.73%)5.53%
Reviews2,179 (8.44%)6.00%
Case Studies1,989 (7.71%)4.05%
Observational81 (0.31%)0.25%
Other19,307 (74.81%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research Highlights

Safety/Toxicity (825)

ArticleYear
Synthesis, characterization, in vitro antimycobacterial and cytotoxicity evaluation, DFT calculations, molecular docking and ADME studies of new isomeric benzimidazole-1,2,3-triazole-quinoline hybrid mixtures.
Bioorganic chemistry, Volume: 141
2023
Integrated safety analysis of filgotinib for ulcerative colitis: Results from SELECTION and SELECTIONLTE.
Alimentary pharmacology & therapeutics, Volume: 58, Issue: 9
2023
Comprehensive evaluation of chiral sedaxane with four stereoisomers for risk reduction: Bioactivity, toxicity, and stereoselective dissipation in crop planting systems.
Food chemistry, Feb-15, Volume: 434
2024
Rational understanding of chiral fungicide penthiopyrad stereoselectivity: Bioactivity, aquatic toxicity and cytotoxicity.
The Science of the total environment, Dec-20, Volume: 905
2023
Comparing efficacy and safety of stair step protocols for clomiphene citrate and letrozole in ovulation induction for women with polycystic ovary syndrome (PCOS): a randomized controlled clinical trial.
Journal of medicine and life, Volume: 16, Issue: 5
2023
New insights into triazole fungicide-caused hematopoietic abnormality in zebrafish based on GRα screening developmental toxicity.
Environmental pollution (Barking, Essex : 1987), Oct-01, Volume: 334
2023
A systematic review and meta-analysis of efficacy and safety of isavuconazole for the treatment and prophylaxis of invasive fungal infections.
Mycoses, Volume: 66, Issue: 9
2023
Assessing the safety profile of voriconazole use in suspected COVID-19-associated pulmonary aspergillosis-a two-centre observational study.
Medical mycology, Jun-05, Volume: 61, Issue: 6
2023
Modifications of geldanamycin via CuAAC altering affinity to chaperone protein Hsp90 and cytotoxicity.
European journal of medicinal chemistry, Aug-05, Volume: 256
2023
Design, Synthesis and Cytotoxicity of New Coumarin-1,2,3-triazole Derivatives: Evaluation of Anticancer Activity and Molecular Docking Studies.
Chemistry & biodiversity, Volume: 20, Issue: 7
2023
Post-hoc analysis of the safety and efficacy of isavuconazole in older patients with invasive fungal disease from the VITAL and SECURE studies.
Scientific reports, 04-25, Volume: 13, Issue: 1
2023
Resveratrol ameliorates penconazole-induced cardiotoxicity by inhibition of oxidative stress and apoptosis in zebrafish larvae.
Ecotoxicology and environmental safety, Volume: 256
2023
Population Pharmacokinetics, Exposure-Safety, and Probability of Target Attainment Analyses for Isavuconazole in Japanese Patients With Deep-Seated Mycoses.
Journal of clinical pharmacology, Volume: 63, Issue: 6
2023
Triadimenol promotes the production of reactive oxygen species and apoptosis with cardiotoxicity and developmental abnormalities in zebrafish.
The Science of the total environment, Mar-01, Volume: 862
2023
Joint toxic effects of thiamethoxam and flusilazole on the adult worker honey bees (Apis mellifera L.).
Environmental pollution (Barking, Essex : 1987), Jan-15, Volume: 317
2023
Isavuconazole for the Treatment of Invasive Mold Disease in Solid Organ Transplant Recipients: A Multicenter Study on Efficacy and Safety in Real-life Clinical Practice.
Transplantation, 03-01, Volume: 107, Issue: 3
2023
Efficacy and safety of isavuconazole against deep-seated mycoses: A phase 3, randomized, open-label study in Japan.
Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy, Volume: 29, Issue: 2
2023
Glycoconjugation of Quinoline Derivatives Using the C-6 Position in Sugars as a Strategy for Improving the Selectivity and Cytotoxicity of Functionalized Compounds.
Molecules (Basel, Switzerland), Oct-15, Volume: 27, Issue: 20
2022
Letrozole: Pharmacology, toxicity and potential therapeutic effects.
Life sciences, Dec-01, Volume: 310
2022
Difenoconazole disrupts the blood-brain barrier and results in neurotoxicity in carp by inhibiting the Nrf2 pathway mediated ROS accumulation.
Ecotoxicology and environmental safety, Oct-01, Volume: 244
2022
Voriconazole-induced severe skin allergy and neurological adverse event in a liver failure patient: A case report.
Journal of clinical pharmacy and therapeutics, Volume: 47, Issue: 10
2022
Bromuconazole exposure induces cardiotoxicity and lipid transport disorder in larval zebrafish.
Comparative biochemistry and physiology. Toxicology & pharmacology : CBP, Volume: 262
2022
Evaluation of titanium and silicon role in mitigation of fungicides toxicity in wheat expressed at the level of biochemical and antioxidant profile.
Chemosphere, Volume: 308, Issue: Pt 1
2022
Brief Report: Efficacy and Safety of Oral Islatravir Once Daily in Combination With Doravirine Through 96 Weeks for Treatment-Naive Adults With HIV-1 Infection Receiving Initial Treatment With Islatravir, Doravirine, and Lamivudine.
Journal of acquired immune deficiency syndromes (1999), 09-01, Volume: 91, Issue: 1
2022
Safe administration and pharmacokinetic monitoring of crushed venetoclax tablets with posaconazole and clarithromycin via percutaneous endoscopic gastrostomy tube in a patient with acute myeloid leukemia.
Cancer chemotherapy and pharmacology, Volume: 90, Issue: 3
2022
Synthesis of ribavirin 1,2,3- and 1,2,4-triazolyl analogs with changes at the amide and cytotoxicity in breast cancer cell lines.
Nucleosides, nucleotides & nucleic acids, Volume: 42, Issue: 1
2023
Sub-structure-based category formation for the prioritisation of genotoxicity hazard assessment for pesticide residues (part 2): Triazoles.
Regulatory toxicology and pharmacology : RTP, Volume: 134
2022
Mechanisms, toxicity and optimal conditions - research on the removal of benzotriazoles from water using Wolffia arrhiza.
The Science of the total environment, Nov-15, Volume: 847
2022
Toxicity prediction of 1,2,4-triazoles compounds by QSTR and interspecies QSTTR models.
Ecotoxicology and environmental safety, Sep-01, Volume: 242
2022
Difenoconazole causes cardiotoxicity in common carp (Cyprinus carpio): Involvement of oxidative stress, inflammation, apoptosis and autophagy.
Chemosphere, Volume: 306
2022
Torsade de Pointes/QT Prolongation Associated with Antifungal Triazoles: A Pharmacovigilance Study Based on the U.S. FDA Adverse Event Reporting System(FAERS).
Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques, Volume: 25
2022
Enantioselective neurotoxicity and oxidative stress effects of paclobutrazol in zebrafish (Danio rerio).
Pesticide biochemistry and physiology, Volume: 185
2022
Stereoselective bioactivity, toxicity and degradation of novel fungicide sedaxane with four enantiomers under rice-wheat rotation mode.
Ecotoxicology and environmental safety, Volume: 241
2022
Low trifloxystrobin-tebuconazole concentrations induce cardiac and developmental toxicity in zebrafish by regulating notch mediated-oxidative stress generation.
Ecotoxicology and environmental safety, Volume: 241
2022
Effectiveness and safety of isavuconazole prophylaxis for invasive fungal infections in the haematologic setting.
Hematology (Amsterdam, Netherlands), Volume: 27, Issue: 1
2022
Acute toxicity and antitumor potential of 1,3,4-trisubstituted-1,2,3-triazole dhmtAc-loaded liposomes on a triple-negative breast cancer model.
Archiv der Pharmazie, Volume: 355, Issue: 9
2022
Selinexor Combined with Ibrutinib Demonstrates Tolerability and Safety in Advanced B-Cell Malignancies: A Phase I Study.
Clinical cancer research : an official journal of the American Association for Cancer Research, 08-02, Volume: 28, Issue: 15
2022
Exposure to difenoconazole induces reproductive toxicity in zebrafish by interfering with gamete maturation and reproductive behavior.
The Science of the total environment, Sep-10, Volume: 838, Issue: Pt 1
2022
New Triazolyl N^N Bidentate Rh(III), Ir(III), Ru(II) and Os(II) Complexes: Synthesis and Characterization, Probing Possible Relations between Cytotoxicity with Transfer Hydrogenation Efficacy and Interaction with Model Biomolecules.
Molecules (Basel, Switzerland), Mar-23, Volume: 27, Issue: 7
2022
Network Pharmacology Combined with Metabolomics Approach to Investigate the Toxicity Mechanism of Paclobutrazol.
Chemical research in toxicology, 04-18, Volume: 35, Issue: 4
2022
Toxicity, bioactivity of triazole fungicide metconazole and its effect on mycotoxin production by Fusarium verticillioides: New perspective from an enantiomeric level.
The Science of the total environment, Jul-01, Volume: 828
2022
Hepatic safety of the antifungal triazole agent posaconazole: characterization of adverse event reports in a manufacturer's safety database.
Expert opinion on drug safety, Volume: 21, Issue: 8
2022
Developmental toxicity of fenbuconazole in zebrafish: Effects on mitochondrial respiration and locomotor behavior.
Toxicology, 03-30, Volume: 470
2022
Pharmacokinetics, Safety, and Tolerability of Single and Multiple Doses of Isavuconazonium Sulfate in Healthy Adult Japanese Subjects.
Clinical pharmacology in drug development, Volume: 11, Issue: 6
2022
Safety and Effectiveness of Isavuconazole Treatment for Fungal Infections in Solid Organ Transplant Recipients (ISASOT Study).
Microbiology spectrum, 02-23, Volume: 10, Issue: 1
2022
Synthesis, in vitro cytotoxicity, molecular docking and ADME study of some indolin-2-one linked 1,2,3-triazole derivatives.
Computational biology and chemistry, Volume: 97
2022
Efficacy and safety of balovaptan for socialisation and communication difficulties in autistic adults in North America and Europe: a phase 3, randomised, placebo-controlled trial.
The lancet. Psychiatry, Volume: 9, Issue: 3
2022
Risk Assessment of the Chiral Fungicide Triticonazole: Enantioselective Effects, Toxicity, and Fate.
Journal of agricultural and food chemistry, Mar-02, Volume: 70, Issue: 8
2022
Enantioselective acute toxicity, oxidative stress effects, neurotoxicity, and thyroid disruption of uniconazole in zebrafish (Danio rerio).
Environmental science and pollution research international, Volume: 29, Issue: 26
2022
Efficacy and safety of Isavuconazole for the treatment of invasive
Expert opinion on pharmacotherapy, Volume: 23, Issue: 5
2022
Effect of Prior Therapy and Disease Refractoriness on the Efficacy and Safety of Oral Selinexor in Patients with Diffuse Large B-cell Lymphoma (DLBCL): A Post-hoc Analysis of the SADAL Study.
Clinical lymphoma, myeloma & leukemia, Volume: 22, Issue: 7
2022
Exposure-response relationships for the efficacy and safety of filgotinib and its metabolite GS-829845 in subjects with rheumatoid arthritis based on phase 2 and phase 3 studies.
British journal of clinical pharmacology, Volume: 88, Issue: 7
2022
Novel Coumarin Derivatives Containing a Triazole Moiety: A Study on Synthesis, Cytotoxicity, Membrane Dysfunction, Apoptosis, Cell Cycle, and Antiangiogenic Effects.
Anti-cancer agents in medicinal chemistry, Volume: 22, Issue: 13
2022
Efficacy and safety of filgotinib alone and in combination with methotrexate in Japanese patients with active rheumatoid arthritis and limited or no prior exposure to methotrexate: Subpopulation analyses of 24-week data of a global phase 3 study (FINCH 3)
Modern rheumatology, Feb-28, Volume: 32, Issue: 2
2022
Efficacy and safety of filgotinib in combination with methotrexate in Japanese patients with active rheumatoid arthritis who have an inadequate response to methotrexate: Subpopulation analyses of 24-week data of a global phase 3 study (FINCH 1).
Modern rheumatology, Feb-28, Volume: 32, Issue: 2
2022
Efficacy and safety of selinexor in the treatment of AML: A protocol for systematic review and meta-analysis.
Medicine, Dec-10, Volume: 100, Issue: 49
2021
Chiral fungicide penconazole: Absolute configuration, bioactivity, toxicity, and stereoselective degradation in apples.
The Science of the total environment, Feb-20, Volume: 808
2022
Ecotoxicity of herbicide carfentrazone-ethyl towards earthworm Eisenia fetida in soil.
Comparative biochemistry and physiology. Toxicology & pharmacology : CBP, Volume: 253
2022
Design, Synthesis, biological investigations and molecular interactions of triazole linked tacrine glycoconjugates as Acetylcholinesterase inhibitors with reduced hepatotoxicity.
Bioorganic chemistry, Volume: 118
2022
Selective Orexin Receptor Antagonists as Novel Augmentation Treatments for Major Depressive Disorder: Evidence for Safety and Efficacy From a Phase 2B Study of Seltorexant.
The international journal of neuropsychopharmacology, 01-12, Volume: 25, Issue: 1
2022
Evaluating posaconazole, its pharmacology, efficacy and safety for the prophylaxis and treatment of fungal infections.
Expert opinion on pharmacotherapy, Volume: 23, Issue: 2
2022
Permeabilized Cryopreserved Human Hepatocytes as an Exogenous Metabolic System in a Novel Metabolism-Dependent Cytotoxicity Assay for the Evaluation of Metabolic Activation and Detoxification of Drugs Associated with Drug-Induced Liver Injuries: Results w
Drug metabolism and disposition: the biological fate of chemicals, Volume: 50, Issue: 2
2022
Integrated safety analysis of filgotinib in patients with moderately to severely active rheumatoid arthritis receiving treatment over a median of 1.6 years.
Annals of the rheumatic diseases, Volume: 81, Issue: 2
2022
A comprehensive review of 1,2,4-triazole fungicide toxicity in zebrafish (Danio rerio): A mitochondrial and metabolic perspective.
The Science of the total environment, Feb-25, Volume: 809
2022
1,2,3-Triazole derivatives: synthesis, docking, cytotoxicity analysis and in vivo antimalarial activity.
Chemico-biological interactions, Dec-01, Volume: 350
2021
The discovery of combined toxicity effects and mechanisms of hexaconazole and arsenic to mice based on untargeted metabolomics.
Ecotoxicology and environmental safety, Dec-15, Volume: 226
2021
Potential neurotoxicity, immunotoxicity, and carcinogenicity induced by metribuzin and tebuconazole exposure in earthworms (Eisenia fetida) revealed by transcriptome analysis.
The Science of the total environment, Feb-10, Volume: 807, Issue: Pt 1
2022
Bromuconazole caused genotoxicity and hepatic and renal damage via oxidative stress process in Wistar rats.
Environmental science and pollution research international, Volume: 29, Issue: 10
2022
Efficacy and safety of antiseizure medication for Lennox-Gastaut syndrome: a systematic review and network meta-analysis.
