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Thymidylate synthase
A thymidylate synthase that is encoded in the genome of mouse. [OMA:P07607, PRO:DNx]
Synonyms
TS;
TSase;
EC 2.1.1.45
Research
Bioassay Publications (29)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 11 (37.93) | 18.7374 |
| 1990's | 13 (44.83) | 18.2507 |
| 2000's | 4 (13.79) | 29.6817 |
| 2010's | 1 (3.45) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Compounds (25)
Drugs with Inhibition Measurements
Drugs with Other Measurements
Synthesis and biological evaluation of unsaturated keto and exomethylene D-arabinopyranonucleoside analogs: novel 5-fluorouracil analogs that target thymidylate synthase.European journal of medicinal chemistry, , Volume: 46, Issue:4, 2011
Synthesis and biological studies of novel nucleoside phosphoramidate prodrugs.Journal of medicinal chemistry, , Dec-06, Volume: 44, Issue:25, 2001
Synthesis and biological activity of aromatic amino acid phosphoramidates of 5-fluoro-2'-deoxyuridine and 1-beta-arabinofuranosylcytosine: evidence of phosphoramidase activity.Journal of medicinal chemistry, , Nov-08, Volume: 39, Issue:23, 1996
5-Substituted N(4)-hydroxy-2'-deoxycytidines and their 5'-monophosphates: synthesis, conformation, interaction with tumor thymidylate synthase, and in vitro antitumor activity.Journal of medicinal chemistry, , Nov-30, Volume: 43, Issue:24, 2000
Synthesis and biological activity of aromatic amino acid phosphoramidates of 5-fluoro-2'-deoxyuridine and 1-beta-arabinofuranosylcytosine: evidence of phosphoramidase activity.Journal of medicinal chemistry, , Nov-08, Volume: 39, Issue:23, 1996
2-Thio derivatives of dUrd and 5-fluoro-dUrd and their 5'-monophosphates: synthesis, interaction with tumor thymidylate synthase, and in vitro antitumor activity.Journal of medicinal chemistry, , Nov-12, Volume: 36, Issue:23, 1993
Comparison of the biological effects of selected 5,8-dideazafolate analogues with their 2-desamino counterparts.Journal of medicinal chemistry, , Volume: 32, Issue:4, 1989
Inhibition of murine thymidylate synthase and human dihydrofolate reductase by 5,8-dideaza analogues of folic acid and aminopterin.Journal of medicinal chemistry, , Volume: 31, Issue:2, 1988
Inhibition by 5-(substituted-benzyl)-2,4-diaminopyrimidines of murine tumor (L5178Y) cell cultures sensitive to and resistant to methotrexate. Further evidence for the sensitivity of resistant cells to hydrophobic drugs.Journal of medicinal chemistry, , Volume: 25, Issue:5, 1982
Design and synthesis of potent non-polyglutamatable quinazoline antifolate thymidylate synthase inhibitors.Journal of medicinal chemistry, , Sep-23, Volume: 42, Issue:19, 1999
Syntheses and thymidylate synthase inhibitory activity of the poly-gamma-glutamyl conjugates of N-[5-[N-(3,4-dihydro-2-methyl-4-oxoquinazolin-6-ylmethyl)-N-methylamino ]-2-thenoyl]-L-glutamic acid (ICI D1694) and other quinazoline antifolates.Journal of medicinal chemistry, , Mar-06, Volume: 35, Issue:5, 1992
Quinazoline antifolate thymidylate synthase inhibitors: bridge modifications and conformationally restricted analogues in the C2-methyl series.Journal of medicinal chemistry, , Volume: 34, Issue:7, 1991
Design and synthesis of potent non-polyglutamatable quinazoline antifolate thymidylate synthase inhibitors.Journal of medicinal chemistry, , Sep-23, Volume: 42, Issue:19, 1999
Quinazoline antifolate thymidylate synthase inhibitors: difluoro-substituted benzene ring analogues.Journal of medicinal chemistry, , Jun-12, Volume: 35, Issue:12, 1992
Syntheses and thymidylate synthase inhibitory activity of the poly-gamma-glutamyl conjugates of N-[5-[N-(3,4-dihydro-2-methyl-4-oxoquinazolin-6-ylmethyl)-N-methylamino ]-2-thenoyl]-L-glutamic acid (ICI D1694) and other quinazoline antifolates.Journal of medicinal chemistry, , Mar-06, Volume: 35, Issue:5, 1992