Developmental medicine and child neurology, Volume: 64, Issue: 3
2022
Efficacy and Safety of Molidustat for Anemia in ESA-Naive Nondialysis Patients: A Randomized, Phase 3 Trial.
American journal of nephrology, Volume: 52, Issue: 10-11
2021
Comparison of the Effectiveness and Safety of the Oral Selective Inhibitor of Nuclear Export, Selinexor, in Diffuse Large B Cell Lymphoma Subtypes.
Clinical lymphoma, myeloma & leukemia, Volume: 22, Issue: 1
2022
Efficacy and safety of filgotinib in methotrexate-naive patients with rheumatoid arthritis with poor prognostic factors: post hoc analysis of FINCH 3.
RMD open, Volume: 7, Issue: 2
2021
Acute toxicity of the insecticide abamectin and the fungicide difenoconazole (individually and in mixture) to the tropical stingless bee Melipona scutellaris.
Ecotoxicology (London, England), Volume: 30, Issue: 9
2021
Degradation of difenoconazole in water and soil: Kinetics, degradation pathways, transformation products identification and ecotoxicity assessment.
Journal of hazardous materials, 09-15, Volume: 418
2021
Efficacy and Safety of Seltorexant as Adjunctive Therapy in Major Depressive Disorder: A Phase 2b, Randomized, Placebo-Controlled, Adaptive Dose-Finding Study.
The international journal of neuropsychopharmacology, 12-08, Volume: 24, Issue: 12
2021
Efficacy and safety of rufinamide as adjunctive therapy in patients with Lennox Gastaut syndrome: A systematic review and Meta-analysis.
Seizure, Volume: 91
2021
Histology and multi-omic profiling reveal the mixture toxicity of tebuconazole and difenoconazole in adult zebrafish.
The Science of the total environment, Nov-15, Volume: 795
2021
In silico modelling of acute toxicity of 1, 2, 4-triazole antifungal agents towards zebrafish (Danio rerio) embryos: Application of the Small Dataset Modeller tool.
Toxicology in vitro : an international journal published in association with BIBRA, Volume: 75
2021
Transcriptomic changes upon epoxiconazole exposure in a human stem cell-based model of developmental toxicity.
Chemosphere, Volume: 284
2021
QSCR Analysis of Cytotoxicity of 6-Fluoro-3-(4H-1,2,4-triazol-3- yl)quinolin-4(1H)-ones on Chinese Hamster Ovary Cell Line: Design of REPUBLIC1986.
Current medicinal chemistry, Volume: 29, Issue: 2
2022
Cytotoxic 1,2,3-Triazoles as Potential Leads Targeting the S100A2-p53 Complex: Synthesis and Cytotoxicity.
ChemMedChem, 09-16, Volume: 16, Issue: 18
2021
Efficacy and safety of isavuconazole compared with voriconazole as primary antifungal prophylaxis in allogeneic hematopoietic cell transplant recipients.
Medical mycology, Oct-04, Volume: 59, Issue: 10
2021
The safety of JAK-1 inhibitors.
Rheumatology (Oxford, England), 05-05, Volume: 60, Issue: Suppl 2
2021
A toxicogenomics approach reveals characteristics supporting the honey bee (Apis mellifera L.) safety profile of the butenolide insecticide flupyradifurone.
Ecotoxicology and environmental safety, Jul-01, Volume: 217
2021
Tebuconazole induced cytotoxic and genotoxic effects in HCT116 cells through ROS generation.
Pesticide biochemistry and physiology, Volume: 174
2021
Synthesis of sorafenib analogues incorporating a 1,2,3-triazole ring and cytotoxicity towards hepatocellular carcinoma cell lines.
Bioorganic chemistry, Volume: 112
2021
Three widely used pesticides and their mixtures induced cytotoxicity and apoptosis through the ROS-related caspase pathway in HepG2 cells.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, Volume: 152
2021
Design of molecular hybrids of phthalimide-triazole agents with potent selective MCF-7/HepG2 cytotoxicity: Synthesis, EGFR inhibitory effect, and metabolic stability.
Bioorganic chemistry, Volume: 111
2021
Fungicide bromuconazole has the potential to induce hepatotoxicity at the physiological, metabolomic and transcriptomic levels in rats.
Environmental pollution (Barking, Essex : 1987), Jul-01, Volume: 280
2021
Early Toxic Effects in a Central American Native Fish (Parachromis dovii) Exposed to Chlorpyrifos and Difenoconazole.
Environmental toxicology and chemistry, Volume: 40, Issue: 7
2021
Overview of Ocular Side Effects of Selinexor.
The oncologist, Volume: 26, Issue: 7
2021
Evaluation of triazophos induced immunotoxicity of spleen and head kidney in fresh water teleost, Channa punctata.
Comparative biochemistry and physiology. Toxicology & pharmacology : CBP, Volume: 245
2021
Tebuconazole-induced toxicity and the protective effect of Ficus carica extract in Neotropical fruit-eating bats.
Chemosphere, Volume: 275
2021
TNFα enhances trovafloxacin-induced in vitro hepatotoxicity by inhibiting protective autophagy.
Toxicology letters, May-15, Volume: 342
2021
Efficacy, safety and central nervous system effects after switch from efavirenz/tenofovir/emtricitabine to doravirine/tenofovir/lamivudine.
AIDS (London, England), 04-01, Volume: 35, Issue: 5
2021
Long-term Efficacy and Safety of Once-daily Efinaconazole 10% Topical Solution (Jublia) for Dermatophyte Toenail Onychomycosis: An Interim Analysis.
Skin therapy letter, Volume: 26, Issue: 1
2021
Safety and Efficacy of Filgotinib: Up to 4-year Results From an Open-label Extension Study of Phase II Rheumatoid Arthritis Programs.
The Journal of rheumatology, Volume: 48, Issue: 8
2021
Neuroprotective effects of Myricetin on Epoxiconazole-induced toxicity in F98 cells.
Free radical biology & medicine, 02-20, Volume: 164
2021
Phase II, randomised, double-blind, multicentre study evaluating the safety and efficacy of filgotinib and lanraplenib in patients with lupus membranous nephropathy.
RMD open, Volume: 6, Issue: 3
2020
Incorporating lines of evidence from New Approach Methodologies (NAMs) to reduce uncertainties in a category based read-across: A case study for repeated dose toxicity.
Regulatory toxicology and pharmacology : RTP, Volume: 120
2021
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Long-term Use (83)

ArticleYear
Voriconazole-induced periostitis.
Reumatismo, Apr-19, Volume: 73, Issue: 1
2021
Effect of Chronic Administration of 5-(3-chlorophenyl)-4-Hexyl-2,4 -Dihydro-3
International journal of molecular sciences, Mar-25, Volume: 22, Issue: 7
2021
Rufinamide add-on therapy for drug-resistant epilepsy.
The Cochrane database of systematic reviews, 11-08, Volume: 11
2020
Dementia-Like Symptoms Associated With Posaconazole.
Journal of pharmacy practice, Volume: 35, Issue: 1
2022
1,2,3-Triazole hybrids with anti-HIV-1 activity.
Archiv der Pharmazie, Volume: 354, Issue: 1
2021
Induced expression of CYP51 associated with difenoconazole resistance in the pathogenic Alternaria sect. on potato in China.
Pest management science, Volume: 76, Issue: 5
2020
Efficacy of long-term treatment with efinaconazole 10% solution in patients with onychomycosis, including severe cases: A multicenter, single-arm study.
The Journal of dermatology, Volume: 46, Issue: 8
2019
Ghrelin signalling within the rat nucleus accumbens and skilled reach foraging.
Psychoneuroendocrinology, Volume: 106
2019
Lack of Toxicity With Long-term Isavuconazole Use in Patients With Hematologic Malignancy.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 10-15, Volume: 69, Issue: 9
2019
Re-examining the potential of targeting ABHD6 in multiple sclerosis: Efficacy of systemic and peripherally restricted inhibitors in experimental autoimmune encephalomyelitis.
Neuropharmacology, Volume: 141
2018
Rufinamide add-on therapy for refractory epilepsy.
The Cochrane database of systematic reviews, 04-25, Volume: 4
2018
The Y137H mutation in the cytochrome P450 FgCYP51B protein confers reduced sensitivity to tebuconazole in Fusarium graminearum.
Pest management science, Volume: 74, Issue: 6
2018
Long-term efficacy and safety of aromatase inhibitor use for leiomyomatosis peritonealis disseminata.
The journal of obstetrics and gynaecology research, Volume: 43, Issue: 9
2017
Residue and intake risk assessment of prothioconazole and its metabolite prothioconazole-desthio in wheat field.
Environmental monitoring and assessment, Volume: 189, Issue: 5
2017
The EP4 antagonist, L-161,982, induces apoptosis, cell cycle arrest, and inhibits prostaglandin E2-induced proliferation in oral squamous carcinoma Tca8113 cells.
Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology, Volume: 46, Issue: 10
2017
Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibitors: A Potential New Treatment for Anemia in Patients With CKD.
American journal of kidney diseases : the official journal of the National Kidney Foundation, Volume: 69, Issue: 6
2017
Effect of imatinib on growth of experimental endometriosis in rats.
European journal of obstetrics, gynecology, and reproductive biology, Volume: 197
2016
Beneficial properties of maraviroc on neuropathic pain development and opioid effectiveness in rats.
Progress in neuro-psychopharmacology & biological psychiatry, Jan-04, Volume: 64
2016
Structure-function-behavior relationship in estrogen-induced synaptic plasticity.
Hormones and behavior, Volume: 74
2015
Unprecedented therapeutic potential with a combination of A2A/NR2B receptor antagonists as observed in the 6-OHDA lesioned rat model of Parkinson's disease.
PloS one, Volume: 9, Issue: 12
2014
Renoprotective effect of sitagliptin against hypertensive nephropathy induced by chronic administration of L-NAME in rats: role of GLP-1 and GLP-1 receptor.
European journal of pharmacology, Nov-15, Volume: 720, Issue: 1-3
2013
Posaconazole vs. fluconazole as invasive fungal infection prophylaxis in China: a multicenter, randomized, open-label study.
International journal of clinical pharmacology and therapeutics, Volume: 51, Issue: 9
2013
Multifocal periostitis as a complication of chronic use of voriconazole in a lung transplant recipient.
Transplant infectious disease : an official journal of the Transplantation Society, Volume: 15, Issue: 4
2013
Long-term treatment with Sitagliptin, a dipeptidyl peptidase-4 inhibitor, reduces colon carcinogenesis and reactive oxygen species in 1,2-dimethylhydrazine-induced rats.
International journal of cancer, Nov-15, Volume: 133, Issue: 10
2013
Alleviating anastrozole induced bone toxicity by selenium nanoparticles in SD rats.
Toxicology and applied pharmacology, Apr-15, Volume: 268, Issue: 2
2013
Combination of a selective activator of the glucocorticoid receptor Compound A with a proteasome inhibitor as a novel strategy for chemotherapy of hematologic malignancies.
Cell cycle (Georgetown, Tex.), Jan-01, Volume: 12, Issue: 1
2013
Increased incidence of cutaneous squamous cell carcinoma in lung transplant recipients taking long-term voriconazole.
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation, Volume: 31, Issue: 11
2012
A case of aromatase inhibitor (anastrozole)-induced side-effects successfully treated with Kampo medicines.
Journal of alternative and complementary medicine (New York, N.Y.), Volume: 17, Issue: 11
2011
Periostitis secondary to prolonged voriconazole therapy in a lung transplant recipient.
Orthopedics, Nov-09, Volume: 34, Issue: 11
2011
Modulatory effects of the CCR5 antagonist maraviroc on microglial pro-inflammatory activation elicited by gp120.
Journal of neurochemistry, Volume: 120, Issue: 1
2012
Successful long-term use of sitagliptin for the treatment of new-onset diabetes mellitus after solid organ transplantation: a case report.
Transplantation proceedings, Volume: 43, Issue: 5
2011
Use of aromatase inhibitors to treat endometriosis-related pain symptoms: a systematic review.
Reproductive biology and endocrinology : RB&E, Jun-21, Volume: 9
2011
Selective adenosine A2A receptor agonists and antagonists protect against spinal cord injury through peripheral and central effects.
Journal of neuroinflammation, Apr-12, Volume: 8
2011
Prophylactic neuroprotection against stroke: low-dose, prolonged treatment with deferoxamine or deferasirox establishes prolonged neuroprotection independent of HIF-1 function.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, Volume: 31, Issue: 6
2011
Periostitis secondary to prolonged voriconazole therapy in lung transplant recipients.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, Volume: 9, Issue: 12
2009
Posaconazole's impact on prophylaxis and treatment of invasive fungal infections: an update.
Expert review of anti-infective therapy, Volume: 7, Issue: 2
2009
Caffeine and a selective adenosine A2A receptor antagonist induce reward and sensitization behavior associated with increased phospho-Thr75-DARPP-32 in mice.
Psychopharmacology, Volume: 204, Issue: 2
2009
Voriconazole-induced photosensitivity.
Clinical medicine & research, Volume: 6, Issue: 2
2008
A safety, pharmacokinetic and pharmacodynamic investigation of deferasirox (Exjade, ICL670) in patients with transfusion-dependent anemias and iron-overload: a Phase I study in Japan.
International journal of hematology, Volume: 88, Issue: 1
2008
Central versus peripheral antagonism of cannabinoid CB1 receptor in obesity: effects of LH-21, a peripherally acting neutral cannabinoid receptor antagonist, in Zucker rats.
Journal of neuroendocrinology, Volume: 20 Suppl 1
2008
Complexity of interactions between voriconazole and antiretroviral agents.
The Annals of pharmacotherapy, Volume: 42, Issue: 5
2008
Relative response of patients with myelodysplastic syndromes and other transfusion-dependent anaemias to deferasirox (ICL670): a 1-yr prospective study.
European journal of haematology, Volume: 80, Issue: 2
2008
Characterization of the antiparkinsonian effects of the new adenosine A2A receptor antagonist ST1535: acute and subchronic studies in rats.
European journal of pharmacology, Jul-02, Volume: 566, Issue: 1-3
2007
Continuing with letrozole offers greater benefits.
Journal of cancer research and clinical oncology, Volume: 133, Issue: 7
2007
Antiobesity effects of the novel in vivo neutral cannabinoid receptor antagonist 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-3-hexyl-1H-1,2,4-triazole--LH 21.
Neuropharmacology, Volume: 51, Issue: 2
2006
Safety considerations of adjuvant therapy in early breast cancer in postmenopausal women.
Oncology, Volume: 69, Issue: 1
2005
Refractory coccidioidomycosis treated with posaconazole.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, Jun-15, Volume: 40, Issue: 12
2005
Effects of adenosine and adenosine A2A receptor agonist on motor nerve conduction velocity and nerve blood flow in experimental diabetic neuropathy.
Neurological research, Volume: 27, Issue: 1
2005
Rizatriptan 5 mg for the acute treatment of migraine in adolescents: results from a double-blind, single-attack study and two open-label, multiple-attack studies.
Headache, Volume: 44, Issue: 9
2004
Posaconazole: a potent, extended-spectrum triazole anti-fungal for the treatment of serious fungal infections.
International journal of clinical practice, Volume: 58, Issue: 6
2004
The effects of hormone therapy on cognition in breast cancer.
The Journal of steroid biochemistry and molecular biology, Volume: 86, Issue: 3-5
2003
High-risk AML complicated by pulmonary aspergillosis: successful treatment with nonmyeloablative stem cell transplantation and long-term administration of voriconazole.
Annals of hematology, Volume: 83, Issue: 2
2004
Pharmacokinetics of third-generation aromatase inhibitors.
Seminars in oncology, Volume: 30, Issue: 4 Suppl 14
2003
Aromatase inhibition for the treatment of idiopathic hypogonadotropic hypogonadism in men with premature ejaculation.
Southern medical journal, Volume: 96, Issue: 6
2003
Involvement of adenosine A1 and A2A receptors in the motor effects of caffeine after its acute and chronic administration.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, Volume: 28, Issue: 7
2003
Long-term side effects of newer-generation antidepressants: SSRIS, venlafaxine, nefazodone, bupropion, and mirtazapine.
Annals of clinical psychiatry : official journal of the American Academy of Clinical Psychiatrists, Volume: 14, Issue: 3
2002
Mechanisms for the induction of oxidative stress in Syrian hamster embryo cells by acrylonitrile.
Toxicological sciences : an official journal of the Society of Toxicology, Volume: 67, Issue: 2
2002
Interaction between dopamine and adenosine A2A receptors as a basis for the treatment of Parkinson's disease.
Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, Volume: 22, Issue: 1
2001
Protein binding alters the activity of suramin, carboxyamidotriazole, and UCN-01 in an ex vivo rat aortic ring angiogenesis assay.
Clinical cancer research : an official journal of the American Association for Cancer Research, Volume: 7, Issue: 7
2001
Regulation of ionotropic glutamate receptor subunits in different rat brain areas by a preferential sigma(1) receptor ligand and potential atypical antipsychotic.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, Volume: 23, Issue: 5
2000
Nefazodone and the treatment of nonparaphilic compulsive sexual behavior: a retrospective study.
The Journal of clinical psychiatry, Volume: 61, Issue: 4
2000
The anxiogenic-like effect of caffeine in two experimental procedures measuring anxiety in the mouse is not shared by selective A(2A) adenosine receptor antagonists.
Psychopharmacology, Volume: 148, Issue: 2
2000
Effect of chronic administration of an aromatase inhibitor to adult male rats on pituitary and testicular function and fertility.
The Journal of endocrinology, Volume: 164, Issue: 2
2000
Electrophysiological effects of E-5842, a sigma1 receptor ligand and potential atypical antipsychotic, on A9 and A10 dopamine neurons.
European journal of pharmacology, Jul-28, Volume: 378, Issue: 1
1999
Captopril and platelet-activating factor (PAF) antagonist prevent cardiac allograft vasculopathy in rats: role of endogenous PAF and PAF-like compounds.
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation, Volume: 18, Issue: 5
1999
[Biochemical and immunohistological changes in the gastric mucosa of rats with long-term administration of histamine H2-receptor antagonist].
Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology, Volume: 95, Issue: 12
1998
Letrozole. A review of its use in postmenopausal women with advanced breast cancer.
Drugs, Volume: 56, Issue: 6
1998
Novel serotonergic mechanisms and clinical experience with nefazodone.
Clinical neuropharmacology, Volume: 16 Suppl 3
1993
Vorozole, a specific non-steroidal aromatase inhibitor.
Breast cancer research and treatment, Volume: 30, Issue: 1
1994
The serotonergic antidepressant nefazodone inhibits the serotonin transporter: in vivo and ex vivo studies.
Life sciences, Volume: 57, Issue: 24
1995
Amitrole: strain differences in morphological response of the liver following subchronic administration to mice.
Toxicology letters, Volume: 29, Issue: 2-3
1985
Down-regulation of serotonin2, but not of beta-adrenergic receptors during chronic treatment with amitriptyline is independent of stimulation of serotonin2 and beta-adrenergic receptors.
Neuropharmacology, Volume: 25, Issue: 12
1986
Oral fluconazole as suppressive therapy of disseminated cryptococcosis in patients with acquired immunodeficiency syndrome.
The American journal of medicine, Volume: 85, Issue: 4
1988
The effects of a potential antidepressant, 2,4-dimethyl-5-(3-fluorophenyl)-3H-1,2,4-triazole-3-thione, in an electrophysiological model responsive to desipramine.
Neuropharmacology, Volume: 29, Issue: 6
1990
Nefazodone: preclinical pharmacology of a new antidepressant.
Psychopharmacology bulletin, Volume: 26, Issue: 3
1990
Endocrine and antitumoral effects of R76713 in rats.
Journal of enzyme inhibition, Volume: 4, Issue: 2
1990
Chronic administration of H2-antagonists does not alter gastric secretory responses to histamine, or the antisecretory activity of sufotidine.
Alimentary pharmacology & therapeutics, Volume: 4 Suppl 1
1990
Potential hazards of long-term acid suppression.
Scandinavian journal of gastroenterology. Supplement, Volume: 178
1990
Evidence for platelet-activating factor as a late-phase mediator of chronic pancreatitis in the rat.
The American journal of pathology, Volume: 137, Issue: 6
1990
Anticonvulsant profile of MDL 27,266: an orally active, broad-spectrum anticonvulsant agent.
Epilepsy research, Volume: 12, Issue: 3
1992
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Pharmacokinetics (600)

ArticleYear
High Variability in Isavuconazole Unbound Fraction in Clinical Practice: A Call to Reconsider Pharmacokinetic/Pharmacodynamic Targets and Breakpoints.
Clinical pharmacokinetics, Volume: 62, Issue: 12
2023
Population Pharmacokinetics of Total and Unbound Isavuconazole in Critically Ill Patients: Implications for Adaptive Dosing Strategies.
Clinical pharmacokinetics, Volume: 62, Issue: 12
2023
Pharmacokinetic and Exposure Response Analysis of the Double-Blind Randomized Study of Posaconazole and Voriconazole for Treatment of Invasive Aspergillosis.
Clinical drug investigation, Volume: 43, Issue: 9
2023
[Comparative clinical study of pharmacokinetics and bioequivalence of Relonova and Maxalt].
Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova, Volume: 123, Issue: 8
2023
Population Pharmacokinetics of Posaconazole in Immune-Compromised Children and Assessment of Target Attainment in Invasive Fungal Disease.
Clinical pharmacokinetics, Volume: 62, Issue: 7
2023
New Targeted Drugs for Acute Myeloid Leukemia and Antifungals: Pharmacokinetic Challenges and Opportunities.
Chemotherapy, Volume: 68, Issue: 3
2023
A Hybrid Algorithm Combining Population Pharmacokinetic and Machine Learning for Isavuconazole Exposure Prediction.
Pharmaceutical research, Volume: 40, Issue: 4
2023
Population Pharmacokinetics, Exposure-Safety, and Probability of Target Attainment Analyses for Isavuconazole in Japanese Patients With Deep-Seated Mycoses.
Journal of clinical pharmacology, Volume: 63, Issue: 6
2023
An Integrated Population Pharmacokinetic Analysis for Posaconazole Oral Suspension, Delayed-Release Tablet, and Intravenous Infusion in Healthy Volunteers.
Drugs, Volume: 83, Issue: 1
2023
A Review of Population Pharmacokinetic Models of Posaconazole.
Drug design, development and therapy, Volume: 16
2022
Population pharmacokinetics of posaconazole in Chinese pediatric patients with acute leukaemia: Effect of food on bioavailability and dose optimization.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, Nov-01, Volume: 178
2022
Safe administration and pharmacokinetic monitoring of crushed venetoclax tablets with posaconazole and clarithromycin via percutaneous endoscopic gastrostomy tube in a patient with acute myeloid leukemia.
Cancer chemotherapy and pharmacology, Volume: 90, Issue: 3
2022
External evaluation of population pharmacokinetic models for voriconazole in Chinese adult patients with hematological malignancy.
European journal of clinical pharmacology, Volume: 78, Issue: 9
2022
Pharmacokinetics of isavuconazole in healthy cats after oral and intravenous administration.
Journal of veterinary internal medicine, Volume: 36, Issue: 4
2022
Prediction of Maternal and Fetal Doravirine Exposure by Integrating Physiologically Based Pharmacokinetic Modeling and Human Placenta Perfusion Experiments.
Clinical pharmacokinetics, Volume: 61, Issue: 8
2022
Exposure to intravenous posaconazole in critically ill patients with influenza: A pharmacokinetic analysis of the POSA-FLU study.
Mycoses, Volume: 65, Issue: 6
2022
Ganetespib selectively sensitizes cancer cells for proximal and distal spread-out Bragg peak proton irradiation.
Radiation oncology (London, England), Apr-11, Volume: 17, Issue: 1
2022
Pharmacokinetics, Safety, and Tolerability of Single and Multiple Doses of Isavuconazonium Sulfate in Healthy Adult Japanese Subjects.
Clinical pharmacology in drug development, Volume: 11, Issue: 6
2022
Use of Modeling and Simulation to Predict the Influence of Triazole Antifungal Agents on the Pharmacokinetics of Crizotinib.
Clinical pharmacology in drug development, Volume: 11, Issue: 6
2022
Proof of Concept in Assignment of Within-Subject Variability During Virtual Bioequivalence Studies: Propagation of Intra-Subject Variation in Gastrointestinal Physiology Using Physiologically Based Pharmacokinetic Modeling.
The AAPS journal, 01-05, Volume: 24, Issue: 1
2022
Population pharmacokinetics of a posaconazole tablet formulation in transplant adult allogeneic stem cell recipients.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, Jan-01, Volume: 168
2022
Assessment of the Effect of Filgotinib on the Pharmacokinetics of Atorvastatin, Pravastatin, and Rosuvastatin in Healthy Adult Participants.
Clinical pharmacology in drug development, Volume: 11, Issue: 2
2022
Clinical pharmacokinetics and dose recommendations for posaconazole gastroresistant tablets in children with cystic fibrosis.
The Journal of antimicrobial chemotherapy, 11-12, Volume: 76, Issue: 12
2021
Pharmacokinetics and Bioequivalence of Isavuconazole Administered as Isavuconazonium Sulfate Intravenous Solution via Nasogastric Tube or Orally in Healthy Subjects.
Antimicrobial agents and chemotherapy, 08-17, Volume: 65, Issue: 9
2021
Leveraging Physiologically Based Pharmacokinetic Modeling and Experimental Data to Guide Dosing Modification of CYP3A-Mediated Drug-Drug Interactions in the Pediatric Population.
Drug metabolism and disposition: the biological fate of chemicals, Volume: 49, Issue: 9
2021
A Target-Mediated Drug Disposition Model to Explain Nonlinear Pharmacokinetics of the 11β-Hydroxysteroid Dehydrogenase Type 1 Inhibitor SPI-62 in Healthy Adults.
Journal of clinical pharmacology, Volume: 61, Issue: 11
2021
Development of UPLC-MS/MS Method for Studying the Pharmacokinetic Interaction Between Dasatinib and Posaconazole in Rats.
Drug design, development and therapy, Volume: 15
2021
Intestinal Excretion, Intestinal Recirculation, and Renal Tubule Reabsorption Are Underappreciated Mechanisms That Drive the Distribution and Pharmacokinetic Behavior of Small Molecule Drugs.
Journal of medicinal chemistry, 06-10, Volume: 64, Issue: 11
2021
Clinical Pharmacokinetics of Triazoles in Pediatric Patients.
Clinical pharmacokinetics, Volume: 60, Issue: 9
2021
Establishment and Verification of UPLC-MS/MS Technique for Pharmacokinetic Drug-Drug Interactions of Selinexor with Posaconazole in Rats.
Drug design, development and therapy, Volume: 15
2021
Hemodialysis Clearance of Enarodustat (JTZ-951), an Oral Erythropoiesis Stimulating Agent, in Patients with End-Stage Renal Disease.
Clinical pharmacology in drug development, Volume: 10, Issue: 5
2021
Selinexor population pharmacokinetic and exposure-response analyses to support dose optimization in patients with diffuse large B-cell lymphoma.
Cancer chemotherapy and pharmacology, Volume: 88, Issue: 1
2021
JAK selectivity and the implications for clinical inhibition of pharmacodynamic cytokine signalling by filgotinib, upadacitinib, tofacitinib and baricitinib.
Annals of the rheumatic diseases, Volume: 80, Issue: 7
2021
A Population Pharmacokinetic Modeling and Simulation Study of Posaconazole Oral Suspension in Immunocompromised Pediatric Patients: A Short Communication.
Therapeutic drug monitoring, 08-01, Volume: 43, Issue: 4
2021
Pharmacokinetics and target attainment of intravenous posaconazole in critically ill patients during extracorporeal membrane oxygenation.
The Journal of antimicrobial chemotherapy, 04-13, Volume: 76, Issue: 5
2021
Pharmacokinetics and tolerability of intravenous posaconazole in healthy Chinese volunteers: a randomized, open-label and single-dose study.
Die Pharmazie, 10-01, Volume: 75, Issue: 10
2020
Comparison of the Pharmacokinetics of RIPK1 Inhibitor GSK2982772 in Healthy Western and Japanese Subjects.
European journal of drug metabolism and pharmacokinetics, Volume: 46, Issue: 1
2021
Discovery of IPN60090, a Clinical Stage Selective Glutaminase-1 (GLS-1) Inhibitor with Excellent Pharmacokinetic and Physicochemical Properties.
Journal of medicinal chemistry, 11-12, Volume: 63, Issue: 21
2020
Differential Impacts of Azole Antifungal Drugs on the Pharmacokinetic Profiles of Dasatinib in Rats by LC-MS-MS.
Current drug metabolism, Volume: 21, Issue: 13
2020
Safety, Pharmacokinetics, and Efficacy of Efinaconazole 10% Topical Solution for Onychomycosis Treatment in Pediatric Patients.
Journal of drugs in dermatology : JDD, Sep-01, Volume: 19, Issue: 9
2020
Physiologically Based Pharmacokinetic Modeling of Doravirine and Its Major Metabolite to Support Dose Adjustment With Rifabutin.
Journal of clinical pharmacology, Volume: 61, Issue: 3
2021
Navafenterol (AZD8871) in patients with mild asthma: a randomised placebo-controlled phase I study evaluating the safety, tolerability, pharmacokinetics, and pharmacodynamics of single ascending doses of this novel inhaled long-acting dual-pharmacology br
Respiratory research, Sep-09, Volume: 21, Issue: Suppl 1
2020
Navafenterol (AZD8871) in healthy volunteers: safety, tolerability and pharmacokinetics of multiple ascending doses of this novel inhaled, long-acting, dual-pharmacology bronchodilator, in two phase I, randomised, single-blind, placebo-controlled studies.
Respiratory research, Sep-09, Volume: 21, Issue: Suppl 1
2020
Navafenterol (AZD8871) in patients with COPD: a randomized, double-blind, phase I study evaluating safety and pharmacodynamics of single doses of this novel, inhaled, long-acting, dual-pharmacology bronchodilator.