Quinazoline antifolate thymidylate synthase inhibitors: heterocyclic benzoyl ring modifications.Journal of medicinal chemistry, , Volume: 34, Issue:5, 1991
Quinazoline antifolate thymidylate synthase inhibitors: bridge modifications and conformationally restricted analogues in the C2-methyl series.Journal of medicinal chemistry, , Volume: 34, Issue:7, 1991
Quinazoline antifolate thymidylate synthase inhibitors: benzoyl ring modifications in the C2-methyl series.Journal of medicinal chemistry, , Volume: 33, Issue:11, 1990
Quinazoline antifolate thymidylate synthase inhibitors: alkyl, substituted alkyl, and aryl substituents in the C2 position.Journal of medicinal chemistry, , Volume: 33, Issue:11, 1990
Quinazoline antifolate thymidylate synthase inhibitors: 2'-fluoro-N10-propargyl-5,8-dideazafolic acid and derivatives with modifications in the C2 position.Journal of medicinal chemistry, , Volume: 33, Issue:11, 1990
Cyclopenta[g]quinazoline-based antifolates: the effect of the chirality at the 6-position on the inhibition of thymidylate synthase (TS).Bioorganic & medicinal chemistry letters, , Dec-03, Volume: 11, Issue:23, 2001
Potent inhibition of thymidylate synthase by two series of nonclassical quinazolines.Journal of medicinal chemistry, , Volume: 33, Issue:7, 1990
Comparison of the biological effects of selected 5,8-dideazafolate analogues with their 2-desamino counterparts.Journal of medicinal chemistry, , Volume: 32, Issue:4, 1989
Inhibition of murine thymidylate synthase and human dihydrofolate reductase by 5,8-dideaza analogues of folic acid and aminopterin.Journal of medicinal chemistry, , Volume: 31, Issue:2, 1988
Folate analogues. 30. Synthesis and biological evaluation of N10-propargyl-5,8-dideaza-5,6,7,8-tetrahydrofolic acid and related compounds.Journal of medicinal chemistry, , Volume: 30, Issue:7, 1987
Folate analogues. 25. Synthesis and biological evaluation of N10-propargylfolic acid and its reduced derivatives.Journal of medicinal chemistry, , Volume: 29, Issue:7, 1986
Quinazoline antifolates inhibiting thymidylate synthase: variation of the N10 substituent.Journal of medicinal chemistry, , Volume: 28, Issue:10, 1985
Design and synthesis of potent non-polyglutamatable quinazoline antifolate thymidylate synthase inhibitors.Journal of medicinal chemistry, , Sep-23, Volume: 42, Issue:19, 1999
Quinoline antifolate thymidylate synthase inhibitors: variation of the C2- and C4-substituents.Journal of medicinal chemistry, , Jul-24, Volume: 35, Issue:15, 1992
Quinazoline antifolate thymidylate synthase inhibitors: alkyl, substituted alkyl, and aryl substituents in the C2 position.Journal of medicinal chemistry, , Volume: 33, Issue:11, 1990
Quinazoline antifolate thymidylate synthase inhibitors: 2'-fluoro-N10-propargyl-5,8-dideazafolic acid and derivatives with modifications in the C2 position.Journal of medicinal chemistry, , Volume: 33, Issue:11, 1990
Folate analogues as inhibitors of thymidylate synthase.Journal of medicinal chemistry, , Volume: 30, Issue:4, 1987
Quinazoline antifolate thymidylate synthase inhibitors: bridge modifications and conformationally restricted analogues in the C2-methyl series.Journal of medicinal chemistry, , Volume: 34, Issue:7, 1991
Quinazoline antifolate thymidylate synthase inhibitors: alkyl, substituted alkyl, and aryl substituents in the C2 position.Journal of medicinal chemistry, , Volume: 33, Issue:11, 1990
Quinazoline antifolate thymidylate synthase inhibitors: benzoyl ring modifications in the C2-methyl series.Journal of medicinal chemistry, , Volume: 33, Issue:11, 1990