Respiratory research, Sep-09, Volume: 21, Issue: Suppl 1
2020
Population Pharmacokinetic and Pharmacodynamic Analysis To Evaluate a Switch to Doravirine/Lamivudine/Tenofovir Disoproxil Fumarate in People Living with HIV-1.
Antimicrobial agents and chemotherapy, 10-20, Volume: 64, Issue: 11
2020
Clinical Pharmacokinetics of the Novel HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitor Doravirine: An Assessment of the Effect of Patient Characteristics and Drug-Drug Interactions.
Clinical drug investigation, Volume: 40, Issue: 10
2020
Antifungal drugs: An updated review of central nervous system pharmacokinetics.
Mycoses, Volume: 63, Issue: 10
2020
Evaluating posaconazole dosing regimens of the different formulations against Aspergillus spp. in adults: a pharmacokinetic/pharmacodynamic analysis using Monte Carlo simulation.
International journal of antimicrobial agents, Volume: 56, Issue: 4
2020
Application of Azamulin to Determine the Contribution of CYP3A4/5 to Drug Metabolic Clearance Using Human Hepatocytes.
Drug metabolism and disposition: the biological fate of chemicals, Volume: 48, Issue: 9
2020
Pharmacokinetics, safety and tolerability of long-acting parenteral intramuscular injection formulations of doravirine.
Journal of clinical pharmacy and therapeutics, Volume: 45, Issue: 5
2020
Posaconazole in prophylaxis and treatment of invasive fungal infections: a pharmacokinetic, pharmacodynamic and clinical evaluation.
Expert opinion on drug metabolism & toxicology, Volume: 16, Issue: 7
2020
From bench to bedside: Perspectives on the utility of pharmacokinetics/pharmacodynamics in predicting the efficacy of antifungals in invasive candidiasis.
Mycoses, Volume: 63, Issue: 8
2020
Pharmacokinetics and Pharmacodynamics of Posaconazole.
Drugs, Volume: 80, Issue: 7
2020
Characterisation of the pharmacodynamic effects of the P2X7 receptor antagonist JNJ-54175446 using an oral dexamphetamine challenge model in healthy males in a randomised, double-blind, placebo-controlled, multiple ascending dose trial.
Journal of psychopharmacology (Oxford, England), Volume: 34, Issue: 9
2020
The Pharmacokinetic-Pharmacodynamic (PKPD) Relationships of AZD3229, a Novel and Selective Inhibitor of KIT, in a Range of Mouse Xenograft Models of GIST.
Clinical cancer research : an official journal of the American Association for Cancer Research, 07-15, Volume: 26, Issue: 14
2020
Antimicrobial screening and pharmacokinetic profiling of novel phenyl-[1,2,4]triazolo[4,3-a]quinoxaline analogues targeting DHFR and E. coli DNA gyrase B.
Bioorganic chemistry, Volume: 96
2020
Development of an oral bentonite-based modified-release freeze-dried powder of vactosertib: Pharmacokinetics and anti-colitis activity in rodent models of ulcerative colitis.
International journal of pharmaceutics, Mar-30, Volume: 578
2020
Effects of oral iron and calcium supplement on the pharmacokinetics and pharmacodynamics of molidustat: an oral HIF-PH inhibitor for the treatment of renal anaemia.
European journal of clinical pharmacology, Volume: 76, Issue: 2
2020
The Effects of Special Patient Population Plasma on Pharmacokinetic Quantifications Using LC-MS/MS.
Drug metabolism letters, Volume: 13, Issue: 2
2019
Comparative in vitro pharmacodynamic analysis of isavuconazole, voriconazole, and posaconazole against clinical isolates of aspergillosis, mucormycosis, fusariosis, and phaeohyphomycosis.
Diagnostic microbiology and infectious disease, Volume: 95, Issue: 3
2019
Clinical Pharmacodynamics, Pharmacokinetics, and Drug Interaction Profile of Doravirine.
Clinical pharmacokinetics, Volume: 58, Issue: 12
2019
A population pharmacokinetic analysis of the oral CYP17 lyase and androgen receptor inhibitor seviteronel in patients with advanced/metastatic castration-resistant prostate cancer or breast cancer.
Cancer chemotherapy and pharmacology, Volume: 84, Issue: 4
2019
Population pharmacokinetics of cyclosporine in Chinese children receiving hematopoietic stem cell transplantation.
Acta pharmacologica Sinica, Volume: 40, Issue: 12
2019
Population pharmacokinetics of total and unbound concentrations of intravenous posaconazole in adult critically ill patients.
Critical care (London, England), Jun-06, Volume: 23, Issue: 1
2019
Evaluation of the Pharmacokinetic Interaction Between Doravirine and Methadone.
Clinical pharmacology in drug development, Volume: 9, Issue: 2
2020
Evaluation of the Pharmacokinetics of Metformin Following Coadministration With Doravirine in Healthy Volunteers.
Clinical pharmacology in drug development, Volume: 9, Issue: 1
2020
A non-randomized trial to assess the safety, tolerability, and pharmacokinetics of posaconazole oral suspension in immunocompromised children with neutropenia.
PloS one, Volume: 14, Issue: 3
2019
Ultra-performance hydrophilic interaction liquid chromatography coupled with tandem mass spectrometry for simultaneous determination of allopurinol, oxypurinol and lesinurad in rat plasma: Application to pharmacokinetic study in rats.
PloS one, Volume: 14, Issue: 3
2019
The impact of initiating posaconazole on tacrolimus pharmacokinetics in allogeneic stem cell transplantation.
Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners, Volume: 26, Issue: 1
2020
Effect of CYP3A Inhibition and Induction on the Pharmacokinetics of Suvorexant: Two Phase I, Open-Label, Fixed-Sequence Trials in Healthy Subjects.
Clinical drug investigation, Volume: 39, Issue: 5
2019
Pharmacokinetic stability of macrocyclic peptide triazole HIV-1 inactivators alone and in liposomes.
Journal of peptide science : an official publication of the European Peptide Society, Volume: 25, Issue: 4
2019
Lesinurad: Evaluation of Pharmacokinetic and Pharmacodynamic Interactions With Warfarin in Healthy Volunteers.
Clinical pharmacology in drug development, Volume: 8, Issue: 5
2019
Population Pharmacokinetics of Doravirine and Exposure-Response Analysis in Individuals with HIV-1.
Antimicrobial agents and chemotherapy, Volume: 63, Issue: 4
2019
Safety, Pharmacokinetics, and Pharmacodynamics of ASP3662, a Novel 11β-Hydroxysteroid Dehydrogenase Type 1 Inhibitor, in Healthy Young and Elderly Subjects.
Clinical and translational science, Volume: 12, Issue: 3
2019
Pharmacokinetics, Safety, and Tolerability of Multiple Doses of the Novel Oxytocin Receptor Antagonist Cligosiban in Development for Premature Ejaculation: Two Randomized Clinical Trials in Healthy Subjects.
The journal of sexual medicine, Volume: 16, Issue: 2
2019
Predicting the Effects of Different Triazole Antifungal Agents on the Pharmacokinetics of Tamoxifen.
AAPS PharmSciTech, Jan-02, Volume: 20, Issue: 1
2019
Isavuconazole: Case Report and Pharmacokinetic Considerations.
Chemotherapy, Volume: 63, Issue: 5
2018
Characterization of Stereoselective Metabolism, Inhibitory Effect on Uric Acid Uptake Transporters, and Pharmacokinetics of Lesinurad Atropisomers.
Drug metabolism and disposition: the biological fate of chemicals, Volume: 47, Issue: 2
2019
Inhibitory effect of isavuconazole, ketoconazole, and voriconazole on the pharmacokinetics of methadone in vivo and in vitro.
Drug testing and analysis, Volume: 11, Issue: 4
2019
Pharmacokinetics, Safety, and Tolerability of Single Oral Doses of a Novel Oxytocin Receptor Antagonist-Cligosiban-in Development for Premature Ejaculation: Three Randomized Clinical Trials in Healthy Subjects.
The journal of sexual medicine, Volume: 15, Issue: 11
2018
Clinical Pharmacokinetics of Second-Generation Triazoles for the Treatment of Invasive Aspergillosis and Candidiasis.
European journal of drug metabolism and pharmacokinetics, Volume: 44, Issue: 2
2019
Influence of age and renal impairment on the steady state pharmacokinetics of filgotinib, a selective JAK1 inhibitor.
British journal of clinical pharmacology, Volume: 84, Issue: 12
2018
Clinical Pharmacokinetics and Drug Interactions of Doravirine.
European journal of drug metabolism and pharmacokinetics, Volume: 43, Issue: 6
2018
A pharmacokinetic case study of intravenous posaconazole in a critically ill patient with hypoalbuminaemia receiving continuous venovenous haemodiafiltration.
International journal of antimicrobial agents, Volume: 52, Issue: 4
2018
[Determination of anaprazole in human plasma by LC-MS/MS in pharmacokinetic study].
Yao xue xue bao = Acta pharmaceutica Sinica, Volume: 51, Issue: 12
2016
Pharmacokinetic/Pharmacodynamic Analysis of Isavuconazole Against Aspergillus spp. and Candida spp. in Healthy Subjects and Patients With Hepatic or Renal Impairment by Monte Carlo Simulation.
Journal of clinical pharmacology, Volume: 58, Issue: 10
2018
Clinical Pharmacokinetics and Pharmacodynamics of Isavuconazole.
Clinical pharmacokinetics, Volume: 57, Issue: 12
2018
A Population Pharmacokinetic Model for a Solid Oral Tablet Formulation of Posaconazole.
Antimicrobial agents and chemotherapy, Volume: 62, Issue: 7
2018
Safety, Tolerability, and Pharmacokinetics of Suvorexant: A Randomized Rising-Dose Trial in Healthy Men.
Clinical drug investigation, Volume: 38, Issue: 7
2018
Clinical Pharmacokinetics and Dose Recommendations for Posaconazole in Infants and Children.
Clinical pharmacokinetics, Volume: 58, Issue: 1
2019
Pharmacokinetics and Tolerability of Letermovir Coadministered With Azole Antifungals (Posaconazole or Voriconazole) in Healthy Subjects.
Journal of clinical pharmacology, Volume: 58, Issue: 7
2018
Isavuconazole: A new broad-spectrum azole. Part 2: pharmacokinetics and clinical activity.
Journal de mycologie medicale, Volume: 28, Issue: 1
2018
Isavuconazole pharmacokinetics in a patient with cystic fibrosis following bilateral orthotopic lung transplantation.
Transplant infectious disease : an official journal of the Transplantation Society, Volume: 20, Issue: 3
2018
Physiologically-based pharmacokinetic modelling of a CYP2C19 substrate, BMS-823778, utilizing pharmacogenetic data.
British journal of clinical pharmacology, Volume: 84, Issue: 6
2018
Effects of posaconazole (a strong CYP3A4 inhibitor), two new tablet formulations, and food on the pharmacokinetics of idasanutlin, an MDM2 antagonist, in patients with advanced solid tumors.
Cancer chemotherapy and pharmacology, Volume: 81, Issue: 3
2018
Discovery of LY3104607: A Potent and Selective G Protein-Coupled Receptor 40 (GPR40) Agonist with Optimized Pharmacokinetic Properties to Support Once Daily Oral Treatment in Patients with Type 2 Diabetes Mellitus.
Journal of medicinal chemistry, 02-08, Volume: 61, Issue: 3
2018
Comparison of pharmacokinetics of newly discovered aromatase inhibitors by a cassette microdosing approach in healthy Japanese subjects.
Drug metabolism and pharmacokinetics, Volume: 32, Issue: 6
2017
A Review of the Clinical Pharmacokinetics and Pharmacodynamics of Isavuconazole.
European journal of drug metabolism and pharmacokinetics, Volume: 43, Issue: 3
2018
Effect of pharmacogenetic markers of vitamin D pathway on deferasirox pharmacokinetics in children.
Pharmacogenetics and genomics, Volume: 28, Issue: 1
2018
Development of an Adult Physiologically Based Pharmacokinetic Model of Solithromycin in Plasma and Epithelial Lining Fluid.
CPT: pharmacometrics & systems pharmacology, Volume: 6, Issue: 12
2017
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Onset of Action (2)

ArticleYear
Novel short-acting A2A adenosine receptor agonists for coronary vasodilation: inverse relationship between affinity and duration of action of A2A agonists.
The Journal of pharmacology and experimental therapeutics, Volume: 298, Issue: 1
2001
Comparison of antisecretory potency and duration of action of the H2-receptor antagonists AH 22216, cimetidine, ranitidine and SK & F 93479 in the dog.
Agents and actions, Volume: 13, Issue: 2-3
1983
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioavailability (375)

ArticleYear
Triazole hybrid compounds: A new frontier in malaria treatment.
European journal of medicinal chemistry, Nov-05, Volume: 259
2023
Population Pharmacokinetics of Posaconazole in Immune-Compromised Children and Assessment of Target Attainment in Invasive Fungal Disease.
Clinical pharmacokinetics, Volume: 62, Issue: 7
2023
Permeability of New Antifungal Fluconazole Derivatives through a Lipophilic Membrane: Experiment and Modeling.
Molecules (Basel, Switzerland), Jan-02, Volume: 28, Issue: 1
2023
An Integrated Population Pharmacokinetic Analysis for Posaconazole Oral Suspension, Delayed-Release Tablet, and Intravenous Infusion in Healthy Volunteers.
Drugs, Volume: 83, Issue: 1
2023
Clinical research advances of isavuconazole in the treatment of invasive fungal diseases.
Frontiers in cellular and infection microbiology, Volume: 12
2022
Structure-Based Design of Tropane Derivatives as a Novel Series of CCR5 Antagonists with Broad-Spectrum Anti-HIV-1 Activities and Improved Oral Bioavailability.
Journal of medicinal chemistry, 12-22, Volume: 65, Issue: 24
2022
In silico identification of 1,2,4-triazoles as potential Candida Albicans inhibitors using 3D-QSAR, molecular docking, molecular dynamics simulations, and ADMET profiling.
Molecular diversity, Volume: 27, Issue: 5
2023
Semisynthetic Derivatives of Pentacyclic Triterpenes Bearing Heterocyclic Moieties with Therapeutic Potential.
Molecules (Basel, Switzerland), Oct-03, Volume: 27, Issue: 19
2022
Radiotherapy-induced oxidative stress and fibrosis in breast cancer are suppressed by vactosertib, a novel, orally bioavailable TGF-β/ALK5 inhibitor.
Scientific reports, 09-27, Volume: 12, Issue: 1
2022
Discovery and Optimization of the First Highly Effective and Orally Available Galectin-3 Inhibitors for Treatment of Fibrotic Disease.
Journal of medicinal chemistry, 10-13, Volume: 65, Issue: 19
2022
Population pharmacokinetics of posaconazole in Chinese pediatric patients with acute leukaemia: Effect of food on bioavailability and dose optimization.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, Nov-01, Volume: 178
2022
Single oral or intravenous administration of voriconazole achieved recommended therapeutic minimum inhibitory concentrations against Aspergillus in the common raven (Corvus corax).
American journal of veterinary research, Aug-31, Volume: 83, Issue: 10
2022
Incorporating Tenax into the in vitro method to improve the predictive capability of bioaccessibility of triazole fungicides in grape.
Food chemistry, Dec-01, Volume: 396
2022
Biopredictive capability assessment of two dissolution/permeation assays, µFLUX™ and PermeaLoop™, using supersaturating formulations of Posaconazole.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, Sep-01, Volume: 176
2022
Pharmacokinetics of isavuconazole in healthy cats after oral and intravenous administration.
Journal of veterinary internal medicine, Volume: 36, Issue: 4
2022
Contributions of intestine and liver to the absorption and disposition of FZJ-003, a selective JAK1 inhibitor with structure modification of filgotinib.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, Aug-01, Volume: 175
2022
Co-treatment with vactosertib, a novel, orally bioavailable activin receptor-like kinase 5 inhibitor, suppresses radiotherapy-induced epithelial-to-mesenchymal transition, cancer cell stemness, and lung metastasis of breast cancer.
Radiology and oncology, 04-07, Volume: 56, Issue: 2
2022
Posaconazole bioavailability of the solid oral tablet is reduced during severe intestinal mucositis.
Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases, Volume: 28, Issue: 7
2022
Proof of Concept in Assignment of Within-Subject Variability During Virtual Bioequivalence Studies: Propagation of Intra-Subject Variation in Gastrointestinal Physiology Using Physiologically Based Pharmacokinetic Modeling.
The AAPS journal, 01-05, Volume: 24, Issue: 1
2022
Persistence Pays Off: Milvexian Emerges from the Industry's Longstanding Search for Orally Bioavailable Factor XIa Inhibitors.
Journal of medicinal chemistry, 02-10, Volume: 65, Issue: 3
2022
Accumulation of epoxiconazole from soil via oleic acid-embedded cellulose acetate membranes and bioavailability evaluation in earthworms (Eisenia fetida).
Environmental pollution (Barking, Essex : 1987), Jan-01, Volume: 292, Issue: Pt A
2022
Discovery of Milvexian, a High-Affinity, Orally Bioavailable Inhibitor of Factor XIa in Clinical Studies for Antithrombotic Therapy.
Journal of medicinal chemistry, 02-10, Volume: 65, Issue: 3
2022
Suboptimal plasma concentrations with posaconazole suspension as prophylaxis in critically ill COVID-19 patients at risk of Covid-associated pulmonary aspergillosis.
Journal of clinical pharmacy and therapeutics, Volume: 47, Issue: 3
2022
Cu(I)-Catalyzed Click Chemistry in Glycoscience and Their Diverse Applications.
Chemical reviews, 07-14, Volume: 121, Issue: 13
2021
1,2,3-Triazoles as Biomimetics in Peptide Science.
Molecules (Basel, Switzerland), May-14, Volume: 26, Issue: 10
2021
A highly sensitive and selective UPLC-MS/MS assay for the determination of enarodustat (JTZ-951) in human plasma.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, Jun-30, Volume: 1176
2021
Disposition of posaconazole after single oral administration in large falcons (Falco spp): Effect of meal and dosage and a non-compartmental model to predict effective dosage.
Medical mycology, Sep-03, Volume: 59, Issue: 9
2021
JTZ-951 (enarodustat), a hypoxia-inducible factor prolyl hydroxylase inhibitor, improves iron utilization and anemia of inflammation: Comparative study against recombinant erythropoietin in rat.
European journal of pharmacology, May-05, Volume: 898
2021
Triazole fungicides in soil affect the yield of fruit, green biomass, and phenolics production of Solanum lycopersicum L.
Food chemistry, Jul-30, Volume: 351
2021
A Population Pharmacokinetic Modeling and Simulation Study of Posaconazole Oral Suspension in Immunocompromised Pediatric Patients: A Short Communication.
Therapeutic drug monitoring, 08-01, Volume: 43, Issue: 4
2021
Conazole fungicides epoxiconazole and tebuconazole in biochar amended soils: Degradation and bioaccumulation in earthworms.
Chemosphere, Volume: 274
2021
Selinexor, a First in Class, Nuclear Export Inhibitor for the Treatment of Advanced Malignant Peripheral Nerve Sheath Tumor.
The oncologist, Volume: 26, Issue: 4
2021
Residual analysis of chitosan-based agronanofungicides as a sustainable alternative in oil palm disease management.
Scientific reports, 12-18, Volume: 10, Issue: 1
2020
A copper(II)-binding triazole derivative with ionophore properties is active against Candida spp.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry, Volume: 25, Issue: 8
2020
Novel High-Drug-Loaded Amorphous Dispersion Tablets of Posaconazole;
Molecular pharmaceutics, 12-07, Volume: 17, Issue: 12
2020
Ageing effect on conazole fungicide bioaccumulation in arable soils.
Chemosphere, Volume: 262
2021
PBPK modeling of CYP3A and P-gp substrates to predict drug-drug interactions in patients undergoing Roux-en-Y gastric bypass surgery.
Journal of pharmacokinetics and pharmacodynamics, Volume: 47, Issue: 5
2020
Comparative assessment of in vitro/in vivo performances of orodispersible electrospun and casting films containing rizatriptan benzoate.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, Volume: 154
2020
Pentabromobenzyl-RP versus triazole-HILIC columns for separation of the polar basic analytes famotidine and famotidone: LC method development combined with in silico tools to follow the potential consequences of famotidine gastric instability.
Journal of pharmaceutical and biomedical analysis, Jul-15, Volume: 186
2020
Absorption, distribution, metabolism and excretion of molidustat in healthy participants.
Basic & clinical pharmacology & toxicology, Volume: 127, Issue: 3
2020
Composition and Orientation of the Core Region of Novel HIV-1 Entry Inhibitors Influences Metabolic Stability.
Molecules (Basel, Switzerland), Mar-21, Volume: 25, Issue: 6
2020
Synthesis of biocompatible triazole based non-ionic surfactant and its vesicular drug delivery investigation.
Chemistry and physics of lipids, Volume: 228
2020
Comparative Bioavailability of Oral Granule Formulations of the HIV Antiretroviral Drugs Doravirine, Lamivudine, and Tenofovir Disoproxil Fumarate.
AAPS PharmSciTech, Feb-13, Volume: 21, Issue: 3
2020
Integrated nanovesicular/self-nanoemulsifying system (INV/SNES) for enhanced dual ocular drug delivery: statistical optimization, in vitro and in vivo evaluation.
Drug delivery and translational research, Volume: 10, Issue: 3
2020
The influence of crushing amorphous solid dispersion dosage forms on the in-vitro dissolution kinetics.
International journal of pharmaceutics, Jan-05, Volume: 573
2020
Evaluation of posaconazole plasma concentrations achieved with the delayed-release tablets in Korean high-risk patients with haematologic malignancy.
Mycoses, Volume: 63, Issue: 2
2020
Interplay of Supersaturation and Solubilization: Lack of Correlation between Concentration-Based Supersaturation Measurements and Membrane Transport Rates in Simulated and Aspirated Human Fluids.
Molecular pharmaceutics, 12-02, Volume: 16, Issue: 12
2019
High Proliferation Rate and a Compromised Spindle Assembly Checkpoint Confers Sensitivity to the MPS1 Inhibitor BOS172722 in Triple-Negative Breast Cancers.
Molecular cancer therapeutics, Volume: 18, Issue: 10
2019
Adsorption behavior of three triazole fungicides on polystyrene microplastics.
The Science of the total environment, Nov-15, Volume: 691
2019
Microbiological and biochemical properties of soil polluted with a mixture of spiroxamine, tebuconazole, and triadimenol under the cultivation of Triticum aestivum L.
Environmental monitoring and assessment, Jun-06, Volume: 191, Issue: 7
2019
XPO1 inhibitor KPT-330 synergizes with Bcl-xL inhibitor to induce cancer cell apoptosis by perturbing rRNA processing and Mcl-1 protein synthesis.
Cell death & disease, 05-21, Volume: 10, Issue: 6
2019
Fate and bioavailability of four conazole fungicides in twelve different arable soils - Effects of soil and pesticide properties.
Chemosphere, Volume: 230
2019
Improved predictions of time-dependent drug-drug interactions by determination of cytosolic drug concentrations.
Scientific reports, 04-10, Volume: 9, Issue: 1
2019
Molecular hybridization approach for phenothiazine incorporated 1,2,3-triazole hybrids as promising antimicrobial agents: Design, synthesis, molecular docking and in silico ADME studies.
European journal of medicinal chemistry, Apr-15, Volume: 168
2019
The Relative Bioavailability and Effects of Food and Acid-Reducing Agents on Filgotinib Tablets in Healthy Subjects.
Clinical pharmacology in drug development, Volume: 8, Issue: 5
2019
Therapeutic drug monitoring and adverse events of delayed-release posaconazole tablets in patients with chronic pulmonary aspergillosis.
The Journal of antimicrobial chemotherapy, 04-01, Volume: 74, Issue: 4
2019
A brain-penetrant triazolopyrimidine enhances microtubule-stability, reduces axonal dysfunction and decreases tau pathology in a mouse tauopathy model.
Molecular neurodegeneration, 11-07, Volume: 13, Issue: 1
2018
Clinical Pharmacokinetics of Second-Generation Triazoles for the Treatment of Invasive Aspergillosis and Candidiasis.
European journal of drug metabolism and pharmacokinetics, Volume: 44, Issue: 2
2019
5-Benzoyl triazole as new structural dimension in glycoconjugates.
Carbohydrate research, Volume: 469
2018
Metabolism and disposition of lesinurad, a uric acid reabsorption inhibitor, in humans.
Xenobiotica; the fate of foreign compounds in biological systems, Volume: 49, Issue: 7
2019
Impact of patient education on plasma concentrations and effectiveness of posaconazole oral suspension under clinical conditions.
Basic & clinical pharmacology & toxicology, Volume: 124, Issue: 1
2019
In vitro antileishmanial activity of ravuconazole, a triazole antifungal drug, as a potential treatment for leishmaniasis.
The Journal of antimicrobial chemotherapy, 09-01, Volume: 73, Issue: 9
2018
A Population Pharmacokinetic Model for a Solid Oral Tablet Formulation of Posaconazole.
Antimicrobial agents and chemotherapy, Volume: 62, Issue: 7
2018
Enhanced delivery of fixed-dose combination of synergistic antichagasic agents posaconazole-benznidazole based on amorphous solid dispersions.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, Jul-01, Volume: 119
2018
Clinical Pharmacokinetics and Dose Recommendations for Posaconazole in Infants and Children.
Clinical pharmacokinetics, Volume: 58, Issue: 1
2019
Clinical Implications of Targeting XPO1-mediated Nuclear Export in Multiple Myeloma.
Clinical lymphoma, myeloma & leukemia, Volume: 18, Issue: 5
2018
Isavuconazole: A new broad-spectrum azole. Part 2: pharmacokinetics and clinical activity.
Journal de mycologie medicale, Volume: 28, Issue: 1
2018
Discovery of Molidustat (BAY 85-3934): A Small-Molecule Oral HIF-Prolyl Hydroxylase (HIF-PH) Inhibitor for the Treatment of Renal Anemia.
ChemMedChem, 05-23, Volume: 13, Issue: 10
2018
ANTIBACTERIAL AND CENTRAL NERVOUS SYSTEM ACTIVITY OF (4,5-DIARYL-4H-1,2,4-TRIAZOL-3-YL)METHACRYLIC ACID DERIVATIVES.
Acta poloniae pharmaceutica, Volume: 74, Issue: 1
2017
Development of MK-8353, an orally administered ERK1/2 inhibitor, in patients with advanced solid tumors.
JCI insight, 02-22, Volume: 3, Issue: 4
2018
Evaluation and optimized selection of supersaturating drug delivery systems of posaconazole (BCS class 2b) in the gastrointestinal simulator (GIS): An in vitro-in silico-in vivo approach.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, Mar-30, Volume: 115
2018
Prevention of Invasive Aspergillus Fungal Infections with the Suspension and Delayed-Release Tablet Formulations of Posaconazole in Patients with Haematologic Malignancies.
Scientific reports, 01-26, Volume: 8, Issue: 1
2018
Effects of posaconazole (a strong CYP3A4 inhibitor), two new tablet formulations, and food on the pharmacokinetics of idasanutlin, an MDM2 antagonist, in patients with advanced solid tumors.
Cancer chemotherapy and pharmacology, Volume: 81, Issue: 3
2018
Discovery of LY3104607: A Potent and Selective G Protein-Coupled Receptor 40 (GPR40) Agonist with Optimized Pharmacokinetic Properties to Support Once Daily Oral Treatment in Patients with Type 2 Diabetes Mellitus.
Journal of medicinal chemistry, 02-08, Volume: 61, Issue: 3
2018
Bioavailability of Metsulfuron and Sulfentrazone Herbicides in Soil as Affected by Amendment with Two Contrasting Willow Biochars.
Bulletin of environmental contamination and toxicology, Volume: 100, Issue: 2
2018
Comparison of pharmacokinetics of newly discovered aromatase inhibitors by a cassette microdosing approach in healthy Japanese subjects.
Drug metabolism and pharmacokinetics, Volume: 32, Issue: 6
2017
A Review of the Clinical Pharmacokinetics and Pharmacodynamics of Isavuconazole.
European journal of drug metabolism and pharmacokinetics, Volume: 43, Issue: 3
2018
Structure-based development of novel triazoles and related thiazolotriazoles as anticancer agents and Cdc25A/B phosphatase inhibitors. Synthesis, in vitro biological evaluation, molecular docking and in silico ADME-T studies.
European journal of medicinal chemistry, Oct-20, Volume: 139
2017
Expanding the Therapeutic Potential of the Iron Chelator Deferasirox in the Development of Aqueous Stable Ti(IV) Anticancer Complexes.
Inorganic chemistry, Jul-17, Volume: 56, Issue: 14
2017
Cost-effectiveness of posaconazole tablets versus fluconazole as prophylaxis for invasive fungal diseases in patients with graft-versus-host disease after allogeneic hematopoietic stem cell transplantation.
The European journal of health economics : HEPAC : health economics in prevention and care, Volume: 19, Issue: 4
2018
Enhancement of dissolution rate through eutectic mixture and solid solution of posaconazole and benznidazole.
International journal of pharmaceutics, Jun-15, Volume: 525, Issue: 1
2017
Therapeutic drug monitoring for invasive mould infections and disease: pharmacokinetic and pharmacodynamic considerations.
The Journal of antimicrobial chemotherapy, 03-01, Volume: 72, Issue: suppl_1
2017
The Effect of Food on Doravirine Bioavailability: Results from Two Pharmacokinetic Studies in Healthy Subjects.
Clinical drug investigation, Volume: 37, Issue: 6
2017
Impact of Mucositis on Absorption and Systemic Drug Exposure of Isavuconazole.
Antimicrobial agents and chemotherapy, Volume: 61, Issue: 6
2017
Cognition in female rats after blocking conversion of androgens to estrogens.
Hormones and behavior, Volume: 90
2017
Effect of gender and age on the relative bioavailability of doravirine: results of a Phase I trial in healthy subjects.
Antiviral therapy, Volume: 22, Issue: 4
2017
[A Case of Interstitial Pneumonitis Induced by Lapatinib plus Letrozole].
Gan to kagaku ryoho. Cancer & chemotherapy, Volume: 43, Issue: 12
2016
Discovery of First-in-Class, Potent, and Orally Bioavailable Embryonic Ectoderm Development (EED) Inhibitor with Robust Anticancer Efficacy.
Journal of medicinal chemistry, 03-23, Volume: 60, Issue: 6
2017
Novel amphiphilic chitosan nanocarriers for sustained oral delivery of hydrophobic drugs.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, Mar-01, Volume: 99
2017
Preparation and evaluation of posaconazole-loaded enteric microparticles in rats.
Drug development and industrial pharmacy, Volume: 43, Issue: 4
2017
Prediction of Plasma Concentration-time Profiles of Drugs in Humans from Animals Following Oral Administration: An Allometric Approach.
Current drug metabolism, Volume: 17, Issue: 10
2016
Toxicity, pharmacokinetics and metabolism of a novel inhibitor of IL-6-induced STAT3 activation.
Cancer chemotherapy and pharmacology, Volume: 78, Issue: 6
2016
Inhibition of EGFR, HER2, and HER3 signaling with AZD8931 in combination with anastrozole as an anticancer approach: Phase II randomized study in women with endocrine-therapy-naïve advanced breast cancer.
Breast cancer research and treatment, Volume: 160, Issue: 1
2016
Discovery of 8-Trifluoromethyl-3-cyclopropylmethyl-7-[(4-(2,4-difluorophenyl)-1-piperazinyl)methyl]-1,2,4-triazolo[4,3-a]pyridine (JNJ-46356479), a Selective and Orally Bioavailable mGlu2 Receptor Positive Allosteric Modulator (PAM).
Journal of medicinal chemistry, 09-22, Volume: 59, Issue: 18
2016
Increased inhibition of cytochrome P450 3A4 with the tablet formulation of posaconazole.
Drug metabolism and pharmacokinetics, Volume: 31, Issue: 5
2016
Synthesis and biological evaluation of some novel triazole hybrids of curcumin mimics and their selective anticancer activity against breast and prostate cancer cell lines.
Bioorganic & medicinal chemistry letters, 09-01, Volume: 26, Issue: 17
2016
Isavuconazole absorption following oral administration in healthy subjects is comparable to intravenous dosing, and is not affected by food, or drugs that alter stomach pH.
International journal of clinical pharmacology and therapeutics, Volume: 54, Issue: 8
2016
Sodium Lauryl Sulfate Competitively Interacts with HPMC-AS and Consequently Reduces Oral Bioavailability of Posaconazole/HPMC-AS Amorphous Solid Dispersion.
Molecular pharmaceutics, 08-01, Volume: 13, Issue: 8
2016
Synthesis, Anticlotting and Antiplatelet Effects of 1,2,3-Triazoles Derivatives.
Medicinal chemistry (Shariqah (United Arab Emirates)), Volume: 12, Issue: 8
2016
Characterization of Brain-Penetrant Pyrimidine-Containing Molecules with Differential Microtubule-Stabilizing Activities Developed as Potential Therapeutic Agents for Alzheimer's Disease and Related Tauopathies.
The Journal of pharmacology and experimental therapeutics, Volume: 357, Issue: 2
2016
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Dosage (1115)

ArticleYear
Triazole Antifungal Quantification for Therapeutic Drug Monitoring in Serum by Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS): Posaconazole, Voriconazole, Itraconazole, and Hydroxyitraconazole.
Methods in molecular biology (Clifton, N.J.), Volume: 2737
2024
Population Pharmacokinetics of Total and Unbound Isavuconazole in Critically Ill Patients: Implications for Adaptive Dosing Strategies.
Clinical pharmacokinetics, Volume: 62, Issue: 12
2023
Effect of Processing on Reduction in Chiral Pesticide Hexaconazole for Kiwifruit Juice.
Molecules (Basel, Switzerland), Aug-17, Volume: 28, Issue: 16
2023
Combination chelation therapy.
Annals of the New York Academy of Sciences, Volume: 1529, Issue: 1
2023
Ferrozoles: Ferrocenyl derivatives of letrozole with dual effects as potent aromatase inhibitors and cytostatic agents.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry, Volume: 28, Issue: 6
2023
Population Pharmacokinetics of Posaconazole in Immune-Compromised Children and Assessment of Target Attainment in Invasive Fungal Disease.
Clinical pharmacokinetics, Volume: 62, Issue: 7
2023
Population Pharmacokinetics, Exposure-Safety, and Probability of Target Attainment Analyses for Isavuconazole in Japanese Patients With Deep-Seated Mycoses.
Journal of clinical pharmacology, Volume: 63, Issue: 6
2023
An Integrated Population Pharmacokinetic Analysis for Posaconazole Oral Suspension, Delayed-Release Tablet, and Intravenous Infusion in Healthy Volunteers.
Drugs, Volume: 83, Issue: 1
2023
1,2,3-Triazole Derivatives as Novel Antifibrinolytic Drugs.
International journal of molecular sciences, Nov-29, Volume: 23, Issue: 23
2022
Progress of triazole antifungal agent posaconazole in individualized therapy.
Journal of clinical pharmacy and therapeutics, Volume: 47, Issue: 12
2022
Model-Informed Dose Justifications of Posaconazole in Japanese Patients for Prophylaxis and Treatment Against Fungal Infection.
Journal of clinical pharmacology, Volume: 63, Issue: 4
2023
A Review of Population Pharmacokinetic Models of Posaconazole.
Drug design, development and therapy, Volume: 16
2022
Different spectrophotometric methods for simultaneous determination of lesinurad and allopurinol in the new FDA approved pharmaceutical preparation; additional greenness evaluation.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, Jan-15, Volume: 285
2023
Effect of posaconazole on the concentration of intravenous and oral cyclosporine in patients undergoing hematopoietic stem cell transplantation.
European journal of clinical pharmacology, Volume: 78, Issue: 10
2022
Population pharmacokinetics of posaconazole in Chinese pediatric patients with acute leukaemia: Effect of food on bioavailability and dose optimization.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, Nov-01, Volume: 178
2022
Dose of deferasirox correlates with its effects, which differ between low-risk myelodysplastic syndrome and aplastic anaemia.
Journal of clinical pharmacy and therapeutics, Volume: 47, Issue: 10
2022
Inhibition of Mtorc1/2 and DNA-PK via CC-115 Synergizes with Carboplatin and Paclitaxel in Lung Squamous Cell Carcinoma.
Molecular cancer therapeutics, 09-06, Volume: 21, Issue: 9
2022
Contributions of intestine and liver to the absorption and disposition of FZJ-003, a selective JAK1 inhibitor with structure modification of filgotinib.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, Aug-01, Volume: 175
2022
Efficacy and Tolerability of Twice-Daily Dosing Schedule of Deferasirox in Transfusion-Dependent Paediatric Beta-Thalassaemia Patients: A Randomized Controlled Study.
Journal of pharmacy practice, Volume: 36, Issue: 4
2023
Exposure to intravenous posaconazole in critically ill patients with influenza: A pharmacokinetic analysis of the POSA-FLU study.
Mycoses, Volume: 65, Issue: 6
2022
Removal of doravirine by haemodialysis in people living with HIV with end-stage renal disease.
The Journal of antimicrobial chemotherapy, 06-29, Volume: 77, Issue: 7
2022
Ganetespib selectively sensitizes cancer cells for proximal and distal spread-out Bragg peak proton irradiation.
Radiation oncology (London, England), Apr-11, Volume: 17, Issue: 1
2022
Decreased isavuconazole trough concentrations in the treatment of invasive aspergillosis in an adult patient receiving extracorporeal membrane oxygenation support.
American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists, 07-22, Volume: 79, Issue: 15
2022
Guidance for Use and dosing of Selinexor in Multiple Myeloma in 2021: Consensus From International Myeloma Foundation Expert Roundtable.
Clinical lymphoma, myeloma & leukemia, Volume: 22, Issue: 7
2022
Longitudinal multimodal imaging-compatible mouse model of triazole-sensitive and -resistant invasive pulmonary aspergillosis.
Disease models & mechanisms, 03-01, Volume: 15, Issue: 3
2022
Real-World Comparison of Isavuconazole and Voriconazole in Terms of the Need for Dosage Adjustments Guided by Clinical Pharmacological Advice During Primary Prophylaxis of Invasive Fungal Infections in Pediatric Patients with Hemato-Oncological Malignanci
Therapeutic drug monitoring, 10-01, Volume: 44, Issue: 5
2022
A novel validated simple derivatization liquid chromatographic method with diode array detection for the simultaneous determination of mancozeb, azoxystrobin and difenoconazole in pesticide dosage form.
Analytical methods : advancing methods and applications, 03-03, Volume: 14, Issue: 9
2022
The DNA-PK Inhibitor AZD7648 Sensitizes Patient-Derived Ovarian Cancer Xenografts to Pegylated Liposomal Doxorubicin and Olaparib Preventing Abdominal Metastases.
Molecular cancer therapeutics, 04-01, Volume: 21, Issue: 4
2022
Use of Modeling and Simulation to Predict the Influence of Triazole Antifungal Agents on the Pharmacokinetics of Crizotinib.
Clinical pharmacology in drug development, Volume: 11, Issue: 6
2022
Development of a Once-Daily Modified-Release Formulation for the Short Half-Life RIPK1 Inhibitor GSK2982772 using DiffCORE Technology.
Pharmaceutical research, Volume: 39, Issue: 1
2022
The impact of filgotinib on patient-reported outcomes and health-related quality of life for patients with active rheumatoid arthritis: a post hoc analysis of Phase 3 studies.
Arthritis research & therapy, 01-03, Volume: 24, Issue: 1
2022
Therapeutic drug monitoring of posaconazole delayed release tablet while managing COVID-19-associated mucormycosis in a real-life setting.
Mycoses, Volume: 65, Issue: 3
2022
Integrating in vitro chemical transplacental passage into a generic PBK model: A QIVIVE approach.
Toxicology, 01-15, Volume: 465
2022
Milvexian for the Prevention of Venous Thromboembolism.
The New England journal of medicine, 12-02, Volume: 385, Issue: 23
2021
Population pharmacokinetics of a posaconazole tablet formulation in transplant adult allogeneic stem cell recipients.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, Jan-01, Volume: 168
2022
Evaluation of Voriconazole and Posaconazole Dosing in Patients With Thermal Burn Injuries.
Journal of burn care & research : official publication of the American Burn Association, 07-01, Volume: 43, Issue: 4
2022
Posaconazole treatment of refractory coccidioidomycosis in dogs.
Journal of veterinary internal medicine, Volume: 35, Issue: 6
2021
First-in-human study of milvexian, an oral, direct, small molecule factor XIa inhibitor.
Clinical and translational science, Volume: 15, Issue: 2
2022
The 'comeback' of Selinexor: From toxic to tolerable.
Current problems in cancer, Volume: 46, Issue: 1
2022
Pharmacological management of antifungal agents in pulmonary aspergillosis: an updated review.
Expert review of anti-infective therapy, Volume: 20, Issue: 2
2022
Comparative effects of fluconazole, posaconazole, and isavuconazole upon tacrolimus and cyclosporine serum concentrations.
Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners, Volume: 28, Issue: 6
2022
Human metabolism and kinetics of the UV absorber 2-(2H-benzotriazol-2-yl)-4,6-di-tert-pentylphenol (UV 328) after oral administration.
Archives of toxicology, Volume: 95, Issue: 8
2021
Seeking an optimal dosing regimen for OZ439/DSM265 combination therapy for treating uncomplicated falciparum malaria.
The Journal of antimicrobial chemotherapy, 08-12, Volume: 76, Issue: 9
2021
Thorough QT/QTc Evaluation of the Cardiac Safety of Enarodustat (JTZ-951), an Oral Erythropoiesis-Stimulating Agent, in Healthy Adults.
Clinical pharmacology in drug development, Volume: 10, Issue: 8
2021
Leveraging Physiologically Based Pharmacokinetic Modeling and Experimental Data to Guide Dosing Modification of CYP3A-Mediated Drug-Drug Interactions in the Pediatric Population.
Drug metabolism and disposition: the biological fate of chemicals, Volume: 49, Issue: 9
2021
Development of a Prototype, Once-Daily, Modified-Release Formulation for the Short Half-Life RIPK1 Inhibitor GSK2982772.
Pharmaceutical research, Volume: 38, Issue: 7
2021
FDA Approval Summary: Selinexor for Relapsed or Refractory Diffuse Large B-Cell Lymphoma.
The oncologist, Volume: 26, Issue: 10
2021
Heat Shock Protein 90 Inhibitor Effects on Pancreatic Cancer Cell Cultures.
Pancreas, 04-01, Volume: 50, Issue: 4
2021
Regioselective synthesis of triazolo[3,4-
Folia medica, Apr-30, Volume: 63, Issue: 2
2021
A phase I trial of selinexor plus FLAG-Ida for the treatment of refractory/relapsed adult acute myeloid leukemia patients.
Annals of hematology, Volume: 100, Issue: 6
2021
Selinexor in combination with topotecan in patients with advanced or metastatic solid tumors: Results of an open-label, single-center, multi-arm phase Ib study.
Investigational new drugs, Volume: 39, Issue: 5
2021
Disposition of posaconazole after single oral administration in large falcons (Falco spp): Effect of meal and dosage and a non-compartmental model to predict effective dosage.
Medical mycology, Sep-03, Volume: 59, Issue: 9
2021
Subtherapeutic posaconazole prophylaxis in a gastric bypass patient following hematopoietic stem cell transplantation.
American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists, 07-09, Volume: 78, Issue: 14
2021
Posaconazole micelles for ocular delivery: in vitro permeation, ocular irritation and antifungal activity studies.
Drug delivery and translational research, Volume: 12, Issue: 3
2022
Levels of residues and dietary risk assessment of the fungicides myclobutanil, penconazole, tebuconazole, and triadimenol in squash.
Biomedical chromatography : BMC, Volume: 35, Issue: 8
2021
A simple alternative and improved HPLC method for the estimation of doravirine, lamivudine, and tenofovir disoproxil fumarate in solid oral dosage form.
Biomedical chromatography : BMC, Volume: 35, Issue: 8
2021
In vivo evaluation of combination therapy targeting the isoprenoid biosynthetic pathway.
Pharmacological research, Volume: 167
2021
A Population Pharmacokinetic Modeling and Simulation Study of Posaconazole Oral Suspension in Immunocompromised Pediatric Patients: A Short Communication.
Therapeutic drug monitoring, 08-01, Volume: 43, Issue: 4
2021
Is Posaconazole Really Effective in Adolescent patients as a Prophylactic Agent: Experience of a Tertiary Care Center.
Journal of pediatric hematology/oncology, 07-01, Volume: 43, Issue: 5
2021
Pharmacokinetics and target attainment of intravenous posaconazole in critically ill patients during extracorporeal membrane oxygenation.
The Journal of antimicrobial chemotherapy, 04-13, Volume: 76, Issue: 5
2021
Different chemometric assisted approaches for spectrophotometric quantitative analysis of lesinurad and allopurinol.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, Apr-15, Volume: 251
2021
Dose adjustment of venetoclax when co-administered with posaconazole: clinical drug-drug interaction predictions using a PBPK approach.
Cancer chemotherapy and pharmacology, Volume: 87, Issue: 4
2021
Clinical considerations on posaconazole administration and therapeutic drug monitoring in allogeneic hematopoietic cell transplant recipients.
Medical mycology, Jul-06, Volume: 59, Issue: 7
2021
An update on cefepime and its future role in combination with novel β-lactamase inhibitors for MDR Enterobacterales and Pseudomonas aeruginosa.
The Journal of antimicrobial chemotherapy, 02-11, Volume: 76, Issue: 3
2021
Effects of exposure to prothioconazole and its metabolite prothioconazole-desthio on oxidative stress and metabolic profiles of liver and kidney tissues in male mice.
Environmental pollution (Barking, Essex : 1987), Jan-15, Volume: 269
2021
Determination of Rufinamide in the Presence of 1-[(2,6-Difluorophenyl)Methyl]-1H-1,2,3-Triazole-4 Carboxylic Acid Using RP-HPLC and Derivative Ratio Methods as Stability Indicating Assays to Be Applied on Dosage Form.
Journal of AOAC International, Sep-01, Volume: 103, Issue: 5
2020
Efficacy and Tolerability of Rufinamide in Epileptic Children Younger Than 4 Years.
Journal of child neurology, Volume: 36, Issue: 4
2021
Spectrophotometric determination of lesinurad and allopurinol in recently approved FDA pharmaceutical preparation.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, Feb-15, Volume: 247
2021
Potency and timing of antiviral therapy as determinants of duration of SARS-CoV-2 shedding and intensity of inflammatory response.
Science advances, Volume: 6, Issue: 47
2020
Safety, Pharmacokinetics, and Efficacy of Efinaconazole 10% Topical Solution for Onychomycosis Treatment in Pediatric Patients.
Journal of drugs in dermatology : JDD, Sep-01, Volume: 19, Issue: 9
2020
Midostaurin in acute myeloid leukemia: current evidence and practical considerations in routine clinical use.
Minerva medica, Volume: 111, Issue: 5
2020
Experience using intravenous posaconazole in paediatric and young adult oncology patients.
The Journal of antimicrobial chemotherapy, 12-01, Volume: 75, Issue: 12
2020
Navafenterol (AZD8871) in healthy volunteers: safety, tolerability and pharmacokinetics of multiple ascending doses of this novel inhaled, long-acting, dual-pharmacology bronchodilator, in two phase I, randomised, single-blind, placebo-controlled studies.
Respiratory research, Sep-09, Volume: 21, Issue: Suppl 1
2020
New pharmacologic agents for insomnia and hypersomnia.
Current opinion in pulmonary medicine, Volume: 26, Issue: 6
2020
Application of different spectrofluorimetric methods for determination of lesinurad and allopurinol in pharmaceutical preparation and human plasma.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, Jan-05, Volume: 244
2021
2019 update of the European AIDS Clinical Society Guidelines for treatment of people living with HIV version 10.0.
HIV medicine, Volume: 21, Issue: 10
2020
Novel High-Drug-Loaded Amorphous Dispersion Tablets of Posaconazole;
Molecular pharmaceutics, 12-07, Volume: 17, Issue: 12
2020
Management of posaconazole-induced pseudohyperaldosteronism.
The Journal of antimicrobial chemotherapy, 12-01, Volume: 75, Issue: 12
2020
Evaluating posaconazole dosing regimens of the different formulations against Aspergillus spp. in adults: a pharmacokinetic/pharmacodynamic analysis using Monte Carlo simulation.
International journal of antimicrobial agents, Volume: 56, Issue: 4
2020
Non-invasive monitoring of drug action: A new live in vitro assay design for Chagas' disease drug discovery.
PLoS neglected tropical diseases, Volume: 14, Issue: 7
2020
Initial posaconazole dosing to achieve therapeutic serum posaconazole concentrations among children, adolescents, and young adults receiving delayed-release tablet and intravenous posaconazole.
Pediatric transplantation, Volume: 24, Issue: 6
2020
Comparative assessment of in vitro/in vivo performances of orodispersible electrospun and casting films containing rizatriptan benzoate.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, Volume: 154
2020
Novel methodology to perform incurred sample reanalysis on dried blood spot cards: Experimental data using darolutamide and filgotinib.
Biomedical chromatography : BMC, Volume: 34, Issue: 11
2020
Selinexor (KPT-330), an Oral Selective Inhibitor of Nuclear Export (SINE) Compound, in Combination with FOLFOX in Patients with Metastatic Colorectal Cancer (mCRC) - Final Results of the Phase I Trial SENTINEL.
Current cancer drug targets, Volume: 20, Issue: 10
2020
Optimal oral cyclosporin dosing with concomitant posaconazole post allogeneic stem cell transplantation.
Leukemia & lymphoma, Volume: 61, Issue: 10
2020
A systematic evaluation of zoxamide at enantiomeric level.
The Science of the total environment, Sep-01, Volume: 733
2020
Lessons from isavuconazole therapeutic drug monitoring at a United Kingdom Reference Center.
Medical mycology, Oct-01, Volume: 58, Issue: 7
2020
Daridorexant, a new dual orexin receptor antagonist, in elderly subjects with insomnia disorder.
Neurology, 05-26, Volume: 94, Issue: 21
2020
Rufinamide as add-on therapy in children with epileptic encephalopathies other than Lennox-Gastaut syndrome: A study of 34 patients.
Epilepsy & behavior : E&B, Volume: 108
2020
Phase 2 Study of Seviteronel (INO-464) in Patients With Metastatic Castration-Resistant Prostate Cancer After Enzalutamide Treatment.
Clinical genitourinary cancer, Volume: 18, Issue: 4
2020
Isavuconazole as Primary Antifungal Prophylaxis in Patients With Acute Myeloid Leukemia or Myelodysplastic Syndrome: An Open-label, Prospective, Phase 2 Study.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 05-18, Volume: 72, Issue: 10
2021
The Pharmacokinetic-Pharmacodynamic (PKPD) Relationships of AZD3229, a Novel and Selective Inhibitor of KIT, in a Range of Mouse Xenograft Models of GIST.
Clinical cancer research : an official journal of the American Association for Cancer Research, 07-15, Volume: 26, Issue: 14
2020
Impact of temperature on the toxicity of Kraft 36 EC® (a.s. abamectin) and Score 250 EC® (a.s. difenoconazole) to soil organisms under realistic environmental exposure scenarios.
Ecotoxicology and environmental safety, Volume: 194
2020
Development and validation of a multiplex UHPLC-MS/MS assay with stable isotopic internal standards for the monitoring of the plasma concentrations of the antiretroviral drugs bictegravir, cabotegravir, doravirine, and rilpivirine in people living with HI
Journal of mass spectrometry : JMS, Volume: 55, Issue: 6
2020
Discovery of LY3325656: A GPR142 agonist suitable for clinical testing in human.
Bioorganic & medicinal chemistry letters, 03-01, Volume: 30, Issue: 5
2020
Implications for IV posaconazole dosing in the era of obesity.
The Journal of antimicrobial chemotherapy, 04-01, Volume: 75, Issue: 4
2020
Daridorexant, a New Dual Orexin Receptor Antagonist to Treat Insomnia Disorder.
Annals of neurology, Volume: 87, Issue: 3
2020
Probing in Vitro Release Kinetics of Long-Acting Injectable Nanosuspensions via Flow-NMR Spectroscopy.
Molecular pharmaceutics, 02-03, Volume: 17, Issue: 2
2020
Evaluation of target attainment of oral posaconazole suspension in immunocompromised children.
The Journal of antimicrobial chemotherapy, 03-01, Volume: 75, Issue: 3
2020
Alginate Oligosaccharides Affect Mechanical Properties and Antifungal Activity of Alginate Buccal Films with Posaconazole.
Marine drugs, Dec-09, Volume: 17, Issue: 12
2019
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Interactions (206)

ArticleYear
Isavuconazole-tacrolimus drug-drug interactions in HSCT patients.
The Journal of antimicrobial chemotherapy, 10-03, Volume: 78, Issue: 10
2023
Evaluation of the Drug-Drug Interaction Potential of Ensitrelvir Fumaric Acid with Cytochrome P450 3A Substrates in Healthy Japanese Adults.
Clinical drug investigation, Volume: 43, Issue: 5
2023
Ribosome biogenesis-based predictive biomarkers in endocrine therapy (Anastrozole) combined with mTOR inhibitor (Vistusertib) in endometrial cancer: translational study from the VICTORIA trial in collaboration with the GINECO group.
Molecular oncology, Volume: 17, Issue: 1
2023
Study of the metabolic stability profiles of perampanel, rufinamide and stiripentol and prediction of drug interactions using HepaRG cells as an in vitro human model.
Toxicology in vitro : an international journal published in association with BIBRA, Volume: 82
2022
Network Pharmacology Combined with Metabolomics Approach to Investigate the Toxicity Mechanism of Paclobutrazol.
Chemical research in toxicology, 04-18, Volume: 35, Issue: 4
2022
Therapeutic Drug Monitoring for Rufinamide in Japanese Patients With Epilepsy: Focus on Drug Interactions, Tolerability, and Clinical Effectiveness.
Therapeutic drug monitoring, 08-01, Volume: 44, Issue: 4
2022
Efficacy and safety of filgotinib in combination with methotrexate in Japanese patients with active rheumatoid arthritis who have an inadequate response to methotrexate: Subpopulation analyses of 24-week data of a global phase 3 study (FINCH 1).
Modern rheumatology, Feb-28, Volume: 32, Issue: 2
2022
Management of drug-drug interactions of targeted therapies for haematological malignancies and triazole antifungal drugs.
The Lancet. Haematology, Volume: 9, Issue: 1
2022
Anti-tumor activity of the pan-RAF inhibitor TAK-580 in combination with KPT-330 (selinexor) in multiple myeloma.
International journal of hematology, Volume: 115, Issue: 2
2022
The Novel PKC Activator 10-Methyl-Aplog-1 Combined with JQ1 Induced Strong and Synergistic HIV Reactivation with Tolerable Global T Cell Activation.
Viruses, 10-09, Volume: 13, Issue: 10
2021
Selinexor in combination with carboplatin and paclitaxel in patients with advanced solid tumors: Results of a single-center, multi-arm phase Ib study.
Investigational new drugs, Volume: 40, Issue: 2
2022
[Clinical observation on horizontal penetration needling combined with rizatriptan monobenzoate tablets for migraine without aura in acute stage].
Zhongguo zhen jiu = Chinese acupuncture & moxibustion, Sep-12, Volume: 41, Issue: 9
2021
Perioperative anidulafungin combined with triazole prophylaxis for the prevention of early invasive candidiasis in lung transplant recipients.
Transplant infectious disease : an official journal of the Transplantation Society, Volume: 23, Issue: 4
2021
Kinase Inhibitors of DNA-PK, ATM and ATR in Combination with Ionizing Radiation Can Increase Tumor Cell Death in HNSCC Cells While Sparing Normal Tissue Cells.
Genes, 06-17, Volume: 12, Issue: 6
2021
Leveraging Physiologically Based Pharmacokinetic Modeling and Experimental Data to Guide Dosing Modification of CYP3A-Mediated Drug-Drug Interactions in the Pediatric Population.
Drug metabolism and disposition: the biological fate of chemicals, Volume: 49, Issue: 9
2021
Model-based assessments of CYP3A-mediated drug-drug interaction risk of milademetan.
Clinical and translational science, Volume: 14, Issue: 6
2021
Islatravir in combination with doravirine for treatment-naive adults with HIV-1 infection receiving initial treatment with islatravir, doravirine, and lamivudine: a phase 2b, randomised, double-blind, dose-ranging trial.
The lancet. HIV, Volume: 8, Issue: 6
2021
Selinexor in combination with topotecan in patients with advanced or metastatic solid tumors: Results of an open-label, single-center, multi-arm phase Ib study.
Investigational new drugs, Volume: 39, Issue: 5
2021
Establishment and Verification of UPLC-MS/MS Technique for Pharmacokinetic Drug-Drug Interactions of Selinexor with Posaconazole in Rats.
Drug design, development and therapy, Volume: 15
2021
New regimens of benznidazole monotherapy and in combination with fosravuconazole for treatment of Chagas disease (BENDITA): a phase 2, double-blind, randomised trial.
The Lancet. Infectious diseases, Volume: 21, Issue: 8
2021
Selinexor in Combination with R-CHOP for Frontline Treatment of Non-Hodgkin Lymphoma: Results of a Phase I Study.
Clinical cancer research : an official journal of the American Association for Cancer Research, 06-15, Volume: 27, Issue: 12
2021
BET inhibitors combined with chemotherapy synergistically inhibit the growth of NSCLC cells.
Oncology reports, Volume: 45, Issue: 5
2021
HMG-CoA Reductase Inhibitors (Statins) and their Drug Interactions Involving CYP Enzymes, P-glycoprotein and OATP Transporters-An Overview.
Current drug metabolism, Volume: 22, Issue: 5
2021
A phase 1b trial of selinexor, a first-in-class selective inhibitor of nuclear export (SINE), in combination with doxorubicin in patients with advanced soft tissue sarcomas (STS).
European journal of cancer (Oxford, England : 1990), Volume: 144
2021
Dose adjustment of venetoclax when co-administered with posaconazole: clinical drug-drug interaction predictions using a PBPK approach.
Cancer chemotherapy and pharmacology, Volume: 87, Issue: 4
2021
In vitro synergy of isavuconazole in combination with colistin against Candida auris.
Scientific reports, 12-08, Volume: 10, Issue: 1
2020
Phase I study of selinexor in combination with dexamethasone, ifosfamide, carboplatin, etoposide chemotherapy in patients with relapsed or refractory peripheral T-cell or natural-killer/T-cell lymphoma
Haematologica, 12-01, Volume: 106, Issue: 12
2021
Lack of Drug-Drug Interaction Between Filgotinib, a Selective JAK1 Inhibitor, and Oral Hormonal Contraceptives Levonorgestrel/Ethinyl Estradiol in Healthy Volunteers.
Clinical pharmacology in drug development, Volume: 10, Issue: 4
2021
Clinical Pharmacokinetics of the Novel HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitor Doravirine: An Assessment of the Effect of Patient Characteristics and Drug-Drug Interactions.
Clinical drug investigation, Volume: 40, Issue: 10
2020
PBPK modeling of CYP3A and P-gp substrates to predict drug-drug interactions in patients undergoing Roux-en-Y gastric bypass surgery.
Journal of pharmacokinetics and pharmacodynamics, Volume: 47, Issue: 5
2020
Pentabromobenzyl-RP versus triazole-HILIC columns for separation of the polar basic analytes famotidine and famotidone: LC method development combined with in silico tools to follow the potential consequences of famotidine gastric instability.
Journal of pharmaceutical and biomedical analysis, Jul-15, Volume: 186
2020
Inhibition of TGF-β signalling in combination with nal-IRI plus 5-Fluorouracil/Leucovorin suppresses invasion and prolongs survival in pancreatic tumour mouse models.
Scientific reports, 02-19, Volume: 10, Issue: 1
2020
JQ1 inhibits tumour growth in combination with cisplatin and suppresses JAK/STAT signalling pathway in ovarian cancer.
European journal of cancer (Oxford, England : 1990), Volume: 126
2020
Phase I Clinical Trial of Selinexor in Combination with Daunorubicin and Cytarabine in Previously Untreated Poor-Risk Acute Myeloid Leukemia.
Clinical cancer research : an official journal of the American Association for Cancer Research, 01-01, Volume: 26, Issue: 1
2020
Clinical Pharmacodynamics, Pharmacokinetics, and Drug Interaction Profile of Doravirine.
Clinical pharmacokinetics, Volume: 58, Issue: 12
2019
Comparative efficacy and safety of lesinurad 200 mg and 400 mg combined with a xanthine oxidase inhibitor in hyperuricemic patients with gout: A Bayesian network meta-analysis of randomized controlled trials
.
International journal of clinical pharmacology and therapeutics, Volume: 57, Issue: 7
2019
Improved predictions of time-dependent drug-drug interactions by determination of cytosolic drug concentrations.
Scientific reports, 04-10, Volume: 9, Issue: 1
2019
Posaconazole-digoxin drug-drug interaction mediated by inhibition of P-glycoprotein.
Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners, Volume: 25, Issue: 7
2019
Drug-Drug Interaction Between Isavuconazole and Tacrolimus: Is Empiric Dose Adjustment Necessary?
Journal of pharmacy practice, Volume: 33, Issue: 2
2020
Clinical Pharmacokinetics and Drug Interactions of Doravirine.
European journal of drug metabolism and pharmacokinetics, Volume: 43, Issue: 6
2018
Verinurad combined with febuxostat in Japanese adults with gout or asymptomatic hyperuricaemia: a phase 2a, open-label study.
Rheumatology (Oxford, England), 09-01, Volume: 57, Issue: 9
2018
Clinical Drug-Drug Interaction Potential of BFE1224, Prodrug of Antifungal Ravuconazole, Using Two Types of Cocktails in Healthy Subjects.
Clinical and translational science, Volume: 11, Issue: 5
2018
The Effect of Lesinurad in Combination With Allopurinol on Serum Uric Acid Levels in Patients With Gout.
Journal of clinical pharmacology, Volume: 58, Issue: 9
2018
Anti-candidal activity of selected analgesic drugs used alone and in combination with fluconazole, itraconazole, voriconazole, posaconazole and isavuconazole.
Journal de mycologie medicale, Volume: 28, Issue: 2
2018
Pharmacokinetics and Tolerability of Letermovir Coadministered With Azole Antifungals (Posaconazole or Voriconazole) in Healthy Subjects.
Journal of clinical pharmacology, Volume: 58, Issue: 7
2018
Palbociclib in combination with letrozole as first-line treatment for advanced breast cancer: A Japanese phase II study.
Cancer science, Volume: 109, Issue: 3
2018
Predicting effective pro-apoptotic anti-leukaemic drug combinations using co-operative dynamic BH3 profiling.
PloS one, Volume: 13, Issue: 1
2018
Lethal effects of Cr(III) alone and in combination with propiconazole and clothianidin in honey bees.
Chemosphere, Volume: 191
2018
Comparative pharmacokinetics study of anastrozole after single administration and combination with celecoxib.
Xenobiotica; the fate of foreign compounds in biological systems, Volume: 48, Issue: 3
2018
Comparison of micellar extraction combined with ionic liquid based vortex-assisted liquid-liquid microextraction and modified quick, easy, cheap, effective, rugged, and safe method for the determination of difenoconazole in cowpea.
Journal of chromatography. A, Oct-06, Volume: 1518
2017
Evaluation of selected Indian medicinal plants for antagonistic potential against Malassezia spp. and the synergistic effect of embelin in combination with ketoconazole.
Microbial pathogenesis, Volume: 110
2017
Trace determination of five triazole fungicide residues in traditional Chinese medicine samples by dispersive solid-phase extraction combined with ultrasound-assisted dispersive liquid-liquid microextraction and UHPLC-MS/MS.
Journal of separation science, Volume: 40, Issue: 16
2017
Lesinurad, a Selective Uric Acid Reabsorption Inhibitor, in Combination With Febuxostat in Patients With Tophaceous Gout: Findings of a Phase III Clinical Trial.
Arthritis & rheumatology (Hoboken, N.J.), Volume: 69, Issue: 9
2017
Gonadotropin-Releasing Hormone Agonist Combined With a Levonorgestrel-Releasing Intrauterine System or Letrozole for Fertility-Preserving Treatment of Endometrial Carcinoma and Complex Atypical Hyperplasia in Young Women.
International journal of gynecological cancer : official journal of the International Gynecological Cancer Society, Volume: 27, Issue: 6
2017
Comparison of palbociclib in combination with letrozole or fulvestrant with endocrine therapies for advanced/metastatic breast cancer: network meta-analysis.
Current medical research and opinion, Volume: 33, Issue: 8
2017
Evaluation of Active Hexose Correlated Compound (AHCC) in Combination With Anticancer Hormones in Orthotopic Breast Cancer Models.
Integrative cancer therapies, Volume: 16, Issue: 3
2017
Letrozole combined with low dose highly purified HMG for ovulation induction in clomiphene citrate-resistant infertile Chinese women with polycystic ovary syndrome: a prospective study.
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology, Volume: 33, Issue: 6
2017
Synergistic drug combination effectively blocks Ebola virus infection.
Antiviral research, Volume: 137
2017
Quantitative analysis of pharmacokinetic profiles of verapamil and drug-drug interactions induced by a CYP inhibitor using a stable isotope-labeled compound.
Drug metabolism and pharmacokinetics, Volume: 31, Issue: 6
2016
Results of a Doravirine-Atorvastatin Drug-Drug Interaction Study.
Antimicrobial agents and chemotherapy, Volume: 61, Issue: 2
2017
Anti-tumor activity of selective inhibitor of nuclear export (SINE) compounds, is enhanced in non-Hodgkin lymphoma through combination with mTOR inhibitor and dexamethasone.
Cancer letters, 12-28, Volume: 383, Issue: 2
2016
Inhibition of EGFR, HER2, and HER3 signaling with AZD8931 in combination with anastrozole as an anticancer approach: Phase II randomized study in women with endocrine-therapy-naïve advanced breast cancer.
Breast cancer research and treatment, Volume: 160, Issue: 1
2016
Targeting the receptor tyrosine kinase RET in combination with aromatase inhibitors in ER positive breast cancer xenografts.
Oncotarget, Dec-06, Volume: 7, Issue: 49
2016
Lesinurad Combined With Allopurinol: A Randomized, Double-Blind, Placebo-Controlled Study in Gout Patients With an Inadequate Response to Standard-of-Care Allopurinol (a US-Based Study).
Arthritis & rheumatology (Hoboken, N.J.), Volume: 69, Issue: 1
2017
Clinical Drug-Drug Interactions Through Cytochrome P450 3A (CYP3A) for the Selective ALK Inhibitor Alectinib.
Clinical pharmacology in drug development, Volume: 6, Issue: 3
2017
A comparison among different methods of letrozole combined with gonadotropin in an antagonist protocol and high-dose gonadotropin ovarian stimulation antagonist protocol in poor ovarian responders undergoing in vitro fertilization.
Archives of gynecology and obstetrics, Volume: 294, Issue: 5
2016
CCR5 blockade combined with cyclosporine A attenuates liver GVHD by impairing T cells function.
Inflammation research : official journal of the European Histamine Research Society ... [et al.], Volume: 65, Issue: 11
2016
Efficacy and safety of palbociclib in combination with letrozole as first-line treatment of ER-positive, HER2-negative, advanced breast cancer: expanded analyses of subgroups from the randomized pivotal trial PALOMA-1/TRIO-18.
Breast cancer research : BCR, 06-28, Volume: 18, Issue: 1
2016
Pharmacokinetic and Pharmacodynamic Evaluation of the Drug-Drug Interaction Between Isavuconazole and Warfarin in Healthy Subjects.
Clinical pharmacology in drug development, Volume: 6, Issue: 1
2017
Pharmacokinetic Assessment of Drug-Drug Interactions of Isavuconazole With the Immunosuppressants Cyclosporine, Mycophenolic Acid, Prednisolone, Sirolimus, and Tacrolimus in Healthy Adults.
Clinical pharmacology in drug development, Volume: 6, Issue: 1
2017
Drug-Drug Interaction Associated with Mold-Active Triazoles among Hospitalized Patients.
Antimicrobial agents and chemotherapy, Volume: 60, Issue: 6
2016
A Phase I Study of the AKT Inhibitor MK-2206 in Combination with Hormonal Therapy in Postmenopausal Women with Estrogen Receptor-Positive Metastatic Breast Cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research, 06-01, Volume: 22, Issue: 11
2016
Lesinurad in combination with allopurinol: results of a phase 2, randomised, double-blind study in patients with gout with an inadequate response to allopurinol.
Annals of the rheumatic diseases, Volume: 75, Issue: 6
2016
Clinical Confirmation that the Selective JAK1 Inhibitor Filgotinib (GLPG0634) has a Low Liability for Drug-drug Interactions.
Drug metabolism letters, Volume: 10, Issue: 1
2016
Use of letrozole and clomiphene citrate combined with gonadotropins in clomiphene-resistant infertile women with polycystic ovary syndrome: a prospective study.
Drug design, development and therapy, Volume: 9
2015
Arsenic sulfide combined with JQ1, chemotherapy agents, or celecoxib inhibit gastric and colon cancer cell growth.
Drug design, development and therapy, Volume: 9
2015
Phase I/II dose-escalation study of PI3K inhibitors pilaralisib or voxtalisib in combination with letrozole in patients with hormone-receptor-positive and HER2-negative metastatic breast cancer refractory to a non-steroidal aromatase inhibitor.
Breast cancer research and treatment, Volume: 154, Issue: 2
2015
Extended evaluation on the ES-D3 cell differentiation assay combined with the BeWo transport model, to predict relative developmental toxicity of triazole compounds.
Archives of toxicology, Volume: 90, Issue: 5
2016
A randomized phase II study of ganetespib, a heat shock protein 90 inhibitor, in combination with docetaxel in second-line therapy of advanced non-small cell lung cancer (GALAXY-1).
Annals of oncology : official journal of the European Society for Medical Oncology, Volume: 26, Issue: 8
2015
Absence of Drug-Drug Interactions Between Luseogliflozin, a Sodium-Glucose Co-transporter-2 Inhibitor, and Various Oral Antidiabetic Drugs in Healthy Japanese Males.
Advances in therapy, Volume: 32, Issue: 5
2015
The HSP90 inhibitor ganetespib: A potential effective agent for Acute Myeloid Leukemia in combination with cytarabine.
Leukemia research, Volume: 39, Issue: 6
2015
Ex vivo analysis identifies effective HIV-1 latency-reversing drug combinations.
The Journal of clinical investigation, Volume: 125, Issue: 5
2015
TH-302 in Combination with Radiotherapy Enhances the Therapeutic Outcome and Is Associated with Pretreatment [18F]HX4 Hypoxia PET Imaging.
Clinical cancer research : an official journal of the American Association for Cancer Research, Jul-01, Volume: 21, Issue: 13
2015
Minimal stimulation using gonadotropin combined with clomiphene citrate or letrozole for intrauterine insemination.
Yonsei medical journal, Volume: 56, Issue: 2
2015
A computational modelling approach combined with cellular electrophysiology data provides insights into the therapeutic benefit of targeting the late Na+ current.
The Journal of physiology, Mar-15, Volume: 593, Issue: 6
2015
The cyclin-dependent kinase 4/6 inhibitor palbociclib in combination with letrozole versus letrozole alone as first-line treatment of oestrogen receptor-positive, HER2-negative, advanced breast cancer (PALOMA-1/TRIO-18): a randomised phase 2 study.
The Lancet. Oncology, Volume: 16, Issue: 1
2015
Using improved serial blood sampling method of mice to study pharmacokinetics and drug-drug interaction.
Journal of pharmaceutical sciences, Volume: 104, Issue: 3
2015
Effects of modified Shu-Gan-Liang-Xue decoction combined with anastrozole on osteoblastic proliferation and differentiation of MC3T3-E1 cells.
Molecular medicine reports, Volume: 11, Issue: 3
2015
P-glycoprotein inhibition by the agricultural pesticide propiconazole and its hydroxylated metabolites: Implications for pesticide-drug interactions.
Toxicology letters, Jan-05, Volume: 232, Issue: 1
2015
[Effect of genistein combined with anastrozole on mammary tumors in ovariectomized rats].
Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine, Volume: 34, Issue: 4
2014
Fast ultrasound-assisted extraction followed by capillary gas chromatography combined with nitrogen-phosphorous selective detector for the trace determination of tebuconazole in garlic, soil and water samples.
Journal of separation science, Volume: 37, Issue: 11
2014
Safety and efficacy of sitagliptin in combination with transient continuous subcutaneous insulin infusion (CSII) therapy in patients with newly diagnosed type 2 diabetes.
Endocrine journal, Volume: 61, Issue: 5
2014
Clinically relevant drug-drug interactions between antiretrovirals and antifungals.
Expert opinion on drug metabolism & toxicology, Volume: 10, Issue: 4
2014
Norethisterone acetate versus norethisterone acetate combined with letrozole for the treatment of ovarian endometriotic cysts: a patient preference study.
European journal of obstetrics, gynecology, and reproductive biology, Volume: 174
2014
Everolimus in combination with letrozole inhibit human breast cancer MCF-7/Aro stem cells via PI3K/mTOR pathway: an experimental study.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, Volume: 35, Issue: 2
2014
Letrozole combined with gonadotropin-releasing hormone analog for metastatic male breast cancer.
Breast cancer research and treatment, Volume: 141, Issue: 1
2013
The case for aromatase inhibitors use in oncofertility patients. Should aromatase inhibitors be combined with gonadotropin treatment in breast cancer patients undergoing ovarian stimulation for fertility preservation prior to chemotherapy? A debate.
Human fertility (Cambridge, England), Volume: 16, Issue: 4
2013
In vitro activity of miltefosine as a single agent and in combination with voriconazole or posaconazole against uncommon filamentous fungal pathogens.
The Journal of antimicrobial chemotherapy, Volume: 68, Issue: 12
2013
Smac mimetics in combination with TRAIL selectively target cancer stem cells in nasopharyngeal carcinoma.
Molecular cancer therapeutics, Volume: 12, Issue: 9
2013
Synergistic activity of carbosilane dendrimers in combination with maraviroc against HIV in vitro.
AIDS (London, England), Aug-24, Volume: 27, Issue: 13
2013
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Natural Sources (4)

ArticleYear
Direct Keap1-Nrf2 disruption as a potential therapeutic target for Alzheimer's disease.
PLoS genetics, Volume: 13, Issue: 3
2017
The hunt for a selective 17,20 lyase inhibitor; learning lessons from nature.
The Journal of steroid biochemistry and molecular biology, Volume: 163
2016
Synthesis of 3-O-propargylated betulinic acid and its 1,2,3-triazoles as potential apoptotic agents.
European journal of medicinal chemistry, Volume: 63
2013
Essramycin: a first triazolopyrimidine antibiotic isolated from nature.
The Journal of antibiotics, Volume: 61, Issue: 3
2008
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